409 results about "Drug effect" patented technology

The invention discloses a sewage denitrification dosing method and system based on machine learning and a storage medium, and belongs to the technical field of sewage treatment.The method includes the steps that data are collected and preprocessed, and variable data influencing biochemical pool carbon source dosing behaviors are obtained; and lagging influence of carbon source input on the denitrification amount index is analyzed, and the duration time range of the drug effect is determined. And adopting the trained prediction model, and based on the denitrification amount index and the prediction variable of the future t + X period, obtaining the dosage of the (t + 1) th period. Through a correlation analysis method, the correlation rule of nitrogen conversion in the future X period after the carbon source is added is analyzed, the duration time of the drug effect is determined, the lag effect is accurately quantified, and the problem of mismatching of regulation and control opportunities is avoided. The hysteresis effect is captured and subjected to multi-factor coupling analysis based on the prediction model, the carbon source adding amount and time are optimized, system load fluctuation caused by excessive carbon sources or incomplete nitrogen removal caused by insufficient carbon sources are avoided, and the stability of an original sewage ecological system is gradually improved.

The invention relates to a painless gastrointestinal endoscope self-adaptive drug delivery method and system based on multi-source physiological signal fusion, and belongs to the technical field of medical artificial intelligence and automatic control. An artificial intelligence model is utilized to deeply extract features and quantitatively evaluate the sedation-analgesia level of a patient, a pharmacokinetics-pharmacodynamics model constructed by a big data platform is utilized to dynamically predict the drug effect according to the individual features and real-time state of the patient, and the anesthetic infusion rate is automatically and accurately adjusted through a closed-loop control algorithm, so that the patient can be accurately infused. Personalization and self-adaption of drug delivery are achieved, an independent safety monitoring mechanism is set, and real-time intervention is conducted on risk events such as respiratory depression. The problems that traditional anesthesia depends on artificial experience, single parameter monitoring is not comprehensive and individualized dynamic adjustment is lacked can be effectively solved, and the safety, comfort and medical efficiency of painless gastrointestinal endoscopy are remarkably improved.

The invention relates to the technical field of intelligent anesthesia precise regulation and control, and discloses an anesthetic dosage optimization method based on artificial intelligence. According to the method, a dynamic treatment interval is constructed, and the boundary of the dynamic treatment interval is adaptively adjusted according to the real-time sedation depth and the nociceptive stimulation level. And in the interval, performing pattern recognition on the continuous electroencephalogram signals and the hemodynamic parameters, and marking abnormal events deviating from a standard anesthesia state. And establishing a correlation network of the drug effect chamber concentration and the abnormal events, and generating a virtual drug response curve for predicting the trend of the abnormal events under different doses. Whether dose strategy reconstruction is started or not is determined by comparing the goodness of fit between the prediction curve and the actual physiological trajectory. During reconstruction, contribution weights of historical drug infusion points to abnormal events are backtracked and analyzed, and adjustment coefficients are distributed and integrated into a new infusion sequence. According to the invention, individualization and self-adaptive optimization of anesthesia administration are realized, and the accuracy and safety of anesthesia depth control are improved.

The invention provides a dynamic medication dosage optimization method fused with reinforcement learning. The method comprises the following steps: acquiring a first physiological index parameter of a target patient; obtaining a first diagnosis report of the target patient, wherein the first diagnosis report comprises basic information of the target patient and first disease information of the target patient; the first disease information comprises a first disease type and first disease description information; determining a first reinforcement learning algorithm corresponding to the first disease type; determining a first control parameter of the first reinforcement learning algorithm according to the first physiological index parameter and the basic information; and performing operation on the first disease description information through the first reinforcement learning algorithm and the first control parameter to obtain a first medication dosage parameter. Based on the application, the drug effect can be consistent with the physical condition of a patient, and poor drug effect and excessive side effects caused by too strong drug effect are avoided.

