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Asymmetric magnetic mesoporous silica rod supporting chemotherapeutic and gene drugs and application thereof to tumor diagnosis and treatment

A silica rod and silica technology, which is used in gene therapy, drug combination, antitumor drugs, etc., to achieve good biocompatibility, improve therapeutic effect, and enhance the effect of nuclear magnetic imaging.

Inactive Publication Date: 2014-12-24
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the diagnosis and treatment of tumors is showing a trend of diversification, and the chemotherapeutic drugs and tumor multidrug resistance genes are co-loaded in a delivery body, and the drugs are released in an orderly and controlled manner, which integrates the diagnosis and treatment functions of magnetothermal and nuclear magnetic imaging. Not yet reported

Method used

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  • Asymmetric magnetic mesoporous silica rod supporting chemotherapeutic and gene drugs and application thereof to tumor diagnosis and treatment
  • Asymmetric magnetic mesoporous silica rod supporting chemotherapeutic and gene drugs and application thereof to tumor diagnosis and treatment
  • Asymmetric magnetic mesoporous silica rod supporting chemotherapeutic and gene drugs and application thereof to tumor diagnosis and treatment

Examples

Experimental program
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Effect test

Embodiment 1

[0040] (1) In 34mL diethylene glycol (DEG) solution, add 0.576g PAA and 0.13g FeCl 3 , stirred and heated to 250°C under the protection of nitrogen, after 20 minutes, 2.8mL of 80°C sodium hydroxide (NaOH) diethylene glycol solution (0.1g / mL) was added, and the reaction product was magnetically separated after stirring for 1 hour. Washed with water and dried to prepare spherical magnetic ferrite nanoparticles (Fe 3 o 4 ).

[0041] (2) Fe 3 o 4 Disperse in deionized water, add 50mg CTAB, add 0.5mL ammonia water after ultrasonication for 40 minutes, stir and heat to 40°C, slowly add 15uL TEOS dropwise, stir and react for 20 minutes; separate and purify the reaction product to obtain asymmetric magnetic mesoporous dioxide silicon rods. Disperse it in 100mL0.5% ammonium nitrate ethanol solution, stir and heat to reflux three times to remove CTAB. The obtained spherical magnetic ferrite nanoparticles have a diameter of 100nm, a mesoporous silica rod with a rod length of 200nm,...

Embodiment 2

[0046] (1) In 50mL diethylene glycol (DEG) solution, add 0.8g PAA and 0.2g FeCl 3 , stirred and heated to 250°C under the protection of nitrogen. After 20 minutes, 4.0mL of 80°C sodium hydroxide (NaOH) diethylene glycol solution (0.1g / mL) was added, stirred and reacted for 1 hour, and the reaction product was magnetically separated, washed with water, and dried to prepare spherical magnetic ferrite nanoparticles. Particles (Fe 3 o 4 ).

[0047] (2) Fe 3 o 4 Disperse in deionized water, add 50mg CTAB, add 1mL ammonia water after ultrasonication for 40 minutes, stir and heat to 40°C. 25uL TEOS was slowly added dropwise, and the reaction was stirred for 20 minutes; the reaction product was separated and purified to obtain asymmetric magnetic mesoporous silica rods. Disperse it in 100mL0.5% ammonium nitrate ethanol solution, stir and heat to reflux three times to remove CTAB. The obtained spherical magnetic ferrite nanoparticles have a diameter of 100nm, a mesoporous silica...

Embodiment 3

[0052] (1) In 50mL diethylene glycol (DEG) solution, add 0.6g PAA and 0.15g FeCl 3 , stirred and heated to 250°C under the protection of nitrogen. After 20 minutes, 3.0mL of 80°C sodium hydroxide (NaOH) diethylene glycol solution (0.1g / mL) was added, stirred and reacted for 1 hour, and the reaction product was magnetically separated, washed with water, and dried to prepare spherical magnetic ferrite nanoparticles. Particles (Fe 3 o 4 ).

[0053] (2) Fe 3 o 4 Disperse in deionized water, add 40mg CTAB, add 0.8mL ammonia water after ultrasonication for 40 minutes, stir and heat to 40°C. 50uL TEOS was slowly added dropwise, and the reaction was stirred for 20 minutes; the reaction product was separated and purified to obtain asymmetric magnetic mesoporous silica rods. Disperse it in 100mL0.5% ammonium nitrate ethanol solution, stir and heat to reflux three times to remove CTAB. The obtained spherical magnetic ferrite nanoparticles have a diameter of 100nm, a mesoporous sil...

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Abstract

The invention relates to the field of nanometer drug carriers, and concretely relates to an asymmetric magnetic mesoporous silica rod supporting chemotherapeutic and gene drugs and application thereof to tumor diagnosis and treatment. The asymmetric magnetic mesoporous silica rod is prepared by employing spherical magnetic ferrite nanoparticles and ethyl orthosilicate through a sol-gel method, and the asymmetric magnetic mesoporous silica rod is subjected to surface functionalization modification, and is successively loaded with a chemotherapeutic drug, coated by a positive high-molecular polymer and loaded with a gene drug, so that a target product is obtained. The chemotherapeutic drug is connected with the silica rod through functionalization of the mesoporous surface, and the silica rod is endowed with the pH-responsive drug release characteristic, also the biocompatibility of the composite material is increased and the in-vivo cycling time is prolonged, and gene is supported in an electrostatic adsorption mode. The composite material is injected into a living body via an intravenous route, the characteristics of nanoparticle in-vivo passive targeting, gene guiding and pH-responsive drug release of the composite material are utilized, also the cooperativity of the multidrug resistant gene and the chemotherapeutic drug is utilized, and in-vitro magnetic targeting, NMR imaging and other technologies are applied to diagnosis and treatment of malignant tumors.

Description

technical field [0001] The present invention relates to the field of nano drug carriers, in particular to an asymmetric magnetic mesoporous silica rod co-carrying chemotherapy and gene drugs and its application in tumor diagnosis and treatment. The asymmetric magnetic mesoporous silica rod has With high magnetic properties and high drug loading capacity, it can co-carry chemotherapy drugs and tumor multidrug resistance genes in one delivery body, and release drugs in an orderly and controlled manner, and integrates diagnosis and treatment functions such as magnetothermal and nuclear magnetic imaging. Background technique [0002] Malignant tumors have become the primary disease that seriously threatens human health. Tumor chemotherapy is one of the three main treatment methods, but its clinical application is gradually limited due to poor targeting and multidrug resistance. Traditional chemotherapy has poor targeting and severe side effects, and multidrug resistance of tumo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K47/02A61K47/24A61K48/00A61K45/00A61K49/08A61P35/00
Inventor 陈立董文飞李晶邵丹
Owner JILIN UNIV
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