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71results about How to "High analysis" patented technology

Haplotype analysis

The present invention provides an efficient way for high throughput haplotype analysis. Several polymorphic nucleic acid markers, such as SNPs, can be simultaneously and reliably determined through multiplex PCR of single nucleic acid molecules in several parallel single molecule dilutions and the consequent statistical analysis of the results from these parallel single molecule multiplex PCR reactions results in reliable determination of haplotypes present in the subject. The nucleic acid markers can be of any distance to each other on the chromosome. In addition, an approach wherein overlapping DNA markers are analyzed can be used to link smaller haplotypes into larger haplotypes. Consequently, the invention provides a powerful new tool for diagnostic haplotyping and identifying novel haplotypes.
Owner:TRUSTEES OF BOSTON UNIV

System For The Three-Dimensional Imaging Of A Moving Joint

The invention relates to a system and a method for the generation of 3D images of a moving joint (1). A rotational X-ray device (10) generates projections of said joint from different directions while the simultaneous periodic movement of the joint (1) is recorded by a monitoring device (20). The generated X-ray projections are then classified according to the phase of joint movement to which they belong, and 3D images are reconstructed from X-ray projections of each class. Thus a 3D movie of the joint movement can be produced and shown on a monitor. The monitoring device (20) may particularly be realized by an apparatus that allows the forced movement of the joint (1) in synchronization with the generation of X-ray projections.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV

Haplotype analysis

The present invention provides an efficient way for high throughput haplotype analysis. Several polymorphic nucleic add markers, such as SNPs, can be simultaneously and reliably determined through multiplex PCR of single nucleic acid molecules in several parallel single molecule dilutions and the consequent statistical analysis of the results from these parallel single molecule multiplex PCR reactions results in reliable determination of haplotypes present in the subject. The nucleic acid markers can be of any distance to each other on the chromosome. In addition, an approach wherein overlapping DNA markers are analyzed can be used to link smaller haplotypes into larger haplotypes. Consequently, the invention provides a powerful new tool for diagnostic haplotyping and identifying novel haplotypes.
Owner:TRUSTEES OF BOSTON UNIV

Robotic microscopy systems

The invention comprises a robotic microscope system and methods that allow high through-put analysis biological materials, particularly living cells, and allows precise return to and re-imaging of the same field (e.g., the same cell) that has been imaged earlier. This capability enables experiments and testing hypotheses that deal with causality over time intervals which are not possible with conventional microscopy methods.
Owner:THE J DAVID GLADSTONE INST A TESTAMENTARY TRUST ESTABLISHED UNDER THE WILL OF J DAVID GLADS

Processors for multi-dimensional sequence comparisons

Improved processors and processing methods are disclosed for high-speed computerized comparison analysis of multiple linear symbol or character sequences, such as biological nucleic acid sequences, protein sequences, or other long linear arrays of characters. These improved processors and processing methods, which are suitable for use with recursive analytical techniques such as the Smith-Waterman algorithm, and the like, are optimized for minimum gate count and maximum clock cycle computing efficiency. This is done by interleaving multiple linear sequence comparison operations per processor, which optimizes use of the processor's resources. In use, a plurality of such processors are embedded in high-density integrated circuit chips, and run synchronously to efficiently analyze long sequences. Such processor designs and methods exceed the performance of currently available designs, and facilitate lossless higher dimensional sequence comparison analysis between three or more linear sequences.
Owner:COOKE LAURENCE H +1

Temperature programmed low thermal mass fast liquid chromatography analysis system

InactiveUS20090173146A1Fast heat exchangeHigh throughput analysis rateComponent separationElectronic temperatureCapillary Tubing
A temperature programmed low thermal mass fast liquid chromatography system capable of high throughput and low power consumption includes a straight or curved short reloadable low-mass tubular heater with a capillary column extending inside. If the capillary column is long enough, it is coiled to form a coiled capillary LC column (the length of which does not exceed 0.2 m-1.0 m) packed in a singular module package with a heating wire and a temperature sensing wire extending along and in proximity to the LC capillary column. A tubular heater, e.g. a steel tubing, incorporates the LC capillary column, along with the heating wire and the temperatures sensor and is coiled to form a miniature power saving LC module which may be attached outside a chromatography oven. Capillary lengths extend inside the oven between the inlet and outlet of the LC column module and mobile phase source and detector, respectively. An electronic temperature control block is positioned outside the oven cavity and controls the heating of the capillary LC column, as well as other heated zones in the system.
Owner:AGILENT TECH INC

