69 results about "Silibinin" patented technology

The invention discloses a preparation method of an oral liver protection composition containing ergothioneine, and relates to the technical field of ergothioneine application. The oral liver protection composition containing the ergothioneine is prepared from the following components in parts by mass: 0.5 to 5 parts of the ergothioneine, 10 to 30 parts of silibinin, 20 to 50 parts of a phospholipid complex, 5 to 15 parts of a liver targeting carrier, 2 to 8 parts of a disintegrating agent, 1 to 5 parts of an adhesive and 2 to 4 parts of an antioxidant. Free radicals are efficiently captured through a polycyclic conjugated pi electron system of the antioxidant, a hydrogen bond network is formed by a heteroatom bridging effect of the antioxidant, a galactose group of the liver targeting carrier and the disintegrating agent, and the stability of the system is synergistically improved; the phospholipid complex is embedded with a hydrophobic drug and a hydrophilic carrier, and the drug is accurately delivered to the liver by combining the specific recognition capability of the liver targeting carrier; the ergothioneine and the silybin form a bidirectional synergistic liver protection mechanism by removing reactive oxygen free radicals and regulating and controlling cell signal channels respectively.

The invention discloses a method for preparing a double-nutrition fat substitute based on soybean protein-silibinin compound high internal phase emulsion, and belongs to the technical field of food processing. The method comprises the following steps: respectively preparing a soybean protein solution and a silybin solution to form a soybean protein-silybin compound, dissolving resveratrol into an oil phase by virtue of an ultrasonic dispersion means, and homogenizing at a high speed to prepare a soybean protein-silybin compound high internal phase emulsion as the double-nutrition fat substitute. The milk is green, healthy, low in cost and environment-friendly, and caters to the consumption requirements of vegetarians, people with specific diet requirements and people complying with religious diet restrictions, and the addition of the silibinin improves the antioxidant activity and stabilizes the emulsion interface, and endows the emulsion with antibacterial performance. Meanwhile, the resveratrol carried by the emulsion enables the fat substitute to have potential health benefits and nutritional value. The method for preparing the double-nutrition fat substitute which is similar to real fat in texture and healthy by packaging natural polyphenol through the soybean protein-silibinin high-internal-phase emulsion provides a wider development thought for application of the high-internal-phase emulsion; and the method is beneficial exploration of using the emulsion based on the vegetable protein as an effective substitute of saturated fat in various foods.

The invention relates to the technical field of preparation of silibinin, and discloses a rapid extraction and purification device and process for silibinin. A filter disc; the assembling rod is rotationally mounted on the filtering disc, and an extrusion roller used for extruding the scattered raw materials is rotationally mounted on the assembling rod; and a transmission assembly. After the filter disc ascends, the assembling rod is in butt joint with the stirring shaft through the clamping assembly, the stirring shaft rotates to drive the assembling rod to synchronously rotate, the transmission assembly drives the scattering wheels to rotate, the scattering wheels can scatter raw materials on the filter screen, and then the extrusion roller rotates to the position to roll the scattered raw materials; according to the silybin extraction device, a solution infiltrated in a silybum marianum raw material can be extruded after filtration, a solution which is most fully fused with the silybum marianum raw material is fully extracted, the problems that the solution is wasted due to the fact that the solution is directly removed after filtration, and silybin cannot be fully extracted are solved, and the extraction efficiency of the silybin is greatly improved.

The invention belongs to the technical field of health-care food, and particularly relates to a composition and oral drops with the effects of dispelling the effects of alcohol, protecting the liver and relieving hangover as well as a preparation method and application of the composition and the oral drops. The invention provides a composition taking silybin eutectic crystal, curcumin eutectic crystal, ampelopsis grossedentata extract, pyrroloquinoline quinone disodium salt, reduced glutathione, alpha-ketoglutaric acid, vitamin, hericium erinaceus extract, frankincense extract, licorice extract and the like as main active ingredients, and the composition is subjected to scientific formula screening and functional verification, and has the advantages that the composition has the obvious curative effect, and the curative effect is obvious; the traditional Chinese medicine composition can effectively improve the metabolism of ethanol, protect liver and gastric mucosa, and is helpful for relieving hangover-related symptoms such as fatigue, thirst, sleepiness, headache, dry mouth, stomachache, nausea, hypomnesis, inattention and the like.

