103 results about "Tumor excision" patented technology

The invention discloses a method for designing and forming a stiffness-controllable bone tumor defect repair implant. The method comprises the following steps of acquiring and preprocessing image data; performing reverse image fusion and registration, and constructing an accurate curve surface materialized repair body model; carrying out parallel finite element analysis and optimization on a porous design scheme by a microscopic porous scheme design; and importing the model into a 3D printing system for printing forming. According to the method, a personalized porous structure, mechanical optimization design and 3D printing forming of a post-bone tumor excision defect area reconstruction repair body are realized in combination with digital modeling, finite element analysis and medical 3D printing technologies according to a symmetric characteristic of a human body structure morphology, so that the reconstruction effect of an individualized anatomic morphology and the design forming efficiency of the repair body are improved, the time and material costs are reduced, the mechanical properties and the bone integration microenvironment after reconstruction are better optimized, and the bone growth repair of a bone defect area is facilitated.

The invention discloses a breast prosthesis manufacturing method based on the three-dimensional printing technology. The method comprises the steps that a tumor to be excised is analyzed and positioned according to breast medical image data of a patient before an operation, the shape, size and position of the excision part are determined, a three-dimensional digitalization tumor model is established, the radical treatment of the tumor and the demand for individualization overall beauty of the patient in the breast reestablishing process are comprehensively taken into consideration, a breast prosthesis three-dimensional model is optimized and designed according to the established tumor model and the breast shaping golden method, biologically-compatible materials conforming to the hand touch texture of the breast are selected, and the breast prosthesis is printed and formed through the biological three-dimensional printing technology. According to the breast prosthesis manufacturing method, the relation between the breast tumor and the peripheral tissue can be clearly displayed by analyzing and establishing the three-dimensional digitalization tumor model, and thus a doctor can conveniently determine the tumor excision range before the operation; the individualized accurate breast prosthesis can be provided for the patient quickly through the biological three-dimensional printing technology to improve the tumor radical treatment effect and the plastic surgery treatment effect, the living quality is improved, and the medical cost is lowered.

The present invention provides a minimally invasive, comprehensive same-day diagnosis and treatment method to remove tumor and ablate margins in breast cancer patients, comprising disease diagnosis by MRI and touch preparation cytology, followed by tumor removal and ablation of tumor margins.

The invention relates to the field of radiation oncology, specifically the use of novel radio-opaque fiduciary markers which resist migration within tissues, which may be implanted in the body and imaged during radio-therapy to insure accurate treatment of target regions while avoiding irradiation of non-target regions. In one embodiment, the markers comprise oblong bodies from which a plurality of short tines protrude. Also provided are novel devices for implanting such markers. Additionally, the invention provides methods of delineating tumor resection beds and whole-bladder contours in the radiotherapeutic treatment of bladder cancer. Lastly, the invention encompasses novel methods of delivering fiduciary markers and other implants and materials by needle with sealing aids that increase the retention rate of the delivered markers, implants, or materials.

The invention relates to an anti-hematocele tumor resection device, and belongs to the technical field of medical apparatuses. The anti-hematocele tumor resection device comprises a resection device charging disinfection box, a resection device storage layer, a resection device disinfection layer, a resection device hematocele recovery device and an electric operation panel, wherein a push-pull rod nested catheter is arranged at the upper side of the resection device charging disinfection box, a conveying push-pull rod is arranged at the upper side of the push-pull rod nested catheter, an instrument charging box is arranged at the lower side of the resection device charging disinfection box, and a charging battery is arranged in the instrument charging box. The anti-hematocele tumor resection device has the advantages that the functions are complete, and the convenience in use is realized; when a tumor is resected by a medical staff, the operation is simple and convenient, the time and labor are saved, and the working difficulty of the medical staff is decreased.

