88 results about "Skin wrinkle" patented technology

It relates to Centella asiatica-derived exosomes, which is useful in the treatment and / or care of skin. In particular, Centella asiatica-derived exosomes is effective in enhancing skin whitening, reducing skin wrinkles, enhancing skin hydration, and improving skin antioxidant capacity.

The invention relates to the technical field of cosmetics, in particular to an efficient anti-aging composition and a skin care product containing the composition. The invention discloses an efficient anti-aging composition which is prepared from the following raw materials in parts by mass: 12-15 parts of oil-based concentrated active ingredients, 25-35 parts of base collagen liquid, 15-18 parts of Ectoine, 12-16 parts of TWEEN 20 and 22-25 parts of isosorbide dimethyl ether, and the oil-based concentrated active ingredients are prepared from safflower seed oil, an extract of flowers / leaves / stems of herba lysimachiae, an extract of radix astragali membranaci, ubiquinone and vitamin E; the base collagen liquid comprises XVII type collagen, VII type collagen and IV type collagen. Aiming at the problems that an existing skin care product cannot effectively reduce skin wrinkles, improve skin compactness, reduce skin sagging and prevent skin aging for a long time, the composition disclosed by the invention realizes long-term aging resistance from epidermis to dermis, effectively reduces wrinkles, improves compactness and improves skin sagging.

To provide a composition for external use on the skin for reducing skin wrinkles containing polyvinyl alcohol, and more particularly, a composition excellent in reducing skin wrinkles by sustainably contracting the skin only by drying after application to the skin without a separate film, by containing a high molecular weight polyvinyl alcohol.SOLUTION: The composition according to the present disclosure can reduce skin wrinkles without side effects and at a lower cost compared to conventional wrinkle-improving treatments.SELECTED DRAWING: Figure 1

The invention discloses application of tea extracellular vesicles in preparation of a product for preventing and / or treating UVB-induced skin photoaging, and belongs to the technical field of application of the tea extracellular vesicles. The tea extracellular vesicles are derived from tea leaves and / or stem leaves and are prepared by a method of combining enzymolysis, multi-stage filtration and ultracentrifugation, and the particle size of the tea extracellular vesicles is mainly distributed in a range of 60-100nm. Experiments show that the tea extracellular vesicles can effectively reduce active oxygen accumulation and lipid peroxidation caused by UVB radiation, repair mitochondrial membrane potential and inhibit expression of matrix metalloproteinase and inflammatory factors, so that photoaging symptoms such as skin wrinkles, erythema and barrier function damage are relieved. The tea extracellular vesicle provided by the invention has the advantages of natural raw materials, good biocompatibility, small side effect and the like, can be used for preparing a plurality of external dosage forms such as gel, cream, spray and the like, and provides a safe and effective new natural product choice for prevention and treatment of skin photoaging.

The invention belongs to the technical field of mesenchymal stem cell exosome compositions, and discloses a preparation method and application of a mesenchymal stem cell exosome composition. The mesenchymal stem cell exosome composition is prepared from a mesenchymal stem cell exosome, a hyaluronic acid-arginine grafted copolymer, acetyl tetrapeptide-5, resveratrol, mannose, polyglycerol-8 octoate and a buffer solution. Arginine residues contained in the hyaluronic acid-arginine graft copolymer in the composition can be specifically combined with integrin receptors (such as alpha v beta 3) highly expressed by fibroblasts at the wrinkle part, so that the exosome can actively anchor the wrinkle part, can be accurately and directionally enriched at the wrinkle part, and is high in utilization rate and high in anti-wrinkle efficiency. The composition constructs a three-dimensional anti-wrinkle network of mesenchymal stem cell exosome, acetyl tetrapeptide-5 and resveratrol, skin collagen degradation and oxidative damage are effectively restrained, and generation of skin wrinkles is blocked through multiple channels.

The invention provides an anti-aging composition containing schizophyllan, a medical beauty injection preparation and application of the anti-aging composition and the medical beauty injection preparation, the anti-aging composition comprises hyaluronic acid or salt of the hyaluronic acid, the schizophyllan and mannitol, and the mass ratio of the hyaluronic acid or the salt of the hyaluronic acid to the schizophyllan to the mannitol is (0.2-3): (0.01-0.5): (0.5-5). According to the anti-aging composition disclosed by the invention, through the multi-component synergistic effect of the schizophyllatin, the hyaluronic acid or the salt thereof and the mannitol, the proliferation activity of fibroblasts can be remarkably improved, and the synthesis and expression of collagen can be efficiently promoted, so that the depth and the quantity of skin wrinkles are effectively improved, and the compactness and the elasticity of the skin are remarkably enhanced; the comprehensive skin rejuvenation effect is realized.

