517 results about "Transdermal absorption" patented technology

The invention relates to the technical field of cosmetics, and discloses an anti-inflammatory soothing cosmetic composition which comprises the following components in percentage by weight: 0.5%-4% of a barrier repairing component, 0.5%-3% of an immunoregulation component, 0.3%-2.5% of a nerve soothing component, 0.3%-3% of an anti-inflammatory plant compound, 1%-10% of a moisturizing soothing enhancer and the balance of auxiliary materials. According to the components, through a five-dimensional synergistic mechanism of barrier repair, immune tolerance, nerve desensitization, anti-inflammatory itching relieving, moisturizing and stability maintaining, anti-inflammatory relieving and barrier repair are remarkably enhanced; ceramide, rare ginsenoside, phytosterol ester and free fatty acid are introduced to synergistically construct a bionic liposome which is closer to the composition of human cuticle lipid, so that the transdermal absorption and stability are enhanced, and the repair efficiency is remarkably improved; the dipotassium glycyrrhizinate, the tamarix chinensis flower extract, the purslane extract, the dinoflaxanthine and the baicalin cooperate to quickly resist inflammation and relieve itching and strengthen barrier repair, so that the composition is suitable for highly sensitive skin.

The invention discloses an anti-aging face cream suitable for sensitive skin and a preparation method of the anti-aging face cream. The anti-aging face cream comprises 1-10 wt% of a supramolecular eutectic compound, 10-30 wt% of an auxiliary material and the balance of deionized water, the supramolecular eutectic compound comprises an anti-aging component, a supramolecular eutectic agent and Neosol-Aqulio, wherein the supramolecular eutectic agent is used for forming a supramolecular eutectic with the anti-aging component, and the Neosol-Aqulio is dispersed in the supramolecular eutectic; wherein the anti-aging component comprises oleuropein and hydroxytyrosol, and the supramolecular eutectic agent is nicotinamide, or a mixture of capryloyl glycine and betaine. Neosol-Aqulio, a supramolecular eutectic agent and an anti-aging component are utilized to form a supramolecular eutectic, so that active component delivery is facilitated, efficient transdermal absorption is realized, permeability, stability and mildness of the anti-aging active component are improved, the problem of sensitive skin cuticle permeation is solved, irritation of a traditional penetration enhancer is avoided, and the penetration enhancer is suitable for clinical application. The double effects of efficient permeation and mild anti-aging are realized.

This invention provides an anti-aging and repairing composition containing collagen and its preparation method, belonging to the technical field of medical, dental, or cosmetic products. Its components consist of hydrolyzed collagen, recombinant type III human collagen, artichoke leaf extract, and fermented blueberry seed oil. This invention uses recombinant type III human collagen and hydrolyzed collagen as its core, overcoming the limitations of traditional collagen through biotechnology, and supplementing it with double-fermented plant ingredients to solve the bottlenecks of transdermal absorption and anti-oxidation. The overall design conforms to the anti-aging triangle logic of "repair, defense, and moisturizing," and has good market prospects.

The invention belongs to the technical field of cosmetics, and particularly relates to a skin-color-uniformizing whitening composition derived from plant extracts and application of the skin-color-uniformizing whitening composition. The whitening composition provided by the invention is prepared from the following components in parts by weight: 10 to 15 parts of saussurea involucrata extract, 1 to 8 parts of dendrobium officinale extract, 1 to 5 parts of wood apple extract and 0.5 to 5 parts of banana fruit extract. The four plant extracts are synergistically compounded, transdermal absorption of active ingredients can be promoted, the tyrosinase inhibition rate is effectively increased, and the skin glossiness and whiteness are improved, so that the effects of whitening, brightening and uniformizing the skin color are achieved, the whitening composition is mild and non-irritant, the preparation method is simple and convenient to operate, and the whitening composition has large-scale production capacity and industrial feasibility. When the whitening composition is applied to skin care products such as face cream, the whitening and brightening effects of the face cream can be effectively improved, and the whitening composition has wide market application value.