The invention relates to a silybin derivative as well as a preparation method and application thereof, and belongs to the technical field of chemistry. According to the invention, a hydrophilic sodium sulfonate group is introduced into the silibinin, and the silibinin is sulfonated to prepare a novel compound, namely the silibinin sodium sulfonate with good water solubility, so that the solubility of the silibinin sodium sulfonate in water is enhanced, the pharmacokinetic characteristics of the silibinin are improved from the pharmacokinetic aspect, the affinity and biological activity of the silibinin to organisms are improved, and the application prospect of the silibinin sodium sulfonate is widened. The silybin can be prepared into an injection for clinical treatment, provides a more excellent administration route, has the superiority incomparable with that of silybin, and has wide significance and huge treatment value in clinical application.

The invention provides a silibinin mixed micelle injection as well as a preparation method and application thereof, and belongs to the technical field of pharmaceutical preparations. The cholate / lecithin mixed micelle system constructed by adopting specific cholic acid and phospholipid has good stability, can be well compatible with the silibinin so as to well encapsulate the silibinin, can obviously improve the solubility of the silibinin, has higher safety under the condition of ensuring the stability of the silibinin, and can be used for preparing a medicine for treating the silibinin. Therefore, the bioavailability of the silibinin is greatly improved. According to the invention, a shearing dispersion method is adopted to prepare the mixed micelles, and the mixed micelles with high drug loading capacity, clarification and good stability for silibinin are formed by destroying and shearing the raw and auxiliary materials in a molecular level, so that the mixed micelles have better physical and chemical stability, the drug quality is easier to control, the process is more simplified, the clinical medication is safer and the cost is lower; and the accessibility of the medicine is improved.

The invention discloses an application of silybin in preparation of a retinol transdermal absorption enhancer, and silybin can increase the retention volume of retinol in skin so as to improve the transdermal absorption capacity of the skin to retinol. The invention also provides a skin external preparation which comprises retinol and a transdermal absorption enhancer, the transdermal absorption enhancer is silibinin.

The present invention relates to the application of a silymarin pharmaceutical composition in the preparation of a drug for treating fatty liver disease, and belongs to the field of medical technology. The present invention provides the application of a pharmaceutical composition in the preparation of a drug for preventing and / or treating fatty liver disease, wherein the active ingredient of the pharmaceutical composition comprises a 7-KDCA regulator; the 7-KDCA regulator comprises silymarin, or the 7-KDCA regulator comprises silybin, silybin, silybinin and / or isosilybin; the silybin comprises silybin A and / or silybin B; the isosilybin comprises isosilybin A and / or isosilybin B. Studies have shown that the pharmaceutical composition can effectively and safely treat fatty liver disease at a low dose, has anti-inflammatory activity, and has a mimetic nerve growth factor activity, and has great application prospects in the preparation of drugs for preventing and / or treating fatty liver disease, anti-inflammatory, and preventing and / or treating Alzheimer's disease.

The invention provides a quick-acting anti-alcoholism composition and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The quick-acting anti-alcoholism composition disclosed by the invention is prepared from the following components in parts by weight: 35-45 parts of a silibinin extract, 5-15 parts of a curcumin extract, 5-15 parts of a radix puerariae extract, 1-5 parts of piperine and 1-5 parts of corn oligopeptide. The biocompatibility and the absorption speed are increased by combining and proportioning the effective substances and preparing the nano-liposome, so that the aim of quickly dispelling the effects of alcohol is fulfilled.

The invention discloses a composition capable of quickly dispelling the effects of alcohol and relieving moderate and mild fatty liver and application of the composition, and particularly relates to the technical field of health care products. The composition comprises the silybum marianum extract, the schisandra chinensis extract, the globe artichoke extract and the 1, 6-fructose diphosphate and cyclodextrin-clathrated silybum marianum extract as raw materials, on one hand, the bioavailability of the product is improved, the taste of the product is better, and the taste of the clathrated product is improved due to the fact that silybin is very bitter and cyclodextrin has a shielding property; and on the other hand, the FDP and the three plant extracts have a synergistic effect, and the combined composition can achieve the effects of quickly dispelling the effects of alcohol and relieving moderate and mild fatty liver.

