212 results about "Non-covalent interactions" patented technology

The invention discloses a probiotic-polyphenol nanoparticle colon-targeted co-delivery system as well as a preparation method and application thereof, and belongs to the field of biological medicines. The FCPs and hyaluronic acid (HA) are combined through non-covalent interaction, so that the hydrogel has colon targeting property and mucosal adhesion at the same time, and delivery of probiotics is facilitated. The hydrogel (HF) based on polysaccharide has good biocompatibility, and can be used for effectively encapsulating the probiotics and the natural products. Then, the PDA-TH NPs and BA are incorporated into the polysaccharide chain network of HF, and finally the BA-HF-PDAT targeted co-delivery system is constructed. The BA (at) HF-PDAT targeted co-delivery system can protect BA from serious gastrointestinal stress, and is jointly assembled with PDT-TH NPs to realize dual slow release of thymol (Thy), so that the treatment effect of BA and Thy is improved, and the BA (at) HF-PDAT targeted co-delivery system contributes to treatment of clostridium difficile infection (CDI).

The invention discloses a beta-lactoglobulin fluorescent probe as well as a preparation method and application thereof, the structural formula of the probe is (C30H25N4I), the probe is combined with beta-lactoglobulin through non-covalent interaction, a fluorescence signal is triggered to be remarkably enhanced, and low-background fluorescence detection of the beta-lactoglobulin is realized. The probe has low cytotoxicity and excellent mitochondrial targeting ability, and provides a powerful tool for visualization of beta-lactoglobulin in living cells. After being combined with beta-lactoglobulin, a sample can generate obvious color change under the irradiation of an ultraviolet lamp, and the change can be used for evaluating the content of active beta-lactoglobulin in the sample, so that the rapid detection of the milk protein level in a beverage is realized. The beta-lactoglobulin fluorescent probe disclosed by the invention has a wide application prospect in the fields of biological imaging, milk protein detection, beverage quality control and the like.

The invention belongs to the technical field of pharmaceutical preparations, and relates to traditional Chinese medicine self-assembled nanoparticles for enhancing anti-inflammatory activity as well as a preparation method and application of the traditional Chinese medicine self-assembled nanoparticles. The traditional Chinese medicine self-assembled nanoparticles are prepared from biphenyl cyclooctene type lignan and an oleanane type pentacyclic triterpenoid compound, wherein the mass ratio of the biphenyl cyclooctene type lignan to the oleanane type pentacyclic triterpenoid compound is 1 to (0.125 to 8). Through an anti-solvent exchange method, the carrier-free nanoparticles based on self-assembly of the traditional Chinese medicine active ingredients are prepared by utilizing spontaneous non-covalent interaction between the biphenyl cyclooctene lignan and the oleanane pentacyclic triterpenoid, so that the cytotoxicity is remarkably reduced, the biocompatibility is enhanced, and the toxic and side effects are reduced; meanwhile, the traditional Chinese medicine self-assembled nano-particles have a remarkable cellular uptake effect, the absorption and utilization efficiency of the medicine is improved, and more efficient anti-inflammatory biological activity is shown.

The invention belongs to the technical field of emulsion materials, and particularly relates to metal-polyphenol network modified coconut protein composite particles as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing a coconut protein-pectin compound by taking coconut protein and pectin as raw materials, adding a tannic acid solution into the coconut protein-pectin compound, mixing, adding a Fe < 3 + > solution, and mixing to obtain metal-polyphenol network modified coconut protein composite particles; according to the preparation method, tannic acid and the coconut protein-pectin compound are subjected to non-covalent interaction, Fe < 3 + > and phenolic hydroxyl groups on the tannic acid are subjected to coordination reaction, a metal-polyphenol network is formed through cross-linking of Fe-O coordination bonds, and a compact modification layer is constructed on the surface of the coconut protein-pectin compound, so that on one hand, waste coconut protein resources are utilized; on the other hand, the problem that composite particles prepared from pectin and coconut protein are prone to depolymerization is solved, the structural stability is improved, and meanwhile iron and polyphenol are supplemented.

