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1138results about "Phase-affecting property measurements" patented technology

Refractive index structure constant adaptive forecasting method and system based on atmospheric turbulence multi-scale characteristics

The invention discloses a refractive index structure constant adaptive forecasting method and system based on atmospheric turbulence multi-scale characteristics. The method comprises the following steps: 1, measuring and preprocessing an atmospheric refractive index structure constant; 2, constructing a spatial-temporal feature extraction module of an atmospheric turbulence refractive index structure constant; 3, learning a dependency relationship representing a long-time sequence by using a gating mechanism, and constructing a long-time correlation feature extraction module; 4, capturing dependency relationships of different times through convolution kernels of different time steps, and constructing a short-time correlation feature extraction module; 5, designing a self-adaptive turbulence multi-scale feature fusion module which comprises three groups of bidirectional cross attention modules to realize alignment and fusion among different turbulence feature extraction modules; and introducing a gating mechanism, performing dynamic control and feature selection on output information streams of the three groups of bidirectional cross attention modules, and simulating the change of importance of different scale features of turbulence along with conditions to obtain a predicted value.
Owner:HANGZHOU DIANZI UNIV

Visualization method for detecting mango quality based on hyperspectrum

The invention relates to the field of optical nondestructive testing, and discloses a visualization method for detecting mango quality based on hyperspectrum, which comprises the following steps of: firstly, selecting mango samples, and simulating different mango ripening stages by dividing the mango samples into a plurality of groups of samples; acquiring a high-dimensional spectral image by using a hyperspectral imaging system, and measuring the hardness, the soluble solid content and the titratable acid content; correcting and extracting the high-dimensional spectral image to obtain and optimize the average reflection spectrum of the sample, and establishing a mango maturity classification model and a quality regression prediction model; performing characteristic wavelength contribution degree analysis and screening, and optimizing a quality regression prediction model by adopting a key wave band; the method is applied to each pixel point of a high-dimensional spectral image, a two-dimensional distribution diagram is generated, and mango quality visualization is achieved. The method solves the problems that in the prior art, rapid and lossless judgment of the mango ripening stage cannot be achieved, accurate prediction and visual distribution of key internal quality indexes cannot be achieved, and intelligent grading and quality control of picked fruits are not ideal.
Owner:SANYA INSTITUTE OF NANJING AGRICULTURAL UNIVERSITY

Optical fiber hydrogen sensor for detecting hydrogen in water

The invention belongs to the technical field of hydrogen detection sensing, and particularly relates to an optical fiber hydrogen sensor for detecting hydrogen in water. The optical fiber hydrogen sensor consists of a demodulator and a hydrogen-sensitive optical fiber, wherein the hydrogen-sensitive optical fiber consists of an optical fiber, a WO3 / Pt layer and an ePTFE hydrophobic breathable film from inside to outside, wherein the WO3 / Pt layer is coated outside the optical fiber, and the ePTFE hydrophobic breathable film is coated outside the WO3 / Pt layer. The optical fiber hydrogen sensor is small in size, and the defect that a traditional hydrogen sensor is not suitable for a narrow space in a small chamber of a water electrolysis hydrogen production tank is overcome. The problems of spectrum jitter and abnormal interference caused by the fact that a traditional optical fiber hydrogen sensor is affected by water in an electrolytic bath environment are solved through the hydrophobic breathable film. The hydrogen sensor disclosed by the invention provides a real-time and stable quantitative means for solving the problem that hydrogen concentration cannot be effectively measured due to mixing of hydrogen and oxygen in a small chamber, a water outlet and an oxygen outlet of a water electrolysis hydrogen production tank.
Owner:NANJING UNIV OF POSTS & TELECOMM

An on-chip photo-thermal gas sensor and an on-chip photo-thermal gas sensor assembly

