1173 results about "Pharmaceutics" patented technology

The present invention relates to whey protein micelles, particularly to whey protein micelle concentrates or powders thereof and to a method for producing them. The present invention also pertains to the use of these micelles concentrates or powders thereof in nutrition and/or cosmetics and/or pharmaceutics.

invention discloses a kit for a serum micro-ribonucleic acid and the application in the early diagnosing of hepatitis B thereof which belong to the technical field of biotechnological pharmaceutics. The invention provides the combination of the micro-ribonucleic acid used for estimating the physiological and/or pathological states of a normal person, a HBVer and a patient with hepatitis B; the combination comprises all the micro-ribonucleic acids which have differential expression in the serum/plasm of the normal person, the HBVer and the patient with hepatitis B and prepares a diagnosing kit which can be used for the early diagnosing of hepatitis B. The combination and the method can be used for the early detection and nondirective therapy of hepatitis B; besides, the combination and the method have the advantages of high specificity, high efficiency, high sensitivity, low detection cost, convenient material obtaining, and the like. Besides, the samples are easily stored.

The present invention relates to a process of producing Maillard flavour preparation, such as process flavours, comprising heating a combination of a carbohydrate source and a nitrogen source in a continuous liquid phase containing at least 10 wt % of an α-hydroxycarboxylic acid component selected from tne group of α-hydroxycarboxylic acids according to the following formula (I): R¹—CR²(OH)—COOH salts of these acids and combinations thereof. It was found that the flavour preparations so obtained exhibit unique flavour profiles, making them particularly suitable for use in foodstuffs, beverages, pharmaceutics, tobacco products and oral care products.

The invention discloses a traditional Chinese medicine composition for treating respiratory tract haze disoperation and a preparation method, the composition comprises the following bulk drugs by weight: 10-30 g of balloonflower root, 1-15g of Zhejiang fritillaria bulb, 1-15g of grosvenor momordica fruit and 1-15g of licorice. The traditional Chinese medicine composition has the efficacy of dispersing lung Qi, lifting airway self-cleaning capability and eliminating harmful substances, in vitro and clinical verifies that the traditional Chinese medicine composition has the accurate curative effect for preventing and treating respiratory tract haze disoperation without toxic and side-effect. The above materials are ground to crude powder and packed in a tea bag, and brewed by boiled water, or water is used for immersing the bulk drugs for 20 minutes, the water decoction is carried out for 15 minutes, the above materials are filtered for drinking as tea, and auxiliary materials and a corrigent are cooperated, an oral liquid, a syrup, a capsule, a particulate agent, a tablet and effervescence particles which can be accepted on pharmacy are prepared directly or indirectly through conventional procedures, and the traditional Chinese medicine composition can be clinically used for treating or preventing the respiratory tract diseases caused by the haze disoperation.

The invention relates to a disposable packaging item capable of being sterilised and/or depyrogenated. The invention in particular relates to the packaging of products and/or devices in the fields of medicine, pharmaceutics, chemistry, biology, food or electronics. The invention in particular relates to a disposable packaging item (1) at least partially produced with at least one thermoplastic film (10) that can withstand sterilisation and/or depyrogenation, said disposable packaging item (1) defining at least one inner enclosure (5) for receiving one or more elements (50) to be packaged, said inner enclosure (5) being under vacuum (40) and preferably sterile and/or depyrogenated, said packaging item (1) including one or more packaged elements (50).

The invention relates to the pharmaceutical application of a medicament combination containing oil of zedoary turmeric. The medicament combination has new pharmaceutical application for preventing and treating various diseases, such as various HPV virus subtype infections, intraepithelial lesion(isl), papilloma and cervical carcinoma, and the like, in particular to high-risk HPV subtype infections. The medicament is prepared into various conventional formulations in the category of pharmaceutics, and the medicament combination can significantly prevent and treat multiple related diseases of HPV infection by clinical verification.

