79 results about "Surgical excision" patented technology

This invention discloses a method and apparatus to deliver medical devices to targeted locations within human tissues using imaging data. The method enables the target location to be obtained from one imaging system, followed by the use of a second imaging system to verify the final position of the device. In particular, the invention discloses a method based on the initial identification of tissue targets using MR imaging, followed by the use of ultrasound imaging to verify and monitor accurate needle positioning. The invention can be used for acquiring biopsy samples to determine the grade and stage of cancer in various tissues including the brain, breast, abdomen, spine, liver, and kidney. The method is also useful for delivery of markers to a specific site to facilitate surgical removal of diseased tissue, or for the targeted delivery of applicators that destroy diseased tissues in-situ.

A method is disclosed for treating brain tissue with cryotreatment. A surgical tool, such as a catheter is disposed proximate to a target region of brain tissue. The tool or catheter provided includes a cryotreatment element. The cryotreatment element may be a cryochamber for enclosing the flow of a fluid refrigerant therein. The cryotreatment element is disposed at the situs of brain tissue to be treated, either through endovascular insertion, or via an opening in the cranium. A refrigerant flow within the cryochamber creates endothermic cooling with respect to the surrounding brain tissue, inducing hypothermia and forming iceballs proximate said tissue. The cooling may be reversible and non-permanent, or may be permanent leading to cell death, necrosis, apoptosis and/or surgical excision or ablation of tissue. Mapping using conventional techniques may be used to measure and assess brain function before and after cryotreatment, and cryotreatment itself may be integrally and progressively used to map brain function and treat tissue.

A method, using high intensity ultrasound, which may also be combined with a chemotherapy agent, that can result the direct destruction of tumor cells and in the reduction or elimination of local reoccurrence of cancer after removal of cancerous tissue, such as a surgical breast lumpectomy or surgical excision of a brain tumor. The method comprises either (1) the treatment of the tumor directly with High Intensity Focused Ultrasound, or (2) the treatment of the margins of the tissue surrounding the surgical cavity or void with ablative continuous wave high intensity ultrasound and a combination of a locally delivered chemotherapy agent and high intensity ultrasound, termed sonoporation. The present invention permits both the direct destruction (ablation) of tumor tissue as well as the destruction of tissue around the surgical margin and may include the enhanced local cellular uptake of locally injected chemotherapeutic drugs, all of which can be accomplished by a therapeutic ultrasound device used during surgery.

This device can be used to create new bone to fill a gap in the mandible after surgical excision. It uses a bone reconstruction plate as a distraction device. The reconstruction plate fixes the bone stumps on both sides of the bone gap. In the middle segment of the plate overlying the bone gap, the transport bone disc is carried on a transport unit that moves along a rail on the outer surface of the reconstruction plate.

Disclosed is a method for forming carbonated calcium hydroxyapatite. The disclosed method can be used for forming bone cements or optionally cast, cured scaffolds such as may be used in many medical applications, including as implants for bone damage caused by, for instance, trauma, disease, or surgical excision due to disease. The cured materials include an interconnected network including both microporosity and macroporosity. The disclosed materials can be very similar in both chemical and physical make-up to natural bone mineral. The invention is also directed to systems that can be used for conveniently carrying out the disclosed methods.

The present invention relates to a fluorescence navigation system used in tumor surgery, which belongs to clinical medicine surgery. The present invention solves problems existing in the surgical excision operation process of tumors that tumor boundaries are difficult to identify, remnant tumor tissue is difficult to recognize, and tumor metastasis lymph glands are difficult to track. The fluorescence navigation system used in tumor surgery is characterized in that the system comprises a biofluorescence excitation light source, a light guide system, a specificity targeted marking fluorescent material, a video camera and an image display and processing device connected with the video camera. The present invention provides fluorescence navigation concept for tumor surgery based on the prior art. When physicians identify tumor boundaries, recognize remnant tumor tissue, and track tumor metastasis lymph glands with a fluorescence observing mirror or a camera display system, tumor tissue is thoroughly excited, operation therapeutic effect is effectively improved, and the death rate of tumor patients is reduced. The present invention makes a breakthrough in tumor surgery.

