14 results about "Mixed micelle" patented technology

The invention belongs to the technical field of oily sludge cleaning, and particularly relates to a macromolecular / micromolecular composite surfactant for intensively cleaning oily sludge. A main monomer (such as acrylamide), a hydrophilic monomer (such as 2-acrylamido-2-methylpropanesulfonic acid) and a hydrophobic monomer (such as methacrylic acid long-chain alkyl ester) are mixed, and the macromolecular surfactant is synthesized through free radical polymerization. The specific long-chain structure of the macromolecular surfactant can form larger micelles, colloid and asphaltene can be effectively wrapped, the macromolecular surfactant is compounded with the micromolecular surfactant for use, and mixed micelles with higher solubilizing capacity can be formed, so that the colloid and asphaltene in the high-medium-concentration oily sludge can be efficiently removed, and the high-medium-concentration oily sludge can be effectively removed. Further, the removal rate of total petroleum hydrocarbon is improved. The invention provides a new technology for high-efficiency deep treatment of high-medium-concentration oily sludge.

The application discloses a phenylboronic acid-based zwitterionic surfactant and a preparation method and application thereof, wherein the phenylboronic acid group of the phenylboronic acid-based zwitterionic surfactant includes two isomers, i.e. m BDC n AB or p BDC n AB, and alkyl chain lengths are C 10 alkyl, C 12 alkyl and C 14 alkyl, and a total of six surfactants are abbreviated as BDC n AB. BDC n AB is mixed with dodecyl-dimethyl-1,2-dihydroxypropyl ammonium chloride to prepare a mixed micelle, and an asymmetric spacer group with a dynamic covalent bond combined by a borate ester bond is generated in situ under mild conditions of normal temperature and neutral pH, thereby obtaining a pH-responsive dimer surfactant, and the dimer surfactant has a pH response interval consistent with a drug release condition for treating cancer in a human body, and can be used for preparing a drug-loaded micelle for treating cancer in the human body.

The invention discloses a high-alkali-resistance textile degreaser as well as a preparation method and application thereof, and relates to the technical field of textile pretreatment. The method comprises the following steps: S1, carrying out a neutralization reaction on fatty acid methyl ester sulfonic acid and a mixed alkali solution of sodium hydroxide and alkanolamine, and controlling the pH value of a reaction endpoint to be 6.0-7.5 to obtain a mixed salt of sodium fatty acid methyl ester sulfonic acid and alkanolamine; s2, adding an alkyl polyglucoside aqueous solution into the mixed salt obtained in the step S1 to form mixed micelles; s3, fatty acid ester ethoxylate and a bio-based cosolvent are added into the mixed micelle obtained in the step S2, homogenization treatment is conducted, and homogeneous microemulsion is obtained; and S4, cooling the microemulsion obtained in the step S3, adding a chelating dispersant and water, and uniformly mixing to form the high-alkali-resistance textile degreaser. The textile degreaser prepared through dication modification and micelle recombination has good alkali resistance, excellent low-temperature water solubility and full-bio-based environmental protection characteristics, and is suitable for pretreatment of textiles such as cotton, polyester and the like.

This invention belongs to the field of oily sludge cleaning technology, specifically a macromolecular / small molecule composite surfactant for enhanced cleaning of oily sludge. A macromolecular surfactant is synthesized by mixing a main monomer (such as acrylamide), a hydrophilic monomer (such as 2-acrylamido-2-methylpropanesulfonic acid), and a hydrophobic monomer (such as long-chain alkyl methacrylate) through free radical polymerization. The unique long-chain structure of this macromolecular surfactant can form larger micelles, effectively encapsulating colloids and asphaltenes. When used in combination with a small molecule surfactant, it forms mixed micelles with stronger solubilizing capabilities, achieving highly efficient removal of colloids and asphaltenes from high-to-medium concentration oily sludge, thereby improving the removal rate of total petroleum hydrocarbons. This invention provides a new technology for the efficient and deep treatment of high-to-medium concentration oily sludge.

