54 results about "Pharmaceutical engineering" patented technology

The utility model relates to the technical field of pharmaceutical engineering, and discloses a crushing and extracting mechanism for separating traditional Chinese medicine components, which comprises a base, an immersion barrel and a crushing box are assembled at the top of the base, a discharge port is assembled between the immersion barrel and the crushing box, a feed port is arranged at the top of the crushing box, and a discharge port is arranged at the bottom of the crushing box. A screening assembly and a grinding assembly are arranged in the smashing box, a temperature control assembly is arranged on the outer side of the immersion barrel, a liquid inlet pipe is assembled on the top of the immersion barrel, a liquid outlet pipe is assembled at the bottom of the immersion barrel, the screening assembly comprises a first motor, and the first motor is assembled in the middle of the smashing box. According to the utility model, under the cooperation of the motor I, the eccentric block, the screen, the spring rod and other structures, impurities are effectively prevented from being mixed into the leaching liquor, the subsequent purification process is smoothly and efficiently carried out, the purity of the leaching liquor is powerfully guaranteed, and a foundation is built for the output of high-quality traditional Chinese medicine components.

The invention relates to the technical field of traditional Chinese medicine pharmaceutical engineering, and particularly discloses a traditional Chinese medicine extraction and concentration intelligent control system and method based on multi-modal sensing and deep reinforcement learning. The system comprises a multi-modal sensing layer, an edge computing gateway, an intelligent decision-making layer and an expert knowledge base; the edge computing gateway inputs the multi-dimensional time sequence data of the 30-second window into a mixed time sequence prediction model composed of a TCN and double LSTMs, and outputs a sudden boiling risk probability; when the sudden boiling risk probability is lower than a threshold value, an intelligent decision-making layer adopts combined control to generate a fine control quantity, when the sudden boiling risk probability is greater than or equal to 0.95, sudden boiling emergency interlocking is triggered, a main steam valve is closed within 0.5 second, and a vacuum buffer tank is linked to reduce the pressure in the kettle to a safe vacuum zone; and the expert knowledge base applies temperature and vacuum safety constraints to the deep reinforcement learning reward function to ensure that the control action does not cross the medicinal material safety boundary, and automatic control with safe and stable whole process and determinable end point is realized.

The invention relates to the field of pharmaceutical engineering and automatic control, in particular to a reaction kettle for synthesizing a medical intermediate and an intelligent control method of the reaction kettle. The reaction kettle comprises a reaction kettle main body, a stirring assembly integrated with a dynamic torque sensor and a thermotechnical pipeline assembly, the system firstly executes no-load calibration to draw a mechanical friction loss curve and a heat transfer coefficient map; deducting friction reference inversion apparent viscosity by using real-time torque during operation, and judging a reaction stage in combination with a reaction heat rate; then dynamic heat balance control is executed, and a medium temperature change compensation strategy or a rotating speed shearing strategy is selected to be executed according to the heat transfer deviation; the method is characterized in that high-precision viscosity inversion is achieved by eliminating mechanical friction interference, the polymerization degree or the crystallization state is visually monitored on the premise that the closed environment is not damaged, and the problem that the reaction process is invisible in the prior art is solved.

This utility model discloses a pulping device for preparing earthworm extract, relating to the field of pharmaceutical engineering. It includes a tank, with connecting boxes fixedly connected to both sides of the tank. An electric push rod is installed inside the connecting boxes, and a moving block is fixedly connected to the upper end of the electric push rod. Slider blocks are fixedly connected to both sides of the moving block, and ball bearings are installed inside the sliders. A connecting rod is fixedly connected to the upper end of the sliders. The advantages of this utility model are: the electric push rod, moving block, slider, scraper ring, and sliding rod enable the scraper ring to circulate and reciprocate within the tank, thereby promptly scraping away the earthworm raw material adhering to the inner wall, ensuring it returns to the pulping area for further pulverization, and improving the uniformity of pulping; the short rod, retaining ring, spring, limiting rod, and short block enable quick loading and unloading of the filter plate, facilitating maintenance during long-term use and reducing maintenance difficulty.

