239 results about "Carboxyl radical" patented technology

The application discloses a lateral test strip for detecting C-reactive protein and application thereof, and the test strip comprises a bottom plate and a sample pad, a combination pad, a nitrocellulose membrane and a water absorption paper which are sequentially stacked on the bottom plate; the combination pad is loaded with AIE fluorescent microspheres; the AIE fluorescent microspheres are composed of P(St-MMA) microspheres coated with AIE materials after hydrolysis and carboxylation; and anti-C-reactive protein antibodies are connected to the AIE fluorescent microspheres through a covalent bond. The surface coating amount of the AIE fluorescent microspheres is increased by 1.6-2.3 times, and the fluorescence intensity per unit mass is increased by about 40-60%. The increase of the coating amount makes the density of the light-emitting core higher, the overall quantum yield is significantly improved, and the uniformity of the fluorescence signal and the detection sensitivity are enhanced. The characteristics are particularly prominent in the detection of CRP protein in the chromatographic test strip, and the detection limit can be effectively reduced, the T / C signal ratio can be improved, and the reaction time can be shortened.

This application provides a method for simultaneously detecting hydroxy acids and keto acids in a sample. The method includes the following steps: preparing a standard solution; performing ketone and carboxyl derivatization on the sample to be tested containing hydroxy acids and keto acids to obtain the sample to be tested; performing ketone and carboxyl derivatization on the standard solution to obtain a derivatized standard solution; and sequentially adding a ketone derivatization reagent and... 13 The method involves derivatization with a C6-labeled carboxyl derivatization reagent to obtain an isotope internal standard solution. This solution is then added to both the sample to be tested and the derivatized standard solution for LC-MS / MS analysis. The method described in this application achieves unified detection of paired hydroxy acids and keto acids by selectively derivatizing the ketone group followed by the carboxyl group. A sequential derivatization strategy is constructed based on the functional group differences between keto and hydroxy acids, significantly improving the stability, repeatability, and quantitative reliability of keto acid detection while enhancing overall detection sensitivity.

The application discloses a capillary open-tube chromatographic column preparation method based on a defect engineering metal organic framework-molecular imprinting composite nanomaterial and application, and particularly relates to the field of chemical synthesis and analysis technology. A GLYMO-IDA-silane solution is used to flush a pretreated capillary, so that a carboxyl-modified capillary is obtained. Then, an N,N-dimethylformamide solution containing zirconyl chloride octahydrate, terephthalic acid, L-proline and hydrochloric acid is injected into the cysteine-modified capillary, and under a heating condition, a metal organic framework UiO-66-L-Pro is in-situ grown on the inner wall of the capillary. D-tryptophan and norepinephrine are dissolved in a neutral buffer solution, and after magnetic stirring for 30 min, ferrous sulfate is added and rapidly injected into the UiO-66-L-Pro-modified capillary, and then both ends are sealed, and reaction is carried out at room temperature for 24 h. An acetic acid / SDS solution mixture is used to flush the capillary for 1.5 h to elute the template molecules, and then nitrogen is used to blow dry, so that an MIP@UiO-66-L-Pro@capillary is prepared.

This application discloses a purino[1,2-a]carbazolin derivative, its preparation method, and its application. Specifically, it discloses a compound having the structure shown in Formula I, or its stereoisomers, solvates, metabolites, pharmaceutically acceptable salts, cocrystals, or prodrugs: ; wherein R1 and R2 are each independently selected from hydrogen, hydroxyl, carboxyl, substituted or unsubstituted C1-C6 alkyl, -CONH-R3, and -COO-R4; wherein R3 is a substituted or unsubstituted C1-C5 alkyl, and the substituent can be any of cyano, halogen, alkylC1-C5 alkoxy, C1-C5 alkylsulfonyl, di(C1-C5 alkyl)amino, nitrogen-containing heterocyclic, aryl, and C1-C5 heteroaryl; R4 is selected from any of substituted or unsubstituted aryl C1-C5 alkyl and nitrogen-containing saturated heterocyclic C1-C5 alkyl. This compound can be used as a TDP1 inhibitor for antitumor therapy.

