175 results about "Skin wrinkle" patented technology

The invention discloses a collagen composition for skin substrate repair and skin care application thereof, and the collagen composition comprises the following components: 1-3% of soluble III-type collagen, 1-5% of hyaluronic acid, 1-2% of plant extract, 0.1-0.5% of allantoin, 0.2-0.5% of dipotassium glycyrrhizinate, 1-5% of glycerol, 1-5% of butanediol, 1-5% of 1, 2-propylene glycol, 1-5% of 1, 3-propylene glycol, 1-5% of propylene glycol and the balance of water. The cleaning agent is prepared from the following components in percentage by weight: 1 to 2 percent of 1, 2-hexanediol, 0.1 to 0.5 percent of phenoxyethanol, 0.1 to 0.5 percent of ethylhexylglycerin, 0.1 to 0.5 percent of carbomer, 0.1 to 0.5 percent of triethanolamine and the balance of water. The collagen III is added, so that the problems of wrinkles and skin aging are remarkably relieved. According to the skin-care lotion, the oily composition and the water-based composition are reasonably proportioned, so that excellent moistening and moisturizing effects are provided, the moisture balance of the skin is favorably maintained, and the skin is kept soft and moist. The added plant extract, hydrolyzed protein and mineral substances not only nourish and repair the skin, but also can improve various skin problems, enhance the endurance capacity of the skin and avoid the condition that the skin wrinkles are increased during the period of stopping using.

The invention discloses a composition with tightening, wrinkle fading, soothing and repairing effects and application of the composition. The composition with the effects of tightening and fading wrinkles and relieving and repairing is prepared from a lactobacillus fermentation product, hexanediol, fully human collagen, glycosylglycerol, a citrus peel extract, a palmitoyl tripeptide-5 solution, a chrysanthemum extract and SPG beta-glucan. According to the invention, seven active material raw materials including the lactobacillus fermentation product, the fully human collagen, the glycosylglycerol, the citrus peel extract, the palmitoyl tripeptide-5 solution, the chrysanthemum extract and the SPG beta-glucan are creatively combined for use, and the seven raw materials supplement each other and have a synergistic effect; the effects of lightening skin wrinkles, improving skin barriers and relieving skin sensitivity are achieved from multiple dimensions, and cosmetics prepared from the composition have the effects of repairing, relieving, tightening and resisting wrinkles.

The invention provides a ginseng exosome anti-aging and anti-oxidation composition and a preparation method thereof, and relates to the field of nursing materials, the ginseng exosome anti-aging and anti-oxidation composition comprises Exo nano-vesicles, procyanidine and cationic liposome, the Exo nano-vesicles are derived from ginseng extracellular fluid, the procyanidine is derived from the cationic liposome, and the cationic liposome is derived from the procyanidine. The ginseng exosome anti-aging and anti-oxidation composition provided by the invention can effectively improve skin wrinkles, enhance skin elasticity, promote collagen synthesis, inhibit collagen degradation and inhibit elastin degradation through the combined action of the Exo nano-vesicles, Pro and cationic lipidosome; degradation of elastin can cause skin to lose resilience, formation of wrinkles is accelerated, and facial skin can be effectively improved and wrinkles can be reduced by promoting synthesis of collagen and inhibiting degradation of elastin.

It relates to Centella asiatica-derived exosomes, which is useful in the treatment and / or care of skin. In particular, Centella asiatica-derived exosomes is effective in enhancing skin whitening, reducing skin wrinkles, enhancing skin hydration, and improving skin antioxidant capacity.

The present disclosure relates to glycosaminoglycan-collagen copolymer compositions (such as hyaluronic acid-collagen copolymers and heparosan-collagen copolymer compositions) and medical applications thereof for augmenting soft tissue defects. The copolymer composition may be injected into tissues to correct defects or deficiencies, such as skin wrinkles, scars, and folds in dermal tissues.

The present application relates to the field of cosmetic technology, more specifically, it relates to an anti-aging composition, anti-aging cosmetics and anti-aging essence.An anti-aging composition is composed of hydroxypinacolone retinoic acid ester, Buddleja flos extract and oligopeptides, and the weight ratio of the hydroxypinacolone retinoic acid ester, Buddleja flos extract and oligopeptides is 1:(0.20-0.25):(6.5-7.0).The anti-aging composition of the present application, using hydroxypinacolone retinoic acid ester, Buddleja flos extract and oligopeptides to be compounded, can effectively resist ultraviolet light, has good antioxidant and hydrating properties, can be applied to prepare cosmetics, improve skin wrinkles.

