423 results about "Signal region" patented technology

The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.

Chimeric gene for conferring to plants an increased tolerance to a herbicide having as its target EPSPS comprises, in the direction of transcription, a promoter region, a transit peptide region, a coding sequence for glyphosate tolerance and a polyandenylation signal region, wherein the transit peptide region comprises, in the direction of translation, at least one transit peptide of a plant gene encoding a plastid-localized enzyme and then a second transit peptide of a plant gene encoding, a plastid-localized enzyme. Production of glyphosate-tolerant plants is disclosed.

Chimeric T cell receptors (TCR) are provided that combine, in a single chimeric species, the intracellular domain of CD3 zeta-chain, a signaling region from a costimulatory protein such as CD28, and a binding element that specifically interacts with a selected target. When expressed, for example in T-lymphocytes from the individual to be treated for a condition associated with the selected target, a T cell immune response is stimulated in the individual to the target cells. The chimeric TCR's are able to provide both the activation and the co-stimulation signals from a single molecule to more effectively direct T-lymphocyte cytotoxicity against the selected target and T-lymphocyte proliferation.

The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell to express a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.

Ingress noise from subscriber equipment is mitigated or prevented from reaching a cable television (CATV) network. All upstream signals including ingress noise are initially transmitted to the CATV network whenever their instantaneous power exceeds a threshold which typically distinguishes ingress noise from a valid upstream signal. Whenever the instantaneous power is below the threshold, ingress noise is blocked from reaching the CATV network. A gas tube surge protection device is included to resist component destruction and malfunction arising from lightning strikes and other high voltage, high current surges.

The present invention provides compositions and methods for inducing tolerance in a human. The invention includes administering a genetically modified T cell expressing a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain.

Apparatus for detecting vibration of an object adapted to rotate includes one or more vibration processors selected from: a direction-change processor adapted to detect changes in a direction of rotation of the object, a direction-agreement processor adapted to identify a direction of rotation of the object in at least two channels and identify an agreement or disagreement in direction of rotation identified by the at least two channels, and a phase-overlap processor adapted to identify overlapping signal regions in signals associated with the rotation of the object. A method for detecting the vibration of the object includes generating at least one of a direction-change output signal with the direction-change processor, generating a direction-agreement output signal with the direction-agreement processor, and generating a phase-overlap output signal with the phase-overlap processor, each indicative of the vibration of the object.

A display device and a driving method thereof includes categorizing red-color, green-color, and blue-color image signals as belonging to one of first and second signal regions, detecting if the image signals have more signals belonging to the first signal region than the second signal region or if the image signals have more signals belonging to the second signal region than the first signal region, driving an image display portion in a first manner if the image signals are detected to have more signals belonging to the first signal region than the second signal region, and driving the image display portion in a second manner if the image signals are detected to have more signals belonging to the second signal region than the first signal region, the image display portion including a plurality of pixels, each of the pixels having red-color, green-color, blue-color, and white-color sub-pixels.

An antenna arrangement for identifying an identification element in communication with an object located in an enclosure having a “null” signal region. The antenna arrangement includes a primary antenna loop element positioned in operable communication with the enclosure and the identification element positioned within the enclosure. The primary antenna loop element communicates with the identification element and receives a signal from the identification element, thereby tracking the object associated therewith. A feed point mechanism communicates with the antenna loop element and energizes the antenna loop element, transmits signals and / or receives signals. The arrangement includes a subsequent antenna element in communication with the enclosure and the identification element positioned within the enclosure, and the subsequent antenna element substantially eliminates the signal “null” region, such that at least one of the primary loop element and the subsequent antenna element can communicate with the identification element.

In one aspect, apparatus and method are provided for communicating data in the form of transmission symbols conveyed in a carrier signal, wherein each transmission symbol is from a symbol set comprising a plurality of symbols which are collectively capable of representing any combination of values for at least three bits of data, wherein each symbol of the symbol set is defined with at most one transition of signal level in the carrier signal. In another aspect, apparatus and method are provided for communicating any combination of values for at least three data bits in the form of a respective transmission symbol conveyed in a carrier signal, wherein the transmission symbol is uniquely defined by a respective combination of a signal level transition, a lack of signal level transition, a signal region, and a cross-over between signal regions in the carrier signal.