The invention discloses an operation robot system for performing laser resection and refrigeration on tumor tissues. The operation robot system comprises a computer system, a cryogenic system and an operation robot system, wherein an operation mechanical arm of the operation robot system is controlled by a computer mainframe to move freely; a cryogenic transmission tube of the cryogenic generator, laser fibers of a laser and a tail end image detector electrically connected with the computer mainframe extend into multiple arm sections sequentially and respectively to reach the tail end of the operation mechanical arm; cryogenic fluid is communicated with the cryogenic generator by virtue of a cryogenic solenoid valve; the tail end image detector is used for receiving relevant images and transmitting the relevant images to the computer mainframe by virtue of a data transmission line, and simultaneously, the relevant images are displayed on a display screen; the computer mainframe controls an operation robot mainframe and orders the movement, refrigeration and resection work in different directions of the operation mechanical arm; and as a doctor controls the mechanical arm to implement a whole operation in a non contact way, the tumor tissues are subjected to refrigeration and resection simultaneously, and the whole process is visualized, the precision and digitalization of the tumor resection are ensured, the risk of tumor spread is low, and the mechanical trauma is small.

The invention belongs to the field of chemistry and relates to an organic near-infrared two-photon fluorescent dye with a structure in a formula I in the specification. The organic near-infrared two-photon fluorescent dye has the beneficial effects that after being excited, the organic near-infrared two-photon fluorescent dye simultaneously shows stronger luminous efficiency of single-photon near-infrared fluorescence and two-photon fluorescence; the efficiency of two-photon fluorescence is obviously improved compared with that of other carbocyanine dyes; living cell fluorescence microscope experiments show that probes prepared from the fluorescent dye can enter tumor cell lysosome through endocytosis and can be imaged and simultaneously monitored by single-photon fluorescence and two-photon fluorescence microscopes; the dye can achieve synchronous single-photon near-infrared fluorescence and two-photon fluorescence imaging in the in-vivo and in-vitro states; and the fluorescent dye has the characteristics o good water solubility and stable chemical properties, can be used or bio-macromolecular markers and in the field of medical image diagnosis and especially has strong application value in optical image guided tumor excision.

The present invention discloses that an intratumoral injection of: i) glycolipids with α-gal epitope; ii) gene vectors comprising an α1,3galactosyltransferase gene; or iii) a mixture of α1,3galactosyltransferase, neuraminidase, and uridine diphosphate galactose results in tumor regression and / or destruction. Binding of the natural anti-Gal antibody to de novo expressed tumoral α-gal epitopes induces inflammation resulting in an anti-Gal antibody mediated opsonization of tumor cells and their uptake by antigen presenting cells. These antigen presenting cells migrate to draining lymph nodes and activate tumor specific T cells thereby converting the treated tumor lesions into in situ autologous tumor vaccines. This therapy can be applied to patients with multiple lesions and in neo-adjuvant therapy to patients before tumor resection. In addition to the regression and / or destruction of the treated tumor, such a vaccine will help in the immune mediated destruction of micrometastases that are not detectable during the removal of the treated tumor.

The invention discloses a new kind of nerve allotransplant, the preparation method and its medical application. The invention employs chemical extraction method to remove the schwann cell, axon and myelin sheath that can cause rejection for nerve allotransplant, stores stroma cell and three-dimensional pipeline structure for axon regeneration, and provides intact regenerative frame. The physical and biochemical property of nerve allotransplant are similar to that of normal nerve, and can be used as nerve allotransplant for damaged nerve.

The invention belongs to the technical field of medical instruments and relates to a minimally-invasive mammary gland tumor excision apparatus and a utilization method thereof. The minimally-invasive mammary gland tumor excision apparatus integrates excision and extraction devices used in a minimally invasive surgery. The apparatus comprises a sleeve and a gripping device operating rod and is characterized in that a sheet type gripping device and an excision device are arranged in the sleeve. In use of the apparatus, small-incision remote control can be realized, and a user can align the apparatus to a tumor in a body of a patient, control the gripping device operating rod to grip a to-be-excised part and extend a rotary tool holder at the same time to close at the bottom of the to-be-excised part, and finally rotate the operating rod to make the tool holder rotate for excising a tumor, wherein the excised tumor is retained in the gripping device and taken out of the body by the same. The minimally-invasive mammary gland tumor excision apparatus is small, flexible, simple in mounting and demounting, convenient to clean, small in external wound and available for small-incision remote control, surgery time is shortened, less bleeding is realized, and pains and physiological burden of the patient can be effectively alleviated.