The invention relates to a decontamination method, in particular for use in pharmaceutical engineering, characterized by the following method steps: introducing a decontamination agent into at least one gas line (07) for supplying at least one atomizer (04) with a carrier gas flow, preferably compressed air; the atomizer is arranged in the isolation space (02) and is preferably realized as a two-fluid nozzle; the at least one atomizer (04) is supplied with a decontaminating liquid, preferably hydrogen peroxide, by a decontaminating agent storage container (06) via a valve device controlled by an electronic control device in order to generate a decontaminating aerosol during a decontaminating operation of the isolated space (02); the at least one atomizer (04) is connected in a gas-conducting manner to a gas pressure source (08) via the gas line (07), and a filter (11) for filtering the carrier gas flow is arranged in the gas line (07) between the gas pressure source (08) and the atomizer (04), preferably separately configured for each atomizer (04).

This utility model discloses a low-temperature concentration device for a traditional Chinese medicine probiotic hangover remedy, belonging to the field of pharmaceutical engineering technology. The key technical features include a horizontal concentration tank with end caps bolted to both sides. A reciprocating mixing mechanism is movably connected to the inner side of the horizontal concentration tank, and a flow guiding mechanism is movably connected to the outer side of the reciprocating mixing mechanism. The main shaft can be driven to rotate in both directions by servo motors on both sides, breaking the regular vortex formed by unidirectional stirring within the horizontal concentration tank. This irregular mixing promotes the flow of the liquid and heat and mass transfer, suppressing local temperature differences and sedimentation. It ensures the stability of heat-sensitive components and enhances the homogenization of the solid and liquid phases through dynamic switching of the rotation direction. This effectively solves the problems of regular vortex formation, low mixing efficiency, and insufficient uniformity caused by unidirectional stirring in traditional low-temperature concentration devices, achieving a dual improvement in concentration efficiency and product quality.

The utility model relates to the field of traditional chinese medicine pharmaceutical engineering discloses a kind of traditional chinese medicine decoction pieces drying sterilization box, including drying cabinet, dust screen is fixedly connected in the upper and lower sides of drying cabinet, fan is fixedly connected in the top middle of drying cabinet, telescopic slide is fixedly connected in the inside bottom of drying cabinet, bracket is fixedly connected in the top of telescopic slide, support block is fixedly connected in the bottom of bracket, a plurality of drying nets are fixedly connected in the inboard of bracket, electric push rod is fixedly connected in the rear side of drying cabinet, push rod is fixedly connected in the output end of electric push rod. In the utility model, by driving electric push rod to push push rod to move forward, push rod will drive bracket to move forward, in turn make the telescopic slide of the bottom of bracket will be stretched out and unfolded forward, until electric push lever will entire bracket be pushed out the inside of drying cabinet, it is realized that user need not reach hand into box body and can be taken or medicinal material is placed on drying net.

The application discloses a preparation method of 3-ketotetrahydrofuran and belongs to the technical field of biological catalysis and pharmaceutical engineering. The application aims to provide an enzymatic oxidation reaction method for obtaining 3-ketotetrahydrofuran with high conversion rate and high yield. In the application, alcohol dehydrogenase mutants are used to catalyze the oxidation of chiral 3-hydroxytetrahydrofuran in a whole cell and a pure enzyme, so that the biosynthesis of 3-ketotetrahydrofuran is realized, the highest yield is 29.73%, and the selectivity is 95.3%. The method has the advantages of mild conditions, environmental friendliness and low cost, and has high application potential.

This application provides a cationic lipid nanovaccine adjuvant and its preparation method, which can be applied to the field of pharmaceutical formulation in pharmaceutical engineering. The method includes: dissolving polylactic acid materials and cationic surfactants in an organic solvent, and ultrasonically mixing them to obtain an oil phase; using ultrapure water as the aqueous phase, uniformly adding the oil phase to the aqueous phase under stirring at a predetermined speed, and continuously stirring until an oil-in-water emulsion is formed; solidifying the oil-in-water emulsion by vacuum evaporation for 3-6 hours at 10-70℃ and -0.01-0.8 Pa to obtain a cationic lipid nanosphere suspension; and circulating and washing the cationic lipid nanosphere suspension with a tangential flow ultrafiltration membrane with a molecular weight cutoff of 100 kDa to obtain the cationic lipid nanovaccine adjuvant.

