138 results about "Non-covalent interactions" patented technology

The invention discloses a probiotic-polyphenol nanoparticle colon-targeted co-delivery system as well as a preparation method and application thereof, and belongs to the field of biological medicines. The FCPs and hyaluronic acid (HA) are combined through non-covalent interaction, so that the hydrogel has colon targeting property and mucosal adhesion at the same time, and delivery of probiotics is facilitated. The hydrogel (HF) based on polysaccharide has good biocompatibility, and can be used for effectively encapsulating the probiotics and the natural products. Then, the PDA-TH NPs and BA are incorporated into the polysaccharide chain network of HF, and finally the BA-HF-PDAT targeted co-delivery system is constructed. The BA (at) HF-PDAT targeted co-delivery system can protect BA from serious gastrointestinal stress, and is jointly assembled with PDT-TH NPs to realize dual slow release of thymol (Thy), so that the treatment effect of BA and Thy is improved, and the BA (at) HF-PDAT targeted co-delivery system contributes to treatment of clostridium difficile infection (CDI).

The invention belongs to the technical field of pharmaceutical preparations, and relates to traditional Chinese medicine self-assembled nanoparticles for enhancing anti-inflammatory activity as well as a preparation method and application of the traditional Chinese medicine self-assembled nanoparticles. The traditional Chinese medicine self-assembled nanoparticles are prepared from biphenyl cyclooctene type lignan and an oleanane type pentacyclic triterpenoid compound, wherein the mass ratio of the biphenyl cyclooctene type lignan to the oleanane type pentacyclic triterpenoid compound is 1 to (0.125 to 8). Through an anti-solvent exchange method, the carrier-free nanoparticles based on self-assembly of the traditional Chinese medicine active ingredients are prepared by utilizing spontaneous non-covalent interaction between the biphenyl cyclooctene lignan and the oleanane pentacyclic triterpenoid, so that the cytotoxicity is remarkably reduced, the biocompatibility is enhanced, and the toxic and side effects are reduced; meanwhile, the traditional Chinese medicine self-assembled nano-particles have a remarkable cellular uptake effect, the absorption and utilization efficiency of the medicine is improved, and more efficient anti-inflammatory biological activity is shown.

The invention belongs to the technical field of emulsion materials, and particularly relates to metal-polyphenol network modified coconut protein composite particles as well as a preparation method and application thereof. The preparation method comprises the following steps: preparing a coconut protein-pectin compound by taking coconut protein and pectin as raw materials, adding a tannic acid solution into the coconut protein-pectin compound, mixing, adding a Fe < 3 + > solution, and mixing to obtain metal-polyphenol network modified coconut protein composite particles; according to the preparation method, tannic acid and the coconut protein-pectin compound are subjected to non-covalent interaction, Fe < 3 + > and phenolic hydroxyl groups on the tannic acid are subjected to coordination reaction, a metal-polyphenol network is formed through cross-linking of Fe-O coordination bonds, and a compact modification layer is constructed on the surface of the coconut protein-pectin compound, so that on one hand, waste coconut protein resources are utilized; on the other hand, the problem that composite particles prepared from pectin and coconut protein are prone to depolymerization is solved, the structural stability is improved, and meanwhile iron and polyphenol are supplemented.

The invention discloses a symmetric nucleoside microneedle patch loaded with polymer vesicles as well as a preparation method and application of the symmetric nucleoside microneedle patch. The symmetric nucleoside microneedle patch loaded with the polymer vesicles comprises a guanosine-quadruplex hydrogel microneedle tip doped with drug-loading polymer vesicles, the raw material of the drug-loaded polymer vesicle comprises a polycaprolactone-polyglutamic acid copolymer; the guanosine-quadruplex hydrogel is prepared from the following raw materials: guanosine and KB (OH) 4. The microneedle patch is constructed on the basis of dynamic covalent bond and non-covalent interaction, has a sharp tip array capable of penetrating the epithelium and the lower layer of a mucous membrane, can efficiently deliver a drug to a canker lesion part by bypassing a mucous membrane barrier, can be controllably broken under a high ROS condition of an inflammation microenvironment, has the characteristics of high drug delivery efficiency and high accuracy, and can be used for preparing a medicine for treating the canker lesion part. The effect of effectively improving chemotherapy-induced oral ulceration can be achieved by reducing inflammatory response, relieving pain feeling and inhibiting pain sensitization.