A highly purified and heat stable cross-linked nonpolymeric tetrameric hemoglobin suitable for use in mammals without causing renal injury and vasoconstriction is provided. A high temperature and short time (HTST) heat processing step is performed to remove undesired dimeric form of hemoglobin, uncross-linked tetrameric hemoglobin, and plasma protein impurities effectively. Addition of N-acetyl cysteine after heat treatment and optionally before heat treatment maintains a low level of met-hemoglobin. The heat stable cross-linked tetrameric hemoglobin can improve and prolong oxygenation in normal and hypoxic tissue. In another aspect, the product is used in the treatment of various types of cancer such as leukemia, colorectal cancer, lung cancer, breast cancer, liver cancer, nasopharyngeal carcinoma and esophageal cancer. The inventive hemoglobin can also be used to prevent tumor metastasis and recurrence following surgical tumor excision. Further the inventive tetrameric hemoglobin can be administered to patients prior to chemotherapy and radiation treatment.

The invention relates to a method for preparing individually-customized pelvic tumor prosthesis. The method comprises the following steps of: reconstructing three-dimensional models of pelvises and tumors according to two-dimensional images of captive tests (CT), magnatic resonance imaging (MRI) and the like of patients before operations, demarcating a tumor excision boundary according to a tumor therapeutic principle, and determining a plane and an angle of pelvic osteotomy; and reconstructing the three-dimensional models of amputated pelvic defect parts by comparing with normal pelvises, designing and producing individually-customized prosthesis, and performing surface modification on a contacting section of a prosthesis material and bones to fulfill the aim of combining the prosthesis material and the bones stably. The pelvic tumor prosthesis designed by the method can be customized individually aiming at the tumor excision range of different patients to retain bone mass as far as possible while the tumors are excised completely, and can be matched with the original pelvic excision parts accurately to realize accurate pelvic reconstruction operations; bone integration is formed between the prosthesis and the bones to ensure the long-term stability of the prosthesis; and hip joints of the prosthesis are designed by super-radium acetabuli, so the prosthesis is stable and has a motion function.

The invention discloses application of histatin 1 (Hst1) polypeptide in preparation of composite materials for promoting repair of large-area skin defects. The Hst1 polypeptide is found to have the characteristics of promoting cell adhesion and vascularization and inhibiting inflammatory response. The Hst1 polypeptide can be loaded on a variety of biological materials, and can be prepared into dressing, injection, ointment, powder, hydrogel, membranes, sponges, fiber scaffold materials and the like, which can effectively promote the healing of the large-area skin defects, by being compounded with bioactive composite materials, wherein large-area skin defects include traumas, burns, skin ulcer caused by tumor resection or diabetes, and the like. The Hst1 polypeptide provided by the invention is human-derived polypeptide, and has good biocompatibility and biosafety. When being used for the preparation of the composite materials for promoting the repair of the large-area skin defects, theHst1 polypeptide has an important medical value and a good industrialization prospect.

The invention belongs to the technical field of medical apparatuses and instruments, and provides a self-locking type half kidney loop ligature for a minimally invasive surgery. The self-locking type half kidney loop ligature for the minimally invasive surgery is formed by a kidney ligature (1), a hoop (2), a connecting rod handle (3), a hoop clamping sheet (4), a self-locking pull sheet (5), a self-locking sliding block (6), a sliding block clamping sheet (7) and a movable handle (8). According to the self-locking type half kidney loop ligature for the minimally invasive surgery, by means of controlling the kidney ligature (1), only the blood supply of the kidney of a tumor growth end can be cut off, the effect of tumor removal is guaranteed, blood loss volume in the surgery process is reduced, and most importantly, the ischemia time of reserved parts of the kidney is reduced to zero; the fact that blocking on the blood supply of the whole kidney is avoided, the functions of the reserved parts of the kidney are protected to the maximum extent, and the significance of nephron-sparing surgeries under a peritoneoscope is fully embodied.

The invention relates to an assembly type artificial sacral prosthesis. The assembly type artificial sacral prosthesis comprises a prosthesis main body, a first sacral combination body and a second sacral combination body; the first sacral combination body and the second sacral combination body are connected with the prosthesis main body in a knocking and inserting manner; the first sacral combination body or the second sacral combination body comprises a connecting body and a bone setting body; each bone setting body is provided with a pore structure; and the first sacral combination body and / or the second sacral combination body is prepared by using a 3D printing technology. The assembly type artificial sacral prosthesis has the advantages that when the sacral bone is rebuilt, the assembly type artificial sacral prosthesis can be accurately matched with different excision faces of sacral tumors due to personalized customization, stress conduction recovery and stability of a lumbosacral portion are good, the length is conveniently adjusted so that the assembly type artificial sacral prosthesis is fixedly connected with the lumbar vertebra, the lumbar vertebra is prevented from hanging in the air and falling off, the assembly type artificial sacral prosthesis can be completely fused with the tumor excision faces, seamless joint is achieved, and long-term stability and recovery are good.

