17 results about "Carrier solution" patented technology

A method for immobilizing beta-glucanase based on a rice husk-sodium alginate composite carrier belongs to the field of enzyme engineering and biological materials, and comprises the following steps: 1) crushing and sieving rice husks; 2) mixing rice husks and sodium alginate according to a mass ratio of 1: 3-1: 6, and performing ultrasonic dispersion and magnetic stirring to form a carrier solution; (3) adding beta-glucanase into the carrier solution, and reacting for 35-50 minutes at the temperature of 30-35 DEG C; and 4) dropwise adding the enzyme-carrier mixed solution into a calcium chloride solution for curing and forming, and washing and drying to obtain the immobilized enzyme particles. By optimizing the ratio of the composite carrier, when the mass ratio of the rice husks to the sodium alginate is 1: 4, the catalytic activity of the prepared immobilized enzyme under unit mass is obviously higher than that of other ratio groups. According to the method, agricultural waste rice hulls are used as main raw materials, the cost is low, the process is simple, the prepared immobilized enzyme is high in activity, and a new way is provided for industrial application of beta-glucanase.

The invention discloses a tellurium-based nano material capable of efficiently inducing copper death as well as a preparation method and application of the tellurium-based nano material. The preparation method comprises the following steps: by taking water as a medium, mixing soluble copper salt and a sulfydryl-containing compound, and stirring to react, so as to obtain a Cu-S2 solution; dropwise adding the Cu-S2 solution into the TeO2 nano-carrier solution, and carrying out stirring reaction; and after the reaction is finished, carrying out solid-liquid separation, taking the solid, and resuspending with methanol to obtain the TeO2 coated Cu-S2 nano material. The preparation method is simple and rapid, large-scale production can be achieved, and the obtained TeO2 coated Cu-S2 nano material can efficiently induce cancer cells to generate copper death, is effective to various cancer cells and has potential clinical transformation application prospects.

A fixing carrier unit for selective wave soldering and a fixing carrier assembled therefrom are disclosed, belonging to the technical field of soldering carriers in the electronics manufacturing industry. The unit includes a wave soldering substrate, an FPCA device mounted on the substrate, a connector inserted into the FPCA device, and a pressure block covering the FPCA device and connector. The pressure block includes a working surface in contact with the FPCA device and connector, and an upper surface opposite to the working surface. A cavity is formed on the working surface, the cavity having a through portion and a sealing portion. The through portion accommodates the protrusion of the connector, and a resilient pin is disposed on the pressure block of the sealing portion. This provides a novel selective wave soldering fixing carrier solution that uses the pressure block to limit the misalignment of the pins and FPC pads.

The application discloses a sea fennel composite intelligent microcapsule based on sequential cross-linking, a preparation method and application, and belongs to the technical field of biomedicine.The application provides the sea fennel composite intelligent microcapsule based on sequential cross-linking, aiming at the problems of chemical instability, low transdermal rate, lack of environmental responsiveness of sea fennel extract, and loose capsule wall structure of existing microencapsulation technology, and incapability of precise control.Through integration of high-controllable technologies such as microfluidic layer-by-layer self-assembly, isothermal titration calorimetry monitoring cross-linking and atomic force microscope-nano indentation characterization, three-step sequential cross-linking is adopted to construct the intelligent microcapsule which is uniform in structure, excellent in mechanical performance, has a precise pH response threshold, realizes mild and efficient encapsulation of active substances, actively senses the skin barrier state and precisely controls the release, and synergistically enhances the mechanical strength and processing resistance, thereby providing a carrier solution with high technical barriers for high-end functional cosmetics.

