A pharmaceutical composition comprising: (A) at least one compound of formula (I): wherein X is O or S, preferably O R6 is H, C1-6
alkyl, —(CH2)pCOOH, —(CH2)pCOOC1-6
alkyl, —(CH2)pCONH2, —(CH2)pCONHC1-6
alkyl, —(CH2)pCON(C1-6alkyl)2, R11 is H or C1-6 alkyl; each R5 is —OC1-10alkyl, —SC1-10alkyl, —C1-12alkyl, or OAr2; wherein Ar2 is phenyl, optionally substituted with one or more halo; each p is 0 to 3; each z is 1 to 2; or a pharmaceutically acceptable salt, or a
hydrate or solvate thereof; and (B) one or more
corticosteroid partners, preferably selected from the group consisting of
betamethasone,
clobetasol, halometasone,
dexamethasone, fluocortolone, desoximetasone, diflorasone, fluocinonide, flurandrenolide, halobetasol, amcinonide, halocinonide,
triamcinolone,
hydrocortisone, aclometasone,
fluticasone, mometasone, clocortolone, fluocinolone,
desonide,
prednisone,
prednisolone, and prednicarbate or a pharmaceutically acceptable salt, or a
hydrate or solvate thereof, especially
betamethasone or a pharmaceutically acceptable salt, or a
hydrate or solvate thereof.