31 results about "Coronary plaque" patented technology

The invention belongs to the technical field of medical imaging, and particularly relates to a method for predicting the growth of coronary atherosclerotic plaque. The method comprises the steps thatIVUS images and OCT images of at least two moments are segmented respectively, then the segmented IVUS images and OCT images are fused, a three-dimensional multi-modality fluid-solid coupling model with cyclic bending is established according to a fused contour, a mechanical result of the model is calculated, risk factors of mechanics and morphology are extracted in combination with a morphological result, a plaque growth indicator is given, and the growth of the plaque is predicted by using a machine learning method, thereby providing an accurate and reliable method for predicting the growthof coronary plaque. The method for predicting the growth of the coronary atherosclerotic plaque provides the possibility of clinical application for plaque growth prediction.

The invention belongs to the technical field of medical image processing and computer-aided diagnosis, and discloses a coronary plaque data detection method and system, a storage medium and a terminal. The method comprises steps: on a three-dimensional medical image, extracting a three-dimensional image block along a coronary center line point to serve as a sample, and dividing a sample data set;constructing a three-dimensional stepped convolutional neural network by taking the coronary artery three-dimensional image block sample as input and whether the image contains plaques or not as output; sending the training data set into a network, and calculating a loss function to train a network model; and predicting the trained network model on a test set to complete a coronary plaque detection task. Semi-supervised learning is performed in combination with unlabeled data, plaque detection is completed only depending on a small amount of labeled data, the labeling data difficulty is reduced, and the detection precision is improved. The coronary plaque detection method realizes coronary plaque detection, and has the characteristics of no need of blood vessel pre-segmentation, high accuracy and dependence on a small amount of annotation data.

Systems, methods and apparatus are provided through which coronary plaque is classified in an image and visually displayed using an iterative adaptive process, such as an expectation maximization process.

Systems and methods are disclosed for predicting coronary plaque vulnerability, using a computer system. One method includes acquiring anatomical image data of at least part of the patient vascular system; performing, using a processor, one or more image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical image data; predicting, using the processor, a coronary plaque vulnerability present in the patient's vascular system, wherein predicting the coronary plaque vulnerability includes calculating an adverse plaque characteristic based on results of the one or more of image characteristics analysis, geometrical analysis, computational fluid dynamics analysis, and structural mechanics analysis of the anatomical image data; and reporting, using the processor, the calculated adverse plaque characteristic.

The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and / or imaging and / or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and / or imaging and / or monitoring the presence of coronary plaque, carotid plaque, iliac / femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and / or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.

The present invention provides a high-dose vitamin D3 composition oral preparation and particularly a vitamin D3 oil preparation and a vitamin D3 soft capsule preparation. The dose range of the vitamin D3 is between 500 IU (12.5 [mu]g) and 50000 IU (1250 [mu]g). The high-dose vitamin D3 oral preparation is used for the treatment and prevention of vitamin D deficiency and osteoporosis, the fall prevention, and the treatments of depressions, hypertensions, metabolic syndromes, hyperlipidemia, and autoimmune diseases, and can also stabilize and reverse atherosclerosis and coronary plaque formation.

The invention relates to a patch segmentation method and device, computer equipment and a storage medium. A target coronary artery comprising a plurality of reference image blocks is collected, coronary artery plaque detection is performed on each reference image block in the target coronary artery through a preset plaque detection network, candidate reference image blocks are obtained, and then the obtained candidate reference image blocks are input into a preset plaque segmentation network to obtain he coronary plaque segmentation result of the candidate reference image block. According to the method, the recognition rate of coronary plaque detection can be improved, the edge detail segmentation of the coronary plaque can be more accurate, and the coronary plaque in each candidate reference image block can be quickly and accurately segmented.

The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and / or imaging and / or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and / or imaging and / or monitoring the presence of coronary plaque, carotid plaque, iliac / femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and / or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.

