139 results about "Pharmaceutical engineering" patented technology

The invention relates to a polypeptide, in particular to a human papilloma virus coat protein L1 short peptide and relative application. The invention is characterized in that the sequence of the human papilloma virus coat protein L1 short peptide is N-EVNLKEKFSADLDQFPLGRKFLLQAGLKAK-C. The invention can simultaneously induce human papilloma virus coat protein L1 short peptide with immunity reaction on high risk type and low risk type, which can induce and form the antibody for various human papilloma virus (HPV) and coat protein (HPV L1), to check various HPV or HPV L1, while the antibody can be used in biological pharmaceutical engineering, to purify and prepare various HPV or HPV L1.

A conveyor system and method that reduces extraneous forces in a manufacturing process is disclosed. The system and method of the invention are particularly directed to handling and processing sensitive materials such as, for example, in clean room manufacturing facilities. These facilities are used in the fields of semiconductor fabrication, hard disk drive manufacturing, biotechnology, biomedical engineering and pharmaceutical engineering. A conveyor system according to the invention includes a carrier and a drive assembly for providing relative movement thereto. A rib or groove extends along the bottom of the carrier parallel to the direction of travel. The rib and groove structures are also intended to reduce mechanical contact between the carrier and the drive assembly, including its components. A reduction of such contact limits the extent of contamination caused by particulate formation.

The invention discloses a two-dimensional multi-shell hollow sphere ordered structure array and a preparation method thereof. The array is a single-layer hollow sphere array orderly and hexagonally arranged on a conductive substrate, wherein the outer diameter of each hollow sphere is between 230 nanometers and 10.7 mu m; the outer surface of each hollow sphere is a rough surface; each hollow sphere consists of a metal gold inner wall and more than two layers of different materials alternatively covered on the metal gold inner wall; and the rough surface consists of particles. The method comprises the following steps of: performing ion sputtering on the conductive substrate on which a single-layer colloidal crystal template is arranged to deposit a gold film; putting the conductive substrate to which a gold film wall is adhered into an electrolyte; electrically depositing under the deposition current density of between -1.0 mA/cm<2> and 1.0 mA/cm<2> for 10 seconds to 3 hours to obtaina single-layer composite array; putting the single-layer composite array into different electrolytes for more than one time; electrically depositing under the same technological condition; and putting the single-layer composite array into a methylene dichloride solvent to remove polystyrene colloidal spheres to obtain a product. The array and the method can be widely applied to the fields of pharmaceutical engineering, cosmetics, biotechnology, photo-catalysis, photonic devices and the like.

The invention relates to new application of interferon-induced transmembrane proteins (IFITMs) in pharmaceutical engineering, in particular to application of IFITM 3 in preparing a medicament for treating diseases related to hepatitis B virus (HBV) infection. Eukaryotic expression vectors of IFITM 1, IFITM2 and the IFITM 3 are respectively constructed by a molecular biological method in a lab; and in vivo-in vitro tests prove that the IFITM 1, the IFITM2 and the IFITM 3 can obviously inhibit HBV replication, wherein, the IFITM 3 has the most remarkable effect. Therefore, the IFITM 3 and an encoding gene thereof are expected to become novel medicaments for treating HBV-related diseases and reducing hazard of HBV-related diseases.

The invention belongs to the field of micro-fluidic chips, and discloses a micro-fluidic chip device for separating bacteria by using laminar flow and chemotaxis effects. The device comprises two parts namely a micro-fluidic chip for separating the bacteria and an inducing reagent concentration control system, wherein the micro-fluidic chip is an approximately 'X'-shaped PDMS-glass chip which is integrated with an inducing reagent inlet, a bacterium inlet, a bacterium separation channel, a bacterium collection outlet and a waste liquid outlet; and the inducing reagent concentration control system consists of a plurality of groups of injection pumps and injectors, parameters such as flow rates and the like can be controlled by virtue of the injection pumps, and thus an inducing reagent of which the concentration dynamically changes with time can be obtained. According to the micro-fluidic chip device disclosed by the invention, operations of separating interested bacteria from a bacterial mixed liquid can be achieved by mainly using the characteristics that the bacteria swim with tendency to high attractant concentration and low repellent concentration directions under the action of laminar flows and chemical inducing reagents. The micro-fluidic chip device disclosed by the invention can be applied to research and analysis of the fields of food safety, water quality monitoring, pharmaceutical engineering, clinical medicines and the like.

