Preparation method of hollow mesoporous silica nanoparticle

A technology of mesoporous silicon dioxide and nanoparticles, applied in the direction of silicon dioxide, silicon oxide, nanotechnology, etc., can solve the problems of limited drug loading of mesoporous silicon nanoparticles combined with other functional materials, limited use range, etc. Achieve the effect of low price, low density and good economy

Inactive Publication Date: 2012-11-21
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the drug loading capacity of mesoporous silicon nanoparticles prepared by traditional methods is limited, and it is difficult to c...

Method used

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  • Preparation method of hollow mesoporous silica nanoparticle
  • Preparation method of hollow mesoporous silica nanoparticle
  • Preparation method of hollow mesoporous silica nanoparticle

Examples

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Embodiment 1

[0029] Amphiphilic polymer PAA 4 -b-PS 34 Preparation of hollow mesoporous silica from aggregates as templates

[0030] (1) Weigh 0.2g cetyltrimethylammonium bromide and dissolve it in 80ml pure water, add 3ml NH under 400r / min stirring condition on a magnetic stirrer 3 ·H 2 O.

[0031] (2) Weigh out 0.08g amphiphilic block polymer PS under 400r / min stirring conditions 34 -b-PAA 4 Dissolve it in 16ml of tetrahydrofuran THF. After it is completely dissolved, add it dropwise to the solution obtained in step (1), continue to stir for 10min under stirring conditions of 400r / min, and dilute with 160ml of absolute ethanol to obtain a dilution.

[0032] (3) Dilute 0.6g (0.603ml) ethyl orthosilicate TEOS in 10ml ethanol, and then add it dropwise to the diluent obtained in step (2), and stir at 400r / min for 24h at room temperature.

[0033] (4) At the end of the reaction, centrifuge, dry the precipitate at 50°C for 1.5h, and then calcinate at 550°C for 6h to obtain hollow mesoporous silicon nan...

Embodiment 2

[0035] Amphiphilic polymer PAA 4 -b-PS 58 Preparation of hollow mesoporous silicon from aggregates as templates

[0036] (1) Weigh 0.2g cetyltrimethylammonium bromide and dissolve it in 80ml pure water, add 3ml NH under 400r / min stirring condition on a magnetic stirrer 3 ·H 2 O.

[0037] (2) Under 400r / min stirring conditions, weigh out 0.1g amphiphilic block polymer PS 58 -b-PAA 4 Dissolve it in 16ml of tetrahydrofuran. After it is completely dissolved, add it dropwise to the solution obtained in step (1), continue to stir for 10min under stirring conditions of 400r / min, and dilute with 160ml of absolute ethanol to obtain a dilution.

[0038] (3) Dilute 0.6g (0.603ml) ethyl orthosilicate TEOS in 10ml ethanol, and then add it dropwise to the diluent obtained in step (2), and stir at 400r / min for 24h at room temperature.

[0039] (4) At the end of the reaction, centrifuge, and dry the precipitate at 50°C for 1.5h, and then calcinate at 550°C for 6h to obtain hollow mesoporous silicon na...

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Abstract

The invention relates to a preparation method of a hollow mesoporous silica nanoparticle. The preparation method comprises the following steps: obtaining a polymer-silica composite nanoparticle having a core-shell structure by adopting spherical aggregations of an amphiphilic segmented copolymer in an aqueous solution and a cationic surfactant hexadecyl trimethyl ammonium bromide as double templates and ethyl orthosilicate as a silicon source and by hydrolyzing the silicon source under an alkaline condition; and calcining to remove the templates to obtain the hollow mesoporous silica nanoparticle. The preparation method has the advantages of simplicity, mild reaction condition, and cheap experiment raw materials, and the prepared mesoporous silica nanoparticle has the advantages of high specific surface area, high pore volume, and good biological compatibility. The hollow structure enables the drug loading amount to be substantially improved, nanometer gold, nanometer silver, magnetic iron oxide particles, quantum dots, a contrast agent and the like to be loaded, so the hollow mesoporous silica nanoparticle can be used as a targeting drug release carrier, can be used for magnetic resonance image analysis, and has good application prospects in the fields of the diagnosis and the treatment of cancers.

Description

Technical field [0001] The invention belongs to the field of preparing silica nanoparticles, and particularly relates to a method for preparing hollow mesoporous silica nanoparticles. Background technique [0002] Since the first synthesis of MCM series mesoporous silicon by Mobil Company in 1992, due to the characteristics of good biocompatibility, large specific surface area, large specific pore volume, uniform and adjustable pore structure and easy modification of the surface, mesoporous silicon nanoparticles are used as drug control The potential of the release carrier has received widespread attention. Various mesoporous silicon nanoparticles with different pore structure, particle size, pore size and surface modification were synthesized successively. However, the drug loading of mesoporous silicon nanoparticles prepared by traditional methods is limited, and it is difficult to compound other functional materials such as quantum dots, contrast agents, magnetic nanoparticle...

Claims

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Application Information

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IPC IPC(8): C01B33/12B82Y30/00
Inventor 何创龙程晓胡金伟仇可新冯炜
Owner DONGHUA UNIV
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