The present application relates to a kind of on-chip photo-thermal gas sensor and on-chip photo-thermal gas sensor assembly, the refractive index of the upper waveguide material layer of sensor ridge waveguide layer is greater than the refractive index of lower waveguide material layer, can support TM mode pump light and TE mode probe light simultaneously. That is, both high absorption of pump light and weak influence of probe light on the gas to be measured are considered, and the detection accuracy of the gas is improved. Moreover, a simpler waveguide structure is used, and the waveguide preparation process is simple, and the waveguide loss is relatively low. Compared with the photo-thermal interference method in optical fiber sensing, the interaction between pump light and the gas to be measured is greatly improved, the length of the detection waveguide is greatly shortened while ensuring high sensitivity, and the device size can be reduced to micrometer level. In addition, the waveguide structure of the on-chip photo-thermal gas sensor disclosed in the present application is prepared from chalcogenide glass, which has more obvious advantages for gas detection in the mid-infrared waveband.
Owner:ZHEJIANG LAB

Semiconductor device inspection method

A semiconductor device inspection method includes: selecting, for a semiconductor device including at least one layer, a target layer on which inspection and measurement are to be performed; selecting a material to fill a hole region formed inside the semiconductor device; conducting a simulation for an optical inspection and a measurement for the semiconductor device; selecting, based on the simulation, a wavelength band of light for the optical inspection and the measurement; and detecting, through the light at the selected wavelength, a lower portion of the semiconductor device and a defect of the semiconductor device. A refractive index of the material filling the inside of the hole region is greater than a refractive index of a molding layer surrounding the outside of the hole region.
Owner:SAMSUNG ELECTRONICS CO LTD

Optical fiber twinborn controllable vernier hydrogen sensor and detection method

The invention discloses an optical fiber twinning controllable vernier hydrogen sensor and a detection method, and belongs to the technical field of optical fiber sensing, the optical fiber twinning controllable vernier hydrogen sensor comprises a single-mode optical fiber, a femtosecond laser direct writing grating, a Fabry-Perot interferometer and a Pd / WO3 hydrogen sensitive film; the single-mode optical fiber comprises an optical fiber core and an optical fiber cladding, the femtosecond laser direct writing grating is prepared in the optical fiber core, the Fabry-Perot interferometer is composed of a reflecting surface 1 and a reflecting surface 2 which are relatively parallel to each other, the Pd / WO3 hydrogen sensitive film is coated on the inner side of the reflecting surface 2, and the femtosecond laser direct writing grating and the Fabry-Perot interferometer are arranged in series; the optical path of the Fabry-Perot interferometer is modulated through the interaction of the Pd / WO3 hydrogen sensitive film and hydrogen, interference spectrum wavelength drift is triggered, temperature compensation is achieved in combination with the temperature response of the femtosecond laser direct writing grating, and hydrogen concentration sensing is completed. The method is suitable for hydrogen leakage detection in industrial environments, energy equipment and other scenes.
Owner:NORTHEASTERN UNIV AT QINHUANGDAO

High-sensitivity double Fabry-Perot interference hydrogen sensor resistant to temperature and humidity interference

The invention discloses a high-sensitivity double Fabry-Perot interference hydrogen sensor resistant to temperature and humidity interference, and belongs to the technical field of optical fiber sensing. A modular integrated design is adopted, and the core comprises double Fabry-Perot interferometers which are connected in series and are respectively a temperature compensation unit FPI-1 and a hydrogen sensing unit FPI-2, and a matched software controllable vernier processing module; the FPI-1 realizes temperature real-time compensation by filling PDMS in an open microcavity, and the FPI-2 adopts a PDMS / Pd-WO3 composite material as a hydrogen sensitive layer, and has wide humidity range anti-interference capability through structural optimization; the weak hydrogen signal is amplified through Fourier transform filtering, sine function fitting, twin interference spectrum construction and vernier effect. According to the invention, precise detection of ultra-trace hydrogen in a complex temperature and humidity environment is realized, and the temperature and humidity interference resistance is high.
Owner:NORTHEASTERN UNIV AT QINHUANGDAO

Inversion method for obtaining N2O gas volume mixing ratio profile based on short wave infrared laser occultation detection technology