The present invention provides compositions and methods for treating cancer in a patient. In one embodiment, the method comprises a first-line therapy comprising administering to a patient in need thereof a genetically modified T cell expressing a CAR wherein the CAR comprises an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain and monitoring the levels of cytokines in the patient post T cell infusion to determine the type of second-line of therapy appropriate for treating the patient as a consequence of the presence of the CAR T cell in the patient.

The invention relates to the technical field of ultrasonic probes, in particular to an ultrasonic array probe signal acquisition component and a preparation method thereof, and a probe. The acquisition component provided by the invention comprises two or more probe array elements, each probe array element comprises a backing and a piezoelectric layer composed of two or more piezoelectric crystal plates; flangings of positive electrodes and negative electrodes of the two piezoelectric crystal plates are butted; the piezoelectric layer is divided into a lead region, a heat conduction region and a signal region; a backing is connected to the signal region, and the bottom of the backing is connected with the bottom of the backing of an adjacent probe array element; a heat dissipating piece is connected to the heat conduction region, and the heat dissipating piece is connected with the ground electrode of an outer cable; and a flexible circuit board is connected with the lead region, and the flexible circuit board is connected with the outer cable through the probe circuit board. According to the ultrasonic array probe signal acquisition component and the probe provided by invention, the problem of probe temperature rising is effectively solved, the send-receive capacity of signals is improved, probe functions of testing image resolution ratio and sharpness are improved, and the impact of the probe array element signal crosstalk to imaging sharpness is decreased.

There is provided a digital switching amplifier capable of enhancing an S / N ratio at the time of a small signal output and reducing current consumption and electromagnetic interference (EMI). The digital switching amplifier according to the present invention is provided with an integrator 11 for integrating an input signal, quantizer 12 for quantizing the output signal of the integrator 11 with resolutions different for each of the predetermined signal regions, pulse width modulator 13 for performing pulse width modulation for each of signals quantized with different resolutions by the quantizer 12 using different proportionality coefficients, switching circuit 14 for providing the load 15 with electrical signals different in value for each of pulse-width modulated signals with different proportionality coefficients by the pulse width modulator 13 in response to the pulse-width modulated signal, and feedback circuit 17 for negatively feeding back the output of the quantizer 12 to the input of the integrator 11.

A solid-state imaging device includes unit cells, arranged in a matrix of rows and columns, each having a photodiode for photoelectrically converting incident light to store signal charges, a readout transistor Td for reading out the signal charges and amplifying transistor Tb for amplifying signals readout at a detection node, a plurality of vertical shift registers for generating signal charge readout pulses ESi, DRi, ROi and a voltage switching circuit for setting a voltage VDR of the readout pulse DRi for dynamic range control lower than voltages of both a readout pulse ESi for an electronic shutter and a usual readout pulse ROi. The solid-state imaging device provides excellent images without clipping from a small signal region to large signal region.

A magnetic resonance imaging apparatus 20 includes a scan executing unit that executes scan to generate sensitivity map data of an RF coil 24, a region reduction unit 44b that applies region reduction to a signal region near a no-signal region of image data obtained by the scan, a sensitivity map data generating unit 44 that generates sensitivity map data using image data after the region reduction, and a smoothing processing unit 44i that applies three-dimensional smoothing filter to the sensitivity map data.

The invention discloses a PHS mobile phone which comprises an antenna, a front end filter, an antenna switch, a radio frequency power amplifier, a radio frequency transceiver chip, a baseband chip, a memory and a peripheral device. The antenna, the front end filter, the antenna switch, the radio frequency power amplifier, the radio frequency transceiver chip and the baseband chip are connected in turn, and the baseband chip is further connected with the memory and the peripheral device respectively. The invention further discloses a transmission power control method of the PHS mobile phone. The PHS mobile phone can adjust the transmission power of the PHS mobile phone at all times according to the strength range of received signals. The transmission power of the PHS mobile phone is increased in the weak signal area, and the transmission power of the PHS mobile phone is reduced in the stronger signal area.

A transmitting apparatus includes a frame generator configured to map data included in an input stream to at least one signal processing path to generate a frame, an information inserter configured to insert signaling information to a signaling region of the frame, and a transmitter configured to transmit the frame with the signaling information inserted therein. The signaling information including input stream synchronizer (ISSY) mode information, receiver buffer size information required according to the ISSY mode information, and time information representing a time between a P1 symbol of a preset frame for transmitting a user packet and an output of a preset bit of a first user packet of the user packet.

