129 results about "Skin wrinkle" patented technology

The invention provides a ginseng exosome anti-aging and anti-oxidation composition and a preparation method thereof, and relates to the field of nursing materials, the ginseng exosome anti-aging and anti-oxidation composition comprises Exo nano-vesicles, procyanidine and cationic liposome, the Exo nano-vesicles are derived from ginseng extracellular fluid, the procyanidine is derived from the cationic liposome, and the cationic liposome is derived from the procyanidine. The ginseng exosome anti-aging and anti-oxidation composition provided by the invention can effectively improve skin wrinkles, enhance skin elasticity, promote collagen synthesis, inhibit collagen degradation and inhibit elastin degradation through the combined action of the Exo nano-vesicles, Pro and cationic lipidosome; degradation of elastin can cause skin to lose resilience, formation of wrinkles is accelerated, and facial skin can be effectively improved and wrinkles can be reduced by promoting synthesis of collagen and inhibiting degradation of elastin.

It relates to Centella asiatica-derived exosomes, which is useful in the treatment and / or care of skin. In particular, Centella asiatica-derived exosomes is effective in enhancing skin whitening, reducing skin wrinkles, enhancing skin hydration, and improving skin antioxidant capacity.

The invention relates to the technical field of cosmetics, in particular to an efficient anti-aging composition and a skin care product containing the composition. The invention discloses an efficient anti-aging composition which is prepared from the following raw materials in parts by mass: 12-15 parts of oil-based concentrated active ingredients, 25-35 parts of base collagen liquid, 15-18 parts of Ectoine, 12-16 parts of TWEEN 20 and 22-25 parts of isosorbide dimethyl ether, and the oil-based concentrated active ingredients are prepared from safflower seed oil, an extract of flowers / leaves / stems of herba lysimachiae, an extract of radix astragali membranaci, ubiquinone and vitamin E; the base collagen liquid comprises XVII type collagen, VII type collagen and IV type collagen. Aiming at the problems that an existing skin care product cannot effectively reduce skin wrinkles, improve skin compactness, reduce skin sagging and prevent skin aging for a long time, the composition disclosed by the invention realizes long-term aging resistance from epidermis to dermis, effectively reduces wrinkles, improves compactness and improves skin sagging.

A wound cleaning device for emergency surgery comprises a cleaning box (1), and a splash-proof push-aside wound cleaning mechanism is arranged on the cleaning box (1); the splash-proof push-aside wound cleaning mechanism comprises an opening disc (15) rotationally arranged in the middle of the front end face of the cleaning box (1), and the front end face of the inner cavity wall of the cleaning box (1) is fixedly connected with a gear ring (19). By means of the splash-proof push-aside wound cleaning mechanism, the distance between the opening and closing block (17) and the upper limb can be adjusted according to the thickness of the upper limb of a patient, the gap is made to be as small as possible, and then the possibility that disinfectant splashes to the human body and the surrounding environment is reduced; and when the wound is shielded by skin wrinkles, the skin near the wound can be gently pushed aside, so that the wound is completely exposed, and the thoroughness of washing is further improved.

The invention discloses bee venom-containing skin essence with small irritation and a preparation method of the bee venom-containing skin essence. The skin essence is prepared from PLGA-PEG / liposome nanoparticles, a temperature-sensitive gel matrix, a protective agent, an antioxidant, a stabilizer and ultrapure water, the preparation method comprises the following steps: preparing the PLGA-PEG / liposome nanoparticles, preparing a poloxamer 407 solution, resuspending the nanoparticles, filling and storing. According to the invention, the melittin and the snake venom-like peptide have a synergistic effect on skin wrinkle resistance, so that the skin care effect is improved; pLGA-PEG / liposome nanoparticles are matched with a poloxamer solution to construct a dual sustained-release drug system, so that the irritation of drugs to skin is reduced, the lasting effect of the drug effect is improved, and the obtained skin essence has excellent moisturizing, whitening, anti-wrinkle and antioxidant capacities and is small in irritation.

