39 results about "Hybrid compound" patented technology

Provided herein is a process for preparing compound A comprising (a) admixing 2-isopropyl-4-methylpyridin-3-amine (Compound B), or a salt thereof, a first base, and a reactive compound comprising phosgene or a phosgene equivalent in an organic solvent to form 3-isocyanato-2-isopropyl-4-methylpyridine (Compound C); (b) admixing Compound C and 2,6-dichloro-5-fluoronicotinamide (Compound D) to form 2,6-dichloro-5-fluoro-N-((2-isopropyl-4-methylpyridin-3-yl)carbamoyl)nicotinamide (Compound E); and (c) admixing Compound E and a second base to form a product mixture comprising Compound A and the second base. Also provided herein is a process for synthesizing AMG 510 comprising using Compound A prepared according to the disclosed processes

Provided herein are processes for preparing Compound A or a salt thereof, comprising admixing Compound B or a salt thereof and crotonaldehyde in the presence of an acid catalyst and a solvent to form Compound A

The invention relates to the technical field of dispersing agents, and particularly discloses a polycarboxylic acid type dispersing agent as well as a preparation method and application thereof. The preparation method comprises the following steps: polymerizing itaconic acid, 2-acrylamide-2-methylpropanesulfonic acid, glycidyl methacrylate, methyl styrene, gamma-methacryloxypropyltrimethoxysilane, the modified hybrid compound, vinyl 2-mercaptopropionate and allyl polyoxyethylene ether to obtain a polycarboxylic acid type dispersing agent; the dispersing agent has excellent dispersing performance and heat resistance, the dispersing agent is not prone to losing efficacy in the high-temperature vulcanization process in the rubber processing process, and when filler and rubber are mixed, the dispersing agent is firmly adsorbed on the surfaces of filler particles through multiple acting forces, so that the dispersing agent is not prone to losing efficacy, and the service life of the dispersing agent is prolonged. The dispersing performance of the filler and the interface bonding force with rubber are improved, so that the filler is uniformly distributed in the rubber, a stable dispersion system is formed, the mechanical property of vulcanized rubber is improved, and the processing fluidity is improved.

The invention relates to the technical field of refrigeration air conditioners, in particular to an efficient environment-friendly low-GWP air conditioner refrigerant formula and a preparation method thereof. The technical problem that an existing low-GWP refrigerant is high in flammability is solved. According to the refrigerant formula prepared by the invention, a high-energy-efficiency natural working medium and an ultralow-GWP fourth-generation refrigerant are taken as main components, a small amount of phosphorus-nitrogen hybrid compound is added as a flame-retardant additive, and the main components are mixed under the conditions of low temperature and high pressure. The flame-retardant additive adopted by the invention has excellent flame retardance, and can capture free radicals and release inert gas to inhibit combustion chain reaction during combustion. Nanoscale dispersion of the additive is realized through a low-temperature ultrasonic-assisted microjet homogenization technology, and the stability of the components is ensured by utilizing online monitoring. According to the refrigerant prepared by the invention, the combustibility is greatly reduced while the refrigeration performance is ensured, and both low GWP and low combustibility are realized.

The utility model discloses a double-electromechanical-port double-modulation integrated type electromechanical composite compound planetary multi-source driving transmission system which comprises a double-electromechanical-port motor with a double-modulation composite integration effect, a differential planetary gear train, a compound planetary gear and a multi-gear parallel transmission structure. The double-electromechanical-port motor and the differential planetary gear train form an electromechanical composite transmission device of the double-electromechanical-port motor; a dual-modulation composite outer rotor of the dual-electromechanical-port motor serves as an outer mechanical port of the dual-electromechanical-port motor and also serves as a planet carrier input end of the differential planetary gear train. The front section of a gear shaft of the differential planetary gear train serves as an inner mechanical port of the double-electromechanical-port motor, the rear section of the gear shaft of the differential planetary gear train serves as a sun gear input end of the differential planetary gear train, and the differential planetary gear train is connected with the compound planetary gear through a shaft. The problems that in the prior art, energy loss is large, the size is large, a transmission chain is too long, unbalance loading is serious, and the transmission form is single can be solved.

