56 results about "Hybrid compound" patented technology

Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes

The invention discloses an inorganic-organic hybrid compound crystal and a preparation method thereof, and belongs to the technical field of organic-inorganic hybrid materials. The preparation method comprises the following steps: mixing raw materials containing hydroiodic acid, organic cage molecules RCC3 and a lead source with a solvent, and carrying out solvothermal reaction to obtain the inorganic-organic hybrid compound crystal. The chemical formula of the prepared inorganic-organic hybrid compound crystal is ({H18 [C72H108N12] 2 [(Pb10I36)]}. 2I), wherein [C72H108N12] is RCC3 acidified by hydroiodic acid, the crystal has a supramolecular three-dimensional structure assembled by a [Pb5I8] 3-anion cluster unit and a protonated RCC3 molecular cage through electrostatic and hydrogen-bond interaction, and belongs to a monoclinic system, and the space group is P21. The crystal structure is a metal halide-based organic-inorganic hybrid crystal constructed by taking an organic molecular cage as nitrogen-containing cations and lead iodide for the first time.

Provided herein are processes for preparing Compound A or a salt thereof, comprising admixing Compound B or a salt thereof and crotonaldehyde in the presence of an acid catalyst and a solvent to form Compound A

The invention relates to the technical field of dispersing agents, and particularly discloses a polycarboxylic acid type dispersing agent as well as a preparation method and application thereof. The preparation method comprises the following steps: polymerizing itaconic acid, 2-acrylamide-2-methylpropanesulfonic acid, glycidyl methacrylate, methyl styrene, gamma-methacryloxypropyltrimethoxysilane, the modified hybrid compound, vinyl 2-mercaptopropionate and allyl polyoxyethylene ether to obtain a polycarboxylic acid type dispersing agent; the dispersing agent has excellent dispersing performance and heat resistance, the dispersing agent is not prone to losing efficacy in the high-temperature vulcanization process in the rubber processing process, and when filler and rubber are mixed, the dispersing agent is firmly adsorbed on the surfaces of filler particles through multiple acting forces, so that the dispersing agent is not prone to losing efficacy, and the service life of the dispersing agent is prolonged. The dispersing performance of the filler and the interface bonding force with rubber are improved, so that the filler is uniformly distributed in the rubber, a stable dispersion system is formed, the mechanical property of vulcanized rubber is improved, and the processing fluidity is improved.

The invention discloses a synthesis method of a metal organic framework mesoporous material, which comprises the following steps: weighing a PEO-PPO-PEO triblock copolymer in deionized water, violently stirring to dissolve the PEO-PPO-PEO triblock copolymer, adding a hydrochloric acid solution, keeping the temperature at 35-40 DEG C for 0.5-1 hour, and slowly dropwise adding a mixed silicon source solution of tetraethoxysilane and organic silicon while violently stirring; stirring the reaction mixture at 35-40 DEG C for 20-30 hours to obtain turbid liquid with white particles, cooling the turbid liquid to room temperature, then transferring the turbid liquid into a high-pressure reaction kettle, and heating the turbid liquid in a drying oven at 110-120 DEG C for 40-60 hours; according to the synthesis method of the metal organic framework mesoporous material, a tripyrimidine structure is prepared into an organic silicon precursor, the organic silicon precursor reacts with a PEO-PPO-PEO triblock copolymer to prepare a mesoporous hybrid compound, and the mesoporous hybrid compound can be used for removing sulfonamide antibiotics in a water body and is applied to water body treatment.

The invention relates to the technical field of refrigeration air conditioners, in particular to an efficient environment-friendly low-GWP air conditioner refrigerant formula and a preparation method thereof. The technical problem that an existing low-GWP refrigerant is high in flammability is solved. According to the refrigerant formula prepared by the invention, a high-energy-efficiency natural working medium and an ultralow-GWP fourth-generation refrigerant are taken as main components, a small amount of phosphorus-nitrogen hybrid compound is added as a flame-retardant additive, and the main components are mixed under the conditions of low temperature and high pressure. The flame-retardant additive adopted by the invention has excellent flame retardance, and can capture free radicals and release inert gas to inhibit combustion chain reaction during combustion. Nanoscale dispersion of the additive is realized through a low-temperature ultrasonic-assisted microjet homogenization technology, and the stability of the components is ensured by utilizing online monitoring. According to the refrigerant prepared by the invention, the combustibility is greatly reduced while the refrigeration performance is ensured, and both low GWP and low combustibility are realized.