The present invention provides an adjustment device for adjusting the distance between two components that is easy to operate, has a simple structure, and can be used reliably, as well as a carrier having the adjustment device. [Solution] An adjustment device comprising: a locking member having a locked position and an unlocked position; a fixed end; an operating end; and an adjustment member having at least two sliding contact portions and at least one locking portion located between the fixed end and the operating end, wherein the sliding contact portions and locking portions are alternately arranged, the sliding contact portions and the locking member are slidably engaged, thereby allowing the locking member to slide against the adjustment member at the sliding contact portions; when the locking member is in the locked position, the locking portions prevent the locking member from sliding against the adjustment member from one side away from the operating end of the locking portion toward the operating end; when the locking member is in the unlocked position, the locking member can slide against the adjustment member from one side away from the operating end of the locking portion toward the operating end.

Provided is a method to prepare a solid dispersion composition comprising an active pharmaceutical ingredient (API) and a pharmaceutically acceptable dispersion carrier, which includes (a) dissolving the API and the pharmaceutically acceptable dispersion carrier in a solvent to form a dissolved API / pharmaceutically acceptable dispersion carrier solution; and / or (b) combining the dissolved API / pharmaceutically acceptable dispersion carrier solution and an anti-solvent to form a combination, wherein the anti-solvent comprises a surfactant; and / or (c) mixing the combination to generate an emulsion with a predetermined mean particle size range; and / or (d) removing the solvent from the emulsion to generate the solid dispersion composition, wherein the solid dispersion composition has the predetermined mean particle size range. Preferably, the API in the solid dispersion composition is amorphous. Also provided is an emulsion and / or a solid dispersion composition comprising the API and a dispersion carrier. Also provided is a solid dispersion made by the methods of the invention. In embodiments, the present invention includes Compound (1), also known as zongertinib, and apparatus for continuous processing according to the methods disclosed herein.

This invention belongs to the field of pharmaceutical technology, specifically relating to a method for preparing mabaloxavir tablets and its application. This invention uses lactose dodecyl ester and microcrystalline cellulose to microcrystallize mabaloxavir, reducing its particle size and increasing its specific surface area, thereby accelerating the drug's dissolution rate in vivo, improving its bioavailability, allowing the drug to exert its effects more quickly, and shortening the patient's treatment cycle. The use of lactose dodecyl ester, microcrystalline cellulose, croscarmellose sodium, and povidone K25 as excipients helps form a uniform and stable carrier solution and mixture, and also improves the tablet's formability, disintegration, and dissolution properties during tableting, improving tablet quality and stability, reducing gastrointestinal irritation, and enhancing patient medication adherence.

The invention discloses a preparation method of a platinum-based catalyst for catalytic degradation of short-chain hydrocarbon VOCs (Volatile Organic Compounds), which comprises the following steps: dissolving a cobalt salt precursor and a zirconium salt precursor in a molar ratio of (8-9): 1 in ultrapure water, adding an organic acid solution while stirring, and ensuring that the molar concentration of the organic acid solution is higher than that of a total metal salt solution; stopping stirring after the solution generates a gelatinous substance, raising the temperature to 70-100 DEG C, and drying overnight; grinding the obtained solid material, and roasting in a muffle furnace; after cooling, weighing a certain mass of product, dissolving in a proper amount of ultrapure water, and stirring to obtain a carrier solution; and dropwise adding an active noble metal platinum precursor salt solution into the carrier solution, fully stirring, drying overnight, roasting a sample in the air at 300-400 DEG C for 3-5 hours, cooling, and introducing a mixed gas of hydrogen and nitrogen for reduction. The catalyst prepared by the method is simple in preparation method, has excellent sulfur tolerance, and can catalytically decompose ethane at the temperature of lower than 300 DEG C.

Provided is a method to prepare a solid dispersion composition comprising an active pharmaceutical ingredient (API) and a pharmaceutically acceptable dispersion carrier, which includes (a) dissolving the API and the pharmaceutically acceptable dispersion carrier in a solvent to form a dissolved API / pharmaceutically acceptable dispersion carrier solution; and / or (b) combining the dissolved API / pharmaceutically acceptable dispersion carrier solution and an anti-solvent to form a combination, wherein the anti-solvent comprises a surfactant; and / or (c) mixing the combination to generate an emulsion with a predetermined mean particle size range; and / or (d) removing the solvent from the emulsion to generate the solid dispersion composition, wherein the solid dispersion composition has the predetermined mean particle size range. Preferably, the API in the solid dispersion composition is amorphous. Also provided is an emulsion and / or a solid dispersion composition comprising the API and a dispersion carrier. Also provided is a solid dispersion made by the methods of the invention. In embodiments, the present invention includes Compound (1), also known as zongertinib, and apparatus for continuous processing according to the methods disclosed herein.

The embodiments of the present application relate to the technical field of coating. Disclosed are a coating composition, a coating method for accentuating wood grain, and a coated wood. The coating composition and coating method provided in the present invention provide an effective solution to the problems in the prior art of the presentation of wood grain being unclear, and the coating having an excessively high hiding power and being prone to discoloration. Shellac or a shellac-based derivative material is selected as a film-forming agent, and is formulated with a suitable volatile carrier solution, thereby ensuring that a paint film formed by a coating on a wood surface is transparent and long-lasting, and prolonging the service life of the wood surface. By means of the detailed coating steps, it is ensured that the coating uniformly covers the wood surface and penetrates deep into fine pores of the wood, such that wood grain is more distinct, and wood grain blurring caused by coating accumulation or uneven coating penetration in conventional processes is prevented. In summary, the coating composition and coating method of the present invention achieve an ideal effect of both aesthetics and practicality.

The invention relates to the technical field of biological medicine, in particular to a method for improving the bioavailability of curcumin and a preparation. According to the preparation method, a curcumin solution / carrier solution is prepared under the alkaline condition, the composition of the wall material is optimized, an alkaline core material-composite wall material-homogeneous stabilization-spray drying integrated micro-capsule preparation process is formed, and efficient embedding and stable delivery of curcumin can be achieved; the preparation process is simple, low in energy consumption, low in production cost and suitable for large-scale production and application; the curcumin microcapsule provided by the invention takes a'protein-cyclodextrin-curcumin 'ternary complex as an inner core, takes maltodextrin as a shell layer, is nanoparticles with uniform particle size, has a high Zeta potential absolute value, an embedding rate up to 97-99% and a drug loading rate up to 9-15%, greatly improves the water solubility, palatability, storage stability and bioavailability of curcumin, and is suitable for industrial production. And the application range of curcumin in oral preparations is widened.

The invention discloses a bifidobacterium animalis subsp. Lactis BD108 preparation as well as application and a product of the bifidobacterium animalis subsp. Lactis BD108 preparation in emotion regulation, and belongs to the technical field of microorganisms. The invention aims to solve the technical problems that the survival rate of viable bacteria is low after oral administration, the mood improvement effect is unstable and long-acting intervention is difficult to realize due to the problems of weak strain specificity, insufficient mood regulation activity, poor preparation protection effect, single action pathway and the like existing in the conventional probiotic strain in mood regulation application. According to the key point of the technical scheme, the freeze-dried microsphere preparation of the animal bifidobacterium subsp. Lactis BD108 is provided and comprises the animal bifidobacterium subsp. Lactis BD108 and a composite carrier solution, the preservation number of the animal bifidobacterium subsp. Lactis BD108 is GDMCC (China General Microbiological Culture Collection Center) No.67826; the composite carrier solution is composed of trehalose, pullulan, whey protein phosphopeptides and a solvent.

The invention relates to a pH response type composite microneedle and a preparation method thereof, and belongs to the technical field of medical materials. The preparation method comprises the following steps: S1, dropwise adding a drug solution into a carrier solution, dropwise adding a cross-linking agent solution, uniformly stirring, centrifuging and resuspending to obtain a pH-responsive drug-loaded nanoparticle suspension; the carrier solution is prepared by dissolving a pH-responsive carrier in a first solvent; the cross-linking agent solution is prepared by dissolving a cross-linking agent in water; the electrical properties of the pH response type carrier and the cross-linking agent are opposite; s2, the pH response type drug-loaded nanoparticle suspension and the silk fibroin solution are stirred and ultrasonically defoamed and then are filled into a PDMS mold, a microneedle array is obtained through centrifugation, drying and steam annealing treatment and stripping in sequence, then the bottom face of the microneedle array is attached to a medical breathable adhesive tape, and the pH response type composite microneedle is obtained. Through cooperation of materials, structures and processes, intelligent targeting and efficient treatment are realized.

