53 results about "Silibinin" patented technology

The invention discloses a preparation method of an oral liver protection composition containing ergothioneine, and relates to the technical field of ergothioneine application. The oral liver protection composition containing the ergothioneine is prepared from the following components in parts by mass: 0.5 to 5 parts of the ergothioneine, 10 to 30 parts of silibinin, 20 to 50 parts of a phospholipid complex, 5 to 15 parts of a liver targeting carrier, 2 to 8 parts of a disintegrating agent, 1 to 5 parts of an adhesive and 2 to 4 parts of an antioxidant. Free radicals are efficiently captured through a polycyclic conjugated pi electron system of the antioxidant, a hydrogen bond network is formed by a heteroatom bridging effect of the antioxidant, a galactose group of the liver targeting carrier and the disintegrating agent, and the stability of the system is synergistically improved; the phospholipid complex is embedded with a hydrophobic drug and a hydrophilic carrier, and the drug is accurately delivered to the liver by combining the specific recognition capability of the liver targeting carrier; the ergothioneine and the silybin form a bidirectional synergistic liver protection mechanism by removing reactive oxygen free radicals and regulating and controlling cell signal channels respectively.

The invention belongs to the technical field of health-care food, and particularly relates to a composition and oral drops with the effects of dispelling the effects of alcohol, protecting the liver and relieving hangover as well as a preparation method and application of the composition and the oral drops. The invention provides a composition taking silybin eutectic crystal, curcumin eutectic crystal, ampelopsis grossedentata extract, pyrroloquinoline quinone disodium salt, reduced glutathione, alpha-ketoglutaric acid, vitamin, hericium erinaceus extract, frankincense extract, licorice extract and the like as main active ingredients, and the composition is subjected to scientific formula screening and functional verification, and has the advantages that the composition has the obvious curative effect, and the curative effect is obvious; the traditional Chinese medicine composition can effectively improve the metabolism of ethanol, protect liver and gastric mucosa, and is helpful for relieving hangover-related symptoms such as fatigue, thirst, sleepiness, headache, dry mouth, stomachache, nausea, hypomnesis, inattention and the like.

The invention discloses a composition capable of quickly dispelling the effects of alcohol and relieving moderate and mild fatty liver and application of the composition, and particularly relates to the technical field of health care products. The composition comprises the silybum marianum extract, the schisandra chinensis extract, the globe artichoke extract and the 1, 6-fructose diphosphate and cyclodextrin-clathrated silybum marianum extract as raw materials, on one hand, the bioavailability of the product is improved, the taste of the product is better, and the taste of the clathrated product is improved due to the fact that silybin is very bitter and cyclodextrin has a shielding property; and on the other hand, the FDP and the three plant extracts have a synergistic effect, and the combined composition can achieve the effects of quickly dispelling the effects of alcohol and relieving moderate and mild fatty liver.

The invention discloses an application of silibinin in enhancing the immunomodulatory function of stem cells, and relates to the technical field of biological medicines. The silybin is applied to the composition for enhancing the immunoregulation function of the stem cells, the composition comprises the silybin and umbilical cord-derived mesenchymal stem cells, and the immunoregulation function of UC-MSCs is enhanced by adjusting the interaction of ICOS / ICOSL axes based on the combined action of the silybin and the umbilical cord-derived mesenchymal stem cells. The silybin disclosed by the invention is competitively combined with the ICOS, so that the interaction of the ICOS / ICOSL is blocked, and the immune regulation function of the umbilical cord-derived mesenchymal stem cells is remarkably enhanced; therefore, the UC-MSCs show a stronger immunosuppression effect in both in-vitro and in-vivo experiments; silybin not only acts on an ICOS / ICOSL axis, but also inhibits secretion of inflammatory factors through a PI3K / AKT signal channel, so that a multi-mechanism synergistic treatment effect is achieved.

The invention belongs to the technical field of biology, and discloses application of DVM nanoparticles in preparation of products for treating and / or preventing alcoholic liver diseases, the DVM nanoparticles contain gallic acid derivatives VM and dihydromyricetin; the mass ratio of the gallic acid derivative VM to the dihydromyricetin is 1: 3; in alcohol-induced HepG2 cells, the DVM nanoparticles can better reduce apoptosis of hepatocytes and generation of ROS, improve ADH activity, reduce AST and ALT activities in the cells and improve the hangover alleviating ability in mice, and have a more excellent liver protection effect compared with gallic acid and a positive drug silibinin.

