25 results about "Superparamagnetic nanoparticles" patented technology

The invention relates to the technical field of biomedicine, in particular to hyaluronic acid hydrogel for simulating magnetic regulation and control of cell adhesion performance of tumor ECM (extracellular matrix). The hydrogel is prepared from the following components in percentage by weight: 0.5 to 10 percent of thiolated polysaccharide, 0.01 to 2.5 percent of 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methyl propiophenone Irgacure2959, 0 to 100 [mu] g / mL of a superparamagnetic iron oxide nanorod SPIONR, 0 to 100 [mu] g / mL of a cell adhesion ligand and the balance of a solvent. According to the hyaluronic acid hydrogel capable of simulating the magnetic regulation and control of the cell adhesion performance of the tumor ECM, provided by the invention, the isotropic or anisotropic presentation of a cell adhesion ligand is regulated and controlled by magnetic arrangement through the magnetic nanorod coating soft hydrogel with a high aspect ratio; the hydrogel combines RGD modified superparamagnetic nanoparticles with a hyaluronic acid matrix, the arrangement of the nanoparticles is accurately regulated and controlled through an external magnetic field, and dynamic simulation of an ECM anisotropic topological structure is realized.

The invention discloses a black phosphorus-methylene blue nano composition for improving blood brain permeability and a synthesis method thereof. The synthesis method comprises the following steps: step 1, mixing black phosphorus nanosheets with polyethylene glycol for reaction; step 2, carrying out centrifugal cleaning on the reaction liquid in the step 1, and collecting a lower-layer reactant; step 3, adding aminated superparamagnetic nanoparticles and methylene blue into the lower reactant obtained in the step 2 for reaction; and 4, carrying out centrifugal cleaning on the reaction liquid obtained in the step 3, and collecting a lower-layer reactant. The invention also discloses the black phosphorus-methylene blue nano composition synthesized by the synthesis method, the drug loading rate of methylene blue in the composition exceeds 60%, and the composition has good biological safety, is non-toxic to cells and mice, is very simple and convenient in preparation process, and has a wide application prospect in the aspect of improving the blood-brain barrier permeability.

A method of preparing biotic super-paramagnetic nanoparticles can include combining a Colchicum ritchii plant extract with a ferric chloride solution to provide a mixture and adding sodium hydroxide solution to the mixture to provide the super-paramagnetic nanoparticles.

The application provides a kind of basic phosphatase induced T1 and T2 signal switching response type magnetic resonance imaging contrast agent and its preparation method and application, the response type magnetic resonance imaging contrast agent includes superparamagnetic nanoparticle, and polyethylene glycol phosphoric acid monoester modified to the surface of superparamagnetic nanoparticle;The superparamagnetic nanoparticle includes ferroferric oxide nanoparticle.The contrast agent of the application can realize T1 and T2 signal switching, is used for stem cell osteogenic differentiation monitoring, not only improves the detection sensitivity of magnetic resonance imaging to microstructure and function, also provides new tools and methods for stem cell treatment in biomedical research and clinical practice.

A medical device for retrieval of kidney stone fragments from a urinary tract is provided. The medical device has a plurality of magnets arranged within a flexible sheath forming a flexible wire. The magnets are magnetically attached end-to-end and arranged with their magnetic polarities alternating in direction. The magnetization direction of each of the magnets is orthogonal to the length axis of the flexible wire. A removable inner stylet is situated within the flexible sheath allowing for modifiable flexibility of the wire. The medical device is dimensioned to be introduced into the urinary tract and standard endoscopic devices. The medical device is further dimensioned to allow for the wire with magnetically attached stone fragments to be retrieved from the urinary tract. The magnetic field along the length axis is sufficient to attract to the surface of the flexible wire superparamagnetic nanoparticles which have bound themselves to kidney stone fragments.

