Transdermal drug delivery preparation with three-dimensional mesh stereoscopic configuration and preparation method of transdermal drug delivery preparation

A three-dimensional network and three-dimensional configuration technology, which is applied in the directions of pharmaceutical formulations, medical preparations of inactive ingredients, and sheet delivery, etc. Problems such as easy precipitation and crystallization effect
CN104546804AInactive Publication Date: 2015-04-29SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI MODERN PHARMA ENG INVESTIGATION CENT
Publication Date
2015-04-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a transdermal drug delivery preparation with three-dimensional mesh stereoscopic configuration and a preparation method of the transdermal drug delivery preparation. The transdermal drug delivery preparation with the three-dimensional mesh stereoscopic configuration is composed of a transdermal drug delivery system with the drug-loaded three-dimensional mesh stereoscopic configuration, a backing layer and an anti-sticking layer, wherein the backing layer is compounded on one side of the transdermal drug delivery system with the drug-loaded three-dimensional mesh stereoscopic configuration; and the anti-sticking layer is compounded on the other side of the transdermal drug delivery system with the drug-loaded three-dimensional mesh stereoscopic configuration. With nanoporous silica as a carrier, the defects that a preparation is low in drug loading capacity, medicines are easily separated out and crystallized to affect the transdermal absorption efficiency, the adhesion performance of a pressure-sensitive adhesive system is not ideal enough, the pressure-sensitive adhesive system is easy to age, and the medicine stability is poor are solved; the long-term lasting transdermal penetration of the medicine can be effectively achieved; the stable blood concentration can be maintained; and the preparation has the characteristics of high transdermal absorption rate, high transdermal absorption amount, stability and high efficiency.
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Description

technical field

[0001] The invention relates to a three-dimensional network three-dimensional transdermal drug delivery system with nanoporous silicon dioxide as a carrier and a preparation method thereof. Background technique

[0002] Transdermal drug delivery preparation is a sustained and controlled release preparation in which the active drug is absorbed into the blood circulation of the whole body through the skin and has a therapeutic effect. The transdermal drug delivery preparation is composed of an active ingredient and a carrier. In addition to the performance of the ingredients, it is mainly determined by the carrier used to load the active ingredients.

[0003] At present, the carriers of conventional transdermal drug delivery preparations, such as the pressure-sensitive adhesive matrix transdermal drug delivery systems disclosed in patents CN1269717A and CN101229144A, all have low drug loading, easy crystallization of drugs, and influence on transdermal absorpti...

Claims

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