256 results about "A hemoglobin" patented technology

A method and apparatus for monitoring fluid balance status of a subject are disclosed. A hemoglobin measure indicative of hemoglobin concentration in the blood of a subject and at least one physiological parameter responsive to blood volume changes in the subject are determined and concurrent behavior of the hemoglobin measure and the at least one physiological parameter is indicated to a user, thereby to give an indication of fluid balance status of the subject. The cause and/or reliability of the fluid balance status may also be indicated.

A real-time simultaneous measurement apparatus includes: a hemoglobin information-receiving portion that sequentially receives hemoglobin information, which is information relating to the amount of hemoglobin in a head portion of a test subject, from a NIRS brain-measuring apparatus that receives a synchronization signal output by a synchronization signal output apparatus and acquires the hemoglobin information when the synchronization signal has been received; a brain wave information-receiving portion that sequentially receives the brain wave information of the test subject, from an EEG brain wave-measuring apparatus that receives a synchronization signal output by the synchronization signal output apparatus and acquires the brain wave information when the synchronization signal has been received; a synchronization processing portion that performs processing that synchronizes the hemoglobin information and the brain wave information; and an output portion that outputs the synchronized hemoglobin information and brain wave information.

An intelligent cerebrospinal fluid drainage control and recognition warning system mainly comprises a microcomputer system (1), a flow control device (2), an infrared drop number sensor (3), a color recognition sensor (4), a pressure sensor (5), a communication module (6), a human-computer interaction interface (7) and a radio frequency recognition device (13). The intelligent cerebrospinal fluid drainage control and recognition warning system can independently set the discharge speed, the drainage amount per unit time, the drainage time interval and the drainage pressure of cerebrospinal fluid according to individual differences of patients or clinical needs so as to achieve fixed-speed discharge, quantitative discharge, timed discharge and personalized-pressure discharge of the cerebrospinal fluid; meanwhile, in the drainage process, the color recognition sensor (4) can make timely prewarning when the cerebrospinal fluid has a hemoglobin reaction.

An apparatus noninvasively measures blood sugar concentration. The apparatus includes: a tissue modulation unit applying a pressure to a tissue; a hemoglobin (Hb) concentration measurement unit analyzing an amount of absorption of electromagnetic waves on a first portion of the tissue before and after the applying of the pressure by the tissue modulation unit, and measuring Hb concentration of the tissue; and a photoacoustic module unit analyzing photoacoustic signals to measure blood sugar concentration, and correcting the measured blood sugar concentration based on the measured Hb concentration to output a final blood sugar level, the photoacoustic signals being created from the tissue by emitting a pulse laser ray towards a second portion of the tissue before and after the applying of the pressure by the tissue modulation unit.

The invention provides a hemoglobin, hemoglobin-haptoglobin composite and transferrin joint examination kit. The hemoglobin, hemoglobin-haptoglobin composite and transferrin joint examination kit comprises an upper shell, a lower shell, an immunostrip, test paper and the like; a gold-labeled composite containing a hemoglobin monoclonal antibody, a hemoglobin-haptoglobin composite monoclonal antibody and a transferrin monoclonal antibody is scribed on a nitrocellulose membrane; 3 test lines, a quality control line (15) and a gold-labeled composite membrane scribing line (8) are arranged on the nitrocellulose membrane in parallel. The invention further provides a preparation method and a detection method of the hemoglobin, hemoglobin-haptoglobin composite and transferrin joint examination kit. The hemoglobin, hemoglobin-haptoglobin composite and transferrin joint examination kit is convenient and simple in operation, stable in performance and accurate in result, has a relatively good reference value for early diagnosis and identification of colorectal cancer or colon cancer tumor or other tumors with lower gastrointestinal bleeding symptoms in clinic, significantly improves the positive detection rate of digestive hemorrhagic diseases, is suitable for clinical hospital examination and household self-examination, and provides measures for large-scale general examination of such diseases.