Composition and method of treating mastitis

A composition and method for treating bacterial infections by the use of an effective amount of at least one lytic specific for the bacteria causing specific. The lytic enzyme is genetically coded for by a bacteriophage which may be specific for said bacteria. The enzyme may be at least one lytic protein or peptides in a natural or modified form.
Owner:LOOMIS LAWRENCE +1

Ppm quantification of iodate using paper device

InactiveUS20150160245A1Superior chemical parameterEasy to analyzeImage enhancementImage analysisIodateSoftware
A highly sensitive method that utilizes a Paper Analytical Device (PAD) which measures part per million (ppm) levels of iodate iodometric titration is provided. The PAD quantifies concentrations of 0.6-15 parts per million (ppm) of iodine. The PAD has at least 12 reaction zones that contain dried reagents thereon and at least one electronically readable information zone. Salt and water are mixed and drops are placed onto 12 reaction zones that contain the loaded dry reagents. The PAD is shaken and the reaction zones turn blue if a preset iodate concentration has been exceeded. Test results are analyzed by comparing the PAD or an image of the PAD with standards, either by eye or with image analysis software to measure the color intensities which are compared to a calibration curve to quantify the iodate levels. The image analysis quantifies iodine with an average absolute accuracy and precision of 0.9 ppm over a range of 0.6-15 ppm.
Owner:UNIV OF NOTRE DAME DU LAC

Cryptographic processing apparatus, cryptographic processing method, and computer program

There is provided a highly secure cryptographic processing apparatus and method where an analysis difficulty is increased. In a Feistel type common key block encrypting process in which an SPN type F function having a nonlinear conversion section and a linear conversion section is repeatedly executed a plurality of rounds. The linear conversion process of an F function corresponding to each of the plurality of rounds is performed as a linear conversion process which employs an MDS (Maximum Distance Separable) matrix, and a linear conversion process is carried out which employs a different MDS matrix at least at each of consecutive odd number rounds and consecutive even number rounds. This structure makes it possible to increase the minimum number (a robustness index against a differential attack in common key block encryption) of the active S box in the entire encrypting function.
Owner:SONY CORP

Vivo isotopic labeling method for quantitative glycomics

The present invention relates to a method of isotopically labeling glycans and in facilitating high throughput quantitative / comparative analysis of glycomic compositions of biological cells. The method is applicable inter alia for identifying differentiated cells and their glycomic characteristics, differentiation conditions, disease and / or therapeutic progression, diagnosing disease states, determining drug activity, establishing manufacturing efficiencies and for determining the half-life of glycans in cells.
Owner:UNIV OF GEORGIA RES FOUND INC

Automatic analyzer and analysis method for use in the same

An automatic analyzer having a high processing capability even when plural kinds of reagents are dispensed at different timings. The automatic analyzer comprises a plurality of reaction cells, a reaction cell moving unit for moving the plurality of reaction cells at a certain cycle; a sample dispensing unit for dispensing a sample into a reaction cell on the reaction cell moving unit, a reagent dispensing unit for dispensing plural kinds of reagents to be added during a sample—reagent reaction process at different timings, the number of the reagent addition timings being larger than the number of times at which the reagents can be dispensed within a time of one cycle, and a control unit for controlling the sample dispensing unit to set a cycle in which no sample is dispensed by the sample dispensing unit, when analyses each using the reagent to be dispensed at the latest one of the reagent addition timings by the reagent dispensing unit succeed a predetermined number of times or more.
Owner:YAMAZAKI ISAO +1

