1217 results about "Pharmaceutics" patented technology

The present invention relates to whey protein micelles, particularly to whey protein micelle concentrates or powders thereof and to a method for producing them. The present invention also pertains to the use of these micelles concentrates or powders thereof in nutrition and / or cosmetics and / or pharmaceutics.

The invention discloses detumescent and analgesic ointment for curing rheumatism and contusion and a preparation method thereof. The ointment is a pure herbal pharmaceutics, which is composed of monarch drugs, ministerial drugs, adjuvant drugs and conductant drugs. The preparation method comprises the following steps: placing 5kg of tung oil in a pan; grinding all traditional Chinese bug bulk pharmaceutical chemicals (BPC) into refined powder, wrapping the adjuvant drugs and the conductant drugs with gauzes, and placing into a frying pan for boiling; boiling with charcoal fire for 90min, putting the powder in to the frying pan after generating smokes, and boiling the mixture to obtain semi-creamy mixture; placing the ministerial drugs into the pan for even stirring to obtain semi-creamy mixture; taking the pan away from the fire and putting the monarch drugs into ointment for even stirring; placing 2.5kg of rosin into the ointment and evenly stirring to obtain the ointment, and pasting the ointment on kraft papers with 11 centimeters; and pressing the ointment on the kraft papers by a 6-centimeter iron module to obtain the ointment with diameter of 6 centimeters, and placing the obtained ointment on fixed patches. The detumescent and analgesic ointment for curing rheumatism and contusion can be used for stimulating the circulation of the blood and causing the muscles and joints to relax, relieving bruises and pains, and curing traumatic injuries and rheumatoid arthritis.

invention discloses a kit for a serum micro-ribonucleic acid and the application in the early diagnosing of hepatitis B thereof which belong to the technical field of biotechnological pharmaceutics. The invention provides the combination of the micro-ribonucleic acid used for estimating the physiological and / or pathological states of a normal person, a HBVer and a patient with hepatitis B; the combination comprises all the micro-ribonucleic acids which have differential expression in the serum / plasm of the normal person, the HBVer and the patient with hepatitis B and prepares a diagnosing kit which can be used for the early diagnosing of hepatitis B. The combination and the method can be used for the early detection and nondirective therapy of hepatitis B; besides, the combination and the method have the advantages of high specificity, high efficiency, high sensitivity, low detection cost, convenient material obtaining, and the like. Besides, the samples are easily stored.

The present invention relates to a process of producing Maillard flavour preparation, such as process flavours, comprising heating a combination of a carbohydrate source and a nitrogen source in a continuous liquid phase containing at least 10 wt % of an α-hydroxycarboxylic acid component selected from tne group of α-hydroxycarboxylic acids according to the following formula (I): R1—CR2(OH)—COOH salts of these acids and combinations thereof. It was found that the flavour preparations so obtained exhibit unique flavour profiles, making them particularly suitable for use in foodstuffs, beverages, pharmaceutics, tobacco products and oral care products.

The invention provides a device for separating a first entity and a second entity by flowing them downwardly in an inclined settling chamber. Each entity has its own outlet located at approximately the lowest end of the inclined settling chamber. The device may be used in industrial fields such as pharmaceutics, biologics, and biofuels, for the purposes of large-scale growth and separation of algae biomass, bacteria and yeast cultures; algae metabolite production; and cell separation, among others. The invention exhibits technical merits such as effective particle separation or concentration capacity, robust structure, easy operation, cost-effective manufacturability, disposability, and high productivity in e.g. perfusion photobioreactor systems.

The invention discloses a traditional Chinese medicine composition for treating respiratory tract haze disoperation and a preparation method, the composition comprises the following bulk drugs by weight: 10-30 g of balloonflower root, 1-15g of Zhejiang fritillaria bulb, 1-15g of grosvenor momordica fruit and 1-15g of licorice. The traditional Chinese medicine composition has the efficacy of dispersing lung Qi, lifting airway self-cleaning capability and eliminating harmful substances, in vitro and clinical verifies that the traditional Chinese medicine composition has the accurate curative effect for preventing and treating respiratory tract haze disoperation without toxic and side-effect. The above materials are ground to crude powder and packed in a tea bag, and brewed by boiled water, or water is used for immersing the bulk drugs for 20 minutes, the water decoction is carried out for 15 minutes, the above materials are filtered for drinking as tea, and auxiliary materials and a corrigent are cooperated, an oral liquid, a syrup, a capsule, a particulate agent, a tablet and effervescence particles which can be accepted on pharmacy are prepared directly or indirectly through conventional procedures, and the traditional Chinese medicine composition can be clinically used for treating or preventing the respiratory tract diseases caused by the haze disoperation.

