The invention relates to a method for reconstructing a 3D medical image of a
region of interest from a set of 2D X-
ray images acquired by an X-
ray imaging
system comprising an X-
ray source(S) and an
image detector (D), comprising the steps of: —computing n paths of the X-ray imaging
system, n being an integer greater than or equal to 2, said paths being adapted to acquire n respective subsets of 2D X-ray images together forming the set of 2D X-ray images, each image (IA, IB, IC) of a subset defining a respective cone of projection (CA, CB, CC) of the
region of interest onto the
image detector, such that, for a same position of the X-ray source(S) along the n paths, the cone of projection of an image of any subset is contiguous to the cone of projection of an image of at least one other subset, wherein computing said n paths comprises: —placing a virtual
isocenter (O) of the X-ray imaging
system at a given position or set of positions relative to a center (C) of the
region of interest, and —defining, for each position of the X-ray source along the n paths, the n cones of projection such that the center of a height of an enlarged cone formed by the union of the n cones of projection is said virtual
isocenter (O): —implementing the computed n paths to acquire the n subsets of images: —reconstructing the 3D medical image by intersecting the cones of projection defined by each image of the n subsets.