The utility model discloses a blowdown device of a film evaporator for medicine preparation. The blowdown device comprises a frame; the outer wall of the connecting frame is fixedly connected with the outer wall of the frame; the outer wall of the connecting pipe is fixedly connected with the outer wall of the connecting frame; the outer wall of the adjusting mechanism is rotationally connected with the inner wall of the connecting frame; the outer wall of the scraping mechanism is fixedly connected with the inner wall of the frame through a connecting frame, and the outer wall of the connecting frame is fixedly connected with the inner wall of the frame; the utility model relates to the technical field of pharmaceutical engineering, the scraping mechanism is arranged, sewage impacts on the scraping plate, and the scraping plate is arc-shaped, so that the scraping plate has rotating force, and the scraping plate continuously slides on the inner wall of the frame under the continuous impact of the sewage, so that the inner wall of the frame is cleaned, and the service life of the frame is prolonged. The purpose of the film evaporator blowdown device for medicine preparation is achieved.

The utility model discloses a pulverizing machine for pharmaceutical engineering, and relates to the technical field of pharmaceutical engineering. The powdering machine for pharmaceutical engineering comprises a base, a tank cover and a driving structure, a material tank is rotationally installed in the base, a shaft rod is rotationally installed at the bottom of the inner side of the material tank, a powdering knife is fixedly installed on the outer wall of the shaft rod, a material pipe is fixedly installed on the front side of the material tank, the material pipe is sleeved with a rotary knob cover, the tank cover is arranged at the top of the material tank, and a motor is arranged on the tank cover; a handle is fixedly installed on the top of the tank cover, and the driving structure is arranged on the base and the material tank. According to the pulverizing machine for pharmaceutical engineering, on one hand, medicinal materials in the material tank can be driven to turn over up and down when pulverized, the medicinal materials located at the bottom in the material tank can be shifted to the upper position, the situation that part of the medicinal materials cannot be fully pulverized is reduced, the pulverizing quality is improved, on the other hand, the tank cover is convenient to disassemble, and the practicability is high. And the interior of the material tank is convenient to clean, and subsequent overhaul and maintenance operation of the pulverizing machine is convenient.

This invention discloses a powder mixing pharmaceutical device for pharmaceutical engineering, comprising a cylindrical drum, a fixed plate fixedly connected to the top of the drum, an openable cover hinged to the outer wall of the fixed plate, a motor fixedly connected to the top of the fixed plate, a connecting rod fixedly connected to the output end of the motor, and a mixing mechanism provided on the outer wall of the connecting rod. This relates to the field of pharmaceutical technology. By setting up the mixing mechanism, the bearing disc B rotates on the outer wall of the annular sleeve, causing the spring to deform. Simultaneously, the rotation of the threaded rod and the bearing disc B causes the threaded rod and the bearing disc B to rotate synchronously. Furthermore, the bristles on the outer wall of the stirring rod are agitated by the rotating threaded rod, causing the bristles to rebound due to their own elasticity, rapidly agitating the powder and improving the powder mixing efficiency. The rapid rebound of the bristles also disperses any clumps of powder adhering to the bristles, preventing adhesion from affecting the mixing effect.