The utility model discloses a double-electromechanical-port double-modulation integrated type electromechanical composite compound planetary multi-source driving transmission system which comprises a double-electromechanical-port motor with a double-modulation composite integration effect, a differential planetary gear train, a compound planetary gear and a multi-gear parallel transmission structure. The double-electromechanical-port motor and the differential planetary gear train form an electromechanical composite transmission device of the double-electromechanical-port motor; a dual-modulation composite outer rotor of the dual-electromechanical-port motor serves as an outer mechanical port of the dual-electromechanical-port motor and also serves as a planet carrier input end of the differential planetary gear train. The front section of a gear shaft of the differential planetary gear train serves as an inner mechanical port of the double-electromechanical-port motor, the rear section of the gear shaft of the differential planetary gear train serves as a sun gear input end of the differential planetary gear train, and the differential planetary gear train is connected with the compound planetary gear through a shaft. The problems that in the prior art, energy loss is large, the size is large, a transmission chain is too long, unbalance loading is serious, and the transmission form is single can be solved.

Prepare a compound A containing Li, S, and M elements (M is phosphorus, etc.) and containing a crystal phase having an argyrodite-type crystal structure, and mix the compound A with a conductive material to obtain a composite material formed by compounding the two. In the XRD pattern of the compound A, the intensity of peak A observed at 2θ = 29.7° ± 1.00° is set as I0, and in the XRD pattern of the composite material, the intensity of peak B observed at 2θ = 29.7° ± 1.00° is set as I t When, the degree of amorphization N obtained by 100×(I0 - I t ) / I0 is mixed in such a way that it becomes 97% or more. It is suitable that the atomic ratio of the halogen (X) element contained in the compound A to the phosphorus (P) element is less than 1.0.

The present invention discloses a variable-valence metal mercapto two-dimensional coordination polymer, its preparation method and application. The method comprises the following steps: S1. Mix an inorganic metal salt and 4,4'-thiobis(phenethyl alcohol) in a mixed solvent of an ionic liquid, an organic amine, N,N-dimethylformamide and isopropanol. After complete dissolution, carry out an ionothermal reaction; S2. Separate the mixture after the ionothermal reaction, and then wash and dry the separated solid phase with an alcohol until a pure-phase colored or colorless octahedral crystal is obtained, namely, a variable-valence metal mercapto two-dimensional coordination polymer is obtained; the variable-valence metal mercapto two-dimensional coordination polymer is an organic-inorganic hybrid compound, which is a colored or colorless octahedral crystal and can be applied to catalytic, electrical conductance, and photothermal conversion devices.

The present invention relates to a method for preparing 2-methyltetrahydrofuran using a mixture of compounds derived from lignocellulosic biomass, a catalyst used therefor, and a method for preparing the catalyst. According to the present invention, 2-methyltetrahydrofuran can be prepared in high yield from a mixed lignocellulosic biomass-derived compound by performing a hydrogenation dehydration reaction using a furfural compound and a levulinic acid compound as reactants, and the effect can be maximized through optimization of the composition and reaction conditions of the reactants. In addition, the selectivity of 2-MTHF can be further improved by using a catalyst in which nickel and copper, which are non-noble metal-based materials, are supported on an acid support in the reaction.

The application discloses a steroid-indole alkaloid hybrid dimer compound, a preparation method thereof and application of the compound in preparation of an antitumor chemotherapy drug sensitizer, and first prepares the steroid-indole diketopiperazine alkaloid hybrid compound from a fungus Aspergillus sp. EGF15-0-3 rice culture medium. The compound is a new skeleton compound first discovered in nature. It is first discovered that the hybrid compound has Tdp1 inhibitory activity and can be applied as a tyrosine-DNA phosphodiesterase 1 (Tdp1) inhibitor. It is first discovered that the hybrid compound has chemotherapy sensitization activity on a tumor chemotherapy drug topotecan TPT, which provides a drug source molecule and data support for development of a new natural antitumor combination inhibitor, and has important significance for development and utilization of marine Aspergillus sp. fungus resources.