The embodiment of the invention discloses a plaque detection method and device, equipment and a medium. The method comprises the following steps: acquiring a to-be-detected coronary artery image sequence; generating at least one to-be-detected coronary artery image combination according to the to-be-detected coronary artery image sequence, wherein the to-be-detected coronary artery image combination comprises at least two to-be-detected coronary artery images; inputting the to-be-detected coronary artery image combination into a trained plaque detection model to obtain an intermediate plaque detection result of each to-be-detected coronary artery image; and determining a final plaque detection result based on the intermediate plaque detection result of each coronary artery image to be detected. According to the technical scheme, the problems that an existing coronary plaque detection technology is large in detection difficulty and inaccurate in detection are solved, and the effects ofreducing the coronary plaque detection difficulty and improving the plaque detection efficiency and accuracy are achieved.

In the methods of the invention, an agent that increases phagocytosis and / or efferocytosis of cellular components of coronary plaque is administered to the subject in a dose and for a period of time effective to stabilize, prevent or reduce aneurysm disease in the individual.

The invention discloses a multi-frequency three-dimensional coronary artery plaque detecting method.The multi-frequency three-dimensional coronary artery plaque detecting method comprises the steps that S1, two current emitting electrodes and two voltage detecting electrodes are arranged on an impedance catheter, and a same-current multi-frequency scanning method is adopted to measure the cross section of the inner cavity of a blood vessel to be detected; S2, voltage values of the required measurement positions in the blood vessel to be detected where the impedance catheter is located are respectively acquired at the same current and in a sweep frequency state; S3, the impedance catheter is driven to perform uniform motion, and voltage values of the impedance catheter in the motion process are acquired at the same current in multiple frequency period switching states; S4, the voltage values obtained in the multiple frequency period switching states, the cross sections of the positions of the blood vessel to be detected and conductance parameters corresponding to plaque loads are acquired; S5, a numerical calculation and numerical optimization combination method is adopted to calculate three-dimensional spatial distribution of the plaque parameters of the positions of the blood vessel to be detected, and the three-dimensional spatial distribution of the plaques in the blood vessel wall is further determined.The multi-frequency three-dimensional coronary artery plaque detecting method is more accurate than a traditional single-frequency method.

There is provided a system for cardiac electromagnetic / magnetic catheterization for diagnosing and treating blood vessels of a patient. The system having at least one electromagnetic intraluminal capsule able to force its way through a narrowing blood vessel, the capsule carrying a camera allowing visualization of blood vessels of a patient. There is a portable electromagnetic tip, where the tip pulls the electromagnetic capsule by electromagnetic force, and when the magnetic tip moves along a body of a patient and pulls the intraluminal electromagnetic capsule along with it towards a narrowing blood vessel visualized by the camera, so that the capsule then treats the narrowing site and clears the blood vessel from coronary plaque. In addition working capsule can replace diseased valve in any cardiac position for either temporary or permanent needs.

The invention provides a coronary artery plaque state evaluation method and device, electronic equipment and a computer readable storage medium. The coronary artery plaque state evaluation method comprises the following steps: step S1, providing an optical coherence tomography image of a coronary artery plaque to be evaluated; S2, identifying the optical coherence tomography image, and determining fiber components and lipid plaques; and S3, evaluating the state of the coronary plaque based on the fiber component and the lipid load of the lipid plaque. According to the coronary artery plaque state evaluation method, the tomographic image of the blood vessel to be evaluated is obtained through the optical coherence tomography technology, the fiber components and the lipid plaque in the tomographic image are recognized based on the obtained tomographic image, and the state of the coronary artery plaque is comprehensively evaluated based on the recognized fiber components and lipid size. Quantitative evaluation can be realized, and the repeatability is higher.

The invention discloses a simplified calculation method based on coronary artery multimode image crack formation and expansion and a plaque fracture risk quantification evaluation system, and the method comprises the steps: obtaining multimode images, such as coronary artery angiography images and intracavity images (such as optical coherence tomography), through an image input module; respectively segmenting and registering interested blood vessels or plaques on different images by adopting an image processing technology, and quantitatively obtaining anatomical indexes of lesion coronary plaques; and further calculating the distribution of the dynamic indexes of the superficial wall based on time sequence coronary angiography and determining a relatively high-risk position along the longitudinal direction of the blood vessel so as to obtain a fatigue risk coefficient formed by the local crack of the superficial wall. According to the method, the anatomical indexes of the coronary artery multi-modal image are combined, and the quantitative assessment of the crack formation based on the superficial surface of the coronary artery and the plaque crack propagation risk based on the cross section image are further added, so that the plaque fracture process is assessed more completely and comprehensively.