The utility model discloses an extrusion forming device, and particularly relates to the technical field of pharmaceutical engineering, the extrusion forming device comprises a bottom assembly, a middle assembly is arranged at the top of the bottom assembly, and a feeding assembly is arranged at the top of the middle assembly; the feeding assembly comprises a motor, the output end of the bottom of the motor is fixedly connected with a rotating gear, the two sides of the rotating gear are engaged with racks, one ends of the racks are fixedly connected with fixing strips, the sides, away from the racks, of the fixing strips are fixedly connected with pushing blocks, the bottoms of the pushing blocks are fixedly connected with a plurality of T-shaped sliding blocks, and inner cavities of the pushing blocks are provided with material storage cavities. A plurality of bevel guide blocks are fixedly connected to the bottom of an inner cavity of the storage cavity, a second lifting base is arranged on the side, away from the motor, of the pushing block, a plurality of upper extrusion columns are fixedly connected to the bottom of the second lifting base, connecting sleeve columns are fixedly connected to the two sides of the second lifting base, and screw rod columns are rotationally connected to inner cavities of the connecting sleeve columns; the bottoms of the lead screw columns are rotationally connected with lead screw lifting machine bodies. The yield is improved, and consumables are reduced.

The invention relates to the technical field of pharmaceutical engineering and powder, and discloses a low-temperature granulation method and system based on a cut spraying type fluidized bed, and the method comprises the following steps: carrying out low-temperature treatment on inlet air of the fluidized bed through an inlet air pre-cooling module, and controlling the working temperature within-5 DEG C to 25 DEG C; the air inlet temperature and humidity are adjusted in real time through a dynamic temperature compensation algorithm; the low-temperature adhesive is atomized based on an ultrasonic-assisted atomization technology, atomization particle size distribution is optimized, and the coefficient of variation is reduced; parameters in the granulation process are monitored in real time through a multi-parameter coupling model, wherein the parameters comprise the retention rate of active ingredients of materials, the porosity of particles and the fluidization state; and when the monitored parameters deviate from the preset range, optimization strategies such as adjustment of the air inlet temperature, change of the adhesive spraying rate and reconstruction of an atomization model are automatically triggered. According to the invention, the problem of activity loss of the heat-sensitive material in the granulating process is effectively solved, and the granulating efficiency and the product quality stability are improved.

The invention belongs to the technical field of pharmaceutical engineering and medical technology, and discloses a medicine dispensing method for realizing diversified preparation of medicines, which comprises the following steps: acquiring prescription information of a patient, determining physical morphological characteristics and chemical stability characteristics of the medicines, and determining individualized adjustment factors of the medicines; generating a dispensing sequence table according to the individualized adjustment factors and the physical morphological characteristics; based on the dispensing sequence table and the chemical stability characteristics, determining an isolation demand level, and distributing a dispensing operation interval according to the isolation demand level; determining a dose segmentation mode of each medicine, and performing dose segmentation on each medicine according to the dose segmentation mode; performing dynamic compatibility verification on the dose segmentation results, and after the verification is passed, combining and packaging all the dose segmentation results so as to obtain a customized medicine combination of the patient; and a technical support is provided for implementation of a precise medical idea in medicine service.

The utility model discloses a medicine material concentration sandwiched layer pot relates to pharmaceutical engineering equipment technical field, and its technical scheme main points are including machine table, the rotatory setting of machine table has the pot body, and the upper mouth of pot body is fixed with the support plate, is provided with motor box on the support plate, and the bottom of motor box is provided with the output shaft, and the telescopic axle rod subassembly is installed to the output shaft bottom, and the both ends of axle rod subassembly are provided with the folding stirring unit, and the axle rod subassembly contracts the stirring unit folding through contraction control, be provided with the trigger component that drives axle rod subassembly telescopic on the machine table, make the pot body when carrying out the shrinkage action of synchronous trigger axle rod subassembly of dumping action. The utility model discloses through being provided with the movable folding stirring unit, cooperate the telescopic axle rod subassembly and trigger component, make the pot body when carrying out dumping medicine, and the stirring unit can synchronous folding, and then expand the clearance of stirring unit and the inner wall of pot body, guarantee that high viscosity medicine can flow smoothly pour, reduce the medicine residue, reduce production cost.