The invention relates to the technical field of pharmaceutical preparations, and provides a minoxidil film coating agent as well as a preparation method and application thereof. The minoxidil film coating agent provided by the invention comprises 40-60% of propylene glycol, 3-7% of polyvinyl alcohol, 20-30% of ethanol, 1-7% of minoxidil and the balance of water. According to the invention, propylene glycol is taken as a solvent, a plasticizer and a transdermal absorption enhancer, polyvinyl alcohol is taken as a film-forming material, and ethanol is taken as a volatile agent, after administration, ethanol is volatilized to promote film formation of polyvinyl alcohol, and propylene glycol enhances the plasticity of the formed film, so that the effect of reducing liquid medicine loss is achieved, the local medicine concentration is increased, and the bioavailability is improved. The minoxidil liniment disclosed by the invention has excellent skin permeability, can effectively convey a medicine to a required part, and can ensure that the medicine is released at a fixed position of the skin and is accurately administered in a medicine release process, so that the stimulation of liquid medicine flow to other parts is reduced, and a good treatment effect is achieved.

The invention discloses a lipophilic liposome containing polydeoxyribonucleotide as well as a preparation method and application of the lipophilic liposome. The lipophilic liposome comprises the following components in parts by weight: 0.001-3 parts of polydeoxyribonucleotide; 0.5 to 3 parts of phospholipid; 0.1-2 parts of a cationic emulsifier; 0.1-3 parts of an anionic emulsifier; 40 to 70 parts of polyol; the total amount is 100 parts. According to the invention, an emulsifier system formed by combining lecithin with anionic and cationic compound surfactants is adopted, so that the transdermal absorption of PDRN is facilitated. The lipophilic liposome containing polydeoxyribonucleotide prepared by the invention can effectively resist nuclease degradation, prolong the acting time of PDRN in skin, and improve the skin anti-aging and repairing effects of the liposome. The anti-aging effect of the active ingredients is improved, and the bioavailability of the active ingredients is improved. The cosmetic composition can be widely applied to cosmetic formulas of various dosage forms.

The invention provides liquiritin gel as well as a preparation method and application thereof. The liquiritin gel is prepared from the following components in concentration: 0.1 weight percent to 2 weight percent of liquiritin, 0.1 weight percent to 4 weight percent of carbomer, 0.1 weight percent to 4 weight percent of water-soluble cellulose ether compounds and 1 to 10 mL / Kg of triethanolamine. Wherein liquiritin and the water-soluble cellulose ether compound are respectively used as a main thickening agent and an auxiliary thickening agent, a synergistic thickening system is more stable and more suitable for liquiritin compared with a single thickening system or other neutralization systems, and the liquiritin and the water-soluble cellulose ether compound can synergistically adjust viscosity; triethanolamine is used as a neutralizer to neutralize carboxyl of carbomer to form gel; carbomer and a water-soluble cellulose ether compound are cooperated according to a specific ratio and can be different from a single thickening system or different neutralization systems, so that the liquiritin gel with excellent film-forming property, proper flowability and high transdermal absorption efficiency is prepared.

The invention provides moisturizing and anti-wrinkle cream and a preparation method thereof. The moisturizing and anti-wrinkle cream is prepared from the following raw materials in percentage by mass: 2%-10% of fibroin composite microsphere solution, 2%-5% of skin conditioner, 1%-2% of emollient, 8%-15% of humectant, 0.1%-1% of emulsifier, 1%-2% of emulsion stabilizer, 0.1%-0.2% of thickener and the balance of water. Wherein the fibroin composite microsphere is a spherical aggregate obtained by interpenetrating and entangling fibroin and poly-desoxyribonucleic acid in a cation environment and folding and compressing the fibroin and the poly-desoxyribonucleic acid; the composite microspheres can be percutaneously absorbed, and when the composite microspheres are applied to a formula of cream, the percutaneous permeation efficiency of the cream is greatly improved, and the moisturizing and anti-wrinkle effects of the cream are improved.