The application relates to a magnetic cobalt-aluminum layered double hydroxide composite catalyst, a preparation method thereof and application of the catalyst in degradation of pesticides, and belongs to the field of environmental catalytic materials and water treatment technologies. The catalyst is composed of Fe3O4 superparamagnetic nanoparticles and Co5Al layered double hydroxide. Aluminum nitrate and cobalt nitrate are added into deionized water, then ammonium fluoride, urea and Fe3O4 superparamagnetic nanoparticles are added and ultrasonic dispersion is carried out, the obtained mixed solution is subjected to hydrothermal reaction, and after cooling, washing and drying, the catalyst is obtained. When used, the catalyst is added into water containing pesticides, peroxymonosulfate is added for oscillation reaction, and finally the catalyst is separated through an external magnetic field. The catalyst can be quickly separated and recovered through an external magnetic field, has good repeated use performance, good chemical stability and structural stability, high catalytic activity and strong anti-interference ability. The catalytic system reaction mechanism of the application is clear, and the free radical route is dominant, so that the degradation thoroughness and reliability are ensured.

The invention relates to superparamagnetic nanoparticles and a preparation method thereof, and belongs to the technical field of magnetic nanoparticles. The preparation method comprises the following steps: S1, uniformly mixing preparation raw materials in a solvent, vacuumizing, and then introducing inert gas until the air pressure is balanced; the preparation raw materials comprise a metal precursor, a surface ligand and a co-ligand. S2, maintaining a balanced inert atmosphere, and carrying out a three-stage reaction on the preparation raw materials in a solvent to obtain superparamagnetic nanoparticles; in the three-stage reaction, the temperature of the first-stage reaction is 100-150 DEG C, the temperature of the second-stage reaction is 160-260 DEG C, and the temperature of the third-stage reaction is 280-350 DEG C; according to the preparation method provided by the invention, the superparamagnetic nanoparticles which are stable in morphology, octahedral, uniform in particle size and free of mutual agglomeration of the particles can be prepared, the superparamagnetic characteristic and the high specific surface area are kept, stable operation can be ensured in application, and the superparamagnetic nanoparticles have very high application potential.

The application belongs to the technical field of biological probes, and relates to a PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe and a preparation method thereof. The PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe comprises a core, a covalent organic framework and a PD-L1 antibody, the core comprises a superparamagnetic nanoparticle, the covalent organic framework is coated on the surface of the core, and the PD-L1 antibody is combined on the surface of the covalent organic framework. The PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe prepared by the application can be transported into the body across the membrane, smoothly enter a PD-L1 positive malignant tumor lesion, and perform Raman imaging to microscopically distinguish the tumor boundary.

This invention provides a novel synthesis method for producing spherical monodisperse polymer beads that have adjustable diameter, good rigidity and good resistance to organic solvents, and contain sufficient hydrophilic functional groups to promote the uploading of a high percentage of superparamagnetic Fe3O4NP, enabling the production of new monodisperse superparamagnetic polymer beads in the 1-5 μm diameter range for IVD applications. [Solution] A monodisperse superparamagnetic bead having a core-shell structure. The bead includes: a core portion formed from a polystyrene polymer matrix material encapsulating a first batch of superparamagnetic Fe3O4 nanoparticles; a first shell portion directly located on the top of the core portion and formed from a crosslinked polymer matrix material composed of a styrene monomer, a crosslinkable monomer, and a first functional monomer having a functional group; and a second shell portion directly located on the top of the first shell portion.

Superparamagnetic nanoparticle-based analytical method comprising providing a sample having analytes in a sample matrix, providing a point of care chip having analytical regions, each of which is a stationary phase having at least one or more sections, labeling each of the analytes with a superparamagnetic nanoparticle and immobilizing the labeled analytes in the stationary phase, providing an analytical device having a means for exciting the superparamagnetic nanoparticles in vitro and a means for sensing, receiving, and transmitting response of the excited superparamagnetic nanoparticles, placing the chip in the analytical device and exciting the superparamagnetic nanoparticles in vitro, sensing, receiving, and transmitting the response of the superparamagnetic nanoparticles, and analyzing the response and determining characteristic of the analytes, wherein the response of the superparamagnetic nanoparticles comprises harmonics. The present invention also provides the hybrid point of care chip and analyzer to be used in the analytical method.

