32 results about "Pharmaceutical engineering" patented technology

The invention relates to the technical field of traditional Chinese medicine pharmaceutical engineering, and particularly discloses a traditional Chinese medicine extraction and concentration intelligent control system and method based on multi-modal sensing and deep reinforcement learning. The system comprises a multi-modal sensing layer, an edge computing gateway, an intelligent decision-making layer and an expert knowledge base; the edge computing gateway inputs the multi-dimensional time sequence data of the 30-second window into a mixed time sequence prediction model composed of a TCN and double LSTMs, and outputs a sudden boiling risk probability; when the sudden boiling risk probability is lower than a threshold value, an intelligent decision-making layer adopts combined control to generate a fine control quantity, when the sudden boiling risk probability is greater than or equal to 0.95, sudden boiling emergency interlocking is triggered, a main steam valve is closed within 0.5 second, and a vacuum buffer tank is linked to reduce the pressure in the kettle to a safe vacuum zone; and the expert knowledge base applies temperature and vacuum safety constraints to the deep reinforcement learning reward function to ensure that the control action does not cross the medicinal material safety boundary, and automatic control with safe and stable whole process and determinable end point is realized.

The invention relates to the field of pharmaceutical engineering and automatic control, in particular to a reaction kettle for synthesizing a medical intermediate and an intelligent control method of the reaction kettle. The reaction kettle comprises a reaction kettle main body, a stirring assembly integrated with a dynamic torque sensor and a thermotechnical pipeline assembly, the system firstly executes no-load calibration to draw a mechanical friction loss curve and a heat transfer coefficient map; deducting friction reference inversion apparent viscosity by using real-time torque during operation, and judging a reaction stage in combination with a reaction heat rate; then dynamic heat balance control is executed, and a medium temperature change compensation strategy or a rotating speed shearing strategy is selected to be executed according to the heat transfer deviation; the method is characterized in that high-precision viscosity inversion is achieved by eliminating mechanical friction interference, the polymerization degree or the crystallization state is visually monitored on the premise that the closed environment is not damaged, and the problem that the reaction process is invisible in the prior art is solved.

This utility model discloses a pulping device for preparing earthworm extract, relating to the field of pharmaceutical engineering. It includes a tank, with connecting boxes fixedly connected to both sides of the tank. An electric push rod is installed inside the connecting boxes, and a moving block is fixedly connected to the upper end of the electric push rod. Slider blocks are fixedly connected to both sides of the moving block, and ball bearings are installed inside the sliders. A connecting rod is fixedly connected to the upper end of the sliders. The advantages of this utility model are: the electric push rod, moving block, slider, scraper ring, and sliding rod enable the scraper ring to circulate and reciprocate within the tank, thereby promptly scraping away the earthworm raw material adhering to the inner wall, ensuring it returns to the pulping area for further pulverization, and improving the uniformity of pulping; the short rod, retaining ring, spring, limiting rod, and short block enable quick loading and unloading of the filter plate, facilitating maintenance during long-term use and reducing maintenance difficulty.

This utility model discloses a low-temperature concentration device for a traditional Chinese medicine probiotic hangover remedy, belonging to the field of pharmaceutical engineering technology. The key technical features include a horizontal concentration tank with end caps bolted to both sides. A reciprocating mixing mechanism is movably connected to the inner side of the horizontal concentration tank, and a flow guiding mechanism is movably connected to the outer side of the reciprocating mixing mechanism. The main shaft can be driven to rotate in both directions by servo motors on both sides, breaking the regular vortex formed by unidirectional stirring within the horizontal concentration tank. This irregular mixing promotes the flow of the liquid and heat and mass transfer, suppressing local temperature differences and sedimentation. It ensures the stability of heat-sensitive components and enhances the homogenization of the solid and liquid phases through dynamic switching of the rotation direction. This effectively solves the problems of regular vortex formation, low mixing efficiency, and insufficient uniformity caused by unidirectional stirring in traditional low-temperature concentration devices, achieving a dual improvement in concentration efficiency and product quality.