This invention belongs to the field of traditional Chinese medicine technology and discloses a high-release drug drop pill and its preparation method. In addition to the main drug extract as the core component for efficacy, the high-release drug drop pill contains a water-soluble matrix as the main framework and solid dispersion carrier, a rapid-disintegrating pore-forming agent to accelerate water penetration, sucrose fatty acid esters as surfactants, alkyl glycosides as penetration enhancers, poloxamer as crystal inhibitors, and phospholipid dispersants to accelerate transmembrane transport. These components work synergistically to improve the high-release properties of the drop pill. The multi-component surfactants synergistically form mixed micelles or lipid microparticles, encapsulating the hydrophobic drug within them to form a thermodynamically stable dispersion system, constructing a solid dispersion and achieving amorphous dispersion of drug molecules. The rapid-disintegrating pore-forming agent achieves overall disintegration, avoiding gelation blockage and increasing the contact area between the drug and the dissolution medium, thereby improving the drug release rate.

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an indissolvable drug nano mixed micelle carrier system and a preparation method thereof. The carrier system has high drug loading capacity and high stability, and can avoid degradation of active ingredients caused by long-time placement; the targeting property is high, so that toxicity reduction and synergism are facilitated; meanwhile, the preparation method is simple, convenient and easy to operate, short in process time and high in stability, and continuous production of micelles can be realized.

The invention discloses a preparation process of vitamin K1 injection mixed micelles, which belongs to the technical field of pharmaceutical preparations, and comprises the following preparation steps: under the protection of inert gas, taking part of water for injection, adding glycocholic acid, stirring and dispersing; s2, under the stirring condition, soybean lecithin and vitamin K1 in the prescription dosage are added into the solution obtained in the S2 at the same time, the stirring rotating speed is controlled to be 800-1000 rpm, and stirring is continuously conducted till the solution becomes a uniform and clear micelle solution; supplementing the water for injection to full dose, and adjusting the pH value of the system to 5.5-6.5 by using a sodium hydroxide solution; performing sterile filtration on the liquid medicine obtained in the step S4 through a 0.22 mu m filter membrane; and filling the filtered liquid medicine into a sealed container under the protection of inert gas, and carrying out terminal sterilization. The process parameters are clear and easy to control, key quality control points are clear, the process transfer and amplification process from laboratory test to industrial mass production is stable and reliable, and batch-to-batch consistency is high.

The application discloses a quercetin-eucalyptus oil composition for clearing and protecting lungs, and relates to the technical field of functional food. The composition comprises an active functional component and a three-phase layered targeting delivery system. The active functional component is composed of quercetin 5-20 parts, eucalyptus oil 1-8 parts, bromelain 2-10 parts, dihydromyricetin 10-30 parts, perillaldehyde 1-6 parts, icariin 3-15 parts and ultralow-molecular-weight sodium hyaluronate 1-5 parts in terms of weight fraction. The three-phase layered targeting delivery system comprises three independent embedding units, namely enteric-soluble protective microspheres for wrapping bromelain, nano-mixed micelles for wrapping quercetin, dihydromyricetin and icariin, and slow-release microcapsules for wrapping eucalyptus oil and perillaldehyde. The application solves the problems of component compatibility conflict and component inactivation in traditional compositions by scientifically matching seven active functional components and combining the three-phase layered targeting delivery system, improves the utilization rate of components, can be produced on a large scale, and improves the storage stability of the composition.

This invention relates to the field of environmental engineering technology, specifically to a highly efficient solubilizing surfactant for chlorinated hydrocarbons, its application, and a method for its preparation. The surfactant comprises decaethylene glycol monododecyl ether, Tween 20, and water. This surfactant is used to solubilize chlorinated hydrocarbon organic pollutants in contaminated sites, including soil, groundwater, and surface water. The mixture of decaethylene glycol monododecyl ether and Tween 20 produces mixed micelles, which increases the solubility of chlorinated hydrocarbons in water and significantly reduces the CMC value of the mixed surfactant, effectively reducing the amount of surfactant required and lowering remediation costs. This surfactant exhibits good biodegradability, high solubilizing ability, and low cost, achieving environmental pollution remediation while reducing secondary pollution.