The invention discloses a medicinal and edible composition relaxing cream and a preparation method thereof. Comprising the following raw materials in parts by weight: 8-12 parts of kelp, 10-15 parts of oysters, 6-10 parts of fingered citron, 5-8 parts of dandelions, 5-8 parts of peach kernels, 10-15 parts of malt, 3-6 parts of brassica juncea, 10-15 parts of poria cocos, 5-8 parts of platycodon grandiflorum, 5-8 parts of fructus gardeniae, 8-12 parts of pericarpium citri reticulatae, 3-6 parts of rhizoma zingiberis, 10-15 parts of mulberries, 10-15 parts of rhizoma polygonati, 8-12 parts of codonopsis pilosula, 10-15 parts of hawthorn fruits, 3-6 parts of cinnamon, 5-8 parts of angelica sinensis and 3-6 parts of radix angelicae. The traditional Chinese medicine composition disclosed by the invention has the advantage of good use effect, and solves the problems that in the use process of the existing composition-relaxing cream, the multi-target synergistic effect is lacked, the curative effect is limited, heat-sensitive components are easy to degrade after long-time high-temperature boiling, and the drug effect exertion is influenced.

The invention provides a compound nystatin ointment and a preparation method thereof, and relates to the technical field of medicine preparation, the compound nystatin ointment comprises active ingredients of nystatin, neomycin sulfate, triamcinolone acetonide and permethrin, and the formula comprises liquid paraffin, white vaseline, wool fat, hexadecanol, PEG-30 dipolyhydroxystearate and glyceryl monoisostearate. According to the compound nystatin ointment preparation prescription process disclosed by the invention, the phenomenon of ointment matrix layering in the use process of commercially available products is mainly solved. According to a pharmaceutical research test, the stability of the compound nystatin ointment is superior to that of a commercially available original development agent, the ointment body character and the stability of active ingredients can be kept under the conditions of high temperature, high humidity, low temperature, freeze thawing and illumination, the maximum single impurity content and the total impurity content in the product are not obviously increased, and the quality is controllable. And meanwhile, an in-vitro transdermal test (IVPT) accidentally finds that the retention amount of related active ingredients is higher than that of the original development agent, and the drug effect is obviously improved. Through clinical test research, the compound nystatin ointment disclosed by the invention can be used for effectively treating external otitis caused by bacteria sensitive to neomycin, fungi sensitive to nystatin and ear mites sensitive to permethrin of dogs and cats.

The invention provides a betahistine hydrochloride pharmaceutical preparation and a preparation method thereof. The betahistine hydrochloride pharmaceutical preparation comprises conjugated linoleic acid, betahistine hydrochloride and auxiliary materials. Conjugated linoleic acid and betahistine hydrochloride are combined together for the first time, and conjugated double bonds of conjugated linoleic acid can be specifically combined with nitrite to block the generation of nitrosamine, so that the content of N-nitrosobetahistine can be remarkably reduced. Based on the chemical characteristics of conjugated linoleic acid, conjugated linoleic acid is used as a functional additive, targeted removal of nitrosamine impurities is achieved, and meanwhile the situation that exogenous toxic substances are introduced to affect the drug effect of betahistine hydrochloride is avoided. In the experiment process, it is also accidentally found that after the conjugated linoleic acid is added, the positive effect on cerebrovascular diseases is also achieved.

The invention discloses bee venom-containing skin essence with small irritation and a preparation method of the bee venom-containing skin essence. The skin essence is prepared from PLGA-PEG / liposome nanoparticles, a temperature-sensitive gel matrix, a protective agent, an antioxidant, a stabilizer and ultrapure water, the preparation method comprises the following steps: preparing the PLGA-PEG / liposome nanoparticles, preparing a poloxamer 407 solution, resuspending the nanoparticles, filling and storing. According to the invention, the melittin and the snake venom-like peptide have a synergistic effect on skin wrinkle resistance, so that the skin care effect is improved; pLGA-PEG / liposome nanoparticles are matched with a poloxamer solution to construct a dual sustained-release drug system, so that the irritation of drugs to skin is reduced, the lasting effect of the drug effect is improved, and the obtained skin essence has excellent moisturizing, whitening, anti-wrinkle and antioxidant capacities and is small in irritation.

