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80 results about "Nanocapsules" patented technology

A nanocapsule is a nanoscale shell made from a nontoxic polymer. They are vesicular systems made of a polymeric membrane which encapsulates an inner liquid core at the nanoscale. Nanocapsules have many uses, including promising medical applications for drug delivery, food enhancement, nutraceuticals, and for self-healing materials. The benefits of encapsulation methods are for protection of these substances to protect in the adverse environment, for controlled release, and for precision targeting. Nanocapsules can potentially be used as MRI-guided nanorobots or nanobots, although challenges remain.

Preparation method and application of ceramic glaze layer protecting and repairing material

PendingCN121537228ACoatingsCrazingPolypropylene
The invention discloses a preparation method and application of a ceramic glaze layer protecting and repairing material, and belongs to the technical field of cultural relic protection. The preparation method comprises preparation of a core-shell self-repairing nanocapsule, and the preparation of the core-shell self-repairing nanocapsule comprises the following steps: reacting a calcium chloride solution with a sodium hydroxide solution, then adding sodium polyacrylate and nano ZnO, and carrying out dispersion, centrifugation, washing and other operations to prepare the nano Ca (OH) 2-ZnO composite material. The nano Ca (OH) 2-ZnO composite material of the core-shell self-repairing nanocapsule can be rapidly released through the 3.5 nm aperture of the mesoporous SiO2 shell, glaze layer cracks are physically filled and react with CO2 in air to generate CaCO3 crystals, crack plugging is achieved, meanwhile, dynamic disulfide bonds of a PU layer are broken and recombined under stress stimulation, a crack interface is repaired through chemical bonding, and the performance of the core-shell self-repairing nanocapsule is improved. The 24-hour crack repair rate is greater than or equal to 96%, and the limitation of'one-time repair 'of a traditional material is solved.
Owner:XIAN UNVERSITY OF ARTS & SCI

Biodegradable hydraulic oil composition and preparation method of hydraulic oil

PendingCN121991749AImprove Oxidation Stabilitypromote degradationBase-materialsDemulsifierFiltration
The invention relates to a biodegradable hydraulic oil composition and a preparation method of hydraulic oil, and relates to the technical field of hydraulic oil compositions.The hydraulic oil composition comprises, by weight, 20-37% of ester oil, 5-10% of refined vegetable oil and 5-10% of a demulsifier, and the total weight of the ester oil, the refined vegetable oil and the demulsifier is 100%. The content of the refined vegetable oil is 62-79.9 wt%, the content of the demulsifier is 0.1-1 wt%, and the preparation method of the refined vegetable oil comprises the following steps: pre-loading a nanocapsule with an antioxidant as an inner core in activated clay, loading the activated clay pre-loaded with the nanocapsule into deacidified oil, and filtering to obtain the refined vegetable oil. The hydraulic oil composition disclosed by the invention has excellent biodegradability and also has the technical effects of relatively good oxidation stability and viscosity-temperature property.
Owner:HUBEI BODA SPECIAL LUBRICANT CO LTD

Traditional Chinese medicine aromatic penetration enhancer containing plant cell extract and preparation method of traditional Chinese medicine aromatic penetration enhancer

The invention discloses a plant cell extract-containing traditional Chinese medicine aromatic penetration enhancer and a preparation method thereof, and the penetration enhancer comprises the following components in parts by mass: 8-15 parts of storax nano-vesicles, 3-8 parts of agilawood nano-vesicles, 1-5 parts of refined turpentine, 0.5-3 parts of panax notoginseng saponins, 0.5-3 parts of rhododendron dauricum oil and 20-35 parts of grape seed oil, the storax nano-vesicles and the agilawood nano-vesicles are exosome-like nano-vesicles extracted from plant secretion, and the particle size of the vesicles is 50-200 nm. Skin interstices are opened, skin meridians and blood are dredged, and accordingly relieving, inflammation resisting, redness improving and skin barrier repairing are achieved.
Owner:GUANGZHOU LUGUO FANGHUA BIOTECHNOLOGY CO LTD

