69 results about "Non-covalent interactions" patented technology

The invention discloses a synthesis method and application of a non-condensed ring electron acceptor, which are different from a traditional condensed ring structure or a single alkyl chain side chain, and a dichlorobenzene unit is introduced as a conformation regulating group. As chlorine atoms have strong electronegativity and proper atomic radius, remarkable non-covalent interaction such as Cl-S and Cl-pi can be generated among molecules. The interaction is similar to a set of precise molecular guide rails, molecules are guided to perform highly ordered pi-pi accumulation, so that electron cloud overlapping is remarkably enhanced, and an efficient electron transmission channel is constructed. According to the organic solar cell prepared based on the non-condensed ring electron acceptor material designed by the invention, the electron mobility is remarkably improved, and meanwhile, the charge recombination loss of a device is effectively reduced.

This invention relates to a hyaluronic acid composite hydrogel based on the supramolecular self-assembly of natural molecules and its preparation method, belonging to the field of gel formulation technology. The invention first involves the self-assembly of specific natural molecules or their derivatives possessing hyaluronidase inhibitory and anti-inflammatory activities into stable supramolecular self-assemblies through intermolecular non-covalent interactions. Subsequently, this supramolecular self-assembly is combined with hyaluronic acid through various interactions such as physical entanglement, hydrogen bonding, van der Waals forces, or appropriate chemical cross-linking to construct a composite hydrogel with a uniform internal structure and stable performance. This invention not only achieves long-term, controllable sustained release of natural active ingredients in the gel through supramolecular loading, continuously inhibiting hyaluronidase activity and local inflammatory responses, but also avoids the residual risks associated with high dosages of traditional chemical cross-linking agents, ultimately obtaining a high-quality product that meets the appearance and performance requirements of medical hyaluronic acid gels.

This invention discloses a magnetic covalent organic framework composite material modified with nucleic acid aptamers, its preparation method, and its applications. The composite material uses magnetic iron oxide microspheres as the core, with the surface of the core coated with a shell of covalent organic framework material. Nucleic acid aptamers capable of specifically recognizing tetracycline antibiotics are stably assembled onto the shell surface through non-covalent interactions. This invention fully utilizes the large specific surface area and electron-rich framework of magnetic covalent organic framework materials as efficient carriers for nucleic acid aptamers, effectively overcoming the shortcomings of traditional adsorption materials in terms of poor selectivity and limited adsorption capacity in complex matrices, while avoiding cumbersome covalent modification processes. This composite material exhibits excellent adsorption capacity and superior selectivity for tetracycline antibiotics, and is particularly suitable for rapid and efficient magnetic solid-phase extraction of trace tetracycline antibiotics in complex animal-derived food matrices, significantly improving the detection sensitivity and accuracy of subsequent instrumental analysis.

This invention relates to a mixed solvent-induced highly fluorescent silver nanoclusters, its preparation method, and its application in LEDs. These highly fluorescent silver nanoclusters are formed by the self-assembly of Ag6 in a mixed solvent of water and NMP through non-covalent interactions such as hydrogen bonding and π-π / π* interactions. Due to the restriction of ligand rotation and vibration, the silver nanoclusters exhibit significant fluorescence properties, with fluorescence intensity reaching 10⁻⁶. 7 The fluorescence lifetime is 11.77 μs and the quantum yield is 17.57%. The method for preparing high-fluorescence silver nanoclusters of the present invention is simple and inexpensive; when mixed with commercial phosphors, it can modulate white LEDs and can be used as a light conversion material for environmentally friendly WLEDs.

The invention relates to a supramolecular self-assembly hydrophobic surfactant as well as a preparation method and application thereof, and belongs to the technical fields of supramolecular self-assembly, surface modification engineering and hydrophobic coatings. The surfactant comprises a fluorine-containing compound and absolute ethyl alcohol, and the fluorine-containing compound is self-assembled in the absolute ethyl alcohol to form uniformly dispersed nano small particles; the fluorine-containing compound is obtained by reacting 4-aldehyde imidazole with hexamethylene diisocyanate and then grafting the reaction product on 1H, 1H, 2H, 2H-perfluoro-1-alcohol. Self-assembly in absolute ethyl alcohol is achieved through non-covalent interaction of fluorine-containing compounds, a nano-scale lotus leaf bionic structure is constructed, and the nano-structure material has hydrophobicity and also has a lotus leaf-imitated microcosmic hydrophobic structure and has good hydrophobicity. And when the catalyst is used for Al surface modification, the hydrophobic protection performance of Al can be improved, and a large number of active sites are reserved.

Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.

This invention discloses a ternary composite foaming agent of flaxseed protein-fucose-rutin, its preparation method, and its application in meringue cookies. The foaming agent is a non-covalent complex formed by flaxseed protein isolate (FPI), fucoidan (FUC), and rutin (RU) through electrostatic interactions, hydrogen bonds, and hydrophobic interactions, with a mass ratio of FPI:FUC:RU = 1:2:(0.2~0.4). This invention forms a structurally stable composite system through the non-covalent interactions of FPI, FUC, and rutin, achieving a foaming height of 95.69±8.77%. The foam retention rate after 30 minutes is more than double that of natural FPI, and the interfacial tension is reduced to below 25 mN / m, overcoming the shortcomings of poor foaming properties and insufficient stability of single plant proteins. Even after high-temperature baking, the foam retention rate remains above 75%, meeting the processing requirements of meringue cookies.

The invention discloses a protein ligand binding affinity prediction method based on two-channel hierarchical interactive learning, and particularly relates to an affinity prediction method based on two-channel hierarchical interactive learning. The method comprises the following steps: S1, based on a protein-ligand compound space structure containing a three-dimensional structure and chemical data, constructing six chemical entity interaction diagram networks from an atomic scale to a substructure scale; s2, extracting covalent and non-covalent interaction information of protein-ligands from the internal and external channels at the same time by taking a dual-channel coding framework as a backbone; and S3, adopting a hierarchical interactive learning strategy. According to the affinity prediction method based on the two-channel hierarchical interactive learning, provided by the invention, understanding of protein-ligand complex interaction is enhanced through a technology of modeling richness and complexity of protein-ligand interaction information, so that the protein-ligand binding affinity is comprehensively and accurately predicted.

Described are affinity purification system that includes a carrier / surface that is non-cellular, and sliding clamp (SC) protein, and methods for purifying proteins that bind to the SC. The SC is associated with the carrier / surface via covalent / non-covalent interactions. To attain control of coupling site, the SC can be mutated via site-directed mutagenesis to introduce an exogenous residue and, the exogenous internal residue is conjugated to the non-cellular surface through the linker. The SC can also be coupled to the carrier via non-covalent interactions such as the affinity interactions involved in ligand / binding partner complex formation.The SC-based affinity purification system are used in a purification column as bait proteins, to isolate SC binding partners or non SC-binding proteins engineered to contain a SC binding site prior to its purification.

The invention belongs to the technical field of environmental restoration, and particularly relates to cyclodextrin cross-linked supramolecular hydrogel as well as a preparation method and application thereof. A construction unit of the supramolecular hydrogel comprises double-bond modified beta-cyclodextrin and acrylic acid interacting with the double-bond modified beta-cyclodextrin through a covalent bond; plant hormones are included in a cavity of the double-bond modified beta-cyclodextrin. The supramolecular hydrogel adhesive tape is provided with charges and cavities, can include plant hormones, and can be used together with soil improvement plants such as green manure to enhance the saline-alkali soil improvement effect by regulating and controlling the salinity of plant rhizosphere soil, improving the emergence rate, promoting plant growth and improving the environmental stress resistance of the plants. Cavities of the double-bond modified beta-cyclodextrin can effectively include plant hormones, and the supramolecular hydrogel is formed through covalent interaction between the acrylic acid and the double-bond modified beta-cyclodextrin. Based on multi-covalent and non-covalent interaction, the supramolecular hydrogel has the advantage of controllably releasing plant hormones, and realizes sustainable environmental remediation by cooperating with plant remediation.