The invention discloses a medicinal and edible composition which is characterized by comprising the following components in parts by weight: 15-20 parts of a hovenia dulcis thunb extract, 10-15 parts of a turmeric extract, 8-12 parts of a schisandra chinensis extract, 5-8 parts of a globe artichoke extract, 6-10 parts of a ganoderma lucidum spore powder extract and 0.5-1 part of a silibinin extract. According to the composite composition prepared by the invention, ethanol metabolism key enzyme (ADH / ALDH) is activated by multiple targets, acetaldehyde removal is accelerated, and a hepatocyte repairing function is supplemented, so that alcohol metabolism after drinking is accelerated, and damage of alcohol to a human body is reduced.

The utility model relates to the field of silibinin production, and discloses a silibinin granulator with a dustproof mechanism, which comprises a vertical frame and a lifting motor, and the dustproof mechanism is mounted in the vertical frame. According to the silybin granulator with the dustproof mechanism, the case, the lifting motor, the threaded column, the threaded sleeve, the movable plate, the pressing plate and the top cover are arranged, before the granulator works, the lifting motor is started at the position of the control case according to the height of a material receiving container, the lifting motor drives the threaded column to rotate, and therefore the threaded sleeve and the movable plate are driven to descend; the whole outer barrel descends until the pressing plate is pressed into the top of the material receiving container without a gap, at the moment, the discharging opening is sealed in the material receiving container, and the upper portion of the top of the outer barrel is sealed through the top cover, so that the silybin raw materials cannot be scattered from the upper portion or the lower portion, the device is suitable for the material receiving containers of various sizes, personnel are prevented from inhaling silybin powder, raw material waste is reduced, and the production cost is reduced. The workload of later cleaning is reduced, and the problem that raw material dust is scattered is solved.

The invention provides a compound peptide beverage capable of dispelling effects of alcohol and protecting liver as well as a preparation method and application thereof. The compound peptide beverage is prepared from hovenia dulcis thunb oligopeptide, walnut peptide, antioxidant peptide, energy release auxiliary peptide, ethanol dehydrogenase activating peptide, silibinin-serine chelate, an electrolyte poising agent, alginic acid oligosaccharide and purified water. Wherein the antioxidant peptide is prepared from cordyceps militaris, sea-buckthorn and sunflower disc through mixed enzymolysis, the energy release auxiliary peptide is prepared from carnosine and arginine succinic acid peptide through microbial fermentation, and the ethanol dehydrogenase activating peptide is prepared from marine shellfish collagen through fermentation. The composite peptide beverage shows excellent functions of dispelling the effects of alcohol and protecting the liver, and can be used for developing medicinal products or functional foods for dispelling the effects of alcohol and protecting the liver. Through precise compatibility and an innovative process technology, the product constructs a unique solution for dispelling the effects of alcohol and protecting the liver, and has outstanding performance in the aspects of improving the alcohol metabolism efficiency and relieving liver injury.

The application discloses a plant extraction compound for reducing blood pressure, a preparation method and application thereof. The compound is composed of high-purity silybin extract and a specific fusion polypeptide through molecular self-assembly. The sequence of the fusion polypeptide is shown in sequence SEQ ID NO:1, which innovatively integrates cell membrane penetration function, angiotensin II receptor 1 antagonism function and hydrophobic drug binding function. The core of the application is that through polypeptide-mediated active targeting, silybin is accurately delivered to the diseased blood vessel area, and the double synergistic mechanism of upstream ACE inhibition and downstream receptor blocking of the renin-angiotensin-aldosterone system is realized. In-vivo pharmacodynamic experiments prove that compared with single components, the compound can produce more significant and persistent antihypertensive effect, and can effectively reverse myocardial hypertrophy and fibrosis caused by hypertension, and show excellent synergistic therapeutic effect and target organ protection ability.