The invention relates to the technical field of cosmetics, in particular to an efficient anti-aging composition and a skin care product containing the composition. The invention discloses an efficient anti-aging composition which is prepared from the following raw materials in parts by mass: 12-15 parts of oil-based concentrated active ingredients, 25-35 parts of base collagen liquid, 15-18 parts of Ectoine, 12-16 parts of TWEEN 20 and 22-25 parts of isosorbide dimethyl ether, and the oil-based concentrated active ingredients are prepared from safflower seed oil, an extract of flowers / leaves / stems of herba lysimachiae, an extract of radix astragali membranaci, ubiquinone and vitamin E; the base collagen liquid comprises XVII type collagen, VII type collagen and IV type collagen. Aiming at the problems that an existing skin care product cannot effectively reduce skin wrinkles, improve skin compactness, reduce skin sagging and prevent skin aging for a long time, the composition disclosed by the invention realizes long-term aging resistance from epidermis to dermis, effectively reduces wrinkles, improves compactness and improves skin sagging.

A wound cleaning device for emergency surgery comprises a cleaning box (1), and a splash-proof push-aside wound cleaning mechanism is arranged on the cleaning box (1); the splash-proof push-aside wound cleaning mechanism comprises an opening disc (15) rotationally arranged in the middle of the front end face of the cleaning box (1), and the front end face of the inner cavity wall of the cleaning box (1) is fixedly connected with a gear ring (19). By means of the splash-proof push-aside wound cleaning mechanism, the distance between the opening and closing block (17) and the upper limb can be adjusted according to the thickness of the upper limb of a patient, the gap is made to be as small as possible, and then the possibility that disinfectant splashes to the human body and the surrounding environment is reduced; and when the wound is shielded by skin wrinkles, the skin near the wound can be gently pushed aside, so that the wound is completely exposed, and the thoroughness of washing is further improved.

The invention discloses bee venom-containing skin essence with small irritation and a preparation method of the bee venom-containing skin essence. The skin essence is prepared from PLGA-PEG / liposome nanoparticles, a temperature-sensitive gel matrix, a protective agent, an antioxidant, a stabilizer and ultrapure water, the preparation method comprises the following steps: preparing the PLGA-PEG / liposome nanoparticles, preparing a poloxamer 407 solution, resuspending the nanoparticles, filling and storing. According to the invention, the melittin and the snake venom-like peptide have a synergistic effect on skin wrinkle resistance, so that the skin care effect is improved; pLGA-PEG / liposome nanoparticles are matched with a poloxamer solution to construct a dual sustained-release drug system, so that the irritation of drugs to skin is reduced, the lasting effect of the drug effect is improved, and the obtained skin essence has excellent moisturizing, whitening, anti-wrinkle and antioxidant capacities and is small in irritation.

To provide a composition for external use on the skin for reducing skin wrinkles containing polyvinyl alcohol, and more particularly, a composition excellent in reducing skin wrinkles by sustainably contracting the skin only by drying after application to the skin without a separate film, by containing a high molecular weight polyvinyl alcohol.SOLUTION: The composition according to the present disclosure can reduce skin wrinkles without side effects and at a lower cost compared to conventional wrinkle-improving treatments.SELECTED DRAWING: Figure 1

The invention discloses application of tea extracellular vesicles in preparation of a product for preventing and / or treating UVB-induced skin photoaging, and belongs to the technical field of application of the tea extracellular vesicles. The tea extracellular vesicles are derived from tea leaves and / or stem leaves and are prepared by a method of combining enzymolysis, multi-stage filtration and ultracentrifugation, and the particle size of the tea extracellular vesicles is mainly distributed in a range of 60-100nm. Experiments show that the tea extracellular vesicles can effectively reduce active oxygen accumulation and lipid peroxidation caused by UVB radiation, repair mitochondrial membrane potential and inhibit expression of matrix metalloproteinase and inflammatory factors, so that photoaging symptoms such as skin wrinkles, erythema and barrier function damage are relieved. The tea extracellular vesicle provided by the invention has the advantages of natural raw materials, good biocompatibility, small side effect and the like, can be used for preparing a plurality of external dosage forms such as gel, cream, spray and the like, and provides a safe and effective new natural product choice for prevention and treatment of skin photoaging.