This application relates to bioabsorbable cationic steroidal antimicrobial (CSA) compounds or salts thereof having a structure of formula I, II or III: formula (I), formula (II) or formula (III), wherein R1-R 18 At least one of them (e.g., R) 18 This includes monoglycerides or diglycerides of fatty acids linked by ester bonds, and R1-R 18 At least one of them (e.g., R3, R7, and R) 12 ) is an amino acid linked to the steroid backbone via an ester bond or an amide bond, wherein: R 18 It has the following structure: -R 19 -(C=O)-O-C-CR 20 -CR 21 , where R 19 The radical is omitted or selected from alkyl, alkenyl, ynyl, and aryl, and R 20 and R 21 Independently selected from hydroxyl, alkylcarboxyl, and aminoalkylcarboxyl groups, provided that R 20 and R 21 At least one of them is an alkyl carboxyl group, R3, R7 and R 12 It has the following structure: R 24 R 23 N-R 22 -(C=O)-X-, where R 22 It is a substituted or unsubstituted alkyl group, X is oxygen or nitrogen, and R is... 23 and R 24 It is independently hydrogen, alkyl, alkenyl, alkynyl, or aryl. (I)(II)(III)

The invention discloses copolymerized flame-retardant polycarbonate and a preparation method thereof. The preparation method comprises the following steps; diester carbonate, isosorbide, aliphatic diol, a first flame-retardant monomer and a second flame-retardant monomer are subjected to a reaction in the presence of a catalyst, and the copolymerized flame-retardant polycarbonate is obtained, wherein the first flame-retardant monomer comprises one or more than two of compounds with a structure as shown in a formula I: in the formula I, R1 and R2 are respectively and independently selected from one of carboxyl, alkyl ester group and hydroxyalkyl ester group; the second flame-retardant monomer comprises one or more than two of compounds with a structure as shown in a formula II; in the formula II, R3 and R4 are independently selected from one of carboxyl and alkyl ester. The polycarbonate provided by the invention has better thermal properties and mechanical properties while the flame retardant property is improved.

The application provides a method for recovering valuable metals in waste lithium battery black powder based on a eutectic solvent, uses a green solvent system composed of a choline / guanidine compound A containing a quaternary ammonium salt structure and an organic carboxylic acid compound B containing two or more carboxyl groups to recover valuable metals in waste lithium battery black powder, realizes preliminary and efficient separation of lithium cobalt manganese and nickel and graphite, recovers cobalt, manganese and lithium from the leaching solution through a step-by-step precipitation method after the lithium cobalt manganese enters the leaching solution, recovers nickel and graphite through acid dissolution separation of the mixture containing nickel and graphite, separates and recovers the mixture of nickel and graphite through subsequent treatment, the leaching conditions are mild, the pollution is small, the cost is low, and the method has good social and economic benefits; the method provided by the application can produce a plurality of high-value products, has the advantages of strong adjustability, high precipitation efficiency, green environmental protection and low cost, and has wide application value in the separation and recovery of valuable metals and graphite resources in battery black powder.

The application relates to the technical field of metal organic framework material preparation, and provides a metal organic compound and a preparation method thereof, the molecular formula of the metal organic compound is Zr6O m (OH) n (OL) 6‑(x+y) / 2 (sol) x (blank) y N b , 4<=m<=6, 0<=n<=4, 0.09<=x<=0.92, 1.8<=y<=6.02, 0.9<=b<=6.94; wherein, OL is a double-carboxyl conjugated organic ligand, sol includes at least one of acetate, formate and CH3(CH2) p COO ‑ , 1<=p<=6, blank is a ligand vacancy, and N is a counter ion; the unsaturated coordination defect rate of the metal organic compound is 15%-50.1%.

