4 results about "False Negative Result" patented technology

The present application relates to the technical field of gene detection, in particular to a primer probe combination for detecting Alzheimer's disease, a product and application thereof. The primer probe combination and kit provided by the present application can simultaneously detect Alzheimer's disease gene mutation and methylation, can effectively distinguish Alzheimer's disease patients from non-Alzheimer's disease subjects, realize low-invasive, low-cost, high-sensitivity, high-specificity detection of Alzheimer's disease, the total sensitivity of the blood sample for detecting Alzheimer's disease can reach 88.89%, the specificity of the blood sample for detecting non-Alzheimer's disease can reach 95.74%, the detection probability of false negative results can be reduced, and the detection accuracy is high.

This invention relates to the field of gene detection technology, and in particular to a primer-probe combination, product, and application for detecting Alzheimer's disease. The primer-probe combination and kit provided by this invention can simultaneously detect Alzheimer's gene mutations and methylation, effectively distinguishing between Alzheimer's patients and non-Alzheimer's subjects. It achieves low-invasiveness, low cost, high sensitivity, and high specificity in Alzheimer's disease detection. The overall sensitivity for detecting Alzheimer's blood samples reaches 88.89%, and the specificity for detecting non-Alzheimer's blood samples reaches 95.74%, reducing the probability of false negatives and demonstrating high accuracy.

The utility model belongs to the technical field of biomedical detection, and discloses a rapid detection kit for gastric cancer nerve invasion, which comprises a cover plate hinged to the top of a kit body, and a sampling tube placing rack is embedded in the top of the kit body. Three first placing cavities, three second placing cavities and a third placing cavity are formed in the top of the kit body, a plurality of placing grooves are formed in the top of the sampling tube placing frame, collecting tubes are arranged in the placing grooves, each collecting tube comprises a first dropper fixedly connected to the center of the bottom of a tube body, and a second dropper fixedly connected to the center of the bottom of the tube body. The top of the tube body is in threaded connection with a tube cover, and a first cavity is formed in the first dropper. Complex equipment and operation steps are not needed, clinical application is facilitated, the time from sample collection to result output is greatly shortened, markers with extremely low concentration can be detected, the detection rate of early gastric cancer nerve invasion is increased, false positive and false negative results are reduced, and the detection accuracy is improved.

This invention relates to the field of detection kit technology, specifically to an African swine fever virus pathogen detection kit and detection method. This invention provides an African swine fever virus detection kit and detection method integrating specific primers and probes, a multiplex quality control system, and standardized operating procedures. By optimizing the nucleic acid extraction process, establishing a dual-channel fluorescent PCR detection system, and defining clear judgment criteria, it achieves high sensitivity and high specificity detection of African swine fever virus nucleic acid and full-process quality monitoring. It can not only accurately identify virus-positive samples but also effectively exclude false negative results through an internal standard system. This solves the key problems of insufficient specificity and low reliability of traditional detection methods, providing a stable and reliable complete technical solution for the clinical diagnosis and prevention and control of African swine fever.