The utility model relates to the field of traditional chinese medicine pharmaceutical engineering discloses a kind of traditional chinese medicine decoction pieces drying sterilization box, including drying cabinet, dust screen is fixedly connected in the upper and lower sides of drying cabinet, fan is fixedly connected in the top middle of drying cabinet, telescopic slide is fixedly connected in the inside bottom of drying cabinet, bracket is fixedly connected in the top of telescopic slide, support block is fixedly connected in the bottom of bracket, a plurality of drying nets are fixedly connected in the inboard of bracket, electric push rod is fixedly connected in the rear side of drying cabinet, push rod is fixedly connected in the output end of electric push rod. In the utility model, by driving electric push rod to push push rod to move forward, push rod will drive bracket to move forward, in turn make the telescopic slide of the bottom of bracket will be stretched out and unfolded forward, until electric push lever will entire bracket be pushed out the inside of drying cabinet, it is realized that user need not reach hand into box body and can be taken or medicinal material is placed on drying net.

The application discloses a preparation method of 3-ketotetrahydrofuran and belongs to the technical field of biological catalysis and pharmaceutical engineering. The application aims to provide an enzymatic oxidation reaction method for obtaining 3-ketotetrahydrofuran with high conversion rate and high yield. In the application, alcohol dehydrogenase mutants are used to catalyze the oxidation of chiral 3-hydroxytetrahydrofuran in a whole cell and a pure enzyme, so that the biosynthesis of 3-ketotetrahydrofuran is realized, the highest yield is 29.73%, and the selectivity is 95.3%. The method has the advantages of mild conditions, environmental friendliness and low cost, and has high application potential.

This application provides a cationic lipid nanovaccine adjuvant and its preparation method, which can be applied to the field of pharmaceutical formulation in pharmaceutical engineering. The method includes: dissolving polylactic acid materials and cationic surfactants in an organic solvent, and ultrasonically mixing them to obtain an oil phase; using ultrapure water as the aqueous phase, uniformly adding the oil phase to the aqueous phase under stirring at a predetermined speed, and continuously stirring until an oil-in-water emulsion is formed; solidifying the oil-in-water emulsion by vacuum evaporation for 3-6 hours at 10-70℃ and -0.01-0.8 Pa to obtain a cationic lipid nanosphere suspension; and circulating and washing the cationic lipid nanosphere suspension with a tangential flow ultrafiltration membrane with a molecular weight cutoff of 100 kDa to obtain the cationic lipid nanovaccine adjuvant.

This invention discloses a powder mixing pharmaceutical device for pharmaceutical engineering, comprising a cylindrical drum, a fixed plate fixedly connected to the top of the drum, an openable cover hinged to the outer wall of the fixed plate, a motor fixedly connected to the top of the fixed plate, a connecting rod fixedly connected to the output end of the motor, and a mixing mechanism provided on the outer wall of the connecting rod. This relates to the field of pharmaceutical technology. By setting up the mixing mechanism, the bearing disc B rotates on the outer wall of the annular sleeve, causing the spring to deform. Simultaneously, the rotation of the threaded rod and the bearing disc B causes the threaded rod and the bearing disc B to rotate synchronously. Furthermore, the bristles on the outer wall of the stirring rod are agitated by the rotating threaded rod, causing the bristles to rebound due to their own elasticity, rapidly agitating the powder and improving the powder mixing efficiency. The rapid rebound of the bristles also disperses any clumps of powder adhering to the bristles, preventing adhesion from affecting the mixing effect.

