The invention relates to an intracranial tumor comprehensive operation planning and simulating method based on the 3D print technology. DICOM data obtained through patient spiral CT craniocerebral enhancement scanning are utilized first, different partition methods are adopted for data information extraction and reconstruction according to characteristics of skulls, blood vessels and tumors, and registration and fusion of the skulls, the blood vessels and the tumors are achieved in the same coordinate system; craniocerebral entity models of patients are obtained through a rapid prototyping technology and a virtual three-dimensional geometrical model after optimizing processing is conducted; information of diameters, sizes and the number of tumors and adjacent relations between the diameters, the sizes and the number of tumors and important blood vessels and tissue around is extracted, and preoperative comprehensive risk analysis, operation plan design, operation plan simulation and operation risk response analysis are carried out on the basis of the craniocerebral entity models of the patients, personalized operation plans are provided for the patients in order to improve the accuracy and success rate of intracranial tumor excision operations, and a feasible intracranial tumor operation planning and simulating method based on the 3D print technology is explored.