Inorganic-organic hybrid compound

A technology of organic hybridization and compounding, which is applied in the field of inorganic-organic hybridization compounds, and can solve problems such as side effects

Inactive Publication Date: 2017-05-10
KARLSRUHER INST FUR TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] - occurrence of side effects;

Method used

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  • Inorganic-organic hybrid compound
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  • Inorganic-organic hybrid compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Example 1: [ZrO][BMP] 0.9 [FMN] 0.1 :

[0074] Inorganic-organic hybrid compound ZrO(BMP) 0.9 (FMN) 0.1 Prepared by mixing two solutions. Solution 1 contained ZrOCl in demineralized water (2.5 mL) 2 ·8H 2 O (5 mg). Solution 2 contained riboflavin 5'-sodium monophosphate dihydrate (2.4 mg) and betamethasone sodium phosphate (21.6 mg) in demineralized water (25 mL). Solution 2 was heated to 50° C. and stirred vigorously (about 1000 rpm). Solution 1 was then injected rapidly with a syringe under intensive stirring. After stirring for two minutes, by centrifugation (at 22500Umin -1 15 minutes) a yellow solid separated. The nanoparticles were resuspended twice in demineralized water (25 mL) and centrifuged again to remove any remaining salts. Finally, a stable suspension was obtained by resuspending the nanoparticles in HEPES buffer (12 mL, 30 mmol / L, pH=7.4). Alternatively, the centrifugate was resuspended in demineralized water (3.1 mL). To this suspension was...

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Abstract

The invention relates to an inorganic-organic hybrid compound as an ion compound, composed of an inorganic cation and an organic anion active substance and optionally, an organic anion fluorescent dye.

Description

technical field [0001] The present invention relates to an inorganic-organic hybrid compound in the form of an ionic compound composed of an inorganic cation and an anion of an organic active ingredient and optionally an anion of an organic fluorescent dye. According to a simple water-based synthesis, a large group of inorganic-organic hybrid compound substances according to the invention can be obtained, which has a wide range of active ingredients and therapeutic bases (for example, inflammatory or immune disorders, such as rheumatism, arthritis, osteoporosis , multiple sclerosis; neurological disorders, such as epilepsy or schizophrenia; neoplastic disorders; infectious diseases (bacterial, viral, parasitic infections), such as malaria, tuberculosis or mycoses; cardiovascular disorders, such as angina pectoris or coronary artery deposits; for pain point treatment). Furthermore, combining active ingredient release with optical detection is easy to achieve. The inorganic-or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C237/26C07D401/04C07D403/10C07F5/06C07F7/00C07F9/09C07F9/58C07F9/655C07D401/10C07F9/6503C07F9/6506C07D417/12C07F9/12C07F9/6509C07C309/47C07D407/12C07F9/6574C07C309/50C07F9/6561C07D417/10C07F9/117C07F9/38C07H19/00A61K31/00C07D493/10C07F19/00C07F9/30C07F9/6533C07F9/6558C07D413/04
CPCC07C237/26C07C309/47C07D251/50C07D401/04C07D401/10C07D403/10C07D407/12C07D413/04C07D417/10C07D417/12C07D493/10C07F5/069C07F9/091C07F9/117C07F9/12C07F9/301C07F9/3813C07F9/3873C07F9/65335C07F9/65505C07F9/65515C07F9/65517C07F9/65522C07F9/65583C07F9/65586C07F9/6561C07F9/65744C07F9/65746C07J1/0033C07J51/00C09B11/08C09B19/00C09B23/06C09B23/086C09B29/16C09B31/072C09B31/08C09B35/023C09B55/006C09B55/009C09B57/00C09B57/02C09B57/08C09B62/085C09B63/005C09B1/02C09B1/52C07C2603/46C07F9/58C07F9/65031C07F9/6506C07F9/650952C07F7/003A61K31/185A61K31/427A61K31/519A61K31/546A61K31/569A61K31/65A61K31/661A61K31/6615A61K31/662A61K31/663A61K31/665A61K31/675A61K31/683A61K31/7008A61K31/704A61K31/7056A61K31/7068A61K31/7076A61K38/12A61P11/06A61P19/02A61P25/00A61P29/00A61P31/06A61P33/06A61P35/00A61P9/10Y02A50/30A61K47/02A61K49/0021A61K49/0032A61K49/0034A61K49/0036A61K49/0041
Inventor 乔辛·赫克马里克·波斯霍尔格·莱夏特乔安娜·纳普弗萝克·阿尔维斯瓦特·斯图马克劳斯·费尔德曼
Owner KARLSRUHER INST FUR TECH
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