The invention relates to the technical field of cosmetics and transdermal drug delivery, in particular to a resveratrol-tocoxolam nano-micelle and application of the resveratrol-tocoxolam nano-micelle in preparation of antioxidant and skin whitening products. The preparation method comprises the following steps: adding resveratrol or a derivative thereof into a first organic solvent (the weight percentage is 0.1-2%), and heating and dissolving at a first temperature of 80-100 DEG C to obtain a first solution; adding tocoxolam into the first solution, mixing (the weight percentage is 0.5-20%), and heating and dissolving at a second temperature (80-100 DEG C) to obtain a second solution; adding the second solution into the deionized water at a first rate (1mL / min to 3mL / min), and stirring and dispersing at a third temperature (50 DEG C to 70 DEG C); the nano-micelle is high in stability, excellent in transdermal absorption performance and good in anti-light aging effect, and has good skin whitening and anti-oxidation effects.

The invention provides an enhanced transdermal absorption beauty patch containing efficient active polydeoxyribonucleotide PDRN (DNA sodium) and a low-temperature preparation method thereof.The beauty patch sequentially comprises an outer stripping backing layer, a slow release core layer, a quick release core layer and a soluble hollow microneedle array layer from outside to inside, and the outer stripping backing layer is a PET / aluminum foil / polyethylene composite film; the mass ratio of the three components is (80-90): (0.5-2): (0.1-0.5). Efficient transdermal delivery, long-acting effect, high-activity retention and excellent biocompatibility of the PDRN are realized, and the transdermal efficiency and the use safety of the beauty patch are remarkably improved.

This invention discloses a recombinant collagen liposome, its preparation method, and its application. The recombinant collagen liposome comprises 1-10 parts recombinant type XVII collagen, 2-15 parts soybean lecithin, 0.3-2 parts tocopherol, 0.5-7 parts antioxidant, 20-54 parts glycerol, and Dendrobium officinale enzymatic hydrolysate to a total weight of 100 parts. This invention improves the stability and transdermal absorption of recombinant type XVII collagen by encapsulating it in liposomes. The prepared recombinant collagen liposomes not only have a high encapsulation efficiency but also retain excellent barrier repair and anti-wrinkle effects after 8 weeks of storage, making them suitable for use in cosmetics.

The invention relates to nano-scale reverse micelle oil capable of promoting permeation, realizing targeted delivery and enhancing vitriol and a preparation method of the nano-scale reverse micelle oil. The nano-scale reverse micelle oil comprises a boro, a nonionic surfactant, short-chain alcohol, long-chain alcohol and grease. The preparation method comprises the following steps: mixing and stirring the glassine, the short-chain alcohol and the long-chain alcohol, then adding the nonionic surfactant, continuously stirring, and finally adding the grease and stirring to obtain the nano-scale reverse micelle oil. The nanoscale reverse micelle oil is clear and transparent in appearance, the average particle size is smaller than 300 nm, and the nanoscale reverse micelle oil has good stability; a good permeation promoting effect is achieved, and the transdermal absorption amount of the glassine can be greatly improved. The bose oil can be added into a pure oil system, and the application field of bose oil is expanded.

The invention relates to a poly (deoxyribonucleotide) self-assembled supramolecular nanoparticle composition, a preparation method and application thereof and cosmetics, the poly (deoxyribonucleotide) self-assembled supramolecular nanoparticle composition comprises PDRN and mussel protein, and the mass ratio of the PDRN to the mussel protein is 1: (0.05-10). The PDRN-mussel protein self-assembled supramolecular nano-particles have the beneficial effects that the PDRN-mussel protein self-assembled supramolecular nano-particles are prepared by utilizing the inherent charge properties of PDRN and mussel protein, so that the microscopic sizes of the PDRN and mussel protein are compressed, the transdermal absorption of the PDRN and mussel protein is greatly improved by utilizing the properties of the nano-particles, and a synergistic repairing effect is shown.