The invention discloses an application of silibinin in enhancing the immunomodulatory function of stem cells, and relates to the technical field of biological medicines. The silybin is applied to the composition for enhancing the immunoregulation function of the stem cells, the composition comprises the silybin and umbilical cord-derived mesenchymal stem cells, and the immunoregulation function of UC-MSCs is enhanced by adjusting the interaction of ICOS / ICOSL axes based on the combined action of the silybin and the umbilical cord-derived mesenchymal stem cells. The silybin disclosed by the invention is competitively combined with the ICOS, so that the interaction of the ICOS / ICOSL is blocked, and the immune regulation function of the umbilical cord-derived mesenchymal stem cells is remarkably enhanced; therefore, the UC-MSCs show a stronger immunosuppression effect in both in-vitro and in-vivo experiments; silybin not only acts on an ICOS / ICOSL axis, but also inhibits secretion of inflammatory factors through a PI3K / AKT signal channel, so that a multi-mechanism synergistic treatment effect is achieved.

The invention relates to the technical field of nano medicines, in particular to a response type nano drug delivery system as well as preparation and application thereof. The nano drug delivery system is formed by chemically combining methoxy polyethylene glycol and silibinin by using an active oxygen response bond ketal bond, and encapsulating a near-infrared two-region fluorescent dye through hydrophobic interaction and self-assembling. The introduction of polyethylene glycol effectively improves the water solubility and biocompatibility of the liver protection drug silibinin, and at the same time, a drug-induced liver injury microenvironment can generate a large amount of active oxygen, the nano drug delivery system responsively degrades at an injury part, recovers quenched near-infrared two-region fluorescence, releases silibinin to exert anti-inflammatory and anti-oxidation curative effects, and has a good application prospect. The damaged liver is effectively identified, the problems of low drug loading rate, premature release, blood circulation leakage and the like in a physically coated nano drug delivery system are solved, and the specific diagnosis and treatment of the drug-induced liver injury are realized. The preparation method is simple and easy to implement and obvious in effect.

The invention discloses a silybin meglumine oral liquid and a preparation method thereof. The method comprises the following steps: preparing silybin meglumine powder, a sweetening agent, an acidulant and purified water as raw materials; under the conditions that the stirring speed is 250 rpm and the water temperature is 25-30 DEG C, silybin meglumine powder is slowly scattered into the purified water to be stirred for 45 minutes until the silybin meglumine powder is completely dissolved; adding a sweetening agent and an acidulant, continuously stirring for 10 minutes, and then filtering through a 0.22 mu m microfiltration membrane to obtain a sterile and transparent solution; and subpackaging the solution into sterile oral liquid bottles, and sealing and packaging. The silybin meglumine oral liquid prepared by the method has the advantages of high dissolution efficiency, optimized taste, sterility, safety, stable quality and the like, is suitable for industrial large-scale production, and can remarkably improve the medication compliance of patients. The method is simple in process, easy to operate and low in cost, and has wide popularization and application values.

The invention belongs to the technical field of biology, and discloses application of DVM nanoparticles in preparation of products for treating and / or preventing alcoholic liver diseases, the DVM nanoparticles contain gallic acid derivatives VM and dihydromyricetin; the mass ratio of the gallic acid derivative VM to the dihydromyricetin is 1: 3; in alcohol-induced HepG2 cells, the DVM nanoparticles can better reduce apoptosis of hepatocytes and generation of ROS, improve ADH activity, reduce AST and ALT activities in the cells and improve the hangover alleviating ability in mice, and have a more excellent liver protection effect compared with gallic acid and a positive drug silibinin.

The invention discloses a medicinal and edible composition which is characterized by comprising the following components in parts by weight: 15-20 parts of a hovenia dulcis thunb extract, 10-15 parts of a turmeric extract, 8-12 parts of a schisandra chinensis extract, 5-8 parts of a globe artichoke extract, 6-10 parts of a ganoderma lucidum spore powder extract and 0.5-1 part of a silibinin extract. According to the composite composition prepared by the invention, ethanol metabolism key enzyme (ADH / ALDH) is activated by multiple targets, acetaldehyde removal is accelerated, and a hepatocyte repairing function is supplemented, so that alcohol metabolism after drinking is accelerated, and damage of alcohol to a human body is reduced.

