67 results about "Amphiphilic copolymer" patented technology

The invention discloses a composite viscosity reducer and an oil extraction and viscosity reduction process thereof, and belongs to the technical field of petrochemical engineering. The composite viscosity reducer comprises an amphiphilic copolymer, sodium fatty alcohol polyoxyethylene ether sulfonate, modified nano silicon dioxide and water, wherein the composite viscosity reducer is prepared from 0.5 to 5 weight percent of amphiphilic copolymer, 0.05 to 2 weight percent of fatty alcohol polyoxyethylene ether sodium sulfonate, 5 to 15 weight percent of modified nano silicon dioxide and the balance of water. The composite viscosity reducer has good temperature resistance and can adapt to a complex oil reservoir environment, and the composite viscosity reducer can be matched with a hydrodynamic cavitation transducer, so that sodium fatty alcohol polyoxyethylene ether sulfonate can be fully mixed and emulsified with crude oil, the crude oil is heated, and the oil displacement and viscosity reduction effects are further improved.

The invention discloses a method for preparing hydrophilic carbon fiber, belonging to the technical field of carbon fiber materials. Glycidyl methacrylate and methyl methacrylate ethyl sulfobetaine are copolymerized by free radical polymerization to prepare a controllable amphiphilic copolymer; the amphiphilic copolymer is blended with dopamine, and a ternary system polymer is prepared by reacting an epoxy group with an amino group. Under alkaline solution conditions, the adhesion of dopamine after self-polymerization is utilized to introduce hydrophilic zwitterionic groups to the fiber surface to achieve sizing function, and to give the carbon fiber surface hydrophilic properties, so that it has better fiber opening in water, and achieves the effect of complete dispersion under aqueous conditions. The preparation method can ensure the strength of carbon paper while improving the dispersibility of carbon fiber, has important application prospects, and has a simple process and can meet the needs of large-scale industrialization.

The invention relates to an elastic solid electrolyte with a lithium ion selective transmembrane transmission characteristic and a preparation method thereof. The elastic solid electrolyte is composed of a component A, a component B and a component C, wherein the component A comprises 12-35 parts by weight of an amphiphilic copolymer composed of a polar chain segment and a non-polar chain segment, and the weight ratio of the polar chain segment is 5-45%; the component B is 36-60 parts by weight of plastic crystal electrolyte and is formed by dissolving plastic crystals and lithium salt, and the weight ratio of the plastic crystals to the lithium salt is 1: (0.2-0.7); and the component C comprises 20-36 parts by weight of a reactive monomer and a lithium salt, and the weight ratio of the reactive monomer to the lithium salt is 1: (0.2-0.4). The preparation method comprises the following steps: firstly, preparing a fiber network elastic solid electrolyte by virtue of electrostatic spinning induced phase separation, and coating a fibrous continuous plastic crystal B by virtue of an elastomer layer A with lithium ion selective permeability; and performing in-situ polymerization on the component C to realize gap filling to obtain the elastic solid electrolyte. The solid electrolyte not only has very high ionic conductivity, but also has high mechanical strength, and the rate capability and the cycle life of the solid lithium battery are remarkably improved and prolonged.

The invention discloses low-irritation cyhalothrin and a preparation method and application thereof, and belongs to the technical field of pesticide preparations, the low-irritation cyhalothrin comprises silicon dioxide nanoparticles with the surfaces grafted with amphiphilic copolymers, cyhalothrin and an anti-allergic drug, the silicon dioxide nanoparticles with the surfaces grafted with the amphiphilic copolymers are dispersed in a solvent, and the anti-allergic drug is added to the silicon dioxide nanoparticles with the surfaces grafted with the amphiphilic copolymers to prepare the low-irritation cyhalothrin. The preparation method comprises the following steps: taking porous silicon dioxide nanoparticles as a carrier, modifying a layer of amphiphilic polymer on the surface of silicon dioxide in situ, then adding cyhalothrin and an anti-allergic drug, continuously stirring, and drying the obtained product to obtain the low-irritation cyhalothrin. The cyhalothrin and the anti-allergic drug are loaded in silicon dioxide pore channels, and the anti-allergic agent is used in cooperation, so that the skin irritation of the cyhalothrin is reduced. The cyhalothrin with low irritation provided by the invention is simple in preparation method, can be used as a cyhalothrin insecticide raw medicine, and has relatively great market application potential.

