151 results about "Nano emulsion" patented technology

The invention discloses a self-emulsifying adjuvant of a vaccine and a preparation method of the self-emulsifying adjuvant, and relates to the technical field of vaccine adjuvants. The adjuvant comprises an oil phase, an emulsifier and a freeze-drying protective agent, the oil phase comprises squalene and tocopherol, the emulsifier comprises polysorbate and a polyoxyethylene-polyoxypropylene block copolymer, and the freeze-drying protective agent comprises sugar and sugar alcohol. The preparation method comprises the following steps: emulsifying an oil phase and a water phase to form a nano-emulsion, and then freeze-drying to obtain freeze-dried powder. The adjuvant has the advantages of small particle size, uniform distribution, high stability, rapid reconstruction and the like, and can effectively maintain active components and improve the immune effect of vaccines.

The invention provides a rare ginsenoside high-internal-phase Pickering emulsion microcapsule, a preparation method thereof and application of the rare ginsenoside high-internal-phase Pickering emulsion microcapsule in the aspects of uric acid reduction and kidney protection, and the preparation method comprises the following steps: (1) mixing a pectin aqueous solution and a tannic acid aqueous solution, adjusting the pH value, and stirring to obtain pectin-tannic acid composite sol, namely a water phase; (2) adding rare ginsenoside into the oil, and stirring to fully dissolve the rare ginsenoside to obtain an oil phase; (3) mixing the water phase and the oil phase, stirring, standing and carrying out ultrasonic treatment to obtain a crude emulsion; (4) emulsifying and homogenizing the crude emulsion to obtain crude emulsion; (5) carrying out high-pressure homogenization on the crude emulsion, so as to obtain a rare ginsenoside high-internal-phase Pickering emulsion; and (6) drying the rare ginsenoside high internal phase Pickering emulsion, so as to obtain the rare ginsenoside high internal phase Pickering emulsion microcapsule. The invention solves the problems of low safety, poor stability and low bioavailability of the traditional nano-emulsion, and belongs to the technical field of functional foods.

The present disclosure relates to nanoemulsions of 5-amino-[4-(4-chlorobenzoyl)-3,5-dichlorobenzyl]-1,2,3-triazole-4-carboxamide (carboxy-amido-triazole or CAI), methods of preparing thereof, and their use in the treatment of inflammatory optic neuropathies.

The present application relates to a kind of nanodroplet system based on interface crosslinking curcumin and its preparation method, by the crosslinking complexation between gallic acid ester, metal ion, curcumin to construct nanodroplet system.Gallic acid ester is polyphenol compound, contains a large number of phenolic hydroxyl in structure, has strong chelating metal ability, can be complexed with most of trivalent metal ions and divalent excessive metal ions, called metal phenolic network;Metal ions such as copper, iron and other metal ions form complex by electrostatic interaction with the beta diketone group in the structure of curcumin.Therefore, the nanodroplet system constructed by the present application can maintain the chemical stability and light stability of curcumin, and has wide prospect for improving the current food field curcumin low solubility, poor stability and other problems.

The subject matter of the present invention is a perfusion fluid in the form of an oil-in-water PFC nanoemulsion, methods of producing this perfusion fluid, and its use in particular for organ perfusion and as a blood substitute preparation.

The invention relates to a medium-chain triglyceride nano-composite emulsion and a preparation method thereof, and belongs to the technical field of nano-emulsions. The composite emulsion comprises medium chain triglyceride, glycerol, an emulsifying aid and deionized water, an ether esterification CNF is added as a stabilizer, and the composite emulsion is synthesized by a two-step method: firstly esterifying methacryloyl chloride and nano cellulose, then enabling the esterified methacryloyl chloride and nano cellulose to react with sulfhydrylated polyoxyethylene through thiol-ene click reaction initiated by ultraviolet light, and introducing a hydrophilic ether chain. According to the structure, the stabilizer can be firmly anchored on an oil drop interface, and aggregation is prevented through the steric hindrance effect. When the emulsion is prepared, the stabilizer is dispersed in the water phase, then the oil phase is added for preliminary emulsification, and finally high-pressure homogenization treatment is performed. The emulsion prepared by the method is fine and uniform in particle size, obviously improved in stability, not easy to layer at high temperature and under long-term storage, excellent in spreadability and refreshing in skin feeling, and suitable for high-end cosmetic carriers.

