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178 results about "Hyperoside" patented technology
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Hyperoside is a chemical compound. It is the 3-O-galactoside of quercetin.
Hyperin extraction method and preparation and use thereof
InactiveCN101386634AMeet the requirements of different dosage formsGuarantee product qualityOrganic active ingredientsSugar derivativesFreeze-dryingSolvent
A method for extracting hyperin comprises the following steps: a crude product of an extracting solution of a maniod eibish flower is obtained through extracting the concentrated solution of a maniod eibish flow ethanol extracting solution by normal butanol or ethyl acetate or through the column chromatography of an HPD100 or HPD600 macroscopic absorbent resin; and then hyperin with the content of between 90 and 98 percent in weight percentage is obtained through purification and recrystallization by using a solvent. Hyperin preparations comprise freeze-dried powder injection, liquid drugs injection, transfusions, dropped pills, tablets, capsules, or soft capsules prepared by using hyperin as an active component and pharmaceutical adjuvant. The hyperin is used for preparing the medicines for treating cerebral ischemia.
Owner:周春晓 +1
Preparation method of hyperin and hypericin of Hypericum perforatum
InactiveCN1880328AHigh yieldReduce manufacturing costOrganic active ingredientsSenses disorderHypericum perforatumHyperoside
This invention relates to a method for producing Hypericum perforatum hyperoside and hypericin. This invention comprehensively utilizes Hypericum perforatum fruits which are rich in our country to produce both hyperoside and hypericin pharmaceutical active components with high recovery rate, high product purity, and low cost. During the producing process, it achieves the recovery and cycling use of many solvents like ethanol and ethyl ether, and also achieves the regeneration and cycling use of micelle reextracting agent and absorption resin. The plant biological active compounds produced by this invention can be broadly used in heat-clearing and detoxifying, astringing to arrest bleeding and promote diuresis, and antidepressant drug.
Owner:CHONGQING UNIV
Apocynum extract and extracting method thereof
InactiveCN1634325ARetain pharmacological activityImprove use valueNervous disorderMetabolism disorderHyperosideHydrolysis
The invention relates toa an Apocynum extract and extracting method, which consists of, (1) determining the extract with hyperin as the representing composition, the content of flavones in the extract is 35-90%, (2) after the complete hydrolysis of the extract, the content of meletin compound is 30-80%, (3) the content of hyperin in the extract is 15-55%.
Owner:李青山
Method for extracting chlorogenic acid and hyperoside from lonicera japonica leaves
InactiveCN102816066AAvoid dependenceHigh yieldSugar derivativesCarboxylic acid esters separation/purificationPurification methodsChlorogenic acid
In order to make full use of local resources, also reduce extraction and purification equipment investment, effectively improve the yield of chlorogenic acid and hyperoside from lonicera japonica leaves, shorten the production time from collection till obtaining of the high content chlorogenic acid and hyperoside, as well as reduce the production costs of chlorogenic acid and hyperoside, the invention provides a purification method for extracting chlorogenic acid and hyperoside from fresh lonicera japonica leaves. The method employs enzyme deactivation treatment, hydrochloric acid extraction, filtration, extraction, macroporous adsorption resin chromatography, and crystallization so as to obtain pure chlorogenic acid and hyperoside products. The whole separation process has no high requirements for environmental conditions, the separation time is short, and the purity is high. Separation materials are easily available and cheap, and the separation operation process is simple and is easy to control. Crystallization and recrystallization are adopted. The purification efficiency is high, environmental pollution is reduced, and resources are also saved.