The invention discloses an inversion method for obtaining an N2O gas volume mixing ratio profile based on a short-wave infrared laser occultation detection technology. The inversion method comprises the following steps: calculating a short-wave infrared atmospheric refractive index profile at the center position of an N2O gas absorption spectral line; calculating a collision parameter profile according to the short-wave infrared atmospheric refractive index profile, respectively calculating atmospheric transmittance profiles of an N2O gas absorption spectral line and a reference spectral line based on normalized energy data of infrared laser occultation detection, and executing Abel integral inverse transformation on a difference value between the atmospheric transmittance profiles to obtain an N2O gas absorption coefficient profile; converting the N2O gas absorption coefficient profile into an N2O gas initial volume mixing ratio profile; and by taking the N2O gas initial volume mixing ratio profile as an initial value, carrying out analog calculation on an atmospheric transmittance profile after N2O gas absorption, constructing a cost function, carrying out iterative optimization, outputting an N2O gas volume mixing ratio profile, and obtaining a final inversion result. According to the method, the inversion precision is improved.
Owner:INST OF ATMOSPHERIC PHYSICS CHINESE ACADEMY SCI

Rheological-birefringence combined in-situ testing device and method based on chopper rotation frequency signal

The invention discloses a rheology-birefringence combined in-situ testing device and method based on chopper rotation frequency signals, belongs to the technical field of optical testing, and aims to solve the technical problems that an existing Spark-FB device is low in measurement accuracy and limits application scenes. The laser emitter emits a light beam along a set angle (forming an angle of 45 degrees with the horizontal plane), the light beam is converted into linearly polarized light through the polarizer, and an optical signal is modulated through the rotating chopper; the modulated light beam penetrates through a polymer sample to which a shear flow field is applied by a commercial rheometer, and transmission light carrying optical anisotropy information of the sample sequentially passes through a 1 / 4 wave plate and a polarization analyzer, and is finally received by a photoelectric detector and transmitted to a lock-in amplifier for analysis. According to the invention, an independent datum reference signal is provided through the chopper, decoupling and combination of a commercial rheometer and a birefringence light path are realized, and synchronous and accurate in-situ measurement of rheological and optical properties of a high polymer material under a deformation condition can be realized.
Owner:CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY CHINESE ACADEMY OF SCIENCES

A laser cavity diagnosis device and method based on double frame delay synchronization phase shift

The application discloses a laser cavity diagnosis device and method based on double-frame delay synchronization phase shift, which comprises an excitation module and a detection module; the excitation module comprises a first laser, a first 1 / 2 wave plate, a polarization beam splitter prism, a beam splitter, an energy meter, a convex lens and a water tank; the detection module comprises a second laser, a beam expander lens group, a second 1 / 2 wave plate, a second polarization beam splitter prism, a third 1 / 2 wave plate, a first reflector, a second reflector, a fourth 1 / 2 wave plate, a third polarization beam splitter prism, a third reflector, a fourth polarization beam splitter prism, a first 1 / 4 wave plate, a first imaging lens, a first micro-polarization camera, a second 1 / 4 wave plate, a second imaging lens and a second micro-polarization camera. The application introduces a double-frame delay method in the traditional synchronous phase shift interference, overcomes the defects of the existing cavity detection technology, and realizes the observation of the instantaneous phase change in a single cavity pulsation period.
Owner:NANJING UNIV OF SCI & TECH

Self-calibration method for refraction parameters of underwater binocular vision system

The invention belongs to the technical field of underwater vision measurement, and relates to an underwater binocular vision system refraction parameter self-calibration method, which comprises the following steps of: firstly, constructing a space equation containing a water body refractive index, a refraction interface normal vector, an interface distance and a light path coefficient based on a Snell law; constructing a generalized state vector including an environment parameter, a structure parameter and a path parameter; a system residual equation is established by using different-plane light intersection constraint of binocular vision, and nonlinear iterative least square solution is carried out by constructing a generalized Jacobian matrix so as to realize adaptive calibration of an underwater vision system; according to the method, on the premise that water body parameters do not need to be predicted and high-precision mechanical calibration is not needed, the water body refractive index and the system structure parameters are synchronously solved, self-adaptive calibration of the underwater vision system is achieved, and the three-dimensional measurement precision and robustness in the complex water environment are remarkably improved.
Owner:CHINA UNIV OF MINING & TECH