The application provides a nanoemulsion and a preparation method and application thereof. The total amount of raw materials for preparing the nanoemulsion is 100%, and the raw materials include the following components: 1-40% of a composite surfactant, 1-25% of an oil phase, 1-30% of a co-surfactant, and the balance of a water phase; wherein the mass of the composite surfactant is 100%, and the composite surfactant includes the following components: 5-25% of a biological surfactant, 35-65% of a fatty alcohol polyoxyethylene ether surfactant, 1-20% of dodecyl benzene sulfonic acid and / or sodium salt thereof, 1-20% of oleic acid, and 1-5% of citric acid; the biological surfactant includes one or more than two combinations of sophorolipid, rhamnolipid, trehalose lipid, surfactin, alkyl polyglycoside, phosphatidylcholine, amino acid lipid, saponin, phospholipid, or derivatives thereof; and the average particle size of the emulsion droplets in the nanoemulsion is 1.5-5 nm. The nanoemulsion has excellent recovery performance.

The application discloses a preparation method of a self-emulsifying type wet spinning raw silk oil agent and a preparation method of high-uniformity carbon fibers, and belongs to the technical field of carbon fibers. In the application, polyglycerol and epsilon-caprolactone are catalytically prepared into PG-PCL; then the PG-PCL is reacted with acrylate to obtain acrylated PG-PCL; finally, the PG-PCL, the acrylated PG-PCL and perfluoropolyether acrylate are uniformly dissolved in acetone; then carboxylated cellulose nanocrystals and iron phthalocyanine are added and high-speed shearing emulsification is carried out, and water is gradually added to form a nanoemulsion; and the high-uniformity carbon fibers are obtained by combining a low-temperature preparation method of the carbon fibers. The method synchronously solves the problems of emulsion stability, fiber uniformity and carbonization compatibility, shortens a production cycle, is suitable for high-end fields such as aerospace and new energy vehicles, and has the advantages of high performance and green manufacturing.

The application relates to a preparation method of natural cyclic lipopeptide nano-encapsulates with high oil content, and the steps are as follows: natural emulsifiers, glycerol, oil and water are weighed, the natural emulsifiers comprise sodium subtilipetrol and polyglycerol-10 oleate; the natural emulsifiers and the glycerol are mixed and heated and stirred, the oil is added after being dissolved, and a gel phase is obtained; water is added to the gel phase until the gel phase is completely dispersed, and natural cyclic lipopeptide nano-encapsulates are obtained. The compounding and synergistic effect of the sodium subtilipetrol and the polyglycerol-10 oleate is used in the application, compared with two single emulsifiers, the oil loading content is improved and the particle size is reduced. The natural nano-emulsion with high oil content prepared by the application has the advantages of low emulsifier dosage, simple process, small particle size (less than 600 nm), high oil content (more than 20%) of the prepared nano-emulsion, strong stability, high active substance loading content, good penetration effect and the like, is suitable for most liquid oils, and has high application value in the field of cosmetics.

A method of preparing a flavoring composition and composition thereof for imparting citrus juice flavor, taste, and aroma to food stuffs comprising a nano emulsion comprising a mixture of acids, emulsifiers, essential oils, weighting agents, and a thickening and texturizing agent wherein the composition comprises essential oils at 100 to 200 parts per million (ppm); flavor compound mix (selected from a group of recipes) at 50 to 100 ppm, pectin at 0.5 to 1.0 % by weight or 5,000 to 10,000 ppm among other ingredients specific to the type of citrus fruit to be imparted.

Aspects of the disclosure provide a formulation for treating advanced pancreatic cancer, comprising a combination of a cannabinoid, a terpene, and a flavonoid. To enhance bioavailability and targeted delivery, the formulation is incorporated into a nanoplatform, such as a nanoemulsion, optimizing absorption and delivery to cancer cells. The nanoparticle-based composition specifically targets advanced stages of pancreatic cancer, aiming to inhibit tumor progression and improve clinical outcomes.