Neuromorphic Digital Focal Plane Array

This invention discloses a multispectral imaging system, DFPA (digital focal plane array), in the form of an integrated circuit of three structures each of which is implemented on a chip. The top structure consists of detectors capable of imaging in the visible to LWIR wavelengths. The middle structure of neuromorphic focal array contains ROI circuitry and inherent computing capabilities for digitization, convolution, background suppression, thresholding, and centroid determination of the ROIs. The bottom structure (dubbed common digital layer) is capable of additional image processing tasks and reconfiguring the neuromorphic focal array. In a simpler embodiment of the invention, the system only has the top two layers, with an external processor taking over the role of the common digital layer.
Owner:CHARLES STARK DRAPER LABORATORY

Multi-level diagnostic apparatus with a lift system

A new apparatus is disclosed which is useful for high throughput of samples without necessity of interrupting any analysis performed on said apparatus for reloading of disposables.
Owner:ROCHE MOLECULAR SYST INC

Homogenous enzyme immunoassay process

An improved homogeneous enzyme immunoassay process for quantitatively analyzing an antigen by determining the change in the enzymatic activity caused by a reaction between the antigen and an enzyme-labeled antibody. The antigen is reacted with an enzyme-labeled antibody, followed by the reaction with a second antibody capable of recognizing and binding to a different epitope and then with a third antibody capable of recognizing and binding to the second antibody. The enzymatic activity of the labeling enzyme is determined by a water-insoluble substrate. Using the water-insoluble substrate, steric hindrance is enhanced. A highly-sensitive analysis can be carried out by a simple operation even when the antigen has a molecular weight falling within an intermediate range, for example, a range of M.W. 10,000 to 70,000.
Owner:FUJIFILM HLDG CORP

Low pressure anion exchange chromatography-turbidimetric method for simultaneous online analysis of trace sulfide and chloride in water samples

The present invention provides a low pressure anion exchange chromatography—turbidimetric method for simultaneous online analysis of trace S2− and Cl− in water samples using an apparatus comprising a low pressure pump, a sample valve, a sample loop, a low pressure anion chromatographic column, a reactor, an optical flow cell, an optical detector, a computer system, a mixer, a sample flow path, a propelling solution flow path, and a color developer solution flow path, the method comprising: (a) mapping a baseline; (b) mapping spectrogram of S2− and Cl− in test samples; (c) mapping standard working curves; and (d) calculating the concentrations of S2− and Cl− in the test samples based on the peak heights of S2− and Cl− in the spectrogram and the regression equations of standard working curves. In this method, a chromatography method is combined with a turbidimetric method for the first time to realize simultaneous online analysis of trace S2− and Cl− in water samples, and the method is endowed with the advantages of fast analysis speed, high analysis efficiency and low analysis costs.
Owner:SICHUAN UNIV

Mass analysis system

An object of the present invention is to evaluate quantitatively a peptide derived from a protein, whose analysis has been difficult so far, by analyzing a peptide ion derived from a protein already measured but having a different total ion amount as the tandem mass analysis target at the time of quantitatively evaluating a fluctuating component between different kinds of specimens by the tandem mass analysis of a protein or a peptide. In the present invention, in order to achieve the above-mentioned object, data of a derived peptide obtained by a first time measurement are stored automatically in an internal database and collated with second time measurement data highly accurately. The processing for selecting the peak of the already measured peptide with the relative amount fluctuation as the next tandem analysis target is implemented within the real time of the measurement for avoiding the analysis of a peptide without the relative amount fluctuation.
Owner:HITACHI LTD

Automated Tennis Stroke Counter and Analyzer

An electronic device that automatically counts and measures power of the impacts of a tennis ball with a tennis racket during play. The housing of said device comprises a mounting apparatus which is mechanically configured so that a player using said device will be able to easily mount said device on a tennis racket or on the player's arm. Said device is electronically configured so that a player using said device is able to keep a count of the type of tennis strokes that are struck by the player during the course of play. Said device is further configured so that it is able to count the total number of strokes hit by a tennis player. Said device is further electronically configured so that a player using said device is able to determine the amount of force that a tennis ball makes against a tennis racket with each contact with a tennis ball. Said device is further configured with a display that will allow for a player using said device to read information provided by said device.
Owner:JACKSON KEVIN DEON

