9results about "Steroids preparation" patented technology

The present invention discloses a method for synthesizing high-purity plant-derived cholesterol, which uses plant-derived 21-hydroxy-20-methylpregn-4-en-3-one, also known as bisnoral alcohol or BA, as raw material, and can synthesize the above cholesterol through steps such as oxidation, Wittig reaction, acetylation, reduction, selective hydrogenation reduction, or can synthesize the above cholesterol through steps such as oxidation, Wittig reaction, acetylation, reduction, hydroxyl protection, selective hydrogenation reduction, deprotection or hydrolysis, and the purity can reach 99% or more. Considering the shortcomings of traditional animal-derived cholesterol, the present invention synthesizes cholesterol from plant-derived raw material BA, which is not only safe and avoids the risk of pathogenic bacteria and virus infection, but also has a high synthesis yield, good product purity, environmentally friendly, and convenient for industrialized production, and the present invention greatly reduces the level of impurities in the product, making it easy to obtain high-purity cholesterol and improving the safety of clinical use.

This invention proposes a method for preparing dehydroepiandrosterone (DHEA), comprising the following steps: S1, dissolving 4-androstenedione in acetic anhydride to obtain a first material, which is then pumped separately into an acetylation microchannel reactor with quaternized GO-phosphotungstic acid catalyst supported on the inner wall for reaction with acetyl chloride; S2, mixing triethyl orthoformate with anhydrous ethanol to obtain a second material, which is then pumped separately into a ketal microchannel reactor with niobium oxide / γ-CD-phosphotungstic acid catalyst supported on the inner wall of the ketal microchannel reactor; S3, dehydrating the effluent from step S2 and adjusting the pH to 7-8, then pumping separately into a reduction microchannel reactor with an ethanol solution containing sodium borohydride for reduction reaction; S4, adding hydrochloric acid to the effluent from step S3 and adjusting the pH to 2-3 to obtain a hydrolysate; evaporating the solvent from the hydrolysate, filtering and drying to obtain DHEA. The supported heteropolyacid composite membrane used in this invention exhibits high catalytic efficiency, high yield, and excellent quality.

The application relates to the technical field and discloses a high-purity separation and extraction method of ginsenoside Re, which comprises the following steps: adopting beta-cyclodextrin pretreatment, ethanol-ionic liquid-water green solvent ultrasonic extraction, specific enrichment through a ginsenoside Re molecular imprinting column, combining high-speed counter-current chromatography refining and freeze drying to obtain a product of high-purity ginsenoside Re. The method solves the problems of low purity, large pollution and long cycle in the prior art, improves the product purity and total recovery rate, reduces the organic solvent consumption, is stable and can be scaled up, and is suitable for the fields of medicines and health products.

The invention relates to a diterpenes type compound, a triterpenes type compound, a preparation method of the diterpenes type compound and the triterpenes type compound, and an application of the diterpenes type compound and the triterpenes type compound. The compounds 1 to 10 provided by the invention are novel diterpene and triterpene compounds which are obtained by extracting and separating from a vine shrub plant tripterygium wilfordii Hook.f. Of a winged euonymus tripterygium genus, and the novel diterpene and triterpene compounds are novel in structure, and the compounds 1 to 10 provided by the invention are novel diterpene and triterpene compounds which are obtained by extracting and separating from the vine shrub plant tripterygium wilfordii Hook.f. Of the winged euonymus tripterygium genus. Bioactivity experiments show that the compound 5 has significant ATP citrate lyase (ACLY) inhibitory activity, and has application potential in research and development of drugs for cancer, hyperlipidemia, atherosclerotic cardiovascular diseases and the like.

This invention provides a targeted osmium complex, its preparation method, and its application. The osmium complex has the structural formula of compound I. Compound I of this invention possesses both high near-infrared light response, good stability, and targeted targeting of endometriosis lesions. It can solve the problems of poor wavelength adaptability and insufficient targeting ability of existing photosensitizers, providing a safe, efficient, and minimally invasive PDT treatment option for endometriosis.

A crystallization device for crude hormone mother liquor includes a crystallization tank. Inside the crystallization tank, a stirring shaft is installed, and several spaced-apart scrapers are mounted on the stirring shaft. A crystallization plate is installed inside the crystallization tank outside the scrapers. A heat exchange tube is installed between the crystallization plate and the crystallization tank. An anti-adhesion layer is provided on the inner wall of the crystallization plate. A vertically arranged polytetrafluoroethylene (PTFE) protective plate is installed outside the scrapers, and the PTFE protective plate is movably in contact with the anti-adhesion layer. This application improves the crystallization and post-crystallization removal efficiency by utilizing the flexibility and non-adhesive properties of the PTFE protective plate and the anti-adhesion layer, thus avoiding adhesion and improving scraping efficiency.

Disclosed in the present invention is a method for extracting and separating cholic acid and deoxycholic acid by a liquid-liquid two-phase system and exhibiting good biocompatibility, low toxicity, and high efficiency. The method comprises: subjecting a feed solution containing an amino acid ionic liquid, and respectively obtaining high-purity cholic acid and deoxycholic acid from an extract liquid and a raffinate. Compared with conventional ionic liquids and organic solvent extractants, the amino acid ionic liquid extractant used in the present invention has the advantages of better degradability, higher biocompatibility, and higher separation efficiency, has the characteristics of large treatment capacity, simple process, low toxicity, environmental friendliness, and low costs, and is suitable for industrial production.

This invention belongs to the field of chemical pharmaceutical technology, specifically relating to a method for preparing norethrin, comprising the following steps: estrone is subjected to etherification, esterification, epoxidation, ring-opening, acetylation, and hydrolysis reactions sequentially to obtain crude norethrin; the crude norethrin is dissolved in acetone and mixed with an acidic catalyst; after the reaction is complete, an alkali is added to quench the reaction, followed by filtration, washing, and drying to obtain a dry sample; the dry sample, isopropyl ether, and methanol are mixed, refluxed to dissolve, cooled to crystallize, filtered, washed, and dried to obtain refined norethrin; the refined norethrin is recrystallized to obtain norethrin; this invention reduces impurity content and improves product purity.