3274 results about "Carboxyl radical" patented technology

A γ,δ-unsaturated carboxylic acid silyl ester is prepared by reacting an α,β-unsaturated carboxylic acid ester with a hydrosilane or hydrosiloxane in the presence of tris(pentafluorophenyl)borane. γ,δ-Unsaturated carboxylic acid derivatives are readily prepared through fewer steps and in high yields.

The light emitting device of the present invention relates to a light emitting device which is characterized in that it is a device with an emissive substance present between an anode and cathode, and which emits light by means of electrical energy, and said device has a least one type of compound denoted by (a) to (d) below. (a) A compound having a plurality of 1,7-phenanthroline skeletal structures (b) A benzoquinoline derivative (c) A spiro compound represented by general formula (1) A1 and A2 are each selected from single bonds, substituted or unsubstituted alkyl chains, ether chains, thioether chains, ketone chains and substituted or unsubstituted amino chains. However, A1<> A2. Z represents carbon or silicon. R1 to R16 are each selected from hydrogen, alkyl group, cycloalkyl group, aralkyl group, alkenyl group, cycloalkenyl group, alkynyl group, hydroxyl group, mercapto group, alkoxy group, alkylthio group, aryl ether group, aryl thioether group, aryl group, heterocyclic group, halogen, haloalkane, haloalkene, haloalkyne, cyano group, aldehyde group, carbonyl group, carboxyl group, ester group, carbamoyl group, amino group, nitro group, silyl group, siloxanyl group and a cyclic structure formed with an adjacent substituent. (d) A tetraphenylmethane derivative represented by general formula (2) R17 to R36 are each selected from hydrogen, alkyl group, cycloalkyl group, aralkyl group, alkenyl group, cycloalkenyl group, alkynyl group, hydroxyl group, mercapto group, alkoxy group, alkylthio group, aryl ether group, aryl thioether group, aryl group, heterocyclic group, halogen, haloalkane, haloalkene, haloalkyne, cyano group, aldehyde group, carbonyl group, carboxyl group, ester group, carbamoyl group, amino group, nitro group, silyl group, siloxanyl group and a cyclic structure formed with an adjacent substituent. However, at least one of R17 to R36 is selected from substituents represented by general formula (3). -X-Ar (3) X is a single bond or is selected from the following, and Ar denotes a condensed aromatic ring or heteroaromatic ring. In the case where X is phosphorus oxide, then Ar represents an aromatic hydrocarbon or heteroaromatic ring. n is an natural number.

A method of treating a subject having a musculoskeletal disorder includes administering to a subject's articular site in need thereof an effective amount of a hyaluronic acid (HA) composition. In one embodiment, the HA composition includes an HA derivative, wherein carboxyl functionalities of the hyaluronic acid derivative are each independently derivatized to include an N-acylurea or 0-acyl isourea, or both N-acylurea and 0-acyl isourea. In another embodiment, the HA composition includes a crosslinked HA gel that is prepared by reacting an uncrosslinked HA with a biscarbodiimide in the presence of pH buffer in a range of between about 4 and about 8. The composite can optionally include at least one second bioactive agent other than the HA derivative, such as a steroid.

The invention provide a class of chain-extended polysiloxane crosslinkers which comprises (1) at least two polysiloxane segments, wherein each pair of adjacent polysiloxane segments is linked by one divalent organic radical which includes at least one pendant hydrophilic group (hydroxyl and/or carboxyl groups) or at least one dangling hydrophilic polymer chain and a di-thioether linkage —S-DR—S— in which DR is a divalent organic radical; and (2) two terminal ethylenically unsaturated groups. The present invention is also related to a polymer comprising crosslinking units derived from chain-extended polysiloxane crosslinker of the invention and to ophthalmic lenses comprising such a polymer.

A hydrosilylation catalyst is provided wherein a platinum catalyst is enclosed in a heat-fusible compound having a melting point of 40-200 DEG C. and containing an aliphatic unsaturated bond, carbonyl, carboxyl or thioether radical in a molecule. The catalyst is blended in organo-polysiloxane to form a silicone composition having both shelf stability and fast-curing capability.