The invention provides a polyurethane urea elastomer, a preparation method and application thereof, and an ionic conductive elastomer, and belongs to the field of polymer materials. A soft-segment substance, isocyanate and a catalyst are subjected to a prepolymerization reaction to obtain a prepolymer, the prepolymer, a chain extender and an organic solvent are subjected to a chain extension reaction to obtain the PUU elastomer, the soft-segment substance contains hydroxyl, and the chain extender contains phenyl and a bishydrazide substituent. According to the invention, PUU is synthesized by a chain extender simultaneously containing phenyl and a bishydrazide substituent, the phenyl in the PUU can be assembled in situ based on pi-pi interaction to form an aggregate, and the aggregate and multiple hydrogen bonds between amido urea bonds on two sides of the aggregate jointly form a double-lock hard domain which has high binding energy and is cross-linked based on non-covalent interaction in the PUU. The unique structure of PUU improves the mechanical properties, including strength, elasticity and tear resistance, of the material on one hand, and endows the material with a function of repairing mechanical damage on the other hand.

Parts made by additive manufacturing are often structural in nature, rather than having functional properties conveyed by a polymer or other component. Printed parts having piezoelectric properties may be formed using compositions comprising a plurality of piezoelectric particles non-covalently interacting with at least a portion of a polymer material via π-π bonding, hydrogen bonding, electrostatic interactions stronger than van der Waals interactions, or any combination thereof. The piezoelectric particles may be dispersed in the polymer material and remain substantially non-agglomerated when combined with the polymer material. The polymer material may comprise at least one thermoplastic polymer, optionally further including a polymer precursor. The compositions may define an extrudable material that is a composite having a form factor such as a composite filament, a composite pellet, a composite powder, or a composite paste. Additive manufacturing processes using the compositions may comprise forming a printed part by depositing the compositions layer-by-layer.

The invention discloses a synthesis method and application of a non-condensed ring electron acceptor, which are different from a traditional condensed ring structure or a single alkyl chain side chain, and a dichlorobenzene unit is introduced as a conformation regulating group. As chlorine atoms have strong electronegativity and proper atomic radius, remarkable non-covalent interaction such as Cl-S and Cl-pi can be generated among molecules. The interaction is similar to a set of precise molecular guide rails, molecules are guided to perform highly ordered pi-pi accumulation, so that electron cloud overlapping is remarkably enhanced, and an efficient electron transmission channel is constructed. According to the organic solar cell prepared based on the non-condensed ring electron acceptor material designed by the invention, the electron mobility is remarkably improved, and meanwhile, the charge recombination loss of a device is effectively reduced.

The invention discloses a drawing rope type supramolecular subject-guest as well as a preparation method and application of the drawing rope type supramolecular subject-guest. The construction unit of the drawing rope type supramolecular subject-object is an assembly constructed by taking a structure as shown in a formula I as a subject macroring and a structure as shown in a formula II as a guest molecule through non-covalent interaction. The drawing rope type supramolecular host-guest is high in thermal stability and can resist high temperature, mechanical properties of a polymer in the aspects of hardness, toughness and strength can be comprehensively improved by adding the drawing rope type supramolecular host-guest into a polymerizable system, and regulation and control of the mechanical properties of the polymer can be achieved by changing the proportion of host macrocycles to guest molecules. Therefore, the functional polymer with various mechanical properties is obtained.

This invention relates to a hyaluronic acid composite hydrogel based on the supramolecular self-assembly of natural molecules and its preparation method, belonging to the field of gel formulation technology. The invention first involves the self-assembly of specific natural molecules or their derivatives possessing hyaluronidase inhibitory and anti-inflammatory activities into stable supramolecular self-assemblies through intermolecular non-covalent interactions. Subsequently, this supramolecular self-assembly is combined with hyaluronic acid through various interactions such as physical entanglement, hydrogen bonding, van der Waals forces, or appropriate chemical cross-linking to construct a composite hydrogel with a uniform internal structure and stable performance. This invention not only achieves long-term, controllable sustained release of natural active ingredients in the gel through supramolecular loading, continuously inhibiting hyaluronidase activity and local inflammatory responses, but also avoids the residual risks associated with high dosages of traditional chemical cross-linking agents, ultimately obtaining a high-quality product that meets the appearance and performance requirements of medical hyaluronic acid gels.

