3451results about "Analysis using nuclear magnetic resonance" patented technology

This invention provides method and system for measuring changes in the brain activity of an individual by functional brain imaging methods for investigative purposes, e.g., detecting and assessing whether an individual is being truthful or deceptive, and / or whether an individual has a prior knowledge of a certain face or object. The invention combines recent progress in medical brain imaging, computing and neuroscience to produce an accurate and objective method of detection of deception and concealed prior knowledge based on an automated analysis of the direct measurements of brain activity. Applying the paradigm developed from the deception model, and applying it to an individual viewing media information (e.g., audiovisual messages or movies, or announcements), the data is used to interpret the effect of the information on that individual. This permits the effective manipulation of the content of the media segments to achieve maximal desired impact in target populations or on specific individuals.

This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and / or disaggregation of the nanoparticles caused by the presence and / or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response.

An apparatus and a method is provided based on the Magnetic Resonance techniques to analyze and measure a uni- and / or a bi-directional flow regime of multiphase fluids in a transport and production conduct, in real time and flow-rates, based on a magnetic resonance analytical module, two magnetic prepolarization modules of variable effective length and a control computer of data acquisition and transfer, all associated to each other.

An inspection system includes a passenger identity verification system, a passenger screening system, and a computer coupled to the passenger verification system and the passenger screening system, the computer configured to receive information from the passenger verification system and operate the passenger screening system based on the information.

This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point of care diagnosis and / or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient.

Methods for assessing the risk of developing Type 2 diabetes and other related disorders include obtaining an NMR derived reference spectrum for a known glucose concentration sample and storing this information as a reference standard. A patient blood sample is collected and NMR derived patient spectrums for the blood sample are obtained. The two NMR data sets (the reference and the patient) are compared and a glucose concentration is determined for the patient sample. The glucose concentration can be evaluated with a blood sample undergoing lipoprotein cholesterol evaluation. The NMR based test can be used to concurrently provide a glucose concentration and lipoprotein constituent values based on a single testing event. The disclosure also includes a multi-purpose test, i.e., a test which concurrently provides lipoprotein screening and coronary heart disease risk evaluation along with a diabetes screening and risk assessment for developing Type 2 diabetes. A method for assessing diabetes includes identifying the presence of diabetic dyslipidemia based on the values of predetermined NMR measured lipoprotein constituents.

The present invention relates to a method for the assessment of quantity and quality parameters of biological particles in a liquid analyte material. The method comprises applying a volume of a liquid sample to an exposing domain from which exposing domain electromagnetic signals from the sample in the domain can pass to the exterior, and exposing, onto an array of active detection elements such as CCD-elements, a spatial representation of electromagnetic signals having passed from the domain, the representation being detectable as an intensity by individual active detection elements, under conditions permitting processing of the intensities detected by the array of detection elements during the exposure in such a manner that representations of electromagnetic signals from the biological particles are identified as distinct from representations of electromagnetic signals from background signals. The size of the volume of the liquid sample is sufficiently large to permit the assessment of the quantity and quality parameters to fulfill a predetermined requirement to the statistical quality of the assessment based on substantially one exposure.

A method for differentiating complex mixtures each having one or more chemical species is provided. The method comprises producing a sample NMR spectrum by subjecting a mixture to a selective spectroscopy process, wherein the NMR spectrum has individual spectral peaks representative of the one or more chemical species within the mixture. The one or more chemical species within the mixture are identified by analyzing the individual spectral peaks, and the individual spectral peaks are then subjected to a multivariate statistical analysis.

The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body, said method comprising the step of ex vivo polarisation of a high T1 agent and wherein the polarising agent is optionally seperated from the high T1 agent before the high T1 agent is administered to the sample.

This invention relates generally to detection devices having one or more small wells each surrounded by, or in close proximity to, an NMR micro coil, each well containing a liquid sample with magnetic nanoparticles that self-assemble or disperse in the presence of a target analyte, thereby altering the measured NMR properties of the liquid sample. The device may be used, for example, as a portable unit for point of care diagnosis and / or field use, or the device may be implanted for continuous or intermittent monitoring of one or more biological species of interest in a patient.

A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is / are present in the fluid.

An n-NV-based gyroscope is provided that includes a diamond structure implanted with a plurality of NV centers, whose nuclear spins form a spin gyroscope. A number of radio-frequency (rf) coils and microwave (μw) co-planar waveguides are fabricated on the diamond structure to provide a sensitive and stable three-axis gyroscope in the solid state while achieving gyroscopic sensitivity by exploiting the coherence time of the 14N nuclear spin associated with the NV centers in the diamond structure combined with the efficient optical polarization and measurement of electronic spin.