The invention discloses an intermolecular interaction conformation generation method and device based on electrostatic potential matching, and relates to the field of theory and computational chemistry, and the method comprises the steps: calculating a 3D conformation of a set molecule through a quantum chemistry strategy to obtain wave function information of a molecular system; calculating the set molecules according to the electron density value to obtain the electron density value of the set molecules; constructing Van der Waals surfaces of the set molecules by constructing a contour surface strategy; by setting a potential calculation strategy, calculating electrostatic potential values of grid points on the set molecule Van der Waals surface; through setting an orientation confirmation strategy, determining mutual approaching orientations of a plurality of set molecules in pairs; 3D conformations of a plurality of set molecules are obtained by setting a public data set or geometric structure optimization processing, and the non-covalent interaction conformation is formed by splicing every two set molecules through a set splicing strategy according to the orientation that every two set molecules are close to each other. According to the method, the intermolecular non-covalent interaction conformation can be quickly and accurately obtained.

The invention discloses a phenoxazine derivative as well as a preparation method and application thereof, and belongs to the field of biological medicine synthesis. A series of phenoxazine derivatives are synthesized by using a simple, efficient and low-toxicity method, circular dichroism, fluorescence spectrum and ultraviolet absorption spectrum prove that the molecules not only have non-covalent interaction with DNA, but also can be subjected to transamidation reaction with the DNA to covalently modify the DNA, and meanwhile, the phenoxazine derivatives are relatively good in anti-tumor cell activity and relatively good in anti-tumor effect. And a new strategy is provided for the research of DNA targeted drugs.

Disclosed is a novel strategy for engineering tissue adhesives in which molecular building blocks are manipulated to allow for precise control and optimization of the various aforementioned properties without any tradeoffs. To introduce tunable mechanical properties and robust tissue adhesion, the hydrogel network presents different modes of covalent and noncovalent interactions using N-hydroxysuccinimide ester (NHS) conjugated alginate (Alg-NHS), poly (ethylene glycol) diacrylate (PEGDA), tannic acid (TA), and Fe3+ ions. Through combining and tuning different molecular interactions and a variety of crosslinking mechanisms, we were able to design an extremely elastic (924%) and tough (4697 kJ / m3) multifunctional hydrogel that could quickly adhere to wet tissue surfaces within 5 sec of gentle pressing and deform to support physiological tissue function over time under wet conditions.

The invention discloses a symmetric nucleoside microneedle patch loaded with polymer vesicles as well as a preparation method and application of the symmetric nucleoside microneedle patch. The symmetric nucleoside microneedle patch loaded with the polymer vesicles comprises a guanosine-quadruplex hydrogel microneedle tip doped with drug-loading polymer vesicles, the raw material of the drug-loaded polymer vesicle comprises a polycaprolactone-polyglutamic acid copolymer; the guanosine-quadruplex hydrogel is prepared from the following raw materials: guanosine and KB (OH) 4. The microneedle patch is constructed on the basis of dynamic covalent bond and non-covalent interaction, has a sharp tip array capable of penetrating the epithelium and the lower layer of a mucous membrane, can efficiently deliver a drug to a canker lesion part by bypassing a mucous membrane barrier, can be controllably broken under a high ROS condition of an inflammation microenvironment, has the characteristics of high drug delivery efficiency and high accuracy, and can be used for preparing a medicine for treating the canker lesion part. The effect of effectively improving chemotherapy-induced oral ulceration can be achieved by reducing inflammatory response, relieving pain feeling and inhibiting pain sensitization.

The invention provides a polyurethane urea elastomer, a preparation method and application thereof, and an ionic conductive elastomer, and belongs to the field of polymer materials. A soft-segment substance, isocyanate and a catalyst are subjected to a prepolymerization reaction to obtain a prepolymer, the prepolymer, a chain extender and an organic solvent are subjected to a chain extension reaction to obtain the PUU elastomer, the soft-segment substance contains hydroxyl, and the chain extender contains phenyl and a bishydrazide substituent. According to the invention, PUU is synthesized by a chain extender simultaneously containing phenyl and a bishydrazide substituent, the phenyl in the PUU can be assembled in situ based on pi-pi interaction to form an aggregate, and the aggregate and multiple hydrogen bonds between amido urea bonds on two sides of the aggregate jointly form a double-lock hard domain which has high binding energy and is cross-linked based on non-covalent interaction in the PUU. The unique structure of PUU improves the mechanical properties, including strength, elasticity and tear resistance, of the material on one hand, and endows the material with a function of repairing mechanical damage on the other hand.

