752 results about "Transdermal absorption" patented technology

The invention belongs to the technical field of protein engineering and biology, and discloses a recombinant III-type humanized collagen, a coding gene thereof, a protein preparation, a preparation method of the protein preparation, application of the protein preparation and a skin care product. The amino acid sequence of the recombinant III type humanized collagen is as shown in SEQ ID NO. 1. According to the recombinant III type humanized collagen, the transdermal absorption efficiency is greatly improved, and meanwhile, the proliferation and migration capabilities of keratinocytes are also remarkably improved. The collagen is widely applied to the fields of medical cosmetic plastic surgery, cosmetics and the like, and has a good application prospect.

The invention provides an intelligent response type medical liquid application and a preparation method thereof, and relates to the technical field of medical dressings. The liquid application is composed of a basic repairing component, a natural antibacterial component, a plant active component, an intelligent carrier system and auxiliary materials. Accurate release of active ingredients is realized by adopting a pH / temperature double-response intelligent delivery system, and the transdermal absorption rate is remarkably improved; wound healing is accelerated through the synergistic effect of the compound protein and the plant extract; active ingredients are effectively reserved through a multi-mode sterilization process. The liquid application disclosed by the invention has the characteristics of strong antibacterial property, good environmental adaptability, excellent healing effect and the like.

The invention provides a composition for promoting hair regeneration after chemotherapy as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method comprises the following steps: modifying the surface of a gold nanocage with polydopamine, loading the modified gold nanocage on an exosome, complexing magnesium ions and zinc ions to prepare a modified exosome, preparing a nano drug-loaded liposome from curcumin, resveratrol and epigallocatechin gallate, mixing the nano drug-loaded liposome with the modified exosome to prepare a multi-layer liposome, and preparing the multi-layer liposome from the nano drug-loaded liposome. And mixing with a penetration enhancer, and adding into a temperature-sensitive hydrogel system to prepare the composition for promoting hair regeneration after chemotherapy. The composition for promoting hair regeneration after chemotherapy has a good transdermal absorption promoting effect, can slowly release drugs, promotes hair follicles to be converted from a resting stage to a growing stage under the synergistic effect of the drugs, regulates and controls multiple pathways (such as anti-apoptosis, angiogenesis promotion and anti-inflammation) at the same time, is matched with a complex pathological mechanism of hair regeneration after chemotherapy, and can promote hair regeneration after chemotherapy. Wide application prospects are realized.

The invention relates to the field of nano-drug delivery preparations, in particular to a traditional Chinese medicine transdermal drug delivery preparation based on a nano-coating technology and a preparation method thereof, the traditional Chinese medicine transdermal drug delivery preparation comprises a liposome-metal organic framework composite carrier, and the composite carrier comprises traditional Chinese medicine active ingredients; a meridian point targeted transdermal enhancer; an iontophoresis device for dynamically sensing skin impedance; the invention relates to an intelligent administration time sequence control system based on a traditional Chinese medicine midnight-noon ebb-flow theory. The liposome-metal organic framework composite carrier is adopted, the similar structure of liposome and skin and the high specific surface area of MOF are fully utilized, efficient encapsulation and transdermal absorption of active ingredients of traditional Chinese medicine are achieved, and compared with a traditional transdermal patch, the drug transdermal absorption rate is increased by 3-5 times.

The invention relates to the technical field of cosmetics, and discloses an anti-inflammatory soothing cosmetic composition which comprises the following components in percentage by weight: 0.5%-4% of a barrier repairing component, 0.5%-3% of an immunoregulation component, 0.3%-2.5% of a nerve soothing component, 0.3%-3% of an anti-inflammatory plant compound, 1%-10% of a moisturizing soothing enhancer and the balance of auxiliary materials. According to the components, through a five-dimensional synergistic mechanism of barrier repair, immune tolerance, nerve desensitization, anti-inflammatory itching relieving, moisturizing and stability maintaining, anti-inflammatory relieving and barrier repair are remarkably enhanced; ceramide, rare ginsenoside, phytosterol ester and free fatty acid are introduced to synergistically construct a bionic liposome which is closer to the composition of human cuticle lipid, so that the transdermal absorption and stability are enhanced, and the repair efficiency is remarkably improved; the dipotassium glycyrrhizinate, the tamarix chinensis flower extract, the purslane extract, the dinoflaxanthine and the baicalin cooperate to quickly resist inflammation and relieve itching and strengthen barrier repair, so that the composition is suitable for highly sensitive skin.