The invention relates to the technical field of pharmaceutical engineering, in particular to a pharmaceutical grade sodium thiosulfate preparation device and a preparation method thereof.The pharmaceutical grade sodium thiosulfate preparation device comprises a frame body, a mixing tank, a plurality of supporting legs and a stirring mechanism, the supporting legs are arranged on the frame body and located at the bottom of the frame body, and the mixing tank is installed on the frame body; the stirring mechanism comprises a double-shaft motor, a transmission assembly, a supporting shaft, a connecting shaft, a stirring rod, a lifting assembly and a sliding part, the supporting shaft is rotatably connected with the frame body, the frame body is provided with a sliding groove, the sliding part is slidably connected with the sliding groove, the connecting shaft is rotatably connected with the sliding part, the stirring rod is fixedly connected with the connecting shaft, and the connecting shaft is slidably connected with the supporting shaft; the double-shaft motor is mounted on the frame body, so that the technical problems that in the prior art, most sodium thiosulfate preparation devices are based on traditional chemical reaction kettles, so that reaction materials are mixed unevenly, local reaction is insufficient, and the purity and yield of final products are affected are solved.

To provide a continuous-flow preparation method for an amino alcohol compound, the method belonging to the technical field of pharmaceutical engineering.SOLUTION: A micro-reaction system comprising a micro-mixer, a micro-channel reactor, and a back pressure device that are sequentially connected is used. The preparation step includes introducing a raw material aldehyde and an amine simultaneously into the micro-mixer to mix and obtain a mixed reaction material, introducing the mixed reaction material into the micro-channel reactor to undergo an addition reaction, and collecting the reaction mixture flowing out of the reactor and subjecting it to concentration and separation purification treatment to obtain an amino alcohol compound. The method has short reaction time, high energy utilization efficiency, low environmental pollution, and is applicable to industrial scale-up.SELECTED DRAWING: Figure 1

The utility model relates to the technical field of pharmaceutical engineering, and discloses a homogenizing and mixing machine for suppositories, which comprises a homogenizing and stirring tank arranged on a table board; the connecting structure comprises a first connecting part and a second connecting part, the first connecting part comprises a top plate fixedly mounted at the top of the homogeneous stirring tank, two groups of first clamping grooves are formed in the top of the top plate, a cover plate is arranged at the top of the homogeneous stirring tank, and two groups of clamping plates are fixedly mounted on the outer wall of the cover plate; the clamping plate is mounted in the first clamping groove in a clamping manner; the second connecting part further comprises two sets of first threaded grooves formed in the top plate, two sets of second threaded grooves are formed in the cover plate, and the second connecting part further comprises limiting bolts arranged in the second threaded grooves, so that the purpose of quickly disassembling and assembling the device is achieved, the use flexibility of the device is improved, and the device is convenient to disassemble and clean; the internal cleaning effect of the device is improved, and the use stability of the device is improved.

The invention belongs to the technical field of pharmaceutical engineering and biology, and discloses coating forming equipment for cosmetic composition, which comprises a rotating cage type cleaning machine, the rotating cage type cleaning machine comprises a shell, flow guide pipes are embedded in the two sides of the shell, a rotating cage is arranged between the two flow guide pipes, and the rotating cage is arranged in the shell. An air pipe is arranged at the position, located on the outer side of the rotating cage, in the rotating cage, an inner separation assembly is fixedly installed at one end of the rotating cage, and a supporting ring is rotationally installed in the middle of the inner separation assembly; the capsule cleaning device has the beneficial effects that a more complex airflow flowing mode can be formed in the rotating cage, so that capsules can be impacted by airflow in all directions, the uniformity and thoroughness of cleaning are further improved, collision and abrasion between the capsules can be reduced, and the surface quality of the capsules is protected.

The invention relates to veterinary recombinant erythropoietin protein as well as a preparation method and application thereof, and belongs to the technical field of biological pharmaceutical engineering. The veterinary recombinant erythropoietin protein contains veterinary erythropoietin protein and an additional peptide fragment, the animal erythropoietin protein comprises dog erythropoietin or cat erythropoietin; the additional peptide fragment comprises a glycosylated rich peptide fragment and / or a basic amino acid peptide fragment. According to the method, the expression quantity of the target protein in host cells is obviously improved, the protein expression quantity is more than 200mg / L, and the expression quantity of the target protein and the recombinant protein without basic amino acid is less than 50mg / L. The biological activity of the target protein is obviously improved, the biological activity is larger than 60000 IU / mg, the biological activity of the cat recombinant erythropoietin is larger than 80000 IU / mg, and the biological activity of the cat recombinant erythropoietin is obviously improved compared with that of recombinant protein without basic amino acid. The expression quantity, the stability and the biological activity of the target protein are improved.