Preparation method of peppermint essence

The invention relates to a preparation method of peppermint essence, which solves the problems of quick volatilization and poor durability of the traditional peppermint essence by optimizing the combination of essence components and a slow-release carrier by adopting a multi-layer microcapsule slow-release technology and a nanocapsule technology. According to the method, essence components such as menthol, menthone and leaf isovalerate are mixed with at least two layers of microcapsules, the outer layer microcapsules slowly release fragrance, the inner layer microcapsules quickly release fragrance, and it is ensured that the fragrance is kept for a long time in the using process. Meanwhile, the essence is uniformly dispersed in different carrier systems through ultrasonic-assisted emulsification by adopting a nanocapsule technology, so that the stability and dispersity of the essence are improved. In addition, the temperature-responsive and pH-responsive polymer materials are introduced, so that the release rate of the essence can be adjusted according to the external environment, and the adaptability of the essence is further enhanced.
Owner:GUANGZHOU ZHENXIN FLAVORS & FRAGRANCES CO LTD

Preparation method of photoresponse type UV regulation and control material and 3A optical film

The invention discloses a preparation method of a light response type UV regulation and control material and a 3A optical film, and relates to the technical field of optical films.The preparation method comprises the steps that spiropyrane is dissolved in ethyl acetate to form an oil phase, and first liquid is obtained; dispersing nano silicon dioxide in a water phase containing gelatin to obtain a second liquid; stirring and mixing the first liquid and the second liquid to form an emulsion; evaporating the emulsion at 55-65 DEG C for at least 12 hours to form a spiropyrane-silicon dioxide hybrid nanocapsule; the spiropyrane-silicon dioxide hybrid nanocapsule is dispersed into light-cured polyacrylate, and a light response type UV regulation and control material is obtained; the 3A optical film comprises a light response type UV regulation and control layer, and the material of the light response type UV regulation and control layer is a light response type UV regulation and control material. The 3A optical film realizes flexible regulation and control of absorption of ultraviolet rays according to different weather scenes.
Owner:YUEDA OPTRONICS TECH(ZHEJIANG) CO LTD

Nanocapsules for delivery of cell modulating agents

The present disclosure relates to a polymer nanocapsule comprising a ribonucleoprotein complex and a method for its delivery.In some embodiments, the polymer nanocapsule comprises a polymer shell and a ribonucleoprotein complex, wherein the polymer shell comprises at least one positively charged monomer, at least one neutral monomer, and a crosslinker.Also disclosed is a conjugate of the polymer nanocapsule linked to one or more targeting moieties and / or one or more stabilizing moieties.
Owner:CENTEON A LLC OF DELAWARE

Display apparatus and electronic apparatus including the display apparatus

Provided is a display apparatus including a display panel, an optically clear adhesive (OCA) over the display panel, and an auxiliary layer between the display panel and the OCA and including a nanocapsule and an OCA composition, wherein the nanocapsule is a gas-generating particle and has a diameter of at least about 100 nm and not more than about 2 μm.
Owner:SAMSUNG DISPLAY CO LTD +1

Self healing plasma electroytic oxidation coating

PendingUS20260117394A1Anti-corrosive paintsPlasma electrolytic oxidationElectrolysis
An aircraft component including an aluminum substrate and a plasma electrolytic oxidation (PEO) coating disposed on the aluminum substrate. The PEO coating includes a plurality of cavities. A set of nano capsules disposed in the plurality of cavities, with at least a portion of the nano capsules in the set of nano capsules containing a corrosion inhibitor.
Owner:HAMILTON SUNDSTRAND CORP

A method for synthesizing catalase nanocapsules based on gas-liquid two-phase flow microfluidic technology and application