The invention relates to a disposable packaging item capable of being sterilised and / or depyrogenated. The invention in particular relates to the packaging of products and / or devices in the fields of medicine, pharmaceutics, chemistry, biology, food or electronics. The invention in particular relates to a disposable packaging item (1) at least partially produced with at least one thermoplastic film (10) that can withstand sterilisation and / or depyrogenation, said disposable packaging item (1) defining at least one inner enclosure (5) for receiving one or more elements (50) to be packaged, said inner enclosure (5) being under vacuum (40) and preferably sterile and / or depyrogenated, said packaging item (1) including one or more packaged elements (50).

A hydrate of brain protein is prepared from pig's brain through adding purified water, homogenizing, heating, cooling, regulating pH=1.5-2.0, enzymolyzing, regulating pH=7.7-8.0, enzymolyzing, regulating pH=2.5-3.0 freezing, thawing, filter, regulating pH to become neutral, ultrafiltering, concentrating, sterilizing, adding amino acids, regulating peptide map, diluting, and steam sterilizing.

The invention discloses a lutein ester health care product for protecting eyesight. The lutein ester health care product is prepared by taking lutein ester as a main material, and adding any one or more materials including taurine, selenium, zinc, alpha-lipoic acid, docosahexaenoic acid (DHA), vitamin A, vitamin E, vitamin B1, vitamin B2 and bilberry extract, and pharmaceutically acceptable formulation accessories. The outstanding innovation of the invention is the implementation of the method for preparing a functional eye health care product with the lutein ester instead of lutein, so that the bioavailability, the stability and the health care effect of the product are improved, and production cost can be greatly reduced. The health care product can be prepared into common dosage forms, such as tablets, capsula, granules and soft capsules. The lutein ester health care product is mainly used for the treatment on diseases, such as myopia, amblyopia, hyperopia, presbyopia, cataract, vitreous opacity, retinal pigment degeneration, macular degeneration, asthenopia, and retinopathy caused by diabetes, and the like. The lutein ester health care product adopts a unique formulation of multiple constituents, measures and mechanisms, and has significant treatment effects and excellent social and economic benefits.

The invention relates to the pharmaceutical application of a medicament combination containing oil of zedoary turmeric. The medicament combination has new pharmaceutical application for preventing and treating various diseases, such as various HPV virus subtype infections, intraepithelial lesion(isl), papilloma and cervical carcinoma, and the like, in particular to high-risk HPV subtype infections. The medicament is prepared into various conventional formulations in the category of pharmaceutics, and the medicament combination can significantly prevent and treat multiple related diseases of HPV infection by clinical verification.

The invention relates to the technical field of pharmaceutical nanoemulsion drug delivery systems and transdermal absorption, in particular relates to ginseng-containing whitening and anti-aging nanoemulsion essence and a preparation method thereof, and belongs to a new pharmaceutical technology and the field of study on new formulations applied to cosmetics. The nanoemulsion essence is characterized in that a natural or food-grade emulsifier and an oil phase are selected, wherein double distilled water containing fruit juice, vegetable juice or honey is used as an oil phase. The nanoemulsion essence comprises the following components in percent: 10.30 to 80.60% of emulsifier / co-emulsifier, 1.0 to 40.80% of oil phase, 0.10 to 14.0% of ginseng, and the balance of the water phase. The confocal microscopy result shows that the transdermal absorption mechanism of the essence is the mechanism of majorly dispersing among cells of cutaneous appendages at the beginning and then dispersing and penetrating through cytomembrane. The nanoemulsion essence has high absorption, is innocuous, unpoisonous and pollution-free, does not damage the skin, and can completely realize the green, health, whitening, anti-aging and beautifying makeup concept.

