6 results about "Intercellular space" patented technology

The invention belongs to the technical field of pharmaceutical preparations, and particularly discloses a colchicine external nano latex agent as well as a preparation method and application thereof.The colchicine external nano latex agent is prepared from the following raw materials in percentage by mass: 0.1%-1.2% of colchicine, 0.5%-25% of an oil phase matrix, 2%-20% of a surfactant, 2%-15% of a cosurfactant, 0%-15% of a transdermal absorption enhancer, 3%-3.5% of a gel matrix, 0%-0.5% of a pH regulator and the balance of water, totaling 100%. According to the colchicine external nano latex agent, the optimal prescription is obtained by applying a pseudo-ternary phase diagram and combining with D-optimal mix design, the particle size of the nano emulsion is stably controlled to be about 14 nm, and the small particle size means faster Brownian movement and stronger penetration of skin cuticle gaps or improvement of the infiltration capacity through appendages such as hair follicles, so that the colchicine external nano latex agent has a good application prospect. The skin penetration efficiency is higher than that of other prescriptions with larger particle sizes, and the nanoemulsion with small particle size hardly shows lag time.

This invention discloses a uniform, ultrafine polymer nanomicelle, its preparation method, and its applications. The polymer nanomicelle is first formed by modifying a material based on poly(lactic-co-liquid) with ligands containing double bonds to create a polymer containing unsaturated bonds. The polymer then encapsulates berberine (BBR) via a self-emulsification process, followed by UV cross-linking and pH adjustment. The polymer nanomicelle uses materials obtained from FDA-approved excipient PLGA through simple modification, and subsequently, drug-loaded nanomicelles with a particle size of less than 10 nm are prepared via self-emulsification. Due to their small particle size, the nanomicelles can be transported through the intercellular spaces of epithelial cells, effectively improving drug bioavailability. Combined use with the intestinal permeabilizer SNAC can further enhance the transintestinal absorption capacity of the nanoparticles. The polymer nanomicelles exhibit high uniformity, good stability, good safety and biocompatibility, and no toxic side effects, making them a promising candidate for treating type 2 diabetes.

This invention discloses a method for removing hair from animal skin suitable for food processing, belonging to the field of food processing technology. The method employs a two-stage process of "pretreatment + targeted hair removal." First, glycosidase pretreatment degrades the protein-polysaccharide complex in the intercellular spaces of the epidermal cells, clearing the permeation barrier without damaging subcutaneous fat. Then, charge adaptation technology is used, utilizing enzymatic hydrolysis to naturally lower the pH of the system. Initially, the enzyme molecules carry the same charge as the hair follicle permeation channels, enhancing permeation efficiency. Later, as the pH decreases, the charge of the enzyme molecules reverses, targeting and binding with the charge of the matrix surrounding the hair follicle, achieving hair removal. This method overcomes the limitation of two-sided permeation, achieving highly efficient one-sided permeation hair removal, avoiding the need for degreasing and preserving subcutaneous fat to the maximum extent. Furthermore, the process completely avoids the use of chemical additives that pose food safety risks or damage flavor. It offers high hair removal efficiency and minimal loss of skin collagen, providing a safe and efficient hair removal solution for animal skin food processing.

The invention provides a drought-enduring plant selection system based on osmotic regulation substance dynamic monitoring, and relates to the technical field of plant phenotype and molecular characterization detection, and the drought-enduring plant selection system comprises S1, a self-cleaning microfluidic sampling module which comprises a microneedle array and a programmable microvalve, the self-cleaning microfluidic sampling module can periodically and quantitatively extract trace samples from intercellular fluid or phloem fluid on the surface of a plant living tissue to be detected in a non-destructive mode, channel blockage is prevented through self-cleaning circulation, and the molecular imprinting sensitization microcavity spectrum sensing module is in fluid communication with the self-cleaning microfluidic sampling module. According to the drought-enduring plant selection system based on the dynamic monitoring of the osmotic regulating substance, a self-cleaning microfluidic sampling and molecular imprinting sensitization microcavity spectrum sensing module is integrated on the surface of a living tissue; the system can realize non-destructive sub-micron level continuous on-line quantitative monitoring on osmotic regulation substances such as proline, soluble sugar and betaine in a plant living body state, and outputs a concentration change curve in real time.

The invention relates to the technical field of oral liquid preparation, in particular to a plant exosome oral liquid preparation method and system based on powder-liquid separation. Performing the following operations on each oral liquid plant raw material in the oral liquid plant raw material set: performing plant exosome extraction operation on the oral liquid plant raw materials to obtain an initial solid phase extracting solution and an initial stable intercellular fluid, and respectively integrating the initial solid phase extracting solution and the initial stable intercellular fluid, the preparation method comprises the following steps: preparing a solid-phase extracting solution and a stable intercellular fluid, carrying out multi-stage centrifugal separation operation according to the solid-phase extracting solution and the stable intercellular fluid to obtain an upper-phase exosome concentrated solution, carrying out exosome nano reconstruction on the upper-phase exosome concentrated solution to obtain a drug-loaded exosome suspension, and preparing the plant exosome oral liquid. According to the method, the structural integrity and biological activity of the exosome can be protected while efficient solid-liquid separation is realized.

The invention relates to a whitening composition, modified glutathione and a preparation method thereof. The preparation method of the modified glutathione specifically comprises the following steps: 1) obtaining a liposome suspension, performing ultrasonic dispersion, mixing the liposome suspension with hyaluronidase and a cross-linking agent, and stirring to obtain a HAase-Lip suspension; and 2) mixing glutathione with the HAase-Lip suspension, carrying out a stirring reaction, and carrying out ultrasonic treatment to obtain the glutathione-Lip composite material. The phospholipid bilayer vesicle structure of Lip can form a physical barrier, so that the efficacy attenuation is greatly delayed. Meanwhile, a skin-like lipid structure of Lip can be fused with a cuticle lipid bilayer, the nanoscale particle size of Lip can be matched with the cuticle gap size, and Lip penetrates through the cuticle by means of the permeation mechanism of Lip; on the other hand, HAase has the capability of degrading hyaluronic acid on the surface layer of the skin, assists Lip and internal GSH to permeate into the deep layer of the epidermis, and reduces the damage of transdermal penetration to the skin barrier.