690 results about "Nanocapsules" patented technology

Vesicles made from amphiphilic copolymers are disclosed. The amphiphilic copolymers can be ABA copolymers, where one of A and B is hydrophilic and the other is hydrophobic. AB copolymers can also be used. The copolymers may be crosslinked to form nanocapsules. Crosslinking can be accomplished using a variety of methods, including end to end polymerization of copolymers having terminal unsaturated groups. Molecules, such as membrane proteins, can be incorporated into the wall of the vesicles or nanocapsules.

The present invention provides a compositions and methods for the treatment of cancer, including pancreatic cancer, breast cancer and melanoma, in a human patient. The methods and compositions of the present invention employ curcumin or a curcumin analogue encapsulated in a colloidal drug delivery system, preferably a liposomal drug delivery system. Suitable colloidal drug delivery systems also include nanoparticles, nanocapsules, microparticles or block copolymer micelles. The colloidal drug delivery system encapsulating curcumin or a curcumin analogue is administered parenterally in a pharmaceutically acceptable carrier.

A carbon nanocapsule supported catalysts. At least one kind of catalytic metal particle is deposited to a carbon nanocapsule, wherein the carbon nanocapsule has the following formula: F(−M)n, in which F is the carbon nanocapsule, M is the catalytic metal particle, and n is the number of the catalytic metal particle. By applying the carbon nanocapsule as a catalyst support, the catalytic behavior of the catalytic metal particle is specialized, the dispersion is improved, and the catalytic effect is enhanced.

The present invention provides improved sustained release formulations of estradiol metabolites, including 2-hydroxyestradiol, 2-methoxyestradiol, 4-hydroxyestradiol and 4-methoxyestradiol, useful for therapeutic treatments. The invention also provides methods of producing sustained release forms of estradiol metabolites. The compositions of the present invention include microparticles, nanoparticles, patches, crystals, gels, rods, stints, pallets, discs, lozenges, wafers, capsules, films, microcapsules nanocapsules, hydrogels, liposomes, implants and vaginal rings. Compositions also include formulations for transdermal and intravenous delivery of estradiol metabolites. The present invention provides numerous improvements over previous forms of estradiol metabolites, such advantages including the sustained release of normally short half-life compounds to maintain therapeutic blood levels.

The present invention provides a compositions and methods for the treatment of Neurofibromatosis Type 1 and 2, in a human patient. The methods and compositions of the present invention employ curcumin or a curcumin analogue encapsulated in a colloidal drug delivery system, preferably a liposomal drug delivery system to target Merlin and proteins of the Merlin pathway. Suitable colloidal drug delivery systems also include nanoparticles, nanocapsules, microparticles or block copolymer micelles. The colloidal drug delivery system encapsulating curcumin or a curcumin analogue is administered parenterally in a pharmaceutically acceptable carrier.

The invention is aimed at nanocapsule systems characterized in that they have high stability during long periods of time. These systems are useful for the controlled release of pharmacologically or cosmetically active ingredients of highly lipophilic nature. The system comprises nanocapsules with an average size less than 1 μm dispersed in an aqueous medium, wherein the nanocapsules have a structure which comprises a lipophilic phase containing a phospholipid component and one or more saturated and/or unsaturated C₁₂-C₂₄ chain fatty acids or derivatives thereof; and a hydrophilic phase which comprises chitosan or a derivative thereof and a polyoxyalkylenated compound.

Provided are a liquid crystal display (LCD) device and fabricating method thereof. The liquid crystal display device, including a liquid crystal panel, includes: a first substrate, including: a pixel electrode, and a common electrode separated from the pixel electrode, a ratio of a width of the pixel electrode to a distance between the pixel electrode and the common electrode being in a range of about 1:1 to 1:7, and a nanocapsule liquid crystal layer formed on the first substrate, the nanocapsule liquid crystal layer including: a buffer material, and nanocapsules, each filled with liquid crystal molecules.

Nanoparticle composites and nanocapsules for guest encapsulation and methods for synthesizing same. One synthesis method includes providing a nanoparticle template; and forming a shell on the nanoparticle template by polymerizing a monomer on the nanoparticle template to form a nanoparticle composite defined by the shell and the nanoparticle template. Another synthesis method includes providing a nanoparticle template; forming a shell on the nanoparticle template by polymerizing a monomer on the nanoparticle template; and dissolving the nanoparticle template to thereby form a hollow nanocapsule defined by the shell. Another synthesis method includes providing a nanoparticle template carrying a guest molecule; and forming a shell on the nanoparticle template by polymerizing a monomer on the nanoparticle template to thereby encapsulate the guest molecule. This method can also include dissolving the nanoparticle template to form a nanocapsule defined by the capsule shell material, wherein the guest material resides in the nanocapsule.