A layered double hydroxide (LDH) in a heterogeneous electrocatalytic sp 2 Application of C–H activation and CO2 carboxylation. The preparation method of a cobalt-iron molybdate intercalated hydrotalcite (CoFe-Mo LDH) catalyst is as follows: the CoFe-Mo LDH is prepared by a simple coprecipitation method. The CoFe-Mo LDH is used for a heterogeneous electrocatalytic sp 2 C–H activation and CO2 carboxylation. By changing the CoFe-Mo LDH intercalation of the CoFe-Mo LDH solvent environment, a series of mono-carboxylation and di-carboxylation products can be obtained, such as: in the case of benzene as a substrate and DMF as a solvent, a mono-carboxylation product benzoic acid is obtained; in the case of benzene as a substrate and MeCN as a solvent, a di-carboxylation product isophthalic acid is obtained. For the first time, the on-demand switching of the mono-carboxylation and di-carboxylation of phenyl substrates is realized, and this research not only provides a new heterogeneous electrocatalytic strategy to achieve the carbon neutralization target, but also successfully converts cheap and easily available chemicals into high-value and carbon chain growth carboxylic acids under mild conditions.

The application relates to the technical field of thin film surface treatment, in particular to a method for improving the adhesion between an aluminum oxide sputtering layer and a PET thin film, which comprises the following steps: S1, PET pretreatment: performing surface corona treatment on the PET thin film layer; S2, coupling agent coating: coating an amino silane coupling agent on the surface of the PET thin film layer treated in the step S1 to form a coupling agent layer; and S3, sputtering aluminum oxide: sputtering aluminum oxide on the surface of the coupling agent layer through a sputtering process to form an aluminum oxide sputtering layer. The application performs corona treatment on the surface of the PET thin film layer, so that polar groups such as hydroxyl and carboxyl are generated on the surface of the PET thin film layer, then the silane coupling agent is coated on the surface of the treated PET thin film layer, stable amide bonds are generated between the coupling agent and the PET thin film, dehydration condensation occurs between the coupling agent and the hydroxyl on the surface of the aluminum oxide sputtering layer to form covalent bonds, and the adhesion between the aluminum oxide sputtering layer and the PET thin film is improved through double bonding of the amide bonds and the covalent bonds.

In an iron (II) citrate monohydrate, identified by the formula FeC6H6O7-H2O ( Ferrous citrate monohydrate or iron citrate (II) monohydrate), obtained according to a particular production method, citric acid and elemental iron are bound in a molecular complex where the iron is agglomerated in the citrate which moves to a cyclic form and the iron is bound to the O groups of the carboxylic groups 1 and 3 through ionic bonds, forming two enantiomers, D and L (R and S), both perfectly water-soluble and highly assimilable by the human body. Formula (L) & Formula (D). With a different absorption mechanism from traditional iron molecules, said iron citrate monohydrate is usable in pharmaceutical and / or nutraceutical and / or food compositions, in particular in the treatment and prevention of iron deficiency anemias and in general of all diseases and disorders associated with iron deficiency. The effectiveness is proven by several examples.

The application provides a photochemical chemiluminescence detection reagent and a preparation method thereof, and a procalcitonin detection method. The photochemical chemiluminescence detection reagent comprises acceptor microspheres and donor microspheres; wherein the acceptor microspheres are carboxyl-modified acceptor microspheres, and the carboxyl is activated by sulfo-NHS / EDC and coupled with a procalcitonin antibody; and the donor microspheres are carboxyl-modified donor microspheres, and the carboxyl is activated by sulfo-NHS / EDC and coupled with a procalcitonin antibody. The photochemical chemiluminescence detection reagent has higher stability in various environments, can more accurately combine with target molecules, realizes more efficient detection and recognition, and enables the microspheres to more accurately capture and fix the target molecules, so as to perform subsequent luminescence reaction. The detection method has high sensitivity and a wide range, can be used as a detection reagent for diagnosing and identifying infectious diseases of individuals, and has application value.