The compound represented by the general formula (I):

• • wherein, a fused ring AB represents a 5- to 10-membered fused heterocyclic ring; R¹ represents (1) a hydrogen atom, (2) a halogen atom, (3) a cyano group, (4) an oxo group, (5) an optionally protected hydroxyl group, (6) an optionally protected carboxyl group, (7) an optionally protected amino group, (8) a cyclic group which may have a substituent (s), (9) an aliphatic hydrocarbon group which may have a substituent (s), or (10) an optionally protected thiol group; n represents 0 or an integer of 1 to 8; provided that n represents an integer of not less than 2, plural R¹ are the same or different; a salt thereof, a solvate thereof or a prodrug thereof has a kinase (especially c-Jun N-terminal kinase) inhibitory activity and an inhibitory activity of a function of AP-1 as a transcription factor, it is useful as a preventive and/or therapeutic agent for a for example, a diabetes of metabolic disease, etc., a rheumatoid arthritis of inflammatory, etc.

A light emitting device material containing a pyrene compound of formula (1) and a light emitting device. In formula (1), R¹ to R¹⁸ are the same or different and are selected from hydrogen, alkyl, cycloalkyl, heterocyclic, alkenyl, cycloalkenyl, alkynyl, alkoxy, alkylthio, arylether, arylthioether, aryl, heteroaryl, halogen, carbonyl, carboxyl, oxycarbonyl, carbamoyl, amino, phosphine oxide and silyl; adjacent substituents among R¹ to R¹⁸ may be combined with each other to form a ring; n represents an integer of 1 to 3; X is —O—, —S— or —NR¹⁹—; R¹⁹ is selected from hydrogen, alkyl, cycloalkyl, heterocyclic, alkenyl, cycloalkenyl, alkynyl, aryl, heteroaryl or amino; R¹⁹ may be combined with R¹¹ or R¹⁸ to form a ring; Y is a single bond, arylene or heteroarylene; and n substituents among R¹ to R¹⁰ and any one of R¹¹ to R¹⁹ are used for linkage with Y

[Problem] To provide detergent compositions with superior surfactant deposition-inhibiting ability and anti-gelling properties that exhibit good cleaning effectiveness even when laundering under harsh conditions such as laundering in residual bath water.

[Solution] A laundry detergent or cleaning composition which comprises a copolymer containing sulfonate groups containing from 1 to 50 mass percent of structural units (a) derived from 1 or more kinds of monomers (A) selected from ether bond-containing monomers represented by Formulas (1) and (2), 50 mass % or more and less than 98 mass % of structural units (b) derived from a carboxyl group-containing monomer (B), and 1 mass % or more and less than 50 mass % of structural units (c) de-rived from a sulfonate group-containing monomer (C).

Novel carboxylic acid derivatives of general formula (I), salts of the same, esters thereof, or hydrates of them, which are useful as insulin resistance improvers; and drugs containing the derivatives as the active ingredient. In said formula, R¹ is hydrogen, hydroxyl, alkyl, or the like; L is a single bond, a double bond, alkylene, or the like; M is a single bond, alkylene, or the like; T is a single bond, alkylene, or the like; W is carboxyl, —CON(R^W1)R^W2, or the like; represents a single or double bond; X is oxygen, alkenylene, or the like; Y is an aromatic hydrocarbon group which may contain a heteroatom, or the like; and Z is an aromatic hydrocarbon group which may contain a heteroatom.

The invention provides a method for preparing a viscosity-reduction-type polycarboxylic acid superplasticizer and application of the viscosity-reduction-type polycarboxylic acid superplasticizer. The method is simple in operating process, and the prepared polycarboxylic acid superplasticizer is applied to high- and ultrahigh-strength concrete, can be used for effectively lowering the viscosity of concrete and improving the placeability and flow velocity of the concrete and is beneficial to pumping construction. According to the method, the viscosity-reduction-type polycarboxylic acid superplasticizer is prepared through carrying out free-radical copolymerization on a carboxylic monomer a, a branched side chain containing monomer b and a rigid cyclic group containing monomer c which are in the mole ratio of (4-15): 1: (0.5-2). The polycarboxylic acid superplasticizer prepared by the method provided by the invention can serve as a cement dispersant so as to greatly lower the water-cement ratio of concrete; and the polycarboxylic acid superplasticizer can be used for effectively lowering the viscosity of the high- and ultrahigh-strength concrete and improving the placeability and flow velocity of the concrete, so that the pumpability is excellent.