Systems, methods and apparatus are provided through which coronary plaque is classified in an image and visually displayed using an iterative adaptive process, such as an expectation maximization process.

The invention belongs to the field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for treating coronary heart disease as well as a preparation method and application thereof. The traditional Chinese medicine composition for treating the coronary heart disease comprises the following raw materials of radix astragali, teasel, rhizoma cyperi, radix curcumae, rhizome ligustici wallichii, fructus trichosanthis, pericarpium citri reticulatae, ginger processed pinellia, poria cocos, bulbus fritillariae thunbergii, loofah sponge, caulis lonicerae, cortex cinnamomi and unprocessed radix glycyrrhizae. The traditional Chinese medicine composition provided by the invention is accurate in syndrome differentiation and focuses on pathogenesis, and a patient is stable in illness state after being treated with traditional Chinese medicine or combination of traditional Chinese medicine and western medicine; the technical effects of stabilizing coronary artery lesions, controlling blood fat, blood pressure and blood sugar stably and even reducing blood fat, blood pressure and blood sugar can be effectively achieved; the traditional Chinese medicine composition assists in controlling cardiovascular risk factors and stabilizing coronary plaques, and has a treatment effect of reversing the plaques after being taken for a long time; and the symptoms of chest distress and breath shortness are relieved.

The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and / or imaging and / or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and / or imaging and / or monitoring the presence of coronary plaque, carotid plaque, iliac / femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and / or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.

The present disclosure is directed to compounds, diagnostic agents, and related methods. In some cases, methods for treating patients are provided. More specifically, the disclosure provides compounds, diagnostic agents, and kits for detecting and / or imaging and / or monitoring elastin rich tissues. In addition, the disclosure provides methods of detecting and / or imaging and / or monitoring the presence of coronary plaque, carotid plaque, iliac / femoral plaque, aortic plaque, renal artery plaque, plaque of any arterial vessel, aneurism, vasculitis, other diseases of the arterial wall, and / or damage or structural changes in ligaments, uterus, lungs or skin, as indicated by changes in total vessel wall area, internal lumen size, and exterior arterial perimeter.

The invention provides application of a reagent in the preparation of a kit; the kit is used for diagnosing acute coronary syndrome; the reagent is used for detecting at least one of miR-155-5p, miR-483-5p, and miR-451a. The inventor discovers through experiments that miR-155-5p, miR-483-5p or miR-451a has significant expression differences before and after plaque rapture, and has good diagnostic value in the early diagnosis for the rapture of coronary plaque; the kit prepared with the reagent for detecting at least one of miR-155-5p, miR-483-5p, and miR-451a is effectively applicable to the early diagnosis of the rupture of coronary plaque, and has the advantages of high sensitivity and high specificity.

The invention discloses a nano magnetic material for treating atherosclerosis, and a preparation method of the nano magnetic material. The preparation method comprises the following steps: preparing superparamagnetic nano Fe3O4 by utilizing a biomass material, wherein the surface is modified by ICG and polyethylene glycol; and injecting the prepared nano magnetic material into a human body, aiming, accumulating in lipid-rich coronary plaques, and irradiating local and far-end plaques with 808 nm laser to dissolve lipid. According to the invention, the nano magnetic material is used for fluorescence and magnetic resonance bimodal imaging diagnosis and near-infrared photothermal treatment of atherosclerosis; and the nano magnetic material and the preparation method thereof provided by the invention have a good application prospect, and the lipid is dissolved by using near-infrared heat treatment, so that the formation of the lipid is reversed, and the effect of treating atherosclerosis is good.

The invention discloses a simplified calculation method based on the formation and expansion of coronary multi-mode image cracks and an evaluation system for quantifying the risk of plaque rupture, which acquires coronary angiography images and intracavity images (such as optical coherence tomography) through an image input module Using image processing technology to segment and register interested blood vessels or plaques on different images, and quantitatively obtain the anatomical indexes of diseased coronary plaques, and further calculate superficial plaques based on time-series coronary angiography The distribution of wall dynamics indices and the determination of relatively high-risk locations along the longitudinal direction of the vessel to obtain the fatigue risk factor for localized crack formation in the superficial wall. The present invention combines the anatomical indicators of coronary multimodal images, and further increases the quantitative assessment of the risk of plaque crack expansion based on superficial coronary crack formation and cross-sectional images, so as to evaluate plaque more completely and comprehensively. rupture process.

