296 results about "Tissue fluid" patented technology

The invention relates to an extraction electrode voltage determining method, device and system, a continuous blood glucose monitoring device comprises an extraction electrode, the extraction electrode is attached to the skin surface of a user, and the method comprises the steps that first loading voltage of the extraction electrode is obtained; under the condition that the extraction electrode is loaded with the first loading voltage, the current value of first current flowing through the skin surface of the user is determined; and when the current value of the first current is within a preset current value range, determining the first loading voltage as the loading voltage for an extraction electrode to extract the tissue fluid of the corresponding user.

According to the valve type opening and closing hysteroscope, before examination or operation, when an opening and closing valve is in a closed state and reaches an examination position or an operation position, the opening and closing valve is opened through an opening and closing handle, the opening and closing valve can open the examination position or the operation position, and examination or operation is conducted through a micropore camera on an imaging seat; when tissue fluid or blood blocks an examination position or an operation position, the flushing fluid assembly pumps flushing fluid into the examination position or the operation position, after flushing, the vacuum extraction assembly is started to suck away mixed fluid of the tissue fluid or the blood and the flushing fluid through the negative pressure suction hole, and after examination or operation is completed, the opening and closing valve is closed through the opening and closing handle, and the flushing fluid or the flushing fluid is pumped into the examination position or the operation position. In this way, the problem that tissue fluid or blood flowing out of the human body blocks the view field of the hysteroscope can be effectively solved, and when the opening and closing valve is closed, the imaging assembly is in a streamline shape and can conveniently stretch into the hysteroscope for examination or operation.

The invention discloses a quality detection device for mesenchymal stem cells in the technical field of cell detection, and the quality detection device comprises a bracket and two culture dishes, and the two culture dishes are symmetrically distributed on the left and right sides of the bracket; a circulation mechanism is arranged on the bracket and is used for connecting the two culture dishes so that tissue fluid in the two culture dishes can circulate mutually; butt joint mechanisms are symmetrically arranged on the left side and the right side of the bracket, and are used for butt joint of the culture dishes and the circulation mechanism in a sealing manner; according to the device, tissue fluid in a culture dish in which mesenchymal stem cell tissue fluid is cultured circulates into another empty culture dish through a circulation mechanism, each mesenchymal stem cell can be detected in real time through a detection mechanism in the circulation process, and the mesenchymal stem cell tissue fluid continuously flows through a monitoring point, so that the mesenchymal stem cell tissue fluid can be detected in real time; therefore, the influence on the culture of the mesenchymal stem cells due to long-time illumination can be effectively avoided.

The invention provides a flap retractor for breast cancer surgery, and belongs to the technical field of medical instruments. Comprising an arc-shaped frame, third bent parts are arranged at the two ends of the arc-shaped frame, rebound frames are fixedly connected to the inner walls of the two ends of the arc-shaped frame, air bags are installed in the rebound frames, and second connectors are fixedly connected to the outer walls of the air bags; the drainage assembly is used for sucking interstitial fluid at the incision position of the skin flap, and the drainage assembly is connected with the arc-shaped frame and the rebound frame. By arranging the arc-shaped frame, the position of a skin flap incision can be supported and pulled, the skin flap incision is pulled and opened by means of the air bag and the rebound frame, by means of the pulling mode, operation is convenient and labor-saving, an operator does not need to continuously hold and apply force with hands in the actual operation process, manpower and material resources are saved, and the working efficiency is improved. And the size of the opening of the skin flap incision is controlled according to the air filled in the air bag, so that the control of the size of the opening is more stable, and the accuracy is higher.