The application belongs to the technical field of water body remediation, and particularly relates to a method for removing heavy metals in water bodies by using supramolecular hydrogel. The supramolecular hydrogel used in the application is amino clay and carboxymethyl beta-cyclodextrin supramolecular hydrogel. The supramolecular hydrogel used in the application has charges and a porous structure, can produce adsorption on heavy metal ions, and can remove heavy metal ions in water bodies, has high environmental remediation efficiency, has a short remediation period, and has a water body heavy metal ion removal rate of more than 99% at 14 days. The supramolecular hydrogel used in the application has high-performance capture of chemical pollutants based on the porous structure and orthogonal non-covalent interaction-electrostatic interaction, and can be an efficient platform for sustainable water body environmental remediation.

Disclosed herein is a modified oligonucleotide, the modified oligonucleotide comprises one or more modifications in at least one of a phosphate backbone, a nucleobase, or a sugar. The one or more modifications impede translocation through a nanopore by increasing non-covalent interactions with the interior of the nanopore or the lipid bilayer that supports the nanopore, increasing the bulk size or the steric hinderance of oligonucleotide, or alter the charge density of the oligonucleotide.

The application provides a platelet-responsive self-gelation hemostatic material and a preparation method and application thereof, and belongs to the medical field. Based on a multiple cross-linking strategy of dynamic covalent bonds and non-covalent interactions, a hemostatic material capable of realizing self-gelation quickly is designed by using modified sodium alginate and hydroxylated porcine small intestinal submucosa as raw materials. The hemostatic material has good hydrophilicity and liquid absorption capacity, can realize powder-gelation transformation in a short time, form a stable physical barrier, has platelet response characteristics, can promote platelet adhesion and activation, accelerate the blood coagulation process of the body, and improve the mechanical properties and tissue adhesion of the material, and has a good application prospect.

This invention discloses a method and system for training and identifying non-covalent interaction models. The identification method includes: acquiring the spatial structure information of the molecular structure to be identified; inputting the spatial structure information of the molecular structure to be identified into an identification model based on a preset electron density; and generating the position coordinates and topological features of non-covalent interactions in the molecular structure to be identified through the identification model. The technical solution provided by this invention solves the problem of inaccurate identification of non-covalent interactions in molecular systems.

The invention belongs to the technical field of adhesives, and particularly relates to an adhesive as well as a preparation method, application and a use method thereof. According to the method, bamboo wood is disintegrated to obtain an extract with lignin as a main component, and the extract and cellulose are assembled through non-covalent interaction to construct the adhesive; the obtained adhesive is adhered to a base material in a high-temperature hot pressing manner, so that the use of toxic reagents such as formaldehyde is avoided while high-strength adhesion is realized. The adhesive obtained by the invention can stably bond wood and various substrates, is waterproof, formaldehyde-free, green and environment-friendly, and the preparation method is simple and does not need precious precise instruments.

This invention relates to the field of medical materials technology, providing a hydrogel containing antler mesenchymal stem cell exosomes, its preparation method, and applications. The method includes the following steps: preparation of antler mesenchymal stem cell exosomes; preparation of PVP-HA composite hydrogel; uniformly mixing AMSC-Exos with a hydrogel precursor solution, and forming a hydrogel containing antler mesenchymal stem cell exosomes through physical embedding and non-covalent interactions. This invention utilizes the three-dimensional porous network structure of the hydrogel to achieve long-term sustained release of exosomes, protecting them from rapid degradation; it leverages the unique regenerative advantages of antler-derived exosomes to synergistically promote angiogenesis, inhibit inflammatory responses, and regulate macrophage polarization; it promotes angiogenesis through the miR-486-5p / FGF9 axis, achieving efficient repair of chronic diabetic wounds; and it provides a novel, efficient, safe, and clinically translational strategy for the treatment of chronic diabetic skin lesions.