The utility model discloses an extrusion forming device, and particularly relates to the technical field of pharmaceutical engineering, the extrusion forming device comprises a bottom assembly, a middle assembly is arranged at the top of the bottom assembly, and a feeding assembly is arranged at the top of the middle assembly; the feeding assembly comprises a motor, the output end of the bottom of the motor is fixedly connected with a rotating gear, the two sides of the rotating gear are engaged with racks, one ends of the racks are fixedly connected with fixing strips, the sides, away from the racks, of the fixing strips are fixedly connected with pushing blocks, the bottoms of the pushing blocks are fixedly connected with a plurality of T-shaped sliding blocks, and inner cavities of the pushing blocks are provided with material storage cavities. A plurality of bevel guide blocks are fixedly connected to the bottom of an inner cavity of the storage cavity, a second lifting base is arranged on the side, away from the motor, of the pushing block, a plurality of upper extrusion columns are fixedly connected to the bottom of the second lifting base, connecting sleeve columns are fixedly connected to the two sides of the second lifting base, and screw rod columns are rotationally connected to inner cavities of the connecting sleeve columns; the bottoms of the lead screw columns are rotationally connected with lead screw lifting machine bodies. The yield is improved, and consumables are reduced.

The invention belongs to the technical field of pharmaceutical engineering and medical technology, and discloses a medicine dispensing method for realizing diversified preparation of medicines, which comprises the following steps: acquiring prescription information of a patient, determining physical morphological characteristics and chemical stability characteristics of the medicines, and determining individualized adjustment factors of the medicines; generating a dispensing sequence table according to the individualized adjustment factors and the physical morphological characteristics; based on the dispensing sequence table and the chemical stability characteristics, determining an isolation demand level, and distributing a dispensing operation interval according to the isolation demand level; determining a dose segmentation mode of each medicine, and performing dose segmentation on each medicine according to the dose segmentation mode; performing dynamic compatibility verification on the dose segmentation results, and after the verification is passed, combining and packaging all the dose segmentation results so as to obtain a customized medicine combination of the patient; and a technical support is provided for implementation of a precise medical idea in medicine service.

The utility model discloses a medicine material concentration sandwiched layer pot relates to pharmaceutical engineering equipment technical field, and its technical scheme main points are including machine table, the rotatory setting of machine table has the pot body, and the upper mouth of pot body is fixed with the support plate, is provided with motor box on the support plate, and the bottom of motor box is provided with the output shaft, and the telescopic axle rod subassembly is installed to the output shaft bottom, and the both ends of axle rod subassembly are provided with the folding stirring unit, and the axle rod subassembly contracts the stirring unit folding through contraction control, be provided with the trigger component that drives axle rod subassembly telescopic on the machine table, make the pot body when carrying out the shrinkage action of synchronous trigger axle rod subassembly of dumping action. The utility model discloses through being provided with the movable folding stirring unit, cooperate the telescopic axle rod subassembly and trigger component, make the pot body when carrying out dumping medicine, and the stirring unit can synchronous folding, and then expand the clearance of stirring unit and the inner wall of pot body, guarantee that high viscosity medicine can flow smoothly pour, reduce the medicine residue, reduce production cost.

The invention relates to the technical field of pharmaceutical engineering, in particular to a pharmaceutical grade sodium thiosulfate preparation device and a preparation method thereof.The pharmaceutical grade sodium thiosulfate preparation device comprises a frame body, a mixing tank, a plurality of supporting legs and a stirring mechanism, the supporting legs are arranged on the frame body and located at the bottom of the frame body, and the mixing tank is installed on the frame body; the stirring mechanism comprises a double-shaft motor, a transmission assembly, a supporting shaft, a connecting shaft, a stirring rod, a lifting assembly and a sliding part, the supporting shaft is rotatably connected with the frame body, the frame body is provided with a sliding groove, the sliding part is slidably connected with the sliding groove, the connecting shaft is rotatably connected with the sliding part, the stirring rod is fixedly connected with the connecting shaft, and the connecting shaft is slidably connected with the supporting shaft; the double-shaft motor is mounted on the frame body, so that the technical problems that in the prior art, most sodium thiosulfate preparation devices are based on traditional chemical reaction kettles, so that reaction materials are mixed unevenly, local reaction is insufficient, and the purity and yield of final products are affected are solved.