The utility model relates to the technical field of medical instruments, in particular to a pair of anti-slip rotatable bent three-blade forceps with a suction function for laparoscopic surgery, which comprises a forceps seat, blades, an opening mechanism, a forceps tube, a rotating mechanism, an inner tube, a rotating wheel, a pull rod, a pull wire, a handle and a suction tube, the blade is connected with the clamp seat through an opening mechanism, a rotating opening is formed in the head end of the clamp pipe, the clamp seat is installed on the rotating opening, the inner pipe is located in a pipe cavity of the clamp pipe, a rotating hole is formed in the tail end of the clamp pipe, the inner pipe penetrates through the rotating hole, the head end of the inner pipe is connected with the clamp seat through a rotating mechanism, and the rotating axis of the clamp seat is perpendicular to the rotating axis of the inner pipe. The utility model has the advantages that the front end of the blade is provided with the arc-shaped hook claw, so that deep pelvic tissues can be firmly grasped, and slipping can be effectively avoided; the rotating wheel is operated to adjust the angle of the clamp seat at the rotating opening through the inner pipe and the rotating mechanism, so that the traction effect of the blades is improved; a special suction channel is arranged in the forceps tube and used for sucking smoke, blood and interstitial fluid generated in the operation process.

The embodiment of the invention provides a multi-dimensional data processing method and system for intelligent scoring of emergency patients. The method comprises the following steps: acquiring dynamic temperature data and humidity fluctuation data of a burn wound surface through a flexible wearable monitoring device; inputting the time sequence change of the dynamic temperature data into a temperature-drug release model to generate drug concentration distribution; constructing an infection diffusion map taking the anatomical structure as a topological reference, wherein the infection diffusion map comprises an edge attribute representing the flow direction of tissue fluid and a node attribute representing a necrotic region; combining the metabolic rate parameter in the node attribute and the fluid resistance parameter in the edge attribute, iteratively updating the infection propagation intensity, and generating a weight distribution diagram; matching burn depth grading standards according to geometric deformation characteristics and gradient attenuation trends of the weight distribution map, and generating infection risk dynamic scores integrated with drug concentration distribution feedback. According to the technical scheme provided by the embodiment of the invention, the multi-dimensional data processing efficiency and precision can be improved.

The invention relates to the technical field of medical instruments, in particular to a cryoablation needle based on radio frequency rewarming, the medical instrument comprises a needle body, a capillary catheter, a first air inlet pipe, a second air inlet pipe, a needle tube, an insulating tube, a vacuum tube and a radio frequency welding wire, and after the needle body on the needle tube is led into tissue by an operator, the needle body is heated to be cooled; the tissue is frozen after air is injected through the first air inlet pipe and the second air inlet pipe to be cooled, then the tissue is rapidly heated under the action of the radio frequency welding line on the needle tube and is inactivated after multiple times of circulation, treatment is completed, meanwhile, internal redundant tissue fluid is automatically and rapidly guided out through the capillary catheter, secondary infection is avoided, and the device is simple in structure and convenient to operate. The problem of treatment of diseased tissues is effectively solved, and the device has good practicability and economical efficiency and is beneficial to popularization and use of equipment.

The utility model discloses a lung tumor sampling device, which belongs to the technical field of medical instruments and comprises an extraction tube used for extracting tumor tissue liquid, an input end of the extraction tube is provided with a suction needle head, a piston is connected in the extraction tube in a sliding mode, the upper end of the piston is connected with a push-pull rod, and the push-pull rod is connected with the suction needle head. The tumor tissue solid sampling device comprises an extraction tube and a suction needle head, the extraction tube is used for extracting tumor tissue solid, the sampling piece is used for extracting tumor tissue solid, the sampling piece, the extraction tube and the suction needle head are coaxially arranged, and the sampling piece comprises a connecting rod and a sampling needle connected with the end of the connecting rod. And more comprehensive and deep tumor information can be provided, so that the diagnosis accuracy can be improved.

The invention relates to the technical field of medical instruments, in particular to an ultrasonic endoscope biopsy instrument which comprises a handle mechanism, a needle tube, a needle core and a Luer seat. The needle tube is communicated with the Luer seat, a connecting cap is fixedly arranged at one end of the needle core, the connecting cap is movably matched with the Luer seat, and the needle core penetrates through the Luer seat and an inner cavity of the needle tube; an opening communicated with the outside is formed in the end, away from the Luer base, of the needle tube, a brush section is arranged at the end of the needle core, and a plurality of cell brushes are arranged along the brush section. In order to solve the technical problem that an existing ultrasonic biopsy sampling method has defects, when the ultrasonic biopsy sampling device is used, lesion tissue can be punctured through a needle tube to develop an activity channel for a needle core in the lesion tissue, and then the lesion tissue can be repeatedly rubbed by a cell brush in a manner of pushing and pulling a connecting cap, so that the lesion tissue can be conveniently sampled. More tissue fluid exudes from the lesion tissue or more tissue structures fall off, and the cell brush can be used for well collecting and sampling, so that enough lesion samples are collected to facilitate pathological analysis.