Anti-resonance effect-based microfluidic temperature-salt two-parameter optical fiber sensor and preparation method and test system thereof

The invention relates to the technical field of optical fiber sensing, and provides a micro-fluidic temperature and salt control two-parameter optical fiber sensor based on an anti-resonance effect and a preparation method and a test system thereof, the optical fiber sensor comprises a leading-in single-mode optical fiber, a hollow-core tubular optical fiber, a side single-hole double-core optical fiber and a leading-out single-mode optical fiber which are cascaded in sequence; a micro-groove is etched at the cladding of the fusion welding end of the introduction single-mode fiber and the hollow-core tubular fiber; the side wall of the hollow-core tubular optical fiber is etched with a micro-channel which vertically penetrates through the cladding of the hollow-core tubular optical fiber. The side single-hole double-core optical fiber is located between the hollow-core tubular optical fiber and the leading-out single-mode optical fiber, and an air hole parallel to the axial direction is formed in the side single-hole double-core optical fiber to form a fluid outflow channel; through the scheme, the response speed and the detection sensitivity are improved.
Owner:NORTHEASTERN UNIV CHINA

Refractive index sensor based on surface lattice resonance

The invention provides a refractive index sensor based on surface lattice resonance, belongs to the technical field of micro-nano sensors, and aims to solve the problem that the sensitivity and quality factor are low when the environmental refractive index is detected. The structure of the refractive index sensor sequentially comprises a substrate, a metal layer, a dielectric layer and a periodic structure layer from bottom to top, the periodic structure layer is an array formed by periodically arranging metal nanoparticles according to a rule, and the metal nanoparticles are hemispherical metal nanoparticles. The sensor device provided by the invention can realize high refractive index sensitivity and high quality factor, the refractive index sensitivity reaches 562.42 nm / RIU, the quality factor (FOM) is 54.38 RIU-1, and the sensor device is very suitable for biomedical sensing application.
Owner:THE THIRD AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY

Glass outer diameter screening method based on intelligent feedback control

The invention provides an intelligent feedback control glass outer diameter screening method, which comprises the following steps: collecting the reflected light intensity and refracted light angle of the surface of glass, analyzing the spatial frequency distribution characteristics of local scattering intensity, identifying the surface microcrack distribution mode and quantifying the defect depth change; distinguishing real structure defects and surface tiny scratches, and obtaining defect boundary sharpness and defect size distribution parameters; based on the denoised signal data, dynamic evolution characteristics of defect distribution are extracted, and a space-time incidence matrix containing light intensity spatial frequency periodicity and angle deviation periodicity is constructed; carrying out weight redistribution on the space-time incidence matrix by utilizing a dynamic weight distribution coefficient, and carrying out weighted fusion on local scattering intensity information and refracted light phase difference information to generate a fused feature signal; based on the space-time characteristic parameters of the fused characteristic signals, the influence of sudden drop of reflected light intensity and signal distortion on outer diameter judgment is reduced to the maximum extent, and optimized outer diameter judgment signals are output.
Owner:GUANGZHOU HUABAO GLASS IND CO LTD

Laser cleaning device for refractometer

The utility model relates to a laser cleaning device for a refractometer. The laser cleaning device comprises a refractometer prism, an optical fiber and a laser, the refractometer prism is embedded in the end face of the online refractometer and comprises a first plane and a second plane; the first plane is exposed out of the outer surface of the end face of the online refractometer and is in contact with to-be-detected liquid; the second plane is opposite to the first plane and is positioned in the online refractometer; the optical fiber is arranged in the online refractometer and comprises a first end face and a second end face; the first end face is opposite to a second plane of the refractometer prism, and the second end face is connected with the laser; the laser is used for generating a laser beam capable of cleaning dirt attached to the first plane. The cleaning degree of cleaning can be greatly improved, noise and vibration are avoided, no mechanical operation part exists, energy is saved, cleaning can be conducted while measurement is conducted, and the measurement precision is not affected.
Owner:BEIJING LINGHANG LIJIA ELECTROMECHANICAL