The invention discloses an anti-aging face cream suitable for sensitive skin and a preparation method of the anti-aging face cream. The anti-aging face cream comprises 1-10 wt% of a supramolecular eutectic compound, 10-30 wt% of an auxiliary material and the balance of deionized water, the supramolecular eutectic compound comprises an anti-aging component, a supramolecular eutectic agent and Neosol-Aqulio, wherein the supramolecular eutectic agent is used for forming a supramolecular eutectic with the anti-aging component, and the Neosol-Aqulio is dispersed in the supramolecular eutectic; wherein the anti-aging component comprises oleuropein and hydroxytyrosol, and the supramolecular eutectic agent is nicotinamide, or a mixture of capryloyl glycine and betaine. Neosol-Aqulio, a supramolecular eutectic agent and an anti-aging component are utilized to form a supramolecular eutectic, so that active component delivery is facilitated, efficient transdermal absorption is realized, permeability, stability and mildness of the anti-aging active component are improved, the problem of sensitive skin cuticle permeation is solved, irritation of a traditional penetration enhancer is avoided, and the penetration enhancer is suitable for clinical application. The double effects of efficient permeation and mild anti-aging are realized.

The invention belongs to the technical field of biological medicine, and particularly relates to a luliconazole composition containing essential oil, cream and a preparation method and application of the luliconazole composition. The present application provides a composition containing tea tree essential oil that promotes the skin permeability of luliconazole and has an antibacterial function, the tea tree essential oil and luliconazole form a synergistic antifungal effect, the transdermal absorption is enhanced by a natural terpene component, and the irritation to the skin is significantly reduced.

This invention provides an anti-aging and repairing composition containing collagen and its preparation method, belonging to the technical field of medical, dental, or cosmetic products. Its components consist of hydrolyzed collagen, recombinant type III human collagen, artichoke leaf extract, and fermented blueberry seed oil. This invention uses recombinant type III human collagen and hydrolyzed collagen as its core, overcoming the limitations of traditional collagen through biotechnology, and supplementing it with double-fermented plant ingredients to solve the bottlenecks of transdermal absorption and anti-oxidation. The overall design conforms to the anti-aging triangle logic of "repair, defense, and moisturizing," and has good market prospects.

The invention relates to the technical field of medicine formulas, in particular to a fluralamide moxidectin composite drop and a preparation process thereof. The invention relates to a fluralan-moxidectin emulsion which is prepared from the following raw materials in percentage by mass: 26 to 30 percent of fluralan, 1.1 to 1.7 percent of moxidectin, 32 to 36 percent of solvent, 0.1 to 0.3 percent of butylated hydroxytoluene, 10 to 16 percent of polymer carrier and the balance of tetrahydrofuran polyethylene glycol ether. The coexisting drug is stabilized through the core-shell structure polymer carrier, phase separation is prevented, a neutral environment is maintained, long-acting stability is ensured, the transdermal absorption rate is optimized, skin irritation is reduced, and the synergistic drug effect is improved. Meanwhile, the slow release period of the medicine is prolonged, the metabolic interference and accumulated toxicity are reduced, and the dissolution efficiency and the skin mildness are both considered.

