76 results about "Hybrid compound" patented technology

Provided herein are aza-tetraepoxy aza # imgabs0 #-based compounds that are useful in the treatment of cancer.

Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes

The invention discloses an inorganic-organic hybrid compound crystal and a preparation method thereof, and belongs to the technical field of organic-inorganic hybrid materials. The preparation method comprises the following steps: mixing raw materials containing hydroiodic acid, organic cage molecules RCC3 and a lead source with a solvent, and carrying out solvothermal reaction to obtain the inorganic-organic hybrid compound crystal. The chemical formula of the prepared inorganic-organic hybrid compound crystal is ({H18 [C72H108N12] 2 [(Pb10I36)]}. 2I), wherein [C72H108N12] is RCC3 acidified by hydroiodic acid, the crystal has a supramolecular three-dimensional structure assembled by a [Pb5I8] 3-anion cluster unit and a protonated RCC3 molecular cage through electrostatic and hydrogen-bond interaction, and belongs to a monoclinic system, and the space group is P21. The crystal structure is a metal halide-based organic-inorganic hybrid crystal constructed by taking an organic molecular cage as nitrogen-containing cations and lead iodide for the first time.

The invention provides a phthalazinone compound, an intermediate and an organic electroluminescent device. The compound has a structure as shown in a formula I or a formula II. The intermediates are used for preparing the compounds. The structure of the compound is designed, so that the compound is suitable for being used as a main body material of a light-emitting layer of the organic light-emitting device, and the organic light-emitting device has relatively high current efficiency and relatively long service life.

Provided herein are processes for preparing Compound A or a salt thereof, comprising admixing Compound B or a salt thereof and crotonaldehyde in the presence of an acid catalyst and a solvent to form Compound A

Provided is a novel composition, in particular, a composition comprising an inorganic-organic hybrid compound. The composition comprises an inorganic-organic hybrid compound and a hydrophobic resin, wherein the inorganic-organic hybrid compound comprises a polyvinyl alcohol-based resin to which a metal oxide is chemically bonded.

The present invention provides heterocyclic compounds as TYK2 pseudokinase (JH2) domain inhibitors, synthesis methods and uses. Specifically, the present invention provides a heterocyclic compound as shown in Formula I or a pharmaceutically acceptable salt thereof, wherein each group is as defined in the text. The heterocyclic compound of the present invention has excellent TYK2 (JH2) selective inhibitory activity.

New selenated thiourea hybrid compounds are described herein, as well as the use of such selenated thiourea hybrid compounds in inhibiting corrosion of a steel material. Also described are methods for forming the new selenated thiourea hybrid compounds as well as anti-corrosion coatings containing the selenated thiourea hybrid compounds.

The invention relates to the technical field of dispersing agents, and particularly discloses a polycarboxylic acid type dispersing agent as well as a preparation method and application thereof. The preparation method comprises the following steps: polymerizing itaconic acid, 2-acrylamide-2-methylpropanesulfonic acid, glycidyl methacrylate, methyl styrene, gamma-methacryloxypropyltrimethoxysilane, the modified hybrid compound, vinyl 2-mercaptopropionate and allyl polyoxyethylene ether to obtain a polycarboxylic acid type dispersing agent; the dispersing agent has excellent dispersing performance and heat resistance, the dispersing agent is not prone to losing efficacy in the high-temperature vulcanization process in the rubber processing process, and when filler and rubber are mixed, the dispersing agent is firmly adsorbed on the surfaces of filler particles through multiple acting forces, so that the dispersing agent is not prone to losing efficacy, and the service life of the dispersing agent is prolonged. The dispersing performance of the filler and the interface bonding force with rubber are improved, so that the filler is uniformly distributed in the rubber, a stable dispersion system is formed, the mechanical property of vulcanized rubber is improved, and the processing fluidity is improved.

The invention discloses a synthesis method of a metal organic framework mesoporous material, which comprises the following steps: weighing a PEO-PPO-PEO triblock copolymer in deionized water, violently stirring to dissolve the PEO-PPO-PEO triblock copolymer, adding a hydrochloric acid solution, keeping the temperature at 35-40 DEG C for 0.5-1 hour, and slowly dropwise adding a mixed silicon source solution of tetraethoxysilane and organic silicon while violently stirring; stirring the reaction mixture at 35-40 DEG C for 20-30 hours to obtain turbid liquid with white particles, cooling the turbid liquid to room temperature, then transferring the turbid liquid into a high-pressure reaction kettle, and heating the turbid liquid in a drying oven at 110-120 DEG C for 40-60 hours; according to the synthesis method of the metal organic framework mesoporous material, a tripyrimidine structure is prepared into an organic silicon precursor, the organic silicon precursor reacts with a PEO-PPO-PEO triblock copolymer to prepare a mesoporous hybrid compound, and the mesoporous hybrid compound can be used for removing sulfonamide antibiotics in a water body and is applied to water body treatment.

