409 results about "Signal region" patented technology

The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.

Chimeric gene for conferring to plants an increased tolerance to a herbicide having as its target EPSPS comprises, in the direction of transcription, a promoter region, a transit peptide region, a coding sequence for glyphosate tolerance and a polyandenylation signal region, wherein the transit peptide region comprises, in the direction of translation, at least one transit peptide of a plant gene encoding a plastid-localized enzyme and then a second transit peptide of a plant gene encoding, a plastid-localized enzyme. Production of glyphosate-tolerant plants is disclosed.

A display device and a driving method thereof includes categorizing red-color, green-color, and blue-color image signals as belonging to one of first and second signal regions, detecting if the image signals have more signals belonging to the first signal region than the second signal region or if the image signals have more signals belonging to the second signal region than the first signal region, driving an image display portion in a first manner if the image signals are detected to have more signals belonging to the first signal region than the second signal region, and driving the image display portion in a second manner if the image signals are detected to have more signals belonging to the second signal region than the first signal region, the image display portion including a plurality of pixels, each of the pixels having red-color, green-color, blue-color, and white-color sub-pixels.

An antenna arrangement for identifying an identification element in communication with an object located in an enclosure having a “null” signal region. The antenna arrangement includes a primary antenna loop element positioned in operable communication with the enclosure and the identification element positioned within the enclosure. The primary antenna loop element communicates with the identification element and receives a signal from the identification element, thereby tracking the object associated therewith. A feed point mechanism communicates with the antenna loop element and energizes the antenna loop element, transmits signals and/or receives signals. The arrangement includes a subsequent antenna element in communication with the enclosure and the identification element positioned within the enclosure, and the subsequent antenna element substantially eliminates the signal “null” region, such that at least one of the primary loop element and the subsequent antenna element can communicate with the identification element.

The present invention provides compositions and methods for treating cancer in a patient. In one embodiment, the method comprises a first-line therapy comprising administering to a patient in need thereof a genetically modified T cell expressing a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain and monitoring the levels of cytokines in the patient post T cell infusion to determine the type of second-line of therapy appropriate for treating the patient as a consequence of the presence of the CAR T cell in the patient.

The invention relates to the technical field of ultrasonic probes, in particular to an ultrasonic array probe signal acquisition component and a preparation method thereof, and a probe. The acquisition component provided by the invention comprises two or more probe array elements, each probe array element comprises a backing and a piezoelectric layer composed of two or more piezoelectric crystal plates; flangings of positive electrodes and negative electrodes of the two piezoelectric crystal plates are butted; the piezoelectric layer is divided into a lead region, a heat conduction region and a signal region; a backing is connected to the signal region, and the bottom of the backing is connected with the bottom of the backing of an adjacent probe array element; a heat dissipating piece is connected to the heat conduction region, and the heat dissipating piece is connected with the ground electrode of an outer cable; and a flexible circuit board is connected with the lead region, and the flexible circuit board is connected with the outer cable through the probe circuit board. According to the ultrasonic array probe signal acquisition component and the probe provided by invention, the problem of probe temperature rising is effectively solved, the send-receive capacity of signals is improved, probe functions of testing image resolution ratio and sharpness are improved, and the impact of the probe array element signal crosstalk to imaging sharpness is decreased.

There is provided a digital switching amplifier capable of enhancing an S/N ratio at the time of a small signal output and reducing current consumption and electromagnetic interference (EMI). The digital switching amplifier according to the present invention is provided with an integrator 11 for integrating an input signal, quantizer 12 for quantizing the output signal of the integrator 11 with resolutions different for each of the predetermined signal regions, pulse width modulator 13 for performing pulse width modulation for each of signals quantized with different resolutions by the quantizer 12 using different proportionality coefficients, switching circuit 14 for providing the load 15 with electrical signals different in value for each of pulse-width modulated signals with different proportionality coefficients by the pulse width modulator 13 in response to the pulse-width modulated signal, and feedback circuit 17 for negatively feeding back the output of the quantizer 12 to the input of the integrator 11.

A solid-state imaging device includes unit cells, arranged in a matrix of rows and columns, each having a photodiode for photoelectrically converting incident light to store signal charges, a readout transistor Td for reading out the signal charges and amplifying transistor Tb for amplifying signals readout at a detection node, a plurality of vertical shift registers for generating signal charge readout pulses ESi, DRi, ROi and a voltage switching circuit for setting a voltage VDR of the readout pulse DRi for dynamic range control lower than voltages of both a readout pulse ESi for an electronic shutter and a usual readout pulse ROi. The solid-state imaging device provides excellent images without clipping from a small signal region to large signal region.

