75 results about "Pharmaceutical engineering" patented technology

The invention relates to the technical field of traditional Chinese medicine pharmaceutical engineering, and discloses a traditional Chinese medicine decoction piece decoction water adding amount calculation method based on deep learning, which comprises the following steps: step 1, acquiring three-dimensional form data and physical parameter data of traditional Chinese medicine decoction pieces, and inputting the three-dimensional form data and the physical parameter data into a deep time sequence neural network to generate a dynamic water absorption curve template; 2, collecting decoction process data in real time through a liquid level sensor, a temperature sensor and a conductivity sensor which are arranged in a decoction container, and performing real-time deviation analysis on the decoction process data and the dynamic water absorption curve template; and step 3, generating a water adding amount adjusting instruction according to the real-time deviation analysis result. According to the method, a multi-modal sensing fusion technical scheme is adopted, the technical effect of accurately constructing the water absorption behavior model of the decoction pieces is achieved, and compared with an analysis method of single sensing data in the prior art, the technical defect that dynamic prediction of water absorption is inaccurate due to insufficient information dimensions in a traditional method is overcome.

The utility model relates to the technical field of pharmaceutical engineering, and discloses a crushing and extracting mechanism for separating traditional Chinese medicine components, which comprises a base, an immersion barrel and a crushing box are assembled at the top of the base, a discharge port is assembled between the immersion barrel and the crushing box, a feed port is arranged at the top of the crushing box, and a discharge port is arranged at the bottom of the crushing box. A screening assembly and a grinding assembly are arranged in the smashing box, a temperature control assembly is arranged on the outer side of the immersion barrel, a liquid inlet pipe is assembled on the top of the immersion barrel, a liquid outlet pipe is assembled at the bottom of the immersion barrel, the screening assembly comprises a first motor, and the first motor is assembled in the middle of the smashing box. According to the utility model, under the cooperation of the motor I, the eccentric block, the screen, the spring rod and other structures, impurities are effectively prevented from being mixed into the leaching liquor, the subsequent purification process is smoothly and efficiently carried out, the purity of the leaching liquor is powerfully guaranteed, and a foundation is built for the output of high-quality traditional Chinese medicine components.

The present invention belongs to the field of biotechnology and pharmaceutical engineering technology, and discloses a functionalized drug-loaded exosome based on milk exosomes, a preparation method thereof, and an application thereof. The functionalized drug-loaded exosomes include a carrier and a water-insoluble drug, and the water-insoluble drug is loaded inside the carrier; wherein the surface of the carrier is loaded with milk exosomes with functionalized molecules, and the functionalized molecule is any one of phosphatidylserine, a molecule capable of macrophage targeting, and a molecule or polymer that enhances the targeting and stability of milk exosomes; the water-insoluble drug is any one of an antibacterial drug, an antitumor drug, and a gene drug. The functionalized drug-loaded exosomes in the present invention can improve the gastrointestinal stability of oral administration and enhance the efficacy against bacterial pathogens; expand the application scope of milk exosomes in the fields of anti-intestinal bacterial infection and food preservation, and the exosome content in milk is very rich, which is convenient for large-scale preparation and has important application value.

The invention relates to the technical field of traditional Chinese medicine pharmaceutical engineering, and particularly discloses a traditional Chinese medicine extraction and concentration intelligent control system and method based on multi-modal sensing and deep reinforcement learning. The system comprises a multi-modal sensing layer, an edge computing gateway, an intelligent decision-making layer and an expert knowledge base; the edge computing gateway inputs the multi-dimensional time sequence data of the 30-second window into a mixed time sequence prediction model composed of a TCN and double LSTMs, and outputs a sudden boiling risk probability; when the sudden boiling risk probability is lower than a threshold value, an intelligent decision-making layer adopts combined control to generate a fine control quantity, when the sudden boiling risk probability is greater than or equal to 0.95, sudden boiling emergency interlocking is triggered, a main steam valve is closed within 0.5 second, and a vacuum buffer tank is linked to reduce the pressure in the kettle to a safe vacuum zone; and the expert knowledge base applies temperature and vacuum safety constraints to the deep reinforcement learning reward function to ensure that the control action does not cross the medicinal material safety boundary, and automatic control with safe and stable whole process and determinable end point is realized.