The application discloses a capsule for assisting in protecting chemical liver injury and a preparation method thereof, and belongs to the technical field of health-care food. The capsule is composed of curcuma longa extract 100g, silybum marianum extract 70g, schisandra chinensis extract 60g, microcrystalline cellulose 109.5g, silicon dioxide 7g and magnesium stearate 3.5g, and 1000 capsules are taken as a unit. The curcuma longa extract contains curcumin, the content of which is greater than or equal to 10% (10:1), the silybum marianum extract contains silybin, the content of which is greater than or equal to 20% (25:1), and the schisandra chinensis extract contains schisandrin, the content of which is greater than or equal to 1.5% (12.5:1). The three kinds of plant extracts are scientifically compounded, and the effects of antioxidation, anti-inflammation, liver cell membrane protection and bile secretion regulation are synergistically exerted. Through systematic screening of the types and dosages of the filling agent, the flow agent and the lubricant, the technical problems of poor flowability of the mixed plant extract powder, large filling difference and easy jamming are solved.

The invention discloses a preparation method of a silybin nanostructure lipid carrier, which comprises the following steps: step 1, heating ethanol and silybin in a water bath, and uniformly stirring to obtain a silybin solution; dispersing a co-emulsifier in deionized water, and heating and stirring in a water bath to obtain a water phase; step 2, adding solid lipid, liquid lipid, a main emulsifier and a co-emulsifier into the silibinin solution, heating for melting, and uniformly stirring to obtain an oil phase; under the condition of constant-temperature stirring, transferring the oil phase into the water phase, mixing the solution, and shearing to obtain a coarse dispersion system; and 3, heating the coarse dispersion system to concentrate the coarse dispersion system into an emulsion. The silibinin nanostructure lipid carrier prepared by the invention can improve the solubility of silibinin, and is good in characterization performance; the preparation cost is controllable, and macro preparation can be realized; the silybin nano-structure lipid carrier can be used for effectively preventing acute liver injury caused by CCl4 of animals.

The invention relates to a silibinin derivative as well as a preparation method and application thereof, and belongs to the technical field of chemistry. The invention relates to a silibinin derivative, which is 6-sulfonated silibinin sodium sulfonate, the chemical name of the silibinin derivative is 2, 3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-6-(3, 5, 7-trihydroxy-4-oxo benzopyran-2-yl) benzodioxane-6-sodium sulfonate, the molecular formula of the silibinin derivative is C25H21NaO13S, and the molecular weight of the silibinin derivative is 584.49. Sulfonic acid groups with hydrophilicity are introduced into different parts of the silibinin to prepare different types of silibinin sodium sulfonate, so that the solubility of the silibinin sodium sulfonate in water is enhanced, the pharmacokinetic characteristics of the silibinin are improved from the pharmacokinetic level, the affinity and biological activity of the silibinin to organisms are improved, and the application prospect of the silibinin sodium sulfonate is widened. The compound is further prepared into an injection for clinical treatment, and has important clinical drug treatment value.

The invention relates to the technical field of medicine, in particular to a recombinant human XVII type collagen / silibinin nanoemulsion and a preparation method and application thereof, and the nanoemulsion is prepared from the following components in percentage by weight: 0.2%-1.5% of recombinant human XVII type collagen, 0.5% of silibinin, 1%-10% of lecithin, 1%-10% of glycerol, 3%-15% of Tween 80, 2%-8% of PEG400 and the balance of pure water. The prepared nano-emulsion is uniform in size and high in stability, irritation is effectively reduced, skin light damage can be remarkably repaired, the synergistic effect of oxidation resistance and barrier repair is achieved, UVB-induced oxidative stress, inflammatory response and skin structure damage are inhibited in multiple ways, and the nano-emulsion has a good prospect in application of skin UVB light damage repair.

The embodiment of the invention provides a composition for promoting desmogranulocytin expression, a skin care preparation and application. The composition and the skin care preparation can be used for promoting DSG1 expression. The composition for promoting the expression of desmogranulocytin comprises: silibinin; and a compound of formula (I); formula (I): # imgabs0 #

The invention discloses application of silibinin combined stem cells in treatment of rheumatoid arthritis, and relates to the technical field of biological medicines. The silybin is applied to the composition for treating the rheumatoid arthritis, the composition comprises umbilical cord-derived mesenchymal stem cells and the silybin, and the concentration of the silybin is 10-200 [mu] mol / L. The silybin and the umbilical cord-derived mesenchymal stem cells are combined for use, and the release of inflammatory factors can be remarkably inhibited by regulating the interaction of ICOS / ICOSL axes, so that the symptoms of rheumatoid arthritis are effectively relieved; due to the synergistic effect, the treatment effect is enhanced, and the limitation of a single treatment means is reduced; the silybin is used as a flavonoid compound extracted from traditional Chinese medicines, and has the characteristics of good safety and low side effect.