The utility model relates to the technical field of pharmaceutical engineering discloses a tablet press for tablet production, including work table, the top fixedly connected with support of work table, the top inboard fixedly connected with electric telescopic handle of support, the top inwall fixedly connected with hydraulic pressure rod of work table, the bottom of electric telescopic handle is provided with adjusting mechanism, the adjusting mechanism includes the fixed frame fixedly connected in the bottom of electric telescopic handle, and the bottom outer wall fixedly connected with fixed plate of fixed frame, the inwall rotationally connected with rotating column of fixed plate, the outer wall fixedly connected with punch die of connecting plate, the right side of fixed plate is provided with indicating piece, in the utility model, when needing to replace different specifications punch die and its punch box, then the bolt position is released, and then rotating rotating column makes punch die and its punch box rotate, thereby the specification is replaced, and the overall work efficiency is improved.

The invention relates to the technical field of pharmaceutical engineering, in particular to a microwave continuous flow debenzylation method. The method comprises the following steps: mixing a benzyl-containing raw material solution and a debenzylation reagent by a sample injection pump through a micromixer, and pumping the mixture into a microwave continuous flow microchannel reactor to carry out a continuous flow debenzylation reaction. Compared with the prior art, the microwave technology is particularly suitable for being used in combination with a microchannel continuous flow reactor, multi-dimensional control over the reaction retention time, the mixing efficiency, the reaction temperature and the reaction pressure can be achieved, the mass transfer / heat transfer rate is increased, and miniaturization, automation and high-flux amplification of the process are achieved. According to the method, the reaction time can be shortened to several minutes, the technological process is high in continuous automation degree and space time yield, operation is easy and convenient, production is safe, cost is low, and industrial production is easy.

The utility model relates to the technical field of pharmaceutical engineering, and discloses a Chinese herbal medicine component separation and concentration device structure which comprises an extraction tank, a feeding box is fixedly connected to the upper surface of the extraction tank, an opening and closing assembly is fixedly connected to the outer wall of the feeding box, and a hinge is fixedly connected to the outer wall of the extraction tank. A bottom cover is fixedly connected to the outer wall of a hinge, an air cylinder is rotatably connected to the outer wall of the extraction tank, a supporting rod is connected to the output end of the air cylinder, a conveying pipe is fixedly connected to the interior of the extraction tank, a concentration tank is fixedly connected to the outer wall of the conveying pipe, and a steam valve is fixedly connected to the interior of the extraction tank. And a solvent valve is fixedly connected to the interior of the extraction tank. According to the feeding device, the second motor is started to drive the first connecting rod, so that the second connecting rod is driven, the third fixing rod and the third connecting rod are further driven, and the feeding cover is further opened, so that the effects of improving the feeding efficiency and further improving the efficiency of the whole production process can be achieved.

This invention provides an oral liquid preparation data monitoring system based on diaphragm valve feedback signals, belonging to the field of pharmaceutical engineering technology. The method includes: collecting feedback signals from multiple diaphragm valves during the oral liquid preparation process, including valve core switch status signals, downstream pressure feedback signals, and flow sensor linkage signals; preprocessing the feedback signals by signal filtering and error correction to obtain preprocessed stable signal data; dynamically determining detection nodes at the diaphragm valve outlet end in the inner wall region of the delivery pipe based on the preprocessed stable signal data; obtaining dynamic geometric figures based on the spatial coordinates of the detection nodes; and calculating the instantaneous flow rate and cumulative delivery volume of the material delivery pipeline based on the dynamic geometric figures to obtain an instantaneous flow rate data stream. This invention can solve the problems of low accuracy, slow response, and reliance on manual labor in existing technologies, and improve the intelligence and reliability of the oral liquid preparation process.

