106 results about "Skin photoaging" patented technology

The invention relates to a composition for topical application or oral administration, containing an effective quantity of at least one inhibitor of the enzyme 3beta-hydroxysteroid dehydrogenase. This composition is designed in particular for the treatment of certain effects of chronological ageing and photo-ageing of the skin.

The objective of the invention is to provide a photo-aging prophylactic agent for skin with novel ingredients and foods using the photo-aging prophylactic agent for skin, medicaments for mammals including human beings and a skin external agent, as well as feed for mammals. The inventive photo-aging prophylactic agent for skin is characterized by taking extracts of Orobanchaceae plants as effective ingredients. The photo-aging prophylactic agent for skin preferably comprises phenylethanoid glycosides compounds as effective ingredients. Moreover, the photo-aging prophylactic agent for skin preferably comprises at least one of echinacoside and acteoside as the phenylethanoid glycosides compounds. On top of that, the photo-aging prophylactic agent for skin preferably comprises both echinacoside and acteoside as the phenylethanoid glycosides compounds. In addition, the photo-aging prophylactic agent for skin can be employed as medicaments for mammals including human beings, skin external agents, consumptive foods and feed for mammals.

Compositions and methods are provided for ameliorating various effects of UVA and UVB radiation from the sun. The compositions include an ingredient that prevents photoaging from MED and subMED radiation, namely a direct acting MMP (matrix metalloproteinase) inhibitor. The compositions can include another, indirect MMP inhibitor, such as a retinoid, certain other compounds (such as N-acetylcysteine, 2-furildioxime, and vitamin C), tetracyclines, and if a retinoid is used then in addition optional compounds that inhibit the CYP-26 (chytochrome P-450) mediated metabolism of retinoids such as ketoconazole and other azole compounds. In the method, the composition is applied prior to exposure to the sun; for direct acting MMP inhibitors, application should be just prior to exposure, and if indirect inhibitors such as retinoids are used in addition, then application of the indirect inhibitor should be at least about seven hours prior to exposure. Compounds that prevent erythema (skin reddening, sunburn) do not necessarily protect against UV-mediated elevation of MMP levels and activity, and similarly compounds that prevent UV-mediated elevation of MMP levels and activity are not necessarily effective against UV-induced erythema.

The invention is concerned with the Chinese traditional medicine combination for staying anile of skin that combinates by active constitutent and the acceptable supplementary meterials medically. The active constitutent prepares by the materials with weight ratio: ass-skin glue is 5 to 10 shares, astraolylis lancea formalyrata is 3 to 6 shares, tuckahoe is 3 to 6 shares, longan aril is 5 to 10 shares, and amomum fruit is 2 to 5 shares. The invention is with better effect with native caducity and photoaging, which can stay native caducity and photoaging; the invention can improve the substrate hyaluronic acid in order to increase the humidity of the skin; the invention is without side effect.

The present invention relates to a composition for the skin whitening and wrinkle improvement, comprising an extract of Vaccinium uliginosum as an active ingredient. The Vaccinium uliginosum extract has the effects of inhibiting and scavenging reactive oxygen species produced in skin tissue as a result of ultraviolet irradiation to the skin, effectively inhibiting tyrosinase activity to inhibit the production of melanin in melanin cells, inhibiting the secretion of cytokines in keratinocytes, promoting the production of procollagen, and inhibiting the decomposition of collagen. Thus, the extract will be useful for the prevention of skin photo aging caused by ultraviolet radiation, the enhancement of skin whitening and the improvement of wrinkles. In addition, the Vaccinium uliginosum extract is suitable to use as a component for improving skin wrinkles in cosmetics, foods and drugs, because the Vaccinium uliginosum extract can achieve the effect of improving skin conditions, even when it is applied to the skin or used internally.

