1441results about "Analysis using nuclear magnetic resonance" patented technology

This invention provides method and system for measuring changes in the brain activity of an individual by functional brain imaging methods for investigative purposes, e.g., detecting and assessing whether an individual is being truthful or deceptive, and/or whether an individual has a prior knowledge of a certain face or object. The invention combines recent progress in medical brain imaging, computing and neuroscience to produce an accurate and objective method of detection of deception and concealed prior knowledge based on an automated analysis of the direct measurements of brain activity. Applying the paradigm developed from the deception model, and applying it to an individual viewing media information (e.g., audiovisual messages or movies, or announcements), the data is used to interpret the effect of the information on that individual. This permits the effective manipulation of the content of the media segments to achieve maximal desired impact in target populations or on specific individuals.

This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and/or disaggregation of the nanoparticles caused by the presence and/or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response.

An apparatus and a method is provided based on the Magnetic Resonance techniques to analyze and measure a uni- and/or a bi-directional flow regime of multiphase fluids in a transport and production conduct, in real time and flow-rates, based on a magnetic resonance analytical module, two magnetic prepolarization modules of variable effective length and a control computer of data acquisition and transfer, all associated to each other.

An inspection system includes a passenger identity verification system, a passenger screening system, and a computer coupled to the passenger verification system and the passenger screening system, the computer configured to receive information from the passenger verification system and operate the passenger screening system based on the information.

The present invention provides a method of magnetic resonance investigation of a sample, preferably of a human or non-human animal body, said method comprising the step of ex vivo polarisation of a high T1 agent and wherein the polarising agent is optionally seperated from the high T1 agent before the high T1 agent is administered to the sample.

A biological detector includes a conduit for receiving a fluid containing one or more magnetic nanoparticle-labeled, biological objects to be detected and one or more permanent magnets or electromagnet for establishing a low magnetic field in which the conduit is disposed. A microcoil is disposed proximate the conduit for energization at a frequency that permits detection by NMR spectroscopy of whether the one or more magnetically-labeled biological objects is/are present in the fluid.

A carbon dioxide drive nuclear magnetic resonance imaging detection device belongs to the technical field of petroleum engineering and technology. The detection device comprises: a simulation core device which is arranged in a nuclear magnetic resonance imaging device; an injection system which sequentially injects formation water, crude oil and supercritical carbon oxide into the simulation core device; a measurement and control system which is employed to control pressure and temperature of the whole system; the nuclear magnetic resonance imaging device which is employed to detect and perform quantitative analysis on an image to be tested to obtain voidage and permeability of a porous medium, and saturation seepage parameters of the supercritical carbon oxide, the formation water and the crude oil; and an output measuring system which is employed to measure volumes of the carbon dioxide gas, the formation water and the crude oil. The detection device has a design pressure of 0-40MPa and design temperature of 0-180 DEG C, and can simulate experimental studies of different displacement schemes of the supercritical CO2 under a complex petroleum reservoir condition; the simulation core device is made of a brass material, which produces no magnetism, satisfies requirements for high pressure and strength, has a compact structure, can be recycled, is conveniently operated, simple and applicable in an experimentation.

The invention discloses a high-resolution digital rock core modeling method. The high-resolution digital rock core modeling method comprises the following steps: firstly, scanning a rock core by X-ray CT (computed tomography); then acquiring the rock throat radius distribution from rock core mercury data, acquiring the rock core porosity radius distribution from rock core nuclear magnetism data, intercepting the part the pore throat radius of which is less than the CT scanning resolution as an input parameter of a random network method, wherein the selected intercepted value is relevant to the CT scanning resolution; comparing the digital rock core porosity obtained by CT scanning with the experiment measurement porosity, calculating the size of the lost porosity of the digital rock core by CT scanning, and constructing a porosity network model by utilizing the intercepted pore throat radius distribution by adopting the random network method, wherein the porosity of the generated network model is consistent with the porosity lost in CT scanning; and converting the porosity network model into the micro porosity digital rock core by applying gridding method, and overlapping the digital rock core constructed by a mercury injection nuclear magnetism method to the digital rock core scanned by CT by adopting a multi-scale integration method. The method breaks through the restriction of CT scanning resolution.

Methods, systems and computer programs are configured to determine the presence of and/or a measurement for a plurality of constituents in a composite signal with closely correlated chemical constituents having overlapping signal lineshapes extending about a spectrum of interest obtained from a target sample undergoing analysis.