The present application provides a modified EVOH resin, which is obtained by that EVOH resin is blended with a hyperbranched polymer during an extrusion and granulation step and is modified by the hyperbranched polymer; wherein, the hyperbranched polymer is obtained by reacting a hybrid compound containing boron, silicon or titanium with a small organic molecule containing hydroxyl group. The modified EVOH resin can not only increase the branching degree of the EVOH resin and increase the radiation crosslinking frequency of the EVOH resin, but also effectively reduce the amount of boron-containing compound added and significantly improve the forming processing performance and heat resistance without changing the original preparation process.

The present invention relates to a novel polyethylene-vinyl acetate vitrimer. In an embodiment, the polyethylene-vinyl acetate vitrimer is manufactured from a composition comprising: a polyethylene-vinyl acetate copolymer; and a mixture of a first compound and a second compound, wherein the first and second compounds are represented by the following chemical formula 1 and chemical formula 2, respectively: [Chemical formula 1] M1(-O-L1-R1)n [Chemical formula 2] M2(-O-L2-R2)m (chemical formula 1 and chemical formula 2 are as described in the Detail Description). Unlike conventional crosslinked materials, the polyethylene-vinyl acetate vitrimer according to the present invention can be repeatedly recycled through a bond exchange reaction without a decomposition reaction such as pyrolysis, hydrolysis, and the like even when repeated thermoforming is performed,

The invention discloses a quantitative evaluation method for key compounds of reheated odor (WOF) of prefabricated braised pork in brown sauce. The quantitative evaluation method comprises the following steps: pretreating a sample to form a fresh group and a reheated group; performing smell detection and comparison on the two groups of samples by using an electronic nose, and identifying the flavor difference of the two groups of samples; carrying out headspace solid-phase microextraction to obtain a mixed compound, and carrying out gas chromatography-olfactory detection-mass spectrometry determination to obtain a main volatile compound of the sample; constructing a concentration-peak area standard curve of the main volatile compound, and calculating the concentration and odor activity value of the volatile compound; and constructing an odor recombination model and an odor omission test, and determining key constituent compounds of the WOF. The method provides a powerful technical support for improving and enhancing the overall flavor of the prefabricated braised pork in brown sauce.

The invention relates to a composition which can be fixed by actinic radiation and cured by heat, the composition comprising: (A) an at least bifunctional, passivated, and solid isocyanate; (B) an isocyanate-reactive component which comprises at least one liquid hybrid compound (B1) which, in addition to at least one isocyanate-reactive group, contains at least one radically curable group, the hybrid compound (B1) having a molar mass of at least 400 g / mol; and (C) an initiator system for radical polymerisation, which comprises a first initiator (C1) and a second initiator (C2), the first initiator (C1) being a radical photoinitiator and the second initiator (C2) being a radical initiator for heat curing. The invention also relates to a method for bonding, casting and / or coating substrates, and to a use of a curable composition.

The invention discloses a biphenyl-diketopiperazine indole alkaloid hybrid compound, which is separated from a fermentation product of a strain Aspergillus candidus HNNU0546, and has a skeleton molecule formed by hybridizing rare diketopiperazine indole alkaloid with biphenyl molecules through an isopentenylation branch chain, and the biphenyl compound can obviously inhibit the activity of crop disease fungi.

The invention belongs to the technical field of genetic engineering and biosynthesis, and particularly relates to a streptomyces-sourced siderophore-polyketone hybrid product synthesis related gene cluster, a genetically engineered bacterium and application of the genetically engineered bacterium. The invention provides an NIS siderophore synthetase gene cluster. The gene cluster is selected from a gene cluster BGC19 or a gene cluster desB. Meanwhile, the invention discloses two biological heterologous or ectopic expression engineering bacteria for producing the hybrid siderophore and application of the siderophore-polyketone hybrid compound by taking streptomyces as a host, and discloses structures and activities of the siderophore-polyketone hybrid compound produced by the two engineering bacteria. The invention provides a scheme for the construction of engineering bacteria for generating new hybrid compounds by utilizing the expression of non-adjacent gene clusters at specific sites and functional combination among the gene clusters, also provides a new element for the biosynthesis of a novel siderophore and polyketone combination, and has good practical application value.