The application belongs to the technical field of biomedical engineering and relates to a superparamagnetic ferrite nanoparticle modified by a carboxyl-terminal NBDHEX prodrug as a ligand and a preparation method thereof. A dicarboxylic acid containing a disulfide bond is used as a connecting unit to react with NBDHEX to prepare a carboxyl-terminal NBDHEX prodrug, and then the carboxyl-terminal NBDHEX prodrug is used to perform ligand exchange on superparamagnetic ferrite nanoparticles stabilized by oleic acid on the surface, so as to construct a functional layer of the NBDHEX prodrug on the surface of the nanoparticles. In this way, the drug NBDHEX interfering with the redox metabolism balance in cells and the superparamagnetic nanoparticles capable of inducing an active oxygen related effect are integrated into one, and the coupling degree of the superparamagnetic ferrite nanoparticles and the drug NBDHEX in the intracellular action process is enhanced. The disulfide bond connecting unit can be broken in a reducing environment to release NBDHEX and / or an active derivative thereof, the intervention of the nanoparticles on the intracellular redox homeostasis is enhanced, and the nanoparticles are beneficial to the application in antitumor treatment.

The invention relates to intelligent sleep health equipment, in particular to a self-adaptive intelligent sleep-aiding sleeping bag and a sleep-aiding control method. The sleeping bag comprises a sleeping bag body, and a physiological sensing layer, a multi-element intervention execution layer and a central processing system are integrated on the sleeping bag body. The physiological sensing layer comprises a biochemical sensing unit based on a flexible fiber substrate, the hormone level change is detected by using superparamagnetic nanoparticles and a specific aptamer compound, and non-invasive continuous monitoring is realized; the multi-element intervention execution layer comprises a temperature control unit, a bionic massage unit, a multi-dimensional acoustic unit and an aromatherapy release module, and supports multi-mode sleep intervention; the central processing system receives the physiological signals, dynamically generates an intervention strategy according to the sleep stage and the physiological state and drives the execution layer to operate, and closed-loop regulation and control are formed. Through multi-mode perception and cooperative intervention, accurate monitoring and self-adaptive adjustment of the sleep process are realized, and the sleep quality is improved.

The invention relates to the field of magnetic nano materials, in particular to a superparamagnetic composite magnetic material and a preparation method and application thereof. The superparamagnetic composite magnetic material is of a jujube cake structure in which superparamagnetic nanoparticles are dispersed and embedded in a polymer matrix. The superparamagnetic composite magnetic material with the jujube cake structure has high saturation magnetization intensity; according to the preparation method disclosed by the invention, the superparamagnetic nano-particles can be prepared into the superparamagnetic composite magnetic material with a larger size, the prepared superparamagnetic composite magnetic material is high in saturation magnetization intensity, and the limitation of the size of the superparamagnetic nano-particles on the magnetic intensity is broken through; the superparamagnetic composite magnetic nano material with the jujube cake structure is suitable for preparing a demulsifier in oilfield development.

The invention belongs to the technical field of glass surface treatment, and discloses a glass fiber reinforced composite material and a preparation method thereof. The composite material comprises a thermosetting resin matrix and chopped glass fibers uniformly dispersed in the thermosetting resin matrix, and the surfaces of the chopped glass fibers are coated with a superparamagnetic nanoparticle layer; the superparamagnetic nano-particle layer is composed of ferroferric oxide nano-particles; the chopped glass fibers are arranged in the thermosetting resin matrix along a single direction, the orientation degree parameter of the chopped glass fibers is greater than 0.85, and the orientation degree parameter is defined as an average value of cosine square of an included angle between a fiber axial direction and a macroscopic orientation direction. The forming mechanism of passive distribution and random orientation of a traditional short fiber composite material is changed, and active and accurate regulation and control of the microconfiguration of the reinforced phase are achieved through a magnetization-magnetic field coupling strategy. The method does not need to change the main body structure of existing injection or mold pressing equipment, only needs to integrate an electromagnetic system on the periphery of the mold, and is high in process compatibility.