A method of measuring a hemoglobin parameter of a test sample of blood comprises diluting and lysing a test sample. Then, a temperature corresponding to the test sample is obtained. The diluted and lysed test sample is then delivered to a cuvette, and a spectrophotometer determines the absorbance and/or transmittance of the sample in the cuvette. With the absorbance and/or transmittance of the test sample, a first measurement of the hemoglobin parameter of the test sample is obtained. After a first measurement of the hemoglobin parameter is obtained, a processor determines a corrected measurement of the hemoglobin parameter of the test sample. The corrected measurement is a function of the measured temperature that corresponds to the test sample and the first measurement of the hemoglobin parameter. The method of measuring a hemoglobin parameter is valid over a range of test sample temperatures.

The present invention provides a hemoglobin molecule (Hb) having six±one PEG chains, wherein two of said PEG chains are bound to Cys-93 (β) of Hb, and the remaining PEG chains are bound to thiol groups introduced on ε-NH₂ of Hb. The present invention also provides a process for preparing a modified hemoglobin molecule (Hb), comprising the steps of: (a) reacting Hb with 8-15 fold excess of iminothiolane to form thiolated Hb; and (b) reacting the thiolated Hb with 16-30 fold excess of PEG functionalized with a maleimide moiety, to form the modified Hb.

An endoscopic diagnosis system includes a white light source, a narrowband light source for emitting narrowband light having a given wavelength range of blue light, an image sensor receiving reflected light of white light and the narrowband light emitted with a given emission ratio to illuminate a subject from the subject to acquire a narrowband light image, and an image processor for calculating an enhanced luminance signal where a blue image signal of the narrowband light image is enhanced, calculating a hemoglobin index representing blood level in a medium to deep layer of a mucous membrane from a green image signal and a red image signal of the narrowband light image, calculating an enhanced color difference signal enhancing red according to a value of the hemoglobin index, and producing an image signal of an endoscopic image for display.

The invention discloses a method for preparing an enzyme electrode with an MWCNTs-TiO2/Nafion composite medium. In the method, MWCNTs-TiO2 core-shell nanocomposite materials are scattered into Nafion to prepare an organic-inorganic composite membrane as a fixed matrix for biological molecules for structuring a hemoglobin electrode, and a hemoglobin biosensor with fast response, high sensitivity and strong catalytic capacity is prepared by using the properties of large specific surface area, high surface reactivity, strong adsorption capacity, large electrical conductivity and the like of the MWCNTs-TiO2 core-shell nanocomposite materials and the properties of membrane forming, high chemical stability, high anti-interference capacity and the like of the Nafion. The biosensor has good biocompatibility, stability and repeatability, and has potential application in structuring biosensors. The sensor can be used for detecting the substances of hydrogen peroxide, trichloroacetic acid and the like, and has the advantages of low sensitivity, low detection limit and the like.

A method of measuring cellular hemoglobin of a blood sample includes mixing a blood sample with a permeation reagent, and incubating the sample mixture to permeate cellular membrane of red blood cells and to cause hemoglobin aggregation within the cells; adding a neutralization reagent to inhibit further reactions of the permeation reagent; performing a cell-by-cell measurement of side scatter signals of the red blood cells in the sample mixture on a flow cytometer; and obtaining cellular hemoglobin (Hgb_cell) of each red blood cell using the obtained side scatter signals. The method further includes measuring cellular hemoglobin of reticulocytes (Hgb_retic) by differentiating reticulocytes using a simultaneous fluorescence measurement. The method also includes measuring cellular percentage of a hemoglobin variant in mature red blood cells or reticulocytes by adding a fluorescent antibody in the neutralization reagent and detecting fluorescence signals of antibody bound hemoglobin variant.

The invention discloses a hemoglobin information based recognition method for multiple walking gait adjusting intents. The hemoglobin information based recognition method for the multiple walking gaitadjusting intents, disclosed by the invention, is characterized by comprising the steps: carrying out data preprocessing on cerebral cortex hemoglobin concentrations recorded at walking gait adjusting moments, wherein the cerebral cortex hemoglobin concentrations recorded at the walking gait adjusting moments are obtained in a manner that a testing experiment is performed by using a near infraredspectrum brain imaging technique (NIRS) and testees finish corresponding walking gait adjusting tasks in a fixed region; subjecting preprocessed cerebral cortex hemoglobin information to corresponding channeling according to distribution of cerebral functional areas, and calculating and extracting relevant parameters as characters; modeling a detection model for four kinds of gait adjusting intents by applying a pattern recognition algorithm. The method has the beneficial effect that the testing experiment is performed by using the near infrared spectrum brain imaging technique, and thus, themethod is simple and convenient.

