1968 results about "Transdermal absorption" patented technology

A transdermal contraceptive delivery system (TCDS) for fertility control in women is described. It comprises a backing layer, an adjoining layer of a solid absorption adhesive polymer matrix in which effective daily doses of an estrogen and a progestin are dispersed and released for transdermal absorption. Presently preferred is the use of the synthetic estrogen, ethinyl estradiol, and the synthetic progestin, levonorgestrel. Along with these two steroidal contraceptive agents, a combination of several chemical skin permeation enhancing agents, including capric acid, blended at specific weight ratios, ranging from 2:1:1:0.8 to 6:1:1:0.8, are homogeneously dispersed in the adhesive polymer matrix. The invention also provides a method of fertility control utilizing the transdermal contraceptive delivery system.

It is intended to provide a transdermal absorption patch which is highly excellent in transdermal absorption properties and long-lasting drug effect even in the case where a drug-effect component contained in the transdermal absorption patch is a basic drug hardly soluble in a pressure-sensitive adhesive base, has a high stability of the drug contained therein with the passage of time and can achieve improvement in the compliance and simplification of the administration method. These problems can be solved by providing a transdermal absorption patch which contains a basic drug having an octanol/water partition coefficient (logarithm) in the free state of 3 or above, a pressure-sensitive adhesive base and a (meth)acrylic copolymer having carboxyl group.

Disclosed are multilayered liposomes for transdermal absorption and a method of preparing the liposomes. The multilayered liposomes are prepared using a mixture of oil-phase components comprising squalane, sterols, ceramides, neutral lipids or oils, fatty acids and lecithins, is 200 to 5000 nm in particle size, and is capable of entrapping a physiologically active substance. The multilayered liposomes entrap a larger amount of a physiologically active substance and are structurally stable when encapsulating the physiologically active substance, compared to unilamellar liposomes. Also, they are prepared by a simple and cost-effective process not using a high-pressure homogenizer but using a general homo mixer. Further, since the multilayered liposomes are prepared in a larger size than the intercellular spaces in the stratum corneum, they overcome the tension of surrounding cells when passing through the intercellular spaces and are thus able to penetrate into the dermal layer, compared to nano-sized unilamellar liposomes. Thus, the multilayered liposomes are useful for enhancing the transdermal absorption of physiologically active substances.

The present invention provides a substance which promotes the transdermal absorption of a pharmacologically active component while little irritating the skin. The present invention relates to a transdermal absorption promoter which comprises, as the active component, at least one member selected from among isopulegol, 2-(menthoxy)ethanol and 2-methyl-3-(menthoxy)propane-1,2-diol; and an external skin formulation which comprises a pharmacologically active component such as a psychotropic component, an anti-inflammatory component, an analgesic component, an antipyretic component, a whitening component or a hair growth-promoting component, together with the aforesaid transdermal absorption promoter.

The present invention has an object to provide an external dermatological formulation having satisfactory blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing effect, hair nourishing effect, emusifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and/or transdermal absorption-promoting effect with a satisfactory safety and skin feeling; The object is solved by providing an external dermatological formulation comprising a saccharide derivative of α,α-trehalose and one or more members selected from substances having any one of blood flow-promoting effect, antiinflammatory effect, antibacterial effect, moisturizing effect, whitening effect, UV-absorbing effect, UV-scattering effect, antioxidant effect, hair growing efect, hair nourishing effect, emulsifying effect, astringent effect, wrinkle-reducing effect, cell-activating effect and transdermal absorption-promoting effect.

The invention provides a sterile polymerized covering for a wound surface-medical wet dressing for a burn wound, a preparation method of the dressing, and application. The dressing comprises the following components: 10 to 30g of chitosan, 30 to 80g of polyving akohol, 5 to 10g of alginate, 5 to 15g of isomaltose hypgather, 2 to 6g of carbomer 940, 2 to 5g of gelatin, 5 to 10g of sodium carboxymethylcellulose, 10 to 30g of glycerol, and 0.01 to 0.2g of menthol; 15 to 60g of condensed tannin which is remarkable in treatment can be selectively added; and a skin penetration enhancer or an appearance conditioning agent also can be selectively added. The dressing can be prepared into an irregular dressing in order to be suitable for the wound surfaces in irregular and special positions and also can be prepared into a solid plate-shaped dressing which can be shorn at random. According to the sterile polymerized covering dressing for the wound surface, the freezing and thawing technology and the irradiating technology are combined and cross-linked to realize the preparation, and the defects of the prior art can be overcome. The dressing is high in biocompatibility, free from toxicity and sensitization and high in mechanical strength and comfort level, is out of adhering during the process of being replaced after being attached for a long time, and is a nonantigenic protective barrier which has the effect of resisting and inhibiting bacteria.