The present invention discloses a polyethersulfone membrane with low protein adsorption function and its preparation method. The polyethersulfone membrane comprises the following raw materials according to mass percentage: 10-30% of polyethersulfone, 3-15% of amphiphilic copolymer, 2-10% of pore former, 0.5-15% of non-solvent, and 55-75% of solvent. Through a carefully designed formulation and preparation process, the present invention successfully prepares a polyethersulfone membrane with low protein adsorption function. The addition of the amphiphilic copolymer P(PVP-r-PDMS) not only enhances the hydrophilicity and protein adsorption resistance of the membrane, but also realizes the optimization of the membrane structure through the fine regulation of the RTIPS method. Finally, a polyethersulfone hollow fiber membrane with excellent anti-fouling performance and high permeability is obtained, which has broad application prospects in the fields of hemodialysis, drug filtration, food industry, etc.

The invention discloses a preparation process of rebamipide tablets, and relates to the technical field of pharmaceutical preparations. When preparing rebamipide tablets, the present invention first reacts BOC-lysine tert-butyl ester hydrochloride with isocyanoethyl methacrylate to obtain lysine monomer; lysine monomer is reacted with terminal 2-bromoisobutyrate polylactic acid to obtain an amino acid amphiphilic block copolymer; amino acid amphiphilic block copolymer is used to load rebamipide to obtain a loaded rebamipide amphiphilic copolymer; dopa is reacted with chitosan to obtain dopa-modified chitosan; dopa-modified chitosan and bismuth salt are film-coated on the surface of the loaded rebamipide amphiphilic copolymer to obtain dopa-modified chitosan-coated rebamipide, and then dopa-modified chitosan-coated rebamipide is made into tablets to obtain rebamipide tablets. The rebamipide tablets prepared by the present invention have the advantages of mucosal adhesion, long in vivo retention time, and high cellular uptake.

Provided herein are self-assembled nanoparticles (NPs), pharmaceutical compositions containing such NPs and methods of using such NPs. The NPs comprise an amphiphilic copolymer and a ribonucleoprotein (RNP), and optionally ssODN, wherein: the amphiphilic copolymer is a water-soluble block copolymer comprising a poly(C2-3 alkylene glycol) block and an acrylic block comprising a poly(acrylate), poly(methacrylate) or poly(acrylate / methacrylate) block; the acrylic block comprise ester side chains bearing substituted or unsubstituted alkylamine groups; and the RNP, ssODN, and the acrylic block of the amphiphilic copolymer form a core of the self-assembled nanoparticle, and the poly(ethylene glycol) block of the amphiphilic copolymer forms the exterior of the self-assembled nanoparticle.

The application relates to the technical field of building materials, in particular to an extruded sheet and a preparation method thereof, which comprises the following raw materials in parts by weight: polystyrene resin 60-70 parts, copolymer resin 30-40 parts, foaming agent 5-10 parts, antioxidant 0.5-0.8 parts, zinc stearate 1-2 parts and calcium carbonate 0.2-0.5 parts. The gradient segment design of the amphiphilic copolymer and the sodium alginate-calcium ion crosslinking network are utilized, the compression strength and the bending strength of the prepared extruded sheet are improved, and the extruded sheet has good rigidity and anti-deformation capacity. Meanwhile, the water vapor permeability of the extruded sheet is low, which indicates that the prepared extruded sheet can effectively balance the barrier and air permeability requirements.

