6 results about "Superparamagnetic nanoparticle" patented technology

The application provides a kind of basic phosphatase induced T1 and T2 signal switching response type magnetic resonance imaging contrast agent and its preparation method and application, the response type magnetic resonance imaging contrast agent includes superparamagnetic nanoparticle, and polyethylene glycol phosphoric acid monoester modified to the surface of superparamagnetic nanoparticle;The superparamagnetic nanoparticle includes ferroferric oxide nanoparticle.The contrast agent of the application can realize T1 and T2 signal switching, is used for stem cell osteogenic differentiation monitoring, not only improves the detection sensitivity of magnetic resonance imaging to microstructure and function, also provides new tools and methods for stem cell treatment in biomedical research and clinical practice.

The application relates to a magnetic cobalt-aluminum layered double hydroxide composite catalyst, a preparation method thereof and application of the catalyst in degradation of pesticides, and belongs to the field of environmental catalytic materials and water treatment technologies. The catalyst is composed of Fe3O4 superparamagnetic nanoparticles and Co5Al layered double hydroxide. Aluminum nitrate and cobalt nitrate are added into deionized water, then ammonium fluoride, urea and Fe3O4 superparamagnetic nanoparticles are added and ultrasonic dispersion is carried out, the obtained mixed solution is subjected to hydrothermal reaction, and after cooling, washing and drying, the catalyst is obtained. When used, the catalyst is added into water containing pesticides, peroxymonosulfate is added for oscillation reaction, and finally the catalyst is separated through an external magnetic field. The catalyst can be quickly separated and recovered through an external magnetic field, has good repeated use performance, good chemical stability and structural stability, high catalytic activity and strong anti-interference ability. The catalytic system reaction mechanism of the application is clear, and the free radical route is dominant, so that the degradation thoroughness and reliability are ensured.

The application belongs to the technical field of biological probes, and relates to a PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe and a preparation method thereof. The PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe comprises a core, a covalent organic framework and a PD-L1 antibody, the core comprises a superparamagnetic nanoparticle, the covalent organic framework is coated on the surface of the core, and the PD-L1 antibody is combined on the surface of the covalent organic framework. The PD-L1 guided specific targeted CTC detection combined with tumor boundary distinguishing biological probe prepared by the application can be transported into the body across the membrane, smoothly enter a PD-L1 positive malignant tumor lesion, and perform Raman imaging to microscopically distinguish the tumor boundary.

The application belongs to the technical field of biomedical engineering and relates to a superparamagnetic ferrite nanoparticle modified by a carboxyl-terminal NBDHEX prodrug as a ligand and a preparation method thereof. A dicarboxylic acid containing a disulfide bond is used as a connecting unit to react with NBDHEX to prepare a carboxyl-terminal NBDHEX prodrug, and then the carboxyl-terminal NBDHEX prodrug is used to perform ligand exchange on superparamagnetic ferrite nanoparticles stabilized by oleic acid on the surface, so as to construct a functional layer of the NBDHEX prodrug on the surface of the nanoparticles. In this way, the drug NBDHEX interfering with the redox metabolism balance in cells and the superparamagnetic nanoparticles capable of inducing an active oxygen related effect are integrated into one, and the coupling degree of the superparamagnetic ferrite nanoparticles and the drug NBDHEX in the intracellular action process is enhanced. The disulfide bond connecting unit can be broken in a reducing environment to release NBDHEX and / or an active derivative thereof, the intervention of the nanoparticles on the intracellular redox homeostasis is enhanced, and the nanoparticles are beneficial to the application in antitumor treatment.

A method and apparatus for inhibiting bacterial biofilms using magnetically driven nanoparticles, belonging to the field of biomedical technology, addresses the problem of traditional antibiotics inhibiting bacterial biofilms. This method utilizes a magnetic field to drive the physical-mechanical movement of magnetic nanoparticles, synergistically inducing drug action, thus achieving better biofilm inhibition and is more suitable for eliminating drug-resistant bacteria. Furthermore, the designed apparatus for inhibiting bacterial biofilms using magnetically driven nanoparticles is small, easy to use, and highly practical. Compared to traditional antibiotics, this technology, combined with superparamagnetic nanoparticles, can be applied to wound healing, possessing significant commercial value.

This invention discloses a magnetron piezoelectric composite hydrogel and a method for preparing the composite hydrogel, comprising: modifying barium titanate with tannic acid to prepare tannic acid-functionalized barium titanate nanoparticles; modifying superparamagnetic Fe3O4 nanoparticles with carboxyl-terminated polyethylene glycol to obtain carboxylated superparamagnetic nanoparticles; uniformly dispersing the tannic acid-functionalized barium titanate nanoparticles and carboxylated superparamagnetic nanoparticles in deionized water to form a suspension, and then adding polyvinyl alcohol and glycerol to react and obtain the magnetron piezoelectric composite hydrogel. This invention also discloses the application of the above hydrogel in promoting the repair of peripheral nerve injuries. The composite hydrogel of this invention can remotely, non-invasively, and precisely convert mechanical stress into electrical signals that promote nerve regeneration, and can also exert anti-inflammatory and antioxidant stress-regulating microenvironment functions, providing a powerful intelligent platform for the functional regeneration of peripheral nerves.