154results about How to "High precision analysis" patented technology

Provided are highly precise automatic analysis devices capable of both measurement over a wide concentration range and increased sensitivity at low concentrations. Signals of multiple wavelengths Lambda1-Lambda12 from a light source (40) and that are highly susceptible to light absorption by microparticles are converted to absorbances in a spectrophotometric system (detector 41). The absorbances are converted using a previously defined conversion table (54) to secondary parameters wherein the noise component has been cancelled. Based on said secondary parameters, the concentration of the measured substance (prescribed component) is calculated by a calculating unit (computing means 53). Analysis up to high concentrations and that is resistant to noise even at low concentrations is thereby made possible.

In a chemical analysis apparatus for extracting a specific substance, such as nucleic acid, from a sample containing a plurality of chemical substances, solutions remaining in valves are prevented so that a reagent in an earlier step does not contaminate the subsequent steps. Predetermined quantities of solutions are carried and supplied by centrifugal force without providing valves for controlling the flow of the solutions. After perforating the lids of ventilation holes 272, 273, 274 communicated with a detection container 450 and disposal containers 460 and 470 in an analysis disc 2, the analysis disc 2 is rotated to supply and carry a predetermined quantity of the sample.

A method for analyzing a multi-channel chromatogram is realized for accurately resolving overlapping peaks on a multi-channel chromatogram to permit analysis of the composition of a sample. First, components of overlapping peaks are specified. A data matrix Dij is determined, and compressed in the wavelength direction to obtain a data matrix vector Di. Next, the two-dimensional data is deconvoluted, final standard deviation s0 is registered, and the deconvoluted two-dimensional data is reconvoluted to a retention intensity matrix. A quantitative spectral intensity matrix is computed, components are identified, and the identified components are quantified. Subsequently, an eigenvalue problem is solved, and the number n of components is estimated. The deconvolution and computation of the eigenvalue problem are iteratively executed until the peaks are isolated. Then, elution profiles are calculated, the components are identified, and the identified components are quantified.

A microchip includes a clad layer having a channel through which a sample flows, and an optical waveguide formed within the clad layer and having a higher refractive index than the clad layer. The optical waveguide is formed to act on the channel optically. Thus, the sample flowing in the channel can be analyzed with high accuracy even in the microchip having a fine structure.

A sample analyzing method capable of high-precision analysis without being affected by vibration and optical design is provided. In the sample analyzing method, a sample containing a ligand is caused to bind to a receptor that can bind specifically to the ligand, and a change caused by binding of the receptor and the ligand is analyzed by measuring frequency characteristics of a surface plasmon resonance angle while applying external vibration to the receptor. The sample analyzing method is useful in the fields of, for example, biology, medicine, pharmacology, agriculture, and the like.

A method for analyzing a multichannel chromatogram is realized for accurately resolving overlapping peaks on a multichannel chromatogram to permit analysis of the composition of a sample.

Provided are a microchip including a fluid circuit consisting of a space formed therein, a light-absorbing first substrate and a light-transmitting second substrate bonded onto the first substrate, and a groove, having a V-shaped section, extending parallelly to the fluid circuit on a surface of the second substrate opposite to the first substrate on a position immediately above at least part of the fluid circuit and a method of manufacturing the same.