A composition comprising:

• • (a) from about 0.01% to about 99%, by weight, of a fragrance oil, wherein the fragrance oil comprises about 5% or greater, by weight of fragrance oil, of a top note perfume raw material, or mixture of top note perfume raw materials, and wherein the top note perfume raw materials have a boiling point of less than, or equal to, about 250° C. at 1 atmosphere pressure;
  • (b) an entrapment material which is selected from the group consisting of polymers; capsules, microcapsules and nanocapsules; liposomes; pro-perfumes selected from more than 1 type of pro-chemistry; film formers; absorbents; cyclic oligosaccharides and mixtures thereof;
  • (c) greater than about 50% volatile solvent.

The present invention provides compositions wherein the light, fresh, fruity, citrus, green or delicate floral top note fragrance character remains detectable for greater than about 2 hours, preferably greater than about 4 hours, more preferably greater than about 6 hours, after the composition has been applied to the substrate.

The invention discloses an amphiphilic ternary polymer brush and a nano capsule. The amphiphilic ternary polymer brush has the following general formula, wherein A is polymer main chain, B is lipophilic polymer side chain, C is photo-crosslinked polymer side chain, D is hydrophilic polymer side chain, and the side chains B, C and D are randomly grafted onto the main chain A; and the nano capsule is prepared through dispersing the amphiphilic ternary polymer brush into an oil-water two-phase system, and then performing light crosslinking reaction or reaction initiated by light. The amphiphilic ternary polymer brush solves the difficulty that the particle size of the capsule can not be adjusted and controlled effectively by using the conventional segmented copolymers, and the size of the prepared photo-crosslinked nano capsule is easily adjusted and controlled; the nano capsule prepared by the emulsion self-assembly method is simple in operation and easy to use in large-scale preparation; the prepared hollow nano capsule is large in casting quantity; the photo-crosslinked nano capsule provided by the invention is stable, and according to the light crosslinking method, nontoxicity and safety are reliazed, and the environmental protection is realized. The amphiphilic ternary polymer brush has the following general formula: A-g-(B-r-C-r-D).

The invention discloses a hollow core-shell nanometer mesoporous medicament carrying system with magnetism and luminescent performance. In the medicament carrying system, a magnetic Fe3O4 hollow capsule is used as an inner core, mesoporous SiO2 is used as a shell layer, and an organic luminescent material and a biocompatible polymer are modified on the outer surface of the shell layer. A preparation method of the medicament carrying system comprises the following steps of: firstly, preparing monodisperse fusiform beta-FeOOH nanoparticles by a hydro-thermal method, coating mesoporous silicon dioxide on the surfaces of the nanoparticles, removing a pore-forming agent through thermal treatment, and simultaneously, converting the inner core into alpha-Fe2O3 from the beta-FeOOH, so that a cavity is generated in the inner core so as to form a hollow nanometer capsule structure; secondly, converting the inner core into the magnetic Fe3O4 hollow capsule through reduction treatment; and finally, modifying the organic luminescent material and the biocompatible polymer on the surface of the magnetic mesoporous nanometer capsule. The nanometer composite capsule of the invention has the advantages of core-shell structure and cavity structure, uniform particle size, high biocompatibility and excellent magnetism.

A thermal interface material (40) includes a polymer matrix and a number of carbon nanocapsules incorporated in the polymer matrix. The thermal interface material is sandwiched between a heat source (30) having a high density and a heat sink (50). The thermal interface material can provide a maximum surface contact area and can increase thermal conductivity between the heat source and the heat sink.

A method of inhibiting the activity or production of cytokines or growth factors associated with vascular restenosis, by administering to an individual an effective amount of an active ingredient comprising a bisphosphonate particle or a bisphosphonate particulate. The bisphosphonate may be encapsulated, embedded or adsorbed within the particle, dispersed uniformly in the polymer matrix, adsorbed on the particle surface, or in combination of any of these forms. The particles include liposomes or inert polymeric particles, such as microcapsules, nanocapsules, nanoparticles, nanospheres, or microparticles. The particulates include any suspended or dispersed form of the bisphosphonate which is not encapsulated, entrapped, or adsorbed within a polymeric particle. The particulates include suspended or dispersed colloids, aggregates, flocculates, insoluble salts and insoluble complexes of the active ingredient. The cytokines and growth factors include, but are not limited to interleukin 1-β, matrix metalloproteinase-2, and platelet-derived growth factor β (PDGFβ).

Disclosed is a liquid crystal display device that may include a first substrate; a first electrode on the first substrate, the first electrode including a plurality of first inclined planes; a nanocapsule liquid crystal layer on the first electrode, the nanocapsule liquid crystal layer including a plurality of nano-sized capsules dispersed in a buffer layer, each of the plurality of nano-sized capsules including nematic liquid crystal molecules having a negative dielectric constant anisotropy; and a second electrode on the nanocapsule liquid crystal layer, the second electrode including a plurality of second inclined planes facing the plurality of first inclined planes, wherein the nanocapsule liquid crystal layer is substantially, optically isotropic in a normal state, and is optically anisotropic when a voltage is applied to the first and second electrodes.