The invention relates to the technical field of refrigeration air conditioners, in particular to an efficient environment-friendly low-GWP air conditioner refrigerant formula and a preparation method thereof. The technical problem that an existing low-GWP refrigerant is high in flammability is solved. According to the refrigerant formula prepared by the invention, a high-energy-efficiency natural working medium and an ultralow-GWP fourth-generation refrigerant are taken as main components, a small amount of phosphorus-nitrogen hybrid compound is added as a flame-retardant additive, and the main components are mixed under the conditions of low temperature and high pressure. The flame-retardant additive adopted by the invention has excellent flame retardance, and can capture free radicals and release inert gas to inhibit combustion chain reaction during combustion. Nanoscale dispersion of the additive is realized through a low-temperature ultrasonic-assisted microjet homogenization technology, and the stability of the components is ensured by utilizing online monitoring. According to the refrigerant prepared by the invention, the combustibility is greatly reduced while the refrigeration performance is ensured, and both low GWP and low combustibility are realized.

The utility model discloses a double-electromechanical-port double-modulation integrated type electromechanical composite compound planetary multi-source driving transmission system which comprises a double-electromechanical-port motor with a double-modulation composite integration effect, a differential planetary gear train, a compound planetary gear and a multi-gear parallel transmission structure. The double-electromechanical-port motor and the differential planetary gear train form an electromechanical composite transmission device of the double-electromechanical-port motor; a dual-modulation composite outer rotor of the dual-electromechanical-port motor serves as an outer mechanical port of the dual-electromechanical-port motor and also serves as a planet carrier input end of the differential planetary gear train. The front section of a gear shaft of the differential planetary gear train serves as an inner mechanical port of the double-electromechanical-port motor, the rear section of the gear shaft of the differential planetary gear train serves as a sun gear input end of the differential planetary gear train, and the differential planetary gear train is connected with the compound planetary gear through a shaft. The problems that in the prior art, energy loss is large, the size is large, a transmission chain is too long, unbalance loading is serious, and the transmission form is single can be solved.

The present specification provides a heterocyclic compound and an organic light-emitting element including the same.

Prepare a compound A containing Li, S, and M elements (M is phosphorus, etc.) and containing a crystal phase having an argyrodite-type crystal structure, and mix the compound A with a conductive material to obtain a composite material formed by compounding the two. In the XRD pattern of the compound A, the intensity of peak A observed at 2θ = 29.7° ± 1.00° is set as I0, and in the XRD pattern of the composite material, the intensity of peak B observed at 2θ = 29.7° ± 1.00° is set as I t When, the degree of amorphization N obtained by 100×(I0 - I t ) / I0 is mixed in such a way that it becomes 97% or more. It is suitable that the atomic ratio of the halogen (X) element contained in the compound A to the phosphorus (P) element is less than 1.0.

The present invention discloses a variable-valence metal mercapto two-dimensional coordination polymer, its preparation method and application. The method comprises the following steps: S1. Mix an inorganic metal salt and 4,4'-thiobis(phenethyl alcohol) in a mixed solvent of an ionic liquid, an organic amine, N,N-dimethylformamide and isopropanol. After complete dissolution, carry out an ionothermal reaction; S2. Separate the mixture after the ionothermal reaction, and then wash and dry the separated solid phase with an alcohol until a pure-phase colored or colorless octahedral crystal is obtained, namely, a variable-valence metal mercapto two-dimensional coordination polymer is obtained; the variable-valence metal mercapto two-dimensional coordination polymer is an organic-inorganic hybrid compound, which is a colored or colorless octahedral crystal and can be applied to catalytic, electrical conductance, and photothermal conversion devices.

The invention provides a preparation method and application of a near-infrared absorption electropositive carbon nitride nano-composite PEISECCNs, and relates to the technical field of biological medicines.The preparation method comprises the following steps that a nitrogen-containing precursor and a selenium-containing precursor are calcined under nitrogen protection to obtain a mixture, and the mixture is placed in mixed acid to react to obtain-COOH-SeCCNs modified by-COOH groups; and dissolving the obtained-COOH group modified COOH-SeCCNs and a branched chain PEI600, HOBT, HBTU and N, N-diisopropylethylamine in DMF (Dimethyl Formamide), carrying out an acylation reaction, and dialyzing to obtain a final product PEISeCCNs. The invention constructs the electropositive carbon nitride-based nano-composite PEISECCNs capable of absorbing near-infrared light, and the electropositive carbon nitride-based nano-composite PEISECCNs has good biocompatibility, is beneficial to application in the field of biomedicine, and can absorb near-infrared light. The carbon nitride-based nano-composite PEISeCCNs disclosed by the invention is mainly synthesized by high-temperature calcination, acidification and acylation reaction. The synthesis method is simple, good in repeatability and easy for industrial production, and is a brand-new hybrid compound.