The invention provides oral recombinant human elastin capable of repairing skin subacute aging injury and application of the oral recombinant human elastin, and belongs to the technical field of biotechnology and functional food. The oral recombinant human elastin capable of repairing skin subacute aging injury is prepared in a gene recombination expression mode. The recombinant human elastin has both a beta-spiral hydrophobic structure domain and a lysine-rich hydrophilic region, and shows excellent biological safety and biological activity; after the traditional Chinese medicine composition is prepared into an oral preparation, skin wrinkles can be remarkably reduced, the skin water content and dermis density can be improved, transdermal water loss can be reduced, the hydroxyproline level can be increased, collagen generation can be promoted, elasticity can be recovered, and skin oxidative stress reaction can be effectively inhibited. The method solves the problems that the natural elastin source is limited and the biological safety is insufficient, and has a wide industrialization prospect.

The present invention relates to a composition comprising plant extracts. The composition according to the present invention has a skin whitening effect by reducing the total amount of melanin and tyrosinase activity in melanocytes of the skin, promotes skin regeneration and increases skin elasticity or reduces skin wrinkles by promoting collagen synthesis and inhibiting collagenase activity in fibroblasts of the skin, has an anti-inflammatory effect or a skin soothing effect by inhibiting NO generation, increases the amount of moisture in the skin and has a moisturizing effect by promoting generation of hyaluronic acid in fibroblasts, and has an antioxidant effect by scavenging free radicals. In addition, since the composition of the present invention exhibits a broad antibacterial effect against various bacteria, the composition may be used as a cosmetic composition, a pharmaceutical composition, a skin external preparation, or a food composition.

This invention discloses a strain of Bifidobacterium animalis subspecies TRT-2A with allergy-relieving effects and its extracellular vesicle applications. The strain TRT-2A is deposited at the China Center for Type Culture Collection (CCTCC) on November 21, 2025, with accession number CCTCC NO:M 20252645. This strain is highly acid-resistant and exhibits good tolerance to artificial gastric and intestinal fluids. It effectively inhibits bacteria, particularly Streptococcus pyogenes, Streptococcus agalactiae, and / or Escherichia coli. Experimental results show that this strain can alleviate hormone-dependent dermatitis and effectively improve dermatitis symptoms such as erythema and desquamation. Furthermore, extracellular vesicles prepared using TRT-2A can effectively improve skin elasticity and reduce wrinkles. Therefore, the Bifidobacterium animalis subspecies TRT-2A of this invention has multiple functions and is worthy of further promotion and application.

The present invention relates to a cosmetic composition for skin elasticity enhancement, skin wrinkle alleviation, and skin whitening, comprising a fermented extract of Perilla frutescens var. acuta Kudo as an active ingredient. The cosmetic composition comprising a fermented extract of Perilla frutescens var. acuta Kudo as an active ingredient, according to one embodiment of the present invention, comprises components derived from natural products and thus is harmless to the human body and exhibits remarkable efficacy in increasing collagen production and ability to inhibit melanin production, thereby being useful for skin elasticity enhancement, skin wrinkle alleviation, and skin whitening.

The invention relates to the field of beauty, in particular to a beauty product and application thereof. In particular, the present invention relates to a cosmetic product comprising a concentrate and ultrasonically treated hyaluronic acid, the hyaluronic acid having an average molecular weight in the range of from 100 kD to 500 kDa; wherein the concentrate comprises at least one growth factor and at least one cytokine. The invention also relates to the use of said cosmetic product for promoting tissue regeneration, improving skin quality, reducing skin wrinkles and scars, and reducing skin irritation and flaws.

The present invention relates to a novel use of a mitochondria-derived peptide with high skin permeability and, more particularly, to a composition for reducing skin wrinkles or whitening skin comprising the peptide. The mitochondria-derived peptide according to the present invention not only exhibits high skin permeability but also excellent wrinkle reduction and whitening effects, and thus can be variously used in the cosmetic and food fields related to skin wrinkle reduction or skin whitening.