The invention relates to the field of pharmaceutical engineering and automatic control, in particular to a reaction kettle for synthesizing a medical intermediate and an intelligent control method of the reaction kettle. The reaction kettle comprises a reaction kettle main body, a stirring assembly integrated with a dynamic torque sensor and a thermotechnical pipeline assembly, the system firstly executes no-load calibration to draw a mechanical friction loss curve and a heat transfer coefficient map; deducting friction reference inversion apparent viscosity by using real-time torque during operation, and judging a reaction stage in combination with a reaction heat rate; then dynamic heat balance control is executed, and a medium temperature change compensation strategy or a rotating speed shearing strategy is selected to be executed according to the heat transfer deviation; the method is characterized in that high-precision viscosity inversion is achieved by eliminating mechanical friction interference, the polymerization degree or the crystallization state is visually monitored on the premise that the closed environment is not damaged, and the problem that the reaction process is invisible in the prior art is solved.

This utility model discloses a pulping device for preparing earthworm extract, relating to the field of pharmaceutical engineering. It includes a tank, with connecting boxes fixedly connected to both sides of the tank. An electric push rod is installed inside the connecting boxes, and a moving block is fixedly connected to the upper end of the electric push rod. Slider blocks are fixedly connected to both sides of the moving block, and ball bearings are installed inside the sliders. A connecting rod is fixedly connected to the upper end of the sliders. The advantages of this utility model are: the electric push rod, moving block, slider, scraper ring, and sliding rod enable the scraper ring to circulate and reciprocate within the tank, thereby promptly scraping away the earthworm raw material adhering to the inner wall, ensuring it returns to the pulping area for further pulverization, and improving the uniformity of pulping; the short rod, retaining ring, spring, limiting rod, and short block enable quick loading and unloading of the filter plate, facilitating maintenance during long-term use and reducing maintenance difficulty.

The invention relates to a decontamination method, in particular for use in pharmaceutical engineering, characterized by the following method steps: introducing a decontamination agent into at least one gas line (07) for supplying at least one atomizer (04) with a carrier gas flow, preferably compressed air; the atomizer is arranged in the isolation space (02) and is preferably realized as a two-fluid nozzle; the at least one atomizer (04) is supplied with a decontaminating liquid, preferably hydrogen peroxide, by a decontaminating agent storage container (06) via a valve device controlled by an electronic control device in order to generate a decontaminating aerosol during a decontaminating operation of the isolated space (02); the at least one atomizer (04) is connected in a gas-conducting manner to a gas pressure source (08) via the gas line (07), and a filter (11) for filtering the carrier gas flow is arranged in the gas line (07) between the gas pressure source (08) and the atomizer (04), preferably separately configured for each atomizer (04).

The present invention relates to the fields of pharmaceutical engineering and medical technology, and particularly to a compound with anti-lung cancer activity, a preparation method thereof, and an application thereof. In the present invention, an ionic liquid is used as a solvent, and Z-2-chloromethyl-3-phenylacrylic acid, 3-p-chlorophenylacrolein, benzylamine, and cyclohexyl isocyanide are used as raw materials, and a compound with anti-lung cancer activity is obtained through a microwave-assisted one-pot reaction. The method of the present invention has the characteristics of simplicity, low cost, and greenness, and the prepared compound with anti-lung cancer activity has a good effect of inhibiting the proliferation and inducing apoptosis of lung cancer cells.