The invention discloses a surface-treatment-free water-based acrylate adhesive for a PVC (polyvinyl chloride) floor and a preparation method of the surface-treatment-free water-based acrylate adhesive, and belongs to the technical field of polymer adhesives. The adhesive comprises the following raw material components: 0.5-15% of ester-soluble chlorinated polypropylene and 26-32% of chlorine; 0.5-15% of acrylic acid; 1-5% of ethyl acrylate; 65 to 95% of butyl acrylate; 0.5 to 3 percent of nano ZnO emulsion; 0.5 to 2% of an aziridine cross-linking agent; 1-5% of a nonionic surfactant; 0.1-1% of a water-soluble initiator; wherein the ester-soluble chlorinated polypropylene is introduced by being dissolved in a mixed monomer of ethyl acrylate and butyl acrylate in advance. The obtained adhesive is good in stability and high in initial adhesion, surface treatment-free adhesion is realized, and the initial adhesion and cohesion are balanced; meanwhile, the coating has excellent heat resistance and creep resistance, is a full-water-based system, is extremely low in VOC content, is green and environment-friendly, and has important industrial application value.

This invention is related to the fields of medical biotechnology, nanobiotechnology, and nanomedicine. It involves a nanomedicine product that can release HOC1 (hypochlorous acid) at the tumor site in a controlled manner to treat lung cancer. HOC1 is a potent antimicrobial and antitumor agent that can target tumor tissues while minimizing damage to healthy tissues. The produced nanoparticles have a two-layer structure: the inner layer contains alginate, PFP (perfluoropentane), and Ca(OCl)2 to release HOC1, and the outer layer has a chitosan coating with folate and salicylic acid for targeting and proton release. The production process involves nanoemulsion and coating with the ionic gelation technique. When the nanoparticles are delivered to the lungs and targeted to cancer cells with folate, ultrasound radiation triggers the release of HOC1 to induce apoptosis and destroy cancer cells effectively, reducing side effects and improving treatment outcomes for lung cancer patients.

The application belongs to the technical field of bio-based packaging materials, and particularly relates to a novel double-layer composite film and application thereof. The novel double-layer composite film comprises the following steps: reacting palmitic anhydride and carboxymethyl cellulose to obtain carboxymethyl cellulose palmitate; adding a pH-sensitive natural dye indicator to obtain carboxymethyl cellulose palmitate nanoemulsion containing a pH-sensitive substance; then loading a natural polymer material to prepare a film material; finally adding the film material to the carboxymethyl cellulose palmitate to prepare a composite film, thereby obtaining the novel double-layer composite film. The double-layer composite film can be self-emulsified without adding a surfactant, and has the ability to load functional indicator (pH-sensitive color indicator) substances; meanwhile, the barrier performance of the film material, such as a chitosan film, to water vapor and oxygen is improved, and the double-layer composite film has a very promising application in food or fruit preservation. The method provided by the application is not only green in raw materials, but also uses a flow casting method, which can be applied to industrial production and has a good application prospect.

This invention relates to the field of surfactants, and discloses a surfactant composition and a nanoemulsion, as well as their preparation method and application. The composition comprises an amphoteric surfactant and a high-flash-point alcohol ether auxiliary, wherein the weight ratio of the amphoteric surfactant to the alcohol ether is 100:30-100. This nanoemulsion exhibits good kinetic stability and low viscosity, and can be used to enhance oil recovery in low-permeability reservoirs, ensuring that the nanoemulsion product is more convenient, safe, and environmentally friendly to use.