The invention discloses a health-care product composition for blood purification and liver and gall detoxification as well as a preparation method and application thereof, and belongs to the technical field of health-care products. The health-care product composition for blood purification and liver and gall detoxification provided by the invention is prepared from the following components in parts by mass: 10 to 40 parts of fermented barley leaf powder, 5 to 20 parts of a silibinin phospholipid complex, 5 to 15 parts of a dandelion extract, 5 to 15 parts of an artichoke extract, 5 to 10 parts of curcumin, 2 to 8 parts of alpha-lipoic acid and 1 to 5 parts of N-acetylcysteine. According to the composition, a four-dimensional synergistic purification system of intestinal adsorption purification, liver biochemical detoxification, bile excretion promotion and whole-course antioxidant protection is constructed, and the components are mutually promoted and enhanced at different time and space and different target spots to synergistically achieve the double effects of blood purification and liver and gallbladder detoxification.

The application provides a silibinin directional thin-layer molecular imprinting silica ball and a preparation method and application thereof, and belongs to the technical field of natural product separation and purification. The silibinin directional thin-layer molecular imprinting silica ball is prepared by constructing a directional recognition thin layer on the surface of silica microspheres through four steps of silanization, amidation, esterification and thin-layer polymerization. The silibinin directional thin-layer molecular imprinting silica ball can specifically recognize the meta-diol structure of silibinin by virtue of the electron-deficient boron atom of phenylboronic acid, and can form a stable covalent borate ester bond under weak alkaline conditions, and the bond can be reversibly broken under acidic conditions, so that the directional capture and mild elution of silibinin are realized. In combination with the precise site replication of the thin-layer imprinting, silibinin and other flavone impurities can be efficiently separated, the separation efficiency is improved by nearly 90% compared with traditional macroporous adsorption resin, and the purity of silibinin after separation can reach more than 95%.

The invention belongs to the technical field of pharmaceutical compositions, and particularly relates to a composition for improving the bioavailability of silibinin, a preparation method and application. Highly-dispersed micro-powder particles are formed by mixing the silybum marianum extract and the specific plant extracts (the liquorice extract, the radix puerariae extract and / or the gynostemma pentaphylla extract) according to a specific proportion and carrying out compressed air suspension, dispersion and granulation, and on the premise that an organic solvent and a surface active agent are not added, the micro-powder particles can be uniformly dispersed, so that the preparation process is simplified, and the preparation cost is reduced. According to the silybum marianum extract, the dissolution rate and bioavailability of silybin in the silybum marianum extract are remarkably improved, the label is clean, the preparation method is simple, and the silybum marianum extract has a good application prospect.

The invention discloses application of silibinin in preparation of a medicine for treating autoimmune hepatitis, and belongs to the field of biological medicine application. The silybin has a good liver protection effect, and a pathological experiment combined with a related mouse disease model in development of autoimmune liver injury pathogenesis research finds that the silybin can well relieve inflammation caused by the autoimmune liver injury, so that the silybin can replace or assist a traditional steroid hormone therapy, and the silybin has a good application prospect. And side effects caused by traditional therapy are reduced.