The application discloses a preparation method and application of a nano self-assembly composition of arbutin-berberine, and comprises the following steps: dissolving berberine in methanol at 38-42 DEG C, adding an arbutin super-pure water solution at 38-42 DEG C, and stirring and keeping warm for 0.8-1.2 h to obtain a self-assembly solution; then, the self-assembly solution is subjected to vacuum rotary evaporation and freeze drying in sequence, and the nano self-assembly composition of arbutin-berberine is obtained. The traditional Chinese medicine nano self-assembly system based on arbutin and berberine is successfully constructed, the nanoparticles are spontaneously formed under mild conditions through intermolecular non-covalent interaction, the preparation process is simple and convenient, the conditions are mild, the damage of high temperature and other harsh conditions to active ingredients is effectively avoided, and the process adaptability is high.

The invention discloses a fluorinated metal organic framework material as well as a preparation method and application thereof, and belongs to the technical field of metal organic framework materials. Under the condition of room temperature, adding the deprotonation agent solution into the 2-trifluoromethylimidazole solution, uniformly mixing, and dropwise adding the zinc salt solution into the mixed solution under vigorous stirring; and after dropwise adding is finished, continuously stirring and reacting, and then standing, centrifuging, washing and drying in vacuum to obtain the fluorinated metal organic framework material. The fluorinated metal organic framework material prepared by the invention is based on an F-F non-covalent interaction mechanism, and can directly realize high-efficiency adsorption of long-chain perfluorinated and polyfluoroalkyl substances (PFAS) in a neutral water body under the condition that the salinity does not need to be adjusted. The maximum adsorption capacities of the material to PFOA (perfluorooctanoic acid), PFOS (perfluorooctanoic acid), PFNA (perfluorooctanoic acid), PFNS (perfluorooctanoic acid) and HFPO-TeA (hexafluoropropylene oxide-TeA) respectively reach 529.64 mg / g, 585.33 mg / g, 1135.18 mg / g, 1346.72 mg / g

The application discloses a high-flux fiber physiological electrode, a preparation method, an electrode array and application thereof, and belongs to the field of flexible electronics and biomedical sensing. The electrode adopts a three-layer coaxial fiber structure, the inner layer is a high-conductivity core layer containing MXene, carbon nanotubes and poly 3,4-ethylenedioxythiophene, the middle layer is an insulating layer such as polydimethylsiloxane, and the outer layer is a self-adhesive layer based on dynamic bond cross-linked polyvinyl alcohol and polyacrylic acid. The diameter of a single fiber is 50-100 mu m. By utilizing the reversible adhesion characteristics of the outer layer dynamic bond and / or non-covalent interaction, multiple fibers can be freely assembled into a high-density and reconfigurable electrode array. The array has excellent electrochemical performance, mechanical matching, interface adhesion stability and biocompatibility, and has a stimulation response and self-healing ability, is suitable for long-term stable wearable physiological monitoring and implantable closed-loop neural interface, and can realize high spatiotemporal resolution bioelectric signal recording and regulation.

The invention belongs to the technical field of pest control, and relates to application of an azo compound as an arginine kinase inhibitor and prevention and control of ampullaria gigas. The azo compound 4-[2-(2-isopropyl-5-methylphenoxy) ethyoxyl]-3-methoxybenzaldehyde (4, 6-dipyrrolidine-1-yl-1, 3, 5-triazine-2-yl) hydrazone obtained through screening can be jointly and stably combined with arginine kinase through multiple types of non-covalent interaction, and the function of an arginine kinase inhibitor is played. When the azo compound provided by the invention is used for preventing and treating ampullaria gigas, an excellent poisoning effect is shown, the activity of the azo compound is higher than that of an existing arginine kinase inhibitor quercetin, and the azo compound is good in selectivity and low in toxicity to vertebrates compared with a traditional molluscicide metaldehyde.

Elastomer-based styrene-type block copolymer (SBC) compositions are provided. The compositions comprise one or more SBCs and one or more polymers miscible with the styrene-type end blocks of the one or more SBCs. The block copolymer compositions are physically crosslinked and chemically crosslinked, wherein the chemical crosslinking includes covalent bonds between the chains of the SBCs, and the physical crosslinking includes non-covalent interactions between the styrene-type end blocks of the one or more SBCs and the one or more polymers miscible with the styrene-type end blocks. The block copolymer compositions can be used to form impregnated articles such as surgical gloves.