The application discloses a method for synthesizing catalase nanocapsules based on gas-liquid two-phase flow microfluidic technology and application. Nitrogen is used as a gas phase, and a liquid phase containing acrylated catalase, a monomer mixture and a crosslinking agent is used to form Taylor flow in a microfluidic chip. The internal vortex of the gas-liquid interface is used to enhance the mixing efficiency, and in-situ radical polymerization on the surface of the enzyme is realized. By screening six microfluidic chips with different structures, the geometric parameters of the chip and the hydrodynamic conditions are optimized, and the particle size uniformity and enzyme activity retention rate of the nanocapsules are significantly improved. The application also discloses a continuous flow reactor system for loading the obtained nanocapsules on macroporous resin microspheres to construct a continuous flow reactor system, and the system is used for efficient degradation of hydrogen peroxide in semiconductor wastewater. The method has the advantages of high mixing efficiency, mild reaction conditions, continuous production and the like, the obtained nanocapsules have the advantages of narrow particle size distribution, high enzyme activity and good stability, and are suitable for the field of industrial wastewater treatment.
Owner:FUZHOU UNIV

Three-signal sensor based on aptamer and pH response double-gating nanocapsule as well as preparation method and application of three-signal sensor

The invention belongs to the technical field of food safety and rapid detection, and discloses an acetamiprid residue three-signal (colorimetric, photo-thermal and fluorescent) synergistic detection method based on aptamer and pH response double-gated nanocapsules. According to the invention, UiO-66 is used as a nano container for packaging a signal molecule TMB, and an aptamer (Apt) and chitosan (CS) are assembled on the surface of UiO-66, so that the nano capsule (UiO-66 (at) TMB (at) Apt (at) CS) which has dual response to the aptamer and pH and can accurately release TMB is constructed. The method comprises the following steps: under an acidic condition, after a target object is added, CS cracking and specific binding of Apt and the target object lead to release of TMB, firstly, HRP and H2O2 are added, and then colorimetric detection is carried out; then, irradiating the solution subjected to color development by using 808 nm laser, and carrying out photo-thermal detection; finally, a proper amount of QDs is added for fluorescence detection, and three-signal detection of acetamiprid residues is achieved.
Owner:YANGZHOU UNIV

AlN / Fe-C-C nanocapsule as well as preparation method and application thereof

The invention provides a preparation method of an AlN / Fe-C-C nanocapsule, and relates to the technical field of nanomaterials, a mixed molding target material containing Fe, Al and C is taken as an anode, a graphite electrode is taken as a cathode, and arc discharge is carried out by adopting a plasma arc evaporation process in the atmosphere of catalytic gas and working gas containing nitrogen, so that the AlN / Fe-C-C nanocapsule is prepared. The preparation method comprises the following steps: adopting a mixed molding target material containing Fe, Al and C as an anode to form an AlN / Fe-C-C nanocapsule with a graphene matrix; wherein the graphene can maintain the dielectric loss capability at a high frequency band, and the AlN / Fe-C-C takes AlN and Fe-C as a core and takes a carbon shell as a shell, so that good impedance matching can be realized, and the material has the dielectric loss capability at a low frequency band, thereby solving the problem of narrow wave-absorbing frequency band of the existing nanocapsule material.
Owner:INST OF METAL RESEARCH - CHINESE ACAD OF SCI

Nanocapsule SMCPM and application thereof in preparation of medicine for treating or preventing osteosarcoma and pulmonary metastasis

The invention relates to the technical field of biological medicines, and particularly discloses a nanocapsule SMCPM and application thereof in medicines for treating or preventing osteosarcoma and pulmonary metastasis. The SMCPM is composed of a photosensitizer Ce6 carried by mesoporous silicon oxide-manganese oxide particles, an NRF2 inhibitor ML385 and an OS targeting peptide PT-7. Experiments prove that the SMCPM is high in penetrating power and strong in cell killing effect; by down-regulating NRF2 expression and reversing nuclear translocation, a biochemical inhibitory microenvironment can be effectively repaired, the tolerance of cells to active oxygen and epithelial-mesenchymal transition activated and induced by a NOTCH1 signal axis are remarkably reduced, the oxidative stress level of the cells is enhanced, and PIT-induced immunogenic cell death is promoted; the released Mn < 2 + > and double-stranded DNA can regulate and control an immunosuppressive microenvironment by activating an STING pathway in cells, thereby inhibiting the growth of osteosarcoma and preventing lung metastasis.
Owner:ZHONGNAN HOSPITAL OF WUHAN UNIV