A composition comprising: (a) a fragrance oil comprising: (i) top note perfume raw material, or mixture of perfume raw materials, with a boiling point of less than, or equal to, about 250° C. at 1 atmosphere pressure; (ii) middle or base note perfume raw material, or mixture of perfume raw materials, with a boiling point of greater than 250° C. at 1 atmosphere pressure; (b) an entrapment material which is selected from the group consisting of polymers; capsules, microcapsules and nanocapsules; liposomes; pro-perfumes selected from more than 1 type of pro-chemistry; film formers; absorbents; cyclic oligosaccharides and mixtures thereof; (c) greater than 50% volatile solvent; wherein the weight ratio of the top note perfume raw materials to middle or base note perfume raw materials within the fragrance oil is in the range from about 1:20 to about 20:1. The present invention provides compositions wherein the light, fresh, fruity, citrus, green or delicate floral top note fragrance character remains detectable for greater than about 2 hours, preferably greater than about 4 hours, more preferably greater than about 6 hours, after the composition has been applied to the substrate.

A composition is provided accompanying nonoparticles having diameters in the range of about 100 to 800 nanometers with hollow cores and outer shells with mechanical properties such that they rupture on exposure to predetermined ultrasound energy. The composition is useful for identifying sentinel lymph nodes.

The present invention provides a polymerizable organosilicon nanocapsule, which includes: a nanoscale core A, which includes: at least one particle comprising at least one oxide or mixed oxide, KA-O, of at least one metal or semimetal selected from the group including main groups 2 to 6 of the Periodic Table, transition groups 1 to 8 of the Periodic Table, lanthanides, and mixtures thereof; and an organosilicon shell B, which includes: at least one organosilicon compound having the formula (Ia):

(Si′O—)_xSi—R   (Ia)

wherein R is a vinyl or allyl group; wherein x is a number from 0 to 20; wherein remaining free valences of Si are each independently (KA-O)—, SiO— or -Z; wherein remaining free valences of Si′ are each independently (KA-O)—, SiO—, -R, or -Z; wherein the Z's are each independently hydroxyl or alkoxy radicals; and wherein each Si and Si′ in the shell B have not more than one R group attatched thereto.

The invention discloses a slow release fertilizer applicable to water-fertilizer integration. The slow release fertilizer is a nano capsule slow release fertilizer prepared from nutritional ingredients as core materials and a slow soluble film-forming polymer as a capsule wall material. The slow release fertilizer can be evenly dispersed into the water to form a colloidal solution and achieves the slow release and controlled release targets. The invention further provides a preparation method of the slow release fertilizer. The method comprises the following steps: dissolving the slow soluble film-forming polymer into an organic solvent which is not mixed and dissolved with the water; dispersing a core material water solution into the organic solvent to form a water-in-oil W/O emulsion; and adding the W/O emulsion to the water solution containing protective colloid to disperse, so as to form a W/O/W emulsion, and then evaporating a solvent, so as to form the nano capsule. The slow release fertilizer can be evenly dispersed into water to form the colloidal solution, and can be irrigated together with water; and the capsule wall material is a slow soluble film-forming polymer, and can be slowly dissolved into soil to achieve the controlled release target, secondary pollution to the soil is not generated, and the slow release fertilizer has market function value.

The invention discloses an amphipathic ternary molecular brush polymer and a nanocapsule. The amphipathic ternary molecular brush polymer has a general formula shown below, wherein A is a main polymer chain, B is a side lipophilic macromolecular chain, C is a side macromolecular chain with a hydrophilic chemical cross-linking structure, D is a side lipophilic macromolecular chain, and the side chains B, C and D are randomly grafted to the main chain A. The nanocapsule is obtained by dispersing the amphipathic ternary molecular brush polymer in an oil and water two-phase system for a chemical cross-linking reaction. The amphipathic ternary molecular brush polymer constructed multichannel nanocapsule, disclosed by the invention, solves the problem that a traditional segmented copolymer is difficult to adjust and control multiple channels of the nanocapsule efficiently; and the channel structure and size of the prepared nanocapsule are easy to adjust and controllable. As an emulsion self-assembling method is adopted for preparing the nanocapsule, simple operation is obtained and the nanocapsule is easy to prepare in a large scale; the prepared hollow nanometer nanocapsule covering amount is great; and the nanocapsule disclosed by the invention has a steady structure after hydrophilic chemical cross-linking. A-g-(B-r-C-r-D).