The invention belongs to the technical field of animal immunopotentiators, and particularly relates to weaned piglet immunoregulation nanoparticles with liver targeting and a preparation method thereof.The preparation method comprises the following steps that S1, galactomannan is added into deionized water, butyl glyceride is added after stirring and dissolving, the pH is adjusted, a reaction is conducted under shielding gas, and a mixture is obtained; after the reaction is finished, dialyzing, purifying and freeze-drying to obtain butyl glyceride modified galactomannan; s2, dissolving the butyl glyceride modified galactomannan prepared in S1 into a buffer solution, stirring until the butyl glyceride modified galactomannan is dissolved, dropwise adding a silibinin ethanol solution into the buffer solution, and performing ultrasonic reaction to obtain silibinin-galactomannan self-assembled nanoparticles; and S3, adding a cross-linking agent into the silibinin-galactomannan self-assembled nanoparticles, carrying out a cross-linking reaction, then carrying out dialysis purification, and carrying out freeze drying so as to obtain the immunoregulation nanoparticles. According to the invention, silibinin is used as an immunomodulator, and based on the natural recognition characteristics of galactomannan and mannose receptors on the surfaces of weaned pig liver kuhn cells and dendritic cells, the nano packaging efficiency and stability of galactomannan to silibinin are enhanced by using the hydrophobic characteristic of butyl glyceride; the invention constructs a novel immunomodulator with weaned piglet liver targeting.

This invention discloses the use of silybin derivatives or their stereoisomers, or pharmaceutically acceptable salts, with the structure shown in Formula I in the preparation of medicaments for the prevention and / or treatment of depressive disorders; R1, R2, R3, R4, R5, and R6 are independently selected from hydrogen, methyl, and methyl groups. Compared with silybin alone, royal jelly acid, or a combination of silybin and royal jelly acid, the silybin derivatives of this invention exhibit more significant effects on mouse models of depression induced by chronic social frustration stress and chronic restraint stress, even with significantly reduced dosage, and can be used to prepare medicaments for the treatment of depressive disorders.

The invention discloses an atractydin dispersion solubilizing method based on a deep neural network and strategy optimization, and aims to solve the problems that key quality attributes in online monitoring and closed-loop control in the preparation process are difficult to stably reach the standard, and batch difference and equipment safety are difficult to consider at the same time. According to the invention, uncertainty prediction is carried out by combining a multi-mode cross-attention depth model with energy sensing position coding and sensor reliability weighting and controlling affine and a Shenchang differential equation with physical constraints, and self-adaptive parameter adjustment of a rolling optimization driving actuator is predicted and controlled by a double-time-domain model of a probabilistic security constraint and control barrier function. The technical effects of online accurate prediction and stable standard reaching of key quality attributes (including the median diameter of the particle size, the polydispersity index, the electrokinetic potential and the dissolution curve), smooth action, energy consumption reduction and process and equipment safety control are achieved.

The invention relates to the field of medicines, and provides silibinin freeze-dried powder and a preparation method thereof. The method comprises the following steps: balancing a second solution for 30 minutes at the temperature of 4 DEG C, cooling to-50 DEG C at the cooling rate of 1 DEG C / min, and keeping for 2-5 hours to obtain a pre-frozen product; putting the pre-frozen product into a vacuum device with the vacuum degree of 0.01-0.5 mbar and the temperature of-35 DEG C to-20 DEG C, and standing for 10-20 hours to sublimate free water in the pre-frozen product, so as to obtain a first dried product; the vacuum degree of the vacuum device is kept at 0.01-0.5 mbar, the temperature is raised to 10-30 DEG C at the temperature raising rate of 0.1-0.3 DEG C / min, the temperature is kept for 4-8 h, nitrogen is charged, and the silibinin freeze-dried powder is obtained. The freeze-dried powder prepared by the invention is high in encapsulation efficiency, high in redissolution rate and good in stability, and is beneficial to improving the medication safety.

The invention discloses application of silybin A in preparation of a medicine for treating idiopathic pulmonary fibrosis, and the technical scheme provided by the invention shows that silybin A inhibits a TGF-beta1 signal transduction pathway by degrading TGF-betaRII, can reduce the collagen content of the lung of an IPF mouse, improve the alveolar structure of the mouse and reduce the levels of HYP, TGF-beta1 and TNF-alpha, and can be used for preparing a medicine for treating idiopathic pulmonary fibrosis. Finally, the anti-fibrosis treatment effect on the IPF mouse is achieved.

