4 results about "Ferrite nanoparticles" patented technology

The application belongs to the technical field of biomedical engineering and relates to a superparamagnetic ferrite nanoparticle modified by a carboxyl-terminal NBDHEX prodrug as a ligand and a preparation method thereof. A dicarboxylic acid containing a disulfide bond is used as a connecting unit to react with NBDHEX to prepare a carboxyl-terminal NBDHEX prodrug, and then the carboxyl-terminal NBDHEX prodrug is used to perform ligand exchange on superparamagnetic ferrite nanoparticles stabilized by oleic acid on the surface, so as to construct a functional layer of the NBDHEX prodrug on the surface of the nanoparticles. In this way, the drug NBDHEX interfering with the redox metabolism balance in cells and the superparamagnetic nanoparticles capable of inducing an active oxygen related effect are integrated into one, and the coupling degree of the superparamagnetic ferrite nanoparticles and the drug NBDHEX in the intracellular action process is enhanced. The disulfide bond connecting unit can be broken in a reducing environment to release NBDHEX and / or an active derivative thereof, the intervention of the nanoparticles on the intracellular redox homeostasis is enhanced, and the nanoparticles are beneficial to the application in antitumor treatment.

Methods of forming spinel ferrite nanoparticles containing a chromium-substituted copper ferrite as well as properties (e.g. particle size, crystallite size, pore size, surface area) of these spinel ferrite nanoparticles are described. Methods of preventing or reducing microbe growth on a surface by applying these spinel ferrite nanoparticles onto the surface in the form of a suspension or an antimicrobial product are also described.

This invention provides a magnetic metal oxide, its preparation method, and its application in tumor treatment, relating to the field of novel material preparation. The magnetic metal oxide comprises spinel-type ferrite nanoparticles of the general formula MFe₂O₄, wherein M is one or a combination of two of Mn, Co, and Zn. The magnetic metal oxide is obtained by calcining nano-MFE₂O₄ material in a reducing atmosphere and magnetizing it in a magnetic field, and exhibits a nanospherical structure. By improving magnetic properties without introducing additional functional components, the resulting magnetic metal oxide demonstrates enhanced thermal conversion efficiency in magnetothermal therapy, improved driving response capability in magnetically controlled nanorobots, and enhanced magnetic positioning performance in embolized microspheres, thereby better meeting its application requirements in the field of tumor treatment.