The utility model discloses an excrement and urine collecting bag, which particularly relates to the technical field of medical instruments and comprises a soft application, a bag body with two openings, a first one-way valve hole in butt joint with an injector and a second one-way valve hole in butt joint with a drainage tube. One opening of the bag body is fixedly connected with the soft application, the other opening of the bag body is fixedly provided with a sealing clip, the first one-way valve hole and the second one-way valve hole are both fixedly formed in the position, close to the soft application, of the bag body, and a drainage connector is fixedly installed at the position, close to the sealing clip, of the bag body; and a leakage-proof mechanism and a sticking mechanism are arranged on one side, far away from the bag body, of the soft application. The design that the base plate is replaced by the soft application is adopted, the soft application is made of soft materials, skin protection factors are sprayed in the soft application, and therefore the soft application has the advantages of being light, thin and skin-friendly, foreign body sensation can be reduced, and the skin can be protected; the butterfly-shaped application is adopted as the soft application, so that the soft application is better attached to the skin, and fixation is prevented from being affected by skin wrinkles or secretions.

The present application provides a kind of human umbilical cord mesenchymal stem cell secretory exosome and anti-aging essence based on the exosome and its preparation method and application.By activating Wnt / β-catenin signaling pathway, the yield of exosome and the secretion amount of miR-21 are significantly improved, and the purity and biological activity of exosome are effectively purified by using microfluidic technology. The essence formula contains exosome, HA-Lipo composite carrier, asiaticoside microspheres and dipropylene glycol, and has good skin repair and anti-aging effect. Animal experiments have verified that the essence of the present application can effectively improve skin wrinkles, epidermal thickness and skin barrier function in UVB-induced skin photoaging model, and its molecular mechanism is related to the regulation of collagen metabolism. The essence has significant application prospect in the field of skin beauty and anti-aging.

The present invention relates to a composition for improving skin function, containing Lactobacillus plantarum as an active ingredient and, specifically, to a composition having the effects of activating primary cilia, improving skin barrier function, soothing skin, reducing skin wrinkles, whitening skin, and inhibiting melanin production, the composition containing a Lactobacillus plantarum beLP1 strain, a lysate thereof, a culture thereof, a concentrate thereof, a dried product thereof, or dead cells thereof as an active ingredient.

The invention belongs to the technical field of image segmentation, and discloses a lesion image processing system and method based on deep learning, and the method comprises the steps: obtaining a skin image, and extracting a multi-scale hierarchical feature map of the skin image through an encoder; inputting the multi-scale hierarchical feature map into a dual-path processing module, and outputting a first path output feature and a second path output feature; inputting the first path output feature and the second path output feature into a feature fusion module, and performing weighted fusion based on a cross attention mechanism to generate a fusion feature map; and inputting the fused feature map into a segmentation decoder, and outputting a segmented region map of the milk coffee spots after multi-scale context aggregation. According to the method, specific inhibition is performed on skin color variation and skin wrinkle interference, feature complementary fusion is realized in combination with a cross attention mechanism, and multi-scale context information is integrated in a segmentation decoder, so that the accuracy, robustness and generalization ability of a milk coffee spot segmentation task under a complex skin background can be remarkably improved.

The application relates to the cosmetic technical field, in particular to a high-efficiency anti-aging composition and a skin care product containing the same. The high-efficiency anti-aging composition is prepared from the following raw materials in parts by mass: 12-15 parts of oil-based concentrated active ingredients, 25-35 parts of base collagen liquid, 15-18 parts of ikar, 12-16 parts of TWEEN 20, and 22-25 parts of isosorbide dimethyl ether. The oil-based concentrated active ingredients include safflower seed oil, acmella oleracea flower / leaf / stem extract, Astragalus membranaceus (Fisch.) Bunge root extract, ubiquinone and vitamin E. The base collagen liquid includes type XVII collagen, type VII collagen and type IV collagen. The composition can effectively reduce skin wrinkles, improve skin tightness and reduce skin sagging in a long term, and prevent skin aging, and realizes long-term anti-aging from epidermis to dermis.

The utility model provides a composite material T-shaped stringer which comprises a left L-shaped layer plate, a right L-shaped layer plate and a bottom layer plate arranged at the bottom of the left L-shaped layer plate and the bottom of the right L-shaped layer plate, the left L-shaped layer plate and the right L-shaped layer plate are symmetrically arranged relative to the longitudinal center face of the composite material T-shaped stringer, and each of the left L-shaped layer plate and the right L-shaped layer plate comprises a plurality of prepreg laying layers. The left L-shaped laminate and the right L-shaped laminate are respectively provided with edge structures which are positioned at two ends of the composite T-shaped stringer along the width direction of the composite T-shaped stringer, and a plurality of prepreg paving layers in the edge structures are constructed to coat the bottom laminate layer by layer from inside to outside so as to form a wedge-shaped oblique angle structure of which the edges are coated layer by layer; and the tail parts of the plurality of prepreg paving layers in the edge structure are in contact with the bottom laminate. The wedge-shaped oblique angle structure wrapping the edge of the bottom of the T-shaped stringer layer by layer can effectively avoid the skin wrinkling problem of the stiffened wall plate prepared by adopting a dry stringer-wet skin co-bonding forming process, and can also avoid the risk of layering of the edge of the bottom of the stringer.

