The invention discloses a method for preparing tobacco essence microcapsules based on supercritical microchannel high
throughput. According to the method, a microchannel
reaction system special for the supercritical anti-
solvent process is constructed, a solution of tobacco essence and a
wall material and
supercritical carbon dioxide are pumped into a microchannel array according to the
flow ratio of (15-60): 1, anti-
solvent crystallization is carried out under the conditions of 8-15 MPa and 35-55 DEG C, and the microcapsules are obtained through decompression separation. According to the
system, a tree-shaped fractal flow channel
distributor and at least 64 parallel micro-channels are adopted, and
millisecond-level uniform mixing under the supercritical condition is achieved; the inner wall of the micro-channel is subjected to hydrophobic modification (with a
contact angle gt and 110 degrees) to prevent blockage; and online monitoring and
machine learning
intelligent control are combined to form a quality
closed loop. According to the method, the problems of wide
particle size distribution, low encapsulation efficiency, poor
thermal stability and poor production consistency of the nano microcapsules are solved at a time, the average particle size of the prepared microcapsules is 50-300 nm, PDI is smaller than or equal to 0.15, the encapsulation efficiency is larger than or equal to 99.5%, the fragrance carrying rate is larger than or equal to 40%, the microcapsules have excellent
thermal stability and slow release performance, and
linear amplification of productivity can be achieved.