The invention belongs to the technical field of medical data detection, and particularly relates to a tumor detection method based on a Raman spectrum and a convolutional neural network. The inventiondiscloses a tumor detection method based on a Raman spectrum and a convolutional neural network. The tumor detection method comprises the following steps: S1, collecting and constructing a data set;s2, carrying out data set standardization processing; s3, carrying out data set amplification; s4, training a classification model; and s5, carrying out tumor prediction. The tumor detection method based on the Raman spectrum and the convolutional neural network is rapid, convenient and accurate, and aims to solve the technical problems that pathological biopsy steps of tumor tissue sections are numerous, long in time and general in accuracy in a tumor excision operation.

The invention discloses a photoacoustic imaging surgical navigation platform for guiding tumor excision, which comprises photoacoustic imaging equipment, and the photoacoustic imaging equipment comprises a main body, a probe and an image display. The invention discloses the photoacoustic imaging operation navigation platform for guiding tumor excision, and high-frame-rate photoacoustic images andultrasonic images can be provided; deep tissue tumors are visualized in real time; the position of the tumor can be positioned and a tumor boundary is accurately drawn; meanwhile, an aseptic scalpel can be visually improved through photoacoustic imaging; simultaneous development of the tumor and the scalpel under photoacoustic imaging is realized, and the focus can be thoroughly excised by directly viewing the tumor boundary without missing or mistaken cutting, the technology can be used for tumor positioning, boundary defining and accurate excision in the operation process, accurate intraoperative guidance is provided for tumor surgeons, the incompleteness of intraoperative tumor excision is reduced, the thorough excision rate is increased, normal tissue is reserved to the maximum extent,tumor recurrence is reduced, and the survival rate is increased.

The invention discloses artificial bones for recovering bone defects of osteoma. The artificial bones are prepared from polylactic acid powder (PLA), hydroxyapatite powder (HA) and dimethylbiguanide powder (MET) according to mass ratios of (8 to 10) to 1 to (3 to 5). According to the artificial bones disclosed by the invention, by using dimethylbiguanide as a main effect increasing component, the aims of suppressing tumor cells and enhancing bone recovering ability are fulfilled, and the defect that the bone defects of the osteoma easily and locally recur, in particular to benign or borderline tumors such as giant cell tumors of bones is overcome; and meanwhile, because of excellent bone recovery performance, the challenge that self-recovery of massive bone defects is difficult after tumor excision is performed can be solved.

The invention discloses a gynecological tumor removing device, and relates to the technical field of medical instruments. A first pincer leg is arranged on the left side of a second pincer leg, the upper end of the first pincer leg and the upper end of the second pincer leg are intersected, intersected portions are rotatably connected by a pin shaft, a first pincer nozzle is fixedly arranged at the upper end of the first pincer leg, a second pincer nozzle is fixedly arranged at the upper end of the second pincer leg, the first pincer leg and the first pincer nozzle are integrated, the second pincer leg and the second pincer nozzle are integrated, finger rings are arranged at the lower ends of the first pincer leg and the second pincer leg, the gynecological oncology removing device comprises a tumor cutting device and a tumor removing device, the tumor cutting device is fixedly arranged on the front side wall of the first pincer nozzle and can help medical staff to cut a tumor in a uterine cavity of a patient, surgical operation is more conveniently implemented, the medical staff does not need to manually enter the uterine cavity of the patient and grab the tumor in the uterine cavity, the length of an incision of the uterine cavity is reduced, and secondary harm to the patient is prevented.