The invention belongs to the cosmetics field, and particularly relates to a composition with after-sun repair, antioxidant and whitening effect and its preparation method. The composition is preparedby taking tricholoma matsutake, lucid ganoderma, tremella and other fungus drugs. The composition is prepared from, by weight, 0.5-5 parts of tricholoma matsutake, 0.5-5 parts of lucid ganoderma, and0.5-5 parts of tremella. The composition takes three nature mushroom type drug extractives of tricholoma matsutake, lucid ganoderma, tremella as main active matters; the prepared composition can be applied to skincare; compared with the independent use of tricholoma matsutake, lucid ganoderma, or tremella, the composition can obviously lighten the light injuiry of HaCaT cell induced by UVB, and has obvious skin light aging resistance; therefore, the composition has the after-sun repair effect; the composition also can effectively remove DPPH free radicals and hydroxyl radical, good antioxidantand clear anti-aging effect. The composition can obviously inhibit activity of monophenyl oxidase, inhibit generation of melanin in melanoma cell, and further play the whitening effect; therefore, the composition has clear whitening effect.

The invention relates to preparation and application of a skin-photoage-resisting Chinese herbal compound extractive. According to the Chinese herbal compound extractive, ten traditional Chinese medicines namely angelica sinensis, ligusticum wallichii, bighead atractylodes rhizome, poria cocos, astragalus membranaceus, codonopsis pilosula, peach kernel, Chinese yam, radix paeoniae alba and honey-fried licorice root are taken as raw materials, and the skin-photoage-resisting Chinese herbal compound extractive is extracted and prepared through a supercritical CO2 extraction technique according to certain technological parameters. The preparation method is simple, the conventional purification and refining process in extraction is omitted, the original characteristics of all the components are furthest maintained, effective components are highly concentrated, and the bioavailability is high. The extractive has remarkable effects of scavenging free radical, resisting oxidative damage and enhancing skin elasticity, and can be directly and safely used for preparing anti-skin photoage external preparations and cosmetics.

The invention discloses bifidobacterium breve with effects of repairing ultraviolet injury, relieving inflammation and preventing skin light aging, and a preparation method and application thereof, and relates to the technical field of microorganisms. The bifidobacterium breve with the effects of repairing ultraviolet injury, relieving inflammation and preventing skin light aging provided by the invention is characterized in that the bifidobacterium breve is named as bifidobacterium breve, and has a preservation number of CGMCC No.12915. Test results show that the bifidobacterium breve provided by the invention has the effects of repairing skin injury and inflammation caused by ultraviolet rays, and can relieve a skin light aging phenomenon caused by long-time repeated irradiation by the ultraviolet rays.

The invention discloses an application and use method of salidroside in preparing a skin-care product for preventing skin photoaging. When the skin-care product is prepared, the salidroside can be taken as an active matter and prepared into a salidroside liposome with the grain diameter less than 200 nanometers, and the mass percent concentration of the salidroside liposome is 0.01%-10%. According to the application and the use method disclosed by the invention, the influence of the salidroside on the expression of a UVB (Ultraviolet B) induced skin keratinocyte photoaging key gene is inspected, a test result indicates that the skin-care product effectively inhibits the degradation of collagen and the inflammatory reaction of cells and achieves the effect of preventing the skin photoaging; the salidroside is one of main components of rhodiola sachalinensis, and the salidroside can be directly added to the skin-care product for preventing the skin photoaging, or a salidroside extract which contains the salidroside can be indirectly added to the skin-care product for preventing the skin photoaging.

The invention discloses an integral floating electrode plasma cosmetic instrument mainly comprising an integrated case and a handheld electrode. The integrated case comprises a power supply module, a high-voltage connection module and a control display module. 220V alternating current is processed to generate high-voltage pulse by the power supply module, and generation efficiency and temperature of plasma can be regulated by regulating power of the high-voltage pulse. At the ambient environment, the human body is taken as the floating electrode to discharge to generate plasma directly contacting with the human body when the handheld electrode is 1-2 micrometers spaced from the human body. The integral floating electrode plasma cosmetic instrument has the advantages of simplicity in use, convenience in moving, high efficiency and safety, and the like, and further has great effects in improving actinic and aged skins and skins with cutis laxa, reducing face wrinkles and removing traumatic or mesh grafting scars.