Surface plasma resonance hydrogen sensor based on Ag / PDMS / Pt-WO3 multilayer structure

The invention discloses a surface plasmon resonance (SPR) hydrogen sensor based on an Ag / PDMS / Pt-WO3 multilayer structure. The SPR hydrogen sensor is characterized by comprising a halogen lamp light source, two sections of multimode optical fibers, a spectrometer and an SPR hydrogen sensing head, wherein the SPR hydrogen sensing head is composed of a different-core structure formed by multimode-single-mode-multimode optical fibers, a silver film, PDMS (polydimethylsiloxane) and Pt-WO3 (platinum-tungsten trioxide). The SPR hydrogen sensor based on the Ag / PDMS / Pt-WO3 multi-layer structure, which is simple to prepare, high in sensitivity and capable of being repeatedly used for a long time, is provided aiming at the defects that an existing optical fiber SPR hydrogen sensor is low in sensitivity and complex in device manufacturing, and PdH is changed from an alpha phase to a beta phase when Pd is used as a hydrogen sensitive material, so that the use of the device is influenced, and the like. When the hydrogen concentration is increased, the Pt-WO3 reacts with the hydrogen to generate heat, so that the refractive index of the PDMS film is changed, the SPR resonance spectrum is moved, and the hydrogen concentration is obtained by observing the offset of the PDMS film. The high refractive index sensitivity of SPR is brought into full play by utilizing the high refractive index change of PDMS, so that high-precision detection of hydrogen leakage is realized.
Owner:CHINA JILIANG UNIV

Spectral enhancement filtering metasurface method based on multi-physics field coupling

The invention provides a spectrum enhancement filtering metasurface method based on multi-physics field coupling, and the method comprises the steps: building a heat-force multi-physics field model of a metasurface under the incidence of high-power laser, obtaining a temperature field through calculation, and recognizing a hot spot region based on the temperature field; calculating a thermal stress field based on the temperature field, calculating refractive index variation and distribution of the metasurface material based on the temperature field and the thermal stress field, further quantifying resonant wavelength drift caused by the refractive index variation, and positioning an optical mode mismatch area; reversely designing geometric parameters of a compensation structure based on the resonant wavelength drift distance and the optical mode mismatching region; preparing a compensation type metasurface sample according to the geometric parameters, and testing the spectral response of the compensation type metasurface sample under high-power laser; based on the spectral response, the spectral enhancement filtering stability of the compensation type metasurface sample is evaluated, the problem of thermal-optical mismatch caused by high-power laser is solved, and long-term stable operation of the spectral filtering function in a severe environment is achieved.
Owner:NANJING NANZHI INST OF ADVANCED OPTOELECTRONIC INTEGRATION NANJING

Optical device and spectroscopic device

An optical device includes: an incident optical system; an analysis optical system; and a length measurement optical system. The incident optical system includes a laser light source, and an incident light dividing element that divides the laser light. The analysis optical system includes a first light dividing element that divides the first divided light and then mixes the light, a first mirror that adds a first modulation signal to the one first divided light by movement and reflection, a second mirror, and a first light receiving element that receives the first divided light including a sample-derived signal and the first modulation signal. The length measurement optical system includes a second light dividing element that divides the second divided light and then mixes the light, an optical feedback unit that feeds back the one second divided light to the second light dividing element, and a second light receiving element that receives the second divided light including a displacement signal generated by the first mirror.
Owner:SEIKO EPSON CORP

MXene-based dual-channel cascaded coreless optical fiber SPR sensor and application thereof

The invention discloses an MXene-based dual-channel cascade coreless optical fiber SPR sensor and application thereof, the sensor is formed by cascading a multimode optical fiber with two sections of coreless optical fibers, the NCF area of the channel 1 is only coated with a gold film, and the NCF area of the channel 2 is coated with a gold-cysteamine-MXene composite film. Theoretical analysis shows that when the NCF lengths of the channel 1 and the channel 2 are 5 mm and 12 mm respectively, the visibility of formants is optimal, and the distance between the formants can be increased by increasing the thickness of MXene. Experiments show that in the refractive index range of 1.333-1.366, the optimal number of layers of MXene is four, at the moment, the RI sensitivity of a channel 1 and the RI sensitivity of a channel 2 reach 1894.27 nm / RIU and 4001.48 nm / RIU respectively, and the FOM is 16.86 RIU <-1 > and 32.99 RIU <-1 > respectively. The device is simple in structure, low in cost and convenient to operate, and has good application potential in the field of two-parameter biochemical sensing.
Owner:CHONGQING UNIV OF TECH