The utility model relates to the field of silibinin production, and discloses a silibinin granulator with a dustproof mechanism, which comprises a vertical frame and a lifting motor, and the dustproof mechanism is mounted in the vertical frame. According to the silybin granulator with the dustproof mechanism, the case, the lifting motor, the threaded column, the threaded sleeve, the movable plate, the pressing plate and the top cover are arranged, before the granulator works, the lifting motor is started at the position of the control case according to the height of a material receiving container, the lifting motor drives the threaded column to rotate, and therefore the threaded sleeve and the movable plate are driven to descend; the whole outer barrel descends until the pressing plate is pressed into the top of the material receiving container without a gap, at the moment, the discharging opening is sealed in the material receiving container, and the upper portion of the top of the outer barrel is sealed through the top cover, so that the silybin raw materials cannot be scattered from the upper portion or the lower portion, the device is suitable for the material receiving containers of various sizes, personnel are prevented from inhaling silybin powder, raw material waste is reduced, and the production cost is reduced. The workload of later cleaning is reduced, and the problem that raw material dust is scattered is solved.

The invention provides a compound peptide beverage capable of dispelling effects of alcohol and protecting liver as well as a preparation method and application thereof. The compound peptide beverage is prepared from hovenia dulcis thunb oligopeptide, walnut peptide, antioxidant peptide, energy release auxiliary peptide, ethanol dehydrogenase activating peptide, silibinin-serine chelate, an electrolyte poising agent, alginic acid oligosaccharide and purified water. Wherein the antioxidant peptide is prepared from cordyceps militaris, sea-buckthorn and sunflower disc through mixed enzymolysis, the energy release auxiliary peptide is prepared from carnosine and arginine succinic acid peptide through microbial fermentation, and the ethanol dehydrogenase activating peptide is prepared from marine shellfish collagen through fermentation. The composite peptide beverage shows excellent functions of dispelling the effects of alcohol and protecting the liver, and can be used for developing medicinal products or functional foods for dispelling the effects of alcohol and protecting the liver. Through precise compatibility and an innovative process technology, the product constructs a unique solution for dispelling the effects of alcohol and protecting the liver, and has outstanding performance in the aspects of improving the alcohol metabolism efficiency and relieving liver injury.

The application discloses a plant extraction compound for reducing blood pressure, a preparation method and application thereof. The compound is composed of high-purity silybin extract and a specific fusion polypeptide through molecular self-assembly. The sequence of the fusion polypeptide is shown in sequence SEQ ID NO:1, which innovatively integrates cell membrane penetration function, angiotensin II receptor 1 antagonism function and hydrophobic drug binding function. The core of the application is that through polypeptide-mediated active targeting, silybin is accurately delivered to the diseased blood vessel area, and the double synergistic mechanism of upstream ACE inhibition and downstream receptor blocking of the renin-angiotensin-aldosterone system is realized. In-vivo pharmacodynamic experiments prove that compared with single components, the compound can produce more significant and persistent antihypertensive effect, and can effectively reverse myocardial hypertrophy and fibrosis caused by hypertension, and show excellent synergistic therapeutic effect and target organ protection ability.

The application discloses a capsule for assisting in protecting chemical liver injury and a preparation method thereof, and belongs to the technical field of health-care food. The capsule is composed of curcuma longa extract 100g, silybum marianum extract 70g, schisandra chinensis extract 60g, microcrystalline cellulose 109.5g, silicon dioxide 7g and magnesium stearate 3.5g, and 1000 capsules are taken as a unit. The curcuma longa extract contains curcumin, the content of which is greater than or equal to 10% (10:1), the silybum marianum extract contains silybin, the content of which is greater than or equal to 20% (25:1), and the schisandra chinensis extract contains schisandrin, the content of which is greater than or equal to 1.5% (12.5:1). The three kinds of plant extracts are scientifically compounded, and the effects of antioxidation, anti-inflammation, liver cell membrane protection and bile secretion regulation are synergistically exerted. Through systematic screening of the types and dosages of the filling agent, the flow agent and the lubricant, the technical problems of poor flowability of the mixed plant extract powder, large filling difference and easy jamming are solved.

The invention discloses a preparation method of a silybin nanostructure lipid carrier, which comprises the following steps: step 1, heating ethanol and silybin in a water bath, and uniformly stirring to obtain a silybin solution; dispersing a co-emulsifier in deionized water, and heating and stirring in a water bath to obtain a water phase; step 2, adding solid lipid, liquid lipid, a main emulsifier and a co-emulsifier into the silibinin solution, heating for melting, and uniformly stirring to obtain an oil phase; under the condition of constant-temperature stirring, transferring the oil phase into the water phase, mixing the solution, and shearing to obtain a coarse dispersion system; and 3, heating the coarse dispersion system to concentrate the coarse dispersion system into an emulsion. The silibinin nanostructure lipid carrier prepared by the invention can improve the solubility of silibinin, and is good in characterization performance; the preparation cost is controllable, and macro preparation can be realized; the silybin nano-structure lipid carrier can be used for effectively preventing acute liver injury caused by CCl4 of animals.