This utility model discloses a low-temperature concentration device for a traditional Chinese medicine probiotic hangover remedy, belonging to the field of pharmaceutical engineering technology. The key technical features include a horizontal concentration tank with end caps bolted to both sides. A reciprocating mixing mechanism is movably connected to the inner side of the horizontal concentration tank, and a flow guiding mechanism is movably connected to the outer side of the reciprocating mixing mechanism. The main shaft can be driven to rotate in both directions by servo motors on both sides, breaking the regular vortex formed by unidirectional stirring within the horizontal concentration tank. This irregular mixing promotes the flow of the liquid and heat and mass transfer, suppressing local temperature differences and sedimentation. It ensures the stability of heat-sensitive components and enhances the homogenization of the solid and liquid phases through dynamic switching of the rotation direction. This effectively solves the problems of regular vortex formation, low mixing efficiency, and insufficient uniformity caused by unidirectional stirring in traditional low-temperature concentration devices, achieving a dual improvement in concentration efficiency and product quality.

The present invention relates to a method for preparing controlled-release enzyme-loaded microspheres for preventing and treating skin photoaging and their application, belonging to the field of pharmaceutical engineering drug preparations. The present invention's preparation method produces controlled-release enzyme-loaded microspheres loaded with cathepsin D and cathepsin K, combining the advantages of microsphere controlled release with the therapeutic strategy of cathepsins. The resulting microspheres have the effect of preventing and treating skin photoaging, representing a major breakthrough in the research and development of specific drugs for preventing and treating photoaging and related skin lesions. The present invention can provide a new strategy for developing better small-molecule drugs for the prevention and treatment of photoaging and related skin diseases, and has important theoretical and practical value.

The utility model relates to the field of traditional chinese medicine pharmaceutical engineering discloses a kind of traditional chinese medicine decoction pieces drying sterilization box, including drying cabinet, dust screen is fixedly connected in the upper and lower sides of drying cabinet, fan is fixedly connected in the top middle of drying cabinet, telescopic slide is fixedly connected in the inside bottom of drying cabinet, bracket is fixedly connected in the top of telescopic slide, support block is fixedly connected in the bottom of bracket, a plurality of drying nets are fixedly connected in the inboard of bracket, electric push rod is fixedly connected in the rear side of drying cabinet, push rod is fixedly connected in the output end of electric push rod. In the utility model, by driving electric push rod to push push rod to move forward, push rod will drive bracket to move forward, in turn make the telescopic slide of the bottom of bracket will be stretched out and unfolded forward, until electric push lever will entire bracket be pushed out the inside of drying cabinet, it is realized that user need not reach hand into box body and can be taken or medicinal material is placed on drying net.

The application discloses a preparation method of 3-ketotetrahydrofuran and belongs to the technical field of biological catalysis and pharmaceutical engineering. The application aims to provide an enzymatic oxidation reaction method for obtaining 3-ketotetrahydrofuran with high conversion rate and high yield. In the application, alcohol dehydrogenase mutants are used to catalyze the oxidation of chiral 3-hydroxytetrahydrofuran in a whole cell and a pure enzyme, so that the biosynthesis of 3-ketotetrahydrofuran is realized, the highest yield is 29.73%, and the selectivity is 95.3%. The method has the advantages of mild conditions, environmental friendliness and low cost, and has high application potential.

This application provides a cationic lipid nanovaccine adjuvant and its preparation method, which can be applied to the field of pharmaceutical formulation in pharmaceutical engineering. The method includes: dissolving polylactic acid materials and cationic surfactants in an organic solvent, and ultrasonically mixing them to obtain an oil phase; using ultrapure water as the aqueous phase, uniformly adding the oil phase to the aqueous phase under stirring at a predetermined speed, and continuously stirring until an oil-in-water emulsion is formed; solidifying the oil-in-water emulsion by vacuum evaporation for 3-6 hours at 10-70℃ and -0.01-0.8 Pa to obtain a cationic lipid nanosphere suspension; and circulating and washing the cationic lipid nanosphere suspension with a tangential flow ultrafiltration membrane with a molecular weight cutoff of 100 kDa to obtain the cationic lipid nanovaccine adjuvant.

