Applications of hifu and chemotherapy

A high-intensity, ultrasonic technology, applied in the direction of ultrasonic therapy, application, ultrasonic introduction, etc., can solve the problems of low, already displayed, etc.

Inactive Publication Date: 2007-04-18
UST INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although sonoporation was found to be less efficient in transport in vitro and in vivo, it has been shown to be as effective as electroporation in inducing drug uptake into cells

Method used

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  • Applications of hifu and chemotherapy
  • Applications of hifu and chemotherapy
  • Applications of hifu and chemotherapy

Examples

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Embodiment Construction

[0025] While the details of the invention are discussed with reference to the detailed description, the accompanying drawings show the invention by way of example only.

[0026] The present invention includes a surgical probe that emits ultrasound that uniformly and directly cauterizes (or heats to destroy) tumor tissue when delivering high-intensity ultrasound, and that produces indirect effects by increasing the cellular uptake of chemotherapeutic drugs when delivering low-intensity ultrasound. The present invention also includes the use of high-intensity ultrasound alone or in combination with sonoporation to locally deliver chemotherapy drugs to the area surrounding surgical procedures such as breast lumpectomy or brain tumors, thereby potentially eliminating tumor cells that are harmful to the surgical margins. The resulting need for a "second lumpectomy" potentially eliminates post-lumpectomy radiation therapy and reduces or eliminates residual tumor at the margins of the...

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Abstract

A method, using high intensity ultrasound, which may also be combined with a chemotherapy agent, that can result the direct destruction of tumor cells and in the reduction or elimination of local reoccurrence of cancer after removal of cancerous tissue, such as a surgical breast lumpectomy or surgical excision of a brain tumor. The method comprises either (1) the treatment of the tumor directly with High Intensity Focused Ultrasound, or (2) the treatment of the margins of the tissue surrounding the surgical cavity or void with ablative continuous wave high intensity ultrasound and a combination of a locally delivered chemotherapy agent and high intensity ultrasound, termed sonoporation. The present invention permits both the direct destruction (ablation) of tumor tissue as well as the destruction of tissue around the surgical margin and may include the enhanced local cellular uptake of locally injected chemotherapeutic drugs, all of which can be accomplished by a therapeutic ultrasound device used during surgery.

Description

[0001] This application claims priority to US Provisional Patent Application Serial No. 60 / 726,254, filed October 13, 2005, the entire contents of which are hereby incorporated by reference. field of invention [0002] The present invention describes a device and method for treating tumors and surrounding tissue margins with high intensity focused ultrasound (HIFU) and chemotherapy. The therapy combines the ability of HIFU to induce coagulation necrosis with the synergistic effects of ultrasound and chemotherapy and is often described as sonoporation. This method is used to treat tumors and / or the margins around tumors to prevent local recurrence of cancer due to residual cancer cells in adjacent or nearby tissues. Background of the invention [0003] Improved imaging techniques and the use of early repeat mammography have enabled many breast cancers to be diagnosed when tumors are 1 cm or smaller in diameter, or confined to breast ducts. The first-choice treatment for thes...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B17/00A61B17/32A61B18/00A61N7/02A61N7/00A61M5/00
CPCA61N7/02A61B8/4438A61N2007/0078A61B2018/00005A61N7/022A61K41/0047A61B2017/00482
Inventor E·A·拉森P·W·卡敏斯基
Owner UST INC
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