The invention relates to a novel temperature / PH dual-sensibility self-
assembly segmented
copolymer, i.e. polyhistidine-polylactic-co-
glycolic acid-polyethyleneglycol-polylactic-co-
glycolic acid-polyhistidine (OLH-b-
PLGA-b-PEG-b-
PLGA-b-OLH), belonging to the technical field of
medicine. The self-
assembly segmented
copolymer accords with the structural features of a temperature / PH unika
polymer, and a molecular structure of the self-
assembly segmented
copolymer respectively comprises a polylactic-co-
glycolic acid-polyethyleneglycol-polylactic-co-glycolic acid (
PLGA-b-PEG-b-PLGA)
chain link which responds to temperature change and a low polyhistidine
chain link which responds to PH change; copolymers can be dissolved into water under
room temperature to form a free-pouring micellar solution,and when the temperature and the PH of an external environment change, the copolymers with different structural proportions are respectively expressed as follows: (1) the
phase variation of solution-
gelatin, and (2) the response action of the dissociation of a micellar structure, wherein the copolymer with the response action of the (1) can be taken as a carrier of an injection type sustained controlled-release
drug delivery system, and the copolymer with the response action of the (2) can be taken as a carrier of a micellar
target drug delivery system.