A first white balance correction value is computed by detecting white pixels from an image. A determination is made as to whether or not a corrected image signal in the face region falls into a second color signal region surrounding a first color signal region that represents a skin color if white balance of the image signal in the face region is corrected based on the first white balance correction value. When it is determined that the corrected image signal of the face region falls into the second color signal region, a second white balance correction value for correcting the image signal is computed based on relationships between the corrected image signal of face region and the first color signal region. The computed second white balance correction value is modified based on information obtained when the image was captured.

A method, medium, and system for masking voice information of a communication device. The method of masking a user's voice through an output of a masking signal similar to a formant of voice data may include dividing the voice data received into frames of a predetermined size, transforming the frames on a frequency axis thereof, regarded as a domain, obtaining formant information of intensive signal regions in the transformed frames, generating a sound signal disturbing the formant information with reference to the formant information, and outputting the sound signal in accordance with a time point when the voice signal is output.

Signals of interest in magnetic resonance imaging (MRI) systems comprise narrowband, circularly polarized (CP) radio-frequency magnetic fields from rotating atomic nuclei. Background “body noise” may comprise broadband, linearly polarized (LP) magnetic fields from thermally-activated eddy currents, and may exceed the signal in a band of interest, limiting the imaging resolution and requiring excessive averaging times. Noise may be selectively detected and substantially suppressed, while enhancing the signal of interest, using appropriate digital time-domain algorithms. At least two quadrature receiving antennas may be employed to distinguish and separate the LP noise from the CP signal. At least one broadband receiver may be used to identify and localize fast noise sources and to digitally filter the representation of their radio-frequency magnetic fields in the signal. Selective body noise reduction may allow enhanced signal-to-noise ratio of the system, leading to improved imaging resolution and shorter scan time.

The method for forming high-resolution ratio spliced TV curtain includes: A resolution ratio RGB signal is conducted video processing by a computer, then is conducted division processing through a PCI multi-screen splicing insertion-card to divide RGB signal into m sub signals of lower resolution ratio; Each sub signal is accessed with a distributor and processed by the distributor, then distributes n branch signals accordant with the sub signal; Each of the n branch signals respectively is accessed in a display unit; Each display unit displays the amplified image of corresponding signal region according its position in the TV curtain. The combined display of display units realizes the display of high-resolution ratio RGB signals.

The invention relates to a chimeric antigen acceptor of a target BCMA (B cell maturation antigen). The chimeric antigen acceptor comprises an extracellular identification region, a hinge region, a transmembrane region and an intracellular signal region, wherein the extracellular identification region has a BCMA resisting nanometer antibody sequence, and the BCMA resisting nanometer antibody sequence is a heavy-chain variable region sequence combining with BCMA and from alpacas. More specifically, the BCMA resisting nanometer antibody sequence is BCMA monoclonal antibody B1 or B65, the amino acid sequence of the B1 is as shown in SEQID NO.1, and the amino acid sequence of the B65 is as shown in SEQID NO.2. According to the chimeric antigen acceptor disclosed by the invention, compared witha traditional mouse-derived SCFV or humanized SCFV, the nanometer antibody from the alpacas is used, and has small molecule quantity and immunogenicity, the possibility that CAR-T cells prepared on the base of the nanometer antibody produce HAMA effects in vivo is smaller, the remaining time of the CAR-T cells in vivo can be longer, the CAR-T cells pass through BCMA protein on the surfaces of target tumor cells and activate signal channels at the downstream part of T cells, the capacity for killing tumor cells having BCMA target points is given to the T cells, and BCMA positive blood tumor canbe efficiently and specifically treated.

A CPU performs a control for photographing a main subject in absence of auxiliary light, whereby an image signal is outputted from an analogue signal processing section. Next, the CPU performs a control for photographing the main subject in presence of the auxiliary light, whereby an image signal is outputted from the analogue signal processing section. An AF area extracting section extracts image signals in an AF area from the image signals. A differential signal calculating section outputs a differential signal between the extracted image signal, and a distance measuring section compares magnitudes of that differential signal and a reference value in a distance data base to calculate distance information based on the comparison result. An AF control section executes AF control of mountain climbing system with the use of the distance information.