The invention belongs to the technical field of cosmetics, and particularly relates to a skin-color-uniformizing whitening composition derived from plant extracts and application of the skin-color-uniformizing whitening composition. The whitening composition provided by the invention is prepared from the following components in parts by weight: 10 to 15 parts of saussurea involucrata extract, 1 to 8 parts of dendrobium officinale extract, 1 to 5 parts of wood apple extract and 0.5 to 5 parts of banana fruit extract. The four plant extracts are synergistically compounded, transdermal absorption of active ingredients can be promoted, the tyrosinase inhibition rate is effectively increased, and the skin glossiness and whiteness are improved, so that the effects of whitening, brightening and uniformizing the skin color are achieved, the whitening composition is mild and non-irritant, the preparation method is simple and convenient to operate, and the whitening composition has large-scale production capacity and industrial feasibility. When the whitening composition is applied to skin care products such as face cream, the whitening and brightening effects of the face cream can be effectively improved, and the whitening composition has wide market application value.

The invention discloses a plant composition with skin anti-aging activity and a preparation thereof. The plant composition is prepared from the following active ingredients in percentage by weight: 84.0 to 89.0 percent of haematococcus pluvialis extract, 8.0 to 12.0 percent of lithospermum oil, 0.5 to 0.8 percent of melaleuca alternifolia leaf oil, 0.5 to 1.0 percent of hydrolyzed olive leaf extract, 0.1 to 0.5 percent of rhodiola rosea root extract and 1.2 to 2.5 percent of bitter orange leaf oil. The plant composition with the skin anti-aging activity is used as an effective component, other auxiliaries are added, and emulsion, cream or essence oil is prepared. According to the plant composition and the preparation, the fermented camelina seed oil, the fermented safflower seed oil, the fermented meadowfoam seed oil and the like are used as solvents for extracting active components in haematococcus pluvialis and are also used as functional components and matrixes of the preparation, and compared with application of original plant oil, the plant composition and the preparation have better skin feeling and biological activity; the extraction rate of active ingredients in haematococcus pluvialis is higher, and transdermal absorption of the active ingredients is facilitated.

The invention relates to the technical field of pharmaceutical preparations, and provides a minoxidil film coating agent as well as a preparation method and application thereof. The minoxidil film coating agent provided by the invention comprises 40-60% of propylene glycol, 3-7% of polyvinyl alcohol, 20-30% of ethanol, 1-7% of minoxidil and the balance of water. According to the invention, propylene glycol is taken as a solvent, a plasticizer and a transdermal absorption enhancer, polyvinyl alcohol is taken as a film-forming material, and ethanol is taken as a volatile agent, after administration, ethanol is volatilized to promote film formation of polyvinyl alcohol, and propylene glycol enhances the plasticity of the formed film, so that the effect of reducing liquid medicine loss is achieved, the local medicine concentration is increased, and the bioavailability is improved. The minoxidil liniment disclosed by the invention has excellent skin permeability, can effectively convey a medicine to a required part, and can ensure that the medicine is released at a fixed position of the skin and is accurately administered in a medicine release process, so that the stimulation of liquid medicine flow to other parts is reduced, and a good treatment effect is achieved.

The invention discloses a lipophilic liposome containing polydeoxyribonucleotide as well as a preparation method and application of the lipophilic liposome. The lipophilic liposome comprises the following components in parts by weight: 0.001-3 parts of polydeoxyribonucleotide; 0.5 to 3 parts of phospholipid; 0.1-2 parts of a cationic emulsifier; 0.1-3 parts of an anionic emulsifier; 40 to 70 parts of polyol; the total amount is 100 parts. According to the invention, an emulsifier system formed by combining lecithin with anionic and cationic compound surfactants is adopted, so that the transdermal absorption of PDRN is facilitated. The lipophilic liposome containing polydeoxyribonucleotide prepared by the invention can effectively resist nuclease degradation, prolong the acting time of PDRN in skin, and improve the skin anti-aging and repairing effects of the liposome. The anti-aging effect of the active ingredients is improved, and the bioavailability of the active ingredients is improved. The cosmetic composition can be widely applied to cosmetic formulas of various dosage forms.