The present invention addresses the problem of using yeast-derived cell walls to provide a material which has a skin wrinkle improving effect and is further useful as a tactile sensation improver when applied to the skin. The present inventors have completed the present invention by finding that a cosmetic composition having a skin wrinkle improving effect, a moisture retaining effect, and a skin barrier effect can be provided by using a yeast cell wall-containing composition having a yeast cell wall structure, and also can be used as a tactile sensation improving agent through an in-depth study. Further, the composition comprising the yeast cell wall of the present invention can be extracted from a food yeast, and thus belongs to a food microorganism source and can be safely used.

A composition containing iris-derived exosomes as an active ingredient is provided for skin elasticity improvement, skin wrinkle reduction, skin regeneration, skin tone improvement, skin brightness improvement, skin whitening, anti-inflammation, wound healing and / or wound healing acceleration.

The invention discloses a lactobacillus rhamnosus LR-C111 contributing to skin aging resistance and application of the lactobacillus rhamnosus LR-C111. The lactobacillus rhamnosus LR-C111 is classified and named as lactobacillus rhamnosus, the preservation number is CCTCC NO: M 20251647, the preservation unit is China Center for Type Culture Collection, and the preservation time is July 21, 2025. The lactobacillus rhamnosus LR-C111 is named as lactobacillus rhamnosus LR-C111. The lactobacillus rhamnosus LR-C111 can enhance the antioxidant enzyme activity of mouse skin and reduce the generation of oxygen free radicals by inhibiting the expression of MMP-1 and MMP-9 pathways, so as to inhibit the content decomposition of endogenous components in the skin and reduce the loss of skin collagen and the degradation of ECM (extracellular matrix), thereby delaying the skin aging. The composition can be used for preventing, treating and / or improving skin elasticity reduction, skin wrinkles and other symptoms caused by skin photoaging caused by ultraviolet rays.

The present invention relates to a novel anti-aging peptide. It has been experimentally identified that the anti-aging peptide according to the present invention has high skin permeability and has remarkable antioxidant activity, reduces skin wrinkles, improves skin elasticity, and inhibits collagenase or hyaluronidase. Therefore, the anti-aging peptide of the present invention has excellent anti-aging activity, and thus can be variously used as a functional material in the fields of pharmaceuticals, medicinal products, cosmetics and food.

The invention provides an anti-wrinkle composition containing a convalescent tomentosa flower extract and a preparation method thereof, the composition with an anti-wrinkle effect comprises a black willow bark extract, the convalescent tomentosa flower extract, an inula flower extract, a leontopodium alpinum extract and adenosine, and after the raw materials are matched and used for the composition, the anti-wrinkle composition is prepared from the raw materials. The composition can synergistically promote secretion of type I collagen, and has remarkable effects of improving skin elasticity and reducing generation of skin wrinkles.

The utility model discloses a portable travel is with many gears adjusting shower, related to shower technical field, including handle, handle top includes shower nozzle and depth cleaner, and handle outer wall top additionally has a plurality of clamping sliding blocks, and the inner wall bottom of shower nozzle and depth cleaner all are equipped with a plurality of L type clamping components, and the top end fixed connection of handle inner chamber has flow regulating valve, and flow regulating valve outer wall one side is installed valve stem, the utility model discloses can through rotating shower nozzle, separates shower nozzle with handle, replaces depth cleaner, because depth cleaner is cylindrical modeling, makes it better to explore the private place of user, under the action of the release medicine efficacy of impeller assembly and medicine basket inner medicine bag, and water flow is pulsed from the multiple water outlet holes at the front end of depth cleaner and sprays, effective penetration skin wrinkle and secret gap, and through the convex point of depth cleaner outer wall additional rubbing with skin, realize to skin wrinkle and secret gap's thorough cleaning.