The invention provides a method for extracting carbon quantum dots from activated carbon, which comprises the following steps of: adding dry activated carbon powder to salpeter solution and stirring for backflow; performing reduced pressure distillation for evaporating suspension obtained by backflow to dryness; dispersing obtained black solids in water, and neutralizing obtained solution with sodium hydroxide; and finally, centrifugating neutralized black suspension for removing precipitation, separating supernatant fluid by using an ultrafiltration centrifugal tube or an ultrafiltration membrane, collecting filtrate, and drying the filtrate to obtain carbon quantum dots. The method uses cheap and available activated carbon as carbon sources, and can obtain a large number of carbon quantum dots by simple chemical oxidation process and simple subsequent processes of evaporation, saturation, centrifugation and ultrafiltration. The carbon quantum dots are graphite structure nanocrystals with the grain diameter of 3 to 5 nm, the surfaces of which have a large amount of hydroxide radicals. The carbon quantum dots have good fluorescence and electrochemiluminescence.

The present invention is directed to a derivative comprised of an L-Threonine bonded to a medicament or drug having a hydroxy, amino, carboxy or acylating derivative thereon. The derivative has the same utility as the drug from which it is made, but it has enhanced therapeutic properties. In fact, the derivatives of the present invention enhance at least one or more therapeutic qualities, as defined herein. The present invention is also directed to pharmaceutical compositions containing same.

The present invention is a substantially purified sortase-transamidase enzyme from Gram-positive bacteria, such as Staphylococcus aureus. The enzyme having a molecular weight of about 23,539 or about 29,076 daltons and catalyzing a reaction that covalently cross-links the carboxyl terminus of a protein having a sorting signal to the peptidoglycan of a Gram-positive bacterium, the sorting signal having: (1) a motif of LPX3X4G therein; (2) a substantially hydrophobic domain of at least 31 amino acids carboxyl to the motif; and (3) a charged tail region with at least two positively charged residues carboxyl to the substantially hydrophobic domain, at least one of the two positively charged residues being arginine, the two positively charged residues being located at residues 31-33 from the motif, wherein X3 is any of the twenty naturally-occurring L-amino acids and X4 is selected from the group consisting of alanine, serine, and threonine, and wherein sorting occurs by cleavage between the fourth and fifth residues of the LPX3X4G motif. Variants of the enzyme, methods for cloning the gene encoding the enzyme and expressing the cloned gene, and methods of use of the enzyme, including for screening for antibiotics and for display of proteins or peptides on the surfaces of Gram-positive bacteria, are also disclosed.

The invention relates to magnetic silicon dioxide microspheres with a nuclear shell and surface anisotropic double functional groups and a preparation method thereof. The preparation method comprises the following steps of: preparing superparamagetic microspheres by a solvothermal process; preparing magnetic microspheres which are coated by silicon dioxide by a sol-gel process; preparing the magnetic silicon dioxide microspheres of which the surface has amino group by taking the magnetic silicon dioxide microspheres as seeds and by the copolycondensation of alkyl ester orthosilicate and a silane coupling agent, and drying the magnetic silicon dioxide microspheres to obtain samples; and by a PICKERING emulsion technology, stabilizing a paraffin/aqueous emulsion system with a micrometer scale by using the aminated magnetic microspheres to form single-layer close packing of the magnetic microspheres on the surface of paraffin spheres, then reacting the amino group on the surface of the magnetic microspheres which is exposed in a liquid phase with succinic anhydride to introduce carboxyl into the partial surface of the microspheres, so that the surfaces of the magnetic microspheres have the anisotropic double functional groups. The obtained magnetic microspheres with the double functional groups have the advantages that: magnetic responsiveness is high; grain size can be controlled between 200 and 800 namometers; and the density of the surface functional groups can be adjusted.