The invention provides a bio-sensing nanodevice comprising: a stabilized G-protein coupled receptor on a support, a real time receptor-ligand binding detection method, a test composition delivery system and a test composition recognition program. The G-protein coupled receptor can be stabilized using surfactant peptide. The nanodevice provides a greater surface area for better precision and sensitivity to odorant detection. The invention further provides a microfluidic chip containing a stabilized G-protein coupled receptor immobilized on a support, and arranged in at least two dimensional microarray system. The invention also provides a method of delivering odorant comprising the step of manipulating the bubbles in complex microfluidic networks wherein the bubbles travel in a microfluidic channel carrying a variety of gas samples to a precise location on a chip. The invention further provides method of fabricating hOR17-4 olfactory receptor.

A method for generating a magnetic resonance image is provided. A magnetic resonance imaging excitation is applied for a plurality of cycles at a cycle rate. A plurality of magnetic resonance image echoes is acquired for each cycle. A decay map is estimated from the plurality of magnetic resonance image echoes for each cycle. The estimated decay map is used to generate an image for at least two different species.

The present invention provides methods and materials useful for monitoring and regulating the glycosylation of glycoproteins that are recombinantly produced from cells. In particular, methods are provided for monitoring and regulating levels of cellular indicators which affect the level of fucosylation produced by cells.

The invention discloses a nuclear magnetic resonance analyzer and a nuclear magnetic resonance measuring method. The analyzer comprises a radio frequency circuit, a magnet, a glass tube, a first coil and a second coil, wherein a sample to be measured is placed in the glass tube; the glass tube is fixedly arranged at a position opposite to the magnet and is placed in a magnetic field produced by the magnet; the first coil and the second coil are wound on the outer surface of the glass tube respectively and are connected with the radio frequency circuit; the first coil is placed at a uniform magnetic field produced by the magnet; and the second coil is placed at a gradient magnetic field produced by the magnet. Through the analyzer, distribution data of transverse relaxation time and longitudinal relaxation time of substances in the sample to be measured can be obtained, and distribution data of diffusion coefficients of the substances in the sample can be obtained.

The present invention provides a quality control system characterized by:

• • a. a line of substantially-solid food-products, said products at least partially enclosed in a flexible aluminum foil wrapper and randomly-orientated on said line;
  • b. an MRI device adapted to image each of said products on said line; said MRI is in communication with a computer readable medium adapted to (i) store at least one computer-retrievable standardized parameter related with a standard product; (ii) analyze said MRI thereby providing an online parameter; (iii) compare said online parameter with said predefined standardized parameter; and thereby (iv), detect defects in said products.

The invention discloses a method for evaluating a water-containing characteristic and an occurrence state of compact sandstone storage layer apertures, comprising: converting a nuclear magnetic T2 spectrum into a false capillary pressure curve by a rock core intrusive mercury experiment and a nuclear magnetic resonance experiment; obtaining a permeability accumulation contribution value by a rock core intrusive mercury experiment, and establishing a storage layer aperture throat space validity division standard based on the permeability accumulation contribution value; and based on the aperture throat space validity division standard, and calculating a clay bound water volume, an immovable capillary bound water volume and a movable fluid volume by the false capillary pressure curve, to implement evaluation of the water-containing characteristic and the occurrence state of the compact sandstone storage layer apertures.

A magnetic resonance imaging apparatus includes an imaging unit which applies a labeling pulse to invert a spin included in a labeling region within part of a imaging region and then collects a echo signal from a time point when an inversion time has passed from the application of the labeling pulse, and a control unit, the control unit controlling the imaging unit so that the echo signal in the imaging region is collected a plurality of times with variations in the inversion time, the control unit also controlling the imaging unit so that a time ranging from a reference time point within a biological signal obtained from a subject to the application of the labeling pulse is a time determined in accordance with the inversion time.

A method and apparatus for polarizing nuclear or electronic spins is disclosed. An analyte is passed near a surface that has a plurality of spin defect centers implanted within 10 nm of the surface. The spin defect centers are exposed to a magnetic field and illumination to produce polarized spins. The polarized spins then induce spin polarization in the analyte.

