42 results about "Transdermal penetration" patented technology

The object of this invention is a lipophilic activity modifier in the form of dimethyl sulfone (MSM) for use as a transdermal penetration enhancer for high molecular weight active substances with a molecular weight (Mw) > 500 Da. Another object of this invention is a cosmetic composition for transdermal application comprising an active substance and a transdermal penetration enhancer, characterized in that the active substance is encapsulated by the transdermal penetration enhancer, which is the lipophilic activity modifier according to claim 1, and the active substance is a high molecular weight active substance with a molecular weight (Mw) > 500 Da. Another object of the present invention is a method for preparing a composition according to the invention, characterized in that the method is carried out by thermal emulsification or cold emulsification, wherein thermal emulsification comprises the following steps: a) mixing dimethyl sulfone and a diluent in a reaction vessel; b) bringing the mixture to 70-85°C; c) stirring the mixture at 70-85°C; the start of homogenization depends on the stage of phase combination; d) cooling the mixture to 20-40°C, preferably 30°C; e) adding a high molecular weight active substance with Mw>500 Da and homogenizing the mixture, preferably for 1-3 min; while cold emulsification comprises the following steps: a) mixing dimethyl sulfone and a diluent in a reaction vessel and dissolving at a temperature maintained at 20-25°C; b) bringing the mixture to a temperature of 15-35°C, preferably ambient temperature or 25°C; c) stirring the mixture at a temperature of 15-80°C, preferably 25°C; the start of homogenization depends on the stage of phase combination; d) adding a high molecular weight active substance with Mw>500 Da and homogenizing the mixture, preferably for 1-3 min.

The invention relates to a multi-target anti-aging transdermal penetration enhancing composition based on synergistic interaction of PDRN and natural fermentation and application of the multi-target anti-aging transdermal penetration enhancing composition. The composition comprises saccharomycetes / rice fermentation product filtrate, kelp extract and PDRN in a mass ratio of (0.1-20): (0.05-4): (0.01-3), and is prepared according to the following steps: adding a solvent and a humectant into a container, and continuously stirring until the solvent and the humectant are completely dissolved; adding a chelating agent and a skin conditioner, and performing heat-preservation stirring until a system is uniform and transparent; adding the emulsifier, preserving heat and stirring until the emulsifier is completely dissolved; stopping heating, cooling, adding the functional components and the preservative, and stirring until the components are uniformly mixed; and quantitatively filling in a sterile environment. Compared with the prior art, the hydration environment of the yeast / rice fermentation product filtrate improves the transdermal efficiency of the kelp extract and PDRN; the kelp extract eliminates ROS, resists saccharification and reduces oxidative damage; the deep repair function of the PDRN reversely enhances the epidermis repair effect of the PDRN and the PDRN, and a synergistic effect of '1 + 1 + 1gt; 3' is formed.

The invention belongs to the field of transdermal drug delivery materials, and provides a high-molecular sustained-release material for sleep disorders and a preparation method of the high-molecular sustained-release material. The design that a star-shaped polyurethane-silane prepolymer is self-assembled in an ethanol-water mixed solvent to form nano-micelles, melatonin is loaded, and a Si-O-Si cross-linked stable structure is formed on a shell layer through hydrolytic condensation of triethoxysilane is adopted, the median particle size of the obtained nano-dispersion system is 80-200 nanometers, the drug loading capacity is 5-20%, and the stability of the melatonin is improved. And propylene glycol is used as a penetration enhancer to form a coating transdermal drug delivery preparation. The synergistic improvement of low viscosity, coating processability, shell crosslinking stability, drug sustained release and transdermal permeability under high solid content is realized. The problem that an existing nano-micelle film-forming type percutaneous dispersion system is difficult to give consideration to coupling contradictions of a processing window, drug release permeability and safety is solved, and the nano-micelle film-forming type percutaneous dispersion system has wide application value in the field of sleep disorder percutaneous treatment.

The application discloses a quick and efficient melatonin transdermal delivery system, which is characterized by comprising the following structures arranged from top to bottom: at least one protective layer; at least one polymer base layer; and a multilayer structure of an anti-adhesion layer; wherein the polymer base layer comprises the following components by weight: compared with the prior art, the system has the following beneficial effects: compared with oral use of melatonin, the melatonin efficient delivery system reduces the dosage of melatonin by 50% to 400% and reduces side effects, and can improve the transdermal penetration rate of melatonin within the first two hours.

The application discloses a sustained-release transdermal patch and a preparation process thereof, and particularly relates to the technical field of pharmaceutical preparations. The patch is a five-layer composite structure, and the key lies in that: the adhesive layer and the drug depot layer both contain ion pairs of clonidine and organic acid formed in situ under specific solvent and temperature conditions, and the formation of the ion pairs is confirmed by pH value or infrared spectrum; and specific transdermal penetration enhancers are further compounded, so that programmed controlled release is realized through the cooperation of the two layers. The preparation process adopts the sequence of forming ion pairs first and then mixing, realizes coating precision of ±2μm through slit extrusion coating combined with online thickness measurement closed-loop control, adopts gradient drying process with clear temperature zone, air speed and humidity parameters, and carries out real-time quality control based on the online near-infrared spectrum detection of the pre-established PLS regression model. The process can ensure that the patch realizes near-zero-order constant-speed release within 168h, and has the advantages of stable drug release, uniform content, stable quality and high batch consistency.

The application discloses a traditional Chinese medicine plaster for lumbar disc herniation and a preparation method thereof, and relates to the technical field of biological medicine. In the microneedle layer, macromolecular antler active components are loaded, and a liposome transition depot layer and an enzyme-responsive hydrogel controlled-release layer are constructed on the surface of the microneedle layer. Through the system integration of the three-layer structure, a complete treatment chain of puncture, transdermal penetration, transition depot, intelligent response and controlled release is constructed. The microneedle layer breaks through the physical barrier of the stratum corneum, directly delivers the antler active components and analgesic anti-inflammatory components to the dermis layer, and realizes rapid effect. The liposome transition depot layer provides secondary release and protection, maintains the drug concentration platform, and realizes continuous supply. The enzyme-responsive hydrogel controlled-release layer intelligently adjusts the drug release rate according to the pathological state of the lesion, and realizes on-demand drug release. The antler active components promote the repair of nucleus pulposus cells and nerve regeneration, and the CeO2@PDA nanoenzyme removes ROS to improve the microenvironment, realizing the treatment of both the symptoms and the root cause.

A catgut implant for treating ascites and a preparation method thereof belong to the technical field of catgut preparation. Raw materials are as follows in percentage by mass: 27-31% of Gansui Banxia extract, 25-28% of humectant, 27-31% of water, 0.5-0.8% of glycyrrhizic acid, 5-9% of polyacrylic acid sodium, 1.5-4% of carboxymethyl cellulose sodium, 0.9-2.5% of polyvinylpyrrolidone, 0.03-0.06% of disodium edetate, 0.2-1.3% of organic acid, 0.5-0.9% of filling agent and 0.2-2% of transdermal penetration enhancer. The catgut implant improves the production process of catgut, reduces the production cost of catgut, has good formability and adhesion, and prepares Gansui Banxia decoction for treating ascites into catgut implant with controllable quality.

The invention provides a transdermal promotion type traditional Chinese medicine sustained-release plaster and a preparation method thereof, the transdermal promotion type traditional Chinese medicine sustained-release plaster comprises a backing layer and an ointment-containing body coated on the surface of the backing layer, and the surface of the ointment-containing body is covered with a release layer; the ointment-containing body comprises a traditional Chinese medicine extract, a hydrogel matrix, a slow release agent and a composite transdermal enhancer; the hydrogel matrix comprises isopropyl acrylamide, acrylamide, a metal organic framework material, cellulose nanofibers, an initiator, a cross-linking agent, a humectant, a binder, a skin feeling regulator and deionized water; the composite transdermal enhancer comprises menthol, azone, propylene glycol and oleic acid. According to the invention, the drug sustained-release effect is realized by utilizing the temperature-sensitive characteristic of the hydrogel matrix and combining with the sustained-release agent, and the percutaneous penetration effect on the complex-component traditional Chinese medicine extract is improved by compounding a plurality of transdermal promoters; the patch has the advantages of moisture retention, breathability, repeated uncovering and pasting, low skin irritation and allergy risk, long drug effect exertion time, few drug use times, good treatment effect and the like.

The invention discloses a macrolide and isoxazoline medicine combined local external preparation for dogs as well as a preparation method and application thereof, belongs to the technical field of veterinary medicines, and solves the problems that an existing preparation is limited in solvent selection, lacks a long-acting slow-release mechanism, is relatively high in medicine release speed, cannot maintain an effective concentration on the body surface of a dog for a long time, and cannot be used for a long time. The local external preparation is prepared from the following raw materials: a preparation main material, an auxiliary solvent, a synergist, a transdermal penetration enhancer, an antioxidant and a surface film-forming agent, according to the macrolide and isoxazoline medicine combined local external preparation for dogs, the solvent, the synergist and the transdermal penetration enhancer with good solubility are selected for combined use in preparation of the preparation, so that the medicine can be effectively dissolved, the permeability of the medicine in the skin of dogs is improved, the purpose of long-acting medicine release is achieved, and the curative effect of the dogs is improved. The bioavailability of the medicine is improved.

The invention discloses a ceramide transdermal enhanced transporter preparation as well as a method and application thereof, and belongs to the technical field of transdermal delivery preparations. The preparation comprises the following components in parts by mass: 5-15 parts of hydrogenated lecithin, 1-5 parts of ceramide, 2-8 parts of cholesterol, 1-3 parts of stearic acid, 0.5-5 parts of an edge activator, 20-50 parts of absolute ethyl alcohol and 100-200 parts of ultrapure water, and the edge activator is selected from one of sodium cholate, SP60 or sucrose stearate and has a specific concentration gradient. The preparation method comprises the steps of organic phase preparation, water phase pretreatment, mixed hydration and particle size adjustment. The edge activator is used for regulating and controlling a lipid bilayer structure, the deformation index of the preparation is remarkably increased, the problems that ceramide is poor in water solubility, prone to crystallization and low in transdermal efficiency are solved, the preparation is excellent in stability, the intradermal retention amount and the skin permeation amount are remarkably higher than those of traditional lipidosome, deep skin delivery of ceramide can be achieved, and the application prospect is wide. And the composition has no skin irritation and is suitable for preparing skin barrier repairing, moisturizing or anti-inflammatory external products.

The invention discloses a sustained and controlled release transdermal patch and a preparation process thereof, and particularly relates to the technical field of pharmaceutical preparations, the patch is of a five-layer composite structure, and the patch is characterized in that an adhesive layer and a drug storage layer both contain ion pairs formed by clonidine and organic acid in situ under specific solvent and temperature conditions; the formation of the composition is confirmed through a pH value or an infrared spectrum, then a specific percutaneous penetration enhancer is compounded, and programmed controlled release is realized through double-layer synergy. The preparation process adopts a sequence of firstly forming ion pairs and then mixing, the coating precision of + / -2 microns is realized by matching slit extrusion coating with on-line thickness measurement closed-loop control, and real-time quality control is performed by adopting a gradient drying process with clear temperature zone, wind speed and humidity parameters and on-line near infrared spectrum detection based on a pre-established PLS regression model. The process disclosed by the invention can ensure that the patch realizes near-zero-level constant-speed release within 168 hours, and has the advantages of stable drug release, uniform content, stable quality and high inter-batch consistency.

The invention discloses a preparation method of eutecticevaporate gel for promoting transdermal delivery of drugs, the eutecticevaporate gel is prepared by heating an alcohol substance, a chitosan derivative and choline chloride according to a specific mass ratio, and the prepared gel can simultaneously encapsulate a water-soluble drug and a fat-soluble drug with high loading capacity to form a composite preparation. The eutecticevaporate gel prepared by the invention has excellent drug solubility and percutaneous penetration promotion effect of the eutecticevaporate solvent and good adhesion and controllable release characteristic of a gel system; compared with the traditional hydrogel, the eutectic gel can effectively improve the drug transdermal efficiency without adding a chemical penetration enhancer, has excellent cold-resistant and heat-resistant stability, is simple in preparation process and good in biocompatibility, and has a wide clinical application prospect in the aspect of treating skin diseases such as skin itch and psoriasis.

The invention discloses a ramosetron patch composition, a ramosetron patch as well as a preparation method and application of the ramosetron patch, and belongs to the technical field of patches. The technical problem to be solved is to improve long-acting percutaneous penetration effect and sensory adhesion performance and reduce allergy and irritation. According to the key point of the technical scheme, the ramosetron patch composition is prepared from the following components in parts by weight: 3 to 20 parts of medicine; 30-75 parts of a matrix material; the medicine comprises any one of ramosetron and pharmaceutically acceptable salts of ramosetron or a combination of the ramosetron and the pharmaceutically acceptable salts of ramosetron; the matrix material is prepared by compounding a hydroxyl acrylate pressure-sensitive adhesive and a carboxyl acrylate pressure-sensitive adhesive.

The invention relates to the technical field of skin care products, and particularly discloses a high-activity collagen skin care product based on a pharmaceutical-grade process and a preparation method thereof.The preparation method of the skin care product comprises the steps that collagen is dispersed in deionized water and then subjected to low-temperature directional enzyme digestion and medium-temperature deep enzymolysis, and a collagen peptide solution is obtained; and adding a polyhydroxy polymer and an auxiliary gelling agent, carrying out ultrasonic treatment to obtain composite nano sol, adding a cross-linking agent, carrying out a reaction, quenching, carrying out ultrafiltration purification, and adjusting the pH value to obtain the high-activity collagen skin care product based on the pharmaceutical-grade process. According to the preparation method disclosed by the invention, the problems that the collagen is easy to inactivate and difficult in transdermal penetration are effectively solved through the cooperation of an ultrasonic cavitation effect and a nano coating technology, meanwhile, the pharmaceutical-grade purity (greater than or equal to 96%) and the biological safety of the product are ensured by utilizing a precise enzymolysis and safe crosslinking process, and effective penetration and long-acting active release of the collagen in a DEJ layer of the skin are realized.

This invention belongs to the field of biomedical technology and discloses a non-denatured type I and III collagen ultrafine powder with deep skin growth and three-dimensional repair effects, its molecular protection preparation method, and multiple application pathways. The ultrafine powder contains 50%-70% non-denatured type I collagen, 15%-30% non-denatured type III collagen, 5%-15% molecular protectant, 3%-10% transdermal penetration enhancer, and 2%-8% bioactive stabilizer. The mass ratio of type I to type III collagen is 7:3 to 8:2, the triple helix retention rate is not less than 85%, and the average particle size is 0.5-3 μm. The preparation method employs low-temperature enzymatic extraction and molecular protection complexation technology to achieve complete preservation of the collagen triple helix structure. The product can be applied through surface application, microneedle delivery, and injection to meet the needs of skin repair at different depths.

The invention discloses a traditional Chinese medicine composition for relieving whole body pain. The traditional Chinese medicine composition is prepared from the following raw materials: a medicine component A, a medicine component B, a medicine component C and auxiliary materials, the medicine component A is a composition for easing pain and activating blood, the medicine component B is an auxiliary synergistic composition, the medicine component C is a synergistic conditioning composition, and the auxiliary material is a transdermal penetration enhancing and synergistic composition. Compared with the prior art, the traditional Chinese medicine composition for relieving the pain of the whole body and the preparation method have the advantages that the traditional Chinese medicine composition is complete in effect and small in harm to the body.

The application belongs to the field of textiles, and discloses a fabric for adjuvant therapy of breast cancer and a preparation method thereof. The preparation method comprises the following steps: firstly, preparing a fluorouracil FU and collagen tripeptide CTP compound FU-CTP, incorporating the compound into a core layer spinning solution, preparing a core-shell nanofiber membrane through electrospinning, and finally obtaining the fabric for adjuvant therapy of breast cancer. The fabric can release the compound FU-CTP in the form of micelles, CTP can carry FU, promote the transdermal penetration ability of FU, and enrich FU in the local breast to reach a therapeutic concentration, so that most side effects such as gastrointestinal side effects and bone marrow suppression caused by oral and intravenous administration of FU can be reduced.

The invention relates to a method for analyzing the transdermal permeation content and distribution of cosmetic active ingredients, which comprises the following steps: smearing the cosmetic containing the active ingredients on artificial skin for permeation treatment, and freezing and slicing to obtain a sample; the method comprises the following steps: acquiring data by adopting a desorption electrospray ionization mass spectrometry imaging technology, and extracting a peak table containing position, mass-to-charge ratio and intensity information; performing normalization processing on the target object intensity of each pixel point by taking the mass locking internal standard object as a reference to generate a normalized mass spectrum imaging graph; identifying a skin tissue area by using the endogenous characteristic substance signal distribution of the skin and adopting an image segmentation algorithm; the average normalized intensity of the target object in the area is calculated to quantify the permeability content difference, and the distribution uniformity is evaluated through a variable coefficient. Compared with the prior art, the method can accurately quantify the content change of the target object under different conditions, and supports the relative content analysis and distribution uniformity analysis of the target object in the data acquired within the day and during the day in a long range.

The invention relates to the technical field of noninvasive medical imaging, acousto-optic coupling and targeted drug delivery, and discloses a lesion finding and positioning and targeted drug guiding system and method based on an acousto-optic coupling functional film layer. Based on intelligent processing equipment with acoustics, optics and signal processing capacity, non-invasive discovery and accurate fault positioning of human tissue / body fluid lesions and directional guidance and local enrichment of targeted drugs are achieved in a time-sharing mode through the same physical area of the same acousto-optic coupling integrated functional film layer. The membrane layer multiplies the frequency of a low-frequency signal of 20Hz-20kHz into medical ultrasound of 2MHz-10MHz to complete imaging positioning, and meanwhile, targeted drug guidance such as optical / acoustic power, magnetic targeting and ultrasonic transdermal infiltration promotion is realized through the special optical / energy conducting layer, so that the drug focus enrichment rate is increased, and the side effects of the whole body are reduced. Equipment hardware does not need to be transformed, the film layer is flexible in form and wide in adaptability, medical diagnosis and treatment functions are integrated into consumer electronic equipment for the first time, low-cost popularization is achieved, and the system is suitable for targeted drug treatment guidance of various lesions such as solid tumors, virus infection lesions and chronic inflammation lesions, can be applied to multiple scenes such as families, primary medical treatment and hospitals and has wide application prospects. And the method has the remarkable advantages of high precision, noninvasive safety and the like.

The application belongs to the technical field of cosmetics, and discloses a high-stability soothing functional composition and a preparation method and application thereof. The composition comprises active functional components, a natural stable carrier, a natural preservative system and a cosmetically acceptable aqueous base, wherein the active functional components are inclusion EGCG, microcapsule-encapsulated chamomile extract and phospholipid-complexed calendula extract, and a full-natural broad-spectrum preservative system is constructed in a matched manner. Through the synergistic use of triple stabilization technology, the application solves the industry pain points that natural soothing active ingredients are prone to oxidation inactivation, have poor dispersibility, low bioavailability and traditional preservatives are prone to irritating sensitive skin, greatly improves the storage stability and transdermal penetration effect of the active ingredients, and the product is mild and non-irritating, is suitable for industrial large-scale production, and can be widely applied to the preparation of anti-allergy soothing and skin barrier repair cosmetics.

The utility model relates to penetration enhancer accessories and instruments in the technical field of micro-needle transdermal penetration enhancement, in particular to a pressure sensing device and a penetration enhancer. The pressure sensing device comprises an outer cylinder, and a limiting groove is formed in the outer cylinder; the inner cylinder is sleeved with the outer cylinder, and a limiting buckle is arranged on the inner cylinder; the inner cylinder is also provided with a control part; an elastic piece is connected between the inner cylinder and the outer cylinder; the pressure sensing device further comprises a prompting element, a first element and a second element which are electrically connected, the first element is fixedly arranged in the outer cylinder, and the second element is movably arranged in the outer cylinder and connected with the control part; when no external force is applied, the first element is separated from the second element so that the circuit of the prompting element is disconnected. When the inner cylinder moves relative to the outer cylinder under the action of external force, the control part drives the second element to contact with the first element, and the circuit of the prompting element is switched on. The pressure sensing device can sense the contact pressure between the penetration enhancer and the skin in real time and remind a user of the use force.

The invention discloses a high-permeability modified collateral-activating traditional Chinese medicine transdermal patch and a preparation method thereof, and belongs to the field of traditional Chinese medicine preparations. The patch consists of a backing layer, a medicine skeleton layer and an anti-sticking layer, the medicine skeleton layer comprises a modified collateral activating effect prescription medicine extract, a composite transdermal promotion system, a tackifying modifier, a cross-linking agent and a polymer matrix material; according to the invention, an azone-borneol / menthol eutectic mixture-propylene glycol quaternary composite permeation promoting system is created for the first time, and through complementation and synergy of different permeation promoting mechanisms, the problem of synchronous and efficient transdermal penetration of multiple components and active ingredients with different polarities in the modified collateral activating effect prescription is successfully solved; the transdermal rate is obviously improved compared with that of a traditional single or binary infiltration promotion system; the acrylate pressure-sensitive adhesive is synergistically modified by hydrogenated rosin glyceride and aluminum acetylacetonate, and is assisted by a curing process, so that the balance of initial adhesion and cohesion is realized, the patch has the characteristics of firm adhesion, durability and thorough uncovering, and the compliance of a patient is improved.

The application discloses a traditional Chinese medicine transdermal penetration acupoint plaster for treating AECOPD and a preparation method thereof, wherein kaolin, carbomer and CMC-Na are mixed and ground uniformly, glycerol is ground and then added with water to grind finely, and the mixture is placed overnight; gelatin is placed in water and placed for 8-12 minutes to make it swell fully, and then the gelatin is dissolved in water bath at 55-65 DEG C to obtain a gelatin solution; the gelatin solution and the mixture are mixed, and traditional Chinese medicine extracts are added into the mixture for multiple times while hot to mix into a paste, which is coated on a non-woven fabric backing and dried in an oven at 55-65 DEG C for 5-8 hours to obtain the traditional Chinese medicine transdermal penetration acupoint plaster for treating AECOPD; 10-20 parts of ginseng, 8-12 parts of ephedra, 8-12 parts of baizhi, 2-5 parts of xiaocin, 8-15 parts of banxia and 8-15 parts of ginger are decocted with alkaline water with pH of 8.5-9.0, and the water decoction is alcohol precipitated and concentrated into a thick paste to obtain the traditional Chinese medicine extracts. The prepared plaster has the advantages of good skin compatibility, affinity, air permeability, sweat resistance, drug release, permeability and repeated peeling, and can be quickly applied to relieve symptoms for acute patients without adverse reactions.

The application discloses a kind of compositions for promoting macromolecular hydrophilic active substances to penetrate skin and application thereof, the composition includes the following components by mass percentage: 5-10% bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester, 5-10% diethoxyethyl succinate, 0.7-1.4% silk fibroin, 5-10% polyol and the balance water.The application of the composition in the preparation of cosmetics has the effect of promoting macromolecular hydrophilic active substances to penetrate skin.The specific preparation method is: at 20-30 DEG C, the composition is mixed and stirred uniformly to obtain a premix;purified water and macromolecular hydrophilic active substances are added to the premix and stirred uniformly to obtain a mixture;the mixture is subjected to high-pressure homogenization or high-speed shearing treatment, and the temperature of the mixture is controlled to be not higher than 30 DEG C to obtain a final product.The application can realize faster and more penetration of macromolecular hydrophilic active substances to deeper layers of skin.

The invention relates to medical cold compress gel for improving gout and a preparation method of the medical cold compress gel. The medical cold compress gel comprises the following components in percentage by weight: (1) a cooling matrix material: 0.5-2% of carbomer, 5-15% of glycerol and 3-8% of propylene glycol; (2) natural anti-inflammatory components: 1-3% of a radix scutellariae extract and 0.5-1.5% of asiaticoside; (3) a uric acid inhibitor: 0.2%-1% of apigenin nano-liposome and 0.1%-0.5% of chicoric acid; (4) a transdermal penetration enhancer: 1-3% of azone and 0.5-2% of menthol; and the balance of deionized water. The invention has the following beneficial effects: 1, physical-chemical synergistic effect: red and swollen can be relieved by cold compress, and inflammatory factors such as IL-1beta, TNF-alpha and the like can be inhibited by the active components; 2, targeted inhibition of uric acid: apigenin nano-liposome enhances transdermal absorption and inhibits the activity of xanthine oxidase; 3, the safety is high: the systematic side effects of the traditional medicine are reduced by the natural components;