The utility model discloses a blowdown device of a film evaporator for medicine preparation. The blowdown device comprises a frame; the outer wall of the connecting frame is fixedly connected with the outer wall of the frame; the outer wall of the connecting pipe is fixedly connected with the outer wall of the connecting frame; the outer wall of the adjusting mechanism is rotationally connected with the inner wall of the connecting frame; the outer wall of the scraping mechanism is fixedly connected with the inner wall of the frame through a connecting frame, and the outer wall of the connecting frame is fixedly connected with the inner wall of the frame; the utility model relates to the technical field of pharmaceutical engineering, the scraping mechanism is arranged, sewage impacts on the scraping plate, and the scraping plate is arc-shaped, so that the scraping plate has rotating force, and the scraping plate continuously slides on the inner wall of the frame under the continuous impact of the sewage, so that the inner wall of the frame is cleaned, and the service life of the frame is prolonged. The purpose of the film evaporator blowdown device for medicine preparation is achieved.

The invention relates to an auxiliary device for cutting an ampoule bottle, and relates to the technical field of pharmaceutical engineering, the auxiliary device comprises a shell, the interior of the shell is divided into an operation cavity located on the upper portion and a control cavity located on the lower portion through a fixing plate, and the fixing plate is connected with a mounting plate through a rotating mechanism; three corners of the mounting plate are connected with tungsten steel cutters through transmission shafts, the top end of the shell is connected with a first motor movably mounted in a rotating hole in the shell through a locking mechanism, an output shaft of the first motor is meshed with a second transmission gear at the top end of the transmission shaft through a first transmission gear, and a cutting opening is formed in a front panel of the shell. And a knife edge of the tungsten steel knife extends out of the cutting opening. In the using process, switching of different tungsten steel knives can be rapidly achieved, the service life of the tungsten steel knives is greatly prolonged, the knife flywheel can be used in an alternative mode and can be replaced without shutdown, and the productivity of the pharmaceutical machine is greatly improved.

The utility model relates to the technical field of pharmaceutical engineering, and discloses a slurry adding assembly which is characterized in that an anti-blocking assembly is arranged inside and at the top of a connecting pipeline; a wet granulation device comprises a workbench, a stirring bin, a granulator and a control module. According to the slurry adding assembly and the wet granulation device, the rotating rod is driven by the small motor to rotate, the rotating rod is in threaded connection with the top of the connecting pipeline, and the connecting pipeline is fixed, so that the rotating rod moves downwards, meanwhile, the small motor is driven by the motor protection base and the connecting steel rail to move along with the rotating rod, and the stability of the structure is guaranteed; when the rotating rod moves, the push rod at the end of the rotating rod pushes slurry in the pipeline to prevent the slurry from blocking the pipeline, and the second baffle ring at the end of the rotating rod not only supports the connecting steel rail, but also can prevent the slurry from sticking to the outside of the rotating rod to block the rotating rod. The rotatable design of the control module is convenient for a user to adjust the angle of the controller according to actual conditions so as to facilitate the use of the controller.

The utility model discloses a pulverizing machine for pharmaceutical engineering, and relates to the technical field of pharmaceutical engineering. The powdering machine for pharmaceutical engineering comprises a base, a tank cover and a driving structure, a material tank is rotationally installed in the base, a shaft rod is rotationally installed at the bottom of the inner side of the material tank, a powdering knife is fixedly installed on the outer wall of the shaft rod, a material pipe is fixedly installed on the front side of the material tank, the material pipe is sleeved with a rotary knob cover, the tank cover is arranged at the top of the material tank, and a motor is arranged on the tank cover; a handle is fixedly installed on the top of the tank cover, and the driving structure is arranged on the base and the material tank. According to the pulverizing machine for pharmaceutical engineering, on one hand, medicinal materials in the material tank can be driven to turn over up and down when pulverized, the medicinal materials located at the bottom in the material tank can be shifted to the upper position, the situation that part of the medicinal materials cannot be fully pulverized is reduced, the pulverizing quality is improved, on the other hand, the tank cover is convenient to disassemble, and the practicability is high. And the interior of the material tank is convenient to clean, and subsequent overhaul and maintenance operation of the pulverizing machine is convenient.