A needle array transdermal absorption sheet to be attached onto a skin for supplying a drug into the skin, includes: a plurality of needle portions each having a tapered shape, each of the needle portions including a needle having a conical or pyramidal shape and a body part which has a columnar shape and whose end surface is connected to a base of the needle; a sheet portion having a flat-plate shape; and a plurality of frustum portions each having a frustum shape, the frustum portions which are arranged on a surface of the sheet portion in a manner that perimeters of larger bases of adjacent frustum portions are in contact with each other on the surface of the sheet portion, and smaller bases of which are respectively connected to the body parts of the needle portions.

A coenzyme Q₁₀ and ceramide-containing preliposome, and pharmaceutical preparations and cosmetics containing the same. The preliposome can further comprise other lipid components. A granular and lyophilized solid-preparation is produced by lyophilization or spray drying. Then, the coenzyme Q₁₀-containing proliposome is obtained by adding water in the said solid-preparation and shaking. Transdermal absorption of coenzyme is improved together with the effect of coenzyme Q₁₀ in cosmetics and the stability of coenzyme Q₁₀ and liposome, which facilitate the formulation of cosmetics.

The invention discloses an externally used gel preparation containing human umbilical cord mesenchymal stem cell extract as well as a preparation method and an application of the externally used gel preparation. The externally used gel preparation contains the human umbilical cord mesenchymal stem cell extract and a gel solution, wherein the human umbilical cord mesenchymal stem cell extract is the extract obtained after starvation culture; the gel solution contains sodium alginate, a compound electrolyte injection, a humectant and a penetration enhancer, and a stable and homogeneous gelatinous substance is formed. The externally used gel preparation can be used for preparing drugs for treating skin ulcer, burns, scalds, eczema, trauma and other diseases.

The invention provides a transdermal absorption preparation containing oxybutynin, which comprises gels, ointment and cream and aims at reducing the adverse reaction rate of the oxybutynin and lightening the serious adverse reaction degree, wherein when the content of the oxybutynin in the transdermal absorption preparation is 0.1-30 percent by weight, the content of the oxybutynin in the transdermal absorption preparation is preferentially to be 8-12 percent by weight. The invention also discloses the requirements of the transdermal absorption preparation in the aspects of formula compatibility and proportioning, as well as a preparation method and medication application of the transdermal absorption preparation.

The invention discloses a method for preparing ultra-low molecular weight hyaluronic acid oligosaccharides and a salt thereof through combination of solid-liquid biphasic enzymolysis and ultrafiltration. The method comprises the following steps: degrading hyaluronic acid and a salt thereof by utilizing hyaluronidase produced by bacilli; preparing high-concentration hyaluronic acid enzymatic hydrolysate by adopting the method of combining a solid-liquid biphasic enzymolysis system and an ultrafiltration system, and then performing inactivating, activated carbon adsorption and impurity removal,filtering and spray-drying to obtain the ultra-low molecular weight hyaluronic acid oligosaccharides and the salt thereof with the molecular weight of less than or equal to 3 kDa. The product preparedby the method is high in stability, ultra-low in molecular weight, good in inflammation resistance and percutaneous absorptivity, high in purity, strong in oxidation resistance, does not have cytotoxicity, has the advantages of repairing skin cell damage and the like, and can be widely applied to the fields of cosmetics, food and medicines. According to the method, the process flow is easy to operate; conditions are mild; various alcohols are not used; the energy consumption is relatively low; the method does not have damage to a product structure, does not have environmental pollution, and is suitable for large-scale industrial production.

The invention relates to a transdermal absorbent containing Iguratimod, which comprises gellies, ointment, and cream, wherein the mass percentage content of the Iguratimod in the transdermal absorbent is between 0.1 and 10 percent, and preferably the mass percentage content of the Iguratimod in the transdermal absorbent is between 0.4 and 3 percent; and the invention also discloses requirements of the transdermal absorbent on the selections of matrix and a transdermal enhancer. Furthermore, the invention also provides a method for preparing the transdermal absorbent containing the Iguratimod and pharmaceutical application thereof.

A topical mixture that produces nitric oxide and a method for using the topical mixture to increase the vasodilation of a bloodstream via transdermal absorption of the nitric oxide. The nitric oxide can then affect subcutaneous tissues. The systemic vasodilation of a mammal may be increased via a topical application of an appropriate nitric oxide producing substance.