The invention discloses a simple and reliable method, system and device for five-classification analysis of blood cells, including a white blood cell counting pool, a red blood cell and platelet counting pool, a five-classification detection device, a hemoglobin detection device, and a red blood cell detection device. The device divides blood samples and corresponding reagents into the two counting pools for reaction. It is characterized in that the system is equipped with two kinds of hemolysis agents, namely the first hemolysis agent and the second hemolysis agent, and the white blood cell four-category count and basophil The count is measured twice by the five-differential detection device, and the four-differential count and the total white blood cell count are realized by mixing the first hemolytic agent with the blood sample; the basophilic count is realized by mixing the second hemolytic agent with the blood sample added with diluent cell counts. The invention can realize low cost and small volume, and the accuracy of basophils can reach the level of high-end five-differentiation blood cell analyzer, which is more suitable for use in primary hospitals.

The invention discloses a construction method of an impedance type electrochemical sensor based on a molecularly imprinted polymer with a magnetic surface and an application of the sensor in protein detection, and belongs to the technical field of electrochemical sensing. The construction method comprises the following steps: synthesizing the molecularly imprinted polymer on the surface of a magnetic nano particle by taking hemoglobin as a template molecule and dopamine as a monomer and by using the self polymerization performance and the good adhesive capacity of the dopamine; eluting the hemoglobin, so as to prepare the molecularly imprinted polymer with the magnetic surface, wherein the molecularly imprinted polymer with the magnetic surface has the good identification effect on the hemoglobin; and fixing the polymer on the surface of a magnetic glassy carbon electrode under the action of a magnetic field, so as to construct a hemoglobin sensing interface based on the molecularly imprinted polymer with the magnetic surface, wherein the hemoglobin sensing interface based on the molecularly imprinted polymer with the magnetic surface is used for hemoglobin detection. The constructed electrochemical sensor based on the molecularly imprinted polymer with the magnetic surface is simple in method, high in hemoglobin detection sensitivity and good in selectivity.

It is to provide a method for measuring glycated hemoglobin in a hemoglobin-containing sample, comprising: reacting glycated hemoglobin in the hemoglobin-containing sample with a proteolytic enzyme in the presence of at least one salt selected from the group consisting of a pyridinium salt, a phosphonium salt, an imidazolium salt, and an isoquinolinium salt; reacting the obtained reaction product with fructosyl peptide oxidase; and measuring the generated hydrogen peroxide. The present invention provides a method for accurately measuring glycated hemoglobin in a hemoglobin-containing sample.

Disclosed is a compound which has a low molecular weight and has an activity of enhancing the production of EPO and/or an activity of enhancing the production of hemoglobin. Specifically disclosed is and EPO production enhancer and/or a hemoglobin production enhancer comprising a 1-acyl-4-(substituted oxy, substituted amino, or substituted thio)-1,2,3,4-tetrahydroquinoline derivative, more specifically a tetrahydroquinoline compound represented by general formula (1) [wherein R¹, R², R^2′, R³ and R^3′ independently represent a hydrogen atom, a C_1-6 alkyl group, or the like; R⁴, R⁵, R⁶, R⁷, R⁸, R⁹ and R¹⁰ independently represent a hydrogen atom, a halogen atom, a C_1-6 alkyl group, or the like; A represents N—R¹¹, a sulfur atom, or an oxygen atom; R¹¹ represents a hydrogen atom, a C_1-6 alkyl group, or the like; B represents a C_6-14 aryl group, or a 5- to 10-membered heterocyclic group; and n represents an integer of 0 or 1], a salt of the tetrahydroquinoline compound, or a solvate of the tetrahydroquinoline compound or the salt.

The present invention is directed to a bio-fluid detector such as a hemoglobin detector having the capability of receiving, storing and transmitting health information utilizing a portable transmitter and receiver including electronic PDAs such as cell phones. Further, the present invention utilizes a non-invasive hemoglobin detector that is connected to a portable transmitter-receiver such as PDAs including, but not limited to, cell phones.