The preparation of high-value-added aromatic carboxylic acids via CO2 carboxylation coupling through activation of the benzyl C-H bond in alcohols / amines is a green and sustainable pathway to achieve CO2 resource utilization and contribute to carbon neutrality. However, this field currently faces challenges such as poor catalyst selectivity, low CO2 activation efficiency, and a narrow substrate applicability range, making it difficult to meet practical application needs. To address this issue, this patent discovers that in a heterogeneous electrocatalytic system, cuprous selenide (V2), rich in selenium vacancies, can be used... Se -Cu 2‑x Using Se as the core catalyst, it can not only efficiently promote the synergistic activation of benzyl C-H bonds and CO2 carboxylation, significantly improving the overall catalytic activity of the reaction, but also achieve precise chemoselective carboxylation control for different types of substrates. Specifically, this V Se -Cu 2‑x Se electrocatalysts can efficiently and selectively activate the benzyl C-H bond in alcohols and subsequently induce CO2 carboxylation, exhibiting excellent chemoselectivity in the conversion of benzyl alcohol to mandelic acid and its derivatives. Simultaneously, they also demonstrate excellent catalytic performance for amines, selectively catalyzing the carboxylation of amine substrates such as benzylamine with CO2 to directionally generate phenylglycine and aromatic amine-derived carboxylates. Crucially, in addition to typical benzyl alcohol and benzylamine, the substrate applicability of this catalytic system can be extended to various alcohols and amine derivatives, realizing the carboxylation transformation from simple model substrates to diverse functional molecules, providing a new approach for the large-scale preparation of high-value-added aromatic carboxylates.

This invention belongs to the field of acyclic compound synthesis technology, specifically relating to a production process for 1,1-dimethyl-3-hydroxybutyl hydrogen peroxide. The production process includes the following steps: (1) preparing a metal salt solution A; preparing a solution B from 1,3,5-tris(4-carboxyphenyl)benzene; oxidizing carbon nanotubes to form carbon oxide nanotubes, and then preparing a suspension from molecular sieves, metal oxides, and carbon oxide nanotubes; (2) adding solution B to the suspension, continuing to add solution A for reaction, and after post-treatment, obtaining a catalyst precursor; (3) calcining the catalyst precursor in an inert atmosphere to obtain a catalyst; (4) activating the catalyst to catalyze the reaction of 2-methyl-2,4-pentanediol and hydrogen peroxide to obtain 1,1-dimethyl-3-hydroxybutyl hydrogen peroxide. This invention further improves the selectivity and yield of 1,1-dimethyl-3-hydroxybutyl hydrogen peroxide by designing the catalyst.

The present application relates to the technical field of multiphase flow monitoring, and particularly relates to an aggregation-induced emission material, a preparation method and application thereof, the preparation method comprising the following steps: mixing a conjugate, an electron donor and an additive, and reacting to obtain an aggregation-induced emission molecule; mixing the aggregation-induced emission molecule with an organic solvent to obtain a molecular solution; mixing particulate matter containing an active group with a solvent to obtain a particulate matter solution; mixing the molecular solution with the particulate matter solution, and reacting to obtain the aggregation-induced emission material; the electron donor comprises an amino-containing electron donor, a carboxyl-containing electron donor or a hydroxyl-containing electron donor; the active group in the particulate matter containing the active group comprises an amino group, a carboxyl group or a hydroxyl group.The technical scheme of the present application realizes dynamic migration tracking and quantitative analysis of the aggregation-induced emission material in a non-transparent porous medium, and solves the problems of poor penetration and strong background interference of traditional optical tracking technology in the non-transparent porous medium.

This application belongs to the field of biomedical technology and discloses an aromatic acetylenyl derivative, a method for coupling it with a thiol, and its application. The aromatic acetylenyl derivative has the following formula (1), where Ar is aryl or heteroaryl; X is -NH-; Y is -(C2H4-O)m-(CH2)s-(COO)h-A; A is selected from one of halogen, C1-C6 alkyl, trifluoromethyl, hydroxyl, methoxy, trifluoromethoxy, acetoxy, cyano, nitro, amino, methylamino, dimethylamino, sulfonamide, methanesulfonyl, methanesulfonamide, carboxyl, and ester, preferably hydroxyl, C1-C6 alkyl or amino; m, s, and h are integers from 0 to 20.