The application discloses a steroid-indole alkaloid hybrid dimer compound, a preparation method thereof and application of the compound in preparation of an antitumor chemotherapy drug sensitizer, and first prepares the steroid-indole diketopiperazine alkaloid hybrid compound from a fungus Aspergillus sp. EGF15-0-3 rice culture medium. The compound is a new skeleton compound first discovered in nature. It is first discovered that the hybrid compound has Tdp1 inhibitory activity and can be applied as a tyrosine-DNA phosphodiesterase 1 (Tdp1) inhibitor. It is first discovered that the hybrid compound has chemotherapy sensitization activity on a tumor chemotherapy drug topotecan TPT, which provides a drug source molecule and data support for development of a new natural antitumor combination inhibitor, and has important significance for development and utilization of marine Aspergillus sp. fungus resources.

The invention discloses a quantitative evaluation method for key compounds of reheated odor (WOF) of prefabricated braised pork in brown sauce. The quantitative evaluation method comprises the following steps: pretreating a sample to form a fresh group and a reheated group; performing smell detection and comparison on the two groups of samples by using an electronic nose, and identifying the flavor difference of the two groups of samples; carrying out headspace solid-phase microextraction to obtain a mixed compound, and carrying out gas chromatography-olfactory detection-mass spectrometry determination to obtain a main volatile compound of the sample; constructing a concentration-peak area standard curve of the main volatile compound, and calculating the concentration and odor activity value of the volatile compound; and constructing an odor recombination model and an odor omission test, and determining key constituent compounds of the WOF. The method provides a powerful technical support for improving and enhancing the overall flavor of the prefabricated braised pork in brown sauce.

The invention relates to a composition which can be fixed by actinic radiation and cured by heat, the composition comprising: (A) an at least bifunctional, passivated, and solid isocyanate; (B) an isocyanate-reactive component which comprises at least one liquid hybrid compound (B1) which, in addition to at least one isocyanate-reactive group, contains at least one radically curable group, the hybrid compound (B1) having a molar mass of at least 400 g / mol; and (C) an initiator system for radical polymerisation, which comprises a first initiator (C1) and a second initiator (C2), the first initiator (C1) being a radical photoinitiator and the second initiator (C2) being a radical initiator for heat curing. The invention also relates to a method for bonding, casting and / or coating substrates, and to a use of a curable composition.

The invention discloses a biphenyl-diketopiperazine indole alkaloid hybrid compound, which is separated from a fermentation product of a strain Aspergillus candidus HNNU0546, and has a skeleton molecule formed by hybridizing rare diketopiperazine indole alkaloid with biphenyl molecules through an isopentenylation branch chain, and the biphenyl compound can obviously inhibit the activity of crop disease fungi.

The invention belongs to the technical field of genetic engineering and biosynthesis, and particularly relates to a streptomyces-sourced siderophore-polyketone hybrid product synthesis related gene cluster, a genetically engineered bacterium and application of the genetically engineered bacterium. The invention provides an NIS siderophore synthetase gene cluster. The gene cluster is selected from a gene cluster BGC19 or a gene cluster desB. Meanwhile, the invention discloses two biological heterologous or ectopic expression engineering bacteria for producing the hybrid siderophore and application of the siderophore-polyketone hybrid compound by taking streptomyces as a host, and discloses structures and activities of the siderophore-polyketone hybrid compound produced by the two engineering bacteria. The invention provides a scheme for the construction of engineering bacteria for generating new hybrid compounds by utilizing the expression of non-adjacent gene clusters at specific sites and functional combination among the gene clusters, also provides a new element for the biosynthesis of a novel siderophore and polyketone combination, and has good practical application value.