The invention discloses an anti-aging composition for preventing light aging and application thereof, the anti-aging composition comprises a Rosa rugosa extract, a Caesalpinia spinosa fruit extract, a sunflower bud extract and a Pseudoalteromonas fermentation product extract, and the anti-aging composition can be added into various skin care products to reduce cell damage caused by light radiation such as ultraviolet light, infrared light and blue light; in sunscreen cosmetics, the sunscreen effect can be improved, the use amount of chemical sunscreen agents and physical sunscreen agents is reduced, and the safety and mildness of the sunscreen cosmetics are improved; damage caused by optical radiation is effectively prevented, meanwhile, skin elasticity is improved, skin wrinkles are reduced, and the effect of resisting skin photoaging is achieved. The effectiveness of the composition is proved through a large number of experiments, each component is irreplaceable, the addition range of the composition is also an optimal range, and the effect and cost of the composition are both the optimal range.

The invention belongs to the technical field of mesenchymal stem cell exosome compositions, and discloses a preparation method and application of a mesenchymal stem cell exosome composition. The mesenchymal stem cell exosome composition is prepared from a mesenchymal stem cell exosome, a hyaluronic acid-arginine grafted copolymer, acetyl tetrapeptide-5, resveratrol, mannose, polyglycerol-8 octoate and a buffer solution. Arginine residues contained in the hyaluronic acid-arginine graft copolymer in the composition can be specifically combined with integrin receptors (such as alpha v beta 3) highly expressed by fibroblasts at the wrinkle part, so that the exosome can actively anchor the wrinkle part, can be accurately and directionally enriched at the wrinkle part, and is high in utilization rate and high in anti-wrinkle efficiency. The composition constructs a three-dimensional anti-wrinkle network of mesenchymal stem cell exosome, acetyl tetrapeptide-5 and resveratrol, skin collagen degradation and oxidative damage are effectively restrained, and generation of skin wrinkles is blocked through multiple channels.

The invention relates to the technical field of sensors, in particular to a strain sensor based on a multi-layer wrinkled structure and a preparation method and application thereof.The sensor simulates a skin wrinkled structure and belongs to a capacitive sensor, the sensor comprises a flexible medium insulating tape and two layers of flexible layered film electrodes, the flexible layered film electrodes are respectively positioned on two sides of the flexible dielectric insulating tape and cover the flexible dielectric insulating tape, and the flexible layered film electrodes are formed by combining a platinum-modified copper nanowire film (Cu (at) Pt film) with a flexible substrate material polyvinylidene fluoride (PVDF) as a conductive layer. The sensor has high sensitivity and a wide stretching range, overcomes the defects in existing material selection, and has potential application in the fields of exercise monitoring, health monitoring and information transmission.

The invention provides an anti-aging composition containing schizophyllan, a medical beauty injection preparation and application of the anti-aging composition and the medical beauty injection preparation, the anti-aging composition comprises hyaluronic acid or salt of the hyaluronic acid, the schizophyllan and mannitol, and the mass ratio of the hyaluronic acid or the salt of the hyaluronic acid to the schizophyllan to the mannitol is (0.2-3): (0.01-0.5): (0.5-5). According to the anti-aging composition disclosed by the invention, through the multi-component synergistic effect of the schizophyllatin, the hyaluronic acid or the salt thereof and the mannitol, the proliferation activity of fibroblasts can be remarkably improved, and the synthesis and expression of collagen can be efficiently promoted, so that the depth and the quantity of skin wrinkles are effectively improved, and the compactness and the elasticity of the skin are remarkably enhanced; the comprehensive skin rejuvenation effect is realized.

An anti-aging injection composition, an anti-aging injection, and use thereof. The anti-aging injection composition contains hyaluronic acid or a salt thereof, glycine, proline, lysine hydrochloride, and leucine, which can synergistically promote the generation of collagen and elastin in the skin, thereby helping to correct skin wrinkles, improve skin elasticity, and enhance skin radiance. The anti-aging injection composition can be used to prepare an anti-aging injection, which has the effect of resisting skin aging.

The present invention relates to a compound of formula (I) R1-Wm-Xn-AA1-AA2-AA3-AA4-Yo-Zp-R2, stereoisomers and / or cosmetically acceptable salts thereof, in which: AA1 is Leu, Ile or Val; aA2 is Pro, Ala or Gly; aA3 is Val, Ile or Leu; aA4 is Thr, Val or a non-amino acid. The compounds are useful for treating and / or preventing symptoms of skin aging, and in particular for treating and / or preventing skin wrinkles, improving or maintaining skin compactness, treating and / or preventing the appearance of skin sagging, and / or lifting skin.