The invention relates to flexible nanoliposomes with charges for cosmetics and a preparation method thereof. The flexible nanoliposomes with the charges for the cosmetics comprise the following components in part by weight: 1-1000 parts of neutral phospholipid, 0.5-500 parts of phospholipid with the charges, 1-1000 parts of cholesterol, 0.5-500 parts of surface active agent, 0.1-20 parts of hyaluronic acid, 0.5-250 parts of cosmetic active ingredients and 100-8000 parts of freeze drying protective agent. The flexible nanoliposomes with the charges for the cosmetics can obviously improve the stabilities of the cosmetic active ingredients, promote the percutaneous absorption and the interaction efficiency of the active ingredients, and also improve the retention and action time of the active ingredients on the skin surface and the skin deep layer; and the flexible nanoliposomes with the charges for the powdery cosmetic active ingredients are also benefit to the use, transportation and storage. The preparation method of the flexible nanoliposomes with the charges can adopt a mechanized method, so the stability of the product technology and quality is good, and the repeatability is high.

The invention provides a method for preparing high-purity beta elemene from natural plants containing the beta elemene such as curcuma zedoary (earthnuts or tubers of the curcuma zedoary), cedronella (fresh leaves of the cedronella), yellowtop (roots, stems, leaves, flowers and seeds of the yellowtop) and so on, which can improve the production efficiency from starting materials to the high-purity beta elemene and reduce production cost. Compared with the prior art, the method is mainly different in that the roots, stems, leaves, flowers and seeds of the natural plants are taken as raw materials; oleum volatile of specific parts of the natural plants is obtained by methods for extracting different oleum volatiles, and is distilled by molecular distillation method to remove compositions with high boiling points and non-volatile compositions; impurity compositions are removed by the ethanol extraction method and silver nitrate complex extraction method; and finally the beta elemene with the content between 95.0 and 99.9 percent is obtained through reduced pressure distillation or rectification. The bulk pharmaceutical chemicals not only can be prepared into oral dosing preparation such as emulsion oral liquid, self-emulsifying/ self-microemulsifying capsules, soft capsules and so on, but also can be prepared into non-alimentary dosing preparation such as emulsion injection, liquid drugs injection, transdermal absorbent, lung sprays, suppository and so on. The method has the advantages of novel design, concise operating steps, mild operating conditions and improvement of the production efficiency of the beta elemene.

The invention discloses an anti-aging cosmetic composition containing lycopene. The cosmetic composition is prepared from an oil phase composed of one or more oily components and lycopene, a mixed emulsifier composed of one or more emulsifiers and water, wherein the ratio of the mass of lycopene to the total mass of the oily components is (0.1-5):1,000, an HLB value of the mixed emulsifier is a weighted mean value of HLB values of all the emulsifiers composing the mixed emulsifier, the value taking interval of the HLB value of the mixed emulsifier is 8-18, and the mass ratio of the oil phase to the mixed emulsifier is 1:(0.05-1). According to the anti-aging cosmetic composition, all the ingredients are matched according to a specific proportion, the free radical scavenging capacity of lycopene can be fully achieved, after lycopene is percutaneously absorbed, excessive accumulation of free radicals can be fundamentally inhibited, and an anti-oxidant system of the skin is enhanced, so that aging is delayed.

The present invention discloses a Rhizoma Corydalis Decumbentis total alkaloids extract, its preparation method, pharmaceutical composition containing same. The total alkaloids mainly comprise : macleyine, tetrahydropalmatine, bicucalline, palmatine hydrochloride, 'xiawuning' alkaloid, corydaline harmine, other alkaloid and extract. The preparation method is : using Rhizoma Corydalis Decumbentis as material, adding right amount of polar solvent for leaching, merging the leachate, carrying out large pore adsorption resin chromatography, eluting impurity with diluted acid and alkaline aqueous solution orderly, eluting using polar organic solvent, collecting elution liquor, eliminating impurity further by alumina column adsorption, Collecting after-column liquid, concentrating liquor to obtain the Rhizoma Corydalis Decumbentis total alkaloids extract. The present invention also discloses a pharmaceutical composition containing the total alkaloids extract and uses of the pharmaceutical composition in preparing tablet, capsule, soft capsule, suppository, granula, transdermal absorption agent, drop pills, oral disintegrating agent, slow release agent, freeze-drying powder injection etc.

The invention belongs to the technical field of administration equipment, and relates to a macromolecule solid micro needle and a batched preparing method thereof. The macromolecule solid micro needle is composed of a base and needle body arrays distributed on the base. The height of each needle body in each needle body array is 200-900 microns, the distance between needle points is 200-600 microns, and the diameter of the bottom of each needle body is 30-800 microns. The size of each needle body array is 5 mm*5 mm to 10 cm*10 cm. Compared with the prior art, the macromolecule solid micro needle solves the key problems that in the current beautifying nutrient substance and medicine transdermal releasing technology, due to the shielding function of the cuticle in the skin cuticular layer, the substance transdermal absorption is difficult, and a human body can feel painful and discomfortable. Thus, the macromolecule solid micro needle is good in durability and low in cost, the manufacturing technology of the macromolecule solid micro needle is simple, and the macromolecule solid micro needle is suitable for batched production.