The present invention relates to a method for preparing 2-methyltetrahydrofuran using a mixture of compounds derived from lignocellulosic biomass, a catalyst used therefor, and a method for preparing the catalyst. According to the present invention, 2-methyltetrahydrofuran can be prepared in high yield from a mixed lignocellulosic biomass-derived compound by performing a hydrogenation dehydration reaction using a furfural compound and a levulinic acid compound as reactants, and the effect can be maximized through optimization of the composition and reaction conditions of the reactants. In addition, the selectivity of 2-MTHF can be further improved by using a catalyst in which nickel and copper, which are non-noble metal-based materials, are supported on an acid support in the reaction.

The application discloses a steroid-indole alkaloid hybrid dimer compound, a preparation method thereof and application of the compound in preparation of an antitumor chemotherapy drug sensitizer, and first prepares the steroid-indole diketopiperazine alkaloid hybrid compound from a fungus Aspergillus sp. EGF15-0-3 rice culture medium. The compound is a new skeleton compound first discovered in nature. It is first discovered that the hybrid compound has Tdp1 inhibitory activity and can be applied as a tyrosine-DNA phosphodiesterase 1 (Tdp1) inhibitor. It is first discovered that the hybrid compound has chemotherapy sensitization activity on a tumor chemotherapy drug topotecan TPT, which provides a drug source molecule and data support for development of a new natural antitumor combination inhibitor, and has important significance for development and utilization of marine Aspergillus sp. fungus resources.

The present application provides a modified EVOH resin, which is obtained by that EVOH resin is blended with a hyperbranched polymer during an extrusion and granulation step and is modified by the hyperbranched polymer; wherein, the hyperbranched polymer is obtained by reacting a hybrid compound containing boron, silicon or titanium with a small organic molecule containing hydroxyl group. The modified EVOH resin can not only increase the branching degree of the EVOH resin and increase the radiation crosslinking frequency of the EVOH resin, but also effectively reduce the amount of boron-containing compound added and significantly improve the forming processing performance and heat resistance without changing the original preparation process.

The present invention relates to a novel polyethylene-vinyl acetate vitrimer. In an embodiment, the polyethylene-vinyl acetate vitrimer is manufactured from a composition comprising: a polyethylene-vinyl acetate copolymer; and a mixture of a first compound and a second compound, wherein the first and second compounds are represented by the following chemical formula 1 and chemical formula 2, respectively: [Chemical formula 1] M1(-O-L1-R1)n [Chemical formula 2] M2(-O-L2-R2)m (chemical formula 1 and chemical formula 2 are as described in the Detail Description). Unlike conventional crosslinked materials, the polyethylene-vinyl acetate vitrimer according to the present invention can be repeatedly recycled through a bond exchange reaction without a decomposition reaction such as pyrolysis, hydrolysis, and the like even when repeated thermoforming is performed,

The invention discloses a method for preparing a 4-amino-2-quinolinone compound through visible light catalysis of cyclization of 1, 6-alkene nitrile, which comprises the following steps: mixing a copper-based photosensitizer, a 1, 6-alkene nitrile compound as shown in a formula I, amine and a solvent in an inert atmosphere, reacting for 12-48 hours at 15-35 DEG C under illumination, and post-treating the reaction liquid to obtain the 4-amino-2-quinolinone compound as shown in a formula II, the method is mild, efficient, green and suitable for large-scale production; # imgabs0 #

The invention discloses a quantitative evaluation method for key compounds of reheated odor (WOF) of prefabricated braised pork in brown sauce. The quantitative evaluation method comprises the following steps: pretreating a sample to form a fresh group and a reheated group; performing smell detection and comparison on the two groups of samples by using an electronic nose, and identifying the flavor difference of the two groups of samples; carrying out headspace solid-phase microextraction to obtain a mixed compound, and carrying out gas chromatography-olfactory detection-mass spectrometry determination to obtain a main volatile compound of the sample; constructing a concentration-peak area standard curve of the main volatile compound, and calculating the concentration and odor activity value of the volatile compound; and constructing an odor recombination model and an odor omission test, and determining key constituent compounds of the WOF. The method provides a powerful technical support for improving and enhancing the overall flavor of the prefabricated braised pork in brown sauce.