To provide a composition for external use on the skin for reducing skin wrinkles containing polyvinyl alcohol, and more particularly, a composition excellent in reducing skin wrinkles by sustainably contracting the skin only by drying after application to the skin without a separate film, by containing a high molecular weight polyvinyl alcohol.SOLUTION: The composition according to the present disclosure can reduce skin wrinkles without side effects and at a lower cost compared to conventional wrinkle-improving treatments.SELECTED DRAWING: Figure 1

The invention discloses application of tea extracellular vesicles in preparation of a product for preventing and / or treating UVB-induced skin photoaging, and belongs to the technical field of application of the tea extracellular vesicles. The tea extracellular vesicles are derived from tea leaves and / or stem leaves and are prepared by a method of combining enzymolysis, multi-stage filtration and ultracentrifugation, and the particle size of the tea extracellular vesicles is mainly distributed in a range of 60-100nm. Experiments show that the tea extracellular vesicles can effectively reduce active oxygen accumulation and lipid peroxidation caused by UVB radiation, repair mitochondrial membrane potential and inhibit expression of matrix metalloproteinase and inflammatory factors, so that photoaging symptoms such as skin wrinkles, erythema and barrier function damage are relieved. The tea extracellular vesicle provided by the invention has the advantages of natural raw materials, good biocompatibility, small side effect and the like, can be used for preparing a plurality of external dosage forms such as gel, cream, spray and the like, and provides a safe and effective new natural product choice for prevention and treatment of skin photoaging.

The invention belongs to the technical field of mesenchymal stem cell exosome compositions, and discloses a preparation method and application of a mesenchymal stem cell exosome composition. The mesenchymal stem cell exosome composition is prepared from a mesenchymal stem cell exosome, a hyaluronic acid-arginine grafted copolymer, acetyl tetrapeptide-5, resveratrol, mannose, polyglycerol-8 octoate and a buffer solution. Arginine residues contained in the hyaluronic acid-arginine graft copolymer in the composition can be specifically combined with integrin receptors (such as alpha v beta 3) highly expressed by fibroblasts at the wrinkle part, so that the exosome can actively anchor the wrinkle part, can be accurately and directionally enriched at the wrinkle part, and is high in utilization rate and high in anti-wrinkle efficiency. The composition constructs a three-dimensional anti-wrinkle network of mesenchymal stem cell exosome, acetyl tetrapeptide-5 and resveratrol, skin collagen degradation and oxidative damage are effectively restrained, and generation of skin wrinkles is blocked through multiple channels.

The invention provides an anti-aging composition containing schizophyllan, a medical beauty injection preparation and application of the anti-aging composition and the medical beauty injection preparation, the anti-aging composition comprises hyaluronic acid or salt of the hyaluronic acid, the schizophyllan and mannitol, and the mass ratio of the hyaluronic acid or the salt of the hyaluronic acid to the schizophyllan to the mannitol is (0.2-3): (0.01-0.5): (0.5-5). According to the anti-aging composition disclosed by the invention, through the multi-component synergistic effect of the schizophyllatin, the hyaluronic acid or the salt thereof and the mannitol, the proliferation activity of fibroblasts can be remarkably improved, and the synthesis and expression of collagen can be efficiently promoted, so that the depth and the quantity of skin wrinkles are effectively improved, and the compactness and the elasticity of the skin are remarkably enhanced; the comprehensive skin rejuvenation effect is realized.

An anti-aging injection composition, an anti-aging injection, and use thereof. The anti-aging injection composition contains hyaluronic acid or a salt thereof, glycine, proline, lysine hydrochloride, and leucine, which can synergistically promote the generation of collagen and elastin in the skin, thereby helping to correct skin wrinkles, improve skin elasticity, and enhance skin radiance. The anti-aging injection composition can be used to prepare an anti-aging injection, which has the effect of resisting skin aging.

The present invention relates to a compound of formula (I) R1-Wm-Xn-AA1-AA2-AA3-AA4-Yo-Zp-R2, stereoisomers and / or cosmetically acceptable salts thereof, in which: AA1 is Leu, Ile or Val; aA2 is Pro, Ala or Gly; aA3 is Val, Ile or Leu; aA4 is Thr, Val or a non-amino acid. The compounds are useful for treating and / or preventing symptoms of skin aging, and in particular for treating and / or preventing skin wrinkles, improving or maintaining skin compactness, treating and / or preventing the appearance of skin sagging, and / or lifting skin.

The present invention relates to a composition comprising a mixture of exosomes derived from different cells, as an active ingredient and use thereof. More specifically, the present invention relates to a composition for treating skin diseases and / or improving skin conditions, comprising, as an active ingredient, mixed exosomes or fused exosomes in which natural killer cell-derived exosomes and mesenchymal stem cell-derived exosomes are mixed or fused. The composition according to the present invention exhibits an excellent cell proliferation effect and the effect of promoting collagen production, and thus can be effectively used as not only a cosmetic material for improving skin conditions, such as by reducing skin wrinkles, regenerating wounds, and increasing elasticity, but also a pharmaceutical material for preventing or treating skin diseases such as atopic dermatitis.