The invention discloses an application and use method of ligustilide in preparing a skin-care product for preventing skin photoaging. When the skin-care product is prepared, the ligustilide is taken as an active component and prepared into a ligustilide nano-liposome or nano-emulsion with the grain diameter less than 200 nanometers, and the mass percent concentration of the ligustilide nano-liposome or the nano-emulsion is 0.01%-10%. According to the application and use method disclosed by the invention, the influence of the ligustilide on the expression of a UVB (Ultraviolet B) induced skin keratinocyte photoaging key gene is inspected through a UVB induced skin keratinocyte model test, and a test result indicates that the skin-care product can effectively inhibit the degradation of collagen and the inflammatory reaction of cells and achieve the effect of preventing the skin photoaging; the ligustilide widely exists in angelica root volatile oil or cnidium officinale root volatile oil, and the ligustilide is directly added to the skin-care product for preventing the skin photoaging, or the angelica oil or cnidium officinale oil which contains the ligustilide is indirectly added to the skin-care product for preventing the skin photoaging.

The invention relates to a light aging resistant composition and application thereof to essence. A product uses glycogen, Ectoin, cluster pine bark extracts, beta-glucan and glycerinum as raw materials; proper weight proportioning is performed; various substances achieve a cooperated effect; the finally prepared light aging resistant composition can resist light pollution from the inside of the skin; the free radical formation is reduced; damaged cell DNA is restored; the formation of inflammation and red spots can be inhibited; the generation of cell ATP, hyaluronic acid, ceramide and antioxidation protein can be promoted; the skin light aging can be actively resisted. The obtained composition is safe, mild and inirritative, and is applicable to any kinds of skin. According to light agingmechanisms, the product aims at each link causing the skin damage, can safely, effectively and actively solve the light aging problem to restore the cell activity and to promote collagen synthesis, so that winkles are reduced. The composition has the advantages that the preparation method is simple; the addition into a recipe is easy; the light aging problem is effectively solved.

The invention discloses a probiotic mask, which comprises the following components by weight percentage: 1 to 5% of a fermentation product filtrate of bifida, 0.5 to 3% of a lactic acid bacteria fermentation lysate, 0.45 to 1.125% of alpha-glucan oligosaccharide, 0.5 to 5% of trehalose, 0.1 to 2% of a saccharide isomerate, and 0.1 to 2% of glycosphingolipid. The probiotic mask of the present invention is added with the fermentation product filtrate of bifida which is a probiotic product for repairing skin photoaging as well as a lactic acid bacteria fermentation lysate which is the probiotic product for promoting the exfoliation of the dead skin. The two probiotic products can repair damaged skin from the inside to outside; the addition of the moisturizing ingredients of alpha-glucan oligosaccharide, trehalose, the saccharide isomerate and glycosphingolipid can effectively moisturize the stratum corneum of the skin, and the combination of the probiotic product and the moisturizing ingredients enables the mask of the present invention to have a good skin repairing effect and a long-lasting moisturizing power.

The invention discloses an early anti-aging and brightening nutrient containing a melaleuca bracteate extract. The early anti-aging and brightening nutrient comprises the following components in partsby weight: 1-10 parts of polyol, 1-10 parts of a moisturizer, 2-20 parts of an emollient, 1-5 parts of an emulsifier, 0.1-2 parts of a thickener, 0.1-2 parts of a pH regulator, 0.1-5 parts of an antioxidant, 0.1-10 parts of a skin conditioner and 80-100 parts of deionized water, wherein the skin conditioner contains the melaleuca bracteate extract. According to the early anti-aging and brightening nutrient, the melaleuca bracteate extract is added to various assistants, so that skin photoaging is effectively prevented, balance of melanocytes is restored, natural color and luster of skin are restored, wrinkles are significantly reduced and the elasticity of the skin is increased.