The prostate detection device comprises a top frame, a Y-axis electric air cylinder is embedded in an inner cavity of the top frame, a piston rod of the Y-axis electric air cylinder is fixedly connected with a support, a top barrel is transversely fixed to the top, close to an alarm lamp, of the support, and bottom covers are fixedly connected to the two sides, away from the top barrel, of the support; a sampling assembly for prostate tissue fluid puncture is arranged on the top cylinder, and a sample mixing assembly for uniformly mixing the prostate tissue fluid and a detection reagent is arranged on the bottom cover. Firstly, tissue fluid samples in prostate tissues and muscle tissues are punctured and sampled through the piston head, and after tissue fluid sampling work of prostate pathological samples is completed, the tissue fluid samples and detection reagents in the two groups of reaction barrels are fully and uniformly mixed and react, so that various substances in the tissue fluid samples are fully separated out; subsequent detection work such as direct smear microscopic examination, smear staining microscopic examination and tetrazole nitrogen blue test is facilitated, and the comprehensiveness and accuracy of prostate detection are improved.

The invention belongs to the technical field of electrochemical luminescence detection equipment, and particularly relates to a microneedle patch for wearable electrochemical luminescence sensing equipment and application of the microneedle patch. The microneedle patch comprises a microneedle base and a microneedle array, the microneedle base is divided into a left area, a middle area and a right area through two parallel grooves; the middle area is conductive and light-transmitting, and the left and right areas are conductive and light-proof; the microneedle arrays are arranged in the three areas and are all subjected to conductive treatment; the three areas are separated by grooves and are insulated from one another and are not conductive; and the surface in each area has conductive performance, so that electric signals can be conducted. The light-emitting sensing equipment takes the microneedle patch as a real-time acquisition tool of a tissue fluid sample, detects the concentration of cTnI in the tissue fluid on line, realizes real-time monitoring of a marker cTnI of myocardial injury and acute myocardial infarction in vivo, has the characteristics of high detection sensitivity, portability, simplicity in operation, low cost and the like, and realizes online in-situ monitoring of wearable electrochemical luminescence of a patient.

The invention discloses an electrochemical microneedle patch, a device and a method for detecting a physiological marker in skin tissue fluid. The electrochemical microneedle patch comprises a patch as well as a counter electrode, a reference electrode and a working electrode which are fixed on the patch; the counter electrode, the reference electrode and the working electrode are converged on one side of the patch in a printed circuit mode to form a signal connecting port, and each of the counter electrode, the reference electrode and the working electrode comprises at least one conductive microneedle electrode; each conductive microneedle electrode is long enough to penetrate through the epidermal layer of the skin and reach the corium layer, the conductive microneedle electrode of the working electrode is provided with a detection component for detecting a physiological marker in skin tissue fluid, and the outer surface of the conductive microneedle electrode is covered with a hydrogel layer; the hydrogel layer has a net-shaped structure which can form a swelling layer without dissolution after absorbing skin tissue fluid in the corium layer, and the net-shaped structure allows the to-be-detected physiological marker to diffuse into or move away from the surface of the working electrode. According to the invention, the stability of the current signal can be improved, the problems of signal distortion and instability and the like are reduced, and the method is suitable for long-time online detection.