A method and apparatus for inhibiting bacterial biofilms using magnetically driven nanoparticles, belonging to the field of biomedical technology, addresses the problem of traditional antibiotics inhibiting bacterial biofilms. This method utilizes a magnetic field to drive the physical-mechanical movement of magnetic nanoparticles, synergistically inducing drug action, thus achieving better biofilm inhibition and is more suitable for eliminating drug-resistant bacteria. Furthermore, the designed apparatus for inhibiting bacterial biofilms using magnetically driven nanoparticles is small, easy to use, and highly practical. Compared to traditional antibiotics, this technology, combined with superparamagnetic nanoparticles, can be applied to wound healing, possessing significant commercial value.

A method of preparing biotic super-paramagnetic nanoparticles can include combining a Colchicum ritchii plant extract with a ferric chloride solution to provide a mixture and adding sodium hydroxide solution to the mixture to provide the super-paramagnetic nanoparticles.

This invention discloses a magnetron piezoelectric composite hydrogel and a method for preparing the composite hydrogel, comprising: modifying barium titanate with tannic acid to prepare tannic acid-functionalized barium titanate nanoparticles; modifying superparamagnetic Fe3O4 nanoparticles with carboxyl-terminated polyethylene glycol to obtain carboxylated superparamagnetic nanoparticles; uniformly dispersing the tannic acid-functionalized barium titanate nanoparticles and carboxylated superparamagnetic nanoparticles in deionized water to form a suspension, and then adding polyvinyl alcohol and glycerol to react and obtain the magnetron piezoelectric composite hydrogel. This invention also discloses the application of the above hydrogel in promoting the repair of peripheral nerve injuries. The composite hydrogel of this invention can remotely, non-invasively, and precisely convert mechanical stress into electrical signals that promote nerve regeneration, and can also exert anti-inflammatory and antioxidant stress-regulating microenvironment functions, providing a powerful intelligent platform for the functional regeneration of peripheral nerves.

The invention belongs to the technical field of photonic crystal display, and discloses a heat-assisted magnetic recording-erasing photonic crystal film which is composed of a flexible polymer matrix and a magnetic phase change photonic crystal embedded in the flexible polymer matrix. The magnetic phase-change photonic crystal comprises superparamagnetic nanoparticles and a magnetic color-fixing phase-change material, and the magnetic color-fixing phase-change material is a sorbitan fatty acid ester phase-change material or a polyoxyethylene ether phase-change material. In the crystal film, the flexible polymer matrix plays roles in flexible self-supporting, protecting and limiting the flowing of the magnetic phase-change photonic crystal, and the magnetic phase-change photonic crystal is combined, so that the obtained photonic crystal film is endowed with magnetic writing-stable display-erasing functions under a heat-assisted condition, and has the advantages of repeated writing, low-energy-consumption color display and the like; a new thought can be provided for preparation of display devices which are low in energy consumption and can be repeatedly used; the preparation method is simple, convenient to operate and suitable for popularization and application.

A medical device for retrieval of kidney stone fragments from a urinary tract is provided. The medical device has a plurality of magnets arranged within a flexible sheath forming a flexible wire. The magnets are magnetically attached end-to-end and arranged with their magnetic polarities alternating in direction. The magnetization direction of each of the magnets is orthogonal to the length axis of the flexible wire. A removable inner stylet is situated within the flexible sheath allowing for modifiable flexibility of the wire. The medical device is dimensioned to be introduced into the urinary tract and standard endoscopic devices. The medical device is further dimensioned to allow for the wire with magnetically attached stone fragments to be retrieved from the urinary tract. The magnetic field along the length axis is sufficient to attract to the surface of the flexible wire superparamagnetic nanoparticles which have bound themselves to kidney stone fragments.