The application discloses a preparation method and application of an injectable high-strength bone tissue adhesive, and belongs to the technical field of biomaterials. The hydrogel tissue adhesive comprises micron or nanometer organic particles carrying amino groups, water-soluble polymer which can be chemically crosslinked with the amino groups, and micron or nanometer inorganic particles which can promote osteogenesis; under the action of water, the hydrogel tissue adhesive can form a continuous and porous particle network, and the chemical reaction between the particles and the polymer can provide good adhesive performance, and the adhesive strength can reach 5Mpa. In addition, the non-covalent interaction between the particles can make the material better stay in the defect site, and realize the filling of the bone defect. The inorganic component in the material component of the application can release ions which can promote osteogenesis, and promote the repair of the bone defect. In addition, the hydrogel tissue adhesive can also be used as a bone wound hemostatic material and a cell scaffold material, and has a wide application prospect in the field of bone repair.

The application discloses a base recognition method based on semiconductor SERS technology and belongs to the technical field of biomedical detection. The specific method comprises the following steps: step one, synthesis of TiO2 nanoparticles; step two, preparation of a TiO2 / 4-MBA system; and step three, base recognition detection. The TiO2 / MBA system can be used for accurate and rapid DNA base recognition, and the developed TiO2 / MBA system is simple to prepare and has excellent base test performance, and has a high market application prospect. The application not only provides a novel base detection method, but also has high sensitivity and selectivity, can recognize and detect four bases and the non-covalent interaction between the four bases and 4-MBA in two pH environments, and has a simple and rapid operation process. The application not only provides a new method for base analysis, but also provides technical support for early diagnosis of DNA related diseases, genomics research and development of molecular sensors, and has a wide application prospect.

The invention discloses a gold-copper intermetallic compound superlattice array and a preparation method and application thereof. The preparation method comprises the following steps: firstly, preparing gold nanoparticles; then adding a toluene solution of oleylamine into the gold nanoparticles, mixing and oscillating, taking an upper layer oleylamine phase, and standing; dissolving copper acetylacetonate in an oleylamine solution, and adding the upper oleylamine phase for reaction to obtain gold-copper nanoparticles; and adding oleic acid into the gold-copper nanoparticles for modification to form superlattices, dropwise adding the superlattices into a diethylene glycol solution, and naturally evaporating to obtain the gold-copper intermetallic compound superlattice array. A gold-copper intermetallic compound is synthesized by adopting a high-temperature hydrothermal method, an atomic-scale long-range ordered structure is synthesized, functional molecules such as oleylamine and oleic acid are modified, a long-range ordered periodic structure is spontaneously arranged under non-covalent interaction, an electron energy band structure, carrier transport efficiency and light absorption characteristics can be regulated and controlled, and the photoelectric conversion efficiency is improved. The method has wide application potential in multiple fields.

The application discloses a kind of super amphiphilic molecule based high-performance curcumin carrier based on modular construction and its preparation method and application, belong to biotechnology field.The preparation method in which β-cyclodextrin is encapsulated curcumin by host-guest interaction, sodium caseinate is treated by alkali to expose hydrophobic group and mix with inclusion complex, resulting in the rigid macrocycle of inclusion complex and the flexible open chain of alkali-treated sodium caseinate are combined by non-covalent interaction to form super amphiphilic molecule, then part of curcumin is added to interact with uncombined hydrophobic sites, after stirring and ultrasonic, use citric acid to adjust back to neutral induction system to assemble into nanoparticles, add maltodextrin and process by stirring, centrifugation, spray drying etc.The curcumin carrier prepared by the application has excellent water solubility, high stability, good powder physical properties, high bioavailability, simple process production, and has great commercial value.