The invention belongs to the fields of pharmacology and pharmaceutical engineering and relates to an agomelatine covered pellet and a drug composition capable of being dispersed in the mouth. Concretely, the agomelatine covered pellet comprises an agomelatine main drug and a polyvinylpyrrolidone binding agent. According to the invention, agomelatine covered pellets are hardly adhered, so that pellet coating efficiency is improved and the problem that a spray gun is blocked is avoided; and the agomelatine-containing drug composition capable of being dispersed in the mouth can disintegrate quickly and is good in taste and high in bioavailability. The agomelatine-containing covered pellet and the drug composition capable of being dispersed in the mouth, which are provided by the invention, are easy to prepare, cost is reduced, and the agomelatine-containing covered pellet and the drug composition capable of being dispersed in the mouth are especially applicable to industrial production.

The invention discloses an antibacterial plate. The antibacterial plate is characterized by comprising ABS plate layers, a TPU plate layer and an antibacterial masterbatch layer, the upper surface and the lower surface of the antibacterial masterbatch layer are both connected with the ABS plate layers, the ABS plate layers are connected with the TPU plate layer, and net bars which are crisscrossed are placed inside the antibacterial masterbatch layer; according to the invention, the antibacterial masterbatch layer is arranged, so that the antibacterial plate has an antibacterial property, and then has a certain bactericidal ability to reduce breeding of bacteria so as to protect the health of a human body, and the ABS plate layers and the TPU plate layer are arranged, so that the antibacterial plate is good in static bending strength and anti-deformation ability, and can be applied to building interior wall decoration of hospital operation rooms, pharmaceutical engineering, food processing and the like to reach antibacterial health grades; the antibacterial plate disclosed by the invention does not generate static electricity through arranging an anti-static coating film to effectively prevent accumulation of dust and bacteria caused by dust absorption of electrostatic interaction.

The invention, which belongs to the field of pharmaceutical engineering, particularly relates to a targeted drug delivery system based on milk exosome. The invention discloses a targeted drug deliverysystem based on milk exosome. The construction method comprises: a targeted ligand with an aliphatic chain at one end is modified on the surface of the drug delivery milk exosome, and the other end of the targeted ligand is a molecule capable of being specifically bound with an overexpressed receptor on the surface of a tumor cell. The modified drug delivery milk exosome disclosed by the invention can be bound with cancer cells in a targeting manner, so that the uptake of the cancer cells is enhanced and the effect of specifically killing tumor cells is realized.

The invention specifically relates to a preparation method of a polymer drug carrier-loaded drug, and in particular relates to a composite particle of a polymer embedded hydrophilic antitumor drug prepared through in-situ dispersion polymerization, belonging to the cross technical field chemical engineering, pharmaceutical engineering and material engineering. The hydrophilic antitumor drug is embedded through an in-situ dispersion polymerization technology; a mixed solution of ethanol and de-ionized water serves as a dispersion medium; a monomer, the hydrophilic antitumor drug, an initiator and a dispersant are dissolved in the mixed solution to form a homogeneous solution; and a dispersion polymerization reaction is conducted to obtain the composite particle of the mono-disperse polymer embedded hydrophilic antitumor drug in micrometer size. The method disclosed by the invention, which embeds the drug in the polymer particle through one-step dispersion polymerization, is simple in preparation, and drug molecules are uniformly distributed in the polymer particle; the polymer particle is in micro-sized mono-dispersion; drug loading capacity and encapsulation efficiency of the drug are relatively high; and the preparation method has a broad application prospect in aspect of pharmaceutical preparations.