This invention discloses a magnetic covalent organic framework composite material modified with nucleic acid aptamers, its preparation method, and its applications. The composite material uses magnetic iron oxide microspheres as the core, with the surface of the core coated with a shell of covalent organic framework material. Nucleic acid aptamers capable of specifically recognizing tetracycline antibiotics are stably assembled onto the shell surface through non-covalent interactions. This invention fully utilizes the large specific surface area and electron-rich framework of magnetic covalent organic framework materials as efficient carriers for nucleic acid aptamers, effectively overcoming the shortcomings of traditional adsorption materials in terms of poor selectivity and limited adsorption capacity in complex matrices, while avoiding cumbersome covalent modification processes. This composite material exhibits excellent adsorption capacity and superior selectivity for tetracycline antibiotics, and is particularly suitable for rapid and efficient magnetic solid-phase extraction of trace tetracycline antibiotics in complex animal-derived food matrices, significantly improving the detection sensitivity and accuracy of subsequent instrumental analysis.

The invention provides an SPI-CS-EGCG ternary complex as well as a preparation method and application thereof. The preparation method of the ternary complex comprises the following steps: respectively preparing an SPI solution, a CS solution and an EGCG solution; adjusting the pH value of the SPI solution, and heating to obtain SPI microgel; the SPI microgel and a CS solution are mixed and stirred, and an SPI-CS mixed solution is obtained; and mixing and stirring the SPI-CS mixed solution and the EGCG solution, and centrifuging to obtain the SPI-CS-EGCG ternary complex. According to the SPI-CS-EGCG ternary complex, the functional characteristics of SPI are remarkably improved through non-covalent interaction (hydrogen bonds, hydrophobic interaction and Van der Waals' force), and the SPI-CS-EGCG ternary complex has good thermal stability, rheology and tribology characteristics, so that the SPI-CS-EGCG ternary complex has wide application prospects in the food industry.

This invention relates to a mixed solvent-induced highly fluorescent silver nanoclusters, its preparation method, and its application in LEDs. These highly fluorescent silver nanoclusters are formed by the self-assembly of Ag6 in a mixed solvent of water and NMP through non-covalent interactions such as hydrogen bonding and π-π / π* interactions. Due to the restriction of ligand rotation and vibration, the silver nanoclusters exhibit significant fluorescence properties, with fluorescence intensity reaching 10⁻⁶. 7 The fluorescence lifetime is 11.77 μs and the quantum yield is 17.57%. The method for preparing high-fluorescence silver nanoclusters of the present invention is simple and inexpensive; when mixed with commercial phosphors, it can modulate white LEDs and can be used as a light conversion material for environmentally friendly WLEDs.

The invention relates to a supramolecular self-assembly hydrophobic surfactant as well as a preparation method and application thereof, and belongs to the technical fields of supramolecular self-assembly, surface modification engineering and hydrophobic coatings. The surfactant comprises a fluorine-containing compound and absolute ethyl alcohol, and the fluorine-containing compound is self-assembled in the absolute ethyl alcohol to form uniformly dispersed nano small particles; the fluorine-containing compound is obtained by reacting 4-aldehyde imidazole with hexamethylene diisocyanate and then grafting the reaction product on 1H, 1H, 2H, 2H-perfluoro-1-alcohol. Self-assembly in absolute ethyl alcohol is achieved through non-covalent interaction of fluorine-containing compounds, a nano-scale lotus leaf bionic structure is constructed, and the nano-structure material has hydrophobicity and also has a lotus leaf-imitated microcosmic hydrophobic structure and has good hydrophobicity. And when the catalyst is used for Al surface modification, the hydrophobic protection performance of Al can be improved, and a large number of active sites are reserved.

The invention discloses a compound protein stabilizer for a high-internal-phase Pickering emulsion. The compound protein stabilizer is formed by compounding plant protein isolate and animal protein through non-covalent interaction, the plant protein isolate is quinoa protein, the animal protein is whey protein, the particle size of nanoparticles formed after compounding is smaller than or equal to 300 nm, and the Zeta potential is smaller than or equal to-25 mV. The invention provides reliable experimental basis and theoretical basis for further development of edible materials loaded with antioxidant active ingredients in the field of food health.