A highly purified and heat stable cross-linked nonpolymeric tetrameric hemoglobin suitable for use in mammals without causing renal injury and vasoconstriction is provided. A high temperature and short time (HTST) heat processing step is performed to remove undesired dimeric form of hemoglobin, uncross-linked tetrameric hemoglobin, and plasma protein impurities effectively. Addition of N-acetyl cysteine after heat treatment and optionally before heat treatment maintains a low level of met-hemoglobin. The heat stable cross-linked tetrameric hemoglobin can improve and prolong oxygenation in normal and hypoxic tissue. In another aspect, the product is used in the treatment of various types of cancer such as leukemia, colorectal cancer, lung cancer, breast cancer, liver cancer, nasopharyngeal carcinoma and esophageal cancer. The inventive tetrameric hemoglobin can also be used to prevent tumor metastasis and recurrence following surgical tumor excision. Further the inventive tetrameric hemoglobin can be administered to patients prior to chemotherapy and radiation treatment.

The invention relates to a pair of multifunctional tumor stripping scissors. The pair of multifunctional tumor stripping scissors comprises scissor handles and scissor heads, wherein an exciting lightsource is arranged on one of the scissor handles; and the exciting light source can emit blue light which is 430-450nm in wavelength. The pair of multifunctional tumor stripping scissors further comprises stripping spoons which are rotatably connected to the ends of the scissor heads. The stripping spoons are connected to the ends of the scissor heads by virtue of micro rotating dampers. A catheter is arranged in the scissor handle; and one end of the catheter is connected to the scissor head, and an ultrasonic generator is connected to the other end of the catheter. A shadowless lamp is arranged on the scissor handle. A limiting connecting spring is arranged on the scissor handles. Finger rings are arranged at the ends of the scissor handles; and rubber rings are arranged on the inner walls of the finger rings. According to the device (the pair of scissors), a basis is provided for determining a tumor excision range through blue light radiation, so that the device is safe and convenient; the device, which can avoid three-dimensional radiography of a large fluorescence navigation system, is affordable; the device that the scissors and the stripping spoons are cooperated in use hasfunctions of scissoring and picking tumor tissues; and through 'hidden' design of the stripping spoons, the two functions are independent and are free from mutual influence, so that a storage area isdiminished. Meanwhile, the pair of scissors can also serve as an ultrasonic scalpel; therefore, the pair of scissors is broad in applicability.

A tumor excision device comprises a scissor body, a first fixing mechanism and a second fixing mechanism, the scissor body comprises a first scissor body and a second scissor body which are hinged, the first fixing mechanism comprises a first fixing block and a first sliding sleeve, and a first fixing groove is formed in the side face of the first fixing block; the first sliding sleeve is arranged in the first fixing groove through a reset spring and arranged on the outer side of the cutting-off part of the first cutter body in a sliding and sleeving mode. The second fixing mechanism comprises a second fixing block provided with a second fixing groove, and the cutting part of the second scissor body is arranged in the second fixing groove in a sliding mode through a second sliding sleeve. According to the tumor excision device, the first fixing block and the second fixing block are oppositely arranged, tumor tissue is clamped and fixed in the first step before the first scissor body makes contact with the second scissor body, a doctor can independently use a single instrument to complete surgical operation, the surgical space occupied by multiple instruments is saved, and the requirement of a minimally invasive surgery is met.

The invention discloses a surgical tumor operation real-time navigation method based on indocyanogen-green (Indocyanine-green for English abbreviation (ICG)) fluorescence development. The surgical tumor operation real-time navigation method comprises the following steps: 1, obtaining each frame of image in a real-time ICG fluorescence operation video and storing the image as an ICG fluorescence image; 2, segmenting a tumor boundary in the ICG fluorescence image by using a tumor boundary segmentation model based on deep learning, and adding the tumor boundary to the original ICG fluorescence image in a color line manner for display; 3, evaluating the segmentation boundary of the ICG fluorescence image by adopting an edge evaluation function to obtain a corresponding boundary clearness coefficient; and 4, finding out the image with the maximum boundary clearness coefficient, superposing the corresponding segmentation boundary on the tumor image under the conventional illumination, displaying a superposing result on a screen, and guiding a doctor to carry out a tumor excision operation.

The invention belongs to the field of pharmaceutic preparations, and relates to an antineoplastic agent containing hydrophobic chemotherapeutic drug nano-particles and fibrin glue. The antineoplastic agent can be a pharmaceutic preparation composed of hydrophobic chemotherapeutic drug nano-particles and fibrin glue, and can also be an oncotherapy agent prepared from a hydrophobic chemotherapeutic drug nano-particle preparation and a fibrin glue preparation right before use. The antineoplastic agent can be used for local drug delivery after tumor excision, and can make local drug concentration stay at a high level for a long time.