The invention relates to buccal tablets taking salbutamol sulfate and ambroxol hydrochloride as main active ingredients and a preparation method thereof, and aims to provide a new preparation, namely salbutamol sulfate and ambroxol hydrochloride buccal tablets, for the vast number of patients and medical workers. The preparation has quick response, can improve the bioavailability of medicaments, give full play to the treatment effects of the medicaments and reduce adverse reactions, is convenient for children to swallow and for old people to take with reduced dosage, and is convenient to carry, store and transport. The preparation method is simple and suitable for mass production. In the method, the buccal tablets are prepared by adding some specific types of auxiliary materials in certain proportions into the salbutamol sulfate and ambroxol hydrochloride serving as the active ingredients according to the conventional technique of pharmaceutical engineering.

The invention relates to pills taking salbutamol sulfate and ambroxol hydrochloride as main active ingredients and a preparation method thereof, and aims to provide a new preparation, namely salbutamol sulfate and ambroxol hydrochloride pills, for the vast number of patients and medical workers. The preparation can improve the bioavailability of medicaments, give full play to the treatment effects of the medicaments and reduce adverse reactions, is convenient for children to swallow and for old people to take with reduced dosage, and is convenient to carry, store and transport. The preparation method is simple and suitable for mass production. In the method, the pills are prepared by adding some specific types of auxiliary materials in certain proportions into the salbutamol sulfate and ambroxol hydrochloride serving as the active ingredients according to the conventional technique of pharmaceutical engineering.

The invention belongs to the crossing technical field of chemical engineering, pharmaceutical engineering and material engineering and relates to preparation methods of polymer carried drugs, particularly to a method of preparing a polymer-embedded hydrophobic anti-tumor drug nano-composite microsphere through in-situ miniemulsion polymerization. The method comprises dissolving hydrophobic anti-tumor drugs into acrylate monomers, and then adding the mixture slowly into water solution containing emulsifier; performing ultrasonic emulsification on the mixed water solution through an ultrasonic cell crusher to obtain miniemulsion, and then performing in-situ miniemulsion polymerization to obtain the embedded hydrophobic anti-tumor drug nano-composite microsphere. According to the preparation method of the polymer-embedded hydrophobic anti-tumor drug nano-composite microsphere, the hydrophobic anti-tumor drug is embedded through a single polymerization step, so that drug molecules can be distributed evenly, and meanwhile, high drug carrying capacity and high encapsulating rate can be obtained; no organic solvent is utilized during the reactions, so that environmental pollution and secondary damage to human can be avoided. The method of preparing the polymer-embedded hydrophobic anti-tumor drug nano-composite microsphere has a wide application prospect.

The invention relates to the technical field of chemical and pharmaceutical engineering and in particular to a multifunctional continuous flow reaction system. The multifunctional continuous flow reaction system comprises multistage feeding devices, multistage mixing devices, multistage preheating devices, multistage reaction devices, a quenching device, a CIP cleaning device and a blowing and drying device. Reaction tubes in the reaction devices successively communicate through communicating devices, and the feeding devices, the mixing devices, the preheating devices, the reaction devices, the quenching device, the CIP cleaning device and the blowing and drying device are controlled by means of software and a universal hardware platform according to concentration proportion of raw materials needed by chemical reactions and corresponding reaction conditions. The multifunctional continuous flow reaction system provided by the invention is good in mixing effect, precise to control the reaction conditions, uniform in heat transfer and mixing, relatively small in size and occupied space and low in production cost, can continuously realize multistage chemical reactions, and can efficiently master reactant residues in the reaction system and keep the reaction system clean inside.

The invention relates to the field of pharmaceutical engineering and discloses a method for preparing oxaliplatin. The method comprises the following steps of: reacting aqueous solution of cis-((1R,2R)-(-)-1,2-diaminocyclohexaneplatinum)dichloride with silver nitrate under the shading and heating conditions; filtering and adding the excessive saturated solution of sodium chloride into the filtrate for reaction and filtering; adding ammonia water and sodium oxalate into the filtrate and reacting under the heating condition; and concentrating and crystallizing to obtain a crystal, and purifyingthe crystal by using activated carbon, wherein the molar ratio of the cis-((1R,2R)-(-)-1,2-diaminocyclohexaneplatinum)dichloride to the silver nitrate is 1:2-2.5, and the molar ratio of the cis-((1R,2R)-(-)-1,2-diaminocyclohexaneplatinum)dichloride to the sodium oxalate is 1:1-2. The method for preparing the oxaliplatin of the invention has a high yield, and the oxaliplatin product prepared by the method has the advantages of no chiral enantiomer, a little residual silver, high purity and suitability for industrial production when used as a chemical raw material medicament.