The invention discloses combined application of atorvastatin calcium and atreleuton in preparation of drugs for treating and preventing coronary heart disease. The invention also provides a compound pharmaceutical composition for treating coronary heart disease. According to the invention, the inhibition effect on inflammation can be improved, hypersensitive C-reactive protein, plasma interleukinand the like can be reduced, the size of coronary plaques can be stabilized, even the effect of reversing plaques can be achieved, the compound pharmaceutical composition can effectively prevent and treat thrombosis and complications of atherosclerotic plaques by inhibiting inflammation, and has a very good protective effect on heart and blood vessels.

The present invention discloses systems and methods for predicting coronary artery plaque vulnerability using computer systems. A method comprising: acquiring anatomical image data of at least a portion of a patient's vasculature; performing one or more of image property analysis, geometric analysis, computational fluid dynamics analysis, and structural mechanics analysis on the anatomical image data using a processor; Using the processor to predict the presence of coronary plaque vulnerability in the patient's vasculature, wherein predicting the coronary plaque vulnerability includes based on image property analysis, geometric analysis of the anatomical image data calculating a malignant plaque property as a result of one or more of a computational fluid dynamics analysis and a structural mechanics analysis; and reporting the calculated malignant plaque property using the processor.

The invention provides a manufacturing method of a PVDF (Polyvinylidene Fluoride) micro-force sensor and an application method of the PVDF micro-force sensor in a surgical instrument, which are used for preparing a sensor capable of detecting stress data of a cardiovascular intervention surgical instrument in a blood vessel, and the micro-force sensor is of an elastic sandwich structure packaged by a waterproof and insulating protective film, comprises a piezoelectric film serving as a middle layer of the elastic sandwich structure, and further comprises two electrodes connected with the top face and the bottom face of the piezoelectric film respectively. The elastic sandwich structure is embedded in a mounting groove of the surgical instrument, the bottom surface or the top surface of the elastic sandwich structure is located on the outer surface of the surgical instrument, and when stress of the surgical instrument in a blood vessel is conducted to the micro-force sensor, a piezoelectric film of the micro-force sensor generates a detection electric signal; and according to the invention, the stress of a surgical instrument in a blood vessel can be measured with high sensitivity in real time, and the micro grinding force measuring device can be used for measuring the micro grinding force of collision between a rotary grinding head and a calcified tissue or a cardiovascular wall in a coronary artery plaque rotary grinding operation, so that the safety of removing the calcified tissue is improved.

The invention discloses a multi-frequency three-dimensional coronary artery plaque detecting method.The multi-frequency three-dimensional coronary artery plaque detecting method comprises the steps that S1, two current emitting electrodes and two voltage detecting electrodes are arranged on an impedance catheter, and a same-current multi-frequency scanning method is adopted to measure the cross section of the inner cavity of a blood vessel to be detected; S2, voltage values of the required measurement positions in the blood vessel to be detected where the impedance catheter is located are respectively acquired at the same current and in a sweep frequency state; S3, the impedance catheter is driven to perform uniform motion, and voltage values of the impedance catheter in the motion process are acquired at the same current in multiple frequency period switching states; S4, the voltage values obtained in the multiple frequency period switching states, the cross sections of the positions of the blood vessel to be detected and conductance parameters corresponding to plaque loads are acquired; S5, a numerical calculation and numerical optimization combination method is adopted to calculate three-dimensional spatial distribution of the plaque parameters of the positions of the blood vessel to be detected, and the three-dimensional spatial distribution of the plaques in the blood vessel wall is further determined.The multi-frequency three-dimensional coronary artery plaque detecting method is more accurate than a traditional single-frequency method.

The present invention discloses antibodies or fragments thereof able to bind isolated coronary plaque samples and processes for their production using host cells containing DNA sequences encoding for said antibodies of fragments thereof. Methods for screening ligands to said isolated samples are also described, and compositions containing said antibodies are also provided.