This invention belongs to the field of photonic crystal display technology and discloses a heat-assisted magnetic recording-erasing photonic crystal film. It consists of a flexible polymer matrix and a magnetic phase-change photonic crystal embedded therein. The magnetic phase-change photonic crystal comprises superparamagnetic nanoparticles and a magneto-solid-color phase-change material, wherein the magneto-solid-color phase-change material is a sorbitan fatty acid ester-based phase-change material or a polyoxyethylene ether-based phase-change material. In the crystal film of this invention, the flexible polymer matrix plays a role in flexible self-support and protection, and restricts the flow of the magnetic phase-change photonic crystal. Combined with the magnetic phase-change photonic crystal, the resulting photonic crystal film is endowed with magnetic writing-stable display-erasing functions under heat-assisted conditions, possessing advantages such as repeated writing and low-energy color display. This provides a new approach for the fabrication of low-energy, reusable display devices. Furthermore, the fabrication method involved is relatively simple, easy to operate, and suitable for widespread application.

The invention discloses a flow battery diaphragm based on magnetic field induction, a preparation method and application thereof, and the preparation method comprises the following preparation steps: S1, dissolving a polymer base material, adding superparamagnetic nanoparticles, and uniformly dispersing to obtain a doped casting membrane solution; s2, a substrate is coated with the doped membrane casting solution, the substrate is placed in a magnetic field for induction, the superparamagnetic nanoparticles are arranged in order to form a micropore pre-structure, the doped membrane casting solution with the micropore pre-structure is cured, and a formed diaphragm is obtained; and S3, washing and drying the formed diaphragm, cutting, and carrying out surface modification by using a modifier to prepare the flow battery diaphragm based on magnetic field induction. According to the present invention, the magnetic field induction phase conversion pore forming process is adopted, and the magnetic field intensity and the direction are controlled, such that the precise regulation and control of the zinc-bromine flow battery diaphragm microporous structure is achieved, and the contradiction between the high ion conduction and the high selectivity in the traditional technology is solved.

A method of preparing biotic super-paramagnetic nanoparticles can include combining a Colchicum ritchii plant extract with a ferric chloride solution to provide a mixture and adding sodium hydroxide solution to the mixture to provide the super-paramagnetic nanoparticles.

The invention discloses a polymorphic detectable marker for breast tumor localization and a breast tumor localization method, and belongs to the technical field of tumor medical treatment. The breast tumor positioning polymorphic detectable marker comprises a puncture needle and a marker, the top of the puncture needle is provided with a pushing handle, the middle of the puncture needle is sleeved with a pushing part, the two sides of the pushing part are symmetrically provided with fixing circular rings, the surface of the pushing part is provided with an anti-triggering switch, and the pushing part is provided with an anti-triggering button. The marker is made of medical titanium alloy and is of a columnar structure, a positioning ball is arranged in the marker, and the positioning ball is embedded in the marker and is composed of a superparamagnetic nanoparticle layer and a high-density metal particle layer; the invention aims to solve the problem that a breast tumor positioning marker in the prior art cannot simultaneously meet the clinical requirements of long-term quantitative monitoring, low infection risk, convenient implantation and intraoperative positioning.

The invention discloses a composite non-metal pipeline with an electromagnetic temperature control function and a temperature control method, and relates to the technical field of pipelines, the composite non-metal pipeline comprises an inner layer temperature control unit, a middle electromagnetic unit and an outer layer structure reinforcing unit which are sequentially arranged from inside to outside; the inner-layer temperature control unit comprises an inner-layer base material, an outer-layer base material and a superparamagnetic nanoparticle coating clamped between the inner-layer base material and the outer-layer base material; the middle electromagnetic unit comprises an insulating carrier pipe and an electrified spiral coil wound on the outer surface of the insulating carrier pipe; and the outer-layer structure reinforcing unit is coated outside the middle electromagnetic unit to provide structure support. Through the electromagnetic induction principle and closed-loop control of the embedded temperature sensor, the temperature of the inner wall can be accurately controlled within the range of + / -1 DEG C of a set value. Through the temperature control capability, the efficiency and the effect of conveying the medium through the pipeline are obviously improved.

A method of preparing biotic super-paramagnetic nanoparticles can include combining a Colchicum ritchii plant extract with a ferric chloride solution to provide a mixture and adding sodium hydroxide solution to the mixture to provide the super-paramagnetic nanoparticles.