The application discloses an anticoagulant biomaterial for blood purification and a preparation method and application thereof, and comprises the following steps: providing an amphiphilic copolymer P(AA-MMA); blending polyethersulfone, P(AA-MMA) and a solvent, stirring at a set temperature to obtain a casting solution, and preparing a blending membrane from the casting solution; soaking the blending membrane in a 2-morpholine-4-yl ethanesulfonic acid buffer solution containing argatroban, 1-ethyl-(3-dimethylaminopropyl) carbonyl diimide and hydroxy succinimide, and reacting at room temperature to obtain an argatroban grafted blending membrane, namely the anticoagulant biomaterial. The method improves the hydrophilicity of the membrane, reduces the albumin adsorption of the membrane, reduces the adhesion of platelets on the membrane, prolongs the coagulation time APTT, PT and TT of the membrane, and is better in biocompatibility and enhanced in anticoagulation performance.

The invention provides a cardiac targeting nano drug delivery carrier based on recombinant apolipoprotein, a system, a preparation method and application. The cardiac targeting nano drug delivery carrier comprises a nano carrier core and a functional layer covalently coupled to the surface of the nano carrier core, the nano carrier core comprises an amphiphilic copolymer formed by polylactic acid-glycolic acid and polyethylene glycol; the functional layer comprises recombinant apolipoprotein A-I and heart targeting peptide; the recombinant apolipoprotein A-I contains mutation sites E191A and F225W, and the recombinant apolipoprotein A-I contains mutation sites F225W; the amino acid sequence of the recombinant apolipoprotein A-I is as shown in SEQ ID NO: 1. The cardiac targeting nano drug delivery system based on the recombinant apolipoprotein has the functions of long circulation, cardiac targeting and coordinated regulation and control of metabolism and inflammation, and can be used for precise treatment of chronic heart failure.

The present invention relates to highly water-absorbent hollow polymer microspheres and their concrete moisturizing and curing membranes. The hollow polymer microspheres are formed by photoinitiated Pickering emulsion polymerization. The Pickering emulsion comprises an emulsifier, water, and an oil phase. The emulsifier is a photopolymerizable amphiphilic copolymer particle, and the oil phase comprises a photocurable monomer and a photoinitiator. Under light, the photopolymerizable amphiphilic copolymer particle and the photocurable monomer undergo separate polymerization reactions to form hollow polymer microspheres having a hydrophilic shell. The shell's strong hydrophilicity allows for rapid absorption of large amounts of water and storage in its internal cavity. Compared to conventional water-absorbent resins, the cavity structure within the hollow polymer microspheres of the present invention significantly increases water storage capacity. The concrete moisturizing and curing membrane prepared using the hollow polymer microspheres of the present invention has extremely strong water retention. The internally absorbed water can be released into the concrete through capillary action on the rough surface of the base fabric layer, ensuring the required moisture for the concrete during its curing period.

The invention relates to the technical field of medicine, and discloses a raltitrexed composition and a preparation method thereof.The raltitrexed composition is prepared by taking a full-biodegradable amphiphilic polymer grafted with hydrophilic chitosan and hydrophobic polylactic acid as a carrier, a raltitrexed drug is embedded in a micelle core of a copolymer by virtue of the large specific surface area and strong adsorption capacity of the carbon nano tube, the targeting function of folic acid and the hydrophobicity of a long chain of polylactic acid under the action of pi-pi action and electrostatic adsorption with the carbon nano tube and chitosan in the composition, so that the encapsulation efficiency is greatly improved; raltitrexed molecules contain elements such as O, N and S, hydrogen bonds can be easily formed by the Raltitrexed molecules and the amphiphilic copolymer, the drug release time can be prolonged through a hydrophobic end polylactic acid side chain, the purpose of slow release is achieved, drug toxicity and adverse reactions are reduced, and the prepared composition is stable in release and ideal in slow release effect.

Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.