The invention relates to a silibinin derivative as well as a preparation method and application thereof, and belongs to the technical field of chemistry. The invention relates to a silibinin derivative, which is 6-sulfonated silibinin sodium sulfonate, the chemical name of the silibinin derivative is 2, 3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-6-(3, 5, 7-trihydroxy-4-oxo benzopyran-2-yl) benzodioxane-6-sodium sulfonate, the molecular formula of the silibinin derivative is C25H21NaO13S, and the molecular weight of the silibinin derivative is 584.49. Sulfonic acid groups with hydrophilicity are introduced into different parts of the silibinin to prepare different types of silibinin sodium sulfonate, so that the solubility of the silibinin sodium sulfonate in water is enhanced, the pharmacokinetic characteristics of the silibinin are improved from the pharmacokinetic level, the affinity and biological activity of the silibinin to organisms are improved, and the application prospect of the silibinin sodium sulfonate is widened. The compound is further prepared into an injection for clinical treatment, and has important clinical drug treatment value.

The invention discloses a silybin C-5 site chemical modifier with anti-tumor activity and a preparation method thereof, and relates to an anti-tumor activity modifier prepared by modifying the structure of a natural product and a preparation method of the anti-tumor activity modifier. Silybin is used as a lead compound, firstly, silybin is dehydrogenated and oxidized into 2, 3-dehydrogenated silybin, and then the 2, 3-dehydrogenated silybin is added into the 2, 3-dehydrogenated silybin to prepare the silybin C-5 site chemical modifier with the anti-tumor activity. The method comprises the following steps: carrying out alkylation on silybin by using iodomethane on the basis of silybin to obtain 3, 5, 7, 20, 23-pentamethoxy-2, 3-dehydrosilybin, and further selectively demethylating a methoxy group at a C-5 site by using AlCl3 to obtain 5-hydroxy-3, 7, 20, 23-tetramethoxy-2, 3-dehydrosilybin, and further selectively demethylating a methoxy group at the C-5 site by using AlCl3 to obtain 5-hydroxy-3, 7, 20, 23-tetramethoxy-2, 3-dehydrosilybin. And finally, introducing different acyl groups on 5-OH to obtain the novel silybin derivatives I1-I19. Pharmacological experiment research shows that the compound has an obvious anti-proliferation effect on gastric cancer cells SGC-7901 and breast cancer cells MCF-7, and the anti-proliferation effect is better than that of silibinin. The structure of the silybin derivative is shown in the figure.

The invention relates to application of a pharmaceutical composition in preparation of a medicine for treating neurodegenerative diseases, and belongs to the technical field of medicines. The invention provides an application of a pharmaceutical composition in preparation of a medicine for preventing and / or treating neurodegenerative diseases, the active component of the pharmaceutical composition comprises silymarin, or the active component of the pharmaceutical composition comprises silybin, silymarin, silymarin and / or isosilybin, or the active component of the pharmaceutical composition comprises silybin, silymarin, silymarin and / or isosilybin. The silibinin comprises silibinin A and / or silibinin B; the isosilybin comprises isosilybin A and / or isosilybin B. The isosilybin is a mixture of isosilybin A and isosilybin B. Cell experiments prove that the pharmaceutical composition provided by the invention has quasi-nerve growth factor activity, so that the pharmaceutical composition provided by the invention, as a quasi-nerve growth factor active substance, has great application prospects in preparation of drugs for preventing and / or treating neurodegenerative diseases such as Alzheimer's disease and the like.

The invention relates to the technical field of medicine, in particular to a recombinant human XVII type collagen / silibinin nanoemulsion and a preparation method and application thereof, and the nanoemulsion is prepared from the following components in percentage by weight: 0.2%-1.5% of recombinant human XVII type collagen, 0.5% of silibinin, 1%-10% of lecithin, 1%-10% of glycerol, 3%-15% of Tween 80, 2%-8% of PEG400 and the balance of pure water. The prepared nano-emulsion is uniform in size and high in stability, irritation is effectively reduced, skin light damage can be remarkably repaired, the synergistic effect of oxidation resistance and barrier repair is achieved, UVB-induced oxidative stress, inflammatory response and skin structure damage are inhibited in multiple ways, and the nano-emulsion has a good prospect in application of skin UVB light damage repair.