The application belongs to the field of oral products, and specifically discloses an oral product and a preparation method and application thereof. The oral product comprises the following components in percentage by mass: a curing agent 0.1-20%, a filler 5-80%, traditional Chinese medicine powder 0.2-60%, and plant essential oil 0.5-20%. The curing agent contains at least one functional group selected from a carboxyl group, an ester group and a hydroxyl group. The oral product in the application uses traditional Chinese medicine powder as a main component for refreshing the mind, and the plant essential oil is solidified by a curing agent and then mixed with the filler and the traditional Chinese medicine powder to prepare a natural, green, healthy and pleasant-smelling oral product for refreshing the mind. The oral product in the application not only solves the problem of unacceptable smell of traditional Chinese medicine, but also solves the problems of easy evaporation, yellowing and discoloration of natural plant essential oil through solidification of the plant essential oil. The prepared oral product still has a strong fragrance and a long-lasting refreshing effect after long-term storage.

A carbon dioxide concentrator including a first cathode electrode; a second anode electrode that is separately disposed from the first electrode; and at least one electrolyte liquid that is contained between the first electrode and the second electrode and that is present in contact with the first electrode and the second electrode, wherein the at least one electrolyte liquid contains: a compound represented by a following formula (1) or a salt thereof; and water,in the formula (1), R1 to R10 each independently represent a hydrogen atom, an alkyl group, a hydroxy group or a salt thereof, an alkoxy group, a nitro group, an amino group, a mercapto group, a cyano group, a halogen group, an aryl group, a sulfone group or a salt thereof, a carboxyl group or a salt thereof, a carbonyl group, a sulfonyl group, or a heteroaryl group.

This invention belongs to the field of cosmetic technology and discloses a skin care and hair care liquid composition of water-based polyurethane-10 and type III collagen. This invention combines water-based polyurethane-10 and type III collagen in a specific ratio, utilizing the residual NCO groups (or urea groups, carbamate groups) in polyurethane-10 to form a strong hydrogen bond cross-linking network with the amino and carboxyl groups in collagen molecules. This allows the collagen to firmly adhere to the skin or hair surface, while simultaneously softening the stratum corneum, resulting in a smooth skin feel and achieving multiple effects such as long-lasting moisturizing, improved elasticity, and wrinkle concealing.

This invention discloses a polyvinyl alcohol-modified multifunctional powder slump retainer and its preparation method. The preparation method is as follows: First, polyvinyl alcohol is etherified with p-halogenated benzoic acid to prepare a carboxyl-containing intermediate; second, the carboxyl-containing intermediate is amidated with an amino-terminated modified polyether to prepare a long-side-chain intermediate; then, the long-side-chain intermediate is activated by ortho-C-H oxidation with benzamide, and then coupled with a functional alkyne to form a ring to construct a functional group, thus preparing the target slump retainer; finally, the slump retainer is sliced ​​and pulverized using a slicer and a pulverizer, respectively, to obtain the powder slump retainer. This method uses widely available raw materials, and the preparation process is simple and safe; the product has a long shelf life; the product contains no anti-caking agents and other components, and has a fast dissolution rate, which can significantly reduce transportation costs; the product also has advantages such as antibacterial properties, reduced concrete shrinkage in the later stages, and high water retention; and the product has stable performance and can be stored for a long time.

The present invention provides a water electrolysis cell electrode, a water electrolysis cell membrane-electrode assembly comprising same, a manufacturing method therefor, and a water electrolysis cell. The water electrolysis cell electrode comprises: a catalyst; a polymer including a first repeating unit including one or more hydroxyl groups and a second repeating unit including one or more carboxyl groups; and a metal-based material bonded to the hydroxyl group of the first repeating unit and the carboxyl group of the second repeating unit.

The application provides a modified activated carbon for removing perchlorate in water for sheep farms and a preparation method thereof, relates to the field of water treatment, and the method carries out reaction on activated carbon in a citric acid aqueous solution, uniformly loads a carboxyl layer on the surface of the activated carbon, and obtains preliminarily modified activated carbon; carries out reaction on the preliminarily modified activated carbon in an alkaline polydimethyl diallyl ammonium chloride aqueous solution, and strong cation quaternary ammonium salt is adsorbed on the surface of the carboxyl layer through electrostatic action, thereby obtaining secondarily modified activated carbon; and carries out reaction on the secondarily modified activated carbon in a triethylenetetramine aqueous solution, so that triethylenetetramine molecules are further combined to the strong cation quaternary ammonium salt through electrostatic adsorption, thereby obtaining the modified activated carbon for removing perchlorate in water for sheep farms, the adsorption capacity of the activated carbon for solutes with negative charges is significantly enhanced, and the treatment efficiency of the overall farm environment on perchlorate is improved.