This invention discloses an inverse perovskite solar cell and its fabrication method that utilizes a tetrathiofulvalene derivative to regulate the self-assembled monolayer (SAM) assembly structure. The invention uses bis(carbazolium phosphate) SAM-4PABCz as the hole-selective interface layer, employs an ethanol / NMP mixed solvent system, and introduces a tetrathiofulvalene (TTF) derivative as a dopant. By leveraging the steric hindrance effect and non-covalent intermolecular interactions of the TTF derivative, the out-of-plane π-π interactions between bis(carbazolium phosphate) molecules are weakened, inducing the molecules to shift from a high-tilt-angle "standing" stacking of SAM molecules to a low-tilt-angle near-flat arrangement. This regulation strategy effectively suppresses island-like aggregation of SAMs, reduces the interface defect state density, promotes uniform and ordered molecular stacking, and forms a uniform and dense hole-selective contact interface.

This invention discloses a vitamin A-functionalized polyphenol-phospholipid complex, its preparation method, and its applications, belonging to the field of pharmaceutical formulation and nanodelivery technology. The phospholipid complex comprises a polyphenol drug, a phospholipid material, and a vitamin A phospholipid ligand. The vitamin A phospholipid ligand is formed by vitamin A or its derivatives and a phospholipid derivative containing amino or other reactive groups. The phospholipid complex forms a phospholipid composite structure through non-covalent interactions between the polyphenol drug and the phospholipid material, and the vitamin A phospholipid ligand is inserted into or assembled into the surface or interior of the phospholipid composite structure. Animal experiments show that this phospholipid complex can reduce serum transaminase levels and alleviate the degree of liver fibrosis, and has good blood compatibility and tissue safety. This invention provides an industrially achievable targeted nano-formulation solution for early intervention in liver fibrosis, with promising application prospects.

The present invention belongs to the technical field of hydrogels. Disclosed are hydrogel microspheres, a preparation method therefor, and use thereof. According to the present invention, epigallocatechin gallate and vitamin E are self-assembled into a hydrophobic polyphenol-based micelle, wherein the hydrophobic polyphenol-based micelle, with EGCG as the core, forms a stable structure by means of non-covalent interactions (such as hydrophobic interactions, hydrogen bonding, and π-π stacking), thereby enhancing the stability and functionality of the hydrophobic core. Then, the hydrophobic structure is mixed with hydrophilic sodium alginate to form a gel, ultimately resulting in hydrogel microspheres with a unique amphiphilic heterogeneous structure. The hydrogel microspheres can exist stably in an aqueous environment, and actively capture dietary fats, thereby improving the ability to capture dietary fats, and improving the stability of the hydrogel microspheres in the gastrointestinal tract.

The invention discloses a structure-directing agent for guiding ordered stacking of nanosheets and application of the structure-directing agent, and aims to solve the problems that in the prior art, directional arrangement of the nanosheets is difficult to effectively guide, and a highly ordered ion transmission channel cannot be constructed. The structure-directing agent for guiding ordered stacking of nanosheets has a chemical formula structure of A-B-C, in which the A unit is alkyl or alkoxy of C4-C18; the unit B is a linear rigid framework formed by directly connecting two or three six-membered aromatic rings through a single bond; and the C unit is a cyano group or a fluorine atom. And adding the structure-directing agent into a nanosheet dispersion liquid, and carrying out vacuum filtration and drying to obtain the nano composite film. According to the structure-directing agent disclosed by the invention, non-covalent interaction is generated between the structure-directing agent and the nanosheets through an amphiphilic structure of the structure-directing agent, so that ordered stacking of various nanosheets is guided. The obtained nano composite membrane is used as an ion selective separation membrane, and the output power density in a 0.5 M / 0.01 M NaCl solution is not lower than 5.0 W / m.

The invention provides a platelet response type self-gelation hemostatic material as well as a preparation method and application thereof, and belongs to the field of medicines. Based on multiple cross-linking strategies such as dynamic covalent bonds and non-covalent interaction, modified sodium alginate and hydroxylated pig small intestine submucosa are used as raw materials, and the hemostatic material capable of rapidly achieving self-gelation is designed. The hemostatic material has good hydrophilicity and liquid absorption capacity, can realize powder-gelation conversion in a short time to form a stable physical barrier, has platelet response characteristics, can promote platelet adhesion, activate and accelerate the coagulation process of an organism, and improves the mechanical properties and tissue adhesion of the material, so that the hemostatic material has good application prospects. Good application prospects are realized.