The invention relates to a glabridin self-assembly inclusion with an ultra-small particle size as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The composition disclosed by the invention is prepared from the following components in parts by weight: 0.5 to 5 parts of glabridin, 10 to 30 parts of polyhydric alcohol, 0.4 to 6.5 parts of liquorice root carrier component, 1.5 to 3 parts of nonionic emulsifier A, 0.45 to 1.8 parts of nonionic emulsifier B and 53.7 to 87.15 parts of water, the liquorice carrier component comprises at least one of glycyrrhizic acid, ammonium glycyrrhizinate and glycyrrhetinic acid; the nonionic emulsifier A is a nonionic emulsifier of which the hydrophilic-lipophilic balance value HLB is greater than 9; and the nonionic emulsifier B is a nonionic emulsifier with a hydrophilic-lipophilic balance value HLB of 2-4. The glabridin self-assembly inclusion disclosed by the invention is smaller in particle size, good in wrapping performance and good in targeting property; the stability is good, glabridin wrapping does not separate out, and the transdermal absorption rate is higher.

The present application provides a recombinant human type III collagen with high thermal stability and high transdermal permeability. The recombinant type III collagen comprises a type III collagen part and a transdermal peptide part, which has a high transdermal absorption capacity and has the advantage of high thermal stability, and is suitable for the preparation of cosmetics, drugs and medical devices.

The invention provides liquiritin gel as well as a preparation method and application thereof. The liquiritin gel is prepared from the following components in concentration: 0.1 weight percent to 2 weight percent of liquiritin, 0.1 weight percent to 4 weight percent of carbomer, 0.1 weight percent to 4 weight percent of water-soluble cellulose ether compounds and 1 to 10 mL / Kg of triethanolamine. Wherein liquiritin and the water-soluble cellulose ether compound are respectively used as a main thickening agent and an auxiliary thickening agent, a synergistic thickening system is more stable and more suitable for liquiritin compared with a single thickening system or other neutralization systems, and the liquiritin and the water-soluble cellulose ether compound can synergistically adjust viscosity; triethanolamine is used as a neutralizer to neutralize carboxyl of carbomer to form gel; carbomer and a water-soluble cellulose ether compound are cooperated according to a specific ratio and can be different from a single thickening system or different neutralization systems, so that the liquiritin gel with excellent film-forming property, proper flowability and high transdermal absorption efficiency is prepared.

The invention relates to the technical field of lipidosome compounds, in particular to a cosmetic lipidosome compound with an anti-allergy effect and a preparation method of the cosmetic lipidosome compound. The preparation method of the cosmetic liposome compound with the anti-allergy effect comprises the steps of preparation of a wrapping modification modifier, preparation of wrapping modification liposome and preparation of the cosmetic liposome compound. Efficient allergy relieving is achieved through the synergistic effect of the hovenia dulcis thunb extract and the white willow bark extract. The former inhibits release of inflammatory factors and scavenges free radicals, the latter reduces synthesis of prostaglandin and promotes epidermal renewal, and the former and the latter form a dual anti-inflammatory network, cooperate with lipid, regulate water and oil and accelerate inflammation regression. Meanwhile, the two extracts are wrapped by lipidosome, and a modifier formed by zein and fucoidin is combined, so that the stability of the lipidosome is enhanced, the percutaneous delivery efficiency and the percutaneous absorption effect of the components are improved through multiple effects, and it is ensured that the active components effectively exert the anti-allergy effect.

The present invention relates to the technical field of daily chemical technology, and specifically provides a whitening and freckle-removing cream. The freckle-removing cream comprises the following components in parts by weight: water, glycerin, mineral oil, antioxidant microcapsules, polydimethylsiloxane, sodium ascorbyl phosphate, niacinamide, a plant compound extract, essence, and cetearyl alcohol. The present invention adds natural plant extract ingredients, which is safe and effective. A circulation device is used to promote the effective combination of active ingredients, so that the active ingredients can quickly penetrate into the inner layer of the skin, thereby improving the transdermal absorption ability of the active ingredients. A unique encapsulation technology is used to firmly adhere the active ingredients to the skin surface, thereby effectively lightening facial spots, removing dullness from the skin, and restoring luster.