Drug-loaded microbead compositions include microbeads of a water-swellable polymer material and a complex of a carrier and a therapeutic agent chemically bonded to the carrier. The complex is embedded in the polymer material. Methods for preparing the drug-loaded microbead compositions and embolization compositions include loading a therapeutic agent into a water-swellable polymer material to form microbeads, then removing water from the microbeads. Additional drug-loaded microbead compositions include microbeads of a biodegradable material, vesicular agents, a first therapeutic agent associated with the vesicular agents, and a second therapeutic agent different from the first therapeutic agent. The vesicular agents include a lipid bilayer surrounding a vesicular core. The second therapeutic agent is contained within the microbeads or associated with the microbeads through ionic or non-covalent interaction and may or may not be associated with the vesicular agents. Drug-loaded biodegradable microbead compositions include microbeads of biodegradable material and a therapeutic agent.

This invention discloses a ternary composite foaming agent of flaxseed protein-fucose-rutin, its preparation method, and its application in meringue cookies. The foaming agent is a non-covalent complex formed by flaxseed protein isolate (FPI), fucoidan (FUC), and rutin (RU) through electrostatic interactions, hydrogen bonds, and hydrophobic interactions, with a mass ratio of FPI:FUC:RU = 1:2:(0.2~0.4). This invention forms a structurally stable composite system through the non-covalent interactions of FPI, FUC, and rutin, achieving a foaming height of 95.69±8.77%. The foam retention rate after 30 minutes is more than double that of natural FPI, and the interfacial tension is reduced to below 25 mN / m, overcoming the shortcomings of poor foaming properties and insufficient stability of single plant proteins. Even after high-temperature baking, the foam retention rate remains above 75%, meeting the processing requirements of meringue cookies.

The invention discloses a protein ligand binding affinity prediction method based on two-channel hierarchical interactive learning, and particularly relates to an affinity prediction method based on two-channel hierarchical interactive learning. The method comprises the following steps: S1, based on a protein-ligand compound space structure containing a three-dimensional structure and chemical data, constructing six chemical entity interaction diagram networks from an atomic scale to a substructure scale; s2, extracting covalent and non-covalent interaction information of protein-ligands from the internal and external channels at the same time by taking a dual-channel coding framework as a backbone; and S3, adopting a hierarchical interactive learning strategy. According to the affinity prediction method based on the two-channel hierarchical interactive learning, provided by the invention, understanding of protein-ligand complex interaction is enhanced through a technology of modeling richness and complexity of protein-ligand interaction information, so that the protein-ligand binding affinity is comprehensively and accurately predicted.

Described are affinity purification system that includes a carrier / surface that is non-cellular, and sliding clamp (SC) protein, and methods for purifying proteins that bind to the SC. The SC is associated with the carrier / surface via covalent / non-covalent interactions. To attain control of coupling site, the SC can be mutated via site-directed mutagenesis to introduce an exogenous residue and, the exogenous internal residue is conjugated to the non-cellular surface through the linker. The SC can also be coupled to the carrier via non-covalent interactions such as the affinity interactions involved in ligand / binding partner complex formation.The SC-based affinity purification system are used in a purification column as bait proteins, to isolate SC binding partners or non SC-binding proteins engineered to contain a SC binding site prior to its purification.

The invention discloses a preparation method of a chiral dendronized diacetylene acid molecule and a supramolecular chiral assembly of the chiral dendronized diacetylene acid molecule, and relates to the field of intelligent chiral materials.The preparation method comprises the steps that firstly, tree-shaped alkoxy ether is combined with PCDA through lysine, the tree-shaped alkoxy ether serves as a hydrophilic element, lysine serves as a chiral source and can provide a large number of hydrogen bonds, the PCDA serves as a hydrophobic element, and the supermolecular chiral assembly of the chiral dendronized diacetylene acid molecule is obtained; chiral dendronized diacetylene acid molecules are designed and synthesized; then, supermolecule chiral assembly is carried out through driving of non-covalent interaction, and supermolecule chiral assembly is regulated and controlled through temperature and light; furthermore, the supramolecular chiral assembly is subjected to optical topological polymerization reaction to prepare the valence-donating chiral polymer. The invention opens up a new way for creating a novel intelligent chiral nano material with a special structure and excellent characteristics.