The invention discloses a detection method for rapid real-time drug effect evaluation and application of the detection method. The detection method comprises the following steps: providing a quantitative corresponding relation between a same-generation calibration change value of electrical characteristics caused by physiological changes such as cell same-representative characteristics and the like and the cell proliferation ability; adhering to-be-detected cells to the surface of the same membrane electrode; applying the medicine to be detected, and observing the same generation measurement change value of the electrical characteristics in a cell proliferation cycle; and based on the quantitative corresponding relationship, obtaining the drug effect of the corresponding real-time proliferation characteristic evaluation drug. According to the detection method provided by the invention, the physiological changes such as the same-representative characteristics of the adherent cells are monitored through the membrane electrode, and after the quantitative corresponding relation between the change indexes of the same-representative characteristics of the cells and the proliferation capacity of the cells is established, the cell proliferation capacity is detected; the change of the cell proliferation capacity can be predicted through physiological changes such as the same representative characteristics of the cells before proliferation and apoptosis of the cells, so that the judgment period of the influence of the medicine on the cells can be greatly shortened, and the progress of medicine evaluation and research and development can be remarkably accelerated.

The invention provides a diketone biphenyl compound serving as a VAV1 degradation agent and application of the diketone biphenyl compound. Specifically provided are a compound represented by formula (I), a tautomer, a stereoisomer, a pharmaceutically acceptable salt or a prodrug thereof. The compound provided by the invention is good in drug effect and can be used for preparing drugs for treating or preventing VAV1 related diseases.

The invention discloses guanfacine hydrochloride sustained-release pellets and a preparation method thereof, and belongs to the technical field of biological medicines. The guanfacine hydrochloride sustained-release pellet comprises a drug-containing pellet core and a sustained-release layer, wherein the sustained-release layer is coated on the outer surface of the drug-containing pellet core; the medicine-containing pill core comprises the following components: guanfacine hydrochloride, a filling agent, a sustained-release material and a lubricating agent; and the sustained-release layer comprises the following components: a retardant, a plasticizer and an anti-sticking agent. The preparation method comprises the following steps: firstly, preparing guanfacine hydrochloride and auxiliary materials into a drug-containing pill core through an extrusion-rolling process, wherein the drug-containing pill core contains part of a sustained-release material for preventing sudden release of a drug; and then coating a sustained-release layer outside the drug-containing pellet core through fluidized bed coating to prepare the guanfacine hydrochloride sustained-release pellet. The guanfacine hydrochloride sustained-release pellet is free of burst release after being taken, is not influenced by individual differences of human bodies and pH of intestinal tracts, can tolerate peristalsis and extrusion of gastrointestinal tracts, is continuously released within 24 hours, keeps a proper concentration level in in-vivo blood, and is beneficial to reducing adverse reactions and continuously exerting drug effects.

The invention relates to the field of medicinal emulsifiable paste, in particular to compound fluconazole emulsifiable paste and a preparation method thereof. The compound fluconazole emulsifiable paste is prepared from the following components in parts by weight: 0.6 to 5 parts of fluconazole, 0.2 to 2 parts of neomycin sulfate, 0.1 to 0.2 part of triamcinolone acetonide, 5 to 15 parts of stearic acid, 10 to 25 parts of white vaseline, 2 to 8 parts of glyceryl monostearate, 0.5 to 3 parts of medicinal dimeticone, 1 to 5 parts of polysorbate-80, 0.1 to 0.3 part of sorbic acid, 0.1 to 1 part of vitamin E, 0.01 to 0.1 part of EDTA (Ethylene Diamine Tetraacetic Acid) disodium, 5 to 15 parts of glycerol and the balance of purified water, wherein the total amount is 100 parts. According to the application, the antioxidant property of the cream is improved by adding the vitamin E and the EDTA disodium, the vitamin E is used for directly scavenging free radicals, the EDTA disodium is used for eliminating an oxidation catalyst, and the quality guarantee period of the cream can be remarkably prolonged and the drug effect can be maintained by combining the vitamin E and the EDTA disodium.

The invention discloses a clinical medical care dispensing and sterilizing device in the technical field of medical care auxiliary equipment, which comprises a sterilizing box, the outer wall of the sterilizing box is fixedly connected with a display controller, the sterilizing box is internally and fixedly connected with a sterilizing assembly and a residue cleaning assembly, and the sterilizing assembly and the residue cleaning assembly are both in signal connection with the display controller. The device is used for solving the problems that traditional manual disinfection and an existing automatic disinfection device have disinfection blind areas and are insufficient in residue treatment when facing dispensing appliances in complex shapes, multi-angle and all-around efficient disinfection of the dispensing appliances is achieved by means of a flexible and movable mechanical structure in a physical and chemical combined disinfection mode, and the dispensing appliances are disinfected more efficiently. And the disinfection blind area is obviously reduced. Meanwhile, the device is provided with a special component for removing disinfection residues, so that the cleanness and safety of the disinfected appliances are ensured, and potential hazards of disinfection by-products to the drug effect and the health of a patient are avoided.