The present invention discloses a method for preparing a C-C bond coupling product from an enol silyl ether compound and the application of SF6, belonging to the technical field of organic photochemistry. In this method, an enol silyl ether compound and sulfur hexafluoride undergo a photochemical reaction at room temperature under the action of a light source and a photocatalyst to form a C-C bond coupling product; wherein the photocatalyst is N-phenylphenothiazine (PTH); and the light source is ultraviolet light with a wavelength of 365nm. Beneficial effects: This method utilizes sulfur hexafluoride to promote C-C bond coupling, and the reaction product is a 1,4-dicarbonyl compound that can be used in the synthesis and production of hybrid compounds such as pyrrole and furan; the reaction conditions are mild, and the raw materials are simple and readily available, thus having potential application value.

The present invention relates to an inorganic-organic hybrid compound as ionic compound, composed of an inorganic metal cation selected from [ZrO]2+, and of an organic active ingredient anion selected from gemcitabine monophosphate or gemcitabine triphosphate.

The present invention discloses cationic guanidine based peptides, oligomers, and oligomer-peptide hybrid compounds, and also envisages within its scope monomers for obtaining peptides, oligomers and oligomer-peptide hybrid compounds, and the processes thereof. The present invention additionally relates to the composition for administration of the compounds and their utility as antimicrobial, antifungal agent and as a carrier therapeutic molecules for drug delivery applications.

Composition comprising an antibacterial benzimidazole-pyrazole hybrid compound, N-(1H-Benzo[d]imidazol-2-yl)-1-(3-(4-Fluorphenyl)-1-phenyl-1H-pyrazole-4-yl)methanimin (AJ01), characterized at a minimum inhibitory concentration of 12.5 µg / ml against Staphylococcus aureus, including multi-resistant strains, and with predicted high affinity for bacterial target proteins.

The invention represents new hybrid compounds of two natural products sclareol and doxorubicin in the form of their conjugates. These compounds are in the form of conjugates, where doxorubicin and sclareol are covalently linked by a linker in a 1:1 molar ratio. The hybrids have shown to possess anticancer properties and are effective in treating resistant cancer cells that have P-glycoprotein membrane transporter, responsible for resistance to doxorubicin. The hybrids have been tested on different types of cell lines, including human glioblastoma, non-small cell lung carcinoma, and colorectal carcinoma. Also, a method for their preparation and their use in medical products or pharmaceutical preparations has been determined. The results of the study include the cytotoxic activity of single, combined, and conjugated compounds in pairs of sensitive and resistant cancer cells, with and without P-glycoprotein expression. The selectivity towards cancer cells was determined by comparing with commercially available normal human lung fibroblast cells. The study also investigated the nanoparticle nature of hybrid compounds, their intracellular localization and toxicity in vivo.

The invention relates to a hybrid compounded robotic platform (HCRP) comprising: a support base; at least one robot arm with multiple degrees of freedom projected from the support base; at least one primary end‐effector, which may be adapted to carry and drive one or more secondary and tertiary end‐effectors; at least one coupler for establishing connections between the end‐effectors; at least one parking station for stowing end‐effectors; and an intelligent management unit to control the platform and / or the plurality of platforms.

The invention discloses a preparation method of a single-phase fluorinated liquid, and belongs to the technical field of liquid cooling. The method comprises the following steps: mixing a hexafluoropropylene tripolymer (a compound II), 2, 2, 3, 3, 4, 4, 5, 5-octafluoro-1-pentanol (a compound III), a basic catalyst and a polar solvent according to a molar ratio of the compound III to the compound II of 1: (3-10), and carrying out a reaction to obtain perfluorononyl 2, 2, 3, 3, 4, 4, 5, 5-octafluoropentyl ether (a compound I), the basic catalyst being an inorganic basic composite catalyst. The preparation method is simple in process and easy to operate, the obtained product is high in purity, and the cost advantage is excellent.