The invention discloses a blood glucose monitoring device and method.The blood glucose monitoring device is characterized in that an interstitial fluid gathering module in the device is connected between a control module and a first sensor and used for gathering subcutaneous tissue fluid under the control of the control module, and the first sensor is used for generating electrochemical reaction with the skin surface of the gathered subcutaneous tissue fluid to output first current; the second sensor is connected with the reference electrode and used for generating electrochemical reaction with the skin surface attached to the reference electrode to output a second current, and the first voltage detection module is connected between the first sensor and the control module and used for monitoring a first voltage value of the first current and sending the first voltage value to the control module; the second voltage detection module is connected between the second sensor and the control module and used for monitoring a second voltage value of the second current and sending the second voltage value to the control module, and the control module is used for obtaining a blood glucose concentration value according to the first voltage value and the second voltage value.

The invention discloses a coronary plaque biomechanical property calculation method, and belongs to the field of computational biofluid mechanics in biomedical engineering. According to the method, the influence of cardiac pulsation, coronary blood vessel complex geometric distribution characteristics and coronary plaque composition factors is integrally considered, and the coronary plaque biomechanical characteristics are calculated; wherein the number of the fluid computational domains is two, and the two fluid computational domains are respectively a coronary vessel intracavity blood flow area and a plaque tissue fluid flow area surrounded by a fibrous membrane and a blood vessel; the two structural computational domains are respectively an elastic blood vessel wall and an ultrathin flexible plaque fiber membrane; the plaque fiber membrane generates deformation movement under the pressure of blood in blood vessels on two sides and tissue fluid in the plaque; the motion of the coronary plaque fibrous membrane is described by adopting an independently researched and developed immersion film method, and compared with a traditional coronary plaque biomechanical characteristic calculation method, the method has better information integrity, better accuracy and wider applicability.

A tissue graft for soft tissue repair or reconstruction comprising a sheet of a biopolymer-based matrix having a plurality of small perforations and a plurality of large perforations. The small perforations are sized to facilitate clotting and granulation tissue development within the perforations which, in turn, facilitates revascularization and cell repopulation in the patient. The large perforations are sized to reduce the occurrence of clotting and granulation tissue development within the perforations so that extravascular tissue fluids accumulating at the implant site can drain through the tissue graft. The large perforations enhance mammal tissue anchoring by permitting mammal tissue to compress into the perforations increasing mammal tissue contact area.

A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.

The present invention belongs to the field of biological detection technology, and specifically relates to a monkey high-mobility group protein B1 monoclonal antibody, an enzyme-linked immunosorbent assay kit and its application. Named HMGB1-11, it includes a heavy chain variable region and a light chain variable region; the heavy chain variable region has three complementary determining regions CDR-H1 to CDR-H3, and the amino acid sequences are shown in SEQ ID NO.6-SEQ ID NO.8; the light chain variable region has three complementary determining regions CDR-L1 to CDR-L3, and the amino acid sequences are shown in SEQ ID NO.9-SEQ ID NO.11. The monoclonal antibody of the present invention can specifically bind to monkey high-mobility group protein B1, and the monoclonal antibody can be paired with a monoclonal antibody after screening. Based on the monoclonal antibody combination, a monkey high-mobility group protein B1 enzyme-linked immunosorbent assay kit is constructed, which can detect the content of monkey high-mobility group protein B1 in monkey serum, plasma or tissue fluid.

The invention provides a preparation method of gas-jet mineralized collagen-hydrogel microspheres, and relates to the technical field of biological materials, and the preparation method comprises the following steps: dissolving collagen in a phosphate solution, dropwise adding the phosphate solution and a CaCl2 solution into a continuously stirred alkaline solution together, reacting for 12-48 hours, centrifugally collecting a precipitate, washing with water, centrifuging, and freeze-drying to obtain mineralized collagen; the method comprises the following steps: dissolving mineralized collagen and sodium alginate in deionized water, spraying the solution into a CaCl2 solution through a gas spraying spinning head by adopting a gas spraying technology, collecting microspheres, and repeatedly cleaning by adopting deionized water to obtain the gas spraying mineralized collagen-hydrogel microspheres. Mineralized collagen is encapsulated and loaded through microspheres, so that interferences of tissue fluid are isolated, and non-specific aggregation is reduced; optimizing the ratio of mineralized collagen, and directionally inducing stem cells to differentiate; the diameter of the microsphere is accurately controlled by regulating and controlling gas injection parameters to adapt to different wounds; active ingredients are controlled according to needs through a microsphere cross-linked network, and the multi-stage requirements of subcutaneous repair are met.