The invention discloses a shale micropore size and fluid distribution analysis method. The shale micropore size and fluid distribution analysis method comprises the following steps that shale gas reservoir rock is collected, and a natural core is manufactured; the relaxation characteristic of hydrogen-contained fluid in core pores is measured through a nuclear magnetic resonance spectrometer, and a relaxation time T2 distribution map of clay water is obtained; the core is processed to obtain a saturated core, and a relaxation time T2 distribution map of saturated fluid and a summation curve are obtained; a T2 distribution map of effective fluid is obtained; a T2 distribution map of irreducible fluid and saturability Swi of bound water are obtained; a T2 distribution map of surplus water and water saturation Sw are obtained; the T2 distribution maps of the fluids are converted into a pore size distribution map, the shale clay deadline and the irreducible fluid deadline are obtained, and then the shale micropore size and fluid distribution are obtained. The nuclear magnetic resonance spectrometer is adopted, the pore size and distribution of the shale and size and distribution positions of water drops in the pores are analyzed quantitatively and qualitatively, and the result is reliable.

A method and apparatus are provided for measuring a parameter such as capillary pressure in porous media such as rock samples. The method comprises mounting a sample in a centrifuge such that different portions of the sample are spaced at different distances from the centrifuge axis, rotating the sample about the axis, measuring a first parameter in the different portions of the sample, and determining the value of a second parameter related to the force to which each portion is subjected due to rotation of the sample. In one embodiment, the first parameter is relative saturation of the sample as measured by MRI techniques, and the second parameter is capillary pressure.

A method and apparatus for obtaining a parameter of interest relating to a region proximate a nuclear magnetic resonance (NMR) logging tool suitable for subterranean well logging is disclosed. The nuclei of the region are subjected to a pulsed NMR technique and are productive of NMR logging data, the nuclei of the region characteristically having a longitudinal relaxation time T₁ distribution and an apparent transverse relaxation time T_2app distribution. In response to the NMR logging data, an R distribution is defined as R=T₁/T_2app, the T_2app and R distributions are processed as separate bins, along with the NMR logging data, according to a two-dimensional inversion model, and a signal intensity map of R versus T_2app is provided that is representative of the parameter of interest relating to the region. In response to a high-intensity signal on the map being within a first range of T_2app values and a first range of R values, the presence of a light hydrocarbon within the region is identified.

The present invention relates to devices and method for dissolving solid polarised material while retaining a high level of polarisation. In an embodiment of the present invention a material is polarised in a strong magnetic field in a cryostat 2 and then brought into solution while still inside the cryostat 2.

A nuclear magnetic resonance apparatus that may be used in connection with a variety of different tools, including a down-hole side-wall coring tool as well as with manufacturing process controllers. In one embodiment, the nuclear magnetic resonance apparatus may include a magnet assembly constructed around a sample chamber. The magnet assembly is constructed and arranged to provide a non-uniform magnetic field having a known magnetic field gradient inside the sample chamber. The use of gradient fields may allow for a more flexible and robust magnet assembly design that may be suitable for a variety of different applications.

A disclosed evaluation testing method for damage of a drilling fluid to a compact gas reservoir comprises the following steps: drying a core sample, marking, performing uniform segmenting and slicing, and measuring the weight and other parameters of the dry core sample; putting the core segments into a fluid for infiltration and saturation; performing reverse centrifugation operation on the core segments, and acquiring the original water saturation Swi of the small core segment samples; measuring the nuclear magnetic resonance T2 spectrums of simulated stratum water and a filtrate of the drilling fluid and determining the difference; performing NMR imaging measurement on the fluid distribution state in the core; and putting the core segments into a core clamper of a drilling-fluid circulating instrument for measurement after the drilling fluid is circulated and calculating the water saturation Swi and the gas permeability K2 of the core segments, calculating the permeability damaging rate after infiltration of the drilling fluid by using the measurement results through comparison, so as to evaluate the damage degree caused by infiltration of the drilling fluid at different depths. The novel evaluation testing method for damage of a drilling fluid to compact and super compact gas reservoirs is established by improving an original slice method.

An apparatus and method for NMR analysis of a plurality of core samples includes a core holder (11) that holds a core sample under pressurized conditions. A radio frequency coil (51) disposed about the core holder (11) generates a pulsed-mode magnetic field component over a sample volume occupied by the core sample. A support structure is removably secured to the respective core holder. A permanent magnet (65A, 65B) has an open configuration such that it is removably disposed into a position within the support structure about the radio frequency coil and the core holder. The open configuration allows the same permanent magnet to be used for NMR analysis of a plurality of core samples without the need for depressurizing the respective core holder and disassembling the core holder and corresponding load frame for each core sample. It also allows multiple core samples to be prepared for NMR analysis while separated from the NMR measurement apparatus.