The embodiment of the invention provides a composition for promoting desmogranulocytin expression, a skin care preparation and application. The composition and the skin care preparation can be used for promoting DSG1 expression. The composition for promoting the expression of desmogranulocytin comprises: silibinin; and a compound of formula (I); formula (I): # imgabs0 #

The invention discloses application of silibinin combined stem cells in treatment of rheumatoid arthritis, and relates to the technical field of biological medicines. The silybin is applied to the composition for treating the rheumatoid arthritis, the composition comprises umbilical cord-derived mesenchymal stem cells and the silybin, and the concentration of the silybin is 10-200 [mu] mol / L. The silybin and the umbilical cord-derived mesenchymal stem cells are combined for use, and the release of inflammatory factors can be remarkably inhibited by regulating the interaction of ICOS / ICOSL axes, so that the symptoms of rheumatoid arthritis are effectively relieved; due to the synergistic effect, the treatment effect is enhanced, and the limitation of a single treatment means is reduced; the silybin is used as a flavonoid compound extracted from traditional Chinese medicines, and has the characteristics of good safety and low side effect.

The invention discloses a health-care product composition for blood purification and liver and gall detoxification as well as a preparation method and application thereof, and belongs to the technical field of health-care products. The health-care product composition for blood purification and liver and gall detoxification provided by the invention is prepared from the following components in parts by mass: 10 to 40 parts of fermented barley leaf powder, 5 to 20 parts of a silibinin phospholipid complex, 5 to 15 parts of a dandelion extract, 5 to 15 parts of an artichoke extract, 5 to 10 parts of curcumin, 2 to 8 parts of alpha-lipoic acid and 1 to 5 parts of N-acetylcysteine. According to the composition, a four-dimensional synergistic purification system of intestinal adsorption purification, liver biochemical detoxification, bile excretion promotion and whole-course antioxidant protection is constructed, and the components are mutually promoted and enhanced at different time and space and different target spots to synergistically achieve the double effects of blood purification and liver and gallbladder detoxification.

The application provides a silibinin directional thin-layer molecular imprinting silica ball and a preparation method and application thereof, and belongs to the technical field of natural product separation and purification. The silibinin directional thin-layer molecular imprinting silica ball is prepared by constructing a directional recognition thin layer on the surface of silica microspheres through four steps of silanization, amidation, esterification and thin-layer polymerization. The silibinin directional thin-layer molecular imprinting silica ball can specifically recognize the meta-diol structure of silibinin by virtue of the electron-deficient boron atom of phenylboronic acid, and can form a stable covalent borate ester bond under weak alkaline conditions, and the bond can be reversibly broken under acidic conditions, so that the directional capture and mild elution of silibinin are realized. In combination with the precise site replication of the thin-layer imprinting, silibinin and other flavone impurities can be efficiently separated, the separation efficiency is improved by nearly 90% compared with traditional macroporous adsorption resin, and the purity of silibinin after separation can reach more than 95%.

The invention belongs to the technical field of pharmaceutical compositions, and particularly relates to a composition for improving the bioavailability of silibinin, a preparation method and application. Highly-dispersed micro-powder particles are formed by mixing the silybum marianum extract and the specific plant extracts (the liquorice extract, the radix puerariae extract and / or the gynostemma pentaphylla extract) according to a specific proportion and carrying out compressed air suspension, dispersion and granulation, and on the premise that an organic solvent and a surface active agent are not added, the micro-powder particles can be uniformly dispersed, so that the preparation process is simplified, and the preparation cost is reduced. According to the silybum marianum extract, the dissolution rate and bioavailability of silybin in the silybum marianum extract are remarkably improved, the label is clean, the preparation method is simple, and the silybum marianum extract has a good application prospect.

The invention discloses application of silibinin in preparation of a medicine for treating autoimmune hepatitis, and belongs to the field of biological medicine application. The silybin has a good liver protection effect, and a pathological experiment combined with a related mouse disease model in development of autoimmune liver injury pathogenesis research finds that the silybin can well relieve inflammation caused by the autoimmune liver injury, so that the silybin can replace or assist a traditional steroid hormone therapy, and the silybin has a good application prospect. And side effects caused by traditional therapy are reduced.