The invention is applicable to the technical field of information processing, and provides a detecting method for a muscle fatigue level and equipment. The method includes the following steps: obtaining a biometric signal of a user; obtaining a wavelet amplitude mean value of a hemoglobin concentration signal through a preset wavelet averaging algorithm; performing Fourier transform on a surface myoelectric signal to obtain a surface myoelectric frequency domain curve of the surface myoelectric signal, and determining a median frequency value according to the surface myoelectric frequency domain curve; leading the wavelet amplitude mean value, median frequency value and a blood oxygen saturation concentration signal mean value into a preset fatigue level calculation model, and determininga current fatigue characteristic value of the user; and based on a preset fatigue level index table, determining the fatigue level corresponding to the fatigue characteristic value. According to the method, the active state of muscle fibers of current user muscles can be determined through the myoelectric signal, and the metabolic state of the muscles can be determined through the blood oxygen signal, so that a more comprehensive judgment on the muscle fatigue state is realized, and the detection accuracy of the muscle fatigue level is improved.

Disclosed is a functional NIRS imaging system including an elastomeric cap, a set of transmit optical fibers and a set of receive optical fibers terminating on the inside surface of the elastomeric cap. A pair of light sources combines to produce a collimated light beam at two wavelengths. An optical modulation system, converts the light beam into a plurality of probe light beams, modulates the plurality of probe light beams with a set of pseudo-orthogonal codes and directs each probe light beam into a transmit fiber. An optical detection system accepts scattered photons from subcutaneous tissue underneath the elastomeric cap as a plurality of collected light beams and converts them into a time series of electronic images, stores the electronic images into the memory and processes the electronic images using the pseudo-orthogonal codes. The system displays the resulting image on a display as a hemoglobin oxygen saturation map.

This invention relates to targeted delivery of anti-viral compounds through protein bioconjugation. More particularly, it relates to an anti-viral compound conjugated to a protein, such as hemoglobin and to a method of treating a viral infection using said conjugate. The invention also provides a method of targeted drug delivery of an anti-viral nucleoside analogue to macrophages, cells comprising a hemoglobin receptor and to CD163 bearing cells.

The present invention provides an optical measuring apparatus and an optical measuring method for being able to correct the influence of a superficial tissue to be able to accurately measure a degree of light absorption of a deep layer tissue such as a human body and fruits, and a storage medium that stores an optical measuring program. The optical measuring apparatus includes a probe, and the probe includes one light emitting diode and two photodiodes. In a configuration of the optical measuring apparatus, one of the photodiodes receives light which is emitted from the light emitting diode and transmitted through a superficial layer and a deep layer of a tissue, and the other photodiode receives light having a deep layer transmission distance different from that of the light received by one of the photodiodes. The light received by the other photodiode is also transmitted through the superficial layer and deep layer of the tissue. Based on intensity of the light received by each photodiode, a control unit computes a propagation constant in a medium through which the light propagates. An arithmetic expression is selected in accordance with an input fat thickness of the tissue, and an absorption coefficient of the light from a muscle tissue using the arithmetic expression based on the fat thickness and a spatial slope. A hemoglobin concentration and an oxygen saturation are obtained based on the obtained absorption coefficient of the light.

The invention discloses a hemoglobin dynamic spectrum analytical prediction method based on deep learning technology. Compared with the prior art, the defect that the hemoglobin concentration and thecorresponding disease thereof cannot be comprehensively analyzed in real time in batch is solved, the error caused by performing regression analysis is artificially avoided, and the accuracy of the measurement is increased. The method comprises the following steps: acquiring and preprocessing deep learning training data: constructing a deep learning model; acquiring deep learning testing data; inputting the preprocessed training data, the testing data and the corresponding labels into the deep learning model to accomplish the training and the evaluation on the deep learning model; inputting the to-be-tested data into the trained deep learning model to perform the prediction. The hemoglobin dynamic spectrum analytical prediction is performed based on a structure model of the ResNet, the prediction accuracy of the hemoglobin concentration and the robustness of the model are improved.