Liquid crystal nanocapsules and capsule solutions, optical films, optical devices, transmittance variable devices using the same

This invention relates to liquid crystal nanocapsules and capsule solutions, optical films, optical devices, and transmissivity devices using the same, wherein the liquid crystal nanocapsules comprise: a core containing liquid crystal; and a polymer shell formed on the surface of the core; wherein the sum of the initial temperature change value according to Formula 1 and the peak temperature change value according to Formula 2 is 37.5°C or less.
Owner:LG CHEM LTD

A dual-mode nanocapsule and its preparation method

A method for preparing bimodal nanocapsules includes: preparing a solution of mesoporous silica and deionized water, adding chloroauric acid solution and stirring, then adding sodium borohydride solution under ice bath stirring conditions to obtain gold nanoparticle-modified mesoporous silica; preparing a solvent of ultrapure water and gold nanoparticle-modified mesoporous silica, then sequentially adding a fluorescence quencher, a fluorescent molecule, and 4-mercaptophenylboronic acid to react separately to obtain bimolecularly modified nanoprobes; and mixing an adenosine-5′-triphosphate nucleic acid aptamer solution with the nanoprobes using ultrapure water as a solvent to obtain nucleic acid aptamer-encapsulated bimodal nanocapsules. This invention provides a simple, mild, environmentally friendly, and low-cost preparation method. The bimodal nanocapsules prepared by this invention can simultaneously monitor the levels of hydrogen peroxide and adenosine-5′-triphosphate (ATP) in cells using fluorescence and surface-enhanced Raman scattering (SERS) techniques, which can be used for early disease monitoring.
Owner:XUZHOU NORMAL UNIVERSITY

Preparation of glycerol nanocapsules and their use as additive in a hydrophobic lubricant

The invention herein disclosed refers to a method for preparation of glycerol nanocapsules (GNCs), adapted as an additive in a hydrophobic lubricant for improving lubricity in a tribological system, further to a glycerol nanocapsule (GNC) and finally to the respective use. The method comprises the steps of providing a continuous phase comprising at least a polyalphaolefin (PAO) and a dispersed phase comprising at least glycerol (GLY), of - mixing the continuous phase and the dispersed phase and performing high-pressure homogenization with a microfluidizer resulting in a minielmulsion comprising glycerol nanodroplets (GNPs). Further, adding a diisocyanate crosslinking agent (TDI) to the miniemulsion is comprised, leading to a polymerization reaction of the diisocyanate cross-linking agent (TDI) and glycerol (GLY) at the interfaces of the glycerol nanodroplets (GNPs) dispersed in the polyalphaolefin (PAO), resulting in formation of crosslinked glycerol-based polyurethan shells encapsulating a core of unreacted glycerol (GLY). Thereby glycerol nanocapsules (GNCs) are obtained, comprising a core of unreacted glycerol (GLY) encapsulated in a crosslinked glycerol-based polyurethan shell.
Owner:FUCHS PETROLUB AG

Nanocapsule with high transparency as well as preparation method and application of nanocapsule

The invention relates to a nanocapsule with high transparency as well as a preparation method and application thereof. The preparation method comprises the following steps: carrying out polymerization reaction on a polyisocyanate compound, at least one hydrophilic diol compound and at least one hydrophobic diol compound to form an amphiphilic block copolymer with an isocyanate end group; the preparation method comprises the following steps: dissolving an amphiphilic block copolymer and an active component into a water-soluble organic solvent, dropwise adding deionized water or an organic solvent at a speed of 10-100 mL / min under mechanical stirring, and carrying out self-emulsification to form a uniformly dispersed dispersion; and adding a polyamine compound into the dispersion, and carrying out a cross-linking reaction to form the nanocapsule. Through material design and a process route, the contradiction that high-activity component loading capacity and high optical transparency cannot be achieved at the same time in the field of nano carriers is systematically solved.
Owner:ZHIWEI (SHENZHEN) MEDICAL TECHNOLOGY CO LTD