The present invention relates to the technical field of pharmaceutical engineering, and specifically relates to a preparation method of tacrolimus position isomers. By introducing the catalyst tetrakis(triphenylphosphine)palladium during the reaction process, it is possible to prepare tacrolimus position isomers with relatively high purity on the basis of reducing the reaction temperature. Compared with the prior art, it has the technical advantage of low-temperature reaction, resulting in the technical effects of reducing side reactions in the overall reaction, lowering the purification difficulty, and increasing the product yield.

The invention relates to the technical field of pharmaceutical engineering, in particular to a production method and a preservation method for reducing temperature sensitivity of a Nicodil bulk drug. The method comprises the following steps: by taking ethanolamine and nicotinic acid as initial raw materials, carrying out nitration reaction on ethanolamine and fuming nitric acid to obtain a first intermediate; nicotinic acid and thionyl chloride are subjected to an acylation reaction to generate a dichloromethane solution in an intermediate state of nicotinic acid, and then the dichloromethane solution in the intermediate state of nicotinic acid and the first intermediate are subjected to an addition reaction to generate a crude nicorandil product; and refining the crude product of Nicodil with isopropanol to obtain a finished product of Nicodil, specifically comprising the following steps: adding the crude product of Nicodil and isopropanol in a reaction container according to a feeding mass ratio of 1: 6, heating to below 50 DEG C, stirring for dissolving, filtering, collecting filtrate, cooling to-10-0 DEG C, stirring for crystallization for 4-5 hours, filtering, collecting a filter cake, and drying to obtain the finished product of Nicodil. And drying the filter cake at 40-50 DEG C under reduced pressure for not less than 6 hours to obtain the finished product of Nicodil.

The utility model discloses a dialysis type bio-pharmaceutical engineering wastewater treatment device, and relates to the technical field of bio-pharmaceutical wastewater treatment.The dialysis type bio-pharmaceutical engineering wastewater treatment device comprises a filter box, a treatment mechanism and an adsorption mechanism, the filter box is connected with the treatment mechanism through a first connecting pipeline, and the treatment mechanism is connected with the adsorption mechanism through a second connecting pipeline; the filter box is connected with a water inlet pipeline, the adsorption mechanism is connected with a water outlet pipeline, and a filter frame corresponding to an outlet of the water inlet pipeline is connected in the filter box. Wastewater falls into the filtering frame through the water inlet pipeline, impurities in the wastewater are filtered into the filtering frame, and water passes through the filtering frame and falls to the bottom of the filtering box, so that separation of the water and the impurities is realized, and the impurities in the wastewater are reduced.

1. The name of this design product: Fluid power pump (chemically corrosive). 2. Purpose of this product with this design: This product with this design is used for the transportation of multifunctional chemical corrosive fluids, wastewater treatment fluid transportation, waste acid purification treatment fluid transportation, phosphorus chemical corrosive fluid transportation, agricultural pharmaceutical engineering corrosive fluid transportation, electronic semiconductor corrosive fluid transportation, pharmaceutical engineering corrosive fluid transportation, and food engineering corrosive fluid transportation. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

This invention discloses a powder mixing pharmaceutical device for pharmaceutical engineering, comprising a cylindrical drum, a fixed plate fixedly connected to the top of the drum, an openable cover hinged to the outer wall of the fixed plate, a motor fixedly connected to the top of the fixed plate, a connecting rod fixedly connected to the output end of the motor, and a mixing mechanism provided on the outer wall of the connecting rod. This relates to the field of pharmaceutical technology. By setting up the mixing mechanism, the bearing disc B rotates on the outer wall of the annular sleeve, causing the spring to deform. Simultaneously, the rotation of the threaded rod and the bearing disc B causes the threaded rod and the bearing disc B to rotate synchronously. Furthermore, the bristles on the outer wall of the stirring rod are agitated by the rotating threaded rod, causing the bristles to rebound due to their own elasticity, rapidly agitating the powder and improving the powder mixing efficiency. The rapid rebound of the bristles also disperses any clumps of powder adhering to the bristles, preventing adhesion from affecting the mixing effect.

