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474 results about "Pulmonary nodule" patented technology

Intelligent grading method and system for pulmonary nodules based on multi-modal feature fusion

Provided is an intelligent grading method and system for pulmonary nodules based on multi-modal feature fusion, including: obtaining ROI and VOI of pulmonary nodules based on chest CT examination images and examination reports by utilizing clinical multi-modal data from physical examination population, designing a multi-task feature extraction network based on attention mechanism, to obtain radiomics features and deep image features from the ROI and VOI; designing a cross-modal feature fusion method based on graph representation learning, designing a multi-modal information extraction method, obtaining specific feature representations and graph structures of modalities, and then fusing the feature representations and the graph structures; and proposing an optimization and clinical verification method of pulmonary nodule grading GCN model based on self-supervised learning, to realize fine grading of pulmonary nodule malignancy with slight differences, thereby providing a new approach to design of fine-grained classification algorithms.
Owner:ZHENGZHOU UNIV

Method and system for detecting miniature focus of pulmonary tuberculosis based on multi-scale convolution

PendingCN120107251AImage enhancementImage analysisPulmonary noduleLung tuberculosis
The invention discloses a pulmonary tuberculosis micro focus detection method and system based on multi-scale convolution. The method comprises the following steps: acquiring lung CT image data; the method comprises the following steps: performing feature extraction through a convolutional layer of a neural network detection model of a pulmonary nodule focus, inputting an extracted feature map into a Faster and efficient multi-scale attention fusion module, and then inputting outputs of different levels in a feature pyramid in a backbone network into a corresponding ADown module, a Conv module and an UpSample module in a multi-scale convolution module; and multiple pieces of feature information are obtained through multi-scale convolution, a prediction frame is finally generated, and a detection result is obtained. A YOLOv10 model framework is improved, the feature extraction performance is improved by using a C2f-Faster-EMA module, a multi-scale convolution module is added into a feature fusion network to process features of different scales, cross-multi-scale context feature information is captured, multiple pieces of feature information are obtained, and the information interaction capability is improved.
Owner:CHANGSHU INSTITUTE OF TECHNOLOGY

Lung CT image segmentation method based on Transform and U-Net

The invention discloses a lung CT image segmentation method based on Transform and U-Net, and the method comprises the steps: firstly obtaining a pulmonary nodule CT scanning image, carrying out the preprocessing, then constructing a segmentation model MCSTU-Net, enabling the model to extract abundant features through the fusion of a convolutional neural network and a Swin Transform module, and enabling the segmentation model to obtain a segmentation model MCSTU-Net. Enhancing and fusing feature information from different levels through a multiple attention fusion module; dividing the data set into a training set, a test set and a verification set, training and verifying the segmentation model, and finally performing focus segmentation on the pulmonary nodule CT scanning image by using the trained and verified model. According to the model and the method constructed by the invention, lesion tissues in the lung CT image can be segmented more accurately, the effectiveness of each module is verified through an ablation experiment, and doctors are assisted to diagnose and treat lung diseases.
Owner:HANGZHOU NORMAL UNIVERSITY

Pulmonary nodule segmentation method and system based on diffusion model

The invention belongs to the technical field of medical treatment, and discloses a pulmonary nodule segmentation method and system based on a diffusion model, and the method employs a potential space fusion method based on anatomical constraint, integrates the anatomical priori knowledge of lung tissue contour and the like through a variational auto-encoder (VAE), and combines a KL divergence constraint strategy. And the sensitivity of the model to a tiny focus is effectively improved. Secondly, a multi-modal collaborative optimization FSUNet architecture is constructed, and a cross-scale feature pyramid fusion mechanism is utilized to cooperate with a channel attention gating and dynamic noise scheduling algorithm, so that the expression ability of multi-dimensional features is enhanced. And finally, designing a Dice-Focal joint loss function to suppress complex background noise interference, and meanwhile, based on a forward diffusion-based noise sample generation strategy, remarkably reducing the dependence of the model on annotated data. Experimental results on an LIDC-IDRI data set show that the diffusion segmentation method based on multi-scale feature fusion not only shows excellent performance, but also shows excellent performance on an FPS index at the same time.
Owner:HAINAN UNIV

