The medicinal wine for preventing and treating cardiac and cerebral vascular diseases is prepared with notoginseng, schisandra, haw, wolfberry fruit, safflower and white spirit in 40-60 % alcohol content in certain weight proportion. The medicinal wine contains wintercherry red essence, safflower red essence, carthamin, hyperoside, rutin, betaine, polysaccharide, coarse fat, coarse protein, vitamins, trace elements, etc. It has the functions of tonifying heart, resisting myocardial ischemia and myocardial infaction, resisting anoxia, dredging blood vessel, improving micro circulation, etc. and thus may be used in preventing and treating cardiac and cerebral vascular diseases.