A brachytherapy device including a spacing member is disclosed herein. The spacing member is useful in that the instrument is effective to limit the amount of radiation that comes into contact with the sensitive tissue, and thereby protect sensitive tissue from overheating or hotspots, and/or protect against radiation exposure outside of the patient's body which may affect healthcare providers or others who might come close to the patient. In particular, the spacing apparatus is effective to control the proximity of a brachytherapy device to the outer surface of the sensitive tissue proximate to a surgical excision site.

The invention discloses a personalized prosthesis and a making method and using method thereof. The making method comprises the steps of image acquisition, three-dimensional digital modeling, resin model establishment, computerized surgery simulation, model revalidation, internal fixation scheme making, prosthesis size formulation, personalized prosthesis parameter determination, prosthesis 3D printing and prosthesis cooling and cleaning. The personalized prosthesis obtained through 3D printing is especially suitable for spine, prosthesis design and simulation of reestablishment of a spine structure after excision can be conducted with a computer before operation, specific schemes can be made according to requirements of patients, and surgery precision and safety are improved.

The invention relates to a tumor grid organ model 3D printing method. The method particularly comprises the following steps: a cross section and a sagittal section when a human body is in a supine position are used for building crossed multiple grids on the surface of an organ, while the 3D grids are built, 3D modeling software specially adopted for original data for medical imaging (CT or MRI) picks out an organ or a tumor or a blood vessel in need of 3D printing, and building of 3D data is carried out. 3D data for the organ or the tumor or the blood vessel are built at the same time, and organ surface 3D grid data are built. The 3D data are inputted to a 3D printer for 3D model printing. According to the printed model of the invention, the tumor can be intuitively observed via a hollow organ shell and the distance between the tumor and the organ surface can be measured, a guide is provided for surgical resection, and a spatial distance between the tumor or the blood vessel inside the organ and an anatomical site on the organ surface can be directly read from the model.

A simulated tissue structure for surgical training is provided. The simulated tissue structure includes a first layer made of silicone and a second layer made of silicone interconnected by a third layer made of polyester fiber that is embedded in part in the first layer and in part in the second layer to create a mechanical linkage between the first layer and the second layer. Part of the third layer that is adjacent to the first layer and part of the third layer that is adjacent to the second layer includes fiber strands coated in silicone. An inclusion that mimics an anatomical structure is located between the first layer and the second layer. The third layer of polyester fibers provides a realistic dissection plane for the practice of the surgical excision of the inclusion.

A means for following the growth of experimental neoplasms involves administering recombinant tumor cells containing an expression construct encoding a secretable marker to an experimental animal and measuring secreted marker in the urine of animals bearing tumors formed by such recombinant tumor cells. Urinary marker levels are quantitatively related to tumor loads. Urinary marker can be detected before tumors are grossly visible or clinically apparent. Marker levels decrease following surgical excision or chemotherapeutic treatment, with an estimated half-life of 11 hours. This approach is applicable to the study of many experimental tumor systems.

The present invention is a device, system and method for surgical soft tissue lesion excision. The device is designed to be placed into a soft tissue lesion preferably under radiologic guidance and deployed. Once deployed, the shape memory wires of the soft tissue encompassing element form a wire cage surrounding the lesion which acts as an excision guide, encompassing and protecting the lesion during surgical excision of the lesion.

The invention discloses a culture method of oral squamous cell carcinoma organoid. The culture method comprises the following steps: S1, preparing a dissociation enzyme; S2, preparing a culture medium, wherein the culture medium is composed of a basal culture medium DMEM/F12, an R-spondin1 conditional culture medium, a Wnt3A conditional culture medium, sterile water and functional components; S3, obtaining a sample through clinical operation, namely obtaining a tumor specimen through material taking or surgical resection, cutting tissue, washing the tissue with sterile normal saline for three times, soaking the tissue in a DMEM medium for 1 hour and continuing to dissociate; S4, tissue pretreatment, namely placing the sample obtained in the step S3 in a sterile 6-well plate, and cutting up sample tissue blocks by using a disposable sterile surgical blade; S5, tissue dissociation and digestion, namely adding the dissociation enzyme prepared in the step S1, repeating the process of centrifugation-supernatant removal for three times so as to fully remove the dissociation enzyme, and mixing the cells with the sample tissue blocks before the last time of centrifugation; and S6, carrying out organoid culture.