Pulmonary nodule malignant risk dynamic prediction method and system based on space-time attention and multi-modal data guide fusion

The invention relates to the technical field of medical artificial intelligence, in particular to a pulmonary nodule malignant risk dynamic prediction method and system based on space-time attention and multi-modal data guide fusion. Clinical features are obtained based on clinical data, and a lung CT slice image is obtained based on a lung CT image; the method comprises the following steps: extracting general medical visual features in an image by using an open-source medical large model, extracting image features in a lung CT slice image through a visual Transform model, and performing feature guide optimization on the image features based on clinical features and the general medical visual features to obtain patient image specific features; performing joint mapping on the specific features of the patient image by using a space-time attention mechanism to obtain space-time enhancement features of the patient image; and performing weighted fusion on the clinical features, the general medical visual features and the space-time enhancement features of the patient by using a gating mechanism, and obtaining the risk prediction probability of the malignant pulmonary nodules of the patient by using a classifier. The method can predict the malignant probability of the pulmonary nodule, and facilitates the realization of auxiliary diagnosis such as pulmonary nodule screening.
Owner:Chinese People's Liberation Army Cyberspace Force Information Engineering University

Pulmonary nodule boundary detection method based on semantic segmentation

The invention discloses a pulmonary nodule boundary detection method based on semantic segmentation. The method comprises the following steps: generating an edge prior image set; obtaining a multi-scale boundary alignment feature map set and a deformation offset parameter set; a post-gating deformation offset parameter set is obtained, the multi-scale boundary alignment feature image set is updated, cross-scale feature fusion is executed, and a fusion feature image set is generated; establishing a node set and an edge set by utilizing node features in the fusion feature graph set and a spatial adjacency relationship, and initializing a node feature vector set; forming a fusion feature map set enhanced by multi-hop reasoning; and outputting a pulmonary nodule region mask prediction image set and a pulmonary nodule boundary probability prediction image set. According to the method, fracture between pseudo boundaries and slices is effectively inhibited, so that a three-dimensional structure prediction result is more coherent, and high-readability and high-consistency boundary segmentation output is provided for a clinical CAD (Computer Aided Design) system.
Owner:HUNAN UNIV OF SCI & ENG

Pulmonary nodule risk prediction method, system and device based on large model and medium

The invention discloses a pulmonary nodule risk prediction method, system and device based on a large model, and a medium, belongs to the technical field of artificial intelligence, and aims to solve the technical problems of insufficient generalization ability of a network model and poor pulmonary nodule multi-task prediction effect in the prior art. The method comprises the following steps: acquiring sample data of multiple modalities including medical images, gene detection and demographic data; single-mode features are obtained through an exclusive feature extraction module, and then the single-mode features are input into a plurality of expert networks to obtain single-mode experts; obtaining a multi-modal feature after the single-modal feature passes through a cross-modal attention module, and inputting the multi-modal feature into a plurality of expert networks to obtain a plurality of multi-modal experts; the three task MoE modules are all provided with task gating networks in a matched mode, and the task MoE modules select the most appropriate expert set according to the calculated probability that each expert is activated; acquiring to-be-predicted data, inputting the to-be-predicted data into the selected expert set, and outputting malignant, growth and wettability risk prediction results of the pulmonary nodules by the task model.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV

Deep learning model system for benign and malignant diagnosis of solid pulmonary nodules