The invention belongs to the technical field of environmental restoration, and particularly relates to cyclodextrin cross-linked supramolecular hydrogel as well as a preparation method and application thereof. A construction unit of the supramolecular hydrogel comprises double-bond modified beta-cyclodextrin and acrylic acid interacting with the double-bond modified beta-cyclodextrin through a covalent bond; plant hormones are included in a cavity of the double-bond modified beta-cyclodextrin. The supramolecular hydrogel adhesive tape is provided with charges and cavities, can include plant hormones, and can be used together with soil improvement plants such as green manure to enhance the saline-alkali soil improvement effect by regulating and controlling the salinity of plant rhizosphere soil, improving the emergence rate, promoting plant growth and improving the environmental stress resistance of the plants. Cavities of the double-bond modified beta-cyclodextrin can effectively include plant hormones, and the supramolecular hydrogel is formed through covalent interaction between the acrylic acid and the double-bond modified beta-cyclodextrin. Based on multi-covalent and non-covalent interaction, the supramolecular hydrogel has the advantage of controllably releasing plant hormones, and realizes sustainable environmental remediation by cooperating with plant remediation.

The application belongs to the technical field of water body remediation, and particularly relates to a method for removing heavy metals in water bodies by using supramolecular hydrogel. The supramolecular hydrogel used in the application is amino clay and carboxymethyl beta-cyclodextrin supramolecular hydrogel. The supramolecular hydrogel used in the application has charges and a porous structure, can produce adsorption on heavy metal ions, and can remove heavy metal ions in water bodies, has high environmental remediation efficiency, has a short remediation period, and has a water body heavy metal ion removal rate of more than 99% at 14 days. The supramolecular hydrogel used in the application has high-performance capture of chemical pollutants based on the porous structure and orthogonal non-covalent interaction-electrostatic interaction, and can be an efficient platform for sustainable water body environmental remediation.

Disclosed herein is a modified oligonucleotide, the modified oligonucleotide comprises one or more modifications in at least one of a phosphate backbone, a nucleobase, or a sugar. The one or more modifications impede translocation through a nanopore by increasing non-covalent interactions with the interior of the nanopore or the lipid bilayer that supports the nanopore, increasing the bulk size or the steric hinderance of oligonucleotide, or alter the charge density of the oligonucleotide.

The invention discloses a cucurbit [5] uril-based framework material as well as a preparation method and application thereof, and belongs to the crossing field of supramolecular chemistry and functional materials. The preparation method comprises the following steps: dissolving potassium salt and cucurbit [5] uril in distilled water; then adding a 3, 3 '-disulfo-[1, 1'-biphenyl]-4, 4 '-dicarboxylic acid ligand, and stirring to obtain a mixed solution; the mixed solution is subjected to a heating reaction, then cooling, filtering and drying are conducted, and the cucurbit [5] uril-based framework material is obtained, and the chemical formula is C396H360K18N180O198S18. Through coordination of an organic ligand containing a sulfonic acid group and metal ions, in combination with non-covalent interaction of hydrogen bonds, Van der Waals force and the like, and through optimal regulation and control of a material ratio, pH and temperature, a honeycomb three-dimensional porous framework structure with high stability is successfully constructed. By utilizing the fluorescence characteristic and the structural characteristic, the efficient recognition of Fe < 3 + > and Pb < 2 + > heavy metal ions and norfloxacin antibiotics in a water body can be realized. The problems that in the prior art, when heavy metal ions and antibiotics in water are detected, operation is tedious, and cost is high are solved.

The application provides a platelet-responsive self-gelation hemostatic material and a preparation method and application thereof, and belongs to the medical field. Based on a multiple cross-linking strategy of dynamic covalent bonds and non-covalent interactions, a hemostatic material capable of realizing self-gelation quickly is designed by using modified sodium alginate and hydroxylated porcine small intestinal submucosa as raw materials. The hemostatic material has good hydrophilicity and liquid absorption capacity, can realize powder-gelation transformation in a short time, form a stable physical barrier, has platelet response characteristics, can promote platelet adhesion and activation, accelerate the blood coagulation process of the body, and improve the mechanical properties and tissue adhesion of the material, and has a good application prospect.

This invention discloses a method and system for training and identifying non-covalent interaction models. The identification method includes: acquiring the spatial structure information of the molecular structure to be identified; inputting the spatial structure information of the molecular structure to be identified into an identification model based on a preset electron density; and generating the position coordinates and topological features of non-covalent interactions in the molecular structure to be identified through the identification model. The technical solution provided by this invention solves the problem of inaccurate identification of non-covalent interactions in molecular systems.