The invention discloses a silybin B molecular imprinting template as well as a preparation method and a use method thereof, and belongs to the technical field of molecular imprinting, and the preparation method comprises the following steps: adding silybin B, N-isopropylacrylamide, ethylene glycol dimethacrylate and polyvinylpyrrolidone into acetonitrile, uniformly dispersing, then adding azodiisobutyronitrile, and uniformly stirring to obtain the silybin B molecular imprinting template. The preparation method comprises the following steps: reacting under the protection of nitrogen, washing the reacted insoluble substance with a mixture of methanol and acetic acid, and drying to obtain polymer microspheres which are used as the silibinin B molecular imprinting template. Molecularly imprinted polymer microspheres are prepared through a free radical polymerization reaction, the formed microspheres are uniform in structure and not prone to agglomeration, the obtained polymer microspheres have the temperature-sensitive characteristic and can adsorb silybin B molecules at the room temperature, the polymer microspheres are subjected to phase transformation after being heated, the polymer structure shrinks, silybin B is released, and the silybin B can be effectively adsorbed. Silybin B molecules can be efficiently separated by utilizing selective adsorption and temperature-sensitive characteristic desorption of a molecular imprinting technology on the silybin B.

The invention provides a purification method of silymarin and a preparation method of high-purity silybin, and relates to the technical field of silybin. According to the method, one of the ethanol water solution, the isopropanol water solution and the ethanol-ethyl acetate solution is used as the purification solvent for purifying the silymarin, so that a silybin crude product with relatively high purity can be obtained. And dissolving the silybin crude product with hot isopropanol, concentrating, adding hot water, and precipitating to separate out the silybin, thereby obtaining the high-purity silybin with the purity not lower than 99%. The method is simple and suitable for industrial production.

The present invention relates to a silybin derivative, a preparation method therefor and the use thereof, belonging to the technical field of chemistry. In the present invention, by means of introducing a hydrophilic sodium sulfonate group into silybin, silybin is sulfonated to prepare a new compound having a good water solubility, i.e. sodium silybin sulfonate. This increases the solubility of silybin in water, improves the pharmacokinetic characteristics of silybin from a pharmacokinetic perspective, and increases the affinity therewith for organisms and the bioactivity of silybin. The compound can be formulated into an injection for use in clinical treatment, providing a better administration route. Sodium silybin sulfonate has incomparable advantages over silybin, and thus also has broad significance and great therapeutic value in clinical applications.

The invention discloses application of a mast cell stabilizer in preparation of a product for controlling transmission of arthroviruses. The invention provides application of a mast cell stabilizer in preparation of a product for controlling transmission of arthroviruses. The invention finds that mosquito exposure before repeated infection can significantly promote the transmission of flavivirus in the natural state, and finds that the mast cell stabilizer can inhibit the recruitment of virus susceptible cells and inhibit the transmission of flavivirus in the natural state. Mstoma cell stabilizers, such as silibinin, may be used in novel arthrovirus propagation blocking methods.

The invention discloses a traditional Chinese medicine composition for preventing and treating liver diseases as well as a preparation method and application thereof. The traditional Chinese medicine composition comprises ginseng, bighead atractylodes rhizome, poria cocos, liquorice, pinellia ternate and pericarpium citri reticulatae. The traditional Chinese medicine composition disclosed by the invention has an improvement effect on metabolism-related fatty liver diseases, and the treatment effects of the traditional Chinese medicine composition and the metabolism-related fatty liver diseases are almost equivalent compared with those of currently recognized liver protection medicine silibinin.

The invention relates to the field of medical instruments, the field of medical or dressing preparations, the technical field of biological medicine manufacturing and the technical field of preparation, in particular to a supramolecular anti-aging composition suitable for people with sensitive skin and a preparation method and application of the supramolecular anti-aging composition. Active ingredients, an inclusion material, an emulsifier and a solvent; the active ingredients are prepared from silymarin, silanetriol and phytol; the silymarin comprises silibinin, silymarin and silymarin; the silymarin comprises silybin, silymarin and silymarin; the inclusion material comprises at least one of hydroxypropyl-alpha-cyclodextrin and hydroxypropyl-beta-cyclodextrin, and the inclusion material comprises at least one of hydroxypropyl-alpha-cyclodextrin and hydroxypropyl-beta-cyclodextrin; the emulsifying agent is prepared from at least one of oleyl alcohol polyether-20, Tween 80 and PPG-13-decyl tetradecyl alcohol polyether-24; the solvent comprises water and polyhydric alcohol. The composition provided by the invention has excellent anti-aging effect and stability, has a good effect of reducing allergy, and is suitable for sensitive people.