The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic delivery system based on a natural wall material, a preparation method and application. The cosmetic delivery system is of a core-shell structure, a core is a cosmetic active component, and a shell layer is a composite polymer gel network of sodium alginate, sophorolipid and cellulose. The natural polysaccharide composite wall material is green and safe, has good biocompatibility and strong compatibility with cosmetic formulas, and does not irritate the skin. The delivery system can effectively protect cosmetic active ingredients from being damaged by illumination and oxygen, and the storage stability of the active ingredients is remarkably improved; meanwhile, slow release and targeted transdermal absorption of active ingredients are realized, and the bioavailability is improved.

The invention relates to the field of polymer composite materials, and discloses a bionic polymeric gel and a preparation method and application thereof, the gel comprises a hydrophobic continuous phase skeleton composed of siloxane, a styrene block copolymer and the like, and a hydrophilic network formed by in-situ polymerization of hydrophilic precursors such as super absorbent resin and the like and interpenetrating with the hydrophobic continuous phase skeleton. The preparation method adopts a continuous reaction extrusion process and comprises the following steps: firstly, melting and blending the main components, and then sequentially injecting the bifunctional interface anchoring agent, the skeleton protection type comonomer and the thermal initiator through a lateral charging port. According to the method, a chemical bond is constructed on a two-phase interface through an interface anchoring agent, and degradation of a hydrophobic skeleton is inhibited by using a skeleton protection type comonomer. The prepared gel is stable in structure, has excellent adhesion and high hygroscopicity, and can be used for preparing medical application, pressure-sensitive adhesive or transdermal absorption preparations.

The invention relates to the technical field of exosomes, and particularly discloses a cosmetic anti-aging mesenchymal stem cell exosome composition, which comprises a therapeutically effective amount of mesenchymal stem cell-derived exosome, the functional carrier comprises a transdermal absorption enhancer and an antioxidant stabilizer; at least one synergistic active component selected from the group consisting of small molecule peptides, plant-derived antioxidants, hyaluronic acid or derivatives thereof; the small molecule peptide is one of oligopeptide-1 and palmitoyl tripeptide-5; the plant source antioxidant is one of resveratrol and ferulic acid; wherein the exosome and the synergistic active component are compounded through a phospholipid bilayer fusion technology; through a phospholipid bilayer fusion technology, the mesenchymal stem cell exosome and a synergistic active component are directionally compounded, an exosome membrane structure is used as a natural carrier, the active component is effectively prevented from being degraded, and meanwhile, the bioavailability is improved by utilizing the targeting property of the exosome membrane structure.

The invention belongs to the technical field of cosmetics, and particularly relates to a lifting-assisted full-effect mask with efficient transdermal absorption and a preparation method thereof.The mask comprises carrier membrane cloth and composite essence which are designed in a partitioned mode, and the carrier membrane cloth assists the physical lifting action through eye tail lifting belts, a lower jaw tightening area and a cheekbone supporting area which are of the specific size; the compound essence takes the sheep embryo extract as a core, and is compounded with a transdermal promotion system, a moisturizing composition and multiple functional components, so that efficient transdermal absorption and total-effect synergy are realized. The product has the effects of resisting wrinkles, tightening, moisturizing, soothing and resisting oxidation, and is mild and non-irritant. The preparation method comprises the steps of laser cutting and sterilization of carrier membrane cloth, split-phase emulsification of composite essence, low-temperature addition of active ingredients and the like, and the process is simple and stable and suitable for industrial production.