Wide-field Fourier transform hyperspectral imaging device and system

The utility model discloses a wide-field Fourier transform hyperspectral imaging device and system, and the device comprises a microscope assembly which is disposed at one side of an imaging sample, and is used for carrying out the focusing amplification imaging of the imaging sample, and then outputting corresponding first signal light; the input end of the pulse shaping assembly is arranged corresponding to the output light path of the microscope assembly, and the pulse shaping assembly is used for modulating and shaping the first signal light output by the microscope assembly and then outputting an interference signal of the whole imaging sample; the input end of the imaging detection assembly is arranged corresponding to the output light path of the pulse shaping assembly, and the imaging detection assembly is used for focusing, imaging and detecting the interference signals, output by the pulse shaping assembly, of the imaging sample at different spatial positions, converting the interference signals into a plurality of electric signals and outputting the electric signals. The utility model aims to improve the scanning speed of the imaging sample.
Owner:SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY

Urea concentration sampling detection device and method thereof

The invention relates to the related technical field of power plant wastewater detection, in particular to a urea concentration sampling detection device and a method thereof.The urea concentration sampling detection device comprises a sewage pail and a booster water pump installed at the bottom of the sewage pail, the output end of the booster water pump is connected with a conveying pipe, and an arc-shaped detection pipe is arranged at the top of the conveying pipe; a detector with a detection probe is arranged at the inner top of the arc-shaped detection pipe, a rotation stabilizing assembly is arranged in the arc-shaped detection pipe, impurities and bubbles adhered to the detection probe in the detection process are eliminated through the rotation stabilizing assembly, the rotation stabilizing assembly fundamentally eliminates refractive index measurement errors caused by the bubbles, and the detection accuracy is improved. When the arc-shaped cleaning plate cleans the detection probe, impurities attached to the movable brush are brushed away synchronously, the movable brush is effectively prevented from becoming a secondary pollution source, it is guaranteed that the detection probe and the movable brush are clean for a long time, and the follow-up cleaning capacity for the detection probe is improved.
Owner:THE SECOND SHANXI PUCHENG HUADIAN POWER GENERATION CO LTD

Phase recovery method and device based on improved high-order light intensity transmission equation

The invention discloses a phase recovery method and device based on an improved high-order light intensity transmission equation, and relates to the field of precision optical detection. The defects that an existing multi-defocus-plane high-order light intensity transmission equation needs to collect a large number of defocus images, the efficiency is low, equipment moves frequently, and the controllability of a double-defocus-plane algorithm is low are overcome. Collecting a focusing intensity graph, a first out-of-focus intensity graph and a second out-of-focus intensity graph of the to-be-detected sample, determining a third fuzzy parameter of an interpolation image according to the first fuzzy parameter, the second fuzzy parameter and the interpolation coefficient, and obtaining an interpolation intensity graph of the interpolation image based on Fourier transform on the first out-of-focus intensity graph, the second out-of-focus intensity graph and the interpolation coefficient; weighting the interpolation intensity graph, the first out-of-focus intensity graph and the second out-of-focus intensity graph according to the intensity coefficient to obtain a high-order light intensity axial derivative corresponding to the focusing intensity graph; and solving the high-order light intensity axial derivative to obtain the phase distribution of the to-be-measured sample.
Owner:XIAN TECH UNIV

Split prism silicon-based liquid immersion microchannel measuring device and method