The invention provides a traditional Chinese medicine preparation quality detection method and system based on multi-dimensional data analysis, and belongs to the technical field of traditional Chinese medicine preparation quality detection. The method comprises the following steps: acquiring mass spectrum data and nuclear magnetic resonance data of various active components in a preparation to generate a multi-dimensional chemical characteristic data set; synchronously collecting corresponding data of the medicinal raw materials, and constructing a process and environment association database; constructing a chemical and process coupling analysis model; and monitoring the production process in real time to obtain the dynamic chemical fingerprint spectrum. By constructing a full-component chemical map and associating the full-component chemical map with process and environmental parameters and combining clinical curative effect data to establish a drug effect and component response curved surface model, the limitation that only a few index components are concerned in traditional detection is broken through, so that a detection result can accurately reflect the multi-target and overall regulation characteristics of the traditional Chinese medicine preparation, and the detection accuracy is improved. The problem that the components are qualified but the curative effect is poor due to single detection dimension is avoided, and the relevance between quality detection and the clinical curative effect is remarkably improved.

The invention discloses a multi-mode physical sign restraint strap remote monitoring system, and relates to the technical field of medical monitoring, the system is composed of a plurality of functional modules, and the system comprises a data acquisition module for acquiring monitoring data of a patient in real time, the monitoring data comprising physical sign data and medication data of the patient; the time sequence association construction module is used for preprocessing the monitoring data to obtain an effective physical sign data subset, performing dynamic time warping on the effective physical sign data subset based on a DTW algorithm to obtain an optimal time sequence anastomosis path, performing parameter estimation on the optimal time sequence anastomosis path by utilizing a linear regression model, and constructing a time sequence association trend of medicine-physical sign response; the intelligent analysis module is used for marking key nodes based on the time sequence correlation trend of the drug-physical sign response and performing multi-dimensional evaluation on the drug effect to obtain a drug effect evaluation value; and the drug use decision module is used for respectively carrying out transverse comparison and longitudinal analysis based on the drug effect evaluation value.

The application relates to the technical field of cough-relieving medicines, and discloses a high-efficiency cough-relieving loquat particle composition which is composed of the following components in parts by weight: loquat leaf extract 30-40 parts; white front extract 10-15 parts; platycodon grandiflorum extract 6-10 parts; white mulberry bark extract 18-25 parts; stemona sessiliflora extract 7-10 parts; menthol 0.1-0.5 part; polyethylene glycol 2-5 parts; mannitol 8-12 parts; ethyl cellulose 3-6 parts; hydroxypropyl methyl cellulose 1-3 parts; phosphatidylcholine 1-3 parts; polysorbate 80 1-3 parts; cross-linked sodium carboxymethyl cellulose 4-6 parts; and sucrose 40-60 parts. The double dispersion system combining the immediate-release component and the sustained-release component is adopted, the solubility and the initial release speed of the traditional Chinese medicine extract are remarkably improved through the addition of polyethylene glycol and mannitol, and the technical effect that the drug effect appearing time is remarkably shortened is achieved. Compared with the technical scheme relying on only a single release mode in the prior art, the deficiency that the drug effect is slow and the symptoms of the patient cannot be timely relieved is solved.

The invention discloses antisense oligonucleotides for reducing XDH gene expression in a targeted manner and application of the antisense oligonucleotides, and belongs to the technical field of biological medicines. The antisense oligonucleotide mediates the degradation of the target mRNA through an RNase H (RNase H) dependent cleavage mechanism, and the mRNA expression of the XDH gene is horizontally knocked down after transcription; the antisense oligonucleotide molecule has a specific nucleic acid sequence, is combined with chemical modification design, can specifically bind XDH mRNA molecules in a targeting manner, promote XDH mRNA degradation and inhibit XDH protein synthesis, so that the expression level of XDH in cells is reduced, uric acid synthesis is reduced, the purpose of reducing uric acid is finally achieved, and cell experiments and animal model tests show that the antisense oligonucleotide molecule has a good application prospect. The antisense oligonucleotide molecule disclosed by the invention has a good uric acid reducing effect, and is long in drug effect duration and high in drug safety.