A method is provided for assembling an LED lighting device. The method includes providing a polyurethane compound and mixing a diffuser compound with the polyurethane compound to form a combined compound. The method then includes injecting the combined compound into a cartridge, applying a vacuum to the cartridge, and sealing the cartridge at a first pressure lower than ambient pressure. The method then includes providing an LED lighting assembly having a front panel and a frame, the frame extending past the front panel to form an enclosed tray in a shape of the front panel. The combined compound is then dispensed from the cartridge into the enclosed tray.

The present invention discloses a method for preparing a C-C bond coupling product from an enol silyl ether compound and the application of SF6, belonging to the technical field of organic photochemistry. In this method, an enol silyl ether compound and sulfur hexafluoride undergo a photochemical reaction at room temperature under the action of a light source and a photocatalyst to form a C-C bond coupling product; wherein the photocatalyst is N-phenylphenothiazine (PTH); and the light source is ultraviolet light with a wavelength of 365nm. Beneficial effects: This method utilizes sulfur hexafluoride to promote C-C bond coupling, and the reaction product is a 1,4-dicarbonyl compound that can be used in the synthesis and production of hybrid compounds such as pyrrole and furan; the reaction conditions are mild, and the raw materials are simple and readily available, thus having potential application value.

The present invention relates to an inorganic-organic hybrid compound as ionic compound, composed of an inorganic metal cation selected from [ZrO]2+, and of an organic active ingredient anion selected from gemcitabine monophosphate or gemcitabine triphosphate.

The invention belongs to the technical field of detection of organophosphorus pesticide residues in agricultural products, and particularly relates to a dual-mode detection method of isocarbophos, which comprises the following steps: mixing Fe3O4 (at) Cu-BTC / Apt, CS / S and N-CDs, adding an STE buffer solution, incubating to form a hybrid compound Fe3O4 (at) Cu-BTC / Apt-CS / S and N-CDs, and removing unreacted CS / S and N-CDs through magnetic separation; washing the compound, and resuspending the compound in a PBS buffer solution; adding an ICP (inductively coupled plasma) solution into the buffer solution, incubating, and removing supernate through magnetic separation to obtain a precipitate; and adding a HAc-NaAc buffer solution, an OPD solution and an H2O2 solution into the precipitate, fully reacting, measuring the absorbance value of the reaction system at 450 nm, and measuring the fluorescence intensities at 465 nm and 575 nm under the excitation wavelength of 390 nm. Two independent detection results of colorimetric and ratiometric fluorescence can be mutually verified, so that the results are more accurate, and false positive and false negative results are avoided; a colorimetric mode provides a result which can be observed by naked eyes, and a ratio fluorescence mode ensures high sensitivity of a detection result; finally, the dual-mode detection method has the advantages of simplicity, convenience, high accuracy, high sensitivity and the like.

The present invention discloses cationic guanidine based peptides, oligomers, and oligomer-peptide hybrid compounds, and also envisages within its scope monomers for obtaining peptides, oligomers and oligomer-peptide hybrid compounds, and the processes thereof. The present invention additionally relates to the composition for administration of the compounds and their utility as antimicrobial, antifungal agent and as a carrier therapeutic molecules for drug delivery applications.

Composition comprising an antibacterial benzimidazole-pyrazole hybrid compound, N-(1H-Benzo[d]imidazol-2-yl)-1-(3-(4-Fluorphenyl)-1-phenyl-1H-pyrazole-4-yl)methanimin (AJ01), characterized at a minimum inhibitory concentration of 12.5 µg / ml against Staphylococcus aureus, including multi-resistant strains, and with predicted high affinity for bacterial target proteins.