The invention relates to a tadalafil orally disintegrating tablet and a preparation method thereof. Aiming to improve the deficiency of existing tadalafil oral dosage forms, the invention provides the tadalafil orally disintegrating tablet which is convenient to take, is quick in absorption, takes effect quickly and has high bioavailability for doctors and patients to help the patients achieve requirements for natural and satisfactory sexual lives. The tadalafil orally disintegrating tablet takes tadalafil or medicinal salts thereof as an active ingredient, contains pharmaceutically acceptable auxiliary materials such as filling agents, disintegrating agents, flavouring agents and lubricating agents, and when being taken, dispenses with water, can be quickly disintegrated or dissolved in oral cavities only in a few seconds and is ingested along with saliva.

The present invention is a kind of bupleurum root extract and its extracting process and medicinal use, and belongs to the field of Chinese medicine technology. The bupleurum root extract is obtained through extracting bupleurum root with alcohol solution, and contains bupleurum saponin-a in 20-30 wt% and bupleurum saponin-d in 10-20 wt%. The preparation process includes crushing bupleurum root, extraction, concentration, column chromatography, eliminating saccharide, depurating, eluting, decolorizing, concentrating, drying and other steps. The extract has high effective component content, high purity, and excellent medicinal application for resisting inflammation, resisting virus, resisting tumor, regulating incretion, etc.

The invention relates to the fields of high polymer chemistry and pharmaceutical preparation and in particular relates to preparation of a multifunctional linear-dendritic segmented copolymer and application in pharmaceutics thereof. The multifunctional linear-dendritic segmented copolymer has the amphipathy, indissolvable drugs can be obviously dissolved, the drug stability and the in-vivo bioavailability are improved, particularly indissolvable or water-soluble drugs can be coated, and the drugs are self-assembled to form nano-micelle. The modified polyamidoamine structure has the charge inversion property of environmental response, so that the micelle carries the negative charge on the surface in body circulation, the charge responds to the faintly acid environment and is inversed into positive charge after reaching the tumor area, cellular uptake and intracellular drug delivery of the nano-micelle are promoted, the passive targeting property of the anti-tumor medicines is improved, the toxic or side effect of the medicine is reduced, and a new thought is provided for novel medicine targeting administration.

The present invention discloses one kind of arthritis treating Chinese medicine composition and its preparation process. The Chinese medicine composition contains the effective components of frankincense, myrrh, safflower, curcuma, clematis root and other six kinds of Chinese medicinal materials, and may be prepared into granule, tablet, capsule or other pharmaceutical preparation form. It has the functions of promoting blood circulation to disperse blood clots, dredging meridian and relieving pain, and may be used in treating rheumatic arthritis, rheumatoid arthritis, bone arthrosis, gout and ankylosing spondylitis.

The invention concerns an organic composition comprising glycerol polycarbonates, mixed with polyglycerols, [(a-hydroxymethyl)oxyethylene/(a-hydroxymethyl ethylene carbonate) copolymers; optionally [(a-alkyl)oxyethylene/(a-alkyl) ethylene carbonate] copolymers, optionally [(a-alkyl)oxyethylene/(a-hydroxyalkyl)oxyethylene] copolymers, glycerol carbonate and/or other organic carbonates, glycerol and/or other co-produced and/or residual compounds and a method for producing said composition. The inventive composition or the homopolymers and copolymers constituting same, are applicable in the technical fields of hydraulic fluids, lubrication, wood treatment and decoration, fire-retardant treatment, detergency, oil prospecting and production, water treatment, cosmetics, pharmaceutics, food industry and chemical intermediates.

This invention discloses a method for preparing amphiphilic chitosan derivative and its pharmaceutical application. The method comprises: connecting acylchlorinated long-chain fatty acid and chitosan by esterification, connecting end-activated poly (benzyl malate) and O-long-chain alkyl chitosan via amido bond, and performing catalytic hydrogenation to remove protective groups and obtain amphiphilic chitosan derivative. The amphiphilic chitosan derivative can form nanoparticles of 100-300 nm in aqueous solution, and has such advantages as high biodegradability, high biocompatibility and easy modification.