A carbon dioxide drive nuclear magnetic resonance imaging detection device belongs to the technical field of petroleum engineering and technology. The detection device comprises: a simulation core device which is arranged in a nuclear magnetic resonance imaging device; an injection system which sequentially injects formation water, crude oil and supercritical carbon oxide into the simulation core device; a measurement and control system which is employed to control pressure and temperature of the whole system; the nuclear magnetic resonance imaging device which is employed to detect and perform quantitative analysis on an image to be tested to obtain voidage and permeability of a porous medium, and saturation seepage parameters of the supercritical carbon oxide, the formation water and the crude oil; and an output measuring system which is employed to measure volumes of the carbon dioxide gas, the formation water and the crude oil. The detection device has a design pressure of 0-40MPa and design temperature of 0-180 DEG C, and can simulate experimental studies of different displacement schemes of the supercritical CO2 under a complex petroleum reservoir condition; the simulation core device is made of a brass material, which produces no magnetism, satisfies requirements for high pressure and strength, has a compact structure, can be recycled, is conveniently operated, simple and applicable in an experimentation.

The invention discloses a high-resolution digital rock core modeling method. The high-resolution digital rock core modeling method comprises the following steps: firstly, scanning a rock core by X-ray CT (computed tomography); then acquiring the rock throat radius distribution from rock core mercury data, acquiring the rock core porosity radius distribution from rock core nuclear magnetism data, intercepting the part the pore throat radius of which is less than the CT scanning resolution as an input parameter of a random network method, wherein the selected intercepted value is relevant to the CT scanning resolution; comparing the digital rock core porosity obtained by CT scanning with the experiment measurement porosity, calculating the size of the lost porosity of the digital rock core by CT scanning, and constructing a porosity network model by utilizing the intercepted pore throat radius distribution by adopting the random network method, wherein the porosity of the generated network model is consistent with the porosity lost in CT scanning; and converting the porosity network model into the micro porosity digital rock core by applying gridding method, and overlapping the digital rock core constructed by a mercury injection nuclear magnetism method to the digital rock core scanned by CT by adopting a multi-scale integration method. The method breaks through the restriction of CT scanning resolution.

A method for determining a formation fluid property includes acquiring a suite of nuclear magnetic resonance (NMR) measurements of a fluid sample using a pulse sequence that includes pulsed field gradient pulses for encoding diffusion information, wherein each NMR measurement in the suite is acquired with a different value in a parameter in the pulsed field gradient pulses for producing a different diffusion effect, wherein the acquiring is performed in a formation fluid sampling tool in a borehole; inverting the suite of NMR measurements to produce a distribution function that relates diffusion properties of the fluid sample with an NMR property of the fluid sample; and determining the formation fluid property from the distribution function.

Methods, systems and computer programs are configured to determine the presence of and / or a measurement for a plurality of constituents in a composite signal with closely correlated chemical constituents having overlapping signal lineshapes extending about a spectrum of interest obtained from a target sample undergoing analysis.

The invention discloses an electromagnetic field near-field imaging system and method based on pulsed light detection magnetic resonance. The system consists of a laser pump optical path, a microwave source, a diamond NV color-center probe, a CCD camera unit, a synchronization system, a displacement scanning platform, control software and a data analysis imaging system. In the system, a large diamond single crystal containing the NV color-center is used as a detection unit, a static magnetic field is used to split a magnetic resonance peak of the diamond NV color-center into eight peaks, the eight resonance peaks correspond to four crystal axis directions <111>, <1-11>, <-111>, <11-1> of a diamond lattice structure, by measuring the Rabi frequency of each resonance peak, the strength of a circularly polarized microwave field perpendicular to the corresponding crystal axis direction is obtained, and through comprehensive calculation of the microwave field strengths in the four directions, the strength and direction of a microwave vector are then reconstructed. Through the microwave near-field high-resolution imaging of a local region of a microwave chip under measurement, the quantitative data can be provided for the failure analysis of the chip.

The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

The invention discloses a rock nuclear magnetic resonance relaxation signal measuring device of formation rock matter property, which comprises the following parts: magnet, probe, preposition amplifier, power amplifier, nuclear magnetic resonance controller and control computer, wherein the nuclear magnetic resonance controller generates specific frequency and waveshape radio frequency actuation impulse, which is sent to the nuclear magnetic resonance probe in the magnet after magnified; the rock sample is set in the exciting probe, which generates nuclear magnetic resonance backward wave signal; the nuclear magnetic resonance probe receives the backward wave signal and sends to the nuclear magnetic resonance controller after magnified, which is sent to the computer finally. The invention can generate the parameter for usage directly, which can be applied in the oil field nuclear magnetic resonance well.