The present invention discloses a quercetin-eucalyptus-oil composition for clearing and protecting the lungs, relating to the technical field of functional foods. The composition comprises active functional components and a three-phase layered targeted-delivery system. The active functional components comprise, in parts by weight, 5-20 parts quercetin, 1-8 parts eucalyptus oil, 2-10 parts bromelain, 10-30 parts dihydromyricetin, 1-6 parts perillaldehyde, 3-15 parts icariin, and 1-5 parts ultra-low-molecular-weight sodium hyaluronate. The three-phase layered targeted-delivery system comprises three independent encapsulation units, namely enteric-protective microspheres encapsulating bromelain, nano mixed micelles encapsulating quercetin, dihydromyricetin, and icariin, and sustained-release microcapsules encapsulating eucalyptus oil and perillaldehyde. By scientifically combining the seven active functional components with the three-phase layered targeted-delivery system and by improving the preparation process, the present invention solves the problems of component incompatibility and easy inactivation in conventional compositions, improves ingredient utilization, enables large-scale production, and enhances the storage stability of the composition.

A hybrid micelle is provided comprising k-casein or a functionally equivalent variant thereof and a plant protein, wherein the plant protein is soluble under basic conditions and insoluble under neutral conditions, and forms a cross-linked micellar network with kappa-casein. The hybrid micelle can be used to prepare a curd and is useful to prepare animal-free food products such as dairy products. A method of preparing the hybrid micelles involves combining the plant protein and the k-casein at a pH that results in solubilization of the proteins, and adjusting the pH of the protein solution to result in dispersion of the proteins into the hybrid micelles.

The embodiment of the invention provides a selection method and system of a surfactant compounding system and a storage medium, and belongs to the technical field of preparation of surfactants. The method comprises the following steps: acquiring first parameters of a compound system, wherein the first parameters comprise critical micelle concentration and saturated adsorption concentration; based on the first parameter of the compound system, determining a second parameter of the compound system, the second parameter including an interaction parameter between molecules of a mixed micelle layer and an interaction parameter between molecules of a mixed adsorption layer; and based on the first parameter and the second parameter of the compound system, selecting a target compound system from the plurality of compound systems. Through the selection method of the surfactant compound system provided by the embodiment of the invention, the surfactant compound system with a synergistic effect, ultralow interfacial tension and excellent temperature resistance can be quickly screened out.

The invention relates to the technical field of feed, in particular to traditional Chinese medicine-based diet balance cat food for nourishing eyes and protecting liver and a preparation method of the traditional Chinese medicine-based diet balance cat food. N-acryloyl of the modified sodium alginate provides carbon-carbon double bonds to react under ultraviolet irradiation to form carbon-carbon single bonds, and meanwhile, a cis-diol structure of the modified sodium alginate and 3-carboxyphenylboronic acid groups of the modified polyvinyl alcohol form boric acid ester bonds, so that a firm and compact barrier layer is jointly constructed; oxygen and moisture are inhibited from slowly permeating the microcapsule wall material during storage; through directional arrangement of polysorbate 80 on an oil-water interface, liquid drops formed by dissolving lutein in emulsified medium-chain triglyceride are fine emulsion drops, the contact area with intestinal juice is increased, and mixed micelles formed by polysorbate 80, bile salt and phospholipid improve the apparent solubility of lutein in the intestinal juice.

The present invention discloses a quercetin-eucalyptus-oil composition for clearing and protecting the lungs, relating to the technical field of functional foods. The composition comprises active functional components and a three-phase layered targeted-delivery system. The active functional components comprise, in parts by weight, 5-20 parts quercetin, 1-8 parts eucalyptus oil, 2-10 parts bromelain, 10-30 parts dihydromyricetin, 1-6 parts perillaldehyde, 3-15 parts icariin, and 1-5 parts ultra-low-molecular-weight sodium hyaluronate. The three-phase layered targeted-delivery system comprises three independent encapsulation units, namely enteric-protective microspheres encapsulating bromelain, nano mixed micelles encapsulating quercetin, dihydromyricetin, and icariin, and sustained-release microcapsules encapsulating eucalyptus oil and perillaldehyde. By scientifically combining the seven active functional components with the three-phase layered targeted-delivery system and by improving the preparation process, the present invention solves the problems of component incompatibility and easy inactivation in conventional compositions, improves ingredient utilization, enables large-scale production, and enhances the storage stability of the composition.