Owner:JISHOU UNIVERSITY
Maniod ebish flower extract, extraction and analysis method and extract preparation and use thereof
InactiveCN101385748AGood treatment effectNotable mechanism of actionPill deliveryCapsule deliveryDiseaseAdditive ingredient
An extract from Sunset Abelmoschus, containing 50-75wt% of total flavone counted by hyperin, wherein, the contents of hyperin, isoquercitrin and quercetin-3'-glucoside are 10.0-15.0wt%, 7.0-12.0wt% and 8.0-12.0wt% respectively, and a total flavone finger-print is provided. The extract is obtained by the following steps: a concentrated solution of a Sunset Abelmoschus ethanol extract undergoes chromatography through an HPD400 or HPD700 macroporous absorbent resin column to derive a crude extract or is extracted by normal butanol to derive the crude extract; a refined extract is obtained by refluxing extraction with ethyl acetate-ethanol azeotropic mixture or ethyl acetate-methanol mixture; the refined extract goes through pressure reducing exsolution and drying. Corresponding contents and a method for detecting finger-print are also provided. The extract preparation is a dripping pill, tablet, capsule or soft capsule obtained through processing with the extract as an active ingredient and pharmaceutical excipients. The extract can be used for preparing a medicine preparation for treating cardiac anencephalohemia diseases.
Owner:周春晓 +1
Application of the effective part of Chinese medicinal material lindley eupatorium herb in preparing antiviral medicine
Lindley eupatorium herb total flavone and its pharmaceutically acceptable salt is used in preparing medicine for preventing and treating virus diseases, especially SARS. Lindley eupatorium herb total flavone is selected from quercetin, kaempferol, jaceidin, hyperoside, trifolirhizin, astragaloside or their mixture. Lindley eupatorium herb total flavone in the concentration of 100 microgram / ml has no toxicity to VeroE6 cell and complete supperssion on SARS virus.
Owner:JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
Method for preparing hyperin and isorhamnetin-3-0-galactose glycosides reference substance simultaneously
InactiveCN1523032AStable storageNo change in contentSugar derivativesSugar derivatives preparationAcetic acidGlycoside formation
The present invention discloses a method for simultaneously preparing hyperin and isorhammetin-3-O-galactoside control products. Said method includes the following steps: (1) placing Chinese medicinal material evodia in a container, adding solvent to make extraction with reflux; (2) filtering evodia extract, reduced pressure concentrating to obtain extractum, adding water to dissolve it, then successively using petroleum ether, chloroform and ethyl acetate to make extraction; (3). using column chromatographic process to purify the ethyl acetate extracted portion twice; and (4). combining chromatographic eluents, concentrating, recrystallizing so as to obtain the invented two control products of hyperin and isorhamnetin-3-O-galactoside. Said invention is simple, and can simultaneously prepare hyperin and isorhamnetin-3-O-galactoside pure products whose purity can be above 98%.
Owner:ZHEJIANG UNIV
Method for preparing hyperoside and isoquercitrin simultaneously from dogbane leaves
ActiveCN102924537ALarge amount of processingIncrease profitSugar derivativesSugar derivatives preparationDissolutionSilica gel
The method relates to a method for preparing hyperoside and isoquercitrin simultaneously from dogbane leaves. The method includes subjecting the dogbane leaves which serve as a raw material to heating reflux or ultrasonic extraction, and obtaining an extract after decompressing concentration; adding water to the extract for dissolution, and removing pigment and fat soluble impurities through petroleum ether; performing aqueous phase dilution, preforming dynamic adsorption until saturation through at least three serially connected macroporous adsorption resin columns, feeding an eluting solution for elution, then performing elution through the eluting solution until no hyperoside and isoquercitrin flowing out, and collecting the effluent liquid; and performing compressing concentration on the effluent liquid, performing recrystallization in methanol, enabling the liquid to pass through a medium-pressure gradient eluting system filled with C18 reverse phase silica gel, and obtaining the hyperoside and the isoquercitrin simultaneously whose purities reach 90%-98%. According to the method, the sample throughput is large, the operation is simple, high-purity hyperoside and isoquercitrin are prepared simultaneously, and not only the cost is low, but also the method is suitable for large-scale preparation.
Owner:YANTAI INST OF COASTAL ZONE RES CHINESE ACAD OF SCI
Extraction method of hyperin and application thereof in medicament preparation
ActiveCN101891785AEasy to solveGood treatment effectOrganic active ingredientsSugar derivativesHypericum perforatumTurpinia formosana
The invention relates to an extraction method of hyperin and application thereof in medicament preparation. The extraction method of the hyperin comprises the following steps: placing Turpinia formosana leaves or Hypericum perforatum in 30%-90% ethanol of 5-15 times, carrying out reflux extraction for 1-3 times, and filtering, wherein the reflux extraction of each time is carried out for 1-3 hours; merging the filtrates, recovering the ethanol, eluting the aqueous solution with a macroporous adsorption resin column, collecting eluted parts, carrying out depressurized concentration, and drying to obtain mixed total glycoside of the hyperin; and carrying silicagel column chromatography and Sephadex LH-20 column chromatography separation, merging hyperin fractions, and crystallizing to obtain the pure hyperin product. The hyperin can be used as a neuraminidase inhibitor for preventing and treating flu, and can be prepared into pharmaceutically acceptable dosage forms.
Owner:JIANGXI SHANXIANG PHARMA +1
Method for preparing hyperin from Dogbane leaves
InactiveCN102190693AHigh purityReduce consumptionSugar derivativesSugar derivatives preparationSolventHyperoside
The invention discloses a method for preparing hyperin from Dogbane leaves, which comprises the following steps: firstly. determining the optimum extraction temperature, a separation material and the concentration of an eluting agent; secondly, regulating the pH value, and extracting with a solvent having high hyperin dissolving and extracting power, thus obtaining a liquid extract; thirdly, heating at 80-85 DEG C under reflux of ethanol or methanol, and extracting; and finally, standing and crystallizing at a preferable cooling temperature, thus effectively separating the hyperin and isoquercitrin which are two flavonoid glycoside components having similar properties. In the invention, the hyperin is further purified by preparing a liquid phase; and a moving phase is examined and determined by methodology, and is subjected to targeted and efficient separation and purification based on the absorption wavelength of the hyperin, thus obtaining the hyperin having purity up to 90-99%. Thehyperin conforms to the requirements for Class A active pharmaceutical ingredients.
Owner:JIANGSU PROVINCIAL HOSPITAL OF TCM
Quality detection method of five-flavor manna medicine bath preparation
ActiveCN102707007ARaise quality standardsQuality is easy to controlComponent separationSilanesPseudoephedrine Hydrochloride
The invention discloses a quality detection method of a five-flavor manna medicine bath preparation. The five-flavor manna medicine bath preparation is made from raw materials of Juniperus formosana, ephedra, rhododendron anthopogonoide, myricaria and artemisia sieversiana according to a conventional method of pharmaceutics. On the basis of the primary standard, the thin layer chromatography of ephedra and rhododendron anthopogonoide is revised, the thin layer chromatography of Juniperus formosana and artemisia sieversiana is added. Under the simple and convenient condition of mobile phase, octyl silane bonding silica gel or phenyl bonding silica gel is used as filler, and simultaneously, the contents of ephedrine hydrochloride and pseudoephedrine hydrochloride in the ephedra are detected. The invention also provides a method for measuring the content of hyperoside in five-flavor manna preparation rhododendron anthopogonoide, thus ensuring the safety, effectiveness and controllability of product quality. By the quality detection method, the quality standard of the existing five-flavor manna medicine bath preparation is improved correspondingly.
Owner:JINHE TIBETAN MEDICINE
Method for preparing hyperoside and isoquercetin from cotton petal
The invention relates to a preparation method for hyperin and isoquercitrin, wherein, the method uses cotton petals as materials and an organic solvent for extraction, and an extracting solution is decompressed and condensed to the extract extractum which is dissolved in proper amount of a water solution, and the column chromatography taking macroporous resins as carriers is made, and the column bed is washed by water until the column bed is colorless, and the column bed is eluted by an ethanol solution, and the eluent is collected and condensed so as to obtain coarse products of the hyperin and isoquercitrin, and purified products of the hyperin and isoquercitrin are obtained by the silica gel or C18 silica gel chromatography of coarse products. The method is low in cost and simple in operation, and provides a new path for acquiring the hyperin and isoquercitrin.
Owner:XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI
Extract of dogbane leaf with finger print and preparation and analytical method thereof
InactiveCN101357147AEasy to operateEase of industrial productionColor/spectral properties measurementsPlant ingredientsHyperosideEthyl acetate
A dogbane leaf extract with a fingerprint contains 50-60% of the total flavone based on hyperoside, wherein, the content of the hyperoside is 10-17%, the content of isoquercitrin is 10-16%, the contents of the isoquercitrin and kaempferol are respectively 25-35% and 3.5-4.5% after hydrolysis, the content of proanthocyanidin is 15-25%, and the extract has a definite fingerprint of the total flavone. The preparation method adopts low-polar or middle-polar macroporous absorbent resin to prepare a crude product of the extract from a concentrated solution of an extracting solution of the dogbane leaf extract, the content of the total flavone in the crude product is 40-44%, and the extract with the definite fingerprint is obtained by refining the crude product with the mixture of ethanol and ethyl acetate, and a corresponding analysis method, especially an assay method for the proanthocyanidin, is established. The extract meets the standard requirements of five oral bulk drugs, and the preparation method of the extract is convenient in operation and available in industrialization.
Owner:周亚球 +1
Method for preparing total flavone extract of many prickle acanthopanax
The present invention relates to a manyprickle acanthopanax leaf total flavone extract preparation method. Said preparation method includes the following steps: using manyprickle acanthopanax leaf as raw material, removing impurity, cutting, adding ethyl alcohol to make reflux extraction in extraction tank for 2-4 times, every time is 1-3 hr, combining extracts, concentrating, filtering, adding the filtrate into polyamide column, using water to make elution, then using ethyl alcohol to make elution, recovering ethyl alcohol, concentrating and spray-drying so as to obtain the manyprickle acanthopanax leaf total flavone extract whose total flavone content is 50%-99%.
Owner:CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
High performance liquid chromatography (HPLC) method for detecting contents of flavonoid components in herba houttuyniae
InactiveCN107860848AImprove quality controlReliable methodComponent separationHplc methodPhosphoric acid
Owner:CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE +1
Method for constructing Bidens parviflor willd medicinal material capillary electrophoresis fingerprint and application thereof
InactiveCN101890066AImprove the quality evaluation systemOvercome costsComponent separationDigestive systemHplc fingerprintReference product
The invention provides a method for constructing a Bidens parviflor willd medicinal material capillary electrophoresis fingerprint and an application thereof. The construction method comprises the steps of preparing a test sample solution, preparing a reference solution and analyzing capillary electrophoresis, wherein the reference product is one or more of salicylic acid, rutin or hyperin. The invention radicates the construction method of the Bidens parviflor willd medicinal material fingerprint, can obtain the Bidens parviflor willd medicinal material fingerprint by the method, improve the quality evaluation system of the Bidens parviflor willd medicinal material, overcome the defects of damaged chromatographic columns, large used amount of toxic organic solvents, high analysis cost and polluted environment in the HPLC fingerprint, and provide theory and practice basis for the Bidens parviflor willd medicinal material and overall and effective quality control of crude slices thereof.
Owner:深圳市药品检验所
Epimedium source galactosyl transferase and application of epimedium source galactosyl transferase to preparation of hyperoside
The invention discloses epimedium source galactosyl transferase and an application of the epimedium source galactosyl transferase to the preparation of hyperoside, and belongs to the technical field of gene engineering and biological medicines. The invention provides galactosyl transferase and an application of recombinant saccharomyces cerevisiae expressing the galactosyl transferase to the catalytic synthesis of flavonoid compounds. The constructed recombinant saccharomyces cerevisiae can be enabled to catalyze the transfer of UDP-galactose to various flavone substrates such as quercetin, kaempferol, myricetin, dihydroquercetin, dihydrokaempferol, dihydromyricetin, fisetin, morin and icaritin.
Owner:JIANGNAN UNIV
Detection method for flavonoids compounds in cotton rose general flavone
ActiveCN102012405AHigh precisionGood reproducibilityComponent separationPlant ingredientsWavelengthHyperoside
The invention discloses a detection method for flavonoids compounds in cotton rose general flavones. In the method, a high performance liquid chromatograph and an ultraviolet detector are adopted; the determination is carried out according to the D high performance liquid chromatography of the appendix VI of volume I of Chinese pharmacopoeia, 2005 edition; octadecylsilane chemically bonded silica is used as the filler: XBridge Shield RP18, 4.6mm*250mm, and 5mu m; a specific mobile phase is adopted; the detection wavelength is 370nm or 254nm; the sample size is 20mu L; the theoretical plate number calculated according to quercitrin is not less than 3000; and the prepared test article solution and reference substance solution are injected under the chromatograph detection condition and are detected by a high performance liquid chromatograph. The method can work out the content of the quercitrin in the general flavones according to the peak area of the quercitrin and qualitatively detects out rutin and hyperin according to the appearance time of each peak of the test article solution.
Owner:陕西汉唐制药有限公司
Use of hyperoside in preparation of drug for inhibiting bacterial quorum sensing system
InactiveCN104367586AWide variety of sourcesReduce pathogenicityAntibacterial agentsOrganic active ingredientsSignalling moleculesPathogenicity
The invention discloses a use of hyperoside in preparation of a drug for inhibiting a bacterial quorum sensing system. Hyperoside can inhibit a quorum sensing signal molecule thereby reducing bacterial biomembrane formation and virulence factor pathogenicity and reducing bacterial swarming motility so that bacterial resistance to drugs and bacterial pathogenicity are reduced. The hyperoside has low toxicity and use safety.
Owner:THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
Acute turpinia leaf general flavone ethanol reflux extract, and preparation method and application thereof
ActiveCN101862357AInhibit entryInhibition of replicationAntiviralsUrinary disorderFiltrationHyperoside
The invention relates to an acute turpinia leaf general flavone ethanol reflux extract, which is prepared from acute turpinia leaves through ethanol reflux extraction, wherein an extraction method comprises the following steps: taking acute turpinia leaves; adding 30 to 90 percent of ethanol accounting for 5 to 15 times of the volume for carrying out reflux extraction for 1 to 3 times, wherein each time of reflux extraction lasts for 1 to 3 hours; carrying out filtration; merging filter liquid; recovering the ethanol from the filter liquid; using nonpolar macroporous absorbent resin for absorbing water solution; using the ethanol lower than 20 percent for elution to remove impurities; then, using 25 to 90 percent of ethanol for elution; collecting elution liquid; recovering the ethanol; and carrying out concentration and drying to obtain the acute turpinia leaf general flavone ethanol reflux extract. The general flavone content is higher than 50 percent, and the flavone type major chemical ingredients are one kind or several kinds of materials in nuezhenoside, rhoifolin, hyperin, meletin, cyanidenon, apiolin and glucoside or aglycon thereof. The extract can be used as a neuraminidase inhibitor to be used for preventing and treating flu, and can be made into pharmaceutically acceptable preparations.
Owner:JIANGXI SHANXIANG PHARMA
Method for separating and purifying hyperoside and isoquercitroside from aurea helianthus
ActiveCN107759648AReduce consumptionSimplified processing stepsSugar derivativesOrganic chemistry methodsHyperosideZinc salts
The invention relates to a method for separating and purifying hyperoside and isoquercitroside from aurea helianthus, belonging to the field of extraction and separation of natural compounds. The method comprises the following steps: heating, refluxing, and extracting flavones in the aurea helianthus; under alkaline condition, forming stable complex precipitate by zinc salt with flavonoids exceptthe hyperoside and isoquercitroside in the aurea helianthus; centrifuging to remove the complex precipitate; and concentrating supernatant, thus obtaining high-purity hyperoside and isoquercitroside.The method provided by the invention can be used for rapidly, efficiently and safely separating and purifying the hyperoside and isoquercitroside from the aurea helianthus and is beneficial to realization of industrial production of the hyperoside and isoquercitroside.
