70results about How to "Reduce or avoid side effects" patented technology

The invention provides a method for preparing an anthracycline antitumor antibiotic oleic acid compound and an oil-water double phase for preparing the compound and albumin, and the anthracycline antitumor antibiotic oleic acid compound is prepared into an albumin nanoparticle preparation. The albumin nanoparticle preparation prepared by the method is little in using amount of auxiliary materials, high in medicine-carrying dose and high in stability, and a preparation process is simple and is suitable for large-scale industrial production; and the albumin nanoparticle preparation has the tumor targeting and good clinical application value.

The invention discloses a method for extracting and synthesizing thymus microcapsule sustained release needle by PLGA which comprises the following steps, (1) carrying out thymolysis in small amount of water, obtaining inner layer water phase, (2) dissolving the PLGA into organic solution, obtaining organic phase, (3) dispersing the inner layer aqueous phase into organic phase during high-speed agitating, obtaining water-in-oil type emulsion (emulsion 1), (4) charging emulsion 1 into outer layer aqueous phase containing dispersing agent, agitating to form double layer emulsion, obtaining water / oil / water composite emulsion, (5) volatilizing the organic solvent and curing the polymeric layer, forming solid microsphere, thus coating the thymus gland at the center of the microsphere.

The invention provides a compatible composition for treating rheumatoid arthritis and a preparation method thereof. The prescription consists of tripterygium wilfordii and peonies, wherein the ratio in part by weight of tripterygium wilfordii to peonies in combination is 0.01-100:1. The effect of the composition for treating rheumatoid arthritis is better than that of tripterygium wilfordii preparations used alone and is better than that of white peony total glycosides used together with tripterygium wilfordii polyglycosides for treating rheumatoid arthritis. Meanwhile, toxic-side effects caused by using the tripterygium wilfordii preparations alone can be greatly reduced or avoided.

The invention discloses a hydrogenation process for hydrogen peroxide production. The process comprises the following steps: (1) in a hydrogenation process for producing hydrogen peroxide by an anthraquinone process, arranging a hydrogenation tower I, a hydrogenation tower II and a hydrogenation tower III, and feeding hydrogen gas in three channels, i.e., hydrogen gas I, hydrogen gas II and hydrogen gas III; (2) mixing and dissolving working fluid feed and the hydrogen gas I in high-pressure gas dissolving equipment, and then, enabling the solution to enter the hydrogenation tower I for a first-stage hydrogenation reaction; (3) mixing and dissolving effluent of the first-stage hydrogenation reaction and the hydrogen gas II in the high-pressure gas dissolving equipment, and then, enabling the solution to enter the hydrogenation tower II for a second-stage hydrogenation reaction; (4) mixing and dissolving effluent of the second-stage hydrogenation reaction and the hydrogen gas III in the high-pressure gas dissolving equipment, and then, enabling the solution to enter the hydrogenation tower III for a third-stage hydrogenation reaction; and (5) enabling a material obtained after the third-stage hydrogenation reaction to flow out, carrying out gas-liquid separation, and going to next procedure. According to the process, through controlling the proportion of dissolved hydrogen, not only can a relatively high hydrogenation effect be achieved, but also minimal anthraquinone degradation products are obtained, so that the improvement on product concentration and device scale and the lowering of the consumption of a catalyst and anthraquinone are facilitated.

The invention provides a preparation method for a composite polysulfone membrane, belonging to the field of composite materials. The preparation method comprises the following steps: providing a basemembrane which is a dopamine in-situ polymerization doped polysulfone membrane and has a semi-interpenetrating type network structure; and crosslinking a chitosan copper complex onto the surface of the above-mention base membrane in a pulsed electric field environment so as to obtain the composite polysulfone membrane, wherein the above-mentioned composite polysulfone membrane has a contact angleof 45 degrees to 80 degrees, a pure water flux of 600 to 1250 L / m2.h and a rejection rate of at least 90%. The preparation method provided by the invention can increase the membrane pore size and water flux, limits membrane structure and mechanical properties from being destroyed due to agglomeration and water absorption of dopamine, reduces the attachment amount of organic substances in membranepores, improves membrane hydrophilicity and the rate of retention, reduces the decay rate of membrane pore flux and the increase coefficient of membrane resistance to improve pollution resistance, andreduces the replacement frequency of the composite membrane to save treatment cost; and the composite polysulfone membrane is used in the fields of marine aquaculture wastewater treatment, marine sterilization, red tide prevention and treatment, etc.

The invention discloses a medical suspended preparation and a preparation method thereof. The medical suspended preparation is used for treating and preventing diseases or regulating physiological functions through medical information without contacting human or animal body skins. The basic structure of the medical suspended preparation is composed of a medicament bank (1), a container (4) and a connecting piece (5). Contents (2) are medicaments having pharmacological activities. When the preparation is used in treatment, no medicinal material matters enter a human or animal body, so safety problem as well as the simulation of oral preparations to the gastrointestinal tract, the first-pass effect of the gastrointestinal tract, the drawbacks of pains, cross-infection risks and injection and infusion reactions of injections, the simulation and damage of transdermal patchs to skin, the damage of adhesive to skin, and the like are avoided. The product can be used repeatedly, so the consumption of medicaments is reduced greatly, medicament resources are saved, environmental pollution caused by pharmaceutical industry is reduced greatly, and ecological is protected. The preparation is simple, convenient and safe to use and is particularly suitable for treating the aged and weak, children, people with mental retardation and animals.

