The invention relates to a preparation method of a hollow
mesoporous silica nanoparticle. The preparation method comprises the following steps: obtaining a
polymer-silica composite
nanoparticle having a core-shell structure by adopting spherical aggregations of an amphiphilic segmented
copolymer in an
aqueous solution and a cationic surfactant hexadecyl trimethyl
ammonium bromide as double templates and ethyl
orthosilicate as a
silicon source and by hydrolyzing the
silicon source under an alkaline condition; and calcining to remove the templates to obtain the hollow
mesoporous silica nanoparticle. The preparation method has the advantages of simplicity, mild reaction condition, and cheap experiment raw materials, and the prepared
mesoporous silica nanoparticle has the advantages of high specific surface area, high pore volume, and good biological compatibility. The hollow structure enables the
drug loading amount to be substantially improved, nanometer gold, nanometer silver, magnetic
iron oxide particles,
quantum dots, a contrast agent and the like to be loaded, so the hollow mesoporous
silica nanoparticle can be used as a targeting
drug release carrier, can be used for magnetic
resonance image analysis, and has good application prospects in the fields of the diagnosis and the treatment of cancers.