The invention relates to a tadalafil orally disintegrating tablet and a preparation method thereof. Aiming to improve the deficiency of existing tadalafil oral dosage forms, the invention provides the tadalafil orally disintegrating tablet which is convenient to take, is quick in absorption, takes effect quickly and has high bioavailability for doctors and patients to help the patients achieve requirements for natural and satisfactory sexual lives. The tadalafil orally disintegrating tablet takes tadalafil or medicinal salts thereof as an active ingredient, contains pharmaceutically acceptable auxiliary materials such as filling agents, disintegrating agents, flavouring agents and lubricating agents, and when being taken, dispenses with water, can be quickly disintegrated or dissolved in oral cavities only in a few seconds and is ingested along with saliva.

The present invention is a kind of bupleurum root extract and its extracting process and medicinal use, and belongs to the field of Chinese medicine technology. The bupleurum root extract is obtained through extracting bupleurum root with alcohol solution, and contains bupleurum saponin-a in 20-30 wt% and bupleurum saponin-d in 10-20 wt%. The preparation process includes crushing bupleurum root, extraction, concentration, column chromatography, eliminating saccharide, depurating, eluting, decolorizing, concentrating, drying and other steps. The extract has high effective component content, high purity, and excellent medicinal application for resisting inflammation, resisting virus, resisting tumor, regulating incretion, etc.

The invention relates to the fields of high polymer chemistry and pharmaceutical preparation and in particular relates to preparation of a multifunctional linear-dendritic segmented copolymer and application in pharmaceutics thereof. The multifunctional linear-dendritic segmented copolymer has the amphipathy, indissolvable drugs can be obviously dissolved, the drug stability and the in-vivo bioavailability are improved, particularly indissolvable or water-soluble drugs can be coated, and the drugs are self-assembled to form nano-micelle. The modified polyamidoamine structure has the charge inversion property of environmental response, so that the micelle carries the negative charge on the surface in body circulation, the charge responds to the faintly acid environment and is inversed into positive charge after reaching the tumor area, cellular uptake and intracellular drug delivery of the nano-micelle are promoted, the passive targeting property of the anti-tumor medicines is improved, the toxic or side effect of the medicine is reduced, and a new thought is provided for novel medicine targeting administration.

The invention provides a metformin hydrochloride controlled-release tablet, which comprises a metformin hydrochloride controlled-release tablet with effective dose and pharmaceutical accessories and is characterized in that the metformin hydrochloride controlled-release tablet uses the common tabletting, and the controlled-release effect is controlled by totally depending on the film coating technique. The coating adopted by the invention is a releasing system comprising the prescription which can cause the medicine to reach release degree standard in vitro. The preparation method in the invention is simple and convenient; the process conditions are easy to control and suitable for batch production, can use conventional production equipment in pharmaceutical industries for economically and conveniently producing the metformin hydrochloride controlled-release tablet on a large scale, can effectively and stably cause the release degree of the metformin hydrochloride controlled-release tablet in the second hour to be 10% to 35%, the release degree to be 40% to 70% in the sixth hour and the release degree to be more than 80% in the twelfth hour.

The invention belongs to the field of microbial pharmaceutics and pharmaceutical engineering, specifically relates to a production method of prednisone acetate by microbial transformation with Arthrobacter simplex as bacteria strain and hydrocortisone acetate as substrate. The method uses Arthrobacter simplex as bacteria strain and comprises the following steps of: performing primary seed culture, performing second fermentation culture, adding hydrocortisone acetate into the fermentation liquid of Arthrobacter simplex to transform hydrocortisone acetate into prednisone acetate, filtering, and collecting cake to obtain prednisone acetate. The bacteria can be prepared into double liquid phase, broken cells or protoplast, each of which has high transformation ratio. The inventive production method replaces cortisone acetate with hydrocortisone acetate as raw material, and has the advantages of high yield, simple process, good economical and practical performance, and less use of harmful reagents; and is important for steroids production with biotransformation method.