The invention discloses a composition for treating skin aging, and the composition specifically comprises an antioxidant, a collagen accelerant, a polysaccharide humectant, a plant extract, a sunscreen protective agent and a synthetic acceleration.According to the composition, the antioxidant is used for effectively reducing the oxidation pressure of skin, protecting the skin from free radical damage, promoting collagen generation and improving the skin aging effect; the skin care product has good skin regeneration capacity, the collagen accelerant can effectively stimulate generation of collagen and elastic fibers, the skin elasticity and compactness are enhanced, generation of skin collagen is promoted, and the skin care product is prepared through the antioxidant, the collagen accelerant, the polysaccharide humectant, the plant extract, the sunscreen protective agent and the synthetic accelerant. According to the invention, multiple functional treatment means of oxidation resistance, collagen promotion, barrier repair and photoprotection are realized, aging characterization of wrinkles, looseness and stains of skin can be systematically and comprehensively improved, efficacy and safety are considered, and the skin treatment effect is effectively ensured.

The polypeptide composition is prepared from the following components in percentage by weight: 0.1 to 20 percent of carnosine, 0.01 to 10 percent of oligopeptide-1, 0.001 to 5 percent of blue copper peptide, 0.001 to 2 percent of DNA (deoxyribonucleic acid) sodium, 0.0001 to 1 percent of red scorpion four-membered cyclic peptide, 28.989 to 45 percent of betaine and 40 to 48.499 percent of sorbitol. Red scorpion four-membered cyclic peptide cooperates with the cell proliferation promoting function of tripeptide-1 copper and oligopeptide-1, the antioxidant effect of carnosine and the effect of DNA sodium activating mitochondrial metabolism to improve cell energy to achieve the synergistic anti-aging effect, betaine and sorbitol construct an ionic liquid synergistic permeation promoting system, and finally the instant-long-acting integrated anti-aging effect is achieved. The functional mechanism of each component is clear in action site, high in activity, high in acting speed, obvious in curative effect and high in safety, an ionic liquid technology and a penetration enhancing system cooperate to help transdermal absorption of polypeptide components, the active efficacy of the polypeptide components can be more easily exerted, the wrinkle condition of the skin can be improved, and the skin elasticity can be recovered.

The application discloses an acetylsalicylic acid modified blue copper peptide derivative with the effects of repairing, wrinkle removing, anti-aging and the like and application thereof. The structure of the acetylsalicylic acid modified blue copper peptide derivative is shown as formula I: R1 is selected from the group consisting of ; and R2 is selected from the group consisting of. The acetylsalicylic acid modified blue copper peptide derivative has the effects of promoting cell proliferation, promoting collagen synthesis, promoting barrier repair, promoting wound healing and reducing the degree of skin wrinkle, and has a lower effective concentration than the original blue copper peptide. The acetylsalicylic acid modified blue copper peptide derivative can be used as a main active ingredient in the fields of medicine and daily chemical products.

This invention relates to a Trolox-peptide conjugate that exhibits activity in relieving muscle contraction and increasing extracellular matrix activity, and that the Trolox-peptide conjugate can be used as an active ingredient in pharmaceuticals, quasi-pharmaceuticals, or cosmetics for the prevention or treatment of muscle relaxation, neuromuscular disorders, or to improve skin conditions including wrinkles.

The application discloses an injection cosmetic filling material which is composed of the following components in percentage by mass: 10-40 parts of hydroxyapatite microspheres, 60-90 parts of gel liquid, 2-5 parts of gradient cross-linking modified sodium hyaluronate, 0.5-1 part of vitamin E-tea seed oil-panthenol compound microemulsion and 0.5-1 part of hyaluronic acid-proline graft copolymer. The application further discloses a preparation method of the injection cosmetic filling material, which comprises the following steps: S1, synthesizing hydroxyapatite; S2, preparing hydroxyapatite microspheres; and S3, stirring and mixing. The hydroxyapatite microsphere gel of the application has a good biocompatibility and a good stable filling system, solves the problem of poor compatibility between a thickening agent and a matrix, can be kept in a plastic part for a long time after injection, can provide long-acting filling and support to improve the skin wrinkle effect in the tissue, can provide nourishing repair and deep moisturizing functions at the same time, has the effects of filling and repair, and delays facial aging.

The present invention provides a skin filler and a method for treating wrinkles in a patient's skin. [Solution] A polymer matrix is ​​provided which contains lysine, hyaluronic acid, and collagen, wherein the hyaluronic acid and collagen form a hydrogel, and the polymer matrix does not contain chitosan.