The application discloses a kind of solid dispersion nanoparticles and preparation method thereof, belong to medical technology field, using SAS process to obtain drug-carrier solution to further prepare telmisartan binary solid dispersion and telmisartan ternary solid dispersion.The application uses the above-mentioned one kind of solid dispersion nanoparticles and preparation method thereof, using SAS method successfully prepares telmisartan binary solid dispersion, ternary solid dispersion;And the construction of SAS method to telmisartan solid dispersion system, breaks through the limitation of traditional method, can accurately control particle size, stable formation amorphous drug to improve dissolution, can also protect the activity of heat-sensitive component and realize low solvent residue, with process flexibility and industrialization potential.

The invention discloses a preparation method of a lignin-based room-temperature phosphorescent composite film and application of the lignin-based room-temperature phosphorescent composite film in anti-counterfeiting encryption, and belongs to the technical field of catalytic conversion of lignin into room-temperature phosphorescent materials. The preparation method comprises the following steps: dissolving a carrier material in deionized water to prepare an aqueous carrier solution, and dissolving carbazole-benzophenone lignin-based phosphorescent molecules in an organic solvent to prepare a phosphorescent molecule mother solution; and uniformly mixing the aqueous carrier solution and the phosphorescent molecule mother liquor by ultrasonic treatment, transferring into a mold, and drying in a drying oven to form a film, thereby obtaining the lignin-based room-temperature phosphorescent composite film. The prepared composite film shows controllable changes of phosphorescence afterglow duration and color in the water absorption / water removal process, pattern encryption, digital secondary encryption and intelligent anti-counterfeiting of products such as medicine bottles can be achieved, the preparation process is green, simple and convenient, raw materials are renewable, the green chemistry concept is met, and the composite film has wide application prospects in the field of intelligent anti-counterfeiting encryption.

This invention discloses a silver-coated nickel paste for thermistors and its preparation method, relating to the field of conductive materials of metals or alloys. The raw materials, by weight percentage, include 5-10% carrier solution, 30-50% silver powder, 3-5% glass powder, 10-20% silver-coated nickel powder, and 2-30% organic solvent, with a total weight percentage of 100%. The silver content in the silver-coated nickel powder is 10-30 wt%. This invention uses silver-coated nickel powder to replace part of the silver powder, providing excellent thermal stability, effectively suppressing thermal expansion mismatch at high temperatures, making it suitable for thermistors, and reducing the cost of precious metals. Using silver-coated nickel powder with a silver content of 10-30 wt% can maintain stable welding pull force, and exhibit low surge impact resistance change rate and steady-state current resistance change rate.

The invention provides multifunctional polystyrene microspheres as well as a preparation method and application thereof, and belongs to the technical field of polymer functional materials. The preparation method comprises the following steps: (1) adding a carbon dot solution into a solution containing a polystyrene microsphere carrier, and encapsulating carbon dots into the polystyrene microsphere carrier; and (2) adding a polyethyleneimine solution and a gold nano solution into the polystyrene fluorescent microsphere carrier solution obtained in the step (1) to obtain the multifunctional polystyrene microsphere material. According to the invention, the carbon dots are encapsulated into the polystyrene microsphere carrier by using a swelling method, so that the problem that the fluorescence function of the non-water-soluble carbon dots in a hydrophilic environment is weakened is solved; meanwhile, the gold nanoparticles are directionally anchored on the surfaces of the polystyrene microspheres through electrostatic self-assembly, so that the microspheres are endowed with additional colorimetric and peroxidase-like catalytic activity, three-signal output of fluorescence, colorimetric and catalysis is realized, the false positive rate is remarkably reduced, and the detection accuracy is improved.