The invention belongs to the field of chemical and pharmaceutical engineering, and relates to a method for extracting hesperidin from navel orange fruits and navel orange peels. A lot of navel orange fruits and navel orange peels are abandoned, so that resource is waste. The method is used for extracting hesperidin from navel orange fruits and navel orange peels, which comprises the following steps: The method comprises the following steps: 1) drying and grinding; 2) Soxhlet extraction; 3) rotary evaporation; 4) suction filtration and extraction of crude hesperidin; 5) column chromatography isolation; and 6) extraction of fine hesperidin. The method has the advantages that 1) navel orange fruits and navel orange peels are comprehensively used and the valuable components are recovered, resource waste is reduced, resource utilization rate is increased; 2) the hesperidin recovery rate is high, crude hesperidin recovery rate is 89.3%, and the fine hesperidin recovery rate is 93.6%; and 3) by recovering the hesperidin in the navel orange fruits and navel orange peels, economic benefit of the navel orange industry is increased.

The invention belongs to the technical field of pharmaceutical engineering, and particularly relates to a micro-reaction system and a method for continuously preparing 2-methyl-4-amino-5-aminomethylpyrimidine by using the micro-reaction system. The method comprises the following steps: modifying a Raney nickel catalyst by using formalin, filling a micro-channel reactor with the modified Raney nickel catalyst; simultaneously conveying hydrogen and a substrate solution containing both 2-methyl-4-amino-5-cyanopyrimidine and an alkaline agent into the micro-reaction system comprising a micro-mixerand the micro-channel reactor which communicate with each other in sequence; and carrying out a continuous catalytic hydrogenation reaction to obtain the 2-methyl-4-amino-5-aminomethylpyrimidine. Compared with the prior art, the method provided by the invention has the advantages that reaction time is only several minutes, the yield of the product 2-methyl-4-amino-5-aminomethylpyrimidine is greater than 99%, a technological process is continuous, an automation degree is high, space-time yield is high, operation is simple and convenient, the separation steps of reaction liquid and a catalyst is not needed, cost is low, and industrial production is easy.

The invention relates to the technical field of biological pharmacy, and discloses a dynamic extraction tank for biopharmaceutical engineering. The dynamic extraction tank comprises an outer tank andan inner tank, the inner tank is fixedly arranged in the inner cavity of the outer tank, a vacuum cavity is arranged between the outer tank and the inner tank, and the outer wall of the inner tank isrespectively provided with an upper wire coil and a lower wire coil which are positioned at two ends. Through the acting force of the upper wire coil and the lower wire coil on a driving mechanism, the driving mechanism can drive a pressing plate to rotate up and down, so that the effect of stirring an extracting solution and a material is achieved, the material is always located below the pressing plate, the pressing plate is prevented from stalling, and even if the pressing plate stalls, due to the fact that electromagnetic force is soft force, the driving mechanism can rotate in a directionto a certain degree, damage to the driving mechanism is avoided, meanwhile, the effect of gently extruding materials can be achieved, the rate of dissolving effective components of the materials in the extracting solution is increased on the premise that fine crushing of the materials is reduced as much as possible, and the extraction efficiency is improved.

The invention discloses an ABS composite board, which is characterized by comprising an ABS board layer and a sound-absorbing layer. Upper and lower surfaces of the sound-absorbing layer are both connected to the inner surface of the ABS board layer. The outer surface of the ABS board layer is compounded with an ASA material layer. With the arrangement of the ASA material layer, the ABS composite board has weatherability and impact resistance, and can be used outdoors. With the arrangement of the sound-absorbing layer, rigidness of the board can be enhanced, and good sound absorption and sound insulation can be provided. With the arrangement of antibacterial masterbatch, the ABS composite board has an antibacterial property. The board has a certain bactericidal ability. Thus, bacteria growth is reduced, and body health is protected. The ABS composite board can be applied to operation rooms in hospitals, pharmaceutical engineering and food processing, etc. Building interior wall decoration reaches the antibacterial hygienic level.