The invention relates to a composition which can be fixed by actinic radiation and cured by heat, the composition comprising: (A) an at least bifunctional, passivated, and solid isocyanate; (B) an isocyanate-reactive component which comprises at least one liquid hybrid compound (B1) which, in addition to at least one isocyanate-reactive group, contains at least one radically curable group, the hybrid compound (B1) having a molar mass of at least 400 g / mol; and (C) an initiator system for radical polymerisation, which comprises a first initiator (C1) and a second initiator (C2), the first initiator (C1) being a radical photoinitiator and the second initiator (C2) being a radical initiator for heat curing. The invention also relates to a method for bonding, casting and / or coating substrates, and to a use of a curable composition.

The embodiment of the invention provides a manufacturing method of a semiconductor device and the semiconductor device, and the method comprises the steps: providing a substrate, forming a copper-containing metal structure prepared based on a Damascus technology on the substrate, and enabling the copper-containing metal structure to be ground through a chemical mechanical polishing technology; performing reduction treatment on the surface of the ground copper-containing metal structure by using first plasma; second plasma is introduced into the surface of the reduced copper-containing metal structure, and a compound layer is formed on the surface of the copper-containing metal structure; third plasma is introduced into the surface of the compound layer, and the compound layer is converted into a mixed compound layer; and sequentially depositing and forming a passivation layer and an oxide isolation layer on the mixed compound layer. The electromigration resistance of the copper metal layer is effectively improved.

The invention discloses a biphenyl-diketopiperazine indole alkaloid hybrid compound, which is separated from a fermentation product of a strain Aspergillus candidus HNNU0546, and has a skeleton molecule formed by hybridizing rare diketopiperazine indole alkaloid with biphenyl molecules through an isopentenylation branch chain, and the biphenyl compound can obviously inhibit the activity of crop disease fungi.

The present invention provides a nitrogen-containing fused heterocyclic compound and an application thereof. When the nitrogen-containing fused heterocyclic compound of the present invention is used as a main material of a light-emitting layer, an organic light-emitting device can have a lower driving voltage (3.8-4.1V), a higher current efficiency (above 15-23Cd / A) and a longer life (above 273h).

The invention belongs to the technical field of genetic engineering and biosynthesis, and particularly relates to a streptomyces-sourced siderophore-polyketone hybrid product synthesis related gene cluster, a genetically engineered bacterium and application of the genetically engineered bacterium. The invention provides an NIS siderophore synthetase gene cluster. The gene cluster is selected from a gene cluster BGC19 or a gene cluster desB. Meanwhile, the invention discloses two biological heterologous or ectopic expression engineering bacteria for producing the hybrid siderophore and application of the siderophore-polyketone hybrid compound by taking streptomyces as a host, and discloses structures and activities of the siderophore-polyketone hybrid compound produced by the two engineering bacteria. The invention provides a scheme for the construction of engineering bacteria for generating new hybrid compounds by utilizing the expression of non-adjacent gene clusters at specific sites and functional combination among the gene clusters, also provides a new element for the biosynthesis of a novel siderophore and polyketone combination, and has good practical application value.

A method is provided for assembling an LED lighting device. The method includes providing a polyurethane compound and mixing a diffuser compound with the polyurethane compound to form a combined compound. The method then includes injecting the combined compound into a cartridge, applying a vacuum to the cartridge, and sealing the cartridge at a first pressure lower than ambient pressure. The method then includes providing an LED lighting assembly having a front panel and a frame, the frame extending past the front panel to form an enclosed tray in a shape of the front panel. The combined compound is then dispensed from the cartridge into the enclosed tray.

New selenated thiourea hybrid compounds are described herein, as well as the use of such selenated thiourea hybrid compounds in inhibiting corrosion of a steel material. Also described are methods for forming the new selenated thiourea hybrid compounds as well as anti-corrosion coatings containing the selenated thiourea hybrid compounds.

The present invention discloses a method for preparing a C-C bond coupling product from an enol silyl ether compound and the application of SF6, belonging to the technical field of organic photochemistry. In this method, an enol silyl ether compound and sulfur hexafluoride undergo a photochemical reaction at room temperature under the action of a light source and a photocatalyst to form a C-C bond coupling product; wherein the photocatalyst is N-phenylphenothiazine (PTH); and the light source is ultraviolet light with a wavelength of 365nm. Beneficial effects: This method utilizes sulfur hexafluoride to promote C-C bond coupling, and the reaction product is a 1,4-dicarbonyl compound that can be used in the synthesis and production of hybrid compounds such as pyrrole and furan; the reaction conditions are mild, and the raw materials are simple and readily available, thus having potential application value.