The invention belongs to the technical field of hydrogel, and discloses hydrogel microspheres as well as a preparation method and application thereof. According to the invention, epigallocatechin gallate and vitamin E are self-assembled into hydrophobic polyphenol-based micelles, the hydrophobic polyphenol-based micelles take EGCG as a core, a stable structure is formed through non-covalent interaction (such as hydrophobic interaction, hydrogen bond and pi-pi accumulation), and the stability and functionality of the hydrophobic core are enhanced; the preparation method comprises the following steps: preparing a hydrophobic structure, mixing the hydrophobic structure with hydrophilic sodium alginate for gelling to finally obtain the hydrogel microsphere with a unique amphiphilic heterostructure, and the hydrogel microsphere can stably exist in a water environment, actively captures dietary fat, improves the capture capability on the dietary fat, and improves the dietary fat capture efficiency. The stability of the hydrogel microspheres in gastrointestinal tracts is improved.

Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component. Printed parts having piezoelectric properties may be formed using compositions comprising a plurality of piezoelectric particles non-covalently interacting with at least a portion of a polymer material via π-π bonding, hydrogen bonding, electrostatic interactions stronger than van der Waals interactions, or any combination thereof. The piezoelectric particles may be dispersed in the polymer material and remain substantially non-agglomerated when combined with the polymer material. The polymer material may comprise at least one thermoplastic polymer, optionally further including a polymer precursor. The compositions may define an extrudable material that is a composite having a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes using the compositions may comprise forming a printed part by depositing the compositions layer-by-layer.

The invention provides styptic powder based on tannic acid modified gelatin as well as a preparation method and application of the styptic powder. The modified gelatin is a compound formed by chemically crosslinking and blending tannic acid and pre-crosslinked gelatin, the tannic acid can be uniformly distributed in a gelatin network, and the tannic acid serving as an exogenous hemostatic active substance can be subjected to rapid non-covalent interaction such as H bonds and pi-pi stacking with proteins in blood to form microclots; gelatin particles are promoted to rapidly infiltrate blood and settle, so that aggregation of platelets and red blood cells is accelerated, and gelatin can accelerate activation of an endogenous hemostasis pathway, so that a synergistic effect is formed, and rapid hemostasis is realized. In addition, tannic acid also has good antibacterial activity, wound infection after hemostasis can be effectively avoided, and the tannic acid is especially suitable for emergency hemostasis in outdoor first aid.

The invention discloses a preparation method of a polysulfide ionic conductor, which efficiently generates ionic conductors with various performances and complex structures through rapid polymerization of polysulfide, and overcomes the contradiction between the complex structure and efficient manufacturing in a polymer ionic conductor. The mechanical property and conductivity of the polysulfide ionic conductor are regulated and controlled by utilizing a copolymerization strategy, the ionic liquid and the lithium salt, the comonomers involved in the invention are rich in variety, the generated polymer is diversified in structure and adjustable in performance, synchronous improvement of the mechanical property and the ionic conductivity in the ionic conductor is realized, and the polysulfide ionic conductor can be suitable for various ionic electric devices. The scheme is simple in process and high in atom utilization rate, meets the requirements of green chemistry, and has practical industrial feasibility. The polysulfide ionic conductor has abundant dynamic covalent bonds (such as disulfide bonds) and non-covalent interactions (such as hydrogen bonds and lithium bonds), so that the synthesized ionic conductor can be self-repaired, degraded and recycled, and the service life and life cycle of the material are prolonged.

The invention discloses a synthesis method and application of a non-condensed ring electron acceptor, which are different from a traditional condensed ring structure or a single alkyl chain side chain, and a dichlorobenzene unit is introduced as a conformation regulating group. As chlorine atoms have strong electronegativity and proper atomic radius, remarkable non-covalent interaction such as Cl-S and Cl-pi can be generated among molecules. The interaction is similar to a set of precise molecular guide rails, molecules are guided to perform highly ordered pi-pi accumulation, so that electron cloud overlapping is remarkably enhanced, and an efficient electron transmission channel is constructed. According to the organic solar cell prepared based on the non-condensed ring electron acceptor material designed by the invention, the electron mobility is remarkably improved, and meanwhile, the charge recombination loss of a device is effectively reduced.