The present disclosure pertains to a 3D scaffold for cell growth and proliferation. In particular, the present disclosure provides a method of producing an artificial 3D scaffold to support stem cell growth and later their differentiation, by converting biodegradable amphiphilic copolymers (star polymer) into nanowire scaffolds, through a molecular self-assembly process. The invention also relates to the use of said scaffold for cell culture and / or transplantation.

The invention discloses a waterproof and antifogging coating liquid which comprises hydrophilic resin, an amphiphilic copolymer and a solvent, the hydrophilic resin is obtained by polymerizing a hydrophilic monomer, a hydrophobic monomer, an epoxy monomer and a benzophenone monomer under the action of an initiator; the amphiphilic copolymer is prepared from N, N-dimethylacrylamide serving as a hydrophilic section and diacetone acrylamide serving as a hydrophobic section through an addition-fragmentation chain transfer polymerization method. The hydrophilic resin and the amphiphilic copolymer are compounded, so that the waterproof and antifogging layer with excellent antifogging performance, light transmittance, wear resistance and scratch resistance is obtained, and the durability of the waterproof and antifogging layer is improved; a benzophenone monomer with a benzophenone group is arranged through the hydrophilic resin, so that the adhesive force between the waterproof and antifogging layer and the base material layer is improved.

The application relates to the technical field of medicines, and discloses a composition of raltitrexed and a preparation method thereof. The composition of raltitrexed is a full-biodegradable amphiphilic polymer with hydrophilic chitosan and hydrophobic polylactic acid grafted as a carrier, and the composition is combined with carbon nanotubes and chitosan through pi-pi interaction and electrostatic adsorption. The carbon nanotubes have a large specific surface area and strong adsorption capacity, the folate has a targeting function, and the polylactic acid long chain has hydrophobicity. The raltitrexed drug is embedded in the micelle core of the copolymer, so that the encapsulation rate is greatly improved. The raltitrexed molecule contains O, N, S and other elements, can easily form a hydrogen bond with the amphiphilic copolymer, the hydrophobic end polylactic acid side chain can prolong the drug release time, achieve the purpose of slow release, reduce the drug toxicity and adverse reactions, the prepared composition is relatively stable in release, and the slow release effect is relatively ideal.

The invention discloses a polycaprolactone-based amphiphilic copolymer, which is prepared from mPEG 90, 4-phenyl caprolactone and caprolactone in a molar ratio of 1: (5-50): (2-60) through TBD catalysis. Or, mPEG90 and 4-phenyl caprolactone in a molar ratio of 1: (5-50) are catalyzed by TBD (tetrabutyl disulfide) to prepare the TBD. The polycaprolactone-based amphiphilic copolymer provided by the invention is an amphiphilic polymer, and can be self-assembled into micelles in water for entrapment of an anti-cancer drug adriamycin; compared with mPEG-PCL with the same molecular weight, the polycaprolactone-based amphiphilic copolymer has higher drug loading capacity and stability.

The invention relates to the technical field of materials, in particular to a polysulfone composite material and a preparation method and application thereof, and the polysulfone composite material comprises modified polysulfone, modified rubber particles, an amphiphilic copolymer and hyperbranched polyglycerol. A hydroxyl sulfonate bond is generated through an epoxy group of the modified SEBS and a sulfonic group of the modified polysulfone in the modified rubber particles to reinforce the two-phase binding force, and micro holes are generated around the modified rubber particles under the action of external force to reinforce the anti-falling property of the reusable filtering device, so that the service life is prolonged. The hydrophilic segment of the amphiphilic polymer is compatible with the modified polysulfone, and the hydrophobic segment anchors the modified rubber particles, so that the dispersion of the modified rubber particles in the polysulfone composite material is promoted, the light scattering is reduced, and the transparency of the bottle body is improved. The hyperbranched polyglycerol and the amphiphilic copolymer generate a copolymer-hyperbranched polyglycerol complex, and the steric hindrance of a branched structure is utilized to prevent the modified rubber particles from getting close to each other, so that the dispersion efficiency of the amphiphilic copolymer is remarkably improved.