The utility model discloses an extrusion forming device, and particularly relates to the technical field of pharmaceutical engineering, the extrusion forming device comprises a bottom assembly, a middle assembly is arranged at the top of the bottom assembly, and a feeding assembly is arranged at the top of the middle assembly; the feeding assembly comprises a motor, the output end of the bottom of the motor is fixedly connected with a rotating gear, the two sides of the rotating gear are engaged with racks, one ends of the racks are fixedly connected with fixing strips, the sides, away from the racks, of the fixing strips are fixedly connected with pushing blocks, the bottoms of the pushing blocks are fixedly connected with a plurality of T-shaped sliding blocks, and inner cavities of the pushing blocks are provided with material storage cavities. A plurality of bevel guide blocks are fixedly connected to the bottom of an inner cavity of the storage cavity, a second lifting base is arranged on the side, away from the motor, of the pushing block, a plurality of upper extrusion columns are fixedly connected to the bottom of the second lifting base, connecting sleeve columns are fixedly connected to the two sides of the second lifting base, and screw rod columns are rotationally connected to inner cavities of the connecting sleeve columns; the bottoms of the lead screw columns are rotationally connected with lead screw lifting machine bodies. The yield is improved, and consumables are reduced.

1. The name of this design product: tablet measuring instrument. 2. Purpose of this product with design: This product with design is used for measuring tablets in pharmaceutical engineering. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The invention relates to the technical field of biotechnology and pharmaceutical engineering, in particular to a fiveleaf gynostemma herb component separation method and system based on ultrasonic-assisted membrane combining.The method comprises the steps that an initial fiveleaf gynostemma herb set is obtained, a target fiveleaf gynostemma herb set is obtained based on the initial fiveleaf gynostemma herb set, and a fiveleaf gynostemma herb experimental group set is extracted from the target fiveleaf gynostemma herb experimental group set; obtaining a target crushing curve based on the gynostemma pentaphyllum experimental group and the crushing parameter set, extracting a target crushing parameter group from the target crushing curve, obtaining analyzed crushed gynostemma pentaphyllum by using the target crushing parameter group, obtaining an analyzed gynostemma pentaphyllum mixed solution based on the analyzed crushed gynostemma pentaphyllum, and determining a target ultrasonic parameter group based on the ultrasonic parameter set and analyzing the gynostemma pentaphylla mixed solution, obtaining a target gynostemma pentaphylla crude solution by using the target ultrasonic parameter group, obtaining a target screening parameter group based on the initial screening parameter set, and obtaining a target extracting solution by using the target screening parameter group. According to the method, the gynostemma pentaphylla component separation accuracy and efficiency can be improved.

The invention relates to the technical field of pharmaceutical engineering and powder, and discloses a low-temperature granulation method and system based on a cut spraying type fluidized bed, and the method comprises the following steps: carrying out low-temperature treatment on inlet air of the fluidized bed through an inlet air pre-cooling module, and controlling the working temperature within-5 DEG C to 25 DEG C; the air inlet temperature and humidity are adjusted in real time through a dynamic temperature compensation algorithm; the low-temperature adhesive is atomized based on an ultrasonic-assisted atomization technology, atomization particle size distribution is optimized, and the coefficient of variation is reduced; parameters in the granulation process are monitored in real time through a multi-parameter coupling model, wherein the parameters comprise the retention rate of active ingredients of materials, the porosity of particles and the fluidization state; and when the monitored parameters deviate from the preset range, optimization strategies such as adjustment of the air inlet temperature, change of the adhesive spraying rate and reconstruction of an atomization model are automatically triggered. According to the invention, the problem of activity loss of the heat-sensitive material in the granulating process is effectively solved, and the granulating efficiency and the product quality stability are improved.