The present invention relates to a composition comprising a mixture of exosomes derived from different cells, as an active ingredient and use thereof. More specifically, the present invention relates to a composition for treating skin diseases and / or improving skin conditions, comprising, as an active ingredient, mixed exosomes or fused exosomes in which natural killer cell-derived exosomes and mesenchymal stem cell-derived exosomes are mixed or fused. The composition according to the present invention exhibits an excellent cell proliferation effect and the effect of promoting collagen production, and thus can be effectively used as not only a cosmetic material for improving skin conditions, such as by reducing skin wrinkles, regenerating wounds, and increasing elasticity, but also a pharmaceutical material for preventing or treating skin diseases such as atopic dermatitis.

The present invention relates to hybrid exosomes, a use of the same, and a preparation method of the same, and the hybrid exosomes provided from the present invention have excellent skin inflammation amelioration, skin wrinkle amelioration, skin moisturization efficacy, and skin regeneration efficacy compared to using hydrangea-derived exosomes and liposomes alone, and thus can be effectively utilized as a cosmetic composition containing the same as an active ingredient. In addition, the hybrid exosomes have better stability and biocompatibility compared to existing exosomes.

The invention relates to a tightening and lifting mask and a preparation method thereof. The mask liquid comprises the following functional components: saccharomycetes / rice fermentation product filtrate, palmitoyl tripeptide-5 and fibronectin, the mass ratio of the saccharomycetes / rice fermentation product filtrate to the palmitoyl tripeptide-5 to the fibronectin is (0.1-30): (0.01-6): (0.01-2). Compared with the prior art, through the synergistic effects of the saccharomycetes / rice fermentation product filtrate, palmitoyl tripeptide-5 and fibronectin on the aspects of enhancing the skin barrier function, promoting collagen generation, slowing down collagen decomposition, regulating adhesion, migration and proliferation of cells, removing reactive oxygen free radicals and the like, collagen generation of the corium layer is promoted, and the skin care effect is achieved. Skin wrinkles are reduced, and a long-term tightening and lifting effect is achieved.

The invention provides oral recombinant human elastin capable of repairing skin subacute aging injury and application of the oral recombinant human elastin, and belongs to the technical field of biotechnology and functional food. The oral recombinant human elastin capable of repairing skin subacute aging injury is prepared in a gene recombination expression mode. The recombinant human elastin has both a beta-spiral hydrophobic structure domain and a lysine-rich hydrophilic region, and shows excellent biological safety and biological activity; after the traditional Chinese medicine composition is prepared into an oral preparation, skin wrinkles can be remarkably reduced, the skin water content and dermis density can be improved, transdermal water loss can be reduced, the hydroxyproline level can be increased, collagen generation can be promoted, elasticity can be recovered, and skin oxidative stress reaction can be effectively inhibited. The method solves the problems that the natural elastin source is limited and the biological safety is insufficient, and has a wide industrialization prospect.

The present invention relates to a composition comprising plant extracts. The composition according to the present invention has a skin whitening effect by reducing the total amount of melanin and tyrosinase activity in melanocytes of the skin, promotes skin regeneration and increases skin elasticity or reduces skin wrinkles by promoting collagen synthesis and inhibiting collagenase activity in fibroblasts of the skin, has an anti-inflammatory effect or a skin soothing effect by inhibiting NO generation, increases the amount of moisture in the skin and has a moisturizing effect by promoting generation of hyaluronic acid in fibroblasts, and has an antioxidant effect by scavenging free radicals. In addition, since the composition of the present invention exhibits a broad antibacterial effect against various bacteria, the composition may be used as a cosmetic composition, a pharmaceutical composition, a skin external preparation, or a food composition.

This invention discloses a strain of Bifidobacterium animalis subspecies TRT-2A with allergy-relieving effects and its extracellular vesicle applications. The strain TRT-2A is deposited at the China Center for Type Culture Collection (CCTCC) on November 21, 2025, with accession number CCTCC NO:M 20252645. This strain is highly acid-resistant and exhibits good tolerance to artificial gastric and intestinal fluids. It effectively inhibits bacteria, particularly Streptococcus pyogenes, Streptococcus agalactiae, and / or Escherichia coli. Experimental results show that this strain can alleviate hormone-dependent dermatitis and effectively improve dermatitis symptoms such as erythema and desquamation. Furthermore, extracellular vesicles prepared using TRT-2A can effectively improve skin elasticity and reduce wrinkles. Therefore, the Bifidobacterium animalis subspecies TRT-2A of this invention has multiple functions and is worthy of further promotion and application.

