603 results about "Tissue fluid" patented technology

The present invention relates generally to a non-invasive method and apparatus for measuring a fluid analyte, particularly relating to glucose or alcohol contained in blood or tissue, utilizing spectroscopic methods. More particularly, the method and apparatus incorporate means for detecting and quantifying changes in the concentration of specific analytes in tissue fluid. Also, the method and apparatus can be used to predict future levels of analyte concentration either in the tissue fluid or in blood in an adjacent vascular system.

A sectional cassette (10) for use in a process for harvesting and handling tissue samples for biopsy analysis is disclosed. In the procedure, a tissue biopsy sample is placed on a tissue trapping supporting material (A′) that can withstand tissue preparation procedures, and which can be cut with a microtome. The tissue is immobilized on the material, and the material and the tissue are held in the cassette (10) subjected to a process for replacing tissue fluids with wax. The tissue and supporting material are sliced for mounting on slides using a microtome. Harvesting devices and containers (200) using the filter material (202) are disclosed. An automated process is also disclosed.

An apparatus for detection and quantitation of an electrochemically-detectable analyte, such as glucose, in blood or interstitial fluid includes a meter unit, a lancet and an electrochemical sensor. Of these components, the meter is preferably reusable, while the lancet and the electrochemical sensor are preferably incorporated in assemblies intended for single-use. The meter unit has a housing, within which a lancet is engaged with a mechanism for moving then lancet; a connector disposed within the housing for engaging an electrochemical sensor specific for the analyte and transmitting a signal indicative of the amount of analyte, and a display operatively-associated with a connector for displaying the amount of the analyte to user. The electrochemical sensor is adapted for detection of a particular analyte. In addition, the electrochemical sensor has an absorptive member for uptake of a sample of blood or interstitial fluid. In one version, the lancet moves from a initial position to a piercing position in which skin of the user is pierced and optionally back to a retracted position. The electrochemical sensor is disposed such that the absorptive member takes up a sample from the pierced skin of the user when it is pierced by the lancet without movement of the apparatus. In an alternative version, the lancet is a hollow cannula through which blood or interstitial fluid is transported from the puncture site to an absorbent portion of the electrochemical sensor. In either version, the apparatus provides single-step operation in which sample acquisition and analysis occur as a result of the single action of pressing, the apparatus against the users skin.

A sectionable cassette for use in a process for harvesting and handling tissue samples for biopsy analysis is disclosed. In the procedure, a tissue biopsy sample is placed on a tissue trapping and supporting material that can withstand tissue preparation procedures and which can be cut with a microtome. The tissue is immobilized on the material and the material and the tissue are held in the cassette and are subjected to a process for replacing tissue fluids with wax, and then the tissue and the supporting material are sliced for mounting on slides using a microtome. Harvesting devices and containers using the filter material are disclosed. An automated process is also disclosed. One embodiment has the tissue trapping and supporting material porous and another embodiment includes a tissue supporting material that is not easily microtomed.

The invention relates to a modified starch material for biocompatible hemostasis, biocompatible anti-adhesion, tissue healing promotion, absorbable surgery sealing and tissue adhesion. The invention applies biocompatible modified starch to animal tissues, wherein the modified starch material has the molecular weight of more than 15,000 daltons, and the particle diameter of between 1 and 1,000 mu m. The modified starch hemostatic material has stypticity, reduces hemorrhage, blood oozing and tissue fluid oozing of wounds, maintains relative moistening or drying of wound surfaces or the wounds, inhibits bacterium growth and inflammation reaction, and contributes to locally diminish inflammation of the wounds and relieve pain of patients. Moreover, the modified starch material can wash local parts after operation is over and remove redundant modified starch which does not participate in hemostasis, and can easily remove haemostatic under the condition of debridement treatment after self-help and first-aid treatment of war wounds; and hemostatic materials with a small amount of modified starch can be absorbed by the body, so that the pain of tearing of gauzes and bandages on people is avoided.

A method for monitoring thoracic tissue. The method comprises intercepting reflections of electromagnetic (EM) radiation reflected from thoracic tissue of a patient in radiation sessions during a period of at least 24 hours, detecting a change of a dielectric coefficient of the thoracic tissue by analyzing respective the reflections, and outputting a notification indicating the change. The reflections are changed as an outcome of thoracic movements which occur during the period.