The invention belongs to the technical field of benign and malignant diagnosis model systems for solid pulmonary nodules, and particularly relates to a benign and malignant diagnosis deep learning model system for solid pulmonary nodules. Comprising an overall architecture system of the model, a data set introduction system, a data set preprocessing system, a lung CT image segmentation system, a lung nodule detection system, a lung nodule category system, an experiment parameter setting system, an evaluation index system and an experiment setting and result system. A lower half branch of the network is mainly designed, the lower half branch network extracts multi-scale feature information of a lung CT image through an Inception module, and convolutional attention modules such as ECA and CBAM are introduced to enhance the extraction effect of the lower half branch network on position and shape features of the lung CT image.
Owner:SHANGHAI CHANGHAI HOSPITAL +2

Pulmonary nodule display method and device, electronic equipment and storage medium

The invention provides a pulmonary nodule display method and device, electronic equipment and a storage medium, and the method comprises the steps: segmenting a three-dimensional reconstruction image of the chest of a target patient to obtain a preoperative segmentation image, the three-dimensional reconstruction image being obtained based on preoperative CT data, and the preoperative segmentation image comprising the position information of a pulmonary nodule; segmenting the video image of the intraoperative lung tissue of the target patient collected by the thoracoscope in real time to obtain an intraoperative segmented image; feature matching is conducted on the preoperative segmented image and the intra-operative segmented image, the lens pose of the thoracoscope is determined, the preoperative segmented image is mapped into a two-dimensional reference image based on the lens pose, and the two-dimensional reference image comprises the position information of the pulmonary nodule; and carrying out image registration on the two-dimensional reference image and the intra-operative segmented image, and carrying out pulmonary nodule marking on the intra-operative segmented image to obtain a video image for displaying pulmonary nodules in real time. The position of the pulmonary nodule in the operation is accurately displayed in real time in a non-invasive mode, and the operation efficiency is improved.
Owner:PEKING UNION MEDICAL COLLEGE HOSPITAL

Minimally invasive puncture biopsy excision device for pulmonary nodules

The invention relates to a pulmonary nodule minimally invasive needle biopsy excision device, and relates to the technical field of medical instruments. The system comprises a mechanical arm electrically connected with CT equipment, navigation auxiliary equipment, a puncture assembly detachably connected with the mechanical arm and used for puncturing human tissue, a sampling assembly for sampling tissue at a nodule and a marking assembly for marking the sampling position; the puncture assembly comprises a mounting base detachably connected with the mechanical arm and a puncture needle arranged on the mounting base, and the end of the puncture needle is sharp. The puncture needle is arranged in a hollow mode, the sampling assembly comprises a rotary cutting cylinder rotationally arranged in the puncture needle and a power part for driving the rotary cutting cylinder to rotate, a first rotary cutting opening is formed in the puncture needle, a second rotary cutting opening is formed in the rotary cutting cylinder, and the first rotary cutting opening movably corresponds to the second rotary cutting opening. The biopsy sampling device has the advantages that the sampling amount of each biopsy sampling is conveniently increased, the puncture sampling frequency is reduced, and meanwhile the radiation dosage is reduced.
Owner:GOLDBOV PHOTOELECTRONICS

Computer-aided diagnosis system for pulmonary nodule analysis using PCCT images

Systems and methods for performing one or more medical imaging analysis tasks on PCCT (photon-counting computed tomography) images are provided. Image acquisition parameters of a PCCT image acquisition device are determined for acquiring PCCT images. One or more PCCT images of an anatomical object of a patient acquired using the PCCT image acquisition device configured with the image acquisition parameters are received. One or more medical imaging analysis tasks analyzing the anatomical object are performed based on the one or more PCCT images using one or more machine learning based models. Results of the one or more medical imaging analysis tasks are output.
Owner:SIEMENS HEALTHINEERS AG

Three-dimensional pulmonary nodule detection method and system based on morphological adaptation convolution