The present application relates to the technical field of pharmaceutical engineering, and particularly relates to a high-efficiency tablet press for tablet manufacturing, which comprises an isolation box, a feeding assembly, a pressing assembly, a feeding assembly, a pressing forming die, a pushing mechanism and a ejection assembly, two pressing forming dies are arranged in the middle end of the isolation box, a pressing assembly is arranged on the outer side of the upper end of each pressing forming die, a feeding assembly is arranged on the inner side of the upper end of each pressing forming die, an ejection assembly is arranged on the outer side of the lower end of each pressing forming die, and a pushing mechanism is arranged on the inner side of the middle part of each pressing forming die, and a feeding assembly is arranged on the upper end of each feeding assembly. The present application is provided with two groups of feeding assemblies, pressing assemblies, feeding assemblies, pressing forming dies, pushing mechanisms and ejection assemblies, which are high in processing efficiency, accurate in quantitative feeding, high in product quality, good in overall sealing, and capable of avoiding cross-contamination of tablets and affecting the medicinal effect.

1. Name of the product in this design: Centrifuge (Pharmaceutical Engineering). 2. Application of this design: This design is used for the separation of pharmaceutical materials. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

The invention provides a Shenfu injection alcohol solution pH overshoot control method, device and equipment and a storage medium, and relates to the technical field of traditional Chinese medicine pharmaceutical engineering. The control method comprises the following steps: acquiring an initial volume of a to-be-adjusted liquid medicine and calculating a predicted total alkali amount; adding first-stage alkali liquor until a preset inflection point proportion is reached; adding of the alkali liquor is stopped, and the real-time pH value is measured; if the real-time pH value is within the inflection point pH range, marking the current accumulated alkali adding amount as the actual inflection point alkali adding amount, and calculating the residual required alkali adding amount; and adding the residual required alkali into the to-be-adjusted liquid medicine. According to the invention, model prediction is combined with segmented control, and intermittent cleaning measurement is utilized to thoroughly solve the problem of detection misalignment caused by precipitation interference on the electrode. Meanwhile, based on a dynamic calibration mechanism of inflection point actual measurement data, control deviation of a nonlinear system is effectively overcome, accurate locking of a pH end point is achieved, effective components are prevented from being decomposed due to overshoot, and production efficiency and medicine quality are remarkably improved.

The utility model discloses a medicine drying device for medical engineering, which comprises a drying box protective shell and an electric heater, the front end of the drying box protective shell is rotatably connected with a box door, the outer side of the top end of the drying box protective shell is fixedly provided with a U-shaped exhaust pipe, and the inner side of the drying box protective shell is fixedly connected with a drying box. Supporting rods are evenly and fixedly connected to the two sides of the inner side of the drying box correspondingly, a backflow cavity is formed between the drying box protection shell and the drying box, exhaust grooves are evenly formed in the top end of the drying box in a penetrating mode, and discharging openings are formed in the middles of the bottom ends of the two sides of the drying box protection shell in a penetrating mode correspondingly. Water vapor and hot air generated in the drying process enter the backflow cavity through the exhaust grooves, secondary heating is conducted on the outer side of the drying box, the heat preservation effect is enhanced, heat loss is reduced through the design, energy consumption is reduced, and drying efficiency is improved.

The invention belongs to the technical field of pharmaceutical engineering, and particularly relates to a multi-stereocenter chiral compound isomer in-situ rapid detection device and method. The device comprises a reactor, a pump, a continuous filter, a storage tank, a solvent storage tank, a continuous oil-water separator, a continuous distiller and an ion mobility mass spectrometer. The method comprises the steps of reaction liquid extraction, continuous filtration, continuous oil-water separation, continuous distillation, continuous sample introduction and the like. The method provided by the invention solves the difficult problem of rapid and accurate determination of the stereoisomer in the synthesis process of the multi-stereocenter chiral compound, and has the advantages of high detection speed, high sensitivity, high accuracy, high reliability and the like.