The invention provides a non-invasive tissue fluid lactic acid dynamic monitoring method. The method comprises the following steps: establishing a relation model of epidermal and subcutaneous lactic acid concentrations; steady-state current values under different epidermal lactic acid concentrations are obtained through in-vitro experiments, and then the function relation between the steady-state current values and the epidermal lactic acid concentrations is obtained; net current values under different subcutaneous lactic acid concentrations are obtained through human body experiments, a function relationship between the net current values and the subcutaneous lactic acid concentrations is established, and the function relationship can be used for a subsequent transdermal extraction detection process; substituting the measured epidermal lactic acid concentration into a relation model of epidermal and subcutaneous lactic acid concentrations to obtain an accurate concentration value of tissue fluid lactic acid monitoring; according to the method, in the dynamic real-time monitoring process of the lactic acid concentration of the tissue fluid, the concentration of the lactic acid extracted from the epidermis measured by the lactic acid sensor can be converted into the real-time and accurate lactic acid concentration of the subcutaneous tissue fluid, and rapid, painless, infection-free and continuous monitoring of the lactic acid level of the subcutaneous tissue fluid can be achieved.

The invention discloses a neurosurgery interventional therapy implantation dosing device, and belongs to the field of medical instruments, the neurosurgery interventional therapy implantation dosing device comprises an injection seat, the injection seat is provided with a first storage cavity for storing liquid medicine, the injection seat is provided with a catheter communicated with the first storage cavity, and the injection seat is fixedly provided with a first silica gel pad; the injection seat is provided with a flow guide assembly, the flow guide assembly is used for collecting tissue fluid generated by body rejection, the injection mechanism is fixed on an arm of a patient through a binding assembly, the injection mechanism is matched with the driving mechanism to add a medicament into the injection seat, and a flow guide groove in the outer wall of the injection seat guides the peripheral tissue fluid to flow. The supporting net facilitates the tissue fluid to enter the second storage cavity along the flow guide grooves, the arc-shaped plates in the second storage cavity are matched with the flow guide holes in the arc-shaped plates, the tissue fluid smoothly flows into the second storage cavity, and the structure constructs an efficient drainage path to efficiently collect the tissue fluid.

The application discloses a bladder tumor specimen extractor which comprises an adjusting transmission assembly capable of controlling preliminary cutting, a separating assembly capable of separating a tissue part and a liquid part of the bladder tumor and an operating handle. The application belongs to the technical field of bladder tumor surgery. When the bladder tumor temporarily stays on a tissue liquid passing layer, the removed bladder tumor can be punctured by a plurality of groups of puncture heads, so that the tissue part of the bladder tumor is blocked by the tissue liquid passing layer, and the tissue liquid and the plasma part of the bladder tumor can pass through the tissue liquid passing layer and enter a liquid storage bag. After sampling is completed, medical staff can take out the liquid storage bag to sample the tissue liquid and the plasma part of the bladder tumor, and the tissue part of the bladder tumor can be sampled from the tissue liquid passing layer. The application provides a brand-new bladder tumor sampling experience, greatly reduces the possibility of tissue liquid and plasma remaining in the bladder and brings convenience to medical staff.

The invention discloses a subcutaneous drug delivery device based on the interstitial fluid ebb-flow principle, and relates to the technical field of medical instruments, the subcutaneous drug delivery device comprises a syringe and a microneedle body, a partition plate is fixed in the syringe, and an injection piston driven by an automatic pushing mechanism to move is arranged below the partition plate; the microneedle bodies are distributed on the supporting pad in an array mode, the threaded pipe is driven by rotating the medicine feeding cavity, and therefore the microneedle bodies distributed on the supporting pad in the array mode can be driven to freely adjust the extending length and penetrate into the subcutaneous part of a patient by a proper depth, and the microneedle bodies can be used for conducting subcutaneous treatment on the patient in the mode that the microneedle bodies penetrate into the subcutaneous part of the patient. According to the invention, the medicine is uniformly spread in the subcutaneous tissue of a patient based on the principle of tissue fluid ebb-flow, so that the absorption effect of the medicine can be ensured, the pain and local tissue damage of the patient are not easily caused, and the experience feeling of the patient is improved; the liquid medicine in the syringe is automatically injected into the subcutaneous part of a patient through the microneedle body, so that the flow rate of the liquid medicine can be accurately controlled.