Intelligent nano-capsule oil-displacing agent, preparation method and application thereof

ActiveCN121975509BMeth-Isopropyl
The application discloses an intelligent nano-capsule oil displacement agent and a preparation method and application thereof, and belongs to the technical field of oil exploitation. The preparation method comprises the following steps: (1) adding N-isopropyl acrylamide, methacryloyl ethyl sulfobetaine and unsaturated phosphate and an emulsifier into water to obtain an aqueous phase; (2) adding modified nanoparticles into a first solvent to obtain an oil phase; and (3) adding the oil phase into the aqueous phase, stirring and uniformly mixing, and then adding an initiator under the condition of inert gas to obtain the intelligent nano-capsule oil displacement agent. The intelligent nano-capsule oil displacement agent can be adjusted according to the actual temperature of an oil reservoir, realizes the effects of easy pumping at low temperature and stable displacement at high temperature, and further improves the oil recovery rate.
Owner:DESHI ENERGY TECH GRP CO LTD

Dyeing microcapsules and their use in the dyeing and finishing of machine washable silk

ActiveCN118718912BOrganic dyesDyeing processPolymer scienceAmino acid side chain
The present application relates to a kind of dyed microcapsules and its application in the dyeing and finishing of machine washable real silk, belong to the technical field of microcapsule.The amino acid side chain that can produce strong hydrogen bond effect is introduced into capsule shell layer for the first time in the present application, the content of metal coordination bond, hydrogen bond is regulated, the crosslinking density of nanocapsule and silk is improved, and finally the preparation of persistent adhesive force nanocapsule is realized.Silk fibroin based on biological protein macromolecule is used as wall material and applied on silk, better combined with silk, and has good biocompatibility and hand feeling, wall material is prepared by emulsion polymerization method, and the core material is silk microcapsule dye of natural fungal dye, using post-mordanting technology, while dyeing real silk fabric, introduce curing agent, carry out wash-resistant finishing, so that the originally relatively fragile silk fabric can be machine washed.
Owner:HIGH FASHION CHINA CO LTD

Nanocapsule with tannic acid molybdenum coordinated and wrapped DNase as well as preparation method and application of nanocapsule

The invention discloses a tannic acid molybdenum coordination coated DNase nanocapsule as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. According to the preparation method, molybdenum and tannic acid are utilized to form an MPN nanocapsule, DNase II is carried, and the Mo-TA-coated DNase II nanocapsule is constructed; the positively charged metal phenolic network nanoparticle (MPN NPs) shell has remarkable advantages in the aspect of adsorbing circulating free DNA (cfDNA), the porous structure and rich surface functional groups provide high adsorption capacity and rapid adsorption kinetics, and the cfDNA can be efficiently captured. MPNs also has the characteristics of good biocompatibility, easy carrying and the like, and the MPNs has good PH responsiveness, so that DNase II can be accurately released in lysosome and effectively hydrolyzed in cells, the inflammatory reaction caused by cfDNA is blocked by using cfDNA, and meanwhile, the interburial effect of macrophages is recovered; mo and TA have oxidation-reduction ability, can effectively improve the stress state of cells and mitochondrial dysfunction, obviously inhibit the generation of cfDNA, and realize the full-period management from symptom treatment to root cause treatment.
Owner:STOMATOLOGICAL HOSPITAL OF CHONGQING MEDICAL UNIV

Nanocapsule-based thermal insulation functional masterbatch and preparation method thereof