The invention represents new hybrid compounds of two natural products sclareol and doxorubicin in the form of their conjugates. These compounds are in the form of conjugates, where doxorubicin and sclareol are covalently linked by a linker in a 1:1 molar ratio. The hybrids have shown to possess anticancer properties and are effective in treating resistant cancer cells that have P-glycoprotein membrane transporter, responsible for resistance to doxorubicin. The hybrids have been tested on different types of cell lines, including human glioblastoma, non-small cell lung carcinoma, and colorectal carcinoma. Also, a method for their preparation and their use in medical products or pharmaceutical preparations has been determined. The results of the study include the cytotoxic activity of single, combined, and conjugated compounds in pairs of sensitive and resistant cancer cells, with and without P-glycoprotein expression. The selectivity towards cancer cells was determined by comparing with commercially available normal human lung fibroblast cells. The study also investigated the nanoparticle nature of hybrid compounds, their intracellular localization and toxicity in vivo.

The invention relates to a hybrid compounded robotic platform (HCRP) comprising: a support base; at least one robot arm with multiple degrees of freedom projected from the support base; at least one primary end‐effector, which may be adapted to carry and drive one or more secondary and tertiary end‐effectors; at least one coupler for establishing connections between the end‐effectors; at least one parking station for stowing end‐effectors; and an intelligent management unit to control the platform and / or the plurality of platforms.

The invention discloses a preparation method of a single-phase fluorinated liquid, and belongs to the technical field of liquid cooling. The method comprises the following steps: mixing a hexafluoropropylene tripolymer (a compound II), 2, 2, 3, 3, 4, 4, 5, 5-octafluoro-1-pentanol (a compound III), a basic catalyst and a polar solvent according to a molar ratio of the compound III to the compound II of 1: (3-10), and carrying out a reaction to obtain perfluorononyl 2, 2, 3, 3, 4, 4, 5, 5-octafluoropentyl ether (a compound I), the basic catalyst being an inorganic basic composite catalyst. The preparation method is simple in process and easy to operate, the obtained product is high in purity, and the cost advantage is excellent.

The present invention relates to a method for detecting a target nucleic acid in a sample by means of a competitive hybrid-based signaling assay. The method can be usefully employed to detect a single or a plurality of target nucleic acids by utilizing the competitive formation of a first hybrid compound and a second hybrid compound.

This invention provides a coumarin-chalcone hybrid compound, its preparation method, and its applications. The structure of the coumarin-chalcone hybrid compound is shown in Formula I. The coumarin-chalcone hybrid compound provided by this invention has a simple and easy synthesis process, readily available raw materials, and can significantly activate the transcriptional activity of Nrf2 at both the cellular and animal levels. It exhibits high safety, good cell membrane permeability, and can be taken orally. After oral administration, it primarily results in high exposure in the liver and can effectively alleviate liver damage caused by acetaminophen and alcohol.

The invention discloses an application method of fresh polypeptide in fresh extraction and salt reduction of chicken essence, and belongs to the field of food. The application method comprises the following steps: adding a compound protein fresh polypeptide solution into a Maillard reaction base material, adjusting the pH value of the solution to 7-7.5, placing the solution at 105-120 DEG C, reacting for 2-3 hours to obtain a compound flavor peptide solution, and concentrating, freezing and drying the compound flavor peptide solution to obtain the fresh polypeptide seasoning. And (2) adding chicken powder, monosodium glutamate, edible salt, white granulated sugar and disodium 5 '-ribonucleotide into the fresh polypeptide seasoning in the step (1), uniformly mixing to obtain a mixture, dishing, drying, crushing, and sieving with a 60-mesh sieve to obtain the compound freshness-improving and salt-reducing chicken essence. A large number of volatile hybrid compounds and special volatile flavoring substances are generated through the Maillard reaction, so that the food is endowed with unique fragrance and taste, and meanwhile, the intake of salt is reduced.

The present application relates to a kind of polyketide alkaloid hybrid compound and its preparation method and application, wherein, the polyketide alkaloid hybrid compound is selected from at least one of the compounds with the structural formula shown in formula I.The compound 1~6 structure includes an atypical angular anthracene ring polyketide ring and open-loop ternary nitrogen ring, both are novel compounds of skeleton.The polyketide alkaloid hybrid compound of the present application has the activity of inhibiting neuraminidase and influenza virus H1N1 and H3N2, and can be used for preparing anti-influenza virus drugs;Meanwhile, it also has the activity of resisting bacteria and actinomycetes, and can be used for preparing antibacterial agent, with good application prospect.