The invention discloses a three-dimensional pulmonary nodule detection method and system based on morphological adaptation convolution, and the method comprises the steps: obtaining a chest CT image sequence, and carrying out the preprocessing of all chest CT images in the chest CT image sequence; according to the three-dimensional pulmonary nodule detection method and system based on form adaptive convolution, scale factors are introduced into a 3D dynamic convolution layer and cooperate with the offset, so that the position of a convolution kernel sampling point can be adaptively adjusted according to the form and size of the pulmonary nodule, and the problem that the traditional fixed convolution is difficult to adapt to the size difference and form heterogeneity of the pulmonary nodule is solved; stable detection of pulmonary nodules with different sizes, especially tiny pulmonary nodules, is realized; space coordinate information and multi-scale features are combined through a channel space attention module, extraction of key information such as pulmonary nodule edge texture and density gradient is enhanced, interference of blood vessel, trachea and CT artifacts is inhibited, and the problem that small nodules and background noise are difficult to distinguish is solved.
Owner:ZHEJIANG UNIV OF TECH

Pulmonary nodule image segmentation method and device based on optimized downsampling and feature fusion

The invention discloses a pulmonary nodule image segmentation method and device based on optimization down-sampling and feature fusion, and relates to the technical field of image processing, the method comprises the steps: obtaining a data set containing a plurality of chest CT images, cutting the chest CT images in the data set into a preset-size region of interest containing pulmonary nodules, and obtaining a plurality of pulmonary nodules; constructing to obtain a training set, a verification set and a test set; the method comprises the following steps: constructing an SPDD module for realizing space-to-depth downsampling and a DPFM module for realizing dual-branch fusion, and creating a DFNet model based on the constructed SPDD module and DPFM module; and training, verifying and testing the DFNet model based on the training set, the verification set and the test set, and evaluating the performance of the DFNet model. The pulmonary nodule segmentation capability of the model can be effectively improved.
Owner:SOUTH CENTRAL UNIVERSITY FOR NATIONALITIES

Genetic signature of lung cancer

PCT designated stage expiredWO2025078639A1Microbiological testing/measurementPulmonary noduleOncology
The present invention relates to a method which allows for determining if the lung nodules of a patient are benign or cancerous. Furthermore the method also allows to determine if a patient is at high risk of developing lung cancer and if it should be subject to medical intervention.
Owner:PANGAEA ONCOLOGY SA

Lung-cancer screening model construction apparatus, lung-cancer screening apparatus, and device and medium

PCT designated stage expiredWO2025081714A1Medical simulationEpidemiological alert systemsPulmonary noduleNewly diagnosed
The present application relates to a lung-cancer screening model construction apparatus, a lung-cancer screening apparatus, and a device and a medium. The lung-cancer screening model construction apparatus comprises: a sample acquisition and data collection module, which is used for acquiring benign pulmonary nodule patient samples, and collecting baseline parameters of the benign pulmonary nodule patient samples, wherein the baseline parameters comprise radial growths of pulmonary nodules and serum thymidine kinase 1; a model training module, which is used for performing model training by using the baseline parameters as independent variables and using, as dependent variables, risks of lung cancer newly diagnosed within three years after baseline visits; and a model evaluation and verification module, which is used for performing prediction efficiency evaluation and internal verification on the trained model, so as to obtain a risk prediction model for newly diagnosed lung cancer of benign pulmonary nodule patients within three years. The present application can be used for predicting the risk of progression from benign pulmonary nodule to lung cancer in a large-sample Chinese population.
Owner:SHENZHEN HUARUI TONGKANG BIOTECHNOLOGICAL

Pulmonary nodule automatic labeling method based on multi-modal semantic affinity iterative optimization

The embodiment of the invention provides a pulmonary nodule automatic labeling method based on multi-modal semantic affinity iterative optimization, and belongs to the technical field of data processing, and the method specifically comprises the steps: obtaining a lung CT image and a text report; performing structured semantic analysis on the text report; performing visual feature extraction on the lung CT image; based on the key semantic information, performing semantic guidance processing on the depth visual feature representation to generate semantic enhanced visual guidance features; based on the semantic enhanced visual guidance features, calling a segmentation basic model, and generating a plurality of candidate segmentation masks by introducing an active variation mechanism; for each candidate segmentation mask, calculating a semantic matching degree score of the candidate segmentation mask; and comparing the semantic matching degree scores of all the candidate segmentation masks, and selecting the candidate segmentation mask with the highest score as a final pulmonary nodule labeling result to be output. Through the scheme of the invention, the labeling precision, adaptability and interpretability are improved.
Owner:湖南工商大学