The application provides an enhanced transdermal absorption cosmetic patch containing high-efficiency active polydeoxyribonucleotide PDRN (DNA sodium) and a low-temperature preparation method thereof. The cosmetic patch comprises, from outside to inside, an outer release backing layer, a slow-release core layer, a quick-release core layer and a soluble hollow microneedle array layer. The outer release backing layer is a PET / aluminum foil / polyethylene composite film, and the mass ratio of the three is (80-90):(0.5-2):(0.1-0.5). The PDRN is efficiently delivered transdermally, has long-term effect, high activity retention and excellent biocompatibility, and significantly improves the transdermal efficiency and use safety of the cosmetic patch.

The invention belongs to the technical field of cosmetics, particularly discloses moisturizing nano-liposome emulsion prepared by a microjet method and a preparation method of the moisturizing nano-liposome emulsion, and aims to solve the problems of poor stability of active ingredients, low transdermal absorption efficiency, single effect and non-uniform particle size in a liposome preparation process in the existing moisturizing cosmetics. The nano-liposome emulsion is prepared from glycosylglycerol, acetylchitosamine, tremella polysaccharide, a myrothamnus flabellifolia leaf / stem extract, an artemisia annua extract, a lactobacillus fermentation product, flat nuclear wood oil, hydrogenated lecithin and phosphatidylcholine. The emulsion has excellent moisturizing, soothing and repairing effects, can be used for preparing skin care products such as water aqua, emulsion and cream, and has the advantages of high utilization rate of active ingredients and good stability.

The invention discloses a recombinant collagen composite nano-liposome as well as a preparation method and application thereof. The composite nano-liposome provided by the invention comprises a liposome which is provided with a closed lipid bilayer molecular layer and a content encapsulated in the closed lipid bilayer molecular layer; and a polyquaternium-51 layer that encapsulates the liposome. A supramolecular assembly, phospholipid wrapping and polyquaternium-51 protective layer is formed on the surface of the protein through a hierarchical wrapping technology, and multiple technologies are superposed, so that the stability and the transdermal absorption effect of the protein and the lipidosome are remarkably improved.

The invention relates to preparation and application of a desoxyribonucleic acid and desoxyribonucleic acid derivative transdermal delivery system, and belongs to the technical field of biological medicine and skin care products. Desoxyribonucleic acid and derivatives thereof have the effects of resisting aging, repairing and the like, but are difficult to penetrate through a skin barrier due to large molecular weight and strong polarity. According to the invention, hydroxyethyl chitosan, desoxyribonucleic acid and derivatives thereof are combined through electrostatic interaction to form the nano-composite. The compound is small in particle size and can promote transdermal absorption through hair follicle or cuticle gaps. The preparation method is simple, does not need an auxiliary reagent, and comprises the step of mixing a hydroxyethyl chitosan solution and a deoxyribonucleic acid derivative solution. Experiments show that the compound significantly enhances the transdermal efficiency, and has the effects of promoting cell repair and proliferation and resisting inflammation. The composition can be used for skin care products, and is high in safety and wide in application prospect.

The invention relates to a whitening and anti-aging composition which is characterized by comprising a solvent, a vitamin C derivative and an active agent, and the vitamin C derivative comprises 3-o-ethyl ascorbic acid, ascorbyl glucoside, magnesium ascorbyl phosphate, sodium ascorbyl phosphate and ascorbic acid polypeptide. By the adoption of the technical scheme, the whitening and anti-aging composition and the cosmetic containing the composition are high in stability, good in transdermal absorbability, lasting in effect, mild and capable of whitening skin and resisting aging in a synergistic mode.

The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a traditional Chinese medicine essential oil microencapsulation transdermal absorption process. The core of the process is that a transdermal enhancer, traditional Chinese medicine essential oil and a wall material are synchronously added in an emulsification stage, a uniform emulsion system is formed through emulsification treatment, then curing treatment is performed to enable the wall material to be crosslinked to form microcapsules, and the microcapsules are separated, dried and dispersed in a matrix to prepare the transdermal preparation. According to the method, full integration of a transdermal enhancer and a microcapsule structure is realized, transdermal permeation of essential oil components is effectively promoted, meanwhile, the stability and biological activity of the essential oil are kept, and the clinical application value of the traditional Chinese medicine essential oil is improved.