The present invention relates to a method for detecting a target nucleic acid in a sample by means of a competitive hybrid-based signaling assay. The method can be usefully employed to detect a single or a plurality of target nucleic acids by utilizing the competitive formation of a first hybrid compound and a second hybrid compound.

This invention provides a coumarin-chalcone hybrid compound, its preparation method, and its applications. The structure of the coumarin-chalcone hybrid compound is shown in Formula I. The coumarin-chalcone hybrid compound provided by this invention has a simple and easy synthesis process, readily available raw materials, and can significantly activate the transcriptional activity of Nrf2 at both the cellular and animal levels. It exhibits high safety, good cell membrane permeability, and can be taken orally. After oral administration, it primarily results in high exposure in the liver and can effectively alleviate liver damage caused by acetaminophen and alcohol.

The present application relates to a kind of polyketide alkaloid hybrid compound and its preparation method and application, wherein, the polyketide alkaloid hybrid compound is selected from at least one of the compounds with the structural formula shown in formula I.The compound 1~6 structure includes an atypical angular anthracene ring polyketide ring and open-loop ternary nitrogen ring, both are novel compounds of skeleton.The polyketide alkaloid hybrid compound of the present application has the activity of inhibiting neuraminidase and influenza virus H1N1 and H3N2, and can be used for preparing anti-influenza virus drugs;Meanwhile, it also has the activity of resisting bacteria and actinomycetes, and can be used for preparing antibacterial agent, with good application prospect.

The invention discloses a gradient distribution self-repairing carbon fiber-polymer composite material and a preparation method thereof, and belongs to the technical field of polymer composite materials. The material is composed of three functional gradient areas of a lower layer surface, a middle transition area and an upper layer surface, the performance optimization of each region is realized through the differentiated ratio of the carbon fiber, the epoxy Vitrimer resin, the dynamic disulfide bond siloxane hybrid compound, the supramolecular hydrogen bond metal coordination bifunctional polymer and the catalyst. The preparation method comprises the following steps: carrying out oxidation and interface functionalization pretreatment on the carbon fiber fabric, respectively preparing slurry in different areas, realizing component gradient distribution by adopting a centrifugal forming technology, and shaping the material by adopting a segmented curing process. Through the unique gradient distribution design and the synergistic effect of the two novel self-repairing compounds, the contradiction between the mechanical property and the self-repairing efficiency of the material is effectively solved, the material is endowed with excellent multi-time self-repairing capacity and high strength and toughness, and the material has outstanding advantages in manufacturing of key parts such as badminton racket frames and badminton racket rods and has wide application prospects. The method has wide application prospects in the fields of aerospace, intelligent structures and the like.

The invention relates to a composition which can be fixed by actinic radiation and cured by heat, the composition comprising: (A) an at least bifunctional, passivated, and solid isocyanate; (B) an isocyanate-reactive component which comprises at least one liquid hybrid compound (B1) which, in addition to at least one isocyanate-reactive group, contains at least one radically curable group, the hybrid compound (B1) having a molar mass of at least 400 g / mol; and (C) an initiator system for radical polymerisation, which comprises a first initiator (C1) and a second initiator (C2), the first initiator (C1) being a radical photoinitiator and the second initiator (C2) being a radical initiator for heat curing. The invention also relates to a method for bonding, casting and / or coating substrates, and to a use of a curable composition.

The present invention belongs to the field of materials / photoresists and relates to an "isotropic" zinc-based hybrid compound, a preparation method thereof, and an application in photoresists, so as to solve the problem of decreased film-forming properties of zinc-based hybrid compounds with a single structure in the prepared photoresist. The compound is prepared in one step using p-bromobenzoic acid and zinc acetate dihydrate as raw materials, has a molecular formula of C9H9BrO5Zn, belongs to the orthorhombic system, has a space group of Pna21, and has a unit cell length, width, and height of 8.0560(7)Å, 5.7165(6)Å, and 25.226(2)Å, respectively; α=β=γ=90°. The compound can be directly used as the sole component and mixed with an organic solvent to prepare an "isotropic" zinc-based hybrid photoresist film, and the photoresist film can be used in the field of membrane science or photolithography. The compound has good stability, and the photoresist film has good solubility, film-forming properties, adhesion, thermal stability, is easy to store, and has a stable structure.