The invention relates to combined wave treatment equipment and treatment system. The combined wave treatment equipment comprises an ultrasonic wave generation unit (10), an impact wave generation unit(20) and a combined wave generator (30), wherein the ultrasonic wave generation unit (10) is used for generating therapeutic ultrasonic waves; the impact wave generation unit (20) is used for generating therapeutic impact waves; the combined wave generator (30) is coupled with the ultrasonic wave generation unit (10) and the impact wave generation unit (20) respectively and is used for combiningthe therapeutic ultrasonic waves and the therapeutic impact waves into combined waves and applying the combined waves to a part to be treated. By adopting the combined wave treatment equipment and treatment system, the treatment effect can be improved and the side effect of treatment waves is reduced.

The invention discloses a medicine composition mainly containing oral glucocorticoid and an oral bronchodilator, as well as application thereof in preparing medicines for treating chronic obstructive pulmonary diseases (COPD) and bronchial asthma, which belongs to the technical field of medicine preparations. The oral glucocorticoid contained in the medicine composition is prednisone, prednisolone or methylprednisolone, and the oral bronchodilator is formoterol, clenbuterol or euphylline. The curative effect of the composition for treating the COPD or the bronchial asthma is better than that of separately using the two composition ingredients one after another, and the composition has the characteristics of synergistic action and low cost. Thus, the combination preparation of the oral glucocorticoid and the oral bronchodilator is of great significance to the treatment and the prevention of the COPD and the bronchial asthma of patients of lower income groups in wide rural and urban areas in China.

The invention belongs to the technical field of veterinary medicament preparations, and particularly discloses a long-acting compound sulfamonomethoxine injection and a preparation method thereof. The long-acting compound sulfamonomethoxine injection is prepared from the following raw materials in percentage by weight: 8-12 percent of sulfamonomethoxine (SMM), 1-3 percent of trimethoprim (TMP), 40-55 percent of propylene glycol, 8-12 percent of ethanol, 1-3 percent of cholamine, 1-4 percent of benzyl alcohol, 1-4 percent of polyvinylpyrrolidone (PVP) and the balance of water for injection. In the long-acting compound sulfamonomethoxine injection, polyvinylpyrrolidone serving as a sustained-release material is added and is uniformly dispersed into a treatment medicament, so that the medicament can be released slowly after entering an animal body, the half-life period of the medicament is prolonged, effective blood concentration is maintained for a long time, side effects caused by 'peak valley' fluctuation of the blood concentration are reduced or avoided, and the aims of high efficiency, long-acting property and stability are fulfilled.

The invention provides tripterine nanometer lipid injection and a method for preparing same, wherein the nanometer lipid injection contains a active component of tripterine and a self-emulsifying medicament releasing system made from ester copolymer and phospholipid derivates, the nanometer lipid injection is oil in water type (O / W) microparticles, particle diameters of the nanometer microparticles is smaller than 200nm, and the medicament-carrying amount of the nanometer microparticles is large than 98%. The tripterine nanometer lipid injection provided by the invention is a new formulation, is an anti-tumor nanometer injection product, can substantially raise bioavailability of the medicaments in human body, and increase stability of the medicaments, and the preparation method is simple and suitable for large-scale production. The tripterine nanometer lipid injection provided by the invention can be applied to treat rheumatoid, senile dementia and tumor, and especially has a large market prospect for preventing and treating cancer.

The invention relates to a medicinal control release nanometer and method for making same, in particular a retinoic acid release control nanomicrosphere and its preparation method, the constituents of the composition are polylactic acid (PLA), vitamin A acid (RA) and gelatin aqueous solution.

The invention relates to the field of biomedical polymer materials and discloses a preparation method of a controlled release hydrogel for tumor postoperative radiotherapy in combination with photothermal-photodynamic therapy. The hydrogel which has a controlled release function and is used for the tumor postoperative radiotherapy in combination with the photothermal-photodynamic therapy is obtained by adopting silk fibroin loaded with copper sulfide@melanin-PEG@dopamine nanoparticles and a photosensitizer 5-aminolevulinic acid, wherein the silk fibroin has good biocompatibility, and the copper sulfide@melanin-PEG@dopamine nanoparticles have a great photothermal property and a good radiotherapy function. The hydrogel can be used for performing photothermal therapy, photodynamic therapy andradiation therapy on a postoperative tumor part. At the same time, the hydrogel has a good controlled release property and can achieve the effects of reducing the drug delivery dosage and reducing oravoiding toxic and side effects. The stability of drugs is improved, and the hydrogel is convenient to store; some new drug delivery routes can be established.