The present invention discloses an injectable in-situ crosslinked hydrogel and its preparation method. The preparation method is as below: Filling the crosslinking active solution of at least one kind of the biocompatible macromolecules containing more than two thiol groups on the side chains into an injectable container and sealing it, and forming the in-situ disulfide-bond crosslinked hydrogel under the action of the dissolved oxygen; through controlling such parameters as partial pressure of oxygen gas, temperature and time, regulating concentration of the oxygen dissolved in the crosslinking active solution, and optimizing the gelation process and the gel properties. The present invention further relates to application of the injectable in-situ crosslinked hydrogel in pharmaceutics or surgery. The present invention has many advantages, such as no need for a crosslinking agent, simple preparation process, convenient application, containing no impurities, good biocompatibility, no toxic and side effect, and wide application in the medical science.

The invention relates to a pharmaceutical preparation for treating gynaecologic diseases and regulating menstruation, its preparing process and quality control method, wherein the preparation is made mainly from Chinese angelica root, Ligusticum wallichii, prepared nutgrass flatsedge rhizome, white atractylodes rhizome, root of herbaceous peony and red peony root, and can be made into dispersible tablets, mini-pills, dripping pills, soft capsules and pharmacologically allowable dose forms. The invention also provides the method for determining and identifying contents of the preparation.

The invention provides four triptolide derivatives and a preparation method of corresponding agents, which uses triptolide as raw material, via acylation and nucleophilic substitution to obtain triptolide derivative to be reacted with acid or alkyl halide to obtain a corresponding salt which can be added with one or more pharmaceutically acceptable adjuvants to prepare relative agent-freeze-driedpowder.

The invention relates to medicament containing nicacid or other Statin drugs, which is a double layer tablet, one of which contains clinically effective dose nicacid and slow release preparation findings acceptable in pharmaceutics, while the other layer contains clinically effective dose Statin drugs and slow release preparation findings acceptable in pharmaceutics.

The invention relates to a solution preparation for atomizing and inhaling ambroxol, and belongs to the field of pharmaceutics. The solution preparation for atomizing and inhaling the ambroxol comprises (1) ambroxol or medicinal salt thereof with single medicinal dosage, (2) isotonic agent and solvent, (3) buffer solution and (4) medicinal package with single dosage; and in terms of the ambroxol, the mass ratio of the medicinal components to the isotonic agent is 1:1.1-1:3.3.The invention provides the solution preparation for atomizing and inhaling the ambroxol with single dosage and the medicinal package adopting blowing-filling-sealing (BFS) integrative full-automatic production, which have the advantages that the medicinal package is designed and manufactured for patients special for atomizing and inhaling; the solution preparation does not contain preservative, and is used with disposable single dosage; the using process is convenient and does not need dilution and preparation; and the microbe pollution, waste and the like during using can be greatly reduced. The medicinal preparation provides a treatment medicament and a treatment proposal with accurate medicinal dosage, good-quality and stable medicament quality, and safe and simple clinical application lacking in the prior art.

The invention relates to a compound Chinese medicinal preparation for gall-stone. The compound Chinese medicinal preparation comprises the following Chinese medicinal raw materials by weight: 26-34 grams of longhairy antenoron herb, 8-12 grams of turmeric root-tuber, 8-12 grams of chicken gizzard membrane, 8-12 grams of rhubarb, 13-17 grams of baikal skullcap root, 13-17 grams of virgate wormwood herb, 5-7 grams of Chinese thorowax root, 8-12 grams of white paeony root, 5-7 grams of bitter orange, 5-7 grams of costus root and 5-7 grams of liquoric root. A preparation method of the compound Chinese medicinal preparation comprises the following steps of: cleaning the eleven types of medicinal materials; mixing proportionally; adding water or 70 percent by volume of ethanol, with an amount which is 4-6 times the total weight of the medicinal materials for decocting for twice for 80 minutes each time; mixing decoction solutions obtained in the three times; filtering; and concentrating to obtain a liquid extract of which the specific weight is 1.13 at 60 DEG C. The compound Chinese medicinal preparation can be prepared into any pharmaceutical dosage form, such as tablets, capsules, granules, oral liquid, pills and syrup by adopting the conventional preparation process. The compound Chinese medicinal preparation has a remarkable curative effect, is superior to a western medicament therapy method, is free from untoward reactions, and is suitable for the requirements of the conventional gall-stone patients.