The invention discloses a high-performance PVC-U ultra-pure pipe and a preparation method thereof. SG-5 type non-plasticized polyvinyl chloride resin is used as a base material; the preparation method comprises the following steps: adding a topological structure type polycaprolactone-polysulfobetaine amphiphilic copolymer, a methyltin mercaptide stabilizer, an acrylate copolymer anti-impact aid, a methyl methacrylate-butadiene-styrene terpolymer processing aid and a lubricant, and carrying out high-speed mixing, twin-screw extrusion, vacuum setting and ultrapure water cleaning processes. The copolymer is entangled and anchored with a polyvinyl chloride chain through a polycaprolactone arm, and a polysulfobetaine arm forms a hydrophilic anti-fouling layer on the inner surface of the pipe. The total organic carbon precipitation amount of the pipe is 0.008-0.012 mg / m < 2 >. D, the inner surface Ra is 0.40-0.50 [mu] m, and the pipe is suitable for conveying semiconductor ultrapure water, resists 0-60 DEG C and effectively resists biological pollution. The performance is stable, and the existing production process requirements are met.

The present application relates to a ginsenoside Rg3 drug delivery system, and a preparation method and application thereof. White yam polysaccharides (BSPs) are extracted from white yam by water extraction and alcohol precipitation, and then subjected to defatting, decolorization, deproteinization and chromatographic purification. A small hydrophobic molecule SA is introduced to modify the structure of BSPs, and a dialysis method is used to prepare BSPs-SA polymer micelles, and an amphiphilic copolymer BSPs-SA is obtained as a carrier material. An emulsion solvent evaporation method is used to prepare G-Rg3@BSPs-SA polymer micelles, and the freeze-dried powder is loaded into a colon-soluble capsule shell to prepare a G-Rg3@BSPs-SA colon-soluble capsule with double targeting. The in vitro drug release behavior and preliminary stability of the capsule are evaluated. After oral administration of the delivery system, no drug is released in the upper gastrointestinal tract, and after entering the colon, the capsule shell is degraded in the specific pH environment of the colon to release G-Rg3@BSPs-SA polymer micelles. Through the dual targeting function on tumor cells and M2-TAMs, the delivery system can achieve multi-link regulation of "inhibiting tumor cell growth and regulating immune microenvironment" of colon cancer, and effectively inhibit the occurrence and development of colon cancer.

Amphiphilic copolymers and compositions including amphiphilic copolymers. The amphiphilic copolymers include modified maleimide subunits, for example, as illustrated by the structures of Formula IA and Formula IB. The compositions form water-soluble complexes upon association with biological material wherein such biological material can include lipids or membrane proteins. Methods for producing, purifying, analyzing, and using the compositions and complexes are provided.

Described herein are flash nanoprecipitation methods capable of encapsulating hydrophobic molecules, hydrophilic molecules, bioactive protein therapeutics, or other target molecules in amphiphilic copolymer nanocarriers.

The invention discloses an amphiphilic copolymer for natural gas hydrate fracturing fluid, a preparation method thereof and use thereof in natural gas hydrate fracturing fluid, wherein the amphiphilic copolymer is a ternary or tetrapolymer formed by polymerization of acrylamide monomer, 2-acrylamide-2-methylpropanesulfonic acid monomer, enol polyether amphiphilic monomer and polyether diunsaturated acid ester monomer, and has a general structural formula (I). The copolymer can well improve the viscoelastic properties of the solution, enhance the anti-shear performance of the solution, and the formed fracturing fluid system has the advantages of strong sand suspension capacity, low transport friction, low formation damage and effective reduction of interfacial tension.