The invention provides moisturizing and anti-wrinkle cream and a preparation method thereof. The moisturizing and anti-wrinkle cream is prepared from the following raw materials in percentage by mass: 2%-10% of fibroin composite microsphere solution, 2%-5% of skin conditioner, 1%-2% of emollient, 8%-15% of humectant, 0.1%-1% of emulsifier, 1%-2% of emulsion stabilizer, 0.1%-0.2% of thickener and the balance of water. Wherein the fibroin composite microsphere is a spherical aggregate obtained by interpenetrating and entangling fibroin and poly-desoxyribonucleic acid in a cation environment and folding and compressing the fibroin and the poly-desoxyribonucleic acid; the composite microspheres can be percutaneously absorbed, and when the composite microspheres are applied to a formula of cream, the percutaneous permeation efficiency of the cream is greatly improved, and the moisturizing and anti-wrinkle effects of the cream are improved.

The invention relates to a preparation method and application of a blue copper peptide-PDRN composite freeze-dried efficacy core sphere steady-state delivery system, and belongs to the technical field of cosmetics. The invention provides a composite freeze-dried functional core sphere steady-state delivery system of a combination of blue copper peptide, PDRN and macromolecular active ingredients, an ordered and stable nano-assembly steady-state structural system is formed through multiple interaction among blue copper peptide, PDRN and macromolecules, and the problems of stability and compatibility of blue copper peptide are solved; secondly, a composite freeze-dried functional core ball based on a copper-blue peptide liposome inclusion compound is developed, and the transdermal absorption rate of copper-blue peptide is improved; thirdly, the blue copper peptide functional core ball based on excellent transdermal absorption rate is developed; finally, a processing technology for producing a blue copper peptide composite freeze-drying efficacy core sphere steady-state delivery system at low temperature in a whole process based on liquid nitrogen quick freezing is developed.

The invention discloses a medicine for treating bedsore and application thereof.The medicine is prepared from parthenocissus tricuspidata, clove, radix aucklandiae and borneol, the parthenocissus tricuspidata serves as a monarch drug and has the effects of promoting blood circulation, removing toxins, removing blood stasis, dredging collaterals, improving local blood circulation of bedsore, promoting inflammation fading, dissolving sore and ulcer toxins and repairing damaged tissue; the clove is used as a ministerial drug to expel pus and engender tissue, inhibit wound infection and promote healing of ulcerated wounds; the radix aucklandiae is used as an adjuvant drug for promoting qi circulation, promoting blood circulation and promoting qi hyperactivity and blood circulation, and the radix aucklandiae is used as a monarch drug for removing stasis and dredging collaterals to nourish tendons and meat; borneol is used as an assistant drug, is used for resisting bacteria, relieving pain and promoting healing of non-healing after bedsore ulceration, and also can be used as a meridian guiding drug to enhance the seepage force of the drug so as to promote external transdermal absorption of the drug. Through simple composition and reasonable compatibility of the medicines, local qi and blood stasis of bedsores can be improved and wound healing can be promoted through the multi-target effect by activating blood and detoxifying, expelling pus and promoting tissue regeneration and inhibiting bacteria to control infection, so that the bedsores can be effectively treated.

The invention belongs to the technical field of sleep-aiding gels, and discloses a herbal sleep-aiding gel and a preparation process thereof, the gel comprises the following components: deionized water, propylene glycol, glycerol, carbomer 980 and triethanolamine; the mask is prepared from, by weight, 1.8% of lavender essential oil, chamomile extract, bitter orange flower essential oil, gamma-aminobutyric acid, melatonin, spina date seed extract, xylaria nigripes extract and phospholipid wall materials. Sodium chloride and azone; camphor and borneol; eDTA (Ethylene Diamine Tetraacetic Acid) disodium, phenoxyethanol and ethylhexylglycerin. The traditional Chinese medicine composition is suitable for people with sleep disorders such as long-term insomnia, difficulty in falling asleep, insomnia and dreaminess, easy awakening due to light sleep, restlessness and depression and the like; through the high transdermal absorption rate of a nano micro-capsule technology, in combination with a colloid double-electrode-layer structure, capacitance-like micro-current is generated, in cooperation with lavender-chamomile-bitter orange flower and other herbal essence and GABA and melatonin active ingredients, the sleep center is adjusted in a multi-channel mode, and the physical sleep-aiding scheme is a new physical sleep-aiding scheme for safely replacing a sleeping drug.