This invention discloses a nanoemulsion, its preparation method, and its application. By mass percentage, the nanoemulsion comprises the following components: 52.0%–78.5% glycerol, 20.0%–40.0% oil, and 1.5%–8.0% polyglycerol-10 stearate; wherein the oil is any one or a mixture of at least two of meadowfoam seed oil, jojoba seed oil, low-erucic acid rapeseed oil, olive fruit oil, and squalane. This invention prepares a 120nm nanoemulsion by high-pressure homogenization of the oil. Thus, by simply adding the nanoemulsion to water with stirring, it can achieve long-term stable dispersion in an aqueous system and is not prone to rancidity. This overcomes the limitations of conventional aqueous formulations in terms of component composition. High-pressure homogenization can be used to form nanoemulsions, enabling the development of more oil emulsions that can be stabilized in an aqueous system with simple stirring, thereby developing more stable aqueous spray products.

This invention discloses a photoactivated nanoparticle-based drug delivery material for immunoadjuvants, its preparation method, and its applications. The drug delivery material is constructed from photosensitizer monomers, crosslinking monomers, and immunoadjuvant prodrug monomers within a confined space of a nanoemulsion via a copper-free click polymerization reaction to form crosslinked polymer nanoparticles. The nanoparticle size is controllable, and the composition is precisely defined. Under physiological conditions, the drug delivery material exhibits good colloidal stability and high drug loading. Upon near-infrared light irradiation, the generated ROS can cleave the thioketone bonds, causing the nanoparticles to depolymerize and achieving photo-triggered, controllable release of the immunoadjuvant. Under photodynamic action, this drug delivery material efficiently generates reactive oxygen species to induce immunogenic cell death in tumor cells. Simultaneously, the released immunoadjuvant activates the TLR7 / 8 pathway, promotes dendritic cell maturation, and enhances the systemic anti-tumor immune response, thereby inhibiting the growth of tumors in situ and at distant sites, and reducing the risk of metastasis and recurrence.

The present disclosure relates to nanoemulsions of 5-amino-[4-(4-chlorobenzoyl)-3,5-dichlorobenzyl]-1,2,3-triazole-4-carboxamide (carboxy-amido-triazole or CAI), methods of preparing thereof, and their use in the treatment of inflammatory optic neuropathies.

The invention provides an epoxy adhesive nano-emulsion as well as a preparation method and application thereof. The epoxy adhesive nano-emulsion comprises the following components in parts by mass: 30-50 parts of epoxy resin, 10-20 parts of a water-based curing agent, 2-8 parts of a nanoscale emulsifier, 5-15 parts of modified nano-filler, 1-5 parts of an auxiliary agent and 20-40 parts of deionized water. The average particle size of the epoxy adhesive nano emulsion is 50 to 200 nm. According to the epoxy adhesive nano-emulsion disclosed by the invention, the epoxy resin is emulsified to a superfine particle size of 50-200nm through a nano-scale emulsification technology, so that the infiltration capacity of the emulsion in an underwater environment and the wettability of the emulsion to a wet concrete base material are remarkably enhanced, and a foundation is laid for realizing deep repair and reinforcement; a continuous three-dimensional network structure is constructed on the nanoscale by introducing the nano filler subjected to surface modification by a silane coupling agent, so that the interface bonding strength between a cured repair layer and a concrete matrix is remarkably improved.

This invention discloses an essential oil nanoemulsion based on amphiphilic polyamino acids, its preparation method, and its applications, relating to the field of emulsion preparation technology. The preparation method of the essential oil nanoemulsion includes: grafting amino acids with hydrophobic residues onto polyaspartic acid to synthesize amphiphilic polyamino acids; mixing the amphiphilic polyamino acids with essential oils uniformly to obtain an essential oil nanoemulsion with good stability; this invention also provides applications of the essential oil nanoemulsion in food, cosmetics, or pharmaceutical preparations. This invention, by grafting amino acids with hydrophobic residues onto polyaspartic acid to form amphiphilic polyamino acids; using the amphiphilic polyamino acids as emulsifiers to emulsify essential oils, and preparing essential oil nanoemulsions through a spontaneous emulsification method, not only improves the water solubility and stability of essential oils but also reduces their volatility and irritating odor, while also possessing good biocompatibility and biodegradability, expanding the applications of essential oils in the food, daily chemical, and pharmaceutical fields.