The utility model relates to the technical field of pharmaceutical engineering discloses a tablet press for tablet production, including work table, the top fixedly connected with support of work table, the top inboard fixedly connected with electric telescopic handle of support, the top inwall fixedly connected with hydraulic pressure rod of work table, the bottom of electric telescopic handle is provided with adjusting mechanism, the adjusting mechanism includes the fixed frame fixedly connected in the bottom of electric telescopic handle, and the bottom outer wall fixedly connected with fixed plate of fixed frame, the inwall rotationally connected with rotating column of fixed plate, the outer wall fixedly connected with punch die of connecting plate, the right side of fixed plate is provided with indicating piece, in the utility model, when needing to replace different specifications punch die and its punch box, then the bolt position is released, and then rotating rotating column makes punch die and its punch box rotate, thereby the specification is replaced, and the overall work efficiency is improved.

The utility model relates to the technical field of pharmaceutical engineering, and discloses a Chinese herbal medicine component separation and concentration device structure which comprises an extraction tank, a feeding box is fixedly connected to the upper surface of the extraction tank, an opening and closing assembly is fixedly connected to the outer wall of the feeding box, and a hinge is fixedly connected to the outer wall of the extraction tank. A bottom cover is fixedly connected to the outer wall of a hinge, an air cylinder is rotatably connected to the outer wall of the extraction tank, a supporting rod is connected to the output end of the air cylinder, a conveying pipe is fixedly connected to the interior of the extraction tank, a concentration tank is fixedly connected to the outer wall of the conveying pipe, and a steam valve is fixedly connected to the interior of the extraction tank. And a solvent valve is fixedly connected to the interior of the extraction tank. According to the feeding device, the second motor is started to drive the first connecting rod, so that the second connecting rod is driven, the third fixing rod and the third connecting rod are further driven, and the feeding cover is further opened, so that the effects of improving the feeding efficiency and further improving the efficiency of the whole production process can be achieved.

This invention provides an oral liquid preparation data monitoring system based on diaphragm valve feedback signals, belonging to the field of pharmaceutical engineering technology. The method includes: collecting feedback signals from multiple diaphragm valves during the oral liquid preparation process, including valve core switch status signals, downstream pressure feedback signals, and flow sensor linkage signals; preprocessing the feedback signals by signal filtering and error correction to obtain preprocessed stable signal data; dynamically determining detection nodes at the diaphragm valve outlet end in the inner wall region of the delivery pipe based on the preprocessed stable signal data; obtaining dynamic geometric figures based on the spatial coordinates of the detection nodes; and calculating the instantaneous flow rate and cumulative delivery volume of the material delivery pipeline based on the dynamic geometric figures to obtain an instantaneous flow rate data stream. This invention can solve the problems of low accuracy, slow response, and reliance on manual labor in existing technologies, and improve the intelligence and reliability of the oral liquid preparation process.

1. Name of the product in this design: Centrifuge (Pharmaceutical Engineering). 2. Application of this design: This design is used for the separation of pharmaceutical materials. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention provides a Shenfu injection alcohol solution pH overshoot control method, device and equipment and a storage medium, and relates to the technical field of traditional Chinese medicine pharmaceutical engineering. The control method comprises the following steps: acquiring an initial volume of a to-be-adjusted liquid medicine and calculating a predicted total alkali amount; adding first-stage alkali liquor until a preset inflection point proportion is reached; adding of the alkali liquor is stopped, and the real-time pH value is measured; if the real-time pH value is within the inflection point pH range, marking the current accumulated alkali adding amount as the actual inflection point alkali adding amount, and calculating the residual required alkali adding amount; and adding the residual required alkali into the to-be-adjusted liquid medicine. According to the invention, model prediction is combined with segmented control, and intermittent cleaning measurement is utilized to thoroughly solve the problem of detection misalignment caused by precipitation interference on the electrode. Meanwhile, based on a dynamic calibration mechanism of inflection point actual measurement data, control deviation of a nonlinear system is effectively overcome, accurate locking of a pH end point is achieved, effective components are prevented from being decomposed due to overshoot, and production efficiency and medicine quality are remarkably improved.

