A method comprising receiving a plurality of images from a multi-
modal imaging
system; generating a plurality of filtered measurements by performing multi-
modal spectral fusion of the plurality of images; and generating, using a
physics-informed neural network (PINN) trained based on one or more physical principles associated with X-
ray attenuation or scattering, a reconstructed object
image based on the plurality of filtered measurements, wherein generating the reconstructed object image comprises (i) generating, using the PINN, a
system matrix for an X-
ray imaging forward model by refining one or more coefficients of the
system matrix based on a
physics-informed
loss function, and (ii) generating, using the X-
ray imaging forward model and based on the plurality of filtered measurements, the reconstructed object image.