The invention discloses an irrigation and disinfection device used for tumor resection operation instruments. The irrigation and disinfection device comprises a disinfection box, a door panel, a storage board, a nozzle and a layering board; the layering board is horizontally arranged near the bottom end in the disinfection box; the surface of the layering board is provided with meshes; the upper surface of the layering board is horizontally provided with a support rod; one end of the support rod is fixedly connected with the inner side wall of the sterilization box, and the other end of the support rod is not in contact with the other side wall of the sterilization box and is welded to a limiting block; the inner wall of the end, close to the limiting block, of the disinfection box is rotationally provided with the door panel sealing an opening; the door panel is rotationally connected with the disinfection box; the two sides, adjacent to a fixture block, of the door panel are each fixedly connected with a second fixing rod; and the two sets of second fixing rods symmetrically distributed on the two sides of the door panel are rotationally connected with the inner wall of the disinfection box. The irrigation and disinfection device used for the tumor resection operation instruments has a reasonable structure, does not require manual disinfection and irrigation, ensures hygieneand tidiness, and can be widely used.

The invention provides a degradable photo-thermal / chemotherapy synergistic anti-tumor fiber dressing, and belongs to the technical field of biological medicines. Firstly, a polylactic acid-glycolic acid fiber membrane containing an anti-tumor drug adriamycin is prepared by an electrostatic spinning technology; the prepared composite fiber membrane is immersed into a dopamine-containing solution, and a polydopamine layer with a photo-thermal effect is formed on the surface of the fiber by utilizing dopamine self-polymerization reaction; and finally, the prepared composite fiber membrane is thoroughly cleaned and dried to prepare the degradable photo-thermal / chemotherapy synergistic anti-tumor fiber dressing. The fiber dressing disclosed by the invention has photo-thermal and chemotherapy dual anti-tumor effects at the same time, can realize large-area, long-acting and thorough killing of tumor cells of wounds after tumor excision, can be used for developing novel anti-tumor dressings, and is applied to clinical treatment.

The invention relates to a cardiology disease pathogeny detection device which comprises a plank bed, a transmitting probe, a receiving feedback device, a power supply device, and a control panel. A pillow platform, a first inductor, a second inductor and an emitter support are arranged on the upper side of the plank bed, a movable rising controller is arranged on the right side of the pillow platform, an induction bar is arranged on the first inductor, an emitter support rotating shaft and an emitter cross-bar are arranged on the emitter support, a hand-holding rotating machine is arranged on the emitter cross-bar, a display screen support fixed block is arranged on the upper left side of the plank bed, a display screen support is arranged on the display screen support fixed block, a display screen is arranged on the upper left side of the display screen support, landing legs are arranged on the lower side of the plank bed, and a rotator and a wheel cover are arranged on each landing leg. The cardiology disease pathogeny detection device has the advantages that the functions are complete, and the usage is convenient; when medical staff work on tumor resection, the operation is simple and convenient, time and effort are saved, and working difficulties of the medical staff are reduced.

The invention relates to the technical field of minimally invasive surgical equipment for breast tumors, in particular to a negative pressure suction type tumor excision device. The device comprises anegative pressure tube, a cover, a guide pin, a knife handle, a first spring, a limiting part and a knife head; a vertically downward suction opening is formed in the left end of the negative pressure tube, the cover fixedly sleeves the negative pressure tube, a space exists between the cover and the negative pressure tube; a guide long hole matched with the guide pin is arranged on the knife handle; the first spring sleeves the guide pin and is located between the cover and the knife handle; the limiting part comprises a rotary knob, a limiting shaft, a first limiting plate and a second limiting plate; the limiting shaft slidingly cooperates with a through hole formed in the cover; a bump is fixedly arranged outside the cover, and a groove matched with the second limiting plate is formedin the bump; the knife head is arranged between the negative pressure tube and the cover and comprises a knife holder and a knife blade, and the knife holder is fixedly connected with the left end ofthe knife handle. The negative pressure suction type tumor excision device is applicable to minimally invasive surgery, and the pain of patients during tumor excision can be relieved.