The invention provides a preparation method of a polypeptide for inhibiting activity of matrix metalloproteinase in photo-aged skin; by taking fish skin as a raw material, an enzyme sensor-artificial neural network online monitoring model is established through a combined enzyme of alkaline protease and pancreatin to control a hydrolysis progress, so that hydrolysis degree is 18%-19%; an enzymatic hydrolysis solution is filtered by virtue of a microporous filtering membrane of 0.22 micron and active peptide with molecular weight cutoff ranging from 300Da to 1000Da is ultra-filtered by virtue of a spiral-wound ultrafiltration membrane; and finally, the peptide is subject to sequential separation and purification by virtue of an SP-Sephadex C25 cation exchange column and a Sephadex G25 gel column, and the peptide is freeze-dried so as to obtain a target antagonist peptide that a main feature segment is Gly-Pro matrix metalloproteinase (MMPs). The fish skin gelatin derived bioactive peptide prepared by the invention is capable of significantly inhibiting the increase in skin MMPs content caused by ultraviolet ray and is relatively good in anti-oxidative activity; and the antagonist peptide provides a wider prospect for the development and utilization of active peptide which is prepared from fish skin gelatin and has photo-aging resisting activity for skin.

The invention provides a skin barrier repairing compound, a skin care lotion and a preparation method thereof. The skin barrier repairing compound comprises a composition for repairing a skin barrier,a centella extract, an aloe vera leaf extract, a bearberry leaf extract, a glycyrrhiza inflata root extract and an oat protein extract, wherein the composition for repairing the skin barrier comprises a hypecoum maritimum callus culture filtrate, ectoine and a hydrolyzed red algae extract. The skin barrier repairing compound has the effect of repairing the skin barrier, and can also resist excessive free radicals, improve the antioxidant capacity of the skin, inhibit melanin pigmentation and promote metabolism of the skin. The skin care lotion prepared from the skin barrier repairing compoundhas obvious whitening and repairing effects, can effectively improve skin photoaging, help cell saccharification and reversion and promote skin collagen, and has the effects of slowing down skin aging, improving color spots, whitening and brightening the skin and reducing wrinkles.

The invention discloses a sun protection and skin care cosmetic composite and an application of the composite in a sun protection emulsion. The composite comprises the following components: kojic acid, a radix scutellariae extract, a grape pip extract, an aloe extract, a honeysuckle extract and a cardiospermum halicacabum extract. A natural sun protection agent of a product can alleviate radiation damage of ultraviolet rays on skin by an oxidation or radical resistance effect, so that the sun protection performance of the product is indirectly improved and a light ageing phenomenon of the skin is slowed; raw materials highly absorb the ultraviolet rays and protect against the damage caused by the ultraviolet rays, and the effective components are scientifically compatible, so that an SPF (Sun Protection Factor) value of the product is higher, and the product is endowed with a high-efficiency sun protection effect; and in addition, the stimulation on the skin is low and an oil phase with good permeability and spreadability is compatible with the sun protection agent, so that the sun protection agent is better fixed on the skin, and the acting time of the sun protection agent is longer.

The invention discloses an anti-light aging preparation for the skin, wherein the preparation comprises royal jelly acid (10-HAD) and AA-2G. Meanwhile, the invention further discloses application of royal jelly acid and AA-2G in preparation of skin care products, cosmetics and cosmeceuticals. The anti-light aging preparation can substantially improve activity of cells irradiated by UVA, inhibits UVA-induced ROS generation and UVA-induced cell aging and has a substantial anti-light aging effect. According to research on action mechanism of the anti-light aging preparation, 10-HDA included in the anti-light aging preparation can inhibit activation of p-JNK and p38 MAPK signaling pathways and reduce expression of UVA-induced MMP-1 and MMP-3, so the content of collagen in cells can be increased; thus, the preparation is an effective anti-light aging preparation for the skin.

The invention discloses a sunscreen skin care product additive which is dextran. Accordingly, the inventor also prepares a corresponding sunscreen skin care product and a preparation method thereof. The obtained product has the characteristics of being good in sunscreen effect and being safe, comfortable and non-irritant. Tests show that due to the unique function of the dextran, the sunscreen skin care product has the advantages of effectively relieving light aging of the skin and making up for the problems that the traditional sunscreen cream is strong in decorous feeling, easy in blocking of pores, irritant for skin, insufficient in persistence, low in comfort and the like; meanwhile, the moisture level of the product can be improved, so that the requirements of consumers can be met toa higher degree.