A nanocapsule-based thermal insulation functional masterbatch and a preparation method thereof are provided. The nanocapsule-based thermal insulation functional masterbatch is prepared by mixing a polymer substrate, an organic-inorganic composite nanocapsule, and an auxiliary agent to allow granulation, where the nanocapsule is added at 1 wt % to 20 wt % and the auxiliary agent is added at 0.2 wt % to 0.5 wt % by weight percentage, while the polymer substrate is added as a balance. The nanocapsule is prepared by emulsification prepolymerization, polymerization, and nano-compounding. Compared with general thermal insulation functional masterbatch, the nanocapsule-based thermal insulation functional masterbatch shows outstanding stability, higher thermal insulation, and excellent thermal insulation performance.
Owner:SHANGHAI HUZHENG IND CO LTD

Method for producing silica nanocapsules containing water-soluble compounds, method for producing porous silica nanocapsules, silica nanocapsules containing water-soluble compounds, and porous silica nanocapsules

PendingJP2026086263AOrganic active ingredientsSilicaSilicon alkoxideNanocapsules
This invention provides a method for producing silica nanocapsules without using reagents that are difficult to handle. [Solution] The present invention provides a method for producing silica nanocapsules containing a water-soluble compound, comprising hydrolyzing and dehydrating a silicon alkoxide in an aqueous solution containing a water-soluble compound to produce silica, wherein the water-soluble compound has a pyranone ring and a hydroxyl group. Furthermore, the present invention provides a method for producing porous silica nanocapsules, further comprising dispersing the water-soluble compound-encapsulated silica nanocapsules obtained by the above method in water or an aqueous solution to elute the water-soluble compound from the water-soluble compound-encapsulated silica nanocapsules.
Owner:TOSOH CORP +1

Probiotic stock solution, preparation method thereof and plant nutrient solution

The invention provides a probiotic stock solution, a preparation method thereof and a plant nutrient solution, and belongs to the field of fertilizers. The probiotic stock solution mainly comprises a component A, a component B, a component C and a component D; the component A encapsulates the component C and the component D through crosslinking to form the nanocapsule; the preparation method comprises the following steps: washing rice and the like, and mixing the washed rice and the like with soybean milk, dregs, brown sugar and the like; culturing the complex microbial inoculant, and performing centrifugal washing; the nanocapsule is prepared by crosslinking and encapsulating the sodium alginate, the humic acid and the chitosan. Finally, mixing the nanocapsule with a component B to prepare a stock solution; the nanocapsules in the probiotic stock solution can effectively protect the probiotics and nutrients, realize long-term stable release, have the cost advantage and green development concept, and can be further used for preparing a plant nutrient solution.
Owner:PANZHIHUA XINGPENG BIOENGINEERING CO LTD

Silica gel and graphene composite waterproof and mildewproof heat-conducting gasket for server room

PendingCN121249161APolymer scienceBoron nitride
The invention discloses a silica gel and graphene composite waterproof and mildewproof heat-conducting gasket for a server room. The silica gel and graphene composite waterproof and mildewproof heat-conducting gasket comprises 55-70% of a modified silica gel matrix, 20-35% of a core-shell structure heat-conducting filler, 1-10% of a response type mildewproof agent, 1-5% of an interface compatilizer and 0.5-5% of a pore regulating agent, the modified silica gel matrix takes hydroxyl-terminated polydimethylsiloxane as a main chain and is obtained by modifying through a dynamic cross-linking agent; the core-shell structure heat-conducting filler takes graphene quantum dots as a core and boron nitride nanosheets as a shell, and the mass ratio of the core to the shell is 1: (3-8); the responsive mildew inhibitor is a temperature-sensitive nanocapsule, the shell is poly (N-isopropylacrylamide), and the inner core is a plant source mildew-proof compound. Through the multi-layer structure design, the heat conductivity coefficient and the water absorption rate are smaller than or equal to 0.02%, the mildew-proof grade reaches the 0 grade, and the self-adaptive interface contact characteristic is achieved.
Owner:广州市摩支天材料科技有限公司

High-stability beet red nanocapsule for enzymatically regulating and controlling multilayer interface composite network and preparation method of high-stability beet red nanocapsule