The invention provides an oil-soluble polypeptide composition containing camellia polypeptide and having a cellular-grade anti-aging effect as well as a preparation method and application of the oil-soluble polypeptide composition, and particularly relates to the technical field of cosmetic intermediates. The outside of the oil-soluble polypeptide composition is coated with a phospholipid membrane, and a polypeptide-supramolecular complex is embedded into the phospholipid membrane; the polypeptide-supramolecular complex is obtained by coating a supramolecular solution of polypeptide with first phospholipid and then freeze-drying. The oil-soluble polypeptide composition realizes efficient solubilization and stable loading of polypeptide in a pure oil system. Polypeptide is dissolved by a supramolecular solvent and freeze-dried to form a polypeptide-supramolecular complex, so that exposure of hydrophilic groups of the polypeptide-supramolecular complex is remarkably reduced, and fat solubility is improved; the outer phospholipid membrane not only forms a compact hydrophobic protective barrier, effectively isolates a water-phase environment, inhibits degradation reactions such as hydrolysis and oxidation of polypeptide and improves chemical stability and shelf life, but also serves as a lipid material with excellent biocompatibility, enhances affinity of the composition and a skin cuticle lipid structure and synergistically promotes transdermal permeation of polypeptide.

The application discloses a kind of nanometer composition for scalp deep anti-inflammatory and improving hair follicle environment and its preparation method and application.The composition is made of nanometer ascorbic acid palmitate 5-10 parts, liposome VC 3-8 parts, menthol 15-25 parts, collagen 5-10 parts, vitamin B6 2-4 parts, zinc 0.5-1 part.The application significantly enhances the transdermal penetration of active ingredients by nanotechnology;Synergistic effect of each component can effectively inhibit the growth of malassezia, reduce the expression of inflammatory factors IL-6 and TNF-α, promote the production of type I collagen, realize scalp deep anti-inflammatory and hair follicle repair.Experiments show that the bacteriostatic effect of the composition is significantly better than that of commercially available products, and the anti-inflammatory and repair effect is equivalent to that of positive control, and the total effective rate reaches 88.3%.The application is safe and non-irritating, and is suitable for hair care products such as shampoo and hair conditioner.

The application discloses an active composition for treating atopic dermatitis and application thereof, and belongs to the technical field of biological medicine. The application uses a specific proportion of (+)-catechin hydrate, epicatechin, chlorogenic acid and coniferyl alcohol as active ingredients, so as to play a synergistic effect of multi-target and multi-pathway, and achieve the effect of treating atopic dermatitis. In addition, the composition of the carrier is optimized, the stability, skin permeability and slow-release performance of the active ingredients are improved, the transdermal penetration and target site accumulation of the active ingredients are enhanced, the local drug concentration and the persistence of the curative effect are improved, the active ingredients have better bioactivity under low temperature, various local external dosage forms such as gels, creams, dressings and sprays can be prepared according to the clinical needs, the application is flexible, the adverse reactions caused by long-term use of traditional hormone drugs or chemical synthetic drugs can be avoided, and the application has a good industrial transformation prospect.

This invention discloses a soothing, penetration-promoting, and moisturizing lip composition, its preparation method, and its application, belonging to the field of cosmetic technology. The composition, by weight, comprises 50.0-80.0 parts of base oil, 1.0-5.0 parts of ginger root oil, 0.2-1.0 parts of *Edelweiss* callus extract, 0.1-1.5 parts of bisabolol, 2.0-5.0 parts of polyglycerol-3 diisostearate, and 0.5-5.0 parts of hydrogenated lecithin. The components synergistically enhance each other, achieving excellent comprehensive performance in transdermal penetration promotion, moisturizing, and soothing. The composition is non-irritating to the lip mucosa, contains no traditional preservatives, and has good safety performance. The preparation process of this composition is simple, suitable for industrial production, and can be used to prepare various lip cosmetics.

The invention relates to the technical field of medicines, and particularly discloses a novel plaster matrix imitating a traditional plaster. The plaster matrix comprises a thermoplastic elastomer, silicone gel, hydrogenated rosin resin, an acrylate copolymer, a transdermal absorption enhancer, a plasticizer, a filler, a stabilizer and vaseline, and the components cooperate to construct a matrix system; the preparation method comprises the following steps: firstly melting the thermoplastic elastomer and the like to prepare a matrix mixture, preparing the silicone gel and the like into an auxiliary mixture, compounding and mixing, adding the filler and the stabilizer, performing high-shear emulsification, and finally coating, performing ultraviolet curing, cooling and slitting. The plaster matrix disclosed by the invention can be used as a carrier of an external plaster, and has the advantages of good adhesion, good air permeability, excellent flexibility and capability of assisting medicine transdermal penetration; in addition, the preparation method provided by the invention has the advantages of uniform component dispersion, strong process controllability and capability of guaranteeing stable matrix performance, and is suitable for large-scale production of the plaster matrix.