The invention provides a preparation method and application of graphene pain-relieving health-care paste, and the method comprises the following steps: mixing carrageenan with water to obtain a carrageenan solution, and carrying out ionization degradation on the carrageenan solution to obtain a carrageenan oligosaccharide solution; the preparation method comprises the following steps: stirring graphene oxide and a carrageenan oligosaccharide solution, cleaning to obtain a mixed solution, adding sodium alginate into the mixed solution to prepare a gel precursor, and adding an anhydrous calcium chloride solution and effective components into the gel precursor to obtain the pain-relieving gel, and drying the gel to obtain the health-care paste. The health-care ointment has the effects of promoting blood circulation, activating collaterals and inhibiting inflammation, and is suitable for various chronic pains such as rheumatic arthritis and lumbar muscle degeneration and acute pains such as traumatic injury and muscle strain; the composition is also suitable for auxiliary relieving of postoperative pain, and has safety and long-term effect. Due to the thermal conductivity of the graphene oxide in the health-care cream, local skin blood circulation can be accelerated, the permeation efficiency of the herbal extract is improved, and the medicine effect of the effective components is improved.

The invention discloses a traditional Chinese medicine liniment for treating rheumatoid arthritis and a preparation process thereof, the traditional Chinese medicine liniment is composed of a wind-dispelling and pain-relieving liquid medicine and auxiliary materials, the wind-dispelling and pain-relieving liquid medicine contains eight traditional Chinese medicines of thorny elaeagnus root, erythrina bark, kadsura longepedunculata root, waxberry root, ardisia crenata, rose mallow root, glabrous sarcandra herb and wikstroemia canescens root, and is prepared by ultrasonic extraction; the auxiliary materials comprise polyvinyl alcohol, a chitosan-acetic acid solution, glycerol, azone, methylparaben, vanillyl butyl ether and ethanol. The liniment is short in film forming time and good in stability, has excellent transdermal absorption performance and antioxidant activity, can remarkably relieve joint swelling of RA model mice, improve the pain threshold value, improve joint pathological injuries, achieve local precise long-acting administration, reduce side effects of the whole body and improve patient compliance, is suitable for clinical treatment of RA, and has a wide application prospect. The problems that an existing rheumatoid arthritis treatment medicine is large in side effect, and a traditional Chinese medicine preparation is short in efficacy duration and inconvenient to use are solved.

The invention relates to the technical field of medicines, and discloses an application of combination of bufalin and heme in preparation of a cancer treatment medicine. According to the invention, by means of an active metabonomics means, a key active metabolite-heme is locked through exogenous library screening and endogenous analysis, and the drug effect of bufalin is regulated by means of the active metabolite. Through verification, it is found that heme can cooperate with the synergistic drug effect in various cancer cell lines, and a new technical normal form based on an active metabolome for improving the drug effect of bufalin is provided. The pharmaceutical composition can improve the apoptosis induction ability of bufalin to different cancer cells, and provides powerful guiding significance for developing a novel treatment scheme in clinical medicine.

The invention relates to the technical field of medical care data processing, and discloses a medical care data processing method and system based on artificial intelligence, and the method comprises the steps: recording a medicine taking moment, a medicine effect starting moment and a medicine effect ending moment when a user takes medicines of each dose type; executing a work intensity evaluation strategy for each time period, monitoring the typewriting frequency of the user in each time period, and calculating the work intensity of each time period according to the time period score of the user; according to historical workdays, executing a drug effect intensity matching strategy, and calculating the corresponding work intensity of the drugs of each dose category under the optimal work completion degree; executing an intelligent medicine taking time period matching strategy, and calculating the optimal medicine taking time and dosage type based on the predicted working intensity of the next workday; and a night dose intelligent back-pushing module is executed, the dose type of the medicine taken before sleep in the next workday is calculated, the matching degree between the medicine use and the work performance is improved, and the work efficiency and the state stability are maintained to the maximum extent.