A dandelion flavonoid derivative and its preparation method and application

The present invention discloses a dandelion flavonoid derivative, its preparation method, and application. The dandelion flavonoid derivative has the following molecular structure: The dandelion flavonoid derivative provided by the present invention has anti-inflammatory and lung nodule-removing effects, is simple to prepare, and has good biocompatibility, making it a promising new drug for eliminating lung nodules.
Owner:WUYISHAN CHENGLONG TIANCHUANG TEA CO LTD

Intraoperative pulmonary nodule positioning method and system based on fusion of CT image and endoscope video

The invention discloses an intraoperative pulmonary nodule positioning method and system based on fusion of a CT image and an endoscope video. The method comprises the following steps: firstly, constructing a three-dimensional lung model containing a pulmonary nodule position based on preoperative high-resolution CT data; generating a real-time lung surface model by using an endoscope video stream through a three-dimensional reconstruction technology during the operation; a feature point extraction and matching algorithm is adopted, and a non-rigid registration technology is combined to realize accurate registration of the preoperative model and the intraoperative dynamic model; projection display of pulmonary nodules in a real-time endoscope visual field is established through space coordinate mapping, and a dynamic compensation algorithm is developed to solve the problem of tissue deformation caused by respiratory movement and instrument operation. Meanwhile, the virtual nodule position is overlaid to an endoscope video picture through the augmented reality technology, and visual intraoperative navigation is provided for surgeons. The method effectively solves the technical bottleneck that a traditional method depends on a metal marker and cannot adapt to intraoperative tissue deformation and the like, and has clinical practical value.
Owner:THE SECOND AFFILIATED HOSPITAL OF NANJING UNIV OF TRADITIONAL CHINESE MEDICINE (JIANGSU SECOND HOSPITAL OF TRADITIONAL CHINESE MEDICINE JIANGSU TRAINING CENT FOR TRADITIONAL CHINESE MEDICINE MANAGEMENT CADRES)

Context feature aggregation pulmonary nodule segmentation method combining edge perception and multi-scale semantic guidance

The invention provides a context feature aggregation pulmonary nodule segmentation method combining edge perception and multi-scale semantic guidance, and the method comprises the steps: obtaining a to-be-segmented pulmonary nodule CT image, inputting the to-be-segmented pulmonary nodule CT image into a trained EGP-Net network model, and obtaining a segmentation result; wherein in the EGP-Net network model, multilayer features of an encoder are sent to a global pyramid guide module to reconstruct and selectively introduce deep global semantics back to a shallow layer, and low-layer features are merged into an edge guide network to extract and reinforce fine-grained boundary information; the attention feature fusion module performs weighted attention fusion on global semantics and local edge features, and the multi-scale context decoder fuses multi-scale information through lightweight reconstruction such as sub-pixel convolution to generate a fine segmentation map. Experimental results show that the EGP-Net network model is superior to an existing advanced method in segmentation precision and boundary consistency, and has good clinical auxiliary diagnosis and precision medical application potential.
Owner:LIUZHOU WORKERS HOSPITAL