The application discloses a preparation method of arbutin analogues with high transdermal absorption efficiency, and is characterized in that the method comprises the following steps: under the action of a solvent and a catalyst, compound I and compound II are subjected to esterification to obtain compound III, wherein the compound III is the arbutin analogue. The arbutin (compound I) is used as a raw material, the structure of the arbutin is modified through esterification, the transdermal performance of the arbutin is improved, the bioavailability is increased, and finally the whitening effect is improved.

The invention relates to the technical field of skin care essence, in particular to double-layer essence with an anti-aging effect and a preparation method thereof.The double-layer essence with the anti-aging effect is composed of a water phase layer and an oil phase layer; the water-phase layer is prepared from the following raw materials in percentage by mass: 3-8% of hydroxypropyl tetrahydropyrantriol, 0.1-0.5% of tetrahydromethylpyrimidine carboxylic acid, 0.01-0.1% of a pepper kava extract, 1-5% of lactobacillus / soybean milk fermentation product filtrate, 1-5% of vitamin C ethyl ether, 1-5% of acetylchitosamine, 3-8% of 1, 3-butanediol and the balance of water. The invention relates to an anti-aging mask which comprises the following components in percentage by weight: 1-10% of 1, 3-butanediol, 0.01-0.1% of sodium hyaluronate, 0.1-0.5% of a buffer system, 5-10% of glycerol and the balance of deionized The oil phase layer is prepared from the following raw materials: 0.5-2% of ascorbyl tetraisopalmitate, 11-44% of compound plant-derived grease and 0.05-0.3% of tocopheryl acetate, and the problems that existing essence oil is lack of a multi-dimensional synergistic anti-aging effect, and the stability and transdermal absorption efficiency of water-soluble active ingredients and oil-soluble ingredients are difficult to consider are solved.

The invention discloses a traditional Chinese medicine liniment for treating rheumatoid arthritis and a preparation process thereof, the traditional Chinese medicine liniment is composed of a wind-dispelling and pain-relieving liquid medicine and auxiliary materials, the wind-dispelling and pain-relieving liquid medicine contains eight traditional Chinese medicines of thorny elaeagnus root, erythrina bark, kadsura longepedunculata root, waxberry root, ardisia crenata, rose mallow root, glabrous sarcandra herb and wikstroemia canescens root, and is prepared by ultrasonic extraction; the auxiliary materials comprise polyvinyl alcohol, a chitosan-acetic acid solution, glycerol, azone, methylparaben, vanillyl butyl ether and ethanol. The liniment is short in film forming time and good in stability, has excellent transdermal absorption performance and antioxidant activity, can remarkably relieve joint swelling of RA model mice, improve the pain threshold value, improve joint pathological injuries, achieve local precise long-acting administration, reduce side effects of the whole body and improve patient compliance, is suitable for clinical treatment of RA, and has a wide application prospect. The problems that an existing rheumatoid arthritis treatment medicine is large in side effect, and a traditional Chinese medicine preparation is short in efficacy duration and inconvenient to use are solved.

This invention discloses a muscle-relaxing and meridian-clearing health powder and its preparation and application methods, belonging to the technical field of traditional Chinese medicine external health care products. The health powder is composed of fifteen raw medicinal materials: safflower, angelica, asarum, kudzu root, red peony root, scutellaria, dragon's blood, saposhnikovia root, frankincense, myrrh, cinnamon twig, mugwort leaf, coptis root, *Lycopodium clavatum*, and *Clematis armandii*. These materials are dried, pulverized to 80-120 mesh, and then evenly mixed. This invention, through a unique formulation design, integrates multiple effects such as promoting blood circulation and removing blood stasis, dispelling wind and cold, relieving muscle tension and clearing meridians, and clearing heat and drying dampness. Combined with a refined pulverization process, it significantly improves the dissolution rate and transdermal absorption efficiency of the drugs. During use, a hot compress applied via steam allows the medicinal properties to directly reach the affected area, effectively relieving pain and discomfort in the neck, shoulders, waist, legs, and joints. This invention's product has a scientific formulation, advanced technology, is convenient to use, and highly safe, possessing broad market application prospects.