The application discloses a kind of lymphedema wearable type baking therapy drainage devices, including pressure sleeve, pressure sleeve includes multiple independent control outer layer air bag and multiple independent control inner layer air bag, outer layer air bag and inner layer air bag staggered arrangement and along the axial distribution of limb;Each outer layer air bag and each inner layer air bag independent control, along the direction of far end to near end, in turn, air bag is inflated and deflated control, to complete a cycle air bag progressive drainage pressurization.The pressure sleeve of the application has double-layer air bag, each air bag is independently controlled, and can extrude tissue fluid from far end to near end, so that tissue fluid moves to near end, and pushes and extrudes tissue fluid from limb to trunk direction.Because inner layer air bag and outer layer air bag are staggered arrangement, can avoid effusion to remain in the gap of adjacent annular air bag;The pressure sleeve of the application is provided with inner support tube, and forms circumferential block.

The microneedle diagnosis and treatment device comprises a sensing microneedle, a photo-thermal microneedle, a light source module, an electrochemical sensing module, a main control module and an upper computer, the sensing microneedle and the photo-thermal microneedle are respectively and electrically connected with the electrochemical sensing module, the light source module and the electrochemical sensing module are respectively and electrically connected with the main control module, and the main control module is in communication connection with the upper computer. The sensing microneedle disclosed by the invention is matched with the electrochemical sensing module and the main control module, so that the change of the glucose level in joint tissue fluid can be monitored in real time, and monitored data is transmitted to an upper computer through the main control module; a user can utilize the host computer to cooperate with the master control module to control the operation of the light source module, so that the photo-thermal microneedle absorbs light energy and generates high temperature, thereby inhibiting synovial hyperplasia of tissue fluid and achieving the purpose of integration of monitoring and treatment, the structure is simple, and closed-loop management of monitoring-evaluation-treatment can be realized.

The invention relates to the technical field of biological materials, and provides an absorbable self-repairing suture line for maintaining the stability of a mechanical biological microenvironment and a preparation method of the absorbable self-repairing suture line. According to the suture line, an absorbable high polymer material is adopted as a matrix, and PLA microcapsules containing a medical-grade cyanoacrylate n-octyl ester repairing agent are uniformly dispersed in the matrix through a melt blending spinning process. When the suture line generates microcracks at dynamic tissue parts such as cardiovascular and digestive tracts due to periodic stress, the stress at the tip of the cracks enables the microcapsules to be broken to release the repairing agent, rapid in-situ polymerization occurs under triggering of tissue fluid, the self-repairing efficiency of 90% or above is achieved, and the strength retention rate of 95% or above is maintained in the key rehabilitation period of the suture line. The defect that a traditional absorbable suture line is prone to fatigue fracture in a dynamic environment is overcome, the mechanical integrity is actively maintained through an intelligent self-repairing mechanism, all components can be completely degraded and absorbed, and a safer and more reliable solution is provided for dynamic tissue repairing.

The invention discloses an enzyme electrode method efficient blood glucose measuring device for real-time monitoring of diabetes, and relates to the technical field of blood glucose detection. The enzyme electrode method efficient blood glucose measuring device for real-time monitoring of diabetes mellitus comprises a detection box main body, a detection cavity is formed in the detection box main body, a detection opening used for stretching of the arm of a patient is formed in one side of the detection box main body, and a placement module is arranged in the detection cavity and used for bearing the arm, stretching into the detection opening, of the patient; a pressing limiting structure is arranged at the upper end of the placement module, and the bottom of the detection box main body is hollow and is provided with a supporting unit capable of being quickly opened and closed. According to the blood glucose measuring device, the blood sampling mode of the vein blood vessel of the arm of a patient is adopted to replace fingertip blood sampling, blood sampling obtained through fingertip blood sampling is capillary whole blood and contains tissue fluid, the measuring result is lower than the actual value, and the effect of venous blood sampled through the vein blood vessel is more accurate; the system is more suitable for real-time monitoring of patients in daily life.