Pulmonary nodule distinguishing processing method and system based on CT image

The invention relates to a pulmonary nodule distinguishing processing method based on a CT image, and the method comprises the following steps: carrying out the CT scanning of a user, obtaining lung image data, carrying out the three-dimensional reconstruction of the lung image data, and obtaining a three-dimensional image; performing pulmonary nodule attention recognition based on the three-dimensional image through a preset recognition algorithm to obtain a pulmonary nodule image; segmenting the pulmonary nodule image to obtain an internal structure and pulmonary nodule characteristics of the pulmonary nodule; performing risk assessment on the pulmonary nodule based on the internal structure and the pulmonary nodule characteristics to obtain a risk assessment level; if the risk assessment level exceeds a predetermined risk level, classifying the pulmonary nodules corresponding to the risk level exceeding the predetermined risk level to obtain a classification result of the pulmonary nodules; the technical problem that artificial recognition is difficult due to the fact that pulmonary nodules are diverse in form and low in contrast ratio is solved.
Owner:RUIJIN HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE

Pulmonary nodule segmentation method and device based on ABVM-UNet

The invention provides a pulmonary nodule segmentation method and device based on ABVM-UNet, and the method comprises the steps: S1, collecting a lung CT image data set, carrying out the enhancement processing of a pulmonary nodule region in an image, and highlighting the texture and edge features of a nodule; s2, constructing a main branch and a target enhancement auxiliary branch based on a Gabor convolutional neural network to realize enhancement response to pulmonary nodule texture and edge features; s3, using a branch information interaction fusion module BIIF to realize fusion and transmission of auxiliary branch enhancement features; s4, constructing a U-shaped architecture network ABVM-UNet based on Vision Mama, and realizing effective fusion of the local features of the image and the global context information; s5, multi-stage segmentation loss is realized by using depth supervision, and the ABVM-UNet model is trained and optimized; and S6, carrying out pulmonary nodule segmentation on the lung CT image by using an ABVM-UNet model. According to the method, the edge and texture features of the pulmonary nodule are effectively extracted by introducing the ABVM-UNet model, so that accurate segmentation of the pulmonary nodule is realized.
Owner:NANJING CEDONG TECHNOLOGY CO LTD

Pulmonary nodule benign and malignant classification method based on cross-modal space-time fusion network

The invention discloses a pulmonary nodule benign and malignant classification method based on a cross-modal space-time fusion network, and the method comprises the steps: firstly obtaining CT image data, and carrying out the preprocessing of the data, and obtaining an ROI image; then, extracting spatial features in the ROI image through a spatial feature extraction module, and obtaining text features; obtaining fused CT image spatial-temporal features and clinical text features through a time residual fusion module; inputting the output passing through the time residual fusion module into a cross-modal attention fusion network, and performing preliminary fusion to obtain a final cross-modal attention graph; a multi-head self-attention fusion block is used to carry out further fusion processing on the cross-modal attention map, and feature representation based on final fusion spatio-temporal data and clinical data is obtained; and finally, outputting a benign and malignant classification result through an FC layer. Firstly, features are extracted from CT image data of follow-up visit, space-time fusion is carried out, then the features are combined with text clinical data, and the classification accuracy and robustness are effectively improved.
Owner:HANGZHOU DIANZI UNIV +1

Pulmonary nodule malignant classification method based on double-view scanning and hypergraph fusion driving

The invention discloses a pulmonary nodule malignant classification method based on double-view scanning and hypergraph fusion driving, and the method comprises the steps: firstly collecting and preprocessing a pulmonary nodule CT data set which comprises a public data set and a private data set; the method comprises the following steps: building a DPSHG-VMama model for pulmonary nodule classification, wherein the DPSHG-VMama model comprises a stacked convolution Stem block, a text embedding layer, a collaborative fusion Mama block, a stacked DP-VMama block, a patch merging layer for down-sampling and a feature classifier; the preprocessed image data set serves as input, a DPSHG-VMama model is trained, and network parameters are optimized through iteration; and inputting a to-be-classified region-of-interest image into the trained DPSHG-VMama model, and outputting an accurate pulmonary nodule vicious classification result. According to the method, the pulmonary nodule malignancy degree is predicted by effectively establishing the space-time dynamic model and improving the multi-modal fusion efficiency, so that the classification accuracy is remarkably improved.
Owner:HANGZHOU DIANZI UNIV