The invention discloses high-frequency low-dielectric-constant low-loss sealing glass powder for a radio frequency device and a preparation method of the high-frequency low-dielectric-constant low-loss sealing glass powder, and belongs to the technical field of inorganic non-metallic materials. The glass powder is prepared by taking a borosilicate system as a basis and introducing two novel modifiers, namely a zinc tantalum borate complex compound and a benzoxazole cage type silsesquioxane hybrid compound; and the dielectric property under high frequency is obviously improved. The preparation process comprises the following steps: mixing, grinding and drying a basic raw material and a zinc tantalum borate compound, carrying out high-temperature smelting, applying specific frequency oscillation to obtain uniform glass liquid, carrying out double-roller cooling to prepare a glass sheet, carrying out crushing and graded ball milling, doping a benzoxazole cage-type silsesquioxane hybrid compound into final slurry, and carrying out high-temperature sintering to obtain the benzoxazole cage-type silsesquioxane / zinc tantalum borate hybrid glass. And finally, spray-drying and granulating to obtain a finished product. The obtained product has the characteristics of stable low dielectric constant and low loss in a millimeter wave frequency band, good thermal expansion coefficient matching and excellent sealing performance, and is suitable for packaging high-frequency radio frequency devices in a fifth-generation mobile communication system.

The invention discloses a polyketone-tropolone hybrid compound as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The structural formula of the polyketone-tropolone hybrid compound provided by the invention is as shown in the formula (I). The half inhibitory concentration (IC50) of the compound to human chronic myelogenous leukemia cells (K562) and human colorectal adenocarcinoma cells (HT-29) reaches a nanomole level in in-vitro antitumor activity evaluation; while the efficient anti-tumor activity is maintained, the compound has excellent tumor cell selectivity, and valuable candidate molecules are provided for research and development of novel anti-tumor drugs.

The application provides a phenazine resonance hybrid-based aqueous flow battery energy storage material, in particular, the application provides a phenazine resonance hybrid compound capable of being used as an aqueous flow battery energy storage material. The compound is simple to prepare, and the prepared battery energy storage material has good cycle stability and energy efficiency, and is suitable for being used as an aqueous flow battery energy storage material.

The invention relates to the technical field of concrete additives, in particular to a concrete anti-freezing water reducing agent and a preparation method and application thereof. The concrete anti-freezing water reducing agent comprises a compound A, a component B, a component C and a solvent D, wherein the component B comprises at least one organic acid; the component C comprises at least one fiber; the solvent D is a mixture of water and an organic solvent, and the compound A is selected from a compound represented by the following structural formula I; the concrete water reducing agent with good anti-freezing capability is prepared by the preparation method disclosed by the invention.

The present application relates to a kind of based on thin layer chromatography compound high-throughput screening and activity detection method.The screening method of the present application includes the following operating steps: 1. according to the way of first by row combination, then by column combination, mix part of compound in compound library;2. recover the lead compound;3. trace back the position of "lead compound".The present application also provides a method for verifying the influence of lead compound on the enzyme activity reaction process of protease based on thin layer chromatography, and a method for verifying the influence of lead compound on the binding of protein and small molecule substrate or polypeptide based on thin layer chromatography.The method of the present application has the characteristics of high efficiency, low cost, low technical threshold of experimental operation.

Provided is a novel composition, in particular, a composition comprising an inorganic-organic hybrid compound. The composition comprises an inorganic-organic hybrid compound and a hydrophobic resin, wherein the inorganic-organic hybrid compound comprises a polyvinyl alcohol-based resin to which a metal oxide is chemically bonded.