The invention discloses an anticancer and antalgic Chinese medicinal Gelsmium elegans total alkaloid and drug combination containing it as well as its preparing method, where the Gelsmium elegans total alkaloid is extracted from the raw material Chinese medicinal Gelsmium elegans and the Gelsmium elegans total alkaloid and acceptable carrier or excipient in any pharmacy are made into drug combination whose drug form can be oral preparation and also injection, concretely speaking tablet, capsule, soft capsule, oral solution, injection solution, transfusion, powder injection and freeze-dried powder injection. The drug combination has good anticancer effect and high-quality ntalgic function and the drug combination's antalgic strength is inferior to morphia's and superior to other clinical antalgics'.

The invention discloses an oral disintegration tablet of alcaine aminobromisuo, which contains alcaine aminobromisuo with effective dosage and pharmacological findings, wherein the alcaine aminobromisuo is processed by metarchon with rate of aminobromisuo and metarchon at 1: 0. 1-1. 5, which is blended with pharmacologically acceptable findings; the metarchon can be medically inorganic oxide or / and medicinal organic acid and salt; the acceptable findings is filler, corrigent, disintegration agent, adhesive and lubricant; the oral disintegration tablet of alcaine aminobromisuo hasn't bitterness and numb sense to disintegrate within one minute with stripping degree not less than 90%. The invention is convenient and simple to control with high yield and low energy consumption, which widens the resource of metarchon to save cost.

The present invention discloses one kind of arthritis treating Chinese medicine composition and its preparation process. The Chinese medicine composition contains the effective components of frankincense, myrrh, safflower, curcuma, clematis root and other six kinds of Chinese medicinal materials, and may be prepared into granule, tablet, capsule or other pharmaceutical preparation form. It has the functions of promoting blood circulation to disperse blood clots, dredging meridian and relieving pain, and may be used in treating rheumatic arthritis, rheumatoid arthritis, bone arthrosis, gout and ankylosing spondylitis.

The invention concerns an organic composition comprising glycerol polycarbonates, mixed with polyglycerols, [(a-hydroxymethyl)oxyethylene / (a-hydroxymethyl ethylene carbonate) copolymers; optionally [(a-alkyl)oxyethylene / (a-alkyl) ethylene carbonate] copolymers, optionally [(a-alkyl)oxyethylene / (a-hydroxyalkyl)oxyethylene] copolymers, glycerol carbonate and / or other organic carbonates, glycerol and / or other co-produced and / or residual compounds and a method for producing said composition. The inventive composition or the homopolymers and copolymers constituting same, are applicable in the technical fields of hydraulic fluids, lubrication, wood treatment and decoration, fire-retardant treatment, detergency, oil prospecting and production, water treatment, cosmetics, pharmaceutics, food industry and chemical intermediates.

This invention discloses a method for preparing amphiphilic chitosan derivative and its pharmaceutical application. The method comprises: connecting acylchlorinated long-chain fatty acid and chitosan by esterification, connecting end-activated poly (benzyl malate) and O-long-chain alkyl chitosan via amido bond, and performing catalytic hydrogenation to remove protective groups and obtain amphiphilic chitosan derivative. The amphiphilic chitosan derivative can form nanoparticles of 100-300 nm in aqueous solution, and has such advantages as high biodegradability, high biocompatibility and easy modification.

The purpose of this invention is:new selenohydroxy acid compounds and their derivatives;their process for the preparation;use of the new compounds as precursors of L(+)-selenomethionine and / or source of selenium in human or animal nutrition, in cosmetics and pharmaceutics;and nutritional, cosmetic and pharmaceutical compositions containing them.The new compounds that are the subject of this invention satisfy the general formula (I):in whichn=0, 1 or 2,R1=OH, OCOR3, OPO3H2, OPO(OR4)(OR5), or OR6,R2=OH, R3, or NHR7,R3=particularly alkoxyl (C1-C26), ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6a and 6b, S-cysteinyl, or S-glutathionyl, carnitoyl, lipids, polyols,OR4=OR5=particularly alkoxyl (C1-C26), ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6a and 6b, S-cysteinyl, or S-glutathionyl, carnitoyl, lipids, polyols,OR6=pyruvate, lactate, citrate, fumarate, maleate, myristate, palmitate, stearate, palmitoleate, oleate, linoleate, natural fatty acids, or 13-cis retinoate,R7=H, alkyl, natural amino acids, or natural amines.

