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7 results about "Cooperativity" patented technology
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Cooperativity is a phenomenon displayed by systems involving identical or near-identical elements, which act dependently of each other, relative to a hypothetical standard non-interacting system in which the individual elements are acting independently. One manifestation of this is enzymes or receptors that have multiple binding sites where the affinity of the binding sites for a ligand is apparently increased, positive cooperativity, or decreased, negative cooperativity, upon the binding of a ligand to a binding site. For example, when an oxygen atom binds to one of hemoglobin's four binding sites, the affinity to oxygen of the three remaining available binding sites increases; i.e. oxygen is more likely to bind to a hemoglobin bound to one oxygen than to an unbound hemoglobin. This is referred to as cooperative binding.
Sensing base material for driving ordered distribution of dioxin in spatial confinement and preparation method of sensing base material
The invention discloses a sensing base material for driving ordered distribution of dioxin in a spatial confinement range and a preparation method thereof. The preparation method comprises the following steps: preparing an MOF matrix based on a binary mixed ligand, directionally regulating and controlling a vertical pore channel, hydrophobically modifying-CF3, and regulating and controlling competitive coordination doping. The invention provides a triple strategy of'mixed ligand + post-modification + defect control 'based on a synergistic effect of'gradient modification + vertical confinement'. Through the strategy, the performance is obviously improved in the adsorption application of a typical dioxin compound 2, 3, 7, 8-TCDD. Meanwhile, the material prepared by the invention can effectively drive ordered distribution of 2, 3, 7, 8-TCDD in a vertical pore channel, and provides a key basic material for stable SERS (Surface Enhanced Raman Scattering) sensing analysis.
Owner:INST OF QUALITY STANDARD & TESTING TECH FOR AGRO PROD OF CAAS
Allosteric modulators of inhibitory immune receptor complexes
PCT designated stageWO2026008664A1Immunoglobulins against cell receptors/antigens/surface-determinantsAutoimmune conditionAutoimmune disease
This disclosure relates to an immunoglobulin single variable domain (ISVD)-containing modulator that allosterically binds to a three-dimensional (3D) epitope of a protein complex comprising at least one inhibitory immune receptor and at least one corresponding ligand. The modulator regulates cooperativity within such complexes, thereby affecting the binding affinity and downstream signaling pathways. Specifically, the allosteric modulator of this invention induces positive cooperativity in immunoinhibitory receptor-ligand complexes, thus suppressing immune responses in a spatiotemporally restricted manner. Accordingly, these allosteric modulators are useful as therapeutic agents for inflammatory diseases, such as autoimmune diseases, allergic diseases, or graft-versus-host disease (GVHD). Moreover, this disclosure pertains to methods for identifying, selecting, and producing said allosteric modulators.
Owner:VLAAMS INTERUNIVERSITAIR INST VOOR BIOTECHNOLOGIE VZW +1
Modified Fc-regions to enhance functional affinity of antibodies and antigen binding fragments thereof
ActiveUS12595313B2Immunoglobulins against blood group antigensHybrid immunoglobulinsAntigen Binding FragmentAntigen binding
The present invention relates to the identification of key residues within mouse IgG3 antibodies (mAbs) that are responsible for intermolecular cooperativity and their transfer into IgG1 antibodies in order to enhance their functional affinity and direct a cell killing.
Owner:SCANCELL
Display of molecules on silently genetically encoded nanoscale carriers for determining synergistic molecular interactions
The present application provides a method of producing a “liquid” array of ligand (such as glycan) modified bacteriophage where the ligand modification is encoded genetically within the bacteriophage genome. This method will allow for the determination of the ligand binding profile of biomacromolecules and cells. Furthermore the method allows the elucidation of ligand-protein interactions where ligand binding is co-operative and synergistic.
Owner:48HOUR DISCOVERY INC
Modified Fc-regions to enhance functional affinity of antibodies and antigen binding fragments thereof
The present invention relates to the identification of key residues within mouse lgG3 antibodies (mAbs) that are responsible for intermolecular cooperativity and their transfer into lgG1 antibodies in order to enhance their functional affinity and direct cell killing.
Owner:SCANCELL
A method for identifying positive synergistic effect mixed insulation gas based on atomic charge distribution
PendingCN122177252AComputational theoretical chemistryComplex mathematical operationsChemical physicsElectronegativity
A method for identifying positive cooperating effects in mixed insulating gases based on atomic charge distribution is proposed. This invention addresses the problem that current methods for determining the type of cooperating effects in mixed gases require experimental basis, resulting in high costs and time consumption. A stable structure is constructed for gas molecules A and B, and their interaction configurations. The wave functions of the two gas molecules and the wave functions of the interaction configurations are calculated in relation to the Boltzmann distribution ratio. The electronegativity of the two gas molecules is calculated based on their wave functions. The corresponding atomic charge distributions are calculated based on the wave functions of the three molecules in a neutral state. A linear weighted value of the charge transfer amount of each interaction configuration is calculated based on the Boltzmann distribution ratio. The charge transfer direction is analyzed based on the electronegativity of the two gas molecules and the linear weighted value of each interaction configuration. If the interaction configuration exhibits a characteristic of electron transfer to the less electronegative gas molecule, it is a positive cooperating effect; otherwise, it is a cooperating effect.
Owner:HARBIN UNIV OF SCI & TECH
Anti-tumor composition and application thereof
PendingCN120754077AOrganic active ingredientsPharmaceutical non-active ingredientsPhosphorylationBinding site
The invention provides an anti-tumor composition and application thereof, and belongs to the technical field of biological medicine. The invention provides an anti-tumor composition. The anti-tumor composition comprises a first component and a second component, the first component is prepared from 2-hydroxycinnamic acid; the second component comprises ferulic acid and / or cinnamic acid; the molar ratio of the first component to the second component is (1-2): (1-3). In the composition disclosed by the invention, the 2-hydroxycinnamic acid and the cinnamic acid can target EGFR (Epidermal Growth Factor Receptor), and at an EGFR binding site, the 2-hydroxycinnamic acid and the cinnamic acid enhance the binding stability through hydrophobic interaction; 2-hydroxycinnamic acid and ferulic acid can target PCNA, and at a PCNA binding site, 2-hydroxycinnamic acid and ferulic acid achieve a synergistic effect through pi-pi stacking interaction. The anti-tumor composition provided by the invention can be used for targeted therapy of tumors with EGFRY845 phosphorylation and / or PCNA high expression characteristics.
Owner:TIANJIN TUMOR HOSPITAL