Mouse model for treating in-situ pulmonary nodules by using bacterial lysate as well as construction method and application of mouse model

The invention discloses a mouse model for treating in-situ pulmonary nodules by using bacterial lysates as well as a construction method and application of the mouse model. The method comprises the following steps: constructing an in-situ pulmonary nodule KT mouse model, instilling adenovirus, randomly dividing the model into an in-situ pulmonary nodule control group and a treatment group, performing bacterial lysate administration on mice in the treatment group at the maximum treatment dosage of 35mg / kg / d, and administering the same dosage of PBS solution to the control group. According to the invention, the possibility of killing cancer cells and preventing precancerous lesion progression by promoting autoimmunity of mice through oral immunostimulation drugs is provided for the first time, namely, the curative effect and mechanism of new drugs are researched through a mouse model, so that the clinical indications of the drugs are widened, and the blank field of clinical pulmonary nodule drug treatment is supplemented.
Owner:ZHONGSHAN HOSPITAL FUDAN UNIV

Pulmonary nodule treatment effect AI evaluation system

The invention relates to the field of medical image processing and artificial intelligence, in particular to a pulmonary nodule treatment effect AI evaluation system which comprises an image acquisition module, an image registration module, a feature representation module, a multi-scale analysis module, a trajectory analysis module, a response prediction module and a decision support module. According to the system, accurate alignment of CT images before and after treatment is realized through a 4D registration technology, manifold representation of a pulmonary nodule state is constructed based on a differential geometry theory, and nodule features are mapped into points on a high-dimensional manifold; extracting features of different time and space scales by adopting multi-scale space-time analysis, and constructing a manifold trajectory representing a treatment response process; geodesic prediction is realized by using a Riemann geometric framework, and long-term curative effect is predicted from early treatment response; the system not only evaluates the current treatment effect, but also can provide personalized treatment suggestions and optimal follow-up visit plans.
Owner:THE AFFILIATED HOSPITAL OF XUZHOU MEDICAL UNIV

Pulmonary nodule detection method based on multi-kernel representation learning

The invention discloses a pulmonary nodule detection method based on multi-kernel representation learning, and belongs to the field of medical image analysis. The method comprises the following steps: S1, obtaining suspected region image block data of which the form is similar to that of a nodule, and carrying out standardization processing; s2, performing feature extraction through principal component analysis according to the normalized image blocks; s3, according to the extracted feature representation, calculating corresponding kernel matrixes by using multiple kernel functions; s4, according to the obtained multiple kernel matrixes, based on spectral entropy weighted fusion, obtaining a mixed kernel matrix; s5, training a single-class support vector machine model according to the mixed kernel matrix, and establishing a discrimination boundary of a normal sample; and S6, in a test stage, repeatedly executing the steps S1 to S4 on suspected nodule region image blocks acquired from the CT image of the patient, extracting features, constructing a mixed kernel matrix, inputting the trained single-class support vector machine model for judgment, and if the suspected nodule region image blocks are abnormal, outputting a nodule region until judgment of all candidate regions is completed. The problems that an existing single-core support vector machine model is poor in adaptability and sensitive to data are solved, the deep learning method depends on a large number of labeled samples, and robust pulmonary nodule detection is achieved under the condition that pulmonary nodule samples are scarce by means of the unsupervised characteristic of anomaly detection.
Owner:SICHUAN UNIV

Pulmonary nodule malignancy probability prediction method based on radiomics and clinical features