The invention provides application of an SNP (Single Nucleotide Polymorphism) marker of MIA2 in predicting the curative effect of an antithrombotic drug on thrombus, and belongs to the fields of molecular biology and cardiovascular medicine. According to the application disclosed by the invention, one or more of rs11845046 and rs10134365 of the MIA2 gene is found to be related to the prediction of the curative effect of dabigatran on thrombus for the first time. Gene polymorphism analysis and an ROC curve verify that the curative effect of an NVAF patient after the NVAF patient is treated by using the antithrombotic drug is related to the genotypes of rs11845046 and rs10134365 of the MIA2 gene in a patient sample, and when the genotype of the rs11845046 is GG or the genotype of the rs10134365 is CC, the drug effect of the subject taking the antithrombotic drug is good but the probability of bleeding events is increased.

The invention discloses a hypnotic traditional Chinese medicine pillow based on traditional Chinese medicine theory and ergonomics and a traditional Chinese medicine formula in the pillow, and particularly relates to the technical field of hypnotic traditional Chinese medicine pillows.The hypnotic traditional Chinese medicine pillow comprises a pillow inner body and detachable medicine bags, the detachable medicine bags are symmetrically arranged on the left side and the right side of the pillow inner body, and the detachable medicine bags are filled with traditional Chinese medicine mixtures; the traditional Chinese medicine mixture is prepared from the following raw materials in parts by weight: 1 part of rhizoma atractylodis, 1 part of rhizoma acori graminei, 0.5 part of radix angelicae, 1 part of wormwood, 1 part of rhizoma cyperi and 0.2 part of rhizoma kaempferiae. The components complement and cooperate in pharmacological action to jointly enhance the effects of tranquilizing and allaying excitement and improving sleep, the sleeping effect is improved in cooperation with a specific micronization treatment and low-temperature crushing process, and the traditional Chinese medicine sleeping effect is improved through deep integration of the traditional Chinese medicine sleeping theory, ergonomic design and a modern preparation process. The nerve soothing effect of traditional Chinese medicine and cervical vertebra comfortable supporting form a superimposed effect, and multi-dimensional upgrading from a single sleeping function to stable medicine effect, comfortable use and convenient maintenance is achieved.

The present invention discloses a method and system for assessing the distribution pattern of GnRH neurons based on an electrode array. The electrode array collects electrical signals from the GnRH neuron region under the effects of a first induction drug and a second induction drug, respectively. The excitation rate corresponding to the first induction drug is calculated based on the discharge rate under the effect of the first induction drug, and the excitation rate corresponding to the second induction drug is calculated based on the discharge rate under the effect of the second induction drug. The excitation rates are used to identify GnRH neurons and regions. The electrode array has M rows and N columns, with the length of the electrode wires decreasing toward the center column, where M is a positive integer and N is a positive integer or a positive even number. The present invention can accurately assess the distribution pattern of GnRH neurons.

The invention discloses a medicinal composition for strengthening body resistance and nourishing liver as well as a preparation method and application thereof. The preparation method of the composition comprises the following steps: weighing the 15 medicinal materials according to the formula amount, crushing the turtle shell, decocting for about half an hour, then adding the rest medicinal materials, decocting, filtering, and concentrating the water decoction to 1 / 3-1 / 5 of the water addition amount, thereby obtaining the traditional Chinese medicine composition. The healthy-energy-strengthening and liver-nourishing soup has the effects of inducing diuresis, nourishing the liver, relieving ascites due to cirrhosis and the like, can relieve the symptoms of patients suffering from cirrhosis due to deficiency of healthy energy, blood stasis and qi stagnation and water retention, and can be used for treating cirrhosis diseases. The prepared decoction is fast in oral administration absorption and fast in drug effect exertion. And the product has high safety and no adverse reaction.

The invention discloses infantile massage oil with the effects of strengthening the spleen and nourishing the stomach and a preparation method thereof. The infantile massage oil with the effects of strengthening the spleen and nourishing the stomach is prepared from the following raw materials in parts by weight: 8 to 12 parts of fructus evodiae, 8 to 12 parts of radix aucklandiae, 8 to 12 parts of fried malt, 8 to 12 parts of rhizoma atractylodis, 4 to 8 parts of fried semen raphani, 15 to 25 parts of fructus amomi and 3 to 7 parts of fried endothelium corneum gigeriae galli. According to the infantile massage oil with the spleen-tonifying and stomach-nourishing effects, the working principles that the skin permeability is high, the medicine can be absorbed percutaneously, the medicine metabolism is fast, retention is avoided, the medicine can easily pass through a blood brain barrier, and the medicine effect can enter meridians and collaterals are utilized; through a three-in-one scheme of'compound compatibility design-carrier synergism-low-sensitivity matrix optimization ', the effects of tonifying the spleen and nourishing the stomach are achieved, the effect is good, and the effect taking speed is high.