The invention relates to a tightening and lifting mask and a preparation method thereof. The mask liquid comprises the following functional components: saccharomycetes / rice fermentation product filtrate, palmitoyl tripeptide-5 and fibronectin, the mass ratio of the saccharomycetes / rice fermentation product filtrate to the palmitoyl tripeptide-5 to the fibronectin is (0.1-30): (0.01-6): (0.01-2). Compared with the prior art, through the synergistic effects of the saccharomycetes / rice fermentation product filtrate, palmitoyl tripeptide-5 and fibronectin on the aspects of enhancing the skin barrier function, promoting collagen generation, slowing down collagen decomposition, regulating adhesion, migration and proliferation of cells, removing reactive oxygen free radicals and the like, collagen generation of the corium layer is promoted, and the skin care effect is achieved. Skin wrinkles are reduced, and a long-term tightening and lifting effect is achieved.

The invention provides oral recombinant human elastin capable of repairing skin subacute aging injury and application of the oral recombinant human elastin, and belongs to the technical field of biotechnology and functional food. The oral recombinant human elastin capable of repairing skin subacute aging injury is prepared in a gene recombination expression mode. The recombinant human elastin has both a beta-spiral hydrophobic structure domain and a lysine-rich hydrophilic region, and shows excellent biological safety and biological activity; after the traditional Chinese medicine composition is prepared into an oral preparation, skin wrinkles can be remarkably reduced, the skin water content and dermis density can be improved, transdermal water loss can be reduced, the hydroxyproline level can be increased, collagen generation can be promoted, elasticity can be recovered, and skin oxidative stress reaction can be effectively inhibited. The method solves the problems that the natural elastin source is limited and the biological safety is insufficient, and has a wide industrialization prospect.

The present invention relates to a composition comprising plant extracts. The composition according to the present invention has a skin whitening effect by reducing the total amount of melanin and tyrosinase activity in melanocytes of the skin, promotes skin regeneration and increases skin elasticity or reduces skin wrinkles by promoting collagen synthesis and inhibiting collagenase activity in fibroblasts of the skin, has an anti-inflammatory effect or a skin soothing effect by inhibiting NO generation, increases the amount of moisture in the skin and has a moisturizing effect by promoting generation of hyaluronic acid in fibroblasts, and has an antioxidant effect by scavenging free radicals. In addition, since the composition of the present invention exhibits a broad antibacterial effect against various bacteria, the composition may be used as a cosmetic composition, a pharmaceutical composition, a skin external preparation, or a food composition.

This invention discloses a strain of Bifidobacterium animalis subspecies TRT-2A with allergy-relieving effects and its extracellular vesicle applications. The strain TRT-2A is deposited at the China Center for Type Culture Collection (CCTCC) on November 21, 2025, with accession number CCTCC NO:M 20252645. This strain is highly acid-resistant and exhibits good tolerance to artificial gastric and intestinal fluids. It effectively inhibits bacteria, particularly Streptococcus pyogenes, Streptococcus agalactiae, and / or Escherichia coli. Experimental results show that this strain can alleviate hormone-dependent dermatitis and effectively improve dermatitis symptoms such as erythema and desquamation. Furthermore, extracellular vesicles prepared using TRT-2A can effectively improve skin elasticity and reduce wrinkles. Therefore, the Bifidobacterium animalis subspecies TRT-2A of this invention has multiple functions and is worthy of further promotion and application.

The present invention relates to a cosmetic composition for skin elasticity enhancement, skin wrinkle alleviation, and skin whitening, comprising a fermented extract of Perilla frutescens var. acuta Kudo as an active ingredient. The cosmetic composition comprising a fermented extract of Perilla frutescens var. acuta Kudo as an active ingredient, according to one embodiment of the present invention, comprises components derived from natural products and thus is harmless to the human body and exhibits remarkable efficacy in increasing collagen production and ability to inhibit melanin production, thereby being useful for skin elasticity enhancement, skin wrinkle alleviation, and skin whitening.