Owner:BEIJING INSTITUTE OF TECHNOLOGYGY
Quality detecting method for Radix-Acanthopanacis-leaf total flavone extract frozen dry powder injecta
InactiveCN1850138AQuality improvementQuality is safe and reliablePowder deliveryComponent separationAdditive ingredientFreeze-drying
The present invention relates to a quality detection method of acanthopanax leaf total flavone extract freeze-dried powder injection. Said method includes the following several steps: using thin-layer chromatography to make identification, total flavone content and hyperin content determination and total flavone and monomer flavone content detection. Said method can ensure stable quality of said acanthopanax leaf total flavone extract freeze-dried powder injection.
Owner:CHANGZHOU INST OF ENERGY STORAGE MATERIALS &DEVICES
Medicinal wine for preventing and treating cardio-cerebral vascular diseases
InactiveCN1748750AIncrease excitement and sobrietyHigh activityAlcoholic beverage preparationCardiovascular disorderErythrocyte membraneBetaine
The medicinal wine for preventing and treating cardiac and cerebral vascular diseases is prepared with notoginseng, schisandra, haw, wolfberry fruit, safflower and white spirit in 40-60 % alcohol content in certain weight proportion. The medicinal wine contains wintercherry red essence, safflower red essence, carthamin, hyperoside, rutin, betaine, polysaccharide, coarse fat, coarse protein, vitamins, trace elements, etc. It has the functions of tonifying heart, resisting myocardial ischemia and myocardial infaction, resisting anoxia, dredging blood vessel, improving micro circulation, etc. and thus may be used in preventing and treating cardiac and cerebral vascular diseases.
Owner:董亚光
Total giamt St.John' swort Herb flavone extract, its preparing method and use
InactiveCN1821255ASignificant anti-ischemic effectGood curative effectPowder deliverySugar derivativesVascular diseaseTraditional medicine
The present invention features that the extract has total flavone content of 50-90 wt%, and the total flavone consists of rutin 5.0-15.0 wt%, hyperoside 8.0-25.0 wt%, isoquercitrin 10.0-30.0 wt%, quercetin 2.0-7.0 wt% and kaempferol swartziol 0.8-2.5 wt% except other flavone components. The extract may be used in preparing medicine for treating cardiac and cerebral vascular diseases.
Owner:周亚球 +1
Human seminal fluid cryoprotectant with Chinese medicine monomer
InactiveCN104255703AConducive to preservationImprove performanceDead animal preservationInternational marketHyperoside
The invention provides a human seminal fluid cryoprotectant with a Chinese medicine monomer. The cryoprotectant comprises the Chinese medicine monomer and a human seminal fluid basic cryoprotectant, wherein the Chinese medicine monomer is hyperoside or icariin. By adding the traditional Chinese monomer hyperoside or icariin into the conventional basic seminal fluid cryoprotectant and screening the proportional relation of the Chinese medicine monomer and the basic seminal fluid cryoprotectant, so that the human seminal fluid cryoprotectant with an excellent performance can be prepared, and an excellent seminal fluid preservation effect can be achieved by matching a rapid freezing and rapid thawing method; meanwhile, a novel way is developed for the application of the Chinese medicine monomer in the seminal fluid cryoprotectant, not only can the situation that the preservation effect of sperms can be effectively improved by adding the Chinese medicine monomer in the seminal fluid cryoprotectant be proved, but also a complete freezing system which is likely to accept by the international market and suitable for the people with weak sperms can be established, and the difficulty for freezing the weak sperms can be solved.