The utility model relates to the technical field of pharmaceutical engineering, and discloses an aminoglycoside antibiotic separation and purification device which comprises a filtering device, a separation device is arranged on the outer wall of the filtering device, a fixing frame is fixedly connected to the outer wall of the separation device, an alcohol lamp is arranged in the fixing frame, a safety bottle is arranged in the fixing frame, and the safety bottle is connected with the filtering device. A fixing rod is fixedly connected to the top of the fixing frame, a support is arranged on the outer wall of the fixing rod, a purification assembly is arranged in the support, a clamping assembly is arranged in the fixing frame, and the clamping assembly comprises a clamping block. According to the utility model, the clamping blocks are extruded by the alcohol lamp and the safety bottle, and the spring I moves towards the interior of the hollow column through the extrusion of the clamping blocks, so that the effect of clamping the alcohol lamp and the safety bottle is achieved, and the problem that the alcohol lamp and the safety bottle are separated from the original positions due to vibration or touch in the use process is solved; the problems that the alcohol lamp is broken and the purification effect is invalid are solved, and the safety is improved.

The invention relates to the technical field of pharmaceutical engineering and processes, and particularly discloses a preparation process of a blonanserin quick-release tablet capable of masking mouth feel. Comprising the following steps: S1, grinding a blonanserin raw material, a pH dependent polymer and citric acid; s2, performing hot-melt extrusion on the composite active powder and the molten polyhydric alcohol solid dispersion carrier; s3, mixing the drug-loaded solid dispersion particles with a quick release disintegrating agent and a part of filler by a dry method; s4, co-dissolving the saliva trigger soluble polymer and the pore regulator in a solvent; s5, adopting electrostatic coating; s6, mixing the coated particles with the residual filling agent, disintegrating agent and lubricating agent; and S7, tabletting. The preparation process of the blonanserin quick-release tablet can be used for solving the problem that a schizophrenia patient feels bitter and astringent in taste and difficult to take effect at the same time in the long-term medicine taking process, and the blonanserin quick-release tablet has the advantages of reliable taste masking effect, quick in-stomach release and stable and controllable production process.

The utility model relates to the technical field of pharmaceutical engineering, disclose goose deoxycholic acid crystallization integrated device, including crystallization kettle, the upper surface of crystallization kettle is connected with the crystallization kettle cover plate slidingly, the inner wall of crystallization kettle cover plate is fixedly connected with telescopic water pipe, the upper surface of crystallization kettle cover plate is fixedly connected with flange shaft sleeve, the upper surface of flange shaft sleeve is fixedly connected with connecting plate, the upper surface of connecting plate is fixedly connected with motor, the output of motor is fixedly connected with bearing, the lower surface of bearing is fixedly connected with shaft body, the output of motor is fixedly connected with paddle, the inside of crystallization kettle is provided with cleaning mechanism, in the utility model, through telescopic pipe spherical shower nozzle, telescopic rod is used as water inlet valve connection shower nozzle part, can directly to the bottom of device work, the spherical shower nozzle can be without dead angle spray in the crystallization kettle inner wall cleaning fluid, and the problem of not easy to clean is improved.

The invention discloses a preparation flow control system of a traditional Chinese medicine nano-liposome preparation, and relates to the technical field of automatic control and pharmaceutical engineering, and the system comprises a comprehensive control platform which is in communication connection with the following modules: a multi-source data acquisition module, a multi-source data processing module and a multi-source data processing module, the method is used for collecting multi-source data including quality attributes and process parameters in the preparation process of the traditional Chinese medicine nano-liposome preparation in real time. According to the preparation process control system of the traditional Chinese medicine nano-liposome preparation, the preparation process of the traditional Chinese medicine nano-liposome preparation is monitored and optimized in real time through combination of a digital twin technology and an ant colony algorithm, a process adjustment scheme can be quickly generated and verified when it is predicted that the encapsulation efficiency is lower than a threshold value, and it is ensured that the production process is always in an optimal state; by means of the method, production stagnation and rework caused by quality problems are greatly reduced, production efficiency is remarkably improved, and meanwhile the yield and consistency of production are improved by accurately controlling technological parameters.

