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Pharmaceutical composition with liver-protecting effect and preparation method thereof

A composition and drug technology, applied in the fields of medicine and food, can solve the problem of weak ability to inhibit fat oxidation, achieve strong inhibition of fat oxidation, prevent and treat chemical liver damage, and prevent and treat liver damage

Active Publication Date: 2014-03-26
JIANGSU DEHE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The limitation of single use of black tea polyphenols lies in their weak ability to inhibit fat oxidation

Method used

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  • Pharmaceutical composition with liver-protecting effect and preparation method thereof
  • Pharmaceutical composition with liver-protecting effect and preparation method thereof
  • Pharmaceutical composition with liver-protecting effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: Yigan Capsules

[0031] 1. Composition:

[0032] Black tea polyphenols 100kg, milk thistle extract 40kg.

[0033] 2. Preparation method:

[0034] (1) Preparation of black tea polyphenols: take black tea, soak and extract it with 10 times pure water according to the weight ratio, control the temperature at 80°C, filter out the tea after 30 minutes, then add pure water to soak once in the same method, and filter out the tea , combined the filtrate, concentrated to a solid content of 1%, extracted with 1.2 times the volume of ethyl acetate, concentrated the extracted ethyl acetate to a solid content of 5%, and used 0.1 times the volume of acidic water (pH value controlled at 3) Carry out reverse-phase water washing to remove impurities, backwash 5 times in the same method, take the ethyl acetate phase, concentrate and recover ethyl acetate, add a small amount of water to dissolve (control concentration 40%), spray dry, and obtain theaflavin-enriched Black ...

Embodiment 2

[0039] Embodiment 2: Yigan Granules

[0040] 1. Composition:

[0041] Black tea polyphenols 110kg, milk thistle extract 30kg.

[0042] 2. Preparation method:

[0043] (1) Preparation of black tea polyphenols: take black tea, soak and extract it with 8 times pure water according to the weight ratio, control the temperature at 90°C, filter out the tea after 20 minutes, then add pure water to soak once in the same method, and filter out the tea , combined the filtrate, concentrated to a solid content rate of 1%, extracted with 1.2 times the volume of ethyl acetate, concentrated the extracted ethyl acetate to a solid content rate of 5%, and used 0.1 times the volume of acidic water (PH value controlled at 2.5) Carry out reverse-phase water washing to remove impurities, backwash 6 times in the same method, take the ethyl acetate phase, concentrate and recover ethyl acetate, add a small amount of water to dissolve (control concentration 30%), spray dry, and obtain enriched theaf...

Embodiment 3

[0048] Embodiment 3: Yigan tablet

[0049] 1. Composition:

[0050] Black tea polyphenols 250kg, milk thistle extract 60kg.

[0051] 2. Preparation method:

[0052] (1) Preparation of black tea polyphenols: Take black tea, soak and extract it with 8 times pure water according to the weight ratio, control the temperature at 80°C, filter out the tea after 30 minutes, then add pure water to soak twice in the same method, and filter out the tea , combined the filtrate, concentrated to a solid content rate of 1.5%, extracted with 1.5 times the volume of ethyl acetate, concentrated the extracted ethyl acetate to a solid content rate of 8%, and used 0.2 times the volume of acidic water (the pH value was controlled at 3) Perform reverse-phase water washing to remove impurities, backwash 4 times in the same method, take the ethyl acetate phase, concentrate and recover ethyl acetate, add a small amount of water to dissolve (control concentration 50%), and spray dry to obtain theaflavi...

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Abstract

The invention relates to a pharmaceutical composition with liver-protecting effects. The composition comprises the following substances by weight: 6-15 parts of black tea polyphenol and 2-6 parts of a Silybum marianum extract. The silymarin and black tea polyphenol with different drug effects have very clear roles in prevention and treatment of chemical liver injury from different targets and the ways of, and are complementary with each other to effectively prevent and treat chemical liver injury. The two medicines are combined to perform the efficacies of strengthening and nourishing the liver, coursing the liver, detoxifying and immunoloregulation. Tests have proved that the pharmaceutical composition provided by the invention can prevent liver injury.

Description

technical field [0001] The invention relates to a pharmaceutical composition with hepatoprotective effect and a preparation method thereof. It belongs to the field of medicine and food. Background technique [0002] The liver is the largest gland in the human body. It plays a very important role in human metabolism, bile production, detoxification, blood coagulation, immunity, heat production, and regulation of water and electrolytes. Generally speaking, there are two main pathogenic factors that cause liver damage. One is liver inflammation caused by pathogenic microorganisms such as virus infection, such as hepatitis A and hepatitis B. The other type is chemical liver damage, which is liver damage caused by chemical hepatotoxic substances. As an important detoxification organ of the human body, the liver has dual blood supply from the hepatic artery and the hepatic vein. Chemicals can enter the liver through the portal vein of the gastrointestinal tract or the systemic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/82A61P1/16
Inventor 刘剑宏任雪音潘敏雄李士明曹后建
Owner JIANGSU DEHE BIOTECH
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