The invention discloses application of semen coicis oil to preparation of medicine for treating inflammatory and pruritic skin diseases and improving of skin water contents or repairing of skin matrix light damage. The invention further discloses a semen coicis oil emulsification preparation and a preparing method of the semen coicis oil emulsification preparation. Tests prove that the semen coicis oil can evidently improve the skin water contents, repair the skin matrix light damage and effectively resist skin photoaging; the semen coicis oil is good in curative effect on the dry and pruritic skin diseases, skin pruritus can be relieved evidently, barrier repairing can be promoted, and skin thickening and lichenification can be relieved.

The invention discloses a costuslactone composition for preventing skin photoaging and an application method of the costuslactone composition. The costuslactone composition is prepared by combining costene lactone and dehydro-costuslactone according to a mass ratio of 1: (0.4-2.5); when being used for preparing a cosmetic for preventing skin photoaging, the costuslactone composition can be prepared into lipidosome or nano emulsion with the particle size less than 200nm, and is further added into a cosmetic product. A UVB (Ultraviolet B) induced skin keratinocyte module experiment researches the expression influence of the costuslactone composition on key UVB costuslactone composition photoaging genes, and the experiment result shows that the costuslactone composition can effectively inhibit degradation of collagen and macrophage inflammatory reaction, and an effect of preventing skin photoaging is achieved. The costuslactone composition widely exists in essential oil of a traditional Chinese medicine saussurea costus, and the costuslactone composition can be directly added or the saussurea costus essential oil with the costuslactone composition of a certain ratio can be indirectly added into the cosmetic for preventing skin photoaging.

The invention discloses a composition for brightening and resistance to skin light aging, and application thereof. At first, the invention discloses the composition for brightening and resistance to skin light aging. The composition is prepared from the following components in mass: 0.001%-10% of a ginseng extract, 0.01%-10% of a lucid ganoderma extract, 0.001%-10% of a herba portulacae extract, 0.001%-10% of a mulberry extract, 0.001%-0.5% of carnosine or a nano-scale intermediate thereof, as well as 0.001%-5% of arginine PCA or a nano-scale intermediate thereof. A cosmetic product prepared from the composition is resistant to harm from a natural environment, especially sunlight, can prevent formation of free radicals, lipid peroxidation and formation of late AGEs, can realize effects ofbrightening and firming of skin subject of light aging as proved in clinical testing, and can to some extent reduce melanogenesis, relieve erythema, make the skin color uniform and make the skin lookwhite and young.

The invention discloses a composite nano-particle for resisting skin photoaging, tetrahydrocurcumin is embedded in a zein and hyaluronic acid composite particle, the nano-particle in which zein and tetrahydrocurcumin are coated with hyaluronic acid is prepared through an anti-solvent technology, the particle size of the nano-particle is smaller than 300 nm, and the molecular weight of hyaluronic acid is 100 kDa; the invention also discloses a preparation method of the composite nanoparticle for resisting skin photoaging. The preparation method comprises the following steps: S1, adding the zein and the tetrahydrocurcumin into an ethanol solution; preparing a hyaluronic acid aqueous solution; S2, mixing the obtained alcoholic solution with a hyaluronic acid solution; and S3, evaporating and centrifuging the obtained mixed solution, and then carrying out post-treatment to obtain composite nanoparticles. The composite nanoparticles can effectively inhibit apoptosis of epidermal cells and inflammatory response of cells, improve hyperkeratinization of skin induced by UVB, and achieve the effect of preventing skin photoaging.

The invention relates to application of total astragaloside to anti-photoaging and photodamage of skin. The total astragaloside can improve the photoaging caused by long-term repeated irradiation of UVB (Ultraviolet B). As proved by cell level experiments, the total astragaloside has good effects in anti-oxidation, anti-photodamage, anti-photoaging, protection of mitochondria and inhibition of apoptosis induced by the UVB and the like. Meanwhile, the total astragaloside can also reverse the loss process of collagen in skin cells during photoaging, and promote the accumulation of collagen. On the other hand, the autophagy activity of photoaging cells can be up-regulated, and the normal cell homeostasis process is maintained so as to better resist the photoaging process. The total astragaloside is proved to have a good effect in the anti-skin photoaging process, and can be applied in the fields of pharmaceutical, health care products, cosmetics and the like.