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4 results about "Polyadenylation" patented technology
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Polyadenylation is the addition of a poly(A) tail to a messenger RNA. The poly(A) tail consists of multiple adenosine monophosphates; in other words, it is a stretch of RNA that has only adenine bases. In eukaryotes, polyadenylation is part of the process that produces mature messenger RNA (mRNA) for translation. It, therefore, forms part of the larger process of gene expression.
Improved recombinant polyadenylated signal sequences and their use
Owner:F HOFFMANN LA ROCHE & CO AG
Antisense oligonucleotides targeting downstream of the transcripts 3' terminus
PCT designated stageWO2026132147A1Organic active ingredientsDNA/RNA fragmentationPolyadenylationGenetics
The present invention describes that a pre-mRNA molecule, which temporarily exists before polyadenylation-site induced cleavage occurs, can be targeted by RNase H recruiting antisense oligonucleotides downstream of a transcripts 3' terminus to reduce expression levels of target genes from which the RNA polymerization originates.
Owner:F HOFFMANN LA ROCHE & CO AG +1
Single cell 3'end transcriptome variable poly-adenosine acidification analysis method
PendingCN122081469Aaccurate captureImprove detection accuracyMicrobiological testing/measurementSequence analysisPolyadenylationTranscriptome Sequencing
The invention discloses a single cell 3'end transcriptome variable polyadenylation (APA) analysis method, and belongs to the field of bioinformatics. The analysis process provided by the invention is based on 3'end transcriptome sequencing data of a single cell, combines multiple processes of UMI deduplication, false comparison removal, site merging, internal amplification removal, polyA site removal with few supporting cells, site verification and the like, and can realize efficient detection and quantification of APA at the single cell level. The method is especially suitable for single cell APA analysis of single cell 3'end transcriptome sequencing data, including 3 'end single cell sequencing data after 10x scRNA-Seq cell subset combination, 3' end single cell sequencing data based on a C1 chip, and even full-length transcriptome data.
Owner:HENAN CANCER HOSPITAL
Targeted nuclear RNA splitting and polyadenylation with CRISPR-Cas
Owner:UNIVERSITY OF ROCHESTER