The invention discloses a drawing rope type supramolecular subject-guest as well as a preparation method and application of the drawing rope type supramolecular subject-guest. The construction unit of the drawing rope type supramolecular subject-object is an assembly constructed by taking a structure as shown in a formula I as a subject macroring and a structure as shown in a formula II as a guest molecule through non-covalent interaction. The drawing rope type supramolecular host-guest is high in thermal stability and can resist high temperature, mechanical properties of a polymer in the aspects of hardness, toughness and strength can be comprehensively improved by adding the drawing rope type supramolecular host-guest into a polymerizable system, and regulation and control of the mechanical properties of the polymer can be achieved by changing the proportion of host macrocycles to guest molecules. Therefore, the functional polymer with various mechanical properties is obtained.

This invention relates to a hyaluronic acid composite hydrogel based on the supramolecular self-assembly of natural molecules and its preparation method, belonging to the field of gel formulation technology. The invention first involves the self-assembly of specific natural molecules or their derivatives possessing hyaluronidase inhibitory and anti-inflammatory activities into stable supramolecular self-assemblies through intermolecular non-covalent interactions. Subsequently, this supramolecular self-assembly is combined with hyaluronic acid through various interactions such as physical entanglement, hydrogen bonding, van der Waals forces, or appropriate chemical cross-linking to construct a composite hydrogel with a uniform internal structure and stable performance. This invention not only achieves long-term, controllable sustained release of natural active ingredients in the gel through supramolecular loading, continuously inhibiting hyaluronidase activity and local inflammatory responses, but also avoids the residual risks associated with high dosages of traditional chemical cross-linking agents, ultimately obtaining a high-quality product that meets the appearance and performance requirements of medical hyaluronic acid gels.

This invention discloses a magnetic covalent organic framework composite material modified with nucleic acid aptamers, its preparation method, and its applications. The composite material uses magnetic iron oxide microspheres as the core, with the surface of the core coated with a shell of covalent organic framework material. Nucleic acid aptamers capable of specifically recognizing tetracycline antibiotics are stably assembled onto the shell surface through non-covalent interactions. This invention fully utilizes the large specific surface area and electron-rich framework of magnetic covalent organic framework materials as efficient carriers for nucleic acid aptamers, effectively overcoming the shortcomings of traditional adsorption materials in terms of poor selectivity and limited adsorption capacity in complex matrices, while avoiding cumbersome covalent modification processes. This composite material exhibits excellent adsorption capacity and superior selectivity for tetracycline antibiotics, and is particularly suitable for rapid and efficient magnetic solid-phase extraction of trace tetracycline antibiotics in complex animal-derived food matrices, significantly improving the detection sensitivity and accuracy of subsequent instrumental analysis.

The invention provides an SPI-CS-EGCG ternary complex as well as a preparation method and application thereof. The preparation method of the ternary complex comprises the following steps: respectively preparing an SPI solution, a CS solution and an EGCG solution; adjusting the pH value of the SPI solution, and heating to obtain SPI microgel; the SPI microgel and a CS solution are mixed and stirred, and an SPI-CS mixed solution is obtained; and mixing and stirring the SPI-CS mixed solution and the EGCG solution, and centrifuging to obtain the SPI-CS-EGCG ternary complex. According to the SPI-CS-EGCG ternary complex, the functional characteristics of SPI are remarkably improved through non-covalent interaction (hydrogen bonds, hydrophobic interaction and Van der Waals' force), and the SPI-CS-EGCG ternary complex has good thermal stability, rheology and tribology characteristics, so that the SPI-CS-EGCG ternary complex has wide application prospects in the food industry.

The present invention relates to a nucleic acid-based assembly comprising: at least one nucleic acid aptamer, and at least one nucleic acid motif designed to physically capture a drug. The nucleic acid motif may comprise one or more photo-responsive moieties that effect the release of the drug upon irradiation. The aptamer and the nucleic acid motif each can be covalently linked to one or more lipids, and the lipid-modified aptamer and nucleic acid motif may form the assembly through noncovalent interaction. The invention further relates to use of the nucleic acid-based assembly in the treatment of cancer.