The present invention relates to a cosmetic composition for skin elasticity enhancement, skin wrinkle alleviation, and skin whitening, comprising a fermented extract of Perilla frutescens var. acuta Kudo as an active ingredient. The cosmetic composition comprising a fermented extract of Perilla frutescens var. acuta Kudo as an active ingredient, according to one embodiment of the present invention, comprises components derived from natural products and thus is harmless to the human body and exhibits remarkable efficacy in increasing collagen production and ability to inhibit melanin production, thereby being useful for skin elasticity enhancement, skin wrinkle alleviation, and skin whitening.

The present invention relates to a cosmetic composition for improving skin and a pharmaceutical composition for preventing or treating skin damage, each comprising honokiol and polyol. When dissolved in polyol, honokiol enhances anti-wrinkle, elasticity, moisturization, barrier improvement, anti-inflammatory, and antioxidant activities, and thus can be advantageously applied to the production of cosmetic compositions for skin improvement or pharmaceutical compositions for preventing or treating skin damage.

The invention relates to the field of beauty, in particular to a beauty product and application thereof. In particular, the present invention relates to a cosmetic product comprising a concentrate and ultrasonically treated hyaluronic acid, the hyaluronic acid having an average molecular weight in the range of from 100 kD to 500 kDa; wherein the concentrate comprises at least one growth factor and at least one cytokine. The invention also relates to the use of said cosmetic product for promoting tissue regeneration, improving skin quality, reducing skin wrinkles and scars, and reducing skin irritation and flaws.

The invention discloses a firming and anti-wrinkle composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The firming and anti-wrinkle composition provided by the invention is prepared from the following components in parts by mass: 0.0001 to 0.005 part of platinum powder, 0.0001 to 18 parts of palmitoyl pentapeptide-4, 0.0001 to 10 parts of carnosine, 0.0001 to 1 part of a brassica juncea extract and 0.0001 to 3 parts of a guava leaf extract. According to the firming and anti-wrinkle composition provided by the invention, the components in a specific mass part range are selected, and the components have good interaction, so that the firming and anti-wrinkle composition can be used for effectively firming skin, increasing skin elasticity and reducing skin wrinkles when being applied to cosmetics, and also has an excellent moisturizing effect and an excellent skin color brightening effect. Meanwhile, the preparation method of the firming and anti-wrinkle composition provided by the invention is simple to operate, wide in raw material source and beneficial to actual production.

The present invention relates to a novel use of a mitochondria-derived peptide with high skin permeability and, more particularly, to a composition for reducing skin wrinkles or whitening skin comprising the peptide. The mitochondria-derived peptide according to the present invention not only exhibits high skin permeability but also excellent wrinkle reduction and whitening effects, and thus can be variously used in the cosmetic and food fields related to skin wrinkle reduction or skin whitening.

The utility model discloses an excrement and urine collecting bag, which particularly relates to the technical field of medical instruments and comprises a soft application, a bag body with two openings, a first one-way valve hole in butt joint with an injector and a second one-way valve hole in butt joint with a drainage tube. One opening of the bag body is fixedly connected with the soft application, the other opening of the bag body is fixedly provided with a sealing clip, the first one-way valve hole and the second one-way valve hole are both fixedly formed in the position, close to the soft application, of the bag body, and a drainage connector is fixedly installed at the position, close to the sealing clip, of the bag body; and a leakage-proof mechanism and a sticking mechanism are arranged on one side, far away from the bag body, of the soft application. The design that the base plate is replaced by the soft application is adopted, the soft application is made of soft materials, skin protection factors are sprayed in the soft application, and therefore the soft application has the advantages of being light, thin and skin-friendly, foreign body sensation can be reduced, and the skin can be protected; the butterfly-shaped application is adopted as the soft application, so that the soft application is better attached to the skin, and fixation is prevented from being affected by skin wrinkles or secretions.

The present application provides a kind of human umbilical cord mesenchymal stem cell secretory exosome and anti-aging essence based on the exosome and its preparation method and application.By activating Wnt / β-catenin signaling pathway, the yield of exosome and the secretion amount of miR-21 are significantly improved, and the purity and biological activity of exosome are effectively purified by using microfluidic technology. The essence formula contains exosome, HA-Lipo composite carrier, asiaticoside microspheres and dipropylene glycol, and has good skin repair and anti-aging effect. Animal experiments have verified that the essence of the present application can effectively improve skin wrinkles, epidermal thickness and skin barrier function in UVB-induced skin photoaging model, and its molecular mechanism is related to the regulation of collagen metabolism. The essence has significant application prospect in the field of skin beauty and anti-aging.