A magnetic resonance imaging apparatus 20 includes a scan executing unit that executes scan to generate sensitivity map data of an RF coil 24, a region reduction unit 44b that applies region reduction to a signal region near a no-signal region of image data obtained by the scan, a sensitivity map data generating unit 44 that generates sensitivity map data using image data after the region reduction, and a smoothing processing unit 44i that applies three-dimensional smoothing filter to the sensitivity map data.

The invention discloses a PHS mobile phone which comprises an antenna, a front end filter, an antenna switch, a radio frequency power amplifier, a radio frequency transceiver chip, a baseband chip, a memory and a peripheral device. The antenna, the front end filter, the antenna switch, the radio frequency power amplifier, the radio frequency transceiver chip and the baseband chip are connected in turn, and the baseband chip is further connected with the memory and the peripheral device respectively. The invention further discloses a transmission power control method of the PHS mobile phone. The PHS mobile phone can adjust the transmission power of the PHS mobile phone at all times according to the strength range of received signals. The transmission power of the PHS mobile phone is increased in the weak signal area, and the transmission power of the PHS mobile phone is reduced in the stronger signal area.

The invention relates to a chimeric antigen acceptor of a target BCMA (B cell maturation antigen). The chimeric antigen acceptor comprises an extracellular identification region, a hinge region, a transmembrane region and an intracellular signal region, wherein the extracellular identification region has a BCMA resisting nanometer antibody sequence, and the BCMA resisting nanometer antibody sequence is a heavy-chain variable region sequence combining with BCMA and from alpacas. More specifically, the BCMA resisting nanometer antibody sequence is BCMA monoclonal antibody B1 or B65, the amino acid sequence of the B1 is as shown in SEQID NO.1, and the amino acid sequence of the B65 is as shown in SEQID NO.2. According to the chimeric antigen acceptor disclosed by the invention, compared witha traditional mouse-derived SCFV or humanized SCFV, the nanometer antibody from the alpacas is used, and has small molecule quantity and immunogenicity, the possibility that CAR-T cells prepared on the base of the nanometer antibody produce HAMA effects in vivo is smaller, the remaining time of the CAR-T cells in vivo can be longer, the CAR-T cells pass through BCMA protein on the surfaces of target tumor cells and activate signal channels at the downstream part of T cells, the capacity for killing tumor cells having BCMA target points is given to the T cells, and BCMA positive blood tumor canbe efficiently and specifically treated.

The invention belongs to the field of genetic engineering and particularly relates to an anti-CD123 single-chain antibody, a chimeric antigen receptor combined by the same, and application thereof. The anti-CD123 single-chain antibody is a CD123 antigen-recognizing peptide with an amino acid sequence shown as SEQ ID NO: 1. The anti-CD123 antigen chimeric antigen receptor is formed by sequentiallyconnecting the CD123 antigen-recognizing peptide (ScFv), a hinge region, a transmembrane region and an intracellular signal region. When being expressed in immune cells, the anti-CD123 antigen chimeric antigen receptor can not only effectively eliminate target tumor cells, which can express CD123 antigens, without toxicity to tumor cell with negative antigens/incapable of expressing CD123, but also maintain the positive rate of a CD123-targeted antigen chimeric antigen receptor (CAR) during patient cell culturing, which can propagate for a long time after being stimulated by target antigens and accordingly achieves targeted treatment on tumors.

A BGA semiconductor device for high-speed operation and high pin counts has a base which is constituted by a core layer formed of wiring boards and surface layers provided on both sides of the core layer, and a semiconductor element mounted on the base. Through holes in a signal region of the core layer are disposed in an optimum through hole pattern in which power through holes and ground through holes are disposed adjacent to signal through holes.

Apparatus for detecting vibration of an object adapted to rotate includes one or more vibration processors selected from: a direction-change processor adapted to detect changes in a direction of rotation of the object, a direction-agreement processor adapted to identify a direction of rotation of the object in at least two channels and identify an agreement or disagreement in direction of rotation identified by the at least two channels, a phase-overlap processor adapted to identify overlapping signal regions in signals associated with the rotation of the object, and a running mode processor adapted to identify an unresponsive output signal from at least one of the at least two channels. A method for detecting the vibration of the object includes generating at least one of a direction-change output signal with the direction-change processor, a direction-agreement output signal with the direction-agreement processor, a phase-overlap output signal with the phase-overlap processor, and a running-mode-vibration output signal with the running-mode processor, each indicative of the vibration the object.