This invention relates to a mixed solvent-induced highly fluorescent silver nanoclusters, its preparation method, and its application in LEDs. These highly fluorescent silver nanoclusters are formed by the self-assembly of Ag6 in a mixed solvent of water and NMP through non-covalent interactions such as hydrogen bonding and π-π / π* interactions. Due to the restriction of ligand rotation and vibration, the silver nanoclusters exhibit significant fluorescence properties, with fluorescence intensity reaching 10⁻⁶. 7 The fluorescence lifetime is 11.77 μs and the quantum yield is 17.57%. The method for preparing high-fluorescence silver nanoclusters of the present invention is simple and inexpensive; when mixed with commercial phosphors, it can modulate white LEDs and can be used as a light conversion material for environmentally friendly WLEDs.

The invention relates to a supramolecular self-assembly hydrophobic surfactant as well as a preparation method and application thereof, and belongs to the technical fields of supramolecular self-assembly, surface modification engineering and hydrophobic coatings. The surfactant comprises a fluorine-containing compound and absolute ethyl alcohol, and the fluorine-containing compound is self-assembled in the absolute ethyl alcohol to form uniformly dispersed nano small particles; the fluorine-containing compound is obtained by reacting 4-aldehyde imidazole with hexamethylene diisocyanate and then grafting the reaction product on 1H, 1H, 2H, 2H-perfluoro-1-alcohol. Self-assembly in absolute ethyl alcohol is achieved through non-covalent interaction of fluorine-containing compounds, a nano-scale lotus leaf bionic structure is constructed, and the nano-structure material has hydrophobicity and also has a lotus leaf-imitated microcosmic hydrophobic structure and has good hydrophobicity. And when the catalyst is used for Al surface modification, the hydrophobic protection performance of Al can be improved, and a large number of active sites are reserved.

The invention discloses a compound protein stabilizer for a high-internal-phase Pickering emulsion. The compound protein stabilizer is formed by compounding plant protein isolate and animal protein through non-covalent interaction, the plant protein isolate is quinoa protein, the animal protein is whey protein, the particle size of nanoparticles formed after compounding is smaller than or equal to 300 nm, and the Zeta potential is smaller than or equal to-25 mV. The invention provides reliable experimental basis and theoretical basis for further development of edible materials loaded with antioxidant active ingredients in the field of food health.

Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.

The present invention discloses a conductive hydrogel capable of releasing hydrogen sulfide, and a preparation method and application thereof, comprising a hydrogel matrix, a nanocellulose modified conductive nanomaterial, and a hydrogen sulfide donor grafted oxidized polysaccharide, wherein in the hydrogel matrix, polymer molecular chains are entangled to form a three-dimensional network structure, and the nanocellulose modified conductive nanomaterial is uniformly dispersed in the three-dimensional network structure, and establishes strong covalent / or non-covalent interactions with the polymer molecular chains; wherein the mass ratio of the hydrogel matrix, the hydrogen sulfide donor grafted oxidized polysaccharide, and the nanocellulose modified conductive nanomaterial is 1:(0.1-0.5):(0.01-0.02). The present invention improves the strength of the hydrogel by adding the nanocellulose modified conductive material, while ensuring a low loss of elongation at break; and can release hydrogen sulfide gas under the stimulation of cysteine ​​to treat myocardial infarction.

This invention discloses a ternary composite foaming agent of flaxseed protein-fucose-rutin, its preparation method, and its application in meringue cookies. The foaming agent is a non-covalent complex formed by flaxseed protein isolate (FPI), fucoidan (FUC), and rutin (RU) through electrostatic interactions, hydrogen bonds, and hydrophobic interactions, with a mass ratio of FPI:FUC:RU = 1:2:(0.2~0.4). This invention forms a structurally stable composite system through the non-covalent interactions of FPI, FUC, and rutin, achieving a foaming height of 95.69±8.77%. The foam retention rate after 30 minutes is more than double that of natural FPI, and the interfacial tension is reduced to below 25 mN / m, overcoming the shortcomings of poor foaming properties and insufficient stability of single plant proteins. Even after high-temperature baking, the foam retention rate remains above 75%, meeting the processing requirements of meringue cookies.