This utility model relates to the field of blood sampling technology, specifically to a medical blood sampling device, comprising: a base plate, on which a support frame is fixedly mounted; and a driving assembly, which includes a rotating wheel disposed above the base plate and on one side of the support frame, with multiple collection cylinders slidably mounted in a circumferential array inside the rotating wheel. Through the design of the collection assembly, during blood sampling after a patient's finger is punctured, a rubber column can be used to squeeze and rub the sides of the fingertip, accelerating the flow of blood from the puncture point and dripping blood containing tissue fluid. The roller design allows for the enlargement of the roller diameter after the first drop of blood containing tissue fluid drips from the puncture point, lifting the finger and facilitating subsequent sampling. The dripped blood can be collected through the collection cylinders, preventing it from dripping to other places and causing inconvenience for subsequent cleaning.

The invention discloses an electrochemical microneedle biosensor and a preparation method thereof. The biosensor is a three-electrode system, comprising a working electrode, a counter electrode and a reference electrode, wherein the substrate materials of the three electrodes are all silicon-based high-density microneedle arrays; wherein the working electrode is a silicon-based high-density microneedle with a sputtered gold layer, gold nanoparticles with a dendrite structure are deposited on the surface, and a carcinoembryonic antigen (CEA) aptamer with high specificity is combined through an Au-S bond; the electrochemical microneedle biosensor provided by the invention adopts a high-density silicon-based microneedle array to construct a three-electrode system to detect carcinoembryonic antigen in tissue fluid, the working electrode has gold nanoparticles with a dendrite structure, and the active surface area is preferably increased, the patch-type structure with three electrodes in one is easy to operate, can realize non-invasive rapid detection, and has high detection sensitivity, good specificity and low detection limit, thereby providing a simple and quick method for detecting tumor biomarkers such as carcinoembryonic antigen.

The invention discloses a rice leaf disease identification sampler, and belongs to the technical field of plant sampling. The rice leaf disease recognition sampler comprises a reciprocating mechanism and a first cutter, and further comprises a second cutter which is of a polygon prism structure, and when the reciprocating mechanism drives the first cutter to move towards one side close to the second cutter, a cutting edge of the first cutter can be attached to the side wall, close to one side of the first cutter, of the second cutter; the intermittent rotating mechanism is used for driving the second cutter to rotate until the next side wall of the second cutter faces the first cutter when the cutting edge of the first cutter is separated from the side wall of the second cutter; the brushing mechanism comprises a first brush and a disinfectant spraying part, and the disinfectant spraying part is used for spraying disinfectant to the first brush. The rice leaf disease identification sampler can prevent tissue fluid or cell fluid of diseased leaves from remaining on the cutting knife when sampling the diseased leaves of rice, thereby preventing rice viruses from forming cross infection among different kinds of rice.

The utility model discloses skin vesicle tissue fluid suction equipment, which relates to the technical field of medical instruments, and comprises a needle cylinder, a needle head and a cavity, and further comprises a piston arranged in the cavity, and a connecting rod is fixedly arranged at the upper end of the piston; a second inclined groove is formed in the peripheral surface of the driven rod; the top of the driving rod is located outside the needle cylinder, a containing cavity is formed in the driving rod, and a first inclined groove is formed in the peripheral face of the driving rod; and the reverse structure is connected with the driving rod and the driven rod, and when the driving rod moves downwards, the driven rod can be driven to move upwards through the reverse structure. The driven rod can be driven to move upwards through the reverse structure, suction operation can be completed only by holding the needle cylinder with four fingers and pressing the driving rod with the thumb, the device does not need to be stabilized with the other hand, and use is more convenient.