The present invention relates to an amino-functional polysiloxane of formula (1) where each R¹ is independently selected from alkyl or aryl radicals, each R² is independently selected from hydrogen, alkyl or aryl radicals, n is selected so that the molecular weight for the functional polysiloxane is in the range of from 400 to 10,000 and R³ is a bivalent radical or —O—R³—NH—R⁵ is hydroxy or alkoxy, and R⁵ is selected from hydrogen, aminoalkyl, aminoalkenyl, aminoaryl, aminocycloalkyl radical, optionally substituted by alkyl, aryl, cycloalkyl, halogen, hydroxy, alkoxy, thioalkyl, amino, amino derivatives, amido, amidoxy, nitro, cyano, keto, acyl derivatives, acyloxy derivatives, carboxy, ester, ether, esteroxy, heterocycle, alkenyl or alkynyl and where 0 to 90% of —O—R³—NH—R⁵ is hydroxy or alkoxy. The present invention further relates to an epoxy-polysiloxane composition which includes an aminopolysiloxane hardener component or an amino-functional polysiloxane hardener component of formula (1), having active hydrogens able to react with epoxy groups in an epoxy resin to form epoxy polymers, and able to react with a polysiloxane to form polysiloxane polymers, wherein the epoxy chain polymers and polysiloxane polymers polymerize to form a cured epoxy-polysiloxane polymer composition.

The present invention provides a novel compound having an excellent PPAR agonist action. More specifically, it provides a compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them.

Wherein a, b and c are the same as or different from one another and each represents 0 to 4; R¹ to R⁶ are the same as or different from one another and each represents a hydrogen atom, a hydroxyl group, a cyano group, a halogen atom, etc.;

• A¹ and A² are the same as or different from each other and each represents a single bond, an oxygen atom, etc.; L, M and T each represent a single bond, an alkylene group having one to six carbon atoms, etc.; W represents a carboxyl group;

the partial structure represented by the formula:  represents a single bond or a double bond;

X represents a single bond, an oxygen atom, —NR^X1CQ¹O—, etc.;

Y represents Y¹—Y²— (wherein Y¹ represents a 5 to 14-membered aromatic ring having one to four substituents, etc.; and Y² represents a single bond or a 5 to 14-membered aromatic ring); and the ring Z represents a 5 to 14-membered aromatic ring which have one to four substituents selected form the above-mentioned Group A, may have one or more hetero atoms and may be partially saturated.

A process for producing a water-absorbing resin, which comprises polymerizing (D) an aqueous solution comprising (A) at least one monomer component selected from the group consisting of an unsaturated carboxylic acid and salts thereof; (B) a compound having two or more unsaturated groups in a molecule; and (C) a compound having two or more functional groups which are capable of reacting with carboxyl groups in a molecule, the polymerization being conducted in such a manner that the following conditions (a) to (c) are simultaneously satisfied: (a) the molar ratio (B)/(C) being in the range of from 2x10-3 to 300, (b) the polymerization being initiated by a redox polymerization initiator, and (c) the maximum reaction temperature being in the range of from 60° to 100° C., and a water-absorbing resin having a degree of reduction in absorption magnification of from 1 to 16, and n absorption magnification under pressure of from 20 to 40.

Polymeric compounds of formula I comprising boronic acid are provided. These polymeric compounds are prepared either by grafting boronic acid containing compounds (e.g. 4-carboxyphenylboronic acid) to hydrolysed poly(N-vinylformamide) or hydrolysing copolymer(s) obtained by copolymerizing vinyl group containing boronic acid monomers (e.g. -vinylphenyl boronic acid) and N-vinylformamide. These polymeric compounds are used in increasing the wet strength of paper in paper-making processes. Formula (I).

The invention relates to a prodrug that is capable of being converted into a drug by the catalytic action of human fibroblast activation protein (FAPalpha), said prodrug having a cleavage site which is recognized by FAPalpha, and said drug being cytotoxic or cytostatic under physiological conditions, wherein said prodrug comprises an oligomeric part comprising at least two amino carboxylic residues, and a cytotoxic or cytostatic part, wherein the C-terminal amino carboxylic residue of the oligomeric part is an acyclic amino acid, the nitrogen atom of the amino function thereof is attached to a substituent being different from a hydrogen atom, and the C-terminal carboxy function thereof is linked to the cytotoxic or cytostatic part by an amide bond.