The invention discloses a polygala tenuifolia aqueous extract as well as a preparation method and application thereof, and the preparation method comprises the following steps: (1) removing impurities from a polygala tenuifolia medicinal material, and crushing to obtain polygala tenuifolia coarse powder for later use; (2) putting the polygala tenuifolia coarse powder obtained in the step (1) and pure water into an extraction device according to a solid-liquid ratio of 1: (10-15) (g / mL), and extracting for 2-3 times while keeping a slight boiling state; (3) after each time of extraction in the step (2) is finished, filtering, and collecting filtrate of each time to obtain a polygala tenuifolia water extract; and (4) concentrating and drying the polygala tenuifolia water extract in the step (3) to obtain polygala tenuifolia water extract dry powder. The polygala tenuifolia aqueous extract is used as an effective component to prepare the external medicament for treating the red and swollen skin, so that the limitation of dosage forms such as original water decoction or medicine residue external application is broken through, the transdermal absorption and the curative effect are remarkably improved, the efficient local treatment of the skin abscess is realized, and the problems of systemic side effects and drug resistance of antibiotics caused by oral medicines are avoided; the applicable crowd is expanded.

This application relates to the field of veterinary drug technology, and discloses a transdermal absorption-enhancing ointment and its preparation process. The ointment components include white petrolatum, anhydrous lanolin, caprylic / capric triglycerides, hydrophobic fumed silica, and a highly fluid active permeation-enhancing phase. The permeation-enhancing phase contains active drugs and soybean lecithin, which self-assemble to form an inverse micelle aggregate. Soybean lecithin cross-links with the silanol groups on the surface of silica to form an intermolecular hydrogen bond network, constructing a sterically hindered framework within a continuous lipid matrix to prevent the polar drug-loaded phase from permeating and separating upon heating. Simultaneously, the inverse micelle structure effectively improves the transdermal absorption rate of the drug. The preparation process controls the lipid crystallization kinetics through slow cooling under negative pressure and micro-shear dynamic rheology. This invention solves the problems of easy precipitation upon heating, low transdermal efficiency, and poor rheological properties in traditional ointments, resulting in a product with a stable physical structure and good pseudoplastic texture.

The invention discloses a preparation method of dendrobium polysaccharides and cosmetic application of the dendrobium polysaccharides, and relates to the technical field of daily necessities. The preparation method of the dendrobium polysaccharide comprises the following steps: mixing dendrobium officinale powder with water to obtain a to-be-extracted solution; performing ultrasonic extraction on the to-be-extracted solution, adding a compound enzyme into the to-be-extracted solution for enzymolysis after ultrasonic extraction, and filtering the enzymatic hydrolysate by adopting an ultrafiltration membrane with the molecular weight cut-off of 5000-10000 Da after enzymolysis is finished. According to the method disclosed by the invention, the extraction effect of the dendrobium polysaccharides can be remarkably improved and the content of the dendrobium polysaccharides can be increased in a manner of ultrasonic extraction, enzymolysis and ultrafiltration membrane filtration, and the prepared dendrobium polysaccharides are relatively high in content and relatively small in molecular weight. The ultra-low molecular dendrobium polysaccharide (the molecular weight is generally less than 10kDa) is selected as a component of the anti-oxidation and anti-wrinkle composition, so that the transdermal absorption efficiency and bioavailability of the anti-oxidation and anti-wrinkle composition can be remarkably improved. The antioxidant and anti-wrinkle composition can be widely applied to preparation of skin care products or cosmetics.