The present application relates to a kind of PPTA / MWCNT composite fibers and its preparation method, the method first provides two PPTA prepolymer solutions with amine group and acyl chloride group as end group;With any one prepolymer solution as dispersion medium, it is adsorbed on the surface of MWCNT by the non-covalent interaction between prepolymer and MWCNT, realize the in-situ uniform dispersion of MWCNT;Subsequently, another prepolymer solution is added, so that two kinds of prepolymer are in-situ second polymerization on the surface and around MWCNT, obtain PPTA / MWCNT composite solution;The solution is defoamed, filtered and then wet spinning, to obtain composite fiber.The present application realizes the nanoscale uniform dispersion and firm interface combination of MWCNT by the strategy of prepolymer assisted dispersion combined with in-situ polymerization, the polymerization process is mild and stable, the obtained fiber realizes the improvement of thermal conductivity while maintaining high mechanical properties.

The invention discloses a protein ligand binding affinity prediction method based on two-channel hierarchical interactive learning, and particularly relates to an affinity prediction method based on two-channel hierarchical interactive learning. The method comprises the following steps: S1, based on a protein-ligand compound space structure containing a three-dimensional structure and chemical data, constructing six chemical entity interaction diagram networks from an atomic scale to a substructure scale; s2, extracting covalent and non-covalent interaction information of protein-ligands from the internal and external channels at the same time by taking a dual-channel coding framework as a backbone; and S3, adopting a hierarchical interactive learning strategy. According to the affinity prediction method based on the two-channel hierarchical interactive learning, provided by the invention, understanding of protein-ligand complex interaction is enhanced through a technology of modeling richness and complexity of protein-ligand interaction information, so that the protein-ligand binding affinity is comprehensively and accurately predicted.

The invention relates to the technical field of nanogel, and discloses functional polyurea nanogel with universal drug loading capacity as well as a preparation method and application of the functional polyurea nanogel. The invention relates to a functionally modified polyurea compound, which is prepared from the following raw materials: a double primary amine compound, double (2-oxo azacycloheptane-1-formamido alkyl) amine, a polyethylene glycol-amino compound, N, N '-carbonyl double (caprolactam), acid anhydride and an organic solvent. The functionally modified polyurea compound provided by the invention does not contain an isocyanate group and is high in biological safety; the functional polyurea nanogel synthesized by taking a functional modified polyurea compound as a raw material is high in biological safety, has charge overturning performance, has multiple intermolecular non-covalent interaction including hydrogen bond interaction, electrostatic interaction and hydrophobic interaction, can be used for universal drug loading, has pH value responsive swelling property, and can be applied to drug loading. The compound can be used for releasing pH-responsive drugs.

Described are affinity purification system that includes a carrier / surface that is non-cellular, and sliding clamp (SC) protein, and methods for purifying proteins that bind to the SC. The SC is associated with the carrier / surface via covalent / non-covalent interactions. To attain control of coupling site, the SC can be mutated via site-directed mutagenesis to introduce an exogenous residue and, the exogenous internal residue is conjugated to the non-cellular surface through the linker. The SC can also be coupled to the carrier via non-covalent interactions such as the affinity interactions involved in ligand / binding partner complex formation.The SC-based affinity purification system are used in a purification column as bait proteins, to isolate SC binding partners or non SC-binding proteins engineered to contain a SC binding site prior to its purification.

The invention discloses a preparation method of a chiral dendronized diacetylene acid molecule and a supramolecular chiral assembly of the chiral dendronized diacetylene acid molecule, and relates to the field of intelligent chiral materials.The preparation method comprises the steps that firstly, tree-shaped alkoxy ether is combined with PCDA through lysine, the tree-shaped alkoxy ether serves as a hydrophilic element, lysine serves as a chiral source and can provide a large number of hydrogen bonds, the PCDA serves as a hydrophobic element, and the supermolecular chiral assembly of the chiral dendronized diacetylene acid molecule is obtained; chiral dendronized diacetylene acid molecules are designed and synthesized; then, supermolecule chiral assembly is carried out through driving of non-covalent interaction, and supermolecule chiral assembly is regulated and controlled through temperature and light; furthermore, the supramolecular chiral assembly is subjected to optical topological polymerization reaction to prepare the valence-donating chiral polymer. The invention opens up a new way for creating a novel intelligent chiral nano material with a special structure and excellent characteristics.