43 results about "Superparamagnetic nanoparticles" patented technology

The invention belongs to the technical field of biological medicine, and particularly relates to a method for detecting extracellular vesicle protein and application thereof. According to the invention, the design is optimized on the basis of the first-generation SENSORS technology, and a second-generation BarFllare high-sensitivity detection technology is developed. According to the technology, a gold nanoparticle-mediated three-function fluorescent probe controllable release system is integrated, a superparamagnetic nanoparticle-mediated fluorescent probe captures enrichment and enhances a fluorescent signal through a spherical hot spot aggregation effect, the detection sensitivity is improved by 31 times compared with that of a traditional ELISA method, and high-sensitivity detection (1.37-7.30 parts / mu L) of EVs protein is achieved. Compared with the first-generation SENSORS technology, the BarFllare detection time is shortened by 43.75%, and the cost is reduced by about 63%.

The invention relates to the technical field of biomedicine, in particular to hyaluronic acid hydrogel for simulating magnetic regulation and control of cell adhesion performance of tumor ECM (extracellular matrix). The hydrogel is prepared from the following components in percentage by weight: 0.5 to 10 percent of thiolated polysaccharide, 0.01 to 2.5 percent of 2-hydroxy-4 '-(2-hydroxyethoxy)-2-methyl propiophenone Irgacure2959, 0 to 100 [mu] g / mL of a superparamagnetic iron oxide nanorod SPIONR, 0 to 100 [mu] g / mL of a cell adhesion ligand and the balance of a solvent. According to the hyaluronic acid hydrogel capable of simulating the magnetic regulation and control of the cell adhesion performance of the tumor ECM, provided by the invention, the isotropic or anisotropic presentation of a cell adhesion ligand is regulated and controlled by magnetic arrangement through the magnetic nanorod coating soft hydrogel with a high aspect ratio; the hydrogel combines RGD modified superparamagnetic nanoparticles with a hyaluronic acid matrix, the arrangement of the nanoparticles is accurately regulated and controlled through an external magnetic field, and dynamic simulation of an ECM anisotropic topological structure is realized.

The invention discloses a black phosphorus-methylene blue nano composition for improving blood brain permeability and a synthesis method thereof. The synthesis method comprises the following steps: step 1, mixing black phosphorus nanosheets with polyethylene glycol for reaction; step 2, carrying out centrifugal cleaning on the reaction liquid in the step 1, and collecting a lower-layer reactant; step 3, adding aminated superparamagnetic nanoparticles and methylene blue into the lower reactant obtained in the step 2 for reaction; and 4, carrying out centrifugal cleaning on the reaction liquid obtained in the step 3, and collecting a lower-layer reactant. The invention also discloses the black phosphorus-methylene blue nano composition synthesized by the synthesis method, the drug loading rate of methylene blue in the composition exceeds 60%, and the composition has good biological safety, is non-toxic to cells and mice, is very simple and convenient in preparation process, and has a wide application prospect in the aspect of improving the blood-brain barrier permeability.

A method of preparing biotic super-paramagnetic nanoparticles can include combining a Colchicum ritchii plant extract with a ferric chloride solution to provide a mixture and adding sodium hydroxide solution to the mixture to provide the super-paramagnetic nanoparticles.

The application provides a kind of basic phosphatase induced T1 and T2 signal switching response type magnetic resonance imaging contrast agent and its preparation method and application, the response type magnetic resonance imaging contrast agent includes superparamagnetic nanoparticle, and polyethylene glycol phosphoric acid monoester modified to the surface of superparamagnetic nanoparticle;The superparamagnetic nanoparticle includes ferroferric oxide nanoparticle.The contrast agent of the application can realize T1 and T2 signal switching, is used for stem cell osteogenic differentiation monitoring, not only improves the detection sensitivity of magnetic resonance imaging to microstructure and function, also provides new tools and methods for stem cell treatment in biomedical research and clinical practice.

A medical device for retrieval of kidney stone fragments from a urinary tract is provided. The medical device has a plurality of magnets arranged within a flexible sheath forming a flexible wire. The magnets are magnetically attached end-to-end and arranged with their magnetic polarities alternating in direction. The magnetization direction of each of the magnets is orthogonal to the length axis of the flexible wire. A removable inner stylet is situated within the flexible sheath allowing for modifiable flexibility of the wire. The medical device is dimensioned to be introduced into the urinary tract and standard endoscopic devices. The medical device is further dimensioned to allow for the wire with magnetically attached stone fragments to be retrieved from the urinary tract. The magnetic field along the length axis is sufficient to attract to the surface of the flexible wire superparamagnetic nanoparticles which have bound themselves to kidney stone fragments.

The application relates to a magnetic cobalt-aluminum layered double hydroxide composite catalyst, a preparation method thereof and application of the catalyst in degradation of pesticides, and belongs to the field of environmental catalytic materials and water treatment technologies. The catalyst is composed of Fe3O4 superparamagnetic nanoparticles and Co5Al layered double hydroxide. Aluminum nitrate and cobalt nitrate are added into deionized water, then ammonium fluoride, urea and Fe3O4 superparamagnetic nanoparticles are added and ultrasonic dispersion is carried out, the obtained mixed solution is subjected to hydrothermal reaction, and after cooling, washing and drying, the catalyst is obtained. When used, the catalyst is added into water containing pesticides, peroxymonosulfate is added for oscillation reaction, and finally the catalyst is separated through an external magnetic field. The catalyst can be quickly separated and recovered through an external magnetic field, has good repeated use performance, good chemical stability and structural stability, high catalytic activity and strong anti-interference ability. The catalytic system reaction mechanism of the application is clear, and the free radical route is dominant, so that the degradation thoroughness and reliability are ensured.

The invention relates to superparamagnetic nanoparticles and a preparation method thereof, and belongs to the technical field of magnetic nanoparticles. The preparation method comprises the following steps: S1, uniformly mixing preparation raw materials in a solvent, vacuumizing, and then introducing inert gas until the air pressure is balanced; the preparation raw materials comprise a metal precursor, a surface ligand and a co-ligand. S2, maintaining a balanced inert atmosphere, and carrying out a three-stage reaction on the preparation raw materials in a solvent to obtain superparamagnetic nanoparticles; in the three-stage reaction, the temperature of the first-stage reaction is 100-150 DEG C, the temperature of the second-stage reaction is 160-260 DEG C, and the temperature of the third-stage reaction is 280-350 DEG C; according to the preparation method provided by the invention, the superparamagnetic nanoparticles which are stable in morphology, octahedral, uniform in particle size and free of mutual agglomeration of the particles can be prepared, the superparamagnetic characteristic and the high specific surface area are kept, stable operation can be ensured in application, and the superparamagnetic nanoparticles have very high application potential.

The invention belongs to the technical field of preparation of diagnosis and treatment drug-loading superparamagnetic nanoparticles, and particularly relates to a synthesis method of double-targeting drug-loading superparamagnetic nanoparticles for glioma diagnosis and treatment, the synthesis method comprises the following steps: S1, preparation and characterization of RexFe3-xO4; s2, preparation and characterization of Yb < 0.015 > Fe < 2.985 > O < 4 > (at) PEI-HA are carried out; s3, preparation and characterization of MET (at) Yb < 0.015 > Fe < 2.985 > O < 4 > (at) PEI-HA are carried out; s4, the in-vitro anti-tumor effect of the MET (at) Yb < 0.015 > Fe < 2.985 > O < 4 > (at) PEI-HA is analyzed; and S5, the in-vivo MRI-T2 imaging effect of the MET (at) Yb < 0.015 > Fe < 2.985 > O < 4 > (at) PEI-HA is analyzed. According to the invention, three treatment modes of MHT-PDT-CDT can be adopted for collaborative treatment, and meanwhile, the autophagy and ferroptosis capabilities of tumor cells are enhanced through MET and magnetic heat.

The present invention relates to a solid-state hydrogen storage tank and a hydrogen storage method, belonging to the field of hydrogen storage technology. The solid-state hydrogen storage tank includes a shell having a plurality of accommodating cavities arranged along the direction of gravity and interconnected, the shell being provided with a liquid inlet and a liquid outlet connected to the accommodating cavities; a tank body is detachably arranged in the shell, each accommodating cavity containing a tank body for containing a hydrogen storage medium; a portion of an air pipe is located in the shell and can be selectively connected to the interior of any tank body to allow hydrogen to enter or leave the interior of the tank body, or can be selectively isolated from the interior of any tank body, with at least one end of the air pipe located outside the shell; an electromagnetic coil is disposed in the tank body, the hydrogen storage medium includes superparamagnetic nanoparticles and hydrogen storage particles, the electromagnetic coil is used to provide a constant magnetic field to fix the superparamagnetic nanoparticles relative to the tank body, and the electromagnetic coil is also used to provide an alternating magnetic field to cause the superparamagnetic nanoparticles to generate heat.

The application discloses an OPM-based superparamagnetic nanoparticle relaxation signal detection system and method. The detection system comprises a magnetic nanoparticle module, an OPM array and a magnetic field generation module in a magnetic shielding environment, and a magnetic field control module and a data acquisition module connected therewith outside the magnetic shielding environment. The magnetic nanoparticle module is placed in a controllable magnetic field region of the magnetic field generation module to wait for magnetization, the OPM array receives the relaxation signal generated after the particle magnetization, and the magnetic field generation module is used for generating a particle magnetization field and a background field inside; the magnetic field control module receives a magnetic field module instruction of a host computer, and supplies power to the magnetic field generation module through a constant-voltage power supply; the data acquisition module is connected with the OPM array to collect the relaxation signal, simultaneously receives a magnetic field mode signal generated by the magnetic field control module, and transmits data back to the host computer. The application improves the particle magnetization device, and suppresses the magnetization background noise from the hardware.

The application belongs to the technical field of biological probes, and relates to a PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe and a preparation method thereof. The PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe comprises a core, a covalent organic framework and a PD-L1 antibody, the core comprises a superparamagnetic nanoparticle, the covalent organic framework is coated on the surface of the core, and the PD-L1 antibody is combined on the surface of the covalent organic framework. The PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe prepared by the application can be transported into the body across the membrane, smoothly enter a PD-L1 positive malignant tumor lesion, and perform Raman imaging to microscopically distinguish the tumor boundary.

This invention provides a novel synthesis method for producing spherical monodisperse polymer beads that have adjustable diameter, good rigidity and good resistance to organic solvents, and contain sufficient hydrophilic functional groups to promote the uploading of a high percentage of superparamagnetic Fe3O4NP, enabling the production of new monodisperse superparamagnetic polymer beads in the 1-5 μm diameter range for IVD applications. [Solution] A monodisperse superparamagnetic bead having a core-shell structure. The bead includes: a core portion formed from a polystyrene polymer matrix material encapsulating a first batch of superparamagnetic Fe3O4 nanoparticles; a first shell portion directly located on the top of the core portion and formed from a crosslinked polymer matrix material composed of a styrene monomer, a crosslinkable monomer, and a first functional monomer having a functional group; and a second shell portion directly located on the top of the first shell portion.

Superparamagnetic nanoparticle-based analytical method comprising providing a sample having analytes in a sample matrix, providing a point of care chip having analytical regions, each of which is a stationary phase having at least one or more sections, labeling each of the analytes with a superparamagnetic nanoparticle and immobilizing the labeled analytes in the stationary phase, providing an analytical device having a means for exciting the superparamagnetic nanoparticles in vitro and a means for sensing, receiving, and transmitting response of the excited superparamagnetic nanoparticles, placing the chip in the analytical device and exciting the superparamagnetic nanoparticles in vitro, sensing, receiving, and transmitting the response of the superparamagnetic nanoparticles, and analyzing the response and determining characteristic of the analytes, wherein the response of the superparamagnetic nanoparticles comprises harmonics. The present invention also provides the hybrid point of care chip and analyzer to be used in the analytical method.

The invention relates to the technical field of medical imaging, in particular to alpha-methyltryptophan chelated superparamagnetic nanoparticles for epileptic focus localization and a preparation method and application of the alpha-methyltryptophan chelated superparamagnetic nanoparticles for epileptic focus localization, the nanoparticles comprise: a superparamagnetic iron oxide core, the average particle size of the superparamagnetic iron oxide core being 8.0-25.0 nanometers; the surface of the superparamagnetic iron oxide core is coated with the polyethylene glycol coating layer; the alpha-methyl tryptophan molecules are covalently linked to the polyethylene glycol coating layer through amido bonds, and the alpha-methyl tryptophan molecules are covalently linked to the polyethylene glycol coating layer through amido bonds; wherein the superparamagnetic iron oxide core accounts for 25.0-45.0% of the total weight of the nano particle, the polyethylene glycol coating layer accounts for 40.0-60.0% of the total weight of the nano particle, the alpha-methyltryptophan accounts for 5.0-15.0% of the total weight of the nano particle, and the nano particle can be selectively enriched in an epilepsy focus area by utilizing the specific targeting effect of the alpha-methyltryptophan, so that the epilepsy focus area can be enriched in the epilepsy focus area; and the epileptic focus positioning specificity and accuracy are improved.

The application provides a tumor contrast agent for enhancing magnetic resonance transverse relaxation signals in a weak acid environment, a preparation method and application thereof, and belongs to the technical field of biomedical engineering; the tumor contrast agent is formed by hydrophobic interaction between a comb-shaped anionic pH-sensitive macromolecule with a phase transition pH value of 6.5-6.8 and a surface oleic acid-stabilized hydrophobic superparamagnetic nanoparticle; the tumor contrast agent has a small hydration particle size (20nm-50nm), a low transverse relaxation rate (low R2) and good hydrophilicity in a physiological environment (pH value is 7.35-7.45), can be retained in tumor tissues through the EPR effect, and can leak into the inside of tumor tissues; the tumor contrast agent can improve the contrast ratio of tumor tissues / normal tissues in magnetic resonance imaging, and further improve the accuracy of early diagnosis of tumors.

A coated proppant including a particulate substrate, a first polymeric layer surrounding the particulate substrate, and a second polymeric layer surrounding the first polymeric layer. The first polymeric layer may include chemical additives. The second polymeric layer may include chemical tracers. The chemical tracers include barcoded degradable polymers, fluorescent dyes, quantum dot nanoparticles, superparamagnetic nanoparticles, up-conversion phosphors, long-persistent phosphors, time-resolved fluorescence resonance energy transfer polymer-nanoparticles (TR-FRET), or combinations thereof.

The application belongs to the technical field of biomedical engineering and relates to a superparamagnetic ferrite nanoparticle modified by a carboxyl-terminal NBDHEX prodrug as a ligand and a preparation method thereof. A dicarboxylic acid containing a disulfide bond is used as a connecting unit to react with NBDHEX to prepare a carboxyl-terminal NBDHEX prodrug, and then the carboxyl-terminal NBDHEX prodrug is used to perform ligand exchange on superparamagnetic ferrite nanoparticles stabilized by oleic acid on the surface, so as to construct a functional layer of the NBDHEX prodrug on the surface of the nanoparticles. In this way, the drug NBDHEX interfering with the redox metabolism balance in cells and the superparamagnetic nanoparticles capable of inducing an active oxygen related effect are integrated into one, and the coupling degree of the superparamagnetic ferrite nanoparticles and the drug NBDHEX in the intracellular action process is enhanced. The disulfide bond connecting unit can be broken in a reducing environment to release NBDHEX and / or an active derivative thereof, the intervention of the nanoparticles on the intracellular redox homeostasis is enhanced, and the nanoparticles are beneficial to the application in antitumor treatment.

The invention relates to intelligent sleep health equipment, in particular to a self-adaptive intelligent sleep-aiding sleeping bag and a sleep-aiding control method. The sleeping bag comprises a sleeping bag body, and a physiological sensing layer, a multi-element intervention execution layer and a central processing system are integrated on the sleeping bag body. The physiological sensing layer comprises a biochemical sensing unit based on a flexible fiber substrate, the hormone level change is detected by using superparamagnetic nanoparticles and a specific aptamer compound, and non-invasive continuous monitoring is realized; the multi-element intervention execution layer comprises a temperature control unit, a bionic massage unit, a multi-dimensional acoustic unit and an aromatherapy release module, and supports multi-mode sleep intervention; the central processing system receives the physiological signals, dynamically generates an intervention strategy according to the sleep stage and the physiological state and drives the execution layer to operate, and closed-loop regulation and control are formed. Through multi-mode perception and cooperative intervention, accurate monitoring and self-adaptive adjustment of the sleep process are realized, and the sleep quality is improved.

The invention is directed to hydrophilic and hydrophobic superparamagnetic nanoparticles and their use as contrast agents for NMR including agents that distinguish oil and water in NMR logging of geological formations containing oil or water. Methods of making these SPIONs are also described.

The invention relates to the field of magnetic nano materials, in particular to a superparamagnetic composite magnetic material and a preparation method and application thereof. The superparamagnetic composite magnetic material is of a jujube cake structure in which superparamagnetic nanoparticles are dispersed and embedded in a polymer matrix. The superparamagnetic composite magnetic material with the jujube cake structure has high saturation magnetization intensity; according to the preparation method disclosed by the invention, the superparamagnetic nano-particles can be prepared into the superparamagnetic composite magnetic material with a larger size, the prepared superparamagnetic composite magnetic material is high in saturation magnetization intensity, and the limitation of the size of the superparamagnetic nano-particles on the magnetic intensity is broken through; the superparamagnetic composite magnetic nano material with the jujube cake structure is suitable for preparing a demulsifier in oilfield development.

The invention belongs to the technical field of glass surface treatment, and discloses a glass fiber reinforced composite material and a preparation method thereof. The composite material comprises a thermosetting resin matrix and chopped glass fibers uniformly dispersed in the thermosetting resin matrix, and the surfaces of the chopped glass fibers are coated with a superparamagnetic nanoparticle layer; the superparamagnetic nano-particle layer is composed of ferroferric oxide nano-particles; the chopped glass fibers are arranged in the thermosetting resin matrix along a single direction, the orientation degree parameter of the chopped glass fibers is greater than 0.85, and the orientation degree parameter is defined as an average value of cosine square of an included angle between a fiber axial direction and a macroscopic orientation direction. The forming mechanism of passive distribution and random orientation of a traditional short fiber composite material is changed, and active and accurate regulation and control of the microconfiguration of the reinforced phase are achieved through a magnetization-magnetic field coupling strategy. The method does not need to change the main body structure of existing injection or mold pressing equipment, only needs to integrate an electromagnetic system on the periphery of the mold, and is high in process compatibility.

The application provides a kind of basic phosphatase induced T1 and T2 signal switching response type magnetic resonance imaging contrast agent and its preparation method and application, the response type magnetic resonance imaging contrast agent includes superparamagnetic nanoparticle, and polyethylene glycol phosphoric acid monoester modified to the surface of superparamagnetic nanoparticle;The superparamagnetic nanoparticle includes ferroferric oxide nanoparticle.The contrast agent of the application can realize T1 and T2 signal switching, is used for stem cell osteogenic differentiation monitoring, not only improves the detection sensitivity of magnetic resonance imaging to microstructure and function, also provides new tools and methods for stem cell treatment in biomedical research and clinical practice.

A novel nanocomposite made of superparamagnetic nanoparticles, gold nanoparticles and reduced graphene oxide porous nanosheets is synthesized. The novelty of the nanocomposite lies in three main factors: the porosity of the reduced graphene oxide sheet, the magnetization of the superparamagnetic nanoparticles and the biocompatibility and near infrared absorbance of the gold nanoparticles all in one nanocomposite that does not disassemble when administered in the body. All of which are joined to create a whole and singular nanocomposite that can emit heat due to magnetic energy, become as biocompatible as possible and conceivably allow for near infrared absorbance penetration while the nanocomposite is fully assembled.

A method and apparatus for inhibiting bacterial biofilms using magnetically driven nanoparticles, belonging to the field of biomedical technology, addresses the problem of traditional antibiotics inhibiting bacterial biofilms. This method utilizes a magnetic field to drive the physical-mechanical movement of magnetic nanoparticles, synergistically inducing drug action, thus achieving better biofilm inhibition and is more suitable for eliminating drug-resistant bacteria. Furthermore, the designed apparatus for inhibiting bacterial biofilms using magnetically driven nanoparticles is small, easy to use, and highly practical. Compared to traditional antibiotics, this technology, combined with superparamagnetic nanoparticles, can be applied to wound healing, possessing significant commercial value.

A method of preparing biotic super-paramagnetic nanoparticles can include combining a Colchicum ritchii plant extract with a ferric chloride solution to provide a mixture and adding sodium hydroxide solution to the mixture to provide the super-paramagnetic nanoparticles.

This invention discloses a magnetron piezoelectric composite hydrogel and a method for preparing the composite hydrogel, comprising: modifying barium titanate with tannic acid to prepare tannic acid-functionalized barium titanate nanoparticles; modifying superparamagnetic Fe3O4 nanoparticles with carboxyl-terminated polyethylene glycol to obtain carboxylated superparamagnetic nanoparticles; uniformly dispersing the tannic acid-functionalized barium titanate nanoparticles and carboxylated superparamagnetic nanoparticles in deionized water to form a suspension, and then adding polyvinyl alcohol and glycerol to react and obtain the magnetron piezoelectric composite hydrogel. This invention also discloses the application of the above hydrogel in promoting the repair of peripheral nerve injuries. The composite hydrogel of this invention can remotely, non-invasively, and precisely convert mechanical stress into electrical signals that promote nerve regeneration, and can also exert anti-inflammatory and antioxidant stress-regulating microenvironment functions, providing a powerful intelligent platform for the functional regeneration of peripheral nerves.

The invention belongs to the technical field of photonic crystal display, and discloses a heat-assisted magnetic recording-erasing photonic crystal film which is composed of a flexible polymer matrix and a magnetic phase change photonic crystal embedded in the flexible polymer matrix. The magnetic phase-change photonic crystal comprises superparamagnetic nanoparticles and a magnetic color-fixing phase-change material, and the magnetic color-fixing phase-change material is a sorbitan fatty acid ester phase-change material or a polyoxyethylene ether phase-change material. In the crystal film, the flexible polymer matrix plays roles in flexible self-supporting, protecting and limiting the flowing of the magnetic phase-change photonic crystal, and the magnetic phase-change photonic crystal is combined, so that the obtained photonic crystal film is endowed with magnetic writing-stable display-erasing functions under a heat-assisted condition, and has the advantages of repeated writing, low-energy-consumption color display and the like; a new thought can be provided for preparation of display devices which are low in energy consumption and can be repeatedly used; the preparation method is simple, convenient to operate and suitable for popularization and application.

A medical device for retrieval of kidney stone fragments from a urinary tract is provided. The medical device has a plurality of magnets arranged within a flexible sheath forming a flexible wire. The magnets are magnetically attached end-to-end and arranged with their magnetic polarities alternating in direction. The magnetization direction of each of the magnets is orthogonal to the length axis of the flexible wire. A removable inner stylet is situated within the flexible sheath allowing for modifiable flexibility of the wire. The medical device is dimensioned to be introduced into the urinary tract and standard endoscopic devices. The medical device is further dimensioned to allow for the wire with magnetically attached stone fragments to be retrieved from the urinary tract. The magnetic field along the length axis is sufficient to attract to the surface of the flexible wire superparamagnetic nanoparticles which have bound themselves to kidney stone fragments.

The invention discloses a bone repair porous tissue engineering scaffold with electromagnetic response as well as a preparation method and application thereof, and belongs to the field of medical materials. According to the invention, superparamagnetic nanoparticles are uniformly embedded into a high-molecular bionic porous scaffold, and a 3D printing technology is combined, so that the hierarchical porous scaffold with both macroscopic mechanical strength and microscopic biological activity is constructed. A porous structure is used for simulating an extracellular matrix of a bone, and the osseointegration efficiency is optimized. Meanwhile, in combination with the electromagnetic response characteristic of the stent, osteogenic differentiation of mesenchymal stem cells is dynamically regulated and induced and angiogenesis is accelerated through an external electromagnetic field, and a new-generation repair stent with mechanical adaptability, biological activity and intelligent responsiveness is provided for clinical refractory bone defects through interdisciplinary technology fusion; therefore, a'material-cell-microenvironment 'triple synergistic repair mechanism is realized.