The invention belongs to the technical field of imbibition oil extraction, and provides a water-based nano-emulsion imbibition oil displacement agent and a preparation method thereof. According to the preparation method of the water-based nano-emulsion imbibition oil displacement agent, polyoxyethylene lauryl ether, sorbitan monopalmitate, mahogany petroleum sulfonate, an oily solvent, nano silicon oxide and water are uniformly mixed through a phase transition component method to prepare the water-based nano-emulsion imbibition oil displacement agent. The preparation method of the water-based nano-emulsion imbibition oil-displacing agent can effectively improve the crude oil recovery rate of unconventional oil reservoirs.

The invention relates to a biomass nanofiber composite membrane loaded with fat-soluble active matter nanoparticles as well as a preparation method and application of the biomass nanofiber composite membrane. The method comprises the following steps: mixing one or more of gelatin, polysaccharide and PVA with water to prepare a spinning solution, and carrying out electrostatic spinning to obtain a biomass nanofiber membrane; mixing the fat-soluble active matter with an organic solvent, adding water, ultrasonically crushing at normal temperature to obtain a fat-soluble active matter nano-emulsion, dissolving polysaccharide in water to obtain a polysaccharide solution, mixing the fat-soluble active matter nano-emulsion with the polysaccharide solution in proportion to obtain an electrostatic spraying precursor solution, and performing electrostatic spraying on the electrostatic spraying precursor solution; and loading an electrostatic spraying precursor solution onto the prepared biomass nanofiber membrane by adopting an electrostatic spraying mode, and finally obtaining the biomass nanofiber composite membrane loaded with the fat-soluble active matter nanoparticles. The composite membrane not only has good biocompatibility, but also has multiple effects of whitening, moisturizing, oxidation resistance and the like, can be used for producing products such as facial masks, facial filling patches and the like, and has a relatively good market prospect.

The invention discloses dexamethasone eye emulsion supramolecular hydrogel and a preparation method thereof, and belongs to the technical field of medicines. The dexamethasone eye emulsion supramolecular hydrogel is prepared from the following components in percentage by mass volume: 0.02 to 0.06 percent of dexamethasone, 0.5 to 5 percent of liquid oil, 1 to 6 percent of emulsifier and 1 to 5 percent of polyphenol. According to the dexamethasone ophthalmic emulsion supramolecular hydrogel provided by the invention, dexamethasone is used as a main drug, and a nanoemulsion is used as an insoluble drug carrier to improve the solubility of the dexamethasone ophthalmic emulsion supramolecular hydrogel; the emulsifier on the surface of the nanoemulsion can be self-assembled with polyphenol through hydrogen-bond interaction to form a supramolecular hydrogel network. After the preparation is dropped into the conjunctival sac, the drug-loaded nano-emulsion is gradually released and the free drug is further released under the shear thinning action caused by tear dilution and blinking, so that the long-acting treatment concentration is maintained on the ocular surface, and the defects that the drug is easily lost due to nasolacrimal duct drainage, the retention time of the ocular surface is short and the like in the traditional eye drops are effectively overcome.

The invention relates to the technical field of medical gel preparations, and discloses bioactive gel for treating oral ulcer and a preparation method thereof.The preparation method comprises the steps that medicine for treating the oral ulcer is dissolved in a solvent to prepare a solution, then the solution is prepared into nano-emulsion, and the nano-emulsion is prepared into the bioactive gel. The preparation method provided by the invention solves the problem of non-uniform dispersion of fat-soluble drugs in aqueous gel, improves the slow-release effect of drugs in the oral ulcer gel, enhances the treatment effect of the oral ulcer gel, and has the advantages that the oral ulcer gel is prepared by mixing the nano-emulsion and the gel matrix at a low temperature (less than 25 DEG C). The preparation method provided by the invention has the advantages that the problem of non-uniform dispersion of the fat-soluble drugs in the aqueous gel is solved; the bioactive gel for treating oral ulcer, provided by the invention, is high in biocompatibility and strong in adhesive force, not only has a good drug sustained release effect, but also can realize the simultaneous action of multiple functions of resisting inflammation, easing pain, promoting tissue regeneration and the like, promotes healing of the ulcer, shortens the treatment time and remarkably improves the treatment experience of a patient.