The invention discloses a high-stability beet red nanocapsule capable of enzymatically regulating and controlling a multilayer interface composite network and a preparation method of the high-stability beet red nanocapsule. Through the synergistic effect of partial thermal denaturation of a whey protein isolate and low-ester pectin, transglutaminase is introduced at a proper pH value to realize enzymatic crosslinking; a three-dimensional compact structure cooperatively constructed by covalent bonds and electrostatic interaction is formed, the system stability and the pigment fixing capacity are remarkably improved, the powder obtained by adopting maltodextrin to assist spray drying is remarkably improved in flowability and resolubility, and meanwhile, the powder has high photo-thermal stability. According to the invention, the proportion of the three components is systematically optimized, so that the balance between the structural compactness and the redissolution rate is realized, and the capsule keeps excellent stability during processing and storage. Compared with a traditional single protein or polysaccharide system, the enzymatic cross-linked composite network has higher embedding rate and stronger photo-thermal stability, an efficient technical scheme is provided for application of beet red in beverages, dairy products and bakery products, and meanwhile the application value of natural pigments in food is expanded.
Owner:OCEAN UNIV OF CHINA +1

Dtrim24 biocompatibility-based Anti-atherosclerotic nanoparticles

PCT designated stageWO2026060590A1Organic active ingredientsInorganic non-active ingredientsBiomimetic nanoparticlesMagnetite Nanoparticles
The present application relates to the technical field of nanocapsules for medical preparations, and particularly relates to dTRIM24 biocompatibility-based anti-atherosclerotic nanoparticles composed of nanoparticles and M1 macrophage membrane vesicles. By using a microfluidic photoporation chip, the nanoparticles are encapsulated by the M1 macrophage membrane vesicles. The nanoparticles are obtained by combining dTRIM24 and Fe3O4 magnetic nanoparticles. The biomimetic nanoparticles of the present application reasonably solve the problems of poor specificity and low efficiency, and have improved anti-atherosclerotic plaque-targeting and biological homology.
Owner:THE THIRD AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY (GUANGZHOU SEVERE MATERNAL TREATMENT CENTER GUANGZHOU ROUJI HOSPITAL)

A method for automatically repairing a surface-scratched prism sheet

This invention relates to the field of prism sheet technology, specifically to a method for automatically repairing prism sheets with surface scratches. By improving the nanocapsule production process and adopting more economical preparation methods, production costs are reduced, resulting in self-healing prism sheets with lower production costs and better market competitiveness. By finding more suitable material combinations to improve the adhesion and toughness of the nanocapsules, the method avoids the situation where the nanocapsules break and lose their self-healing ability when subjected to large forces. Furthermore, by employing higher precision equipment and technology, as well as more stringent quality control management, the technical difficulty and control precision of the nanocapsule automatic repair technology are increased. This addresses the technical problems of high production costs and insufficient adhesion of existing nanocapsules due to the need for high-precision equipment and technology in their production process.
Owner:QINGDAO ZHUOYINGSHE TECH CO LTD

A rapamycin-g4h nanocapsule, a preparation method and application thereof

The application relates to a rapamycin-G4H nanocapsule, a preparation method and application thereof. The preparation method of the rapamycin-G4H nanocapsule comprises the following steps: S1. preparing a rapamycin micelle by adopting a film hydration method; S2. modifying a dibenzocyclooctyne amplification primer on the surface of the rapamycin micelle through a click chemistry reaction to obtain a rapamycin micelle modified with the amplification primer; S3. taking a linear DNA molecule as a template, and synthesizing a circular amplification template through an intramolecular cyclization reaction; and S4. incubating the circular amplification template, the rapamycin micelle modified with the amplification primer, a thermophilic DNA polymerase, a pyrophosphatase, dNTP and Co-G4-haem DNAzyme under the condition of a thermophilic DNA polymerase reaction buffer. The rapamycin-G4H nanocapsule can play an efficient antioxidant stress and immune inflammatory regulation function, can improve the intraocular microenvironment of a glaucoma patient, and can inhibit the continuous apoptosis of retinal ganglion cells.
Owner:SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL

A device for preparing plant essential oil nanocapsules

This utility model relates to the field of plant essential oil capsule preparation technology, specifically a plant essential oil nano-microcapsule preparation device, including a stirring chamber. A partition is fixedly installed inside the stirring chamber. A feeding component is fixedly installed on the outer surface of the stirring chamber, and a stirring component is rotatably connected inside the stirring chamber. The stirring component includes a rotating shaft, with a shear head fixedly installed at the lower end of the rotating shaft. Multiple stirring blades are arranged above the partition on the outer side of the rotating shaft. A cleaning component is fixedly installed at the upper end of the stirring chamber. In this utility model, by dividing a stirring chamber into upper and lower spaces, a single rotating shaft drives the stirring blades and shear head to rotate. A single stirring device simultaneously stirs the oil and water phases, reducing the footprint of the stirring device. After preparation, it is convenient to discharge wastewater from the upper space into the lower space for reuse in cleaning, reducing cleaning water consumption and the workload of workers, making it easier to use.
Owner:JIANGSU HANHUI COSMETICS MANUFACTURING CO LTD

Engineering probiotic oral nano-capsule modified by nano-material as well as preparation method and application of engineering probiotic oral nano-capsule

The invention relates to an engineering probiotic oral nano capsule modified by a nano material as well as a preparation method and application of the engineering probiotic oral nano capsule. The engineering modification of probiotics comprises the steps of knocking out a clbA gene and overexpressing an Sj16 protein and a GbpA protein. The intestinal adhesion protein GbpA is expressed on the surface of the engineered escherichia coli, an ultrasonic response element is integrated, the immunomodulatory protein Sj16 can be controllably expressed under ultrasonic stimulation, the adhesion and colonization capacity of the engineered escherichia coli in the intestinal tract is enhanced through engineered modification, the immune balance of the intestinal mucosa is cooperatively regulated, and the immunomodulatory effect of the engineered escherichia coli is improved. The generation and secretion of pathogenic autoantibodies from intestinal tracts are obviously reduced. On the basis, the molybdenum-based monatomic nano-material is functionally modified by using an enteric polymer, and a uniform nano-material-polymer composite coating is formed on the modified probiotics by adopting an in-situ wrapping technology, so that the nano-material-polymer composite coating shows a remarkable effect in the aspect of treating the autoimmune nephritis and has an important clinical application value.
Owner:THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA

Method for high-throughput preparation of tobacco essence microcapsules based on supercritical microchannel

The invention discloses a method for preparing tobacco essence microcapsules based on supercritical microchannel high throughput. According to the method, a microchannel reaction system special for the supercritical anti-solvent process is constructed, a solution of tobacco essence and a wall material and supercritical carbon dioxide are pumped into a microchannel array according to the flow ratio of (15-60): 1, anti-solvent crystallization is carried out under the conditions of 8-15 MPa and 35-55 DEG C, and the microcapsules are obtained through decompression separation. According to the system, a tree-shaped fractal flow channel distributor and at least 64 parallel micro-channels are adopted, and millisecond-level uniform mixing under the supercritical condition is achieved; the inner wall of the micro-channel is subjected to hydrophobic modification (with a contact angle gt and 110 degrees) to prevent blockage; and online monitoring and machine learning intelligent control are combined to form a quality closed loop. According to the method, the problems of wide particle size distribution, low encapsulation efficiency, poor thermal stability and poor production consistency of the nano microcapsules are solved at a time, the average particle size of the prepared microcapsules is 50-300 nm, PDI is smaller than or equal to 0.15, the encapsulation efficiency is larger than or equal to 99.5%, the fragrance carrying rate is larger than or equal to 40%, the microcapsules have excellent thermal stability and slow release performance, and linear amplification of productivity can be achieved.
Owner:PUCUI SUPERCRITICAL (GUANGDONG) HIGH TECH CO LTD