5 results about "Methemoglobin" patented technology

The present invention is an in vivo non-invasive method and apparatus for the measurement of the arterial blood oxygen saturation status of a patient, the method is a generalized improvement on conventional pulse oximetry to correct for its skin pigmentation bias and significant errors in oxygen saturation assessment in the presence of methemoglobin. The method requires an additional red light sensor with an infrared long pass filter to conventional pulse oximetry, and utilizes red and infrared light and sensors to non-invasively measure the peripheral pulse optical plethysmograph waveforms (PPG) at three light wavelengths, red, long pass red and infrared, positioned over a finger, or ear or other extremity, and from the pulse oximetric ratio of ratios transforms the PPG measurements by a processing device that determines the subject's arterial blood oxygen saturation directly, without the need for an empirical correction as is required in conventional pulse oximetry. The method determines the red transmitted light waveform and thus quantifies the wavelength shift from the incident red light due to the subject's skin pigmentation, and from in vivo hemoglobin extinction coefficients, determines the relative concentrations of oxygenated and deoxygenated hemoglobin and methemoglobin in the subject's arterial blood.

A modular patient monitor provides a multipurpose, scalable solution for various patient monitoring applications. In an embodiment, a modular patient monitor utilizes multiple wavelength optical sensor and / or acoustic sensor technologies to provide blood constituent monitoring and acoustic respiration monitoring (ARM) at its core, including pulse oximetry parameters and additional blood parameter measurements such as carboxyhemoglobin (HbCO) and methemoglobin (HbMet). Expansion modules provide blood pressure BP, blood glucose, ECG, CO2, depth of sedation and cerebral oximetry to name a few.Aspects of the present disclosure also include a transport dock for providing enhanced portability and functionally to handheld monitors. In an embodiment, the transport dock provides one or more docking interfaces for placing monitoring components in communication with other monitoring components. In an embodiment, the transport dock attaches to the modular patient monitor.

The application discloses a CRISPR-Cas12a-based PGM signal detection myoglobin biosensor and a preparation method thereof. The application also discloses a qualitative and quantitative in-vitro myoglobin detection method. The application can achieve naked-eye observation detection effect and realize qualitative analysis of experimental results. In combination with a blood glucose meter, the application can realize low-detection-limit detection, and the detection limit can reach 1.32 ng / mL. The application simultaneously detects a test strip and the blood glucose meter, is simple and convenient to install and carry, and is low in cost. The sensor has good selectivity, and the detection results of other proteins can be obviously distinguished from the myoglobin.

A sensor assembly enabling hemolysis detection with a diagnostic analyzer. The sensor assembly can be included in a diagnostic cartridge that may be coupled to the diagnostic analyzer and a sample fluid can be delivered thereto. The sensor assembly includes a main oxygen sensor configured to provide a first measurement and a modified oxygen sensor including an oxidant configured to oxidize hemoglobin iron to methemoglobin and configured to provide a second measurement. A hemolysis detection module of the diagnostic analyzer provides a level of hemolysis in the sample based on a difference between the first measurement and the second measurement. Numerous other diagnostic analyzers, diagnostic cartridges, and detection methods are provided.

A sensor assembly enables hemolysis detection by a diagnostic analyzer. The sensor assembly can be included in a diagnostic cartridge that can be coupled to the diagnostic analyzer and can deliver a sample fluid to the sensor assembly. The sensor assembly includes a primary oxygen sensor configured to provide a first measurement and a modified oxygen sensor including an oxidant configured to oxidize hemoglobin iron to methemoglobin and configured to provide a second measurement. A hemolysis detection module of the diagnostic analyzer provides the level of hemolysis in the sample based on the difference between the first measurement and the second measurement. Numerous other diagnostic analyzers, diagnostic cartridges, and detection methods are provided.