The invention provides a nano-emulsion which comprises water and the following raw materials in parts by weight: 10-15 parts of butanediol, 5-10 parts of glycerol, 2-4 parts of 1, 2-hexanediol, 5-6 parts of an emulsifier, 13-14 parts of squalane and 1-2 parts of glycerol tri (ethylhexanoic acid) ester. Through the synergistic effect of the components, the nano-emulsion which is small in particle size, narrow in distribution and high in stability is obtained, and the long-term stability of the properties such as the particle size of the emulsion can still be maintained under various conditions.

The invention provides a method for preparing a reversible thermally induced nano-emulsion under the condition of no addition of a surfactant. The method is based on a two-phase liquid system comprising a first liquid phase and a second liquid phase which are immiscible, and the vapor of the first liquid phase is dissolved in the second liquid phase by heating to a temperature sufficient to vaporize the first liquid phase to form a homogeneous mixture; the system is then cooled to a temperature below the saturation point of the first liquid phase in the second liquid phase, thereby inducing nucleation of the first liquid phase in the second liquid phase to form nanodroplets, resulting in a thermally induced nanoemulsion. The nano-emulsion can be decomposed and recovered into an original two-phase liquid system when being heated again, the reversible and controllable nano-emulsion preparation method is achieved through repeated heating-cooling steps, and the preparation method is suitable for various thermal response type intelligent conveying systems and other application scenes.

The invention discloses nano-particles with AIE characteristics and application of the nano-particles in LSD1 inhibitor detection, and belongs to the field of LSD1 inhibitor screening. The preparation method of the nanoparticles comprises the following steps: dissolving TPE powder in chromatographically pure CH2Cl2 to obtain an oil phase solution; the method comprises the following steps: dissolving recombinant H3K9me2 polypeptide in ultrapure water to obtain a water phase solution; mixing and stirring the water-phase solution and the oil-phase solution to form a primary emulsion, and ultrasonically crushing the primary emulsion to obtain a nano-emulsion; stirring and nitrogen blowing are synchronously carried out with the nano-emulsion, the organic solvent is removed, and an AIENP suspension is obtained; and filtering the AIENP suspension, and carrying out centrifugal purification to obtain the nano-particles with AIE characteristics. The method comprises the following steps: pre-incubating LSD1 and a gradient concentration LSD1 inhibitor, adding the pre-incubated LSD1 and gradient concentration LSD1 inhibitor into an AIENP system, detecting fluorescence intensity, calculating to obtain the IC50 value of the LSD1 inhibitor, and verifying the feasibility of the system for screening the LSD1 inhibitor.

The invention discloses a solid reconfigurable emulsion composition and a preparation method and application thereof, and belongs to the technical field of functional food and pharmaceutical preparations, and the composition is prepared from natural fish oil, natural lecithin, water-soluble micromolecular carbohydrates and optional flavoring agents through liquid active milk preparation and spray drying processes. Wherein the mass ratio of the natural fish oil to the natural lecithin is (1: 2)-(4: 1). By optimizing the component proportion and process parameters, a solid powder product which is good in redissolving performance, capable of being dissolved in water, recombined into a nanoscale emulsion, high in stability and capable of effectively masking fishy smell of fish oil is obtained. The product can be used for preparing food, health care products and medicines with health effects of regulating blood fat and the like.

OCR10KL (09 / 03 / 2569) This invention proposes a glove product with a nanoemulsion solution applied to the surface, composed of polymers. Long chain antimicrobial agents, antimicrobial enhancers, stabilizers, and intermediates containing... The preparation process involves mixing the stabilizers and intermediates together, then adding the polymer. The long-chain antimicrobial agent is mixed thoroughly, and then an enhancer is added to the resulting solution. Disinfection is achieved by mixing the components thoroughly and allowing them to set, resulting in a nanoemulsion solution. The solution is then used... The obtained nanoemulsion was prepared as gloves with the nanoemulsion solution applied to the surface.