Systems and Methods for Analyzing and Assessing Attention Deficit Hyperactivity Disorder

Embodiments of the invention can provide systems and methods for analyzing and assessing attention deficit hyperactivity disorder (ADHD) by integrating the use of electroencephalography (EEG), and ADHD diagnostic and assessment tools, such as an ADHD rating scale. Embodiments of the invention can provide some or all of the following improvements over conventional systems and methods, including: (1) Increased sensitivity, specificity, and overall accuracy; (2) Improved detection of ADHD; and (3) Distinguishing subjects with ADHD from subjects with a different disorder but having ADHD-like symptoms, such as attention and behavior symptoms similar to ADHD.
Owner:LEXICOR MEDICAL TECH

Method for processing data structures

A method for processing data structures with the aid of networked semantic units includes: acquiring a data structure, and generating, modifying, deleting and storing semantic structure units and networking them on the basis of the acquired data structure while using a knowledge base comprised of a network of semantic knowledge units. Semantic structure units and their network are classified in iterative steps. Based on this classification, a specific processing is activated which modifies a respective semantic structure unit and a particular partial network.
Owner:DEFINIENS AG

Nickel Crucible for Melting Analytical Sample, Method of Preparing Analytical Sample and Method of Analysis

ActiveUS20100167407A1High precision analysisFast and accurate measurement of high purity materialsAnalysis using chemical indicatorsWithdrawing sample devicesLower limitCrucible
A nickel crucible used for melting an analytical sample in the pretreatment of the analytical sample, characterized in that the purity of the nickel crucible is 99.9999 wt % or higher. Also provided is a method of analysis, comprising melting a sample by the use of the nickel crucible for melting having a purity of 99.9999 wt % or higher, and analyzing the melt to thereby obtain an analytical result in which the respective lower limits of determination of Mn, Al, Si, Mg, Pb, Fe, Co, Ti, Cu, Cr, Zr, Mo, and W are Mn: 5 wtppm, Al: 10 wtppm, Si: 10 wtppm, Mg: 5 wtppm, Pb: 5 wtppm, Fe: 5 wtppm, Co: 5 wtppm, Ti: 20 wtppm, Cu: 20 wtppm, Cr: 10 wtppm, Zr: 5 wtppm, Mo: 2 wtppm, and W:10 wtppm. In light of the recent analytical technology demanded of fast and accurate measurement of high purity materials, high purity analysis is attained through inhibition of mixing of impurities from the crucible.
Owner:JX NIPPON MINING& METALS CORP

Diagnostic methods for protein profiling

Methods for establishing a protein expression profile of a biological sample, by contacting a biological sample with a ubiquitin-binding protein such that ubiquitinated and specific non-ubiquitinated protein (the IPS) bind to the ubiquitin-binding protein; isolating the IPS proteins; and analyzing the isolated IPS proteins, wherein an expression profile is generated.
Owner:RUTGERS THE STATE UNIV

Narrow bore layer open tube capillary column and uses thereof

A polymer-based PLOT column prepared by in situ copolymerization of a functional monomer, which usually contains the retentive chemistries, and a crosslinking monomer, which enhances the strength of the polymer matrix, is disclosed. Styrenic based monomers such as styrene and divinylbenzene or meth / acrylic based monomers such as butyl or stearyl methacrylate and ethylene glycol dimethacrylate, are preferred. Columns of the invention can be prepared in a robust fashion with a very narrow i.d., e.g., 5-15 μm. Thus, they are suitable for commercial use in ultratrace LC / MS proteomic analysis. Columns according to the invention are characterized by high resolving power, high column-to-column reproducibility and relatively high loading capacity. When these columns are coupled on-line with, e.g., ESI-MS detection, the resulting systems provide high sensitivity for analysis of complex proteomic samples, even down to the low attomole to sub-attomole level.
Owner:NORTHEASTERN UNIV
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