During operation, a system may apply a polarizing field and an excitation sequence to a sample. Then, the system may measure a signal associated with the sample for a time duration that is less than a magnitude of a relaxation time associated with the sample. Next, the system may calculate the relaxation time based on a difference between the measured signal and a predicted signal of the sample, where the predicted signal is based on a forward model, the polarizing field and the excitation sequence. After modifying at least one of the polarizing field and the excitation sequence, the aforementioned operations may be repeated until a magnitude of the difference is less than a convergence criterion. Note that the calculations may be performed concurrently with the measurements and may not involve performing a Fourier transform on the measured signal.

A method for generating a magnetic resonance image is provided. A magnetic resonance imaging excitation is applied for a plurality of cycles at a cycle rate. A plurality of magnetic resonance image echoes is acquired for each cycle. A decay map is estimated from the plurality of magnetic resonance image echoes for each cycle. The estimated decay map is used to generate an image for at least two different species.

The present invention provides methods and materials useful for monitoring and regulating the glycosylation of glycoproteins that are recombinantly produced from cells. In particular, methods are provided for monitoring and regulating levels of cellular indicators which affect the level of fucosylation produced by cells.

The invention discloses a nuclear magnetic resonance analyzer and a nuclear magnetic resonance measuring method. The analyzer comprises a radio frequency circuit, a magnet, a glass tube, a first coil and a second coil, wherein a sample to be measured is placed in the glass tube; the glass tube is fixedly arranged at a position opposite to the magnet and is placed in a magnetic field produced by the magnet; the first coil and the second coil are wound on the outer surface of the glass tube respectively and are connected with the radio frequency circuit; the first coil is placed at a uniform magnetic field produced by the magnet; and the second coil is placed at a gradient magnetic field produced by the magnet. Through the analyzer, distribution data of transverse relaxation time and longitudinal relaxation time of substances in the sample to be measured can be obtained, and distribution data of diffusion coefficients of the substances in the sample can be obtained.

A method for determining a property of fluids in formations surrounding an earth borehole includes the following steps: producing, from measurements on a multiplicity of fluid samples, a database of stored fluid property training values related to stored fluid measurement training values; deriving, from the database, radial basis function parameters; deriving formation fluid measurement values; and determining, using radial basis function interpolation, the property of formation fluids from values in the database, the parameters, and the derived formation fluid measurement values.

This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and / or disaggregation of the nanoparticles caused by the presence and / or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response.

The invention provides a high-temperature high-pressure clamp for testing rock core by nuclear magnetic resonance, which is applied to rock core dynamic experiments in a laboratory. The clamp mainly comprises an annulus pressure part, a high-temperature heating part, a displace part and a nuclear magnetic resonance part, wherein a sealing end cover and a lock nut are arranged at two ends of a cavity of the clamp; an annulus pressure oil inlet pipe and an annulus pressure oil drain pipe pass through the sealing end cover and are communicated with the cavity of the clamp; a spiral heat-conducting oil pipe is arranged between an insulating shell and the cavity of the clamp; two cylindrical rock core tops and sealing members are arranged in a fluorine rubber tube; a displacing oil inlet pipe and a displacing oil outlet pipe are fixed at two ends of the cylindrical sealing members; a nuclear magnetic resonance coil frame is arranged in the cavity of the clamp; and a nuclear magnetic resonance coil is arranged in an annular space formed between the outer wall of the nuclear magnetic resonance coil frame and the cavity of the clamp. The clamp has the advantages of simulating temperature and pressure of the rock core in the stratum to ensure that a nuclear magnetic resonance instrument can measure the physical parameters of the rock core under the condition of simulating the stratum.

The present invention provides a quality control system characterized by:a. a line of substantially-solid food-products, said products at least partially enclosed in a flexible aluminum foil wrapper and randomly-orientated on said line;b. an MRI device adapted to image each of said products on said line; said MRI is in communication with a computer readable medium adapted to (i) store at least one computer-retrievable standardized parameter related with a standard product; (ii) analyze said MRI thereby providing an online parameter; (iii) compare said online parameter with said predefined standardized parameter; and thereby (iv), detect defects in said products.