The invention belongs to the technical field of pharmaceutical engineering and medical technology, and discloses a medicine dispensing method for realizing diversified preparation of medicines, which comprises the following steps: acquiring prescription information of a patient, determining physical morphological characteristics and chemical stability characteristics of the medicines, and determining individualized adjustment factors of the medicines; generating a dispensing sequence table according to the individualized adjustment factors and the physical morphological characteristics; based on the dispensing sequence table and the chemical stability characteristics, determining an isolation demand level, and distributing a dispensing operation interval according to the isolation demand level; determining a dose segmentation mode of each medicine, and performing dose segmentation on each medicine according to the dose segmentation mode; performing dynamic compatibility verification on the dose segmentation results, and after the verification is passed, combining and packaging all the dose segmentation results so as to obtain a customized medicine combination of the patient; and a technical support is provided for implementation of a precise medical idea in medicine service.

The utility model discloses a medicine material concentration sandwiched layer pot relates to pharmaceutical engineering equipment technical field, and its technical scheme main points are including machine table, the rotatory setting of machine table has the pot body, and the upper mouth of pot body is fixed with the support plate, is provided with motor box on the support plate, and the bottom of motor box is provided with the output shaft, and the telescopic axle rod subassembly is installed to the output shaft bottom, and the both ends of axle rod subassembly are provided with the folding stirring unit, and the axle rod subassembly contracts the stirring unit folding through contraction control, be provided with the trigger component that drives axle rod subassembly telescopic on the machine table, make the pot body when carrying out the shrinkage action of synchronous trigger axle rod subassembly of dumping action. The utility model discloses through being provided with the movable folding stirring unit, cooperate the telescopic axle rod subassembly and trigger component, make the pot body when carrying out dumping medicine, and the stirring unit can synchronous folding, and then expand the clearance of stirring unit and the inner wall of pot body, guarantee that high viscosity medicine can flow smoothly pour, reduce the medicine residue, reduce production cost.

The invention relates to the technical field of pharmaceutical engineering, in particular to a pharmaceutical grade sodium thiosulfate preparation device and a preparation method thereof.The pharmaceutical grade sodium thiosulfate preparation device comprises a frame body, a mixing tank, a plurality of supporting legs and a stirring mechanism, the supporting legs are arranged on the frame body and located at the bottom of the frame body, and the mixing tank is installed on the frame body; the stirring mechanism comprises a double-shaft motor, a transmission assembly, a supporting shaft, a connecting shaft, a stirring rod, a lifting assembly and a sliding part, the supporting shaft is rotatably connected with the frame body, the frame body is provided with a sliding groove, the sliding part is slidably connected with the sliding groove, the connecting shaft is rotatably connected with the sliding part, the stirring rod is fixedly connected with the connecting shaft, and the connecting shaft is slidably connected with the supporting shaft; the double-shaft motor is mounted on the frame body, so that the technical problems that in the prior art, most sodium thiosulfate preparation devices are based on traditional chemical reaction kettles, so that reaction materials are mixed unevenly, local reaction is insufficient, and the purity and yield of final products are affected are solved.

To provide a continuous-flow preparation method for an amino alcohol compound, the method belonging to the technical field of pharmaceutical engineering.SOLUTION: A micro-reaction system comprising a micro-mixer, a micro-channel reactor, and a back pressure device that are sequentially connected is used. The preparation step includes introducing a raw material aldehyde and an amine simultaneously into the micro-mixer to mix and obtain a mixed reaction material, introducing the mixed reaction material into the micro-channel reactor to undergo an addition reaction, and collecting the reaction mixture flowing out of the reactor and subjecting it to concentration and separation purification treatment to obtain an amino alcohol compound. The method has short reaction time, high energy utilization efficiency, low environmental pollution, and is applicable to industrial scale-up.SELECTED DRAWING: Figure 1