The invention discloses a self-dispersing color lake for a water-based cosmetic material and a preparation process of the self-dispersing color lake. The preparation process comprises the following steps: firstly, carrying out hydrophobic treatment on the surface of the color lake by using a hydrophobic treatment agent to prepare a hydrophobic color lake; then, the lake subjected to hydrophobic treatment and the amphiphilic copolymer are subjected to self-assembly in water, the surface of the lake is subjected to hydrophilic treatment, in the process, a hydrophobic chain segment in the polymer can be spontaneously combined with a hydrophobic group on the surface of the lake, and then a hydrophilic chain segment is spontaneously exposed to the surface of the lake. And finally, preparing the lake capable of self-dispersing in water through a freeze-drying process. According to the method, the double surface treatment technology of the lake is adopted, two plating layers with different properties are constructed on the surface of the lake, the inner hydrophobic layer prevents the lake from making contact with water, the stability of the lake in water is improved, meanwhile, the outermost hydrophilic layer promotes dispersity of the lake in water, and rapid self-dispersion of the lake in water is achieved through the freeze-drying technology.

A polymeric nanocarrier and method of treating a bone disease are provided. The polymeric nanocarrier includes an amphiphilic copolymer including a hydrophobic block and a hydrophilic block, where the hydrophilic block comprises a random copolymer. The method of treating a bone disease includes administering the polymeric nanocarrier to a subject in need thereof.

Particles comprised of a transition metal oxide and an amphiphilic copolymer, having a predetermined particle size, and uses same for encapsulation of hydrophobic compounds and for sono-responsive therapy, are disclosed. The methods of manufacturing the particles with a predetermined particle size are disclosed.

The present invention discloses a nano-micelle composite hydrogel containing green tea essential oil, and a preparation method and application thereof. The nano-micelle composite hydrogel containing green tea essential oil provided by the present invention comprises a hydrogel matrix and an amphiphilic copolymer micelle, wherein the amphiphilic copolymer micelle comprises an amphiphilic brush-type PBMA-DSEA-PNIPAm copolymer and green tea essential oil entrapped therein. The nano-micelle composite hydrogel containing green tea essential oil provided by the present invention has a good anti-aging effect, and the hydrophobic green tea essential oil is encapsulated by the specific core-shell structure of the amphiphilic micelle to improve the interaction between the hydrophobic green tea essential oil and the hydrophilic hydrogel, increase the loading rate and stability of the green tea essential oil in the polymer hydrogel, and enhance the effect of the green tea essential oil, and the copolymer nano-micelles with dual responsiveness to temperature / light stimulation are used to encapsulate the green tea essential oil, and the controlled release of the green tea essential oil can be achieved by controlling the temperature / light.

The invention provides a preparation method of a pH response type oil-water separation membrane. Specifically, the preparation method comprises the following steps: firstly, grafting polystyrene-maleic anhydride with a substance with primary amine and tertiary amine to prepare an amphiphilic copolymer; and then blending with a high-molecular polymer, and preparing the super-hydrophilic / underwater super-oleophobic film by adopting a phase inversion method. The surface of the blended membrane has rich hydrophilic functional groups including carboxyl and tertiary amine, so that the membrane shows good hydrophilicity and underwater super-oleophobic property, efficient oil-water separation is realized, and meanwhile, the tertiary amine and carboxyl on the surface of the membrane can be activated by acid or alkali and have certain pH responsiveness, so that the membrane has a self-cleaning function.

The present disclosure relates to a resin composition containing: a thermoplastic polyurethane (A1) or a thermoplastic polyurethane (A2); and a (meth)acrylic-based copolymer (B), wherein the (meth)acrylic-based copolymer (B) is an amphiphilic copolymer, a difference in a refractive index between the thermoplastic polyurethane (A1) and the (meth)acrylic-based copolymer (B) is 0.018 or less, and the thermoplastic polyurethane (A2) contains a structural unit derived from at least one of an aliphatic isocyanate compound and an alicyclic isocyanate compound.

The present disclosure relates to cleansing compositions and particularly foaming cleansing compositions including one or more surfactants, one or more viscosity increasing agents, one or more emulsifiers, and one or more foam boosting agents. The one or more foam boosting agents includes a superhydrophilic amphiphilic copolymer. The disclosure also relates to the use of such cleansing formulations on human skin.