The application belongs to the technical field of wound dressings, and discloses a water-based gel dressing with antibacterial and scar prevention effects and a preparation method, wherein 3-fluoro-4-carboxyphenylboronic acid is introduced to graft chitooligosaccharide, a large number of catechol structures in tannic acid solution are combined with the phenylboronic acid bond to form a dynamic boron ester bond, and a network gel structure is formed by responding to the supermolecular forces such as hydrogen bonds, wherein the boron ester bond can be broken in response to the high ROS level of the wound microenvironment and the acidic environment caused by bacterial infection, so as to efficiently release celecoxib, a selective non-steroidal anti-inflammatory drug of cyclooxygenase-2, and the liposome of verteporfin is limited in volume and stays in the dressing for a longer time, so that the sustained and stable release can be maintained in the whole wound healing process, thereby achieving the effects of on-demand inflammation regulation and long-acting mechanical response regulation.

The present application relates to the preparation method of carboxyl endocyclic anhydride and the preparation product. The preparation method of compound of formula (II) comprises the following steps: reacting compound of formula (I) with a cyclization reagent to generate compound of formula (II) and acid, and using an epoxide compound as an acid scavenger. The present application is a new synthesis method of carboxyl endocyclic anhydride, which has the advantages of low cost, low requirement for reagents, site and equipment, mild conditions, wide substrate application range, high functional group tolerance, recyclable solvent and other high value-added by-products in the synthesis route, less waste liquid discharge, easy scale-up, high industrial and academic value, and the like, and can greatly promote the rapid large-scale production and application of polyamino acid, polyhydroxy acid (polyester), polymercaptan acid (polythioester) and the like.

This invention relates to the field of aqueous zinc battery separator modification technology, and particularly to a method for preparing and applying a polyacrylic acid modified separator with synergistic regulation of positive and negative electrodes. The method involves dissolving polyacrylic acid in water to form a homogeneous solution, then adding it dropwise to the separator surface and drying it to obtain the polyacrylic acid modified separator. The carboxyl functional groups in the polyacrylic acid can interact with hydrated zinc ions during battery operation, reconstructing the ion-water molecule microenvironment within the separator, promoting directional and uniform zinc ion deposition and interfacial desolvation, and inhibiting dendrite growth, corrosion, and hydrogen evolution side reactions at the zinc negative electrode. Simultaneously, the modified layer can mitigate local pH fluctuations at the positive electrode interface, stabilize the positive electrode interface environment, and reduce Mn. 3+ The disproportionation reaction and the formation of the byproduct ZnMn2O4 lead to synergistic stabilization of the positive and negative electrodes. This separator has advantages such as simple preparation process, low cost, and ease of large-scale preparation, and can significantly improve the coulombic efficiency, rate performance, and long-cycle stability of aqueous zinc-manganese batteries.

The application provides a negative electrode material and a preparation method thereof, a negative electrode sheet and a preparation method thereof, and a battery. The negative electrode material provided by the application comprises carboxyl-modified silicon monoxide and hydroxyl-modified metal carbide, and the mass ratio of the carboxyl-modified silicon monoxide to the hydroxyl-modified metal carbide is (1-3):1. The negative electrode material provided by the application not only utilizes the carboxyl in the carboxyl-modified silicon monoxide and the hydroxyl in the hydroxyl-modified metal carbide to easily generate hydrogen bonds to be connected with each other, enhances the cohesion of the negative electrode material, and effectively alleviates the expansion of the silicon negative electrode material during charging and discharging, but also utilizes the cooperation of the carboxyl-modified silicon monoxide and the hydroxyl-modified metal carbide to improve the conductivity and increase the fast-charging capacity of the battery.