The present invention discloses an injectable in-situ crosslinked hydrogel and its preparation method. The preparation method is as below: Filling the crosslinking active solution of at least one kind of the biocompatible macromolecules containing more than two thiol groups on the side chains into an injectable container and sealing it, and forming the in-situ disulfide-bond crosslinked hydrogel under the action of the dissolved oxygen; through controlling such parameters as partial pressure of oxygen gas, temperature and time, regulating concentration of the oxygen dissolved in the crosslinking active solution, and optimizing the gelation process and the gel properties. The present invention further relates to application of the injectable in-situ crosslinked hydrogel in pharmaceutics or surgery. The present invention has many advantages, such as no need for a crosslinking agent, simple preparation process, convenient application, containing no impurities, good biocompatibility, no toxic and side effect, and wide application in the medical science.

The invention relates to a pharmaceutical preparation for treating gynaecologic diseases and regulating menstruation, its preparing process and quality control method, wherein the preparation is made mainly from Chinese angelica root, Ligusticum wallichii, prepared nutgrass flatsedge rhizome, white atractylodes rhizome, root of herbaceous peony and red peony root, and can be made into dispersible tablets, mini-pills, dripping pills, soft capsules and pharmacologically allowable dose forms. The invention also provides the method for determining and identifying contents of the preparation.

The invention provides four triptolide derivatives and a preparation method of corresponding agents, which uses triptolide as raw material, via acylation and nucleophilic substitution to obtain triptolide derivative to be reacted with acid or alkyl halide to obtain a corresponding salt which can be added with one or more pharmaceutically acceptable adjuvants to prepare relative agent-freeze-driedpowder.

The invention relates to medicament containing nicacid or other Statin drugs, which is a double layer tablet, one of which contains clinically effective dose nicacid and slow release preparation findings acceptable in pharmaceutics, while the other layer contains clinically effective dose Statin drugs and slow release preparation findings acceptable in pharmaceutics.

The invention provides a preparation and synthesis method of basic amino acid medicine salt of a dextral optical isomer in ibuprofen that is the existing anti-inflammation antipyretic and analgesic, and a medicinal combination thereof. After being mixed with necessary auxiliary material, the medicine salt can be prepared into oral solid preparations such as oral liquid, granules, tablets, dispersible tablets, capsules, coated tablets, sustained release tablets, collocystis, etc. through necessary pharmaceutics operations, and can also be prepared into the preparations for intravenous injection such as hydro-acupuncture, freeze-dried powders, aseptic powders, high volume transfusions, etc.

The present invention relates to a Chinese Tibet medicine for mainly curing the diseases of acute and chronic sprain and contusion, rheumatism and rheumatoid disease and its preparation method. It is characterized by that said preparation method includes the following steps: utilizing the Chinese Tibet medicinal materials of lamiophlomis rotate, Jidou, turmeric, zanthoxylum husk, water buffalo horn and myricaria germanica as raw material, making them undergo the processes of decocting, vacuum freeze-drying, pulverizing and making them into any pharmaceutically-acceptable dosage form, including oral preparation or preparation for external application, in particular, it can be made into the adhesive plaster, ointment preparation, spray, gel preparation, film preparation and resin plaster, etc.

The invention relates to a solution preparation for atomizing and inhaling ambroxol, and belongs to the field of pharmaceutics. The solution preparation for atomizing and inhaling the ambroxol comprises (1) ambroxol or medicinal salt thereof with single medicinal dosage, (2) isotonic agent and solvent, (3) buffer solution and (4) medicinal package with single dosage; and in terms of the ambroxol, the mass ratio of the medicinal components to the isotonic agent is 1:1.1-1:3.3.The invention provides the solution preparation for atomizing and inhaling the ambroxol with single dosage and the medicinal package adopting blowing-filling-sealing (BFS) integrative full-automatic production, which have the advantages that the medicinal package is designed and manufactured for patients special for atomizing and inhaling; the solution preparation does not contain preservative, and is used with disposable single dosage; the using process is convenient and does not need dilution and preparation; and the microbe pollution, waste and the like during using can be greatly reduced. The medicinal preparation provides a treatment medicament and a treatment proposal with accurate medicinal dosage, good-quality and stable medicament quality, and safe and simple clinical application lacking in the prior art.