The application relates to an intervertebral prothesis. In particular, to an articulating intervertebral disc prothesis. In use, the intervertebral prosthesis is fixed to the end plates of vertebrae following the surgical excision of a degenerative or ruptured disc. The intervertebral prothesis has substantially flat bone engaging surfaces with a macro-textured surface.

The invention relates to a pharmaceutical composition for treating pediatric adenoidal hypertrophy. The pharmaceutical composition comprises the following components in parts by weight: small centipeda herb, fructus gleditsiae, licorice root, orange peel, perilla, honeysuckle, sesame oil, cocklebur fruit, ligusticum wallichii, coptis root, chrysanthemum and peppermint. The pharmaceutical composition is prepared by crushing, stirring and decocting the components, and can be used for treating pediatric adenoidal hypertrophy which is treated without any special medicine except by surgical excision, even if a medicine is administered, the medicine is used for treating rhinitis or tonsils. The pharmaceutical composition provided by the invention is specially developed for adenoids, has a directeffect by dripping from nasal cavity and fills a gap in this field.

The invention belongs to the technical field of biological materials and particularly relates to a near-infrared second window emitted micro-molecular rear earth complex fluorescence probe and a preparation method thereof. The near-infrared second window emitted micro-molecular rear earth complex fluorescence probe comprises a complex coordinated by DOTA (1, 4, 7, 10-tetraazacyclododecan-1, 4, 7,10-tetraacetic acid) and rear earth Ln(III) metal, a complex coordinated by DOTA-NHS (DOTA-n-hydroxysuccinimide) ester and rear earth Ln(III) metal, and a reaction product of Ln-DOTA-NHS and amino-PEG(polyethylene glycol)-folic acid. By changing the functional groups in macrocyclic polyamine structures without affecting the coordinating ability of macrocyclic polyamines and rear earth ions, the near-infrared second window emitted micro-molecular rear earth complex fluorescence probe achieves tumor targeting effects after being specifically combined with tumor surface receptors and meanwhile achieves surgical excision of under the guidance of a near-infrared window. According to the variety of receptors to be modified by the micro-molecular rear earth complex fluorescence probe, the micro-molecular rear earth complex fluorescence probe can specifically target various tumors to achieve antibody-antigen immunoreaction, and through pairing of base pairs of DNA (deoxyribonucleic acid) sequences, to achieve gene expression.

The invention relates to the field of biopharmacy, in particular to semi-natural nanometer vesicae, a preparation method and application in preparing drugs for treating liver diseases. The invention discloses the semi-natural nanometer vesicae, the preparation method and the application in preparing the drugs for treating the liver diseases. The preparation method of the semi-natural nanometer vesicae is provided. Through pharmacology experiments, it is shown that the semi-natural nanometer vesicae have the effects of treating the acute and chronic liver diseases and liver damage caused by theacute and chronic liver diseases, and have a value of developing the drugs for treating the acute and chronic liver diseases and liver damage caused by the acute and chronic liver diseases. The semi-natural nanometer vesicae further have the effect of promoting regeneration and repair of part of the liver subjected to excision, and have the value of developing drugs for promoting regeneration ofthe liver which is subjected to surgical excision.

The invention provides a minimally invasive surgical positioning system. An endoscope is used for monitoring a surgical region; a marking positioning structure includes an A group calibration member and a positioning needle portion which have a fixed relative position relation; the positioning needle portion is used for entering the surgical region, and selecting a surgical part under the monitoring action of the endoscope; the A group calibration member is positioned outside a human body; a B group calibration member is fixed on a surgical mechanical arm; a three-dimensional space positioningdevice is used for acquiring spatial positions of the A group calibration member and the B group calibration member, and forming a three-dimensional relative position relation between the A group calibration member and the B group calibration member; and the control device is used for determining a three-dimensional relative relation between the surgical part selected by the positioning needle portion and the B group calibration member according to the three-dimensional relative position relation between the A group calibration member and the B group calibration member and the relative position relation between the A group calibration member and the positioning needle portion, and accordingly controlling the surgical mechanical arm to move to the surgical part. The minimally invasive surgical positioning system is accurate in positioning.