A split prism silicon-based immersion microchannel measuring device includes a microchannel structure including a support and one or more microchannels formed in the support and each having a sample detection layer with a fixed bioadhesive material for detecting a sample, a sample injection unit configured to inject a buffer solution containing the sample into the microchannel, a prism unit having a first prism and a second prism and formed by connecting a vertical surface of the first prism and a vertical surface of the second prism, a blocking part provided in a portion where the first prism and the second prism are connected to each other, the blocking part being configured to block an optical path, a polarized light generating unit configured to generate polarized light, and a polarized light detecting unit configured to detect a polarization change of reflected light.
Owner:KOREA RES INST OF STANDARDS & SCI

Biological chip screening method of therapeutic agent based on intestinal brain axis regulation and application of biological chip screening method

The invention relates to biomedical engineering, and discloses a biochip screening method of a therapeutic agent based on intestinal brain axis regulation and application thereof. The screening method comprises the following steps: performing intestinal wall cell culture or microglial cell culture by adopting a metasurface plasmon resonance biochip of which the surface is subjected to bionic treatment to obtain an intestinal wall cell adherent chip board or a microglial cell adherent chip board; the method comprises the following steps: adding a culture medium containing a chemotherapeutic drug or lipopolysaccharide into a cell-adherent chip board for culture I, then removing the culture medium, adding a therapeutic agent to be detected for culture II to obtain a culture solution, and detecting the cell repair effect of intestinal wall cells or microglial cells in the culture solution, and screening to obtain a therapeutic agent with a repairing effect on intestinal wall cells and / or microglial cells. The screening method can be used for efficiently and accurately screening the therapeutic agent with dual effects of intestinal regulation and neuroprotection from a plurality of therapeutic agents to be detected, and can be used for dynamically monitoring and exploring the interaction condition of the therapeutic agent and cells on line in an unmarked and real-time manner.
Owner:NANJING NORMAL UNIVERSITY

Method and apparatus for determining the refractive power of an optically transparent article

The present invention relates to a method and apparatus for determining the refractive power of an optically transparent article (2), and preferred uses thereof. The refractive power of the article (2) in a first deflection direction (AH) and at least one other deflection direction (AV) in a measurement area (MB) is measured by an optical measuring device (4), defining the orientation and position of the article (2), the viewpoint (42, 52), and the line of sight direction (BR). The intersection of the defined line of sight direction (BR) and one local measurement area (MF[i]) on the article (2) and the visual angle (ε) formed by the line of sight direction (BR) and the measurement direction (MR) within the confirmed local measurement area (MF[i]) are confirmed. For the refractive power, an amplification constant is determined based on the identified visual angle (ε) and the refractive index (n) of the article (2), and the refractive power in the line of sight direction (BR) is confirmed by applying the amplification constant to the local refractive power value B[i] of the local measurement area (MF[i]).
Owner:ISRA VISION GMBH

Interferometry method and interferometry apparatus

The present invention provides an interference measurement method and apparatus that can appropriately measure the physical properties of a sample in a non-contact manner. [Solution] The interference measurement method using the interference measurement device 1 includes: a first step of obtaining a first interference waveform W1 for each optical path length difference in the first state by performing measurements while changing the optical path length difference between the first optical path P1 and the second optical path P2 in a first state in which no sample S is placed in the second optical path P2; a second step of converting the first interference waveform W1 into a first electric field amplitude waveform WE1; a third step of obtaining a second interference waveform W2 for each optical path length difference in the second state by performing measurements while changing the optical path length difference in a second state in which a sample S is placed in the second optical path P2; a fourth step of converting the second interference waveform W2 into a second electric field amplitude waveform WE2; and a fifth step of obtaining measured values ​​regarding the physical properties of the sample S based on the electric field amplitudes corresponding to the peaks of the first electric field amplitude waveform WE1 and the second electric field amplitude waveform WE2, respectively.
Owner:HAMAMATSU PHOTONICS KK

Label-free alpha-synuclein aggregate detection assay

Provided herein is a method comprising: binding α-synuclein to a biolayer interferometry (BLI) microprobe, contacting the BLI microprobe with a biological sample, contacting the BLI microprobe with α-synuclein, and measuring an optical signal from the BLI microprobe, wherein the optical signal indicates whether α-synuclein aggregates have formed on the microprobe.
Owner:THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIV