Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method of thermo-magnetic dual responsive mesoporous silicon microspheres

A dual-response, mesoporous silicon technology, applied in the preparation of microspheres, microcapsule preparations, chemical instruments and methods, etc., can solve the problems of non-targeting and lower bioavailability of drugs, and achieve good biocompatibility properties, good application prospects, and mild reaction conditions

Inactive Publication Date: 2014-01-08
NANCHANG UNIV
View PDF3 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although the temperature-responsive mesoporous silicon microspheres grafted with PNIPAAm can achieve controlled release of drugs, the drug-loaded particles are not targeted, which reduces the bioavailability of drugs.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method of thermo-magnetic dual responsive mesoporous silicon microspheres
  • Preparation method of thermo-magnetic dual responsive mesoporous silicon microspheres
  • Preparation method of thermo-magnetic dual responsive mesoporous silicon microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Synthesis of magnetic nanoparticles. Superparamagnetic nanoparticles were synthesized by co-precipitation method, the specific process is as follows: Weigh 1.45 g FeSO 4 ·7H 2 O and 1.62 g FeCl 3 Dissolve in 100 mL of deionized water, fill with N 2 Divide O 2 After 20 min, when the water temperature was heated to 60°C under stirring, 5 mL of ammonia water was quickly added, and the mixed solution immediately turned black. After the mixed solution was reacted for 60 min, the black product was separated with a permanent magnet, washed with deionized water 4 times to remove residual ammonia, and finally placed in a 40° C. vacuum oven for drying for subsequent use. (2) Fe 3 o 4 SiO 2 Preparation of nanoparticles. Weigh 0.12 g of the superparamagnetic Fe prepared above 3 o 4 Nanoparticles were ultrasonically dispersed into 80 mL of absolute ethanol, then 5 mL of ammonia water was added, and 1 mL of TEOS was added drop by drop under stirring conditions, and reac...

Embodiment 2

[0026] (1) Synthesis of magnetic nanoparticles. Superparamagnetic nanoparticles were synthesized by co-precipitation method, the specific process is as follows: Weigh 2.24g FeSO 4 ·7H 2 O and 2.46 g FeCl 3 Dissolve in 100mL deionized water, fill with N 2 Divide O 2 After 30 min, when the water temperature was heated to 60°C with stirring, 10 mL of ammonia water was added quickly, and the mixed solution immediately turned black. After the mixed solution was reacted for 60 min, the black product was separated with a permanent magnet, washed with deionized water four times to remove residual ammonia, and finally dried in a vacuum oven at 50 °C for future use. (2) Fe 3 o 4 SiO 2 Preparation of nanoparticles. Weigh 0.25g of the superparamagnetic Fe prepared above 3 o 4 Nanoparticles were ultrasonically dispersed into 90 mL of absolute ethanol, then 5 mL of ammonia water was added, and 1 mL of TEOS was added drop by drop under stirring conditions, and reacted at room tempe...

Embodiment 3

[0028] (1) Synthesis of magnetic nanoparticles. Superparamagnetic nanoparticles were synthesized by co-precipitation method, the specific process is as follows: Weigh 3.25g FeSO 4 ·7H 2 O and 3.45 g FeCl 3 Dissolve in 100 mL of deionized water, fill with N 2 Divide O 2 60min, when the water temperature was heated to 60 °C under the condition of stirring, 5mL ammonia water was added rapidly, and the mixed solution turned black immediately. After the mixed solution was reacted for 60 min, the black product was separated with a permanent magnet, washed with deionized water 4 times to remove residual ammonia, and finally dried in a vacuum oven at 60°C for future use. (2) Fe 3 o 4 SiO 2 Preparation of nanoparticles. Weigh 0.5 g of the above-prepared superparamagnetic Fe 3 o 4 Nanoparticles were ultrasonically dispersed into 100 mL of absolute ethanol, then 5 mL of ammonia water was added, and 1 mL of TEOS was added drop by drop under stirring conditions, and reacted at ro...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a preparation method of thermo-magnetic dual responsive mesoporous silicon microspheres. The preparation method comprises the following steps: 1) synthesis of magnetic nanoparticles; 2) preparation of Fe3O4@SiO2 nanoparticles; 3) synthesis of magnetic responsive mesoporous silicon microspheres [M-MSN-CTAB (Magnetic-Mesoporous Silicon Nanoparticle-Cetyltrimethyl Ammonium Bromide)]; 4) modification of M-MSN-CATB; 5) preparation of the thermo-magnetic dual responsive mesoporous silicon microspheres [M-MSN-PNIPAAm (Poly N-Isopropyl Acryl Amide)]. The preparation method provided by the invention is reasonable in design method and simple and feasible in operation, and can be used for successfully preparing novel thermo-magnetic dual responsive M-MSN by taking superparamagnetic Fe3O4 nanoparticles as a core, mesoporous silicon as a middle interlayer and a temperature sensitive copolymer as a shell. The M-MSN-PNIPAAm has the characteristics of superparamagnetism, high specific surface area and high pore volume of mesoporous silicon and temperature response. The M-MSN-PNIPAAm can be used as a carrier of medicines to prevent medicines and active components from being damaged, and purpose of targeted delivery and controlled release is realized.

Description

technical field [0001] The invention belongs to the technical field of preparation of inorganic materials, and in particular relates to a method for preparing mesoporous silicon microspheres with dual thermal and magnetic responses. Background technique [0002] Due to the superior characteristics of mesoporous silicon itself (such as large specific surface area, high mesoporous volume, adjustable mesopore diameter, easy surface modification, etc.), mesoporous silicon has become a research hotspot for many researchers. At the same time, mesoporous silicon also has the characteristics of good biocompatibility, physical and chemical stability and low toxicity, so mesoporous silicon is widely used in the fields of sensors, catalysis, separation and drug delivery. Due to the adjustable pore size of mesoporous silicon, it is suitable for the loading and delivery of drug molecules or bioactive molecules of various sizes, shapes and functions. However, this kind of mesoporous sil...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02B01J20/26B01J20/30A61K47/34A61K47/04C08F292/00
Inventor 熊华宁方建王深琪董丽玲彭海龙陈莎王素芳罗美赵强朱雪梅黎文建
Owner NANCHANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com