The invention discloses a conductive graphene yarn and a preparation method and application thereof, and belongs to the technical field of conductive fibers. The conductive graphene yarn prepared by the method is obtained by blending and spinning high-dispersion graphene oxide A, polyacrylonitrile and polyvinylpyrrolidone, soaking the mixture in a hydroxylamine hydrochloride solution for the first time, soaking the mixture in high-dispersion graphene oxide B for the second time, and finally soaking the mixture in the hydroxylamine hydrochloride solution for the third time. The high-dispersion graphene oxide A is obtained by adsorbing aromatic amino acid on the surface of graphene oxide through non-covalent interaction such as pi-pi; the high-dispersion graphene oxide B is obtained by adsorbing cinnamyl aldehyde on the surface of graphene oxide through non-covalent interaction such as pi-pi; the prepared conductive graphene yarn is good in conductivity, higher in tensile strength and good in antibacterial property.

This invention provides a bio-based binder composition and preparation method therefor. In one embodiment, said bio-based binder composition comprises: a) 0.01 to 60 wt.% of a polyphenol; b) 0.5 to 90 wt.% of a first bio-based polymer, comprising multiple amino or hydroxyl groups as first Michael donors for a first Michael addition reaction with a first Michael acceptor formed by oxidation of said polyphenol; c) 0.5 to 90 wt.% of a second bio-based polymer; d) 0.01 to 50 wt.% of a metallic compound, said metallic compound is selected from the group consisting of aluminum(III), calcium(II), copper(II), gold(III), silver(I), titanium(IV), sodium (I) and zinc(II) compounds; and e) 1 to 99 wt.% of a protic solvent; wherein said bio-based binder composition can be adjusted to a condition for forming a transparent polymeric network cross-linked by covalent and non-covalent interactions.

The invention discloses a TEAD inhibitor, which comprises a compound as shown in a general formula (I) or a general formula (II), and a stereoisomer or a salt thereof: the two compounds break through the limitation that the existing inhibitor only depends on a single non-covalent interaction through a hydrophobic effect, a hydrophilic effect and a multi-dimensional mechanism of covalent binding; the invention provides two brand new skeletons of carboxylic acid and acrylamide, enriches the structural types of the TEAD inhibitor, realizes more efficient and more specific inhibition of TEAD transcriptional activity through accurate design of different regions of a palmitoylated pocket, provides a candidate compound library with various structures for developing high-activity and high-selectivity antitumor drugs, and has a wide application prospect. The problems of insufficient activity, low selectivity and single structure of inhibitors in the prior art are effectively solved.

The invention belongs to the technical field of adhesives, and particularly relates to an adhesive as well as a preparation method, application and a use method thereof. According to the method, bamboo wood is disintegrated to obtain an extract with lignin as a main component, and the extract and cellulose are assembled through non-covalent interaction to construct the adhesive; the obtained adhesive is adhered to a base material in a high-temperature hot pressing manner, so that the use of toxic reagents such as formaldehyde is avoided while high-strength adhesion is realized. The adhesive obtained by the invention can stably bond wood and various substrates, is waterproof, formaldehyde-free, green and environment-friendly, and the preparation method is simple and does not need precious precise instruments.

This invention relates to the field of medical materials technology, providing a hydrogel containing antler mesenchymal stem cell exosomes, its preparation method, and applications. The method includes the following steps: preparation of antler mesenchymal stem cell exosomes; preparation of PVP-HA composite hydrogel; uniformly mixing AMSC-Exos with a hydrogel precursor solution, and forming a hydrogel containing antler mesenchymal stem cell exosomes through physical embedding and non-covalent interactions. This invention utilizes the three-dimensional porous network structure of the hydrogel to achieve long-term sustained release of exosomes, protecting them from rapid degradation; it leverages the unique regenerative advantages of antler-derived exosomes to synergistically promote angiogenesis, inhibit inflammatory responses, and regulate macrophage polarization; it promotes angiogenesis through the miR-486-5p / FGF9 axis, achieving efficient repair of chronic diabetic wounds; and it provides a novel, efficient, safe, and clinically translational strategy for the treatment of chronic diabetic skin lesions.