The invention discloses a pulmonary nodule malignancy probability prediction method based on radiomics and clinical features, and the method comprises the following steps: collecting and processing original lung image data, and extracting pulmonary nodule image blocks; collecting and processing clinical data of a target patient, and constructing a structured clinical feature vector; inputting the pulmonary nodule image block and the structured feature vector into a dual-channel adaptive fusion network, and extracting an image feature vector and a structured embedded feature vector; a modal sensing module judges that a modal is missing, a modal compensation module is started when the modal is missing, a pseudo-dual-channel output feature pair is generated, and otherwise, a cross attention fusion feature vector is generated; a dynamic fusion module carries out dynamic fusion on the cross attention fusion feature vector or the pseudo dual-channel feature pair, and outputs a dynamic fusion feature vector; and inputting the dynamic fusion feature vector into a classifier, and outputting a malignant probability value of the pulmonary nodule. According to the invention, a dual-channel adaptive fusion network is adopted to realize the intelligent prediction of the malignant probability of pulmonary nodules.
Owner:QICHENG (BEIJING) TECHNOLOGY CO LTD

Lung abnormal nodule recognition processing method and system

The invention discloses a lung abnormal nodule identification processing method and system, and the method comprises the steps: obtaining lung CT image data, and carrying out the preprocessing of the lung CT image data, and obtaining a to-be-detected lung image; performing pixel point analysis on the lung image to be detected by using a discrete fractional differential operator to obtain a fractional order enhanced image; carrying out multi-scale and multi-direction acquisition on pixel points of the fractional order enhanced image to calculate local energy and local entropy, and constructing a high-dimensional fusion feature matrix; carrying out dimensionality reduction on the high-dimensional fusion feature matrix, and extracting to obtain a pulmonary nodule region; the nodule region in the lung CT image can be effectively extracted; through pixel point analysis, calculation of local energy and entropy, and construction and dimension reduction of a high-dimensional feature matrix, the lung abnormal nodule region is finally identified, and the detection precision and efficiency of the pulmonary nodule are improved.
Owner:JIANGXI YITOU MEDICAL IMAGING CO LTD

Pulmonary nodule puncture positioning needle

The utility model relates to the technical field of medical instruments, and discloses a pulmonary nodule puncture positioning needle. The pulmonary nodule puncture positioning needle comprises an outer tube, an inner tube and a positioning marking assembly, the outer tube is provided with a through channel and comprises a needle tube and a needle tube seat, and the needle tube seat is arranged at the near end of the needle tube; the positioning marking assembly is arranged in the outer tube in a sliding mode, a positioning marker of the positioning marking assembly is made of shape memory materials, the inner tube is arranged in a channel of the outer tube in a penetrating mode and used for pushing the positioning marker, and the positioning marker is in a J-shaped hook shape when stretching out of the needle tube. During operation, the outer tube is inserted into a target position of a focus of a patient, the inner tube is pushed, the inner tube pushes the positioning marker out of a needle point of the puncture needle tube, and after the positioning marker is pushed out of the needle tube, the J-shaped hook is self-expanded and recovered to be a preset J-shaped hook. Resistance is formed between the J-shaped hook and pulmonary parenchyma of a patient, the J-shaped hook is positioned at the pulmonary nodule of the patient, and the J-shaped hook structure is beneficial for a doctor to touch and position in an operation and accurately determine the position of a focus.
Owner:HANGZHOU BRONCUS MEDICAL CO LTD

Simple pulmonary nodule positioning device for assisting endoscopic surgery

The utility model provides a simple pulmonary nodule positioning device for assisting endoscopic surgery, which comprises a positioning mechanism marked with scales, and a bipolar electrocoagulation device which can be matched with the positioning mechanism and is used for accurately positioning pulmonary nodules in the auxiliary endoscopic surgery is fixed on the positioning mechanism. And the bipolar electrocoagulation device is connected with a high-frequency generator with a control button. The simple pulmonary nodule positioning device used for assisting the endoscopic surgery is simple in structure and convenient to operate, can accurately position ground glass nodules in the lung by combining an expansion-collapse method, can improve the positioning accuracy of the pulmonary nodules in the surgery, achieves the purpose of accurately excising the pulmonary nodules, reduces excision of lung tissues while ensuring that the incisal margins are negative, and improves the operation efficiency. More lung functions are reserved, so that the operation effect is improved.
Owner:PEKING UNIVERSITY SHENZHEN HOSPITAL