Owner:JIANGSU PROVINCIAL HOSPITAL OF TCM
Semen cuscutae extract as well as preparation method and semen cuscutae formula granules thereof
ActiveCN103933104AReduce viscositySolve the problem of low extraction rate of active ingredientsGranular deliveryPlant ingredientsPectinaseCellulose
The invention discloses semen cuscutae extract as well as a preparation method and semen cuscutae formula granules thereof. The preparation method of the semen cuscutae extract comprises the following steps of: preparing semen cuscutae, adding water with pH regulated to 3-4 by using glacial acetic acid, adding 0.5wt%-1.5wt% (based on weight of the semen cuscutae) of cellulose and / or pectinase to carry out enzymolysis, extracting with water and filtering to obtain filtrate; concentrating the filtrate under reduced pressure until clear paste is obtained, and drying. A great deal of experiments and researches of the inventor proves that the preparation method disclosed by the invention has the advantages that the enzymolysis technology is adopted to damage seed coat structure of the semen cuscutae and lower viscidity of seed coat surface after water is added to the semen cuscutae; the optimal parameters in enzymolysis and extraction processes are determined, so that extraction rate of hyperoside and total flavonoids is remarkably improved, and therefore, a problem that extraction rate of active ingredients of the semen cuscutae is low is solved. And the method is simple and easy to operate, and suitable for large-scale production.
Owner:GUANGDONG SECOND PROVINCIAL TRADITIONAL CHINESE MEDICINE HOSPITAL
Dahurian rhododendron leaf extract and extracting method thereof
InactiveCN1634324ARetain pharmacological activityImprove use valueUnknown materialsRespiratory disorderClearing AgentHyperoside
The invention relates to the extracting process for Dahurian rhododendron leaf extract and extracting method, wherein the extract comprises, flavones 30-90% (measured by using hyperin as the representing compostion), hyperin compound 6.3-42%, farrerol 0.4-8%, quercetin compound 0.7-7%, the extraction method comprises employing polyamide resin separating column, clarifying the liquid with clearing agent and purifying.
Owner:李青山
Method for transforming hyperin into quercetin by enzyme reaction
InactiveCN102453736AImprove pharmacological activityEasy to processFermentationReaction temperatureHyperoside
The invention relates to a method for transforming hyperin into quercetin by using a biological enzyme reaction to improve the biological activity of the hyperin. According to the method, a reaction is performed in an ethanol aqueous solution with the concentration of 30-70% under an effect of naringinase, the reaction temperature is 40-70 DEG C, the reaction time is 1-30 hours, and the glycosyl on the hyperin hydroxyl is cut, such that the hyperin is transformed into the quercetin with the high pharmacological activity. With the present invention, the workability of the hyperin is further improved, and the practical application range of the hyperin is expanded.
Owner:许明淑 +2
Method for determining content of three flavone components in kidney-tonifying and toxin-drawing granule
The invention relates to a method for determining the content of three flavone components in a kidney-tonifying and toxin-drawing granule, that is a method for determining the content of puerarin, hyperoside and icariin. The method is characterized in that four ratio change gradient elution is carried out with acetonitrile as a phase A and methanol-0.1% phosphoric acid (1:30) as a phase B, and theflow velocity is 1.0 mL / min; the column temperature is 40 DEG C; and the detection wavelength is 263 nm. The puerarin content, the hyperoside and the icariin content of the kidney-tonifying and toxin-drawing granule are simultaneously determined. The wave peak retention time of the puerarin is 9.5 min, the wave peak retention time of the hyperoside is 15.5 min, the wave peak retention time of theicariin is 28.5 min, the peak appearance of the three components is finished within 30 min, and all wave peaks are well separated. The method has the advantages of simplicity, fastness, high efficiency, low cost, and easiness in promotion and knowing.
Owner:石家庄平安医院有限公司
Composition Comprising Ligustroflavone, Rhoifolin and Hyperin and Its Pharmaceutical Application
ActiveUS20130131000A1Inhibition of replicationReduce generationBiocideDispersion deliveryLigustroflavoneHyperoside
Disclosed is a composition comprising ligustroflavone, rhoifolin and hyperin, which is prepared according to rational weight ratio: 40% to 80% ligustroflavone, 5% to 45% rhoifolin and 1% to 40% hyperin. The composition can be used as a neuraminidase inhibitor for preventing and treating influenza, and can be formulated into pharmaceutically acceptable dosage forms.
Owner:JIANGZI QINGFENG PHARMACEUTICALS INC
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