The invention discloses a substance basis and a detection method for the drug effect of liver-bean jelly, and belongs to the technical field of medicines. In-vitro chemical components of liver-bean jelly are combined to track blood entering components of liver-bean jelly and carry out attribution analysis; obtaining an action target spot of the liver-bean linging for intervening the WD hepatic fibrosis; screening metabolic markers for significant callback of liver-bean linging, and performing enrichment analysis to obtain a significant metabolic pathway; constructing a'small molecule metabolite-reaction-enzyme-target 'composite metabolic network by the action target and the significant callback metabolic marker, and screening a core action target, a core metabolic marker and a core metabolic pathway; a molecular docking technology is used for screening a liver-bean drug effect material basis, and a multi-dimensional network of the liver-bean drug effect material basis, a core action target, a core metabolic marker, a core metabolic pathway and WD liver fibrosis is visualized. The invention discloses a pharmacodynamic material basis and a metabolic regulation mechanism for treating WD hepatic fibrosis by using liver bean paste.

The invention discloses a preparation method and a quality control method of a traditional Chinese medicine composition for stroke and middle meridian syndromes caused by extravasated blood blocking collaterals, and relates to the field of traditional Chinese medicines. The preparation method comprises the following steps: extracting salvia miltiorrhiza by adopting a composite enzymolysis-two-phase low-temperature extraction method, extracting erigeron breviscapus by adopting citric acid-ethanol extraction, extracting ligusticum wallichii by adopting double-template molecular imprinting-stir-frying with bran, extracting kudzu vine root by adopting a microwave method, adding auxiliary materials including hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose and beta-cyclodextrin, drying by adopting a centrifugal spray dryer, and packaging by adopting a packaging machine. The Maillard reaction is regulated and controlled. The method has the advantages of efficient extraction, component optimization, preparation stabilization, drug effect enhancement, adverse reaction rate reduction, quality controllability and the like.

The invention relates to the technical field of preparation methods of root and leaf protecting products, and discloses a preparation method of a root and leaf protecting product for promoting yield increase. Preparation equipment comprises a supporting frame and a mixing box, the mixing box is fixedly erected at the top of the supporting frame, and a sealing box cover is arranged at the top of the mixing box; the rear side of the sealing box cover is rotationally connected with the top of the mixing box, a discharging box is fixed to the bottom of the mixing box, a servo air cylinder is arranged on the side edge of the supporting frame, a stirring pipe is rotationally connected into the mixing box, and an output rod of the servo air cylinder rotationally penetrates into the mixing box and is fixed to the stirring pipe. Through a temperature control structure composed of the inner heating pipe and the temperature sensor, in the preparation process, the solvent temperature is controlled in time, material fusion is facilitated, the problem that the pesticide effect is easily affected due to uneven mixing in the preparation process of an existing root and leaf protecting product for promoting yield increase is solved, and the effectiveness of the root and leaf protecting agent in the preparation process is guaranteed.

The invention discloses a novel equivalence device structure closing and single-step repairing method and system in medical diagnosis, drug discovery and physiological status modeling, belongs to the field of medical diagnosis analysis, biological information processing and model verification, and ensures the reliability and traceability of the process through structural equivalence device detection and receipt track recording. The method monitors sequential equivalents (ABBA rectangles for checking consistency of operational orders) and conservation equivalents (triangles for checking information conservation and energy balance) during operation to find anomalies in diagnostic inference chains, drug action pathways, or physiological closed loops (such as predictor deviations, energy conservation imbalances, or model inconsistencies). When a non-equivalence condition is detected, the system selects a unique repair adapter from a geometric layer, a frame layer and a field layer for correction according to a preset priority, and the deviation metric mu is strictly reduced by one (delta mu = 1) during each repair, and is gradually converged to an equivalence closed state.