The invention relates to a method and a device for calculating effective porosity of a compact oil storage layer. The method comprises the following steps: preparing a saturate rock sample; performing nuclear magnetic resonance measurement on the saturate rock sample, thereby acquiring T2 point amplitude of the saturate rock sample, nuclear magnetic porosity of the saturate rock sample and total amplitude of T2 spectrum of the saturate rock sample; performing dewatering treatment on the saturate rock sample under an effect of centrifugal force and performing the nuclear magnetic resonance measurement, thereby acquiring the T2 point amplitude of the centrifugal rock sample, the nuclear magnetic porosity of the centrifugal rock sample and the total amplitude of T2 spectrum of the centrifugal rock sample; acquiring the porosity component of the T2 point of the saturate rock sample, the curve of T2 spectrum of the saturate rock sample, the porosity component of the T2 point of the centrifugal rock sample and the curve of T2 spectrum of the centrifugal rock sample; acquiring a T2 cut-off value according to the total amplitude of T2 spectrum of the saturate rock sample, the curve of T2 spectrum of the saturate rock sample, the total amplitude of T2 spectrum of the centrifugal rock sample and the curve of T2 spectrum of the centrifugal rock sample; utilizing the T2 cut-off value to acquire the valid saturability of the flowing fluid; calculating the effective porosity of the compact oil storage layer according to the valid saturability of the flowing fluid.

This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.

The invention relates to a rock core holder compatible with nuclear magnetic resonance, which can simulate pressures and temperatures of deep reservoirs, perform oil water displacement of a rock core under simulated formation conditions, and simultaneously perform nuclear magnetic resonance on-line measurement. According to the invention, a radio frequency coil is embedded in the rock core holder, and the signal to noise ratio is greatly increased when the rock core holder is compared with a conventional rock core holder. The rock core holder is made of nonmagnetic nonmetal materials, which avoids the damage of the magnetic field uniformity caused by magnetic materials, and also avoids the generation of eddy current in the holder by a pulse gradient. Compared with a conventional rock core holder, the invention not only greatly increases the signal to noise ratio, but also fully ensures the accuracy of nuclear magnetic resonance measurement results at a high temperature and a high pressure. The holder is applicable to on-line measurement of nuclear magnetic resonance relaxation spectra, diffusion-relaxation two-dimensional spectra, and imaging methods during rock core oil water displacement at a high temperature and a high pressure. In addition, the invention performs real-time tracking compensation of temperatures and pressures of ring-crush fluid, and thus ensures the reliability of rock core simulated formation conditions.

Methods and related systems are described for extracting information about a system of nuclear spins including: performing a plurality of Nuclear Magnetic Resonance (NMR) measurements on the system of nuclear spins; acquiring NMR data from each of the plurality of NMR measurements; performing data inversion using an random-sampler to generate an ensemble of spectra so as to extract information about the system of nuclear spins; and analyzing the performed random-sampler inversion results to extract information about the system of nuclear spins.

The invention discloses a method for quantitatively evaluating the pore throat change degree in a stress sensitive process. The method comprises the following steps: taking a rock core used for an experiment, washing oil and drying, and measuring the porosity and the gas measured permeability of the rock core; preparing simulated formation water used for the experiment, wherein the simulated formation water reaches a formation water mineralization degree; selecting the displacement velocity of the simulated formation water; placing the rock core in a rock core clamping device; applying a confining pressure for displacing the rock core with the simulated formation water; calculating the water measured permeability according to the inlet pressure of the rock core and the displacement velocity, and measuring the nuclear magnetic resonance T2 spectrum under the confining pressure; gradually rising the confining pressure, and measuring the nuclear magnetic resonance T2 spectrums under different confining pressures; converting the nuclear magnetic resonance T2 spectrums under different confining pressures into pore throat radiuses r; drawing a pore throat radius distribution curve under different confining pressures, and measuring the pore throat change degrees under different confining pressures. According to the method, on-line measurement can be performed in real time; samples are not required to be unloaded and loaded repeatedly; the influence on pore throat change caused by the change of the confining pressure in the unloading and loading processes is avoided; therefore, the pore throat change degree in the stress sensitive process is quantitatively evaluated.

An inspection system positions a balancing shim to asymmetrically balance a magnetic field generated by an inductive sensor, which forms part of the inspection system. Additionally, relays and capacitors used to tune the inductive sensor to a desired resonance frequency are geometrically arranged to minimize electrical interference generated by operation of the relays and capacitors. A shielding device, which may be formed on a printed circuit board, protects a magnetic field generated by the inductive sensor from external electromagnetic interference. A slot positioned in the inductive sensor may be used to tune a resonant mode of the inductive sensor to accurately and particularly detect metallic shanks and/or other metallic objects in shoes, socks, and/or clothing.