The invention relates to the field of beauty, in particular to a beauty product and application thereof. In particular, the present invention relates to a cosmetic product comprising a concentrate and ultrasonically treated hyaluronic acid, the hyaluronic acid having an average molecular weight in the range of from 100 kD to 500 kDa; wherein the concentrate comprises at least one growth factor and at least one cytokine. The invention also relates to the use of said cosmetic product for promoting tissue regeneration, improving skin quality, reducing skin wrinkles and scars, and reducing skin irritation and flaws.

The present invention relates to a novel use of a mitochondria-derived peptide with high skin permeability and, more particularly, to a composition for reducing skin wrinkles or whitening skin comprising the peptide. The mitochondria-derived peptide according to the present invention not only exhibits high skin permeability but also excellent wrinkle reduction and whitening effects, and thus can be variously used in the cosmetic and food fields related to skin wrinkle reduction or skin whitening.

The utility model discloses an excrement and urine collecting bag, which particularly relates to the technical field of medical instruments and comprises a soft application, a bag body with two openings, a first one-way valve hole in butt joint with an injector and a second one-way valve hole in butt joint with a drainage tube. One opening of the bag body is fixedly connected with the soft application, the other opening of the bag body is fixedly provided with a sealing clip, the first one-way valve hole and the second one-way valve hole are both fixedly formed in the position, close to the soft application, of the bag body, and a drainage connector is fixedly installed at the position, close to the sealing clip, of the bag body; and a leakage-proof mechanism and a sticking mechanism are arranged on one side, far away from the bag body, of the soft application. The design that the base plate is replaced by the soft application is adopted, the soft application is made of soft materials, skin protection factors are sprayed in the soft application, and therefore the soft application has the advantages of being light, thin and skin-friendly, foreign body sensation can be reduced, and the skin can be protected; the butterfly-shaped application is adopted as the soft application, so that the soft application is better attached to the skin, and fixation is prevented from being affected by skin wrinkles or secretions.

The present application provides a kind of human umbilical cord mesenchymal stem cell secretory exosome and anti-aging essence based on the exosome and its preparation method and application.By activating Wnt / β-catenin signaling pathway, the yield of exosome and the secretion amount of miR-21 are significantly improved, and the purity and biological activity of exosome are effectively purified by using microfluidic technology. The essence formula contains exosome, HA-Lipo composite carrier, asiaticoside microspheres and dipropylene glycol, and has good skin repair and anti-aging effect. Animal experiments have verified that the essence of the present application can effectively improve skin wrinkles, epidermal thickness and skin barrier function in UVB-induced skin photoaging model, and its molecular mechanism is related to the regulation of collagen metabolism. The essence has significant application prospect in the field of skin beauty and anti-aging.

The present invention relates to a composition for improving skin function, containing Lactobacillus plantarum as an active ingredient and, specifically, to a composition having the effects of activating primary cilia, improving skin barrier function, soothing skin, reducing skin wrinkles, whitening skin, and inhibiting melanin production, the composition containing a Lactobacillus plantarum beLP1 strain, a lysate thereof, a culture thereof, a concentrate thereof, a dried product thereof, or dead cells thereof as an active ingredient.

To provide a memory film that has excellent mechanical properties and stretchability, maintains its stretched state when stretched and dried, and contracts the skin with a pre-memorized contractile force when attached to wet skin, the memory film having the effect of improving skin elasticity, improving skin wrinkles, and increasing skin density, as well as reducing pore depth, pore area, pore count, and pore volume.SOLUTION: In one aspect of the present invention, a memory film is provided that includes a first layer containing acrylic acid and polyurethane and that is attached to the skin and contracts at a memorized rate after a period of time. In another aspect of the present invention, a method for producing the memory film described above is provided, the method comprising the steps of: applying and drying a solution containing acrylic acid and polyurethane; and stretching the applied and dried material.SELECTED DRAWING: Figure 1

The invention belongs to the technical field of image segmentation, and discloses a lesion image processing system and method based on deep learning, and the method comprises the steps: obtaining a skin image, and extracting a multi-scale hierarchical feature map of the skin image through an encoder; inputting the multi-scale hierarchical feature map into a dual-path processing module, and outputting a first path output feature and a second path output feature; inputting the first path output feature and the second path output feature into a feature fusion module, and performing weighted fusion based on a cross attention mechanism to generate a fusion feature map; and inputting the fused feature map into a segmentation decoder, and outputting a segmented region map of the milk coffee spots after multi-scale context aggregation. According to the method, specific inhibition is performed on skin color variation and skin wrinkle interference, feature complementary fusion is realized in combination with a cross attention mechanism, and multi-scale context information is integrated in a segmentation decoder, so that the accuracy, robustness and generalization ability of a milk coffee spot segmentation task under a complex skin background can be remarkably improved.