A demineralized bone putty composition comprises: (1) demineralized bone matrix (DBM); and (2) a lipid fraction selected from the group consisting of lecithin and a mixture of lecithin and triglycerides containing unsaturated fatty acids. The putty composition is moldable, biocompatible, slowly resorbable, and soluble in tissue fluids, and non-extrudable. The composition delivers a biologically active product to animals and humans that will enhance bone formation at sites where bone is lost, deficient, or present in suboptimal amounts. The composition can further comprise calcium, an antioxidant such as Vitamin E or Vitamin C, or a hydrophilic polymer such as methylcellulose or hydroxypropyl methylcellulose.

The corneal implant of the current invention takes the general form of a thin, transparent, flexible, porous, biocompatible film of suitable polymer material. The implant is sufficiently porous, the porosity being imparted by the film being irradiated to produce tracks and the material in those tracks being subsequently removed through an etching process, to allow the adequate flow of gaseous and tissue fluid components through the film. Specific embodiments of the invention are achieved by the addition of features to the general form. The embodiment applicable to corneal reshaping features a surface relief pattern in the implant. The artificial iris embodiment features an imprinted partly to fully opaque or partially reflective annular iris pattern of selected inner and outer diameters.

A novel modified matrix system, mimicking a metastatic environment, that can be used to capture and detect viable cancer and normal cells from tissue fluid samples derived from cancer subjects and which provides effective cell separation for diagnostic and therapeutic applications in treating patients with metastatic diseases.

Compositions which self-assemble under physiological conditions are formulated for application to wounds. The formulations include a pharmaceutically acceptable carrier or are provided as part of a medical device or coating. The formulations may also include other therapeutic, prophylactic or diagnostic agents. The formulation can be administered as appropriate for treatment of one or more disorders or conditions. For example, the formulation may be applied to repair an injury or during surgery of the lung, eye or dura, or following an epidural or spinal tap, to stop leakage of blood, interstitial fluid, or cerebrospinal fluid. The formulation may be administered to a burn or ulcer. The formulation may be dispersed in a suture or adhesive for administration at the time of or as released following suturing or gluing of a wound, thereby limiting bleeding, loss of tissue fluids, or other fluids such as those produced by parenchymal tissues such as the liver, pancreas, and gastrointestinal tract. The formulation may be applied to any site of bleeding, in a bandage, gauze, sponge, or other material, for immediate control of bleeding, or released later to control bleeding if the initial treatment such as suturing or pressure is insufficient. In one embodiment, the formulation is provided as a dry or lyophilized powder. In another embodiment, the material is provided in water. In another embodiment, the material is provided in combination with an oil and forms a laminate. In another embodiment, the formulation is provided as a coating on a device, for example a stent or a catheter. The material is also useful to isolate tissue, for preservation of tissue for subsequent transplantation or reattachment, and as a bulking, stabilizing or hydrating agent.

In the present invention, a biodegradable bone graft is disclosed, which includes: a scaffold made of a biodegradable material; and a collagen-embedding matrix portion which completely encompasses the scaffold. The above-mentioned bone graft can increase the micro-porosity of the scaffold to enable cells to grow adhesively thereon. Compared with the scaffold only, the above-mentioned bone graft has high hydrophilicity. Hence, the bone graft of the present invention can efficiently retain tissue fluid, cell growth factors, blood and / or bone marrow which are mixed with the bone graft beforehand to achieve osteoinduction. Furthermore, the collagen-embedding matrix portion can also serve as a carrier to encompass other bone graft materials and drug molecules. The present invention also relates to a method for manufacturing the above-mentioned bone graft.

The invention relates to a hollow or solid fibre having multiple porous layers concentrically arranged, and wherein at least one of the layers comprises functionalized or active particles that are well accessible and maintain their function after preparation. The layer containing high loads of particles can be either the outer or the inner layer. The main function of the other porous layer is to provide mechanical stability to the fibre. It can further act as a sieve and prevent unwanted compounds or species to come in contact with the functionalized particulate matter. Where it is the inner layer, the second layer can advantageously be a biocompatible material. With the second being the outer layer it is now possible to reach a particle content of 100 wt % in the inner layer. These fibres comprising high densities of functionalized particulate matter and of still sufficient mechanical strength can be used for (selective) adsorption, conversion, isolation or purification of compounds from a mixture of compounds, in particular from a fermentation broth, tissue broth, plant broth, cell broth or blood.

A method of making injection molded microstructured articles for drug delivery and tissue fluid sampling by injection molding the articles onto a carrier web to then convey the articles during the manufacturing process. The molded articles are attached to the web by closing the mold over a portion of the web prior to injection. This is particularly beneficial where the article has a highly sensitive surface, such as an array of delicate microneedles for drug delivery or fluid sampling. It also facilitates subsequent processing, which may include applying drug coatings and other processing.

The invention discloses a microneedle transdermal drug delivery paste for treating rheumatoid arthritis. The microneedle transdermal drug delivery paste comprises a base layer, and a plurality of microneedles, wherein the microneedles are vertically fixed on the surface of the base layer and are arranged at intervals mutually; the microneedles are provided with active medicine components. In treatment, the microneedles puncture through skin cuticle and enter epidermis, and then medicines stored in the microneedles can be released into tissue fluids, so that the purpose of treatment is achieved, defects that a conventional transdermal drug delivery preparation has difficulties in breaking through natural barriers of cuticle and is low in biological utilization rate can be overcome, and thetransdermal drug delivery rate of medicines can be greatly increased. The dissoluble microneedle paste comprises one or more active medicinal components for treating rheumatoid arthritis, and meanwhile a synergetic effect can be taken into play; due to puncture functions of the microneedles, auxiliary treatment can also be achieved. The invention further provides a preparation method of the microneedle transdermal drug delivery paste. By adopting the preparation method, medicines of different types of dissolubility can be carried by one same dissoluble microneedle paste, and multiple medicinescan be also carried to achieve synergetic drug delivery treatment.

The invention discloses a 3D printing bionic porous biological ceramic artificial bone and a preparation method thereof. A porous biological ceramic artificial bone model is designed through a TPMS and CSG combined method, slurry capable of being used for printing is prepared through biological ceramic powder and a binding agent, macropores and micropores are distributed in the porous biological ceramic artificial bone prepared through the combination with the 3D filament-free printing process, the pore diameter of the micropores is smaller than 100 micrometers, the pore diameter of the macropores is 200-800 micrometers, the total porosity is 20% to 80%, the communicating rate between the macropores is not lower than 99%, precise design of porosity, communication and homogeneity in the artificial bone is achieved, and meanwhile good pore communication is ensured. Adopted raw materials have good biocompatibility, entry passageways of cells and tissue fluid are provided by the macropores, the micropores can better adsorb tissue fluid nearby for cell growth, the cell growth speed and the new bone generation speed can be increased by combining the micropores with the marcropores, and application of the porous biological ceramic artificial bone in human body large bone defect repair clinic treatment is facilitated.

The invention discloses an implantable human blood glucose concentration continuous monitoring system based on optical fiber attenuation total reflection, consisting of double optical paths and comprising a light source, an attenuator, a spectroscope, an optical fiber coupling device, an optical fiber ATR sensor, a measurement photodetector, a reference photodetector, a data collection system anda computer, wherein after being attenuated by the attenuator, the light source is divided into two optical paths formed by a measurement light and a reference light; in one optical path, the measurement light enters the optical fiber ATR sensor in a coupling way through a coupling method by the optical fiber coupling device and is received by the measurement photodetector via a transmission lightof the optical fiber ATR sensor; in the other optical path, the reference light is directly received by the reference photodetector; signals recevied by the measurement photodetector and the reference photodetector are synchronously collected by the data collection system, are sent to the computer and are in analysis treatment, and the computer displays a measurement result and is also connected with the light source. The invention adopts a direct measurement in vivo method to directly measure the glucose concentration in a tissue fluid, thereby avoiding an error of measurement in vitro.

A solid pharmaceutical composition for parenteral administration having an inner matrix containing at least one therapeutic agent, and a biodegradable, and water-impermeable coating covering part of the surface of said composition. The inner matrix disintegrates upon contact with animal tissue or tissue fluids. By providing a disintegratable and / or soluble inner matrix comprising the drug with a water-impermeable coating covering part of the surface of said composition, the rate of release of the drug can be controlled. The specific rate of release can be controlled by carefully designing the part of the surface which is not covered.

The invention discloses a human glucose concentration continuous monitoring device based on optical fiber surface plasmon resonance. An optical fiber SPR (Surface Plasmon Resonance) probe is implanted in a human body; light emitted by a light source reaches the optical fiber SPR probe via an optical fiber coupler; after SPR attenuation, reflected light reaches a spectrograph through the optical fiber coupler; and a computer analyzes and processes data output by the spectrograph and displays monitoring results. A micro-cavity is fixed outside the optical fiber SPR probe, one side of the micro-cavity is a semitransparent film, and only glucose and other micromolecules can enter the micro-cavity. GGBP proteins or borate polymers are fixed on the goldfilm surface of the optical fiber SPR probe and can carry out specificity absorption to the glucose molecules, thereby improving the measurement sensitivity. The invention can realize human glucose concentration continuous monitoring by measuring the glucose concentration of human body tissue fluid, has high measurement precision and good stability and can realize 24-hour human glucose concentration continuous monitoring and provide comprehensive glucose concentration change data for better guiding the diabetes treatment.

A biodegradable implant and a method for manufacturing one. The implant comprises a matrix component containing at least one biodegradable polymer or copolymer and a pyrrolidone plasticizer that is adapted to reduce the rigidity of the implant. The plasticizer substantially exits from the implant after coming into contact with tissue fluids of the organ system in such a manner that the bending resistance of the implant prior to the insertion of the implant into the organ system is lower than after its insertion into the organ system.

The present invention relates generally to a non-invasive method and apparatus for measuring a fluid analyte, particularly relating to glucose or alcohol contained in blood or tissue, utilizing spectroscopic methods. More particularly, the method and apparatus incorporate means for detecting and quantifying changes in the concentration of specific analytes in tissue fluid. Also, the method and apparatus can be used to predict future levels of analyte concentration either in the tissue fluid or in blood in an adjacent vascular system.

A device is provided for transporting a tissue specimen without the risk of exposing health-care workers to potentially hazardous tissue fluids. The device includes a container, a flexible portion, a first support member received in the container, a second support member extending from the fist support member, a first locating indicia on a first side of the first supporting member, and a second substantially radiopaque locating indicia on a second side of the first support member, and an indicating member movably mounted on the first side of the first support member. The first support member has a first locating indicia on a first surface and a second locating indicia on a second surface, which generates a radiographic image when exposed to x-rays. The first and second indicia are substantially in registration such that when a tissue specimen is positioned on the first locating indicia and is then exposed to x-rays, a radiographic image of the specimen superimposed on the image of the second locating indicia is produced. Since both locating indicia are in registration, any tissue abnormality within the specimen can be precisely located with respect to both indicia. The device further includes a second support member, limiting contact of the container walls with the tissue specimen, and biasing the flexible portion away from the first support surface containing the tissue specimen. The device further includes an at least partially radiopaque indicating member for indicating the position of the tissue specimen on the radiographic image. A method for using the device to generate radiographic images of a tissue specimen is also disclosed.

The invention discloses a method for preparing a porous polymer micro needle by using a template method and an application thereof. The method comprises the following steps of: (1) dissolving a polymer and a template agent in a solvent to prepare a polymer solution; (2) filling the polymer solution into a micro needle mould; (3) removing the solvent in the obtained micro needle mould to obtain a solid micro needle; (4) removing the template agent in the obtained solid micro needle to obtain the porous polymer micro needle. By improving the overall process flow design of the preparation method,the method can solve the technical problems of a complex preparation process, harsh conditions, a complicated process, high price, difficult control of the pore structure and size, difficult large-scale production and application and the like of the porous polymer micro needle, the obtained porous polymer micro needle can be used for tissue fluid extraction and transdermal administration, such asskin tissue fluid and blood extraction and transdermal administration of proteins, polypeptides and small molecular drugs in cosmetic, hair growth, immunity, treatment and other applications.

The invention relates to a preparation method, a raw material, a product and an application of an optical coupling crosslinking hydrogel material. Component A-nitrobenzyl phototrigger modified high-molecular derivatives are dissolved in a medium with biological compatibility in order to obtain a solution A; component B-primary amine, diamine, hydrazide, hydroxylamine high-molecular derivatives aredissolved in a medium with biological compatibility in order to obtain a solution B; the solution A and the solution B are uniformly mixed in order to obtain a hydrogel precursor solution; the hydrogel precursor solution is under light source irradiation, aldehyde group or ketone group generated by nitrobenzyl in the component A and primary amine, diamine, hydrazide, hydroxylamine groups in the component B are crosslinked in form of Schiff base in order to form a hydrogel. The invention also provides a kit for preparation of the hydrogel, and applications of the hydrogel to tissue engineering, regenerative medicine, 3D printing, and carriers of cells, proteins or drugs. The hydrogel precursor solution is sprayed or smeared on the surface of tissue in order to realize in situ gelation under light, and the product is especially suitable for postoperative wound enclosing and tissue fluid leakage sealing.

The invention discloses a multi-channel nerve repair conduit with a tissue induced function and a mold; chitosan-coated salidroside microspheres and composite type salidroside slow-release microspheres are prepared, the drug cumulative release amount is calculated, the composite type salidroside slow-release microspheres with different contents are mixed with I-type collagen, and salidroside slow-release microspheres / I-type collagen is obtained; a multi-aperture cylindrical nerve conduit core layer is prepared by using the mold, a nano fiber nerve conduit shell layer is prepared by a high-pressure electrostatic spinning technology, the core layer and the shell layer are nested, and thus the multi-channel nerve repair conduit with the tissue induced function is prepared. The shell layer of the conduit has a good role in exchanging with a tissue fluid, and has a function of guiding nerve growth; the core layer has the functions of guiding nerve fiber orientation growth, promoting stem cells to directionally differentiate to schwann cells and accelerating the nerve fiber growth and function recovery, effectively repairs peripheral nerve defects, has good degradation and biocompatibility, and meets the requirements of a tissue engineering scaffold material.

The invention provides a preparation method of a duramater / spinal dural transplanting substitute which is obtained by repeated freezing and thawing of dural tissue, rolling and cracking of cells, crosslinking fixed protection, accellular antigen extraction, dense surface fibrosis modification, packaging and sterilization, and has the advantages of simple method, wide raw material sources, cheap raw materials, and low cost. The prepared dural substitute completely removes components of cells and other antigen components simultaneously when protecting dural tissue natural structure and properties, is good in biocompatibility, free of immune rejection, safe and reliable, good in mechanical performance, and easy in clinical operation, can meet the needs of defect repair, has the function of promoting tissue regeneration as a loose surface is beneficial to the tissue fluid adsorption, active factor enrichment, and growth of blood vessels and cells, and has the advantages of rapidness in fusion with a host, biodegradable absorption, and good repair effect. The animal test shows that the defect can be completely repaired without brain or spinal fluid leakage, or adhesion with brain tissue, and significant rejection is not found.

The present invention is to present an analyzer for analyzing a concentration of a predetermined component contained in tissue fluid of a subject, the analyzer being capable of mitigating the pain of the subject. The analyzer comprises: an extraction medium retainer for retaining an extraction medium for holding tissue fluid extracted through a skin of a subject; a component amount information obtainer for obtaining component amount information regarding amount of a predetermined component contained in the tissue fluid held in the extraction medium; an electrical information obtainer for obtaining electrical information related to amount of the extracted tissue fluid by supplying electrical power to the extraction medium which is holding the extracted tissue fluid; and a component concentration obtainer for obtaining a concentration of the predetermined component contained in body fluid of the subject based on the component amount information and the electrical information.

The invention discloses a method for synchronously analyzing a base, a nucleotide, an organic acid, a fatty acid, an amino acid and a saccharide metabolic product with a two-step derivation method. The method comprises the following steps of: performing a series of physicochemical method technical treatment such as ultrasonic treatment, centrifugation, oximation, urea removing, phosphorus removing, sulfur removing, protein removing, nitrogen blowing, vacuum drying, and trimethyl silylation derivation on biological substrate samples (such as urea, blood, cerebrospinal fluid, and tissue fluid); and detecting the biological substrate samples by adopting a gas chromatograph-mass spectrum combination technology. Due to the adoption of method, programmed treatment can be performed on the biological substrate samples simultaneously, and over 400 kinds of metabolic intermediate and final products of over five kinds of substances can be detected at one time.

The invention discloses a method for artificially culturing seawater anucleate pearl. The method comprises the following steps: taking out the mantle epithelium of a healthy nacre, removing the skirt band part, digesting the mantle epithelium in protease solution, then adding the culture solution with shell blood serum to stop the digestion, culturing the culture solution containing shell tissue fluid and a property amount of penicillin and streptomycin in a sterile environment for 5 to 30 hours, then injecting the cell suspension into a pearl breeding shell body, and putting the pearl breeding shell body in the seawater for suspended culture or into a culture pond box for feeding after a recreation period. The method has little damage to the pearl breeding shell, a high survival rate and a high pearl formation rate. The cultured pearl is suitable for medicinal use. The method has convenient operation and low cost.

The invention belongs to the technical field of non-woven fabrics, and relates to a three-layered composite chitin non-woven fabric, a preparation method thereof and an application thereof. The three-layered composite chitin non-woven fabric comprises a chitin fabric layer, an ES fabric layer, and a viscose fabric layer between the two. The chitin fabric layer, the ES fabric layer, and the viscose fabric layer are combined into an integral whole. The three-layered composite chitin non-woven fabric has advantages of good flexibility, good ventilating and moisturizing capacities, good haemostasis and tissue fluid absorption capacities, and ideal wound curing effect. Also, the fabric can be compactly applied on a wound. With the fabric, tissue fluid can be prevented from overflowing, and adhesion between a wounded area and the fiber can be avoided. With the method provided by the present invention, the preparation of the fiber can be achieved by a traditional non-woven machine, and no special apparatus is required. With the method, comprehensive embodiments of the technical effects of the three-layered composite chitin non-woven fabric can be ensured. According to the application provided by the present invention, the technical effects of the three-layered composite chitin non-woven fabric can be embodied in medical treatments.