This invention discloses a pharmaceutical tablet powder mixing machine for pharmaceutical engineering, relating to the field of pharmaceutical processing technology. The pharmaceutical tablet powder mixing machine includes a machine body, with rotating components rotatably connected to both sides of the front of the machine body. A tank is fixedly connected between two of the rotating components, and a discharge mechanism is provided inside the tank. The discharge mechanism includes two limiting plates, which are respectively fixedly connected to the two side walls of the inner cavity of the tank. A sliding circular plate is provided inside the tank. Through the design of the discharge mechanism, after the pharmaceutical tablet powder inside the tank is completely mixed, the sliding circular plate can also scrape and separate the tablet powder during the discharge process, ensuring more thorough collection of the tablet powder and preventing impurities from occurring during subsequent mixing due to differences in the tablet powder.

The present application belongs to the field of essence and fragrance and pharmaceutical engineering, and relates to a method for preparing muscone. 4-methylcyclopentadecanone is placed in a solvent with sulfur and a secondary amine under an inert atmosphere, heated to 64-120 DEG C, and reacted for 12-42 hours to obtain muscone; wherein the secondary amine is an organic compound containing a secondary amine group. The present application can convert the by-product 4-methylcyclopentadecanone into 3-methylcyclopentadecanone, i.e. convert the muscone by-product into muscone, which not only enables high-value utilization of the muscone by-product, but also reduces the cost in the production process of muscone.

The utility model belongs to the technical field of pharmaceutical engineering, and particularly discloses a hot air filtering device for medicine production, which comprises a tank body, an air inlet is arranged on the side edge of the tank body, a heating box is fixed outside the air inlet, a heating pipe is arranged inside the heating box, and one side of the heating box far away from the tank body is connected with a filtering box. A mounting slot is formed in the upper part of the filter box, a connecting port is formed in the filter box, a screen frame is inserted into the mounting slot, a filter screen is arranged in the screen frame, a positioning slot is formed in the side edge of the screen frame, and the filter box is connected with an external fan by arranging the connecting port; a movable cylinder is arranged on the side edge of the filter box, a movable block is slidably connected into the movable cylinder, a connecting rod and a positioning insertion block are fixed to the two ends of the movable block respectively, and the positioning insertion block is inserted into the positioning insertion groove to fix the screen frame; the screen frame is fixed through the positioning insertion blocks, and when the screen frame needs to be dismantled to maintain the filter screen, only the positioning insertion blocks need to be pulled out of the positioning insertion grooves, and the screen frame can be pulled out of the filter box after the positioning insertion blocks are pulled out.

The invention belongs to the technical field of pharmaceutical engineering, and particularly provides a preparation method of virus-like particles composed of truncated protein. The truncated protein is a norovirus target antigen truncated body, and the method comprises the following steps: (1) taking a host thallus for expressing a norovirus target antigen, and repeatedly freezing and thawing the host thallus; (2) suspending the frozen and thawed thalli in a buffer solution, and performing high-pressure homogenate crushing on the thalli until the crushing rate of the thalli is greater than or equal to 80% to obtain homogenate; carrying out crude purification on the homogenate to obtain a crude purified supernatant; and (3) standing the crude pure supernate under a certain condition, and then finely purifying to obtain the virus-like particles formed by the truncated protein. The method can be used for preparing sufficient and high-purity truncated protein at one time, and has important significance on quality research of broad-spectrum virus antigen vaccines.

The invention discloses an injection water preparation device and a pharmaceutical device, and belongs to the technical field of pharmaceutical engineering and pure water treatment. The device comprises a rotary distillation shaft, a spiral guide groove, a guide sliding block, a connecting ring, a transmission rod, a distillation plate, a sliding valve plate, a sealing valve plate, a steam conveying pipe, a liquid medicine conveying pipe, a heating partition plate, a condensation shell, a condensation plate, a steam collecting pipe, a condensation tank, a preheating tank, a liquid collecting plate, a filter plate, a water storage tank and the like. The rotary distillation shaft rotates to drive the guide sliding block to reciprocate along the spiral guide groove, linkage control over the distillation plate and the sliding valve plate is achieved, steam and liquid medicine conveying is alternately switched on and off, and efficient distillation and condensation are achieved. The device integrates the functions of preheating, distilling, condensing, filtering and collecting, has the advantages of compact structure, low energy consumption, stable water quality, high operation automation degree and the like, and is suitable for preparation of continuous injection water and liquid treatment links in a pharmaceutical process.

The invention discloses a method for preparing clinical medicinal grade iodine 131 by separating medical radioactive waste, and relates to the technical field of pharmaceutical engineering, the clinical medicinal grade iodine 131 is prepared by pre-treating the used molybdenum-technetium generator medical radioactive waste liquid through selective precipitation, microorganism-electrochemical catalytic reduction, oxidative distillation, chromatographic refining and degerming filtration blending. The method has the advantages that the purity and the yield of the iodine 131 separated from the medical waste liquid are remarkably improved by establishing a set of multi-stage synergistic purification process comprising pretreatment, selective precipitation, microorganism-electrochemical catalytic reduction, oxidative distillation and chromatographic refining; wherein filtration acidification and carrier addition in the pretreatment stage effectively guarantee the stability of an initial material, and subsequent precipitation and reduction operations deeply remove isotope impurities such as technetium and molybdenum and radioactive interference nuclides, so that the problems of low product purity and high impurity residue caused by single purification step in the traditional process are thoroughly solved.

The invention belongs to the technical field of food and pharmaceutical engineering, and relates to a high-embedding-rate astaxanthin nano-emulsion microjet homogeneous circulation treatment method and system. The method comprises the following steps: firstly, constructing a mixed system of an astaxanthin oil phase and a compound emulsifier water phase, and preparing an initial coarse emulsion; then the pumping system executes a first round of high-pressure homogenization to output primary circulation emulsion; collecting microscopic physical field data by using a rheological sensing unit to generate a rheological state feature vector; analyzing the vector to determine the rigid state of an interfacial film, and matching a strategy to generate an energy regulation and control instruction; controlling an energy field generator to selectively operate the reflux emulsion to generate a pretreatment fluid; the fluid is driven to execute secondary shear dispersion and cooling through the homogenizing cavity, the particle size convergence degree is monitored, and circulation termination or circulation continuing is judged according to a threshold value. The problems that the energy utilization efficiency is low and active ingredients have degradation risks due to the fact that an existing homogenizing process adopts a fixed parameter mode and lacks feedback regulation and control on the real-time state of the emulsion are solved.

This application provides a method for early warning and control of microbial contamination in eye drop production, applied in the fields of pharmaceutical engineering and automation control technology. The method includes: collecting droplet sequences from filling needles, extracting necking time deviation, abnormal interface oscillation amplitude, and detachment volume deviation, and encapsulating these as abnormal physical indicators; collecting differential impedance of the high-purity water pipeline wall, the ratio of low-frequency response of adherent particles, and fluid pulsation attenuation to construct a biofilm formation risk index; merging these two data points in time to generate a current contamination risk score; combining wind speed disturbances, pressure differential jumps, and personnel trajectories, locating the contamination source and predicting the microbial diffusion path through reverse flow field tracing and forward simulation; and generating a comprehensive early warning score through spatiotemporal fusion, triggering tiered dynamic control measures such as maintaining production, issuing early warnings, suspending filling, flushing pipelines, regional lockdown, or adjusting airflow. This invention achieves real-time perception, precise source tracing, and proactive prevention and control of microbial contamination.