One aspect of the present disclosure relates to a cosmetic composition comprising Hibiscus Manihot L. extract and a method for preparing the same, which has an effect of improving skin elasticity, alleviating skin wrinkles, etc.

The application relates to the cosmetic technical field, in particular to a high-efficiency anti-aging composition and a skin care product containing the same. The high-efficiency anti-aging composition is prepared from the following raw materials in parts by mass: 12-15 parts of oil-based concentrated active ingredients, 25-35 parts of base collagen liquid, 15-18 parts of ikar, 12-16 parts of TWEEN 20, and 22-25 parts of isosorbide dimethyl ether. The oil-based concentrated active ingredients include safflower seed oil, acmella oleracea flower / leaf / stem extract, Astragalus membranaceus (Fisch.) Bunge root extract, ubiquinone and vitamin E. The base collagen liquid includes type XVII collagen, type VII collagen and type IV collagen. The composition can effectively reduce skin wrinkles, improve skin tightness and reduce skin sagging in a long term, and prevent skin aging, and realizes long-term anti-aging from epidermis to dermis.

The utility model provides a composite material T-shaped stringer which comprises a left L-shaped layer plate, a right L-shaped layer plate and a bottom layer plate arranged at the bottom of the left L-shaped layer plate and the bottom of the right L-shaped layer plate, the left L-shaped layer plate and the right L-shaped layer plate are symmetrically arranged relative to the longitudinal center face of the composite material T-shaped stringer, and each of the left L-shaped layer plate and the right L-shaped layer plate comprises a plurality of prepreg laying layers. The left L-shaped laminate and the right L-shaped laminate are respectively provided with edge structures which are positioned at two ends of the composite T-shaped stringer along the width direction of the composite T-shaped stringer, and a plurality of prepreg paving layers in the edge structures are constructed to coat the bottom laminate layer by layer from inside to outside so as to form a wedge-shaped oblique angle structure of which the edges are coated layer by layer; and the tail parts of the plurality of prepreg paving layers in the edge structure are in contact with the bottom laminate. The wedge-shaped oblique angle structure wrapping the edge of the bottom of the T-shaped stringer layer by layer can effectively avoid the skin wrinkling problem of the stiffened wall plate prepared by adopting a dry stringer-wet skin co-bonding forming process, and can also avoid the risk of layering of the edge of the bottom of the stringer.

The invention provides an exosome secreted by human umbilical cord mesenchymal stem cells, an anti-aging essence based on the exosome, and a preparation method and application of the anti-aging essence. By activating a Wnt / beta-catenin signal channel, the yield of the exosome and the secretion amount of miR-21 are remarkably improved, and the exosome is effectively purified by utilizing a microfluidic technology, so that the purity and the biological activity of the exosome are improved. The formula of the essence comprises the exosome, the HA-Lipo composite carrier, asiaticoside microspheres and dipropylene glycol, and the essence has good skin repairing and anti-aging effects. Animal experiments verify that the essence can effectively improve skin wrinkles, epidermis thickness and skin barrier functions in a UVB-induced skin photoaging model, and the molecular mechanism of the essence relates to regulation and control of collagen metabolism. The essence has a remarkable application prospect in the fields of skin beautifying and anti-aging.

The present invention addresses the problem of using yeast-derived cell walls to provide a material which has a skin wrinkle improving effect and is further useful as a tactile sensation improver when applied to the skin. The present inventors have completed the present invention by finding that a cosmetic composition having a skin wrinkle improving effect, a moisture retaining effect, and a skin barrier effect can be provided by using a yeast cell wall-containing composition having a yeast cell wall structure, and also can be used as a tactile sensation improving agent through an in-depth study. Further, the composition comprising the yeast cell wall of the present invention can be extracted from a food yeast, and thus belongs to a food microorganism source and can be safely used.

A composition containing iris-derived exosomes as an active ingredient is provided for skin elasticity improvement, skin wrinkle reduction, skin regeneration, skin tone improvement, skin brightness improvement, skin whitening, anti-inflammation, wound healing and / or wound healing acceleration.