The invention relates to the technical field of cosmetics and transdermal drug delivery, in particular to a resveratrol-tocoxolam nano-micelle and application of the resveratrol-tocoxolam nano-micelle in preparation of antioxidant and skin whitening products. The preparation method comprises the following steps: adding resveratrol or a derivative thereof into a first organic solvent (the weight percentage is 0.1-2%), and heating and dissolving at a first temperature of 80-100 DEG C to obtain a first solution; adding tocoxolam into the first solution, mixing (the weight percentage is 0.5-20%), and heating and dissolving at a second temperature (80-100 DEG C) to obtain a second solution; adding the second solution into the deionized water at a first rate (1mL / min to 3mL / min), and stirring and dispersing at a third temperature (50 DEG C to 70 DEG C); the nano-micelle is high in stability, excellent in transdermal absorption performance and good in anti-light aging effect, and has good skin whitening and anti-oxidation effects.

The invention provides a preparation method of fusidic acid emulsifiable paste, and relates to the field of pharmaceutical preparations, and the preparation method comprises the following steps: step 1, preparation of fusidic acid nanoparticles, step 2, preparation of an oil phase of the emulsifiable paste, step 3, preparation of a water phase of the emulsifiable paste, step 4, emulsification, and step 5, mixing. According to the fusidic acid nanoparticles, firstly, a composite carrier is prepared, then fusidic acid, PLGA, the composite carrier and absolute ethyl alcohol are mixed, a nanoparticle oil phase is obtained, then PVA, PVP, sodium dodecyl glucoside sulfonate and dipotassium ethylenediaminetetraacetate are mixed with deionized water, a nanoparticle water phase is obtained, and finally a nanoparticle suspension is obtained through mixing. The fusidic acid emulsifiable paste prepared by the method can effectively solve the problems that the traditional emulsifiable paste bulk drugs are easy to agglomerate, the drug molecule particle size is large and the like, and the transdermal absorption rate and bioavailability of fusidic acid are improved, so that the antibacterial effect is enhanced.

The invention relates to a multi-mode precisely-regulated pelvic fumigation therapeutic apparatus and a using method thereof, and belongs to the technical field of pelvic fumigation therapies.The multi-mode precisely-regulated pelvic fumigation therapeutic apparatus comprises a therapeutic apparatus base, an antibacterial silica gel cushion, a multi-mode mist generating system, a control host, a handheld control terminal, a sewage collecting box and a storage battery; the therapeutic apparatus base is provided with a fumigation hopper. According to the invention, a sectional PID heating pipe is adopted to replace a traditional constant-temperature heating rod, and the stability of the mist temperature can be ensured by combining a temperature and pressure sensor, so that the scalding risk caused by temperature fluctuation of traditional equipment is solved, and an ultrasonic nano atomization technology is adopted, and the particle size is lt; compared with the prior art, the device has the advantages that the structure is simple, the size is small, the diameter is small, the diameter is 100 nm, the medicine transdermal absorption rate is increased to 82% from 42% of a traditional boiling method, the better treatment effect is achieved, the Venturi effect supercharging device is arranged to achieve the effect that the steam pressure is adjustable in the range of 0.05-0.3 MPa, the steering engine is arranged to adjust the spraying angle of the annular laying nozzle, and therefore the mist action range can be adjusted according to needs.

The invention relates to the technical field of cosmetics, in particular to a preparation method and application of a supramolecular solvent containing puerarin. The supramolecular solvent containing puerarin comprises puerarin, a hydrogen bond donor and a hydrogen bond receptor, the molar ratio of the hydrogen bond donor to the acceptor is (1-3): (1-2). The puerarin-containing supramolecular solvent formed by using weak interaction force such as hydrogen bonds can effectively solve the problems that puerarin is easy to separate out in the product and poor in transdermal absorption and the like, and meanwhile, the puerarin-containing supramolecular solvent can synergistically promote the effect of puerarin in the oil-control acne-removal product. Cosmetics prepared by adopting the supramolecular solvent prepared by the invention have good oil control and soothing effects, and the preparation process is simple, large-scale production is easy, and the properties are stable.

The invention discloses a handheld ultrasonic beauty instrument, and relates to the technical field of beauty instruments, the handheld ultrasonic beauty instrument comprises a handle, a connecting shell is fixed at one end of the handle, a probe is fixed at the open end of the connecting shell, an ultrasonic generator a is fixedly mounted in the probe, the handheld ultrasonic beauty instrument further comprises an atomization mechanism, and the atomization mechanism comprises a storage cylinder fixed in the handle; a partition plate is fixed in the storage cylinder, a micro pump is fixedly installed in the handle, and a proportional valve is arranged between the micro pump and the storage cylinder. Through a proportioning system constructed by the micro pump and the proportional valve, the concentration of the cosmetic liquid can be dynamically adjusted in real time in the operation process of the ultrasonic cosmetic instrument, and based on the instant skin type requirement and scene change of a user, the user can conveniently use the ultrasonic cosmetic instrument. The mixing ratio of the concentrated cosmetic liquid to the solvent is accurately controlled, so that the high-activity component acts on the skin at the optimal concentration, and on the basis, the proportioned cosmetic liquid can be converted into nano-scale fog drops through the ultrasonic generator b, so that the transdermal absorption rate is remarkably improved, and the cosmetic effect is further enhanced.

The invention provides an enhanced transdermal absorption beauty patch containing efficient active polydeoxyribonucleotide PDRN (DNA sodium) and a low-temperature preparation method thereof.The beauty patch sequentially comprises an outer stripping backing layer, a slow release core layer, a quick release core layer and a soluble hollow microneedle array layer from outside to inside, and the outer stripping backing layer is a PET / aluminum foil / polyethylene composite film; the mass ratio of the three components is (80-90): (0.5-2): (0.1-0.5). Efficient transdermal delivery, long-acting effect, high-activity retention and excellent biocompatibility of the PDRN are realized, and the transdermal efficiency and the use safety of the beauty patch are remarkably improved.

The invention discloses a plant extract transdermal absorption dynamic regulation and control method based on artificial intelligence. The method comprises the following steps: S1, forming a structured data sequence; s2, generating preliminary prediction data; s3, forming an optimized GRU prediction model; s4, performing real-time prediction on a future transdermal absorption state by utilizing the optimized GRU prediction model, and generating prediction data of an absorption rate, a drug concentration in skin and an accumulated absorption amount; and S5, according to the prediction data and a preset drug release target, carrying out global search and optimization on drug release control parameters through the firefly population optimization algorithm, generating a corresponding dynamic regulation and control instruction, and adjusting the release rate and carrier diffusion characteristics of a drug release device. The release rhythm can be actively adjusted according to the predicted data, so that the concentration stability and the curative effect persistence of the plant active ingredients in the target cortex are ensured.

This invention discloses a recombinant collagen liposome, its preparation method, and its application. The recombinant collagen liposome comprises 1-10 parts recombinant type XVII collagen, 2-15 parts soybean lecithin, 0.3-2 parts tocopherol, 0.5-7 parts antioxidant, 20-54 parts glycerol, and Dendrobium officinale enzymatic hydrolysate to a total weight of 100 parts. This invention improves the stability and transdermal absorption of recombinant type XVII collagen by encapsulating it in liposomes. The prepared recombinant collagen liposomes not only have